• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Dpt

General Information
Symbol	Dmel\Dpt	Species	D. melanogaster
Name	Diptericin	Annotation symbol	CG12763
Feature type	protein_coding_gene	FlyBase ID	FBgn0004240
Gene Model Status	Current	Stock availability	3 publicly available
Also Known As	dipt, DptA, Dip
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	55F8-55F8	Sequence location	2R:14,753,270..14,753,765 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Diptericin is referred to in FlyBase by the symbol Dmel\Dpt (CG12763, FBgn0004240). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: defense response to Gram-negative bacterium; antibacterial humoral response. 6 alleles are reported. The phenotypes of these alleles are annotated with: adult posterior midgut epithelium; mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: Attacin, C-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of extremely low expression. Peak expression observed during late larval stages, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1640022_at partially aligns to an exonic region of the only FlyBase-annotated transcript isoform of Dpt: 1 out of 14 probes fall into this exonic region. Gene sequence location is 2R:14753270..14753765.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	References Fellous and Lazzaro, 2011, Mol. Ecol. 20(7): 1558--1567
FB2012_01	References Clark et al., 2011, Curr. Biol. 21(19): 1672--1677 Abdelsadik and Roeder, 2010, BMC Genomics 11: 265 Thevenon et al., 2009, Cell Host Microbe 6(4): 309--320 Rao et al., 2011, Insect Biochem. Mol. Biol. 41(12): 982--992 Sequence features BKN27040 HFA07404
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 55F8-55F8   Limits computationally determined from genome sequence between P{PZ}l(2)0370903709 and P{lacW}prodk08810
Experimentally Determined Cytological Location
Cytogenetic map Notes References 56A-56A   (determined by in situ hybridisation)   (Reichhart et al., 1992) 56A-56A   (determined by in situ hybridisation)   (Wicker et al., 1990)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Dpt for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Dpt-RA FBtr0086620  NM_057460   496   106
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Dpt-PA   FBpp0085802   11.3   106   6.77     NP_476808   AAF57619
Additional Polypeptide Data & Comments
Reported size (kDa)	106 (aa); 9 (kD predicted) (Wicker et al., 1990) 106 (aa) (Reichhart et al., 1992)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Attacin, C-terminal (IPR005521)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF57619   AC004298   AC004322   AF019020 AAB82517   AF019021 AAB82518   AF019022 AAB82519   AF019023 AAB82520   AF019024 AAB82521   AF019025 AAB82522   AF019026 AAB82523   AF019027 AAB82524   AF019028 AAB82525   AF019029 AAB82526   AF019030 AAB82527   AF019031 AAB82528   AF019032 AAB82529   AF019033 AAB82530   AF019034 AAB82531   AI297596   AY071667 AAL49289   BI568337   BI570021   BI586299   BI593152   BI608573   BI610691   BI610915   BI618442   BI620377   BI627293   BI627878   BI629112   BI630908   BI630910   BI631858   CO153733   CO183613   M55432 AAA28466   Z11728 CAA77791
UniProtKB/Swiss-Prot	P24492
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References protein binding site FBsf0000159772 2R:14,753,210..14,753,241 evidence=experimental (Georgel et al., 1993, Bergman et al., 2004) protein binding site FBsf0000159773 2R:14,753,121..14,753,136 evidence=experimental (Bergman et al., 2004, Georgel et al., 1993) protein binding site FBsf0000159774 2R:14,753,079..14,753,093 evidence=experimental (Georgel et al., 1993, Bergman et al., 2004) protein binding site FBsf0000159775 2R:14,753,047..14,753,069 evidence=experimental (Georgel et al., 1993, Bergman et al., 2004) regulatory region FBsf0000161199 2R:14,753,047..14,753,058 comment=Protected region V. Protected in footprinting experiments with protein extracts from bacteria-challenged Drosophila. Contains HNF5 RE (hepatic nuclear factor 5 response element). evidence=experimental (Georgel et al., 1993) regulatory region FBsf0000161200 2R:14,753,059..14,753,069 comment=Protected region IV. Protected in footprinting experiments with protein extracts from bacteria-challenged Drosophila. Contains ICRE (interferon consensus response element). evidence=experimental (Georgel et al., 1993) regulatory region FBsf0000161201 2R:14,753,079..14,753,093 evidence=experimental comment=Protected region III. Protected in footprinting experiments with protein extracts from bacteria-challenged Drosophila. Contains IL6 RE (interleukin-6 response element). (Georgel et al., 1993) regulatory region FBsf0000161202 2R:14,753,117..14,753,133 comment=First of two 17 bp repeats necessary for the immune responsiveness of the Dpt gene evidence=experimental (Meister et al., 1994, Kappler et al., 1993) regulatory region FBsf0000161203 2R:14,753,121..14,753,136 comment=Protected region II. Protected in footprinting experiments with protein extracts from bacteria-challenged Drosophila. Contains kappaB-related RE. evidence=experimental (Georgel et al., 1993) regulatory region FBsf0000161195 2R:14,753,210..14,753,241 comment=Protected region I. Protected in footprinting experiments with protein extracts from bacteria-challenged Drosophila. Contains kappaB-related RE, ICRE, and IL6 RE. evidence=experimental (Georgel et al., 1993) regulatory region FBsf0000161204 2R:14,753,213..14,753,229 comment=Second of two 17 bp repeats necessary for the immune responsiveness of the Dpt gene evidence=experimental (Kappler et al., 1993, Meister et al., 1994)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
	Dpt transcripts are expressed in response to inoculation with a bacterial suspension. They are detected in adult males 2 hours after inoculation and reach a peak at 4 hours after inoculation. A similar response was observed in larvae and late pupae. A low level of Dpt transcripts was observed in untreated pupae and adults. (Wicker et al., 1990)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0004240    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0004240 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of extremely low expression. Peak expression observed during late larval stages, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0004240 expression level Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    15 embryo 04-06hr    10 embryo 06-08hr    14 embryo 08-10hr    12 embryo 10-12hr    4 embryo 12-14hr    5 embryo 14-16hr    9 embryo 16-18hr    20 embryo 18-20hr    98 embryo 20-22hr    19 embryo 22-24hr    43 larva L1    2 larva L2    5 larva L3 12hr old    254 larva L3 puffstage 1-2    7780 larva L3 puffstage 3-6    37334 larva L3 puffstage 7-9    22634 white prepupae new    16591 white prepupae 12hr    24715 white prepupae 24hr    19251 pupae 2d postWPP    11757 pupae 3d postWPP    4101 pupae 4d postWPP    1081 adult male 01day    2257 adult male 05day    1748 adult male 30day    5692 adult female 01day    12838 adult female 05day    4156 adult female 30day    17912 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    15 embryo 04-06hr    10 embryo 06-08hr    14 embryo 08-10hr    12 embryo 10-12hr    4 embryo 12-14hr    5 embryo 14-16hr    9 embryo 16-18hr    20 embryo 18-20hr    98 embryo 20-22hr    19 embryo 22-24hr    43 larva L1    2 larva L2    5 larva L3 12hr old  (254) larva L3 puffstage 1-2  (7780) larva L3 puffstage 3-6  (37334) larva L3 puffstage 7-9  (22634) white prepupae new  (16591) white prepupae 12hr  (24715) white prepupae 24hr  (19251) pupae 2d postWPP  (11757) pupae 3d postWPP  (4101) pupae 4d postWPP  (1081) adult male 01day  (2257) adult male 05day  (1748) adult male 30day  (5692) adult female 01day  (12838) adult female 05day  (4156) adult female 30day  (17912) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    15 embryo 04-06hr    10 embryo 06-08hr    14 embryo 08-10hr    12 embryo 10-12hr    4 embryo 12-14hr    5 embryo 14-16hr    9 embryo 16-18hr    20 embryo 18-20hr    98 embryo 20-22hr    19 embryo 22-24hr    43 larva L1    2 larva L2    5 larva L3 12hr old    254 larva L3 puffstage 1-2  (7780) larva L3 puffstage 3-6  (37334) larva L3 puffstage 7-9  (22634) white prepupae new  (16591) white prepupae 12hr  (24715) white prepupae 24hr  (19251) pupae 2d postWPP  (11757) pupae 3d postWPP  (4101) pupae 4d postWPP    1081 adult male 01day  (2257) adult male 05day  (1748) adult male 30day  (5692) adult female 01day  (12838) adult female 05day  (4156) adult female 30day  (17912) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    15 embryo 04-06hr    10 embryo 06-08hr    14 embryo 08-10hr    12 embryo 10-12hr    4 embryo 12-14hr    5 embryo 14-16hr    9 embryo 16-18hr    20 embryo 18-20hr    98 embryo 20-22hr    19 embryo 22-24hr    43 larva L1    2 larva L2    5 larva L3 12hr old    254 larva L3 puffstage 1-2    7780 larva L3 puffstage 3-6  (37334) larva L3 puffstage 7-9  (22634) white prepupae new  (16591) white prepupae 12hr  (24715) white prepupae 24hr  (19251) pupae 2d postWPP  (11757) pupae 3d postWPP    4101 pupae 4d postWPP    1081 adult male 01day    2257 adult male 05day    1748 adult male 30day    5692 adult female 01day  (12838) adult female 05day    4156 adult female 30day  (17912) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    15 embryo 04-06hr    10 embryo 06-08hr    14 embryo 08-10hr    12 embryo 10-12hr    4 embryo 12-14hr    5 embryo 14-16hr    9 embryo 16-18hr    20 embryo 18-20hr    98 embryo 20-22hr    19 embryo 22-24hr    43 larva L1    2 larva L2    5 larva L3 12hr old    254 larva L3 puffstage 1-2    7780 larva L3 puffstage 3-6    37334 larva L3 puffstage 7-9    22634 white prepupae new    16591 white prepupae 12hr    24715 white prepupae 24hr    19251 pupae 2d postWPP    11757 pupae 3d postWPP    4101 pupae 4d postWPP    1081 adult male 01day    2257 adult male 05day    1748 adult male 30day    5692 adult female 01day    12838 adult female 05day    4156 adult female 30day    17912 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0004240 expression level Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    15 embryo 04-06hr    10 embryo 06-08hr    14 embryo 08-10hr    12 embryo 10-12hr    4 embryo 12-14hr    5 embryo 14-16hr    9 embryo 16-18hr    20 embryo 18-20hr    98 embryo 20-22hr    19 embryo 22-24hr    43 larva L1    2 larva L2    5 larva L3 12hr old    254 larva L3 puffstage 1-2    7780 larva L3 puffstage 3-6    37334 larva L3 puffstage 7-9    22634 white prepupae new    16591 white prepupae 12hr    24715 white prepupae 24hr    19251 pupae 2d postWPP    11757 pupae 3d postWPP    4101 pupae 4d postWPP    1081 adult male 01day    2257 adult male 05day    1748 adult male 30day    5692 adult female 01day    12838 adult female 05day    4156 adult female 30day    17912 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    15 embryo 04-06hr    10 embryo 06-08hr    14 embryo 08-10hr    12 embryo 10-12hr    4 embryo 12-14hr    5 embryo 14-16hr    9 embryo 16-18hr    20 embryo 18-20hr    98 embryo 20-22hr    19 embryo 22-24hr    43 larva L1    2 larva L2    5 larva L3 12hr old  (254) larva L3 puffstage 1-2  (7780) larva L3 puffstage 3-6  (37334) larva L3 puffstage 7-9  (22634) white prepupae new  (16591) white prepupae 12hr  (24715) white prepupae 24hr  (19251) pupae 2d postWPP  (11757) pupae 3d postWPP  (4101) pupae 4d postWPP  (1081) adult male 01day  (2257) adult male 05day  (1748) adult male 30day  (5692) adult female 01day  (12838) adult female 05day  (4156) adult female 30day  (17912) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    15 embryo 04-06hr    10 embryo 06-08hr    14 embryo 08-10hr    12 embryo 10-12hr    4 embryo 12-14hr    5 embryo 14-16hr    9 embryo 16-18hr    20 embryo 18-20hr    98 embryo 20-22hr    19 embryo 22-24hr    43 larva L1    2 larva L2    5 larva L3 12hr old    254 larva L3 puffstage 1-2  (7780) larva L3 puffstage 3-6  (37334) larva L3 puffstage 7-9  (22634) white prepupae new  (16591) white prepupae 12hr  (24715) white prepupae 24hr  (19251) pupae 2d postWPP  (11757) pupae 3d postWPP  (4101) pupae 4d postWPP    1081 adult male 01day  2257 adult male 05day  1748 adult male 30day  (5692) adult female 01day  (12838) adult female 05day  (4156) adult female 30day  (17912) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    15 embryo 04-06hr    10 embryo 06-08hr    14 embryo 08-10hr    12 embryo 10-12hr    4 embryo 12-14hr    5 embryo 14-16hr    9 embryo 16-18hr    20 embryo 18-20hr    98 embryo 20-22hr    19 embryo 22-24hr    43 larva L1    2 larva L2    5 larva L3 12hr old    254 larva L3 puffstage 1-2    7780 larva L3 puffstage 3-6  (37334) larva L3 puffstage 7-9  (22634) white prepupae new  16591 white prepupae 12hr  (24715) white prepupae 24hr  19251 pupae 2d postWPP  11757 pupae 3d postWPP    4101 pupae 4d postWPP    1081 adult male 01day    2257 adult male 05day    1748 adult male 30day    5692 adult female 01day  12838 adult female 05day    4156 adult female 30day  17912 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    15 embryo 04-06hr    10 embryo 06-08hr    14 embryo 08-10hr    12 embryo 10-12hr    4 embryo 12-14hr    5 embryo 14-16hr    9 embryo 16-18hr    20 embryo 18-20hr    98 embryo 20-22hr    19 embryo 22-24hr    43 larva L1    2 larva L2    5 larva L3 12hr old    254 larva L3 puffstage 1-2    7780 larva L3 puffstage 3-6    37334 larva L3 puffstage 7-9    22634 white prepupae new    16591 white prepupae 12hr    24715 white prepupae 24hr    19251 pupae 2d postWPP    11757 pupae 3d postWPP    4101 pupae 4d postWPP    1081 adult male 01day    2257 adult male 05day    1748 adult male 30day    5692 adult female 01day    12838 adult female 05day    4156 adult female 30day    17912 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0004240    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0004240 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0004240 expression level Tissue   Expression Level Larval Central Nervous System    0.85 Larval Midgut    2.4 Larval Hindgut    3.2 Larval Malpighian Tubules    3.9 Larval Fat Body    6.6 Larval Salivary Gland    4.9 Larval Trachea    2.75 Larval Carcass    2.325 Adult Head    3.4 Adult Eye    3.15 Adult Brain    2.3 Adult Thoracic-Abdominal Ganglion    1.8 Adult Crop    2.2 Adult Midgut    7.3 Adult Hindgut    4.3 Adult Malpighian Tubules    2.5 Adult Fat Body    3.8 Adult Salivary Gland    6.8 Adult Heart    2.425 Adult VirginFemale Spermatheca    2.3 Adult InseminatedFemale Spermatheca    3.9 Adult Ovary    1.3 Adult Testis    2.6 Adult Male Accessory Gland    1.7 Adult Carcass    7.8 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    0.85 Larval Midgut    2.4 Larval Hindgut    3.2 Larval Malpighian Tubules    3.9 Larval Fat Body    6.6 Larval Salivary Gland    4.9 Larval Trachea    2.75 Larval Carcass    2.325 Adult Head    3.4 Adult Eye    3.15 Adult Brain    2.3 Adult Thoracic-Abdominal Ganglion    1.8 Adult Crop    2.2 Adult Midgut    7.3 Adult Hindgut    4.3 Adult Malpighian Tubules    2.5 Adult Fat Body    3.8 Adult Salivary Gland    6.8 Adult Heart    2.425 Adult VirginFemale Spermatheca    2.3 Adult InseminatedFemale Spermatheca    3.9 Adult Ovary    1.3 Adult Testis    2.6 Adult Male Accessory Gland    1.7 Adult Carcass    7.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    0.85 Larval Midgut    2.4 Larval Hindgut    3.2 Larval Malpighian Tubules    3.9 Larval Fat Body    6.6 Larval Salivary Gland    4.9 Larval Trachea    2.75 Larval Carcass    2.325 Adult Head    3.4 Adult Eye    3.15 Adult Brain    2.3 Adult Thoracic-Abdominal Ganglion    1.8 Adult Crop    2.2 Adult Midgut    7.3 Adult Hindgut    4.3 Adult Malpighian Tubules    2.5 Adult Fat Body    3.8 Adult Salivary Gland    6.8 Adult Heart    2.425 Adult VirginFemale Spermatheca    2.3 Adult InseminatedFemale Spermatheca    3.9 Adult Ovary    1.3 Adult Testis    2.6 Adult Male Accessory Gland    1.7 Adult Carcass    7.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    0.85 Larval Midgut    2.4 Larval Hindgut    3.2 Larval Malpighian Tubules    3.9 Larval Fat Body    6.6 Larval Salivary Gland    4.9 Larval Trachea    2.75 Larval Carcass    2.325 Adult Head    3.4 Adult Eye    3.15 Adult Brain    2.3 Adult Thoracic-Abdominal Ganglion    1.8 Adult Crop    2.2 Adult Midgut    7.3 Adult Hindgut    4.3 Adult Malpighian Tubules    2.5 Adult Fat Body    3.8 Adult Salivary Gland    6.8 Adult Heart    2.425 Adult VirginFemale Spermatheca    2.3 Adult InseminatedFemale Spermatheca    3.9 Adult Ovary    1.3 Adult Testis    2.6 Adult Male Accessory Gland    1.7 Adult Carcass    7.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0004240 expression level Tissue   Expression Level Larval Central Nervous System    0.85 Larval Midgut    2.4 Larval Hindgut    3.2 Larval Malpighian Tubules    3.9 Larval Fat Body    6.6 Larval Salivary Gland    4.9 Larval Trachea    2.75 Larval Carcass    2.325 Adult Head    3.4 Adult Eye    3.15 Adult Brain    2.3 Adult Thoracic-Abdominal Ganglion    1.8 Adult Crop    2.2 Adult Midgut    7.3 Adult Hindgut    4.3 Adult Malpighian Tubules    2.5 Adult Fat Body    3.8 Adult Salivary Gland    6.8 Adult Heart    2.425 Adult VirginFemale Spermatheca    2.3 Adult InseminatedFemale Spermatheca    3.9 Adult Ovary    1.3 Adult Testis    2.6 Adult Male Accessory Gland    1.7 Adult Carcass    7.8 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    0.85 Larval Midgut    2.4 Larval Hindgut    3.2 Larval Malpighian Tubules    3.9 Larval Fat Body    6.6 Larval Salivary Gland    4.9 Larval Trachea    2.75 Larval Carcass    2.325 Adult Head    3.4 Adult Eye    3.15 Adult Brain    2.3 Adult Thoracic-Abdominal Ganglion    1.8 Adult Crop    2.2 Adult Midgut    7.3 Adult Hindgut    4.3 Adult Malpighian Tubules    2.5 Adult Fat Body    3.8 Adult Salivary Gland    6.8 Adult Heart    2.425 Adult VirginFemale Spermatheca    2.3 Adult InseminatedFemale Spermatheca    3.9 Adult Ovary    1.3 Adult Testis    2.6 Adult Male Accessory Gland    1.7 Adult Carcass    7.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    0.85 Larval Midgut    2.4 Larval Hindgut    3.2 Larval Malpighian Tubules    3.9 Larval Fat Body    6.6 Larval Salivary Gland    4.9 Larval Trachea    2.75 Larval Carcass    2.325 Adult Head    3.4 Adult Eye    3.15 Adult Brain    2.3 Adult Thoracic-Abdominal Ganglion    1.8 Adult Crop    2.2 Adult Midgut    7.3 Adult Hindgut    4.3 Adult Malpighian Tubules    2.5 Adult Fat Body    3.8 Adult Salivary Gland    6.8 Adult Heart    2.425 Adult VirginFemale Spermatheca    2.3 Adult InseminatedFemale Spermatheca    3.9 Adult Ovary    1.3 Adult Testis    2.6 Adult Male Accessory Gland    1.7 Adult Carcass    7.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    0.85 Larval Midgut    2.4 Larval Hindgut    3.2 Larval Malpighian Tubules    3.9 Larval Fat Body    6.6 Larval Salivary Gland    4.9 Larval Trachea    2.75 Larval Carcass    2.325 Adult Head    3.4 Adult Eye    3.15 Adult Brain    2.3 Adult Thoracic-Abdominal Ganglion    1.8 Adult Crop    2.2 Adult Midgut    7.3 Adult Hindgut    4.3 Adult Malpighian Tubules    2.5 Adult Fat Body    3.8 Adult Salivary Gland    6.8 Adult Heart    2.425 Adult VirginFemale Spermatheca    2.3 Adult InseminatedFemale Spermatheca    3.9 Adult Ovary    1.3 Adult Testis    2.6 Adult Male Accessory Gland    1.7 Adult Carcass    7.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    3.4   NA  Eye    3.15   NA  Brain    2.3   0.85  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1.8   NA  Crop    2.2   2.4  Midgut    7.3   3.2  Hindgut    4.3   3.9  Malpighian Tubules    2.5   6.6  Fat Body    3.8   4.9  Salivary Gland    6.8   NA  Heart    2.425   2.75  Trachea    NA   NA  VirginFemale Spermatheca    2.3   NA  InseminatedFemale Spermatheca    3.9   NA  Ovary    1.3   NA  Testis    2.6   NA  Male Accessory Gland    1.7   2.325  Carcass    7.8 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004240 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12763-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage, with Scer\GAL4pnr-MD237 DptGD5831 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 DptGD5831 viable, with Scer\GAL4da.G32 DptScer\UAS.cTa Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 DptGD5831 Phenotype manifest in Allele adult posterior midgut epithelium, with Scer\GAL4da.G32 DptScer\UAS.cTa mesothoracic tergum, with Scer\GAL4pnr-MD237 DptGD5831
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Dpt Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Dpt Class Mutagen Stocks Known lesion DptGD5831 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes DptKK107040 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes DptORF1.1 in vitro construct 0 Yes DptORF in vitro construct - regulatory fusion 0 Yes DptScer\UAS.cTa in vitro construct - regulatory fusion 0 Yes DptScer\UAS.T:Disc\RFP-mCherry in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel6067 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5831} NA P{KK107040} NA P{UAS-Dpt.T} NA P{UAS-Dpt-cherry} NA reporter construct P{C208x17bp-lacZ} No P{Dipt0.6-lacZ} No P{Dipt2.2-lacZ} No P{Dipt2.2mut1-lacZ} No P{Dipt2.2mut2-lacZ} No P{Dipt2.2mut-lacZ} No P{Dipt3.7-lacZ} No P{Dipt10.5-lacZ} No P{Dpt-lacZ.201} No characterization construct P{Dipt2.2-ORF-1.1} NA P{Dipt2.2-ORF} NA P{Dpt-GFP.JM863} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
antibacterial humoral response inferred from expression pattern (Wicker et al., 1990, Lemaitre et al., 1997) defense response to Gram-negative bacterium inferred from expression pattern (Lemaitre et al., 1997)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
antibacterial humoral response non-traceable author statement (Swiss-Prot Project Members, 1992.3.1) defense response to bacterium inferred from sequence or structural similarity (Wicker et al., 1990) non-traceable author statement (Kimbrell and Beutler, 2001) traceable author statement (Meister et al., 2000) innate immune response non-traceable author statement (Kwiatkowski, 2005)
Cellular Component
CV term Evidence References
extracellular region inferred from electronic annotation with InterPro:IPR005521 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Dpt allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0004240 DroID - A comprehensive database of gene and protein interactions. • FBgn0004240 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37183
Orthologs
Genome-wide drosophilid orthologs	Dana\GF11124 Dere\GG21934 Dgri\GH22131 Dmoj\GI20150 Dper\GL11494 Dpse\GA24749 Dsec\GM21923 Dsim\GD11417 Dvir\GJ19915 Dwil\GK20931 Dyak\Dpt
Curated drosophilid orthologs	Dmau\Dpt   Dpse\GA11797   Dyak\Dpt
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0068166 FBgn0222923 FBgn0183166 FBgn0176800 FBgn0246135 FBgn0071846 FBgn0149103 FBgn0149102 FBgn0114112 FBgn0088164
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
VDRC	v104287 P{KK107040}VIE-260B v41284 w1118; P{GD5831}v41284 v41285 w1118; P{GD5831}v41285
Genomic Clones ( 1 )
	BACR27C21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 19 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RH02253
Other clones	DPiM_RH02253
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP11930 RH11091 RH13144 RH16275 RH16927 RH26196 RH39762 RH49261 RH51519 RH57926 RH60252 RH60254 RH61521 RH68559 RH69345
Other clones	EC26035 EN02703
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004240 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37183
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day. Shows alteration in expression in a Clk mutant background. (McDonald and Rosbash, 2001) In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes. (Kliman and Eyre-Walker, 1998) Ecol\lacZDpt.PR adults are pricked with a sterile needle dipped in culture pellets of various living microorganisms (distinct bacterial strains, fungal spores or hyphae). Pricking results in a low but clearly detectable expression of all antimicrobial genes and these genes are induced above the background level by specific classes of microorganism. (Lemaitre et al., 1997) Antibacterial genes are not induced in L.boulardi resistant strains of Drosophila suggesting they cannot be involved directly in the antiparasitoid response. (Coustau et al., 1996) The κB motifs of Dpt and CecA1 are not functionally equivalent. Mutants carrying no copies of dl and a single copy of Dif retain their full capacity to express the Dpt and CecA1 genes in response to bacterial challenge. (Gross et al., 1996) Genes encoding antibacterial peptides are regulated in a manner distinct from that of Drs, encoding the antifungal peptide. (Lemaitre et al., 1996) The response to Dipt::lacZ reporter constructs to bacterial challenge is ecdysteroid-dependent, being much reduced on a ecd1 or dor mutant background. (Meister and Richards, 1996) The increase, or maturation, of Dpt promoter activity during the third larval instar in response to bacterial challenge is ecdysteroid- dependent, as demonstrated using wild type and ecd1 or dor22 mutant larvae. (Meister and Richards, 1996) Transcription is not strongly induced by hymenopteran parasitoids. (Nicolas et al., 1996) A 45kD protein that binds sequence-specifically to the Dpt promoter GAAANN motif in fat body and blood cell extracts has been identified. (Georgel et al., 1995) Ecol\lacZ reporter gene constructs demonstrate that a 2.2kb upstream sequence can only confer full bacterial inducibility when it carries both 17bp motifs in the proximal promoter region. (Meister et al., 1994) Analysis of the Dpt promoter defined two 17bp repeats essential for LPS inducibility. Addition of extra copies of the 17bp repeat increases the level of transcription on LPS induction. A specific DNA-protein binding activity present only in induced blood cells and fat body suggests an induction mechanism similar to that of mammalian NF-κB. (Kappler et al., 1993) Dpt shows at least 4 distinct expression phases: young larvae, late third instar larvae, pupae and adults. The complexity may be related to the presence of multiple copies of response elements in the Dpt upstream sequences. (Reichhart et al., 1992) Isolated from a cDNA library using probes complementary to residues 38-43 of Phormia diptericin A. (Wicker et al., 1990)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057460 RefSeq (Proteins) • NP_476808 DDBJ / EMBL / GenBank • AAA28466 AAB82517 AAB82518 AAB82519 AAB82520 AAB82521 AAB82522 AAB82523 AAB82524 AAB82525 AAB82526 AAB82527 AAB82528 AAB82529 AAB82530 AAB82531 AAF57619 AAL49289 AC004298 AC004322 AF019020 AF019021 AF019022 AF019023 AF019024 AF019025 AF019026 AF019027 AF019028 AF019029 AF019030 AF019031 AF019032 AF019033 AF019034 AY071667 BI570021 CAA77791 M55432 Z11728 Entrez Gene - A searchable database of RefSeq genes. • 37183 UniProtKB/Swiss-Prot • P24492
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Attacin, C-terminal (IPR005521)
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0004240 DroID - A comprehensive database of gene and protein interactions. • FBgn0004240 DRSC - Results from RNAi screens. • FBgn0004240 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004240 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12763-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004240 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37183 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37183 modMine - Data generated by the modENCODE project. • FBgn0004240 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0068166 FBgn0222923 FBgn0183166 FBgn0176800 FBgn0246135 FBgn0071846 FBgn0149103 FBgn0149102 FBgn0114112 FBgn0088164 REDfly - A database of transcriptional regulatory elements. • FBgn0004240
Synonyms & Secondary IDs ( 18 )
Reported As
Symbol Synonym	143443_at (Kristensen et al., 2005) CG12763 (Irving et al., 2001, De Gregorio et al., 2001, Pal et al., 2007, Wang et al., 2006, Keleman et al., 2009.8.5, Hernandez-Romano et al., 2008, Douglas et al., 2011) Dep (Libert et al., 2006) Dip (Goto et al., 2003, Coustau et al., 1996, Goto et al., 2008) dip (Corbo and Levine, 1996) dipt (Guntermann et al., 2009, Munier et al., 2004, Georgel et al., 2001, Wu et al., 2001, Leulier et al., 2000, Williams et al., 1997, Flatt et al., 2006, Lee and Edery, 2008, Brown et al., 2009, Shia et al., 2009, Fan et al., 2010, Berkey et al., 2009, Igboin et al., 2011, Abdelsadik and Roeder, 2010) Dipt (Zambon et al., 2005, Apidianakis et al., 2005, Landis et al., 2004, Hay et al., 2004, Boulanger et al., 2001, Benassi et al., 2000, Clark, 1997.8.12, Clark, 1997.8.12, Clark, 1997.8.12, Clark, 1997.8.12, Clark, 1997.8.12, Clark, 1997.8.12, Clark, 1997.8.12, Clark, 1997.8.12, Clark, 1997.8.12, Clark, 1997.8.12, Clark, 1997.8.12, Clark, 1997.8.12, Clark, 1997.8.12, Clark, 1997.8.12, Clark, 1997.8.12, Hita et al., 1999, Braun et al., 1998, Nicolas et al., 1998, Lemaitre et al., 1997, Lemaitre et al., 1996, Meister et al., 1994, Jang et al., 2006, Leulier et al., 2006, Bergeret et al., 2008, Dijkers and O'Farrell, 2007, Vonkavaara et al., 2008, Paquette et al., 2010, Clark et al., 2011, Aymeric et al., 2010, Radyuk et al., 2010, Johansson et al., 2005, Thevenon et al., 2009) DIPT (Tzou et al., 2000, McGettigan et al., 2005) Dpt (Sackton and Clark, 2009, Scherfer et al., 2006, Kocks et al., 2005, Tang et al., 2006, Reiter et al., 2007, Brun et al., 2006, Domazet-Loso and Tautz, 2003, Harari-Steinberg et al., 2007, Ryu et al., 2008, Lhocine et al., 2008, Tang et al., 2008, Reed et al., 2008, Lee et al., 2005, Scherfer et al., 2008, Yajima et al., 2003, Wigby et al., 2008, Deddouche et al., 2008, Leulier et al., 2003, Charroux and Royet, 2009, Flatt et al., 2008, Linder et al., 2008, Ha et al., 2009, Buchon et al., 2009, Cronin et al., 2009, Greene et al., 2005, Aggarwal et al., 2008, Tauszig-Delamasure et al., 2002, Leulier et al., 2003, Kaneko et al., 2006, Becker et al., 2010, Wiklund et al., 2009, Buchon et al., 2010, Domanitskaya et al., 2007, Kikuchi et al., 2011, Zaidman-Rémy et al., 2011) DPT (Kwiatkowski, 2005) dpt (Ligoxygakis et al., 2002, McDonald and Rosbash, 2001, Lemaitre, 2000.12.20, Mulinari et al., 2006, Tsuda et al., 2005, Zsindely et al., 2009, Garbuzov and Tatar, 2010) DptA (Hedengren-Olcott et al., 2004, Hedengren et al., 2000, Lazzaro et al., 2004, Feng et al., 2009, Hill-Burns and Clark, 2009, Galac and Lazzaro, 2011, Sackton et al., 2010)
Name Synonym	Diptericin (Waterhouse et al., 2007, Reichhart, 1992.2.19, Pal et al., 2007, Zhou et al., 2005, Helenius et al., 2007, Mulinari et al., 2006, Kambris et al., 2006, Senger et al., 2006, Zraly et al., 2006, Rutschmann et al., 2000, Matova and Anderson, 2006, Chen et al., 2002, Harari-Steinberg et al., 2007, Sano et al., 2005, Taylor and Kimbrell, 2007, Goto et al., 2008, Leulier et al., 2006, Tanji et al., 2007, Ryu et al., 2008, Lhocine et al., 2008, Bergeret et al., 2008, Tang et al., 2008, Dijkers and O'Farrell, 2007, Reed et al., 2008, Wu et al., 2007, Wiklund et al., 2009, Yajima et al., 2003, Diangelo et al., 2009, Deddouche et al., 2008, Ligoxygakis et al., 2002, Leulier et al., 2003, Charroux and Royet, 2009, Ertürk-Hasdemir et al., 2009, Flatt et al., 2008, Luo et al., 2001, Kimbrell and Beutler, 2001, Buchon et al., 2009, Scherfer et al., 2008, Buchon et al., 2009, Carpenter et al., 2009, Fellous and Lazzaro, 2011, Aggarwal et al., 2008, Costa et al., 2009, Tauszig-Delamasure et al., 2002, Haghayeghi et al., 2010, Libert et al., 2006, Vonkavaara et al., 2008, Goto et al., 2010, Becker et al., 2010, Paquette et al., 2010, Zhao et al., 2010, Tanji et al., 2010, Lemos et al., 2010, Clark et al., 2011, Aymeric et al., 2010, Buchon et al., 2010, Wang et al., 2011, Akbar et al., 2011, Zaidman-Rémy et al., 2011, Schmidt et al., 2008, Johansson et al., 2005) diptericin (Okado et al., 2009, Guntermann et al., 2009, Delaney et al., 2005, Leclerc and Reichhart, 2004, Janssens and Beyaert, 2003, Ligoxtgakis, 2002, Mukae et al., 2002, Agaisse et al., 2003, Wicker et al., 1990, Ferrarese et al., 2007, Delaney et al., 2006, Cha et al., 2003, Kim et al., 2006, Avet-Rochex et al., 2005, Huh et al., 2007, Brennan et al., 2007, Silverman et al., 2008, Ratnaparkhi and Courey, 2008, Avet-Rochex et al., 2007, Hallem et al., 2007, Lee and Edery, 2008, Saleh et al., 2009, Brown et al., 2009, Tsuda et al., 2005, Johansson et al., 2006, Ren et al., 2007, Kapelnikov et al., 2008, Merkle et al., 2009, Stergiopoulos et al., 2009, Zerofsky et al., 2005, Shia et al., 2009, Leulier et al., 2003, Kaneko et al., 2006, Berkey et al., 2009, Garbuzov and Tatar, 2010, Radyuk et al., 2010, Domanitskaya et al., 2007, Igboin et al., 2011, Douglas et al., 2011) Diptericin A (Wang et al., 2006, Lazzaro et al., 2006, Lazzaro et al., 2004, Buchon et al., 2009, Galac and Lazzaro, 2011, Fellous and Lazzaro, 2010) diptericin A (Feng et al., 2009) DiptericinA (Hill-Burns and Clark, 2009) Diptericin precursor (Hernandez-Romano et al., 2008)
Secondary FlyBase IDs
References ( 312 )
Generate a list of	All references relating to this gene ( 312 )
List References by type	Research paper  ( 219 ) Supplementary material  ( 5 ) Review  ( 31 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 28 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 16 ) Letter  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 2 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 28 )
	Akbar et al., 2011, J. Cell Biol. 192(3): 383--390 The full-of-bacteria gene is required for phagosome maturation during immune defense in Drosophila. [FBrf0212933] Clark et al., 2011, Curr. Biol. 21(19): 1672--1677 Multiple TGF-β Superfamily Signals Modulate the Adult Drosophila Immune Response. [FBrf0216429] Douglas et al., 2011, Proc. Biol. Sci. 278(1704): 333--338 How the insect immune system interacts with an obligate symbiotic bacterium. [FBrf0212672] Fellous and Lazzaro, 2011, Mol. Ecol. 20(7): 1558--1567 Potential for evolutionary coupling and decoupling of larval and adult immune gene expression. [FBrf0214398] Galac and Lazzaro, 2011, Microbes Infect. 13(7): 673--683 Comparative pathology of bacteria in the genus Providencia to a natural host, Drosophila melanogaster. [FBrf0214338] Herren and Lemaitre, 2011, Cell. Microbiol. 13(9): 1385--1396 Spiroplasma and host immunity: activation of humoral immune responses increases endosymbiont load and susceptibility to certain Gram-negative bacterial pathogens in Drosophila melanogaster. [FBrf0214693] Igboin et al., 2011, Infect. Immun. 79(1): 449--458 Porphyromonas gingivalis-Host Interactions in a Drosophila melanogaster Model. [FBrf0212619] Kikuchi et al., 2011, Eur. J. Med. Chem. 46(4): 1263--1273 Synthesis and innate immunosuppressive effect of 1,2-cyclopentanediol derivatives. [FBrf0213182] Narbonne-Reveau et al., 2011, PLoS ONE 6(2): e17470 Lack of an antibacterial response defect in Drosophila toll-9 mutant. [FBrf0213211] Rao et al., 2011, Insect Biochem. Mol. Biol. 41(12): 982--992 Manduca sexta moricin promoter elements can increase promoter activities of Drosophila melanogaster antimicrobial peptide genes. [FBrf0216595] Wang et al., 2011, Infect. Immun. 79(2): 606--616 Host and Pathogen Glycosaminoglycan-Binding Proteins Modulate Antimicrobial Peptide Responses in Drosophila melanogaster. [FBrf0212806] Zaidman-Rémy et al., 2011, PLoS ONE 6(2): e17231 Drosophila Immunity: Analysis of PGRP-SB1 Expression, Enzymatic Activity and Function. [FBrf0213192] Abdelsadik and Roeder, 2010, BMC Genomics 11: 265 Chronic activation of the epithelial immune system of the fruit fly's salivary glands has a negative effect on organismal growth and induces a peculiar set of target genes. [FBrf0214863] Aymeric et al., 2010, Molec. Immunol. 47(14): 2342--2348 Imd pathway is involved in the interaction of Drosophila melanogaster with the entomopathogenic bacteria, Xenorhabdus nematophila and Photorhabdus luminescens. [FBrf0211463] Becker et al., 2010, Nature 463(7279): 369--373 FOXO-dependent regulation of innate immune homeostasis. [FBrf0209804] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Buchon et al., 2010, BMC Biol. 8: 152 Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection. [FBrf0212840] Fan et al., 2010, Genetics 184(1): 141--154 Drosophila translational elongation factor-1{gamma} is modified in response to DOA kinase activity and is essential for cellular viability. [FBrf0209673] Fellous and Lazzaro, 2010, Mol. Ecol. 19(7): 1462--1468 Larval food quality affects adult (but not larval) immune gene expression independent of effects on general condition. [FBrf0210732] Garbuzov and Tatar, 2010, Fly 4(4): 306--311 Hormonal regulation of Drosophila microRNA let-7 and miR-125 that target innate immunity. [FBrf0212526] Goto et al., 2010, J. Biol. Chem. 285(21): 15731--15738 Cooperative regulation of the induction of the novel antibacterial Listericin by peptidoglycan recognition protein LE and the JAK-STAT pathway. [FBrf0210770] Haghayeghi et al., 2010, Mech. Dev. 127(5-6): 301--307 Pellino enhances innate immunity in Drosophila. [FBrf0210800] Lemos et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(36): 15826--15831 Epigenetic effects of polymorphic Y chromosomes modulate chromatin components, immune response, and sexual conflict. [FBrf0211775] Paquette et al., 2010, Mol. Cell 37(2): 172--182 Caspase-Mediated Cleavage, IAP Binding, and Ubiquitination: Linking Three Mechanisms Crucial for Drosophila NF-kappaB Signaling. [FBrf0209837] Radyuk et al., 2010, Biochim. biophys. Acta 1800(11): 1153--1163 Peroxiredoxin 5 modulates immune response in Drosophila. [FBrf0211669] Sackton et al., 2010, PLoS Genet. 6(1): e1000797 Genotype and gene expression associations with immune function in Drosophila. [FBrf0209684] Tanji et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(33): 14715--14720 Heterodimers of NF-{kappa}B transcription factors DIF and Relish regulate antimicrobial peptide genes in Drosophila. [FBrf0211616] Zhao et al., 2010, PLoS ONE 5(7): e11701 Experimental selection for Drosophila survival in extremely high o(2) environments. [FBrf0211379] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...