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Gene Dmel\porin

General Information
Symbol	Dmel\porin	Species	D. melanogaster
Name	porin	Annotation symbol	CG6647
Feature type	protein_coding_gene	FlyBase ID	FBgn0004363
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	VDAC, l(2)k05123, DmVDAC
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	32B1-32B1	Sequence location	2L:10,847,227..10,850,848 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene porin is referred to in FlyBase by the symbol Dmel\porin (CG6647, FBgn0004363). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: voltage-gated anion channel activity. There is experimental evidence that it is involved in the biological process: phototransduction; sperm mitochondrion organization; sperm individualization; ion transport; mitochondrion organization. 36 alleles are reported. The phenotypes of these alleles are annotated with: photoreceptor; Nebenkern; embryonic/larval neuromuscular junction; testis; cystic bulge; waste bag; mitochondrion; seminal vesicle; indirect flight muscle. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: Eukaryotic porin/Tom40; Porin domain; Porin, eukaryotic type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1622947_s_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of porin. Gene sequence location is 2L:10847227..10850848.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 32B1-32B1   Limits computationally determined from genome sequence between P{PZ}dbf1 and P{lacW}SCARk03107
Experimentally Determined Cytological Location
Cytogenetic map Notes References 32B-32B     (Vito, 1997.7.29) 32B-32B     (Mesilaty-Gross, 1999.1.20) 32B1-32B2   (determined by in situ hybridisation)   (Spradling et al., 1999) 32B3-32B4   (determined by in situ hybridisation)   (Caggese et al., 1999) 32B3-32B4   (determined by in situ hybridisation)   (Oliva et al., 1998) 32B-32B   (determined by in situ hybridisation)   (Ryerse et al., 1997) 32B1-32B2   32B1--3   (BDGP Project Members, 1994-1999) 79D-79D   In situ hybridisation reveals a strong signal at 79D and a weaker signal at 31E. (determined by in situ hybridisation)   (Messina et al., 1996)   A cDNA clone also showed hybridization to 31E, but less strongly than at 79B. This may indicate the presence of two porin genes.   (De Pinto, 1995.10.16)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\porin for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45 Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) porin-RA FBtr0080182  NM_057465   1097   282 porin-RB FBtr0080183  NM_134283   1614   282 porin-RC FBtr0100584  NM_001038810   2625   282 porin-RD FBtr0305260  NM_001259032   1525   282 porin-RE FBtr0332029  NM_001273436   1387   282
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein porin-PA   FBpp0079771   30.5   282   6.97     NP_476813   AAF53022 porin-PB   FBpp0079772   30.5   282   6.97     NP_599110   AAN10766 porin-PC   FBpp0100039   30.5   282   6.97     NP_001033899   ABC65894 porin-PD   FBpp0293784   30.5   282   6.97     NP_001245961   AFH03635 porin-PE   FBpp0304343   30.5   282   6.97     NP_001260365   AGB92900
Additional Polypeptide Data & Comments
Reported size (kDa)	282 (aa) (Caggese et al., 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Porin, eukaryotic type (IPR001925) Eukaryotic porin/Tom40 (IPR027246) Porin domain (IPR023614) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME06647
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA246344   AA390359   AA390869   AA438418   AA438956   AA538775   AA540978   AA694786   AA695182   AA696478   AA696775   AA735594   AA735967   AA802324   AA802335   AA803575   AA803665   AA816531   AA820769   AA821145   AA950188   AA950352   AA950986   AA950990   AA951647   AE014134 AAF53022   AE014134 AAN10766   AE014134 ABC65894   AC007186   AE014134 AFH03635   AE014134 AGB92900   AI062309   AI063002   AI064301   AI107717   AI107923   AI107958   AI109404   AI109406   AI114339   AI134001   AI134337   AI134347   AI134383   AI134703   AI135007   AI257563   AI257970   AI259386   AI259965   AI260156   AI261034   AI292627   AI293031   AI294043   AI294215   AI294454   AI386538   AI386591   AI386671   AI386779   AI386935   AI388004   AI388303   AI404099   AI404900   AI405184   AI405677   AI405867   AI456550   AI513344   AI514474   AI514654   AI516549   AI516732   AI518978   AI519258   AI519865   AI519978   AI532249   AI534454   AI541763   AI543533   AI546258   AI946440   AJ000880 CAA04370   AQ034146   AW940403   AX664482   AY070509 AAL47980   AY232212   BE975931   BE976086   BE978457   BF487845   BF488816   BF496796   BF496834   BF500821   BF501625   BG632265   BG635437   BG635465   BG635877   BG636007   BG636595   BG637402   BG637489   BG640292   BG640335   BG640884   BG640948   BG641252   BG641456   BI162139   BI162334   BI162335   BI162348   BI162760   BI168026   BI168389   BI171241   BI171263   BI171374   BI172360   BI172594   BI173811   BI213342   BI213344   BI213573   BI215323   BI216175   BI227534   BI227585   BI228017   BI228407   BI230100   BI230185   BI230397   BI230927   BI232766   BI233080   BI233206   BI234525   BI236052   BI237191   BI238985   BI240038   BI241730   BI241750   BI242291   BI242466   BI242829   BI351960   BI352080   BI352120   BI352404   BI353181   BI353282   BI353454   BI353860   BI354865   BI355115   BI356074   BI357545   BI361323   BI362496   BI362530   BI364501   BI364524   BI364544   BI364744   BI365273   BI367181   BI367200   BI367658   BI370203   BI370427   BI371008   BI371451   BI373121   BI375087   BI482787   BI483133   BI483492   BI483972   BI486176   BI486708   BI486961   BI564255   BI565830   BI566058   BI566840   BI568202   BI568288   BI572341   BI573443   BI573444   BI574285   BI575628   BI578013   BI578689   BI580310   BI583569   BI584460   BI584727   BI584961   BI585933   BI588591   BI592931   BI606486   BI607240   BI609945   BI612090   BI613727   BI613928   BI615499   BI615687   BI616544   BI616856   BI617009   BI618818   BI620632   BI620713   BI621131   BI622677   BI623337   BI623834   BI624352   BI624582   BI624908   BI625144   BI625499   BI625701   BI625860   BI626810   BI626846   BI628492   BI628495   BI630259   BI630563   BI631539   BI631579   BI632426   BI632450   BI632894   BI633879   BI634153   BI634557   BI634776   BI634902   BI635054   BI635534   BI635883   BI635895   BI636064   BI637436   BI637560   BI638123   BI638601   BI639852   BI639956   BI640190   BP548124   BP548870   BP552224   BP556259   BP556260   BP557489   BP557490   BQ102782   BQ103594   BT024247   BX006602   BX013861   BX016779   BX017212   BX025834   BX045961   BX047517   BX048396   BX057282   BX059016   CK445221   CK605121   CK605122   CK605171   CK605172   CK658843   CK659824   CK660016   CK660495   CK660626   CK661944   CK661962   CO154174   CO177421   CO178176   CO181229   CO185045   CO187314   CO189193   CO191813   CO193779   CO196032   CO272523   CO274998   CO283916   CO285122   CO287171   CO287336   CO293980   CO295888   CO297489   CO314221   CO315376   CO316949   CO318035   CO322486   CO325597   CO331454   CO337586   CZ486190   CZ486191   DQ440237   EC068391   EC200570   EC201399   EC204283   EC205125   EC211713   EC216952   EC222816   EC226717   EC226898   EC231967   EC237335   EC241575   EC241581   EC247095   EC250039   EC260941   EC265216   EV576493   EV577748   EV579004   EV582428   EV585466   EV587331   EV588053   EV592886   EV593050   EV593206   EV594869   EV596119   EV597175   EV598929   EV599302   GH750339   GH754924   GH757107   GH757483   GH759254   GH772329   GH773041   GH773718   GH784822   GH786788   GH788484   GH791868   GH792556   GH795550   GH796012   GH800393   GH805303   GH805444   GH806323   GH806486   GH808698   GH809699   GH810919   GH814188   GH815296   GH816308   GH816553   GH817466   GH817794   GH823650   GH824602   GH826962   GH830184   GH830465   GH836109   GH836446   GH837148   GH840192   GH840714   GH841385   GH842071   GH849238   GH850036   GH851813   GH853410   GH856022   GH858385   GH858886   GH861573   GH863714   GH863937   GH864576   GH864892   GH867022   GH871893   GH872113   GH878851   GH880882   GH881355   GH883238   GH883481   GH884807   GH885124   GH888901   GH889979   GH890243   GH890545   GH895628   GH898480   GH902959   GH903033   GH903888   GH904734   GH906353   GH907899   GH908385   GH908421   GH909914   GH911422   GH911576   GH911648   GH911806   GH917232   GH917424   GH917431   GH918101   GH922493   GH929432   GH933940   GH934747   GH935106   GH937100   GH937954   GH939158   U70314 AAC02635   X92408 CAA63143   X95692
UniProtKB/Swiss-Prot	Q94920
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   antennal anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage central brain anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage dorsal head epidermis anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage visual anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage anterior endoderm anlage   (Fisher et al., 2012) dorsal ectoderm   (Fisher et al., 2012) foregut anlage   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) hindgut anlage   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   antennal primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium central brain primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium visual primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium anterior endoderm   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) inclusive hindgut primordium   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) central brain primordium   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) longitudinal visceral muscle primordium   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) somatic muscle primordium   (Fisher et al., 2012) Comment:reported as muscle system primordium visceral muscle primordium   (Fisher et al., 2012) Comment:reported as muscle system primordium trunk mesoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic foregut   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012) embryonic/larval visceral muscle   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012)
Additional Descriptive Data
	Three transcript sizes observed on Northern Blot. Sizes were not reported. (Oliva et al., 2002)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference adult stage | male   testis   (Oliva et al., 2002) spermatid   • Nebenkern (Oliva et al., 2002) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011) western blot Stage Tissue/Position (including subcellular localization) Reference pharate adult stage -- adult stage     (Oliva et al., 2002)
Additional Descriptive Data
	Expression of porin is exclusively concentrated in the Nebenkern bodies of spermatids. (Oliva et al., 2002)
Marker for
	Nebenkern
Subcellular Localization (GO Cellular Component)
CV term Evidence References
lipid particle inferred from direct assay (Beller et al., 2006, Cermelli et al., 2006) microtubule associated complex inferred from direct assay (Hughes et al., 2008) mitochondrion inferred from direct assay (Park et al., 2010, Alonso et al., 2005) Nebenkern inferred from direct assay (Oliva et al., 2002)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2252.375 Larval Midgut    1528.1 Larval Hindgut    3463.4 Larval Malpighian Tubules    2662.2 Larval Fat Body    945.2 Larval Salivary Gland    1534.2 Larval Trachea    1657.25 Larval Carcass    2248.65 Adult Head    2246.9 Adult Eye    2716.025 Adult Brain    2424.9 Adult Thoracic-Abdominal Ganglion    3065.9 Adult Crop    1893.6 Adult Midgut    2225.7 Adult Hindgut    3131.2 Adult Malpighian Tubules    2938 Adult Fat Body    2837 Adult Salivary Gland    1501.7 Adult Heart    2350.325 Adult VirginFemale Spermatheca    3179.1 Adult InseminatedFemale Spermatheca    3029 Adult Ovary    2039.1 Adult Testis    796.2 Adult Male Accessory Gland    1458.6 Adult Carcass    2626.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2252.375) Larval Midgut  (1528.1) Larval Hindgut  (3463.4) Larval Malpighian Tubules  (2662.2) Larval Fat Body  (945.2) Larval Salivary Gland  (1534.2) Larval Trachea  (1657.25) Larval Carcass  (2248.65) Adult Head  (2246.9) Adult Eye  (2716.025) Adult Brain  (2424.9) Adult Thoracic-Abdominal Ganglion  (3065.9) Adult Crop  (1893.6) Adult Midgut  (2225.7) Adult Hindgut  (3131.2) Adult Malpighian Tubules  (2938) Adult Fat Body  (2837) Adult Salivary Gland  (1501.7) Adult Heart  (2350.325) Adult VirginFemale Spermatheca  (3179.1) Adult InseminatedFemale Spermatheca  (3029) Adult Ovary  (2039.1) Adult Testis  (796.2) Adult Male Accessory Gland  (1458.6) Adult Carcass  (2626.2) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2252.375) Larval Midgut  (1528.1) Larval Hindgut  (3463.4) Larval Malpighian Tubules  (2662.2) Larval Fat Body    945.2 Larval Salivary Gland  (1534.2) Larval Trachea  (1657.25) Larval Carcass  (2248.65) Adult Head  (2246.9) Adult Eye  (2716.025) Adult Brain  (2424.9) Adult Thoracic-Abdominal Ganglion  (3065.9) Adult Crop  (1893.6) Adult Midgut  (2225.7) Adult Hindgut  (3131.2) Adult Malpighian Tubules  (2938) Adult Fat Body  (2837) Adult Salivary Gland  (1501.7) Adult Heart  (2350.325) Adult VirginFemale Spermatheca  (3179.1) Adult InseminatedFemale Spermatheca  (3029) Adult Ovary  (2039.1) Adult Testis    796.2 Adult Male Accessory Gland  (1458.6) Adult Carcass  (2626.2) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2252.375 Larval Midgut    1528.1 Larval Hindgut    3463.4 Larval Malpighian Tubules    2662.2 Larval Fat Body    945.2 Larval Salivary Gland    1534.2 Larval Trachea    1657.25 Larval Carcass    2248.65 Adult Head    2246.9 Adult Eye    2716.025 Adult Brain    2424.9 Adult Thoracic-Abdominal Ganglion    3065.9 Adult Crop    1893.6 Adult Midgut    2225.7 Adult Hindgut    3131.2 Adult Malpighian Tubules    2938 Adult Fat Body    2837 Adult Salivary Gland    1501.7 Adult Heart    2350.325 Adult VirginFemale Spermatheca    3179.1 Adult InseminatedFemale Spermatheca    3029 Adult Ovary    2039.1 Adult Testis    796.2 Adult Male Accessory Gland    1458.6 Adult Carcass    2626.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2252.375 Larval Midgut    1528.1 Larval Hindgut    3463.4 Larval Malpighian Tubules    2662.2 Larval Fat Body    945.2 Larval Salivary Gland    1534.2 Larval Trachea    1657.25 Larval Carcass    2248.65 Adult Head    2246.9 Adult Eye    2716.025 Adult Brain    2424.9 Adult Thoracic-Abdominal Ganglion    3065.9 Adult Crop    1893.6 Adult Midgut    2225.7 Adult Hindgut    3131.2 Adult Malpighian Tubules    2938 Adult Fat Body    2837 Adult Salivary Gland    1501.7 Adult Heart    2350.325 Adult VirginFemale Spermatheca    3179.1 Adult InseminatedFemale Spermatheca    3029 Adult Ovary    2039.1 Adult Testis    796.2 Adult Male Accessory Gland    1458.6 Adult Carcass    2626.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2252.375) Larval Midgut  (1528.1) Larval Hindgut  (3463.4) Larval Malpighian Tubules  (2662.2) Larval Fat Body  (945.2) Larval Salivary Gland  (1534.2) Larval Trachea  (1657.25) Larval Carcass  (2248.65) Adult Head  (2246.9) Adult Eye  (2716.025) Adult Brain  (2424.9) Adult Thoracic-Abdominal Ganglion  (3065.9) Adult Crop  (1893.6) Adult Midgut  (2225.7) Adult Hindgut  (3131.2) Adult Malpighian Tubules  (2938) Adult Fat Body  (2837) Adult Salivary Gland  (1501.7) Adult Heart  (2350.325) Adult VirginFemale Spermatheca  (3179.1) Adult InseminatedFemale Spermatheca  (3029) Adult Ovary  (2039.1) Adult Testis  796.2 Adult Male Accessory Gland  (1458.6) Adult Carcass  (2626.2) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2252.375) Larval Midgut  1528.1 Larval Hindgut  (3463.4) Larval Malpighian Tubules  (2662.2) Larval Fat Body    945.2 Larval Salivary Gland  1534.2 Larval Trachea  1657.25 Larval Carcass  (2248.65) Adult Head  (2246.9) Adult Eye  (2716.025) Adult Brain  (2424.9) Adult Thoracic-Abdominal Ganglion  (3065.9) Adult Crop  (1893.6) Adult Midgut  (2225.7) Adult Hindgut  (3131.2) Adult Malpighian Tubules  (2938) Adult Fat Body  (2837) Adult Salivary Gland  1501.7 Adult Heart  (2350.325) Adult VirginFemale Spermatheca  (3179.1) Adult InseminatedFemale Spermatheca  (3029) Adult Ovary  (2039.1) Adult Testis    796.2 Adult Male Accessory Gland  1458.6 Adult Carcass  (2626.2) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2252.375 Larval Midgut    1528.1 Larval Hindgut    3463.4 Larval Malpighian Tubules    2662.2 Larval Fat Body    945.2 Larval Salivary Gland    1534.2 Larval Trachea    1657.25 Larval Carcass    2248.65 Adult Head    2246.9 Adult Eye    2716.025 Adult Brain    2424.9 Adult Thoracic-Abdominal Ganglion    3065.9 Adult Crop    1893.6 Adult Midgut    2225.7 Adult Hindgut    3131.2 Adult Malpighian Tubules    2938 Adult Fat Body    2837 Adult Salivary Gland    1501.7 Adult Heart    2350.325 Adult VirginFemale Spermatheca    3179.1 Adult InseminatedFemale Spermatheca    3029 Adult Ovary    2039.1 Adult Testis    796.2 Adult Male Accessory Gland    1458.6 Adult Carcass    2626.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    2246.9   NA  Eye    2716.025   NA  Brain    2424.9   2252.375  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    3065.9   NA  Crop    1893.6   1528.1  Midgut    2225.7   3463.4  Hindgut    3131.2   2662.2  Malpighian Tubules    2938   945.2  Fat Body    2837   1534.2  Salivary Gland    1501.7   NA  Heart    2350.325   1657.25  Trachea    NA   NA  VirginFemale Spermatheca    3179.1   NA  InseminatedFemale Spermatheca    3029   NA  Ovary    2039.1   NA  Testis    796.2   NA  Male Accessory Gland    1458.6   2248.65  Carcass    2626.2 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    202 central nervous system, larvae L3    179 central nervous system, pupae P8    222 head, virgin 1-day female    318 head, virgin 4-day female    189 head, virgin 20-day female    156 head, mated 1-day female    241 head, mated 4-day female    144 head, mated 20-day female    129 head, mated 1-day male    368 head, mated 4-day male    208 head, mated 20-day male    253 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    41 digestive system, larvae L3 wandering    142 digestive system, 1-day adult    277 digestive system, 4-day adult    197 digestive system, 20-day adult    187 fat body, larvae L3 wandering    29 fat body, white prepupae    56 fat body, pupae P8    146 carcass, larvae L3 wandering    151 carcass, 1-day adult    341 carcass, 4-day adult    236 carcass, 20-day adult    182 ovary, virgin 4-day female    381 ovary, mated 4-day female    323 testis, mated 4-day male    185 accessory gland, mated 4-day male    108 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (202) central nervous system, larvae L3  (179) central nervous system, pupae P8  (222) head, virgin 1-day female  (318) head, virgin 4-day female  (189) head, virgin 20-day female  (156) head, mated 1-day female  (241) head, mated 4-day female  (144) head, mated 20-day female  (129) head, mated 1-day male  (368) head, mated 4-day male  (208) head, mated 20-day male  (253) salivary gland, larvae L3 wandering    13 salivary gland, white prepupae  (41) digestive system, larvae L3 wandering  (142) digestive system, 1-day adult  (277) digestive system, 4-day adult  (197) digestive system, 20-day adult  (187) fat body, larvae L3 wandering  (29) fat body, white prepupae  (56) fat body, pupae P8  (146) carcass, larvae L3 wandering  (151) carcass, 1-day adult  (341) carcass, 4-day adult  (236) carcass, 20-day adult  (182) ovary, virgin 4-day female  (381) ovary, mated 4-day female  (323) testis, mated 4-day male  (185) accessory gland, mated 4-day male  (108) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (202) central nervous system, larvae L3  (179) central nervous system, pupae P8  (222) head, virgin 1-day female  (318) head, virgin 4-day female  (189) head, virgin 20-day female  (156) head, mated 1-day female  (241) head, mated 4-day female  (144) head, mated 20-day female  (129) head, mated 1-day male  (368) head, mated 4-day male  (208) head, mated 20-day male  (253) salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    41 digestive system, larvae L3 wandering  (142) digestive system, 1-day adult  (277) digestive system, 4-day adult  (197) digestive system, 20-day adult  (187) fat body, larvae L3 wandering    29 fat body, white prepupae    56 fat body, pupae P8  (146) carcass, larvae L3 wandering  (151) carcass, 1-day adult  (341) carcass, 4-day adult  (236) carcass, 20-day adult  (182) ovary, virgin 4-day female  (381) ovary, mated 4-day female  (323) testis, mated 4-day male  (185) accessory gland, mated 4-day male  (108) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    202 central nervous system, larvae L3    179 central nervous system, pupae P8    222 head, virgin 1-day female    318 head, virgin 4-day female    189 head, virgin 20-day female    156 head, mated 1-day female    241 head, mated 4-day female    144 head, mated 20-day female    129 head, mated 1-day male    368 head, mated 4-day male    208 head, mated 20-day male    253 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    41 digestive system, larvae L3 wandering    142 digestive system, 1-day adult    277 digestive system, 4-day adult    197 digestive system, 20-day adult    187 fat body, larvae L3 wandering    29 fat body, white prepupae    56 fat body, pupae P8    146 carcass, larvae L3 wandering    151 carcass, 1-day adult    341 carcass, 4-day adult    236 carcass, 20-day adult    182 ovary, virgin 4-day female    381 ovary, mated 4-day female    323 testis, mated 4-day male    185 accessory gland, mated 4-day male    108 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    202 central nervous system, larvae L3    179 central nervous system, pupae P8    222 head, virgin 1-day female    318 head, virgin 4-day female    189 head, virgin 20-day female    156 head, mated 1-day female    241 head, mated 4-day female    144 head, mated 20-day female    129 head, mated 1-day male    368 head, mated 4-day male    208 head, mated 20-day male    253 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    41 digestive system, larvae L3 wandering    142 digestive system, 1-day adult    277 digestive system, 4-day adult    197 digestive system, 20-day adult    187 fat body, larvae L3 wandering    29 fat body, white prepupae    56 fat body, pupae P8    146 carcass, larvae L3 wandering    151 carcass, 1-day adult    341 carcass, 4-day adult    236 carcass, 20-day adult    182 ovary, virgin 4-day female    381 ovary, mated 4-day female    323 testis, mated 4-day male    185 accessory gland, mated 4-day male    108 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (202) central nervous system, larvae L3  (179) central nervous system, pupae P8  (222) head, virgin 1-day female  (318) head, virgin 4-day female  (189) head, virgin 20-day female  (156) head, mated 1-day female  (241) head, mated 4-day female  (144) head, mated 20-day female  (129) head, mated 1-day male  (368) head, mated 4-day male  (208) head, mated 20-day male  (253) salivary gland, larvae L3 wandering    13 salivary gland, white prepupae  (41) digestive system, larvae L3 wandering  (142) digestive system, 1-day adult  (277) digestive system, 4-day adult  (197) digestive system, 20-day adult  (187) fat body, larvae L3 wandering  29 fat body, white prepupae  (56) fat body, pupae P8  (146) carcass, larvae L3 wandering  (151) carcass, 1-day adult  (341) carcass, 4-day adult  (236) carcass, 20-day adult  (182) ovary, virgin 4-day female  (381) ovary, mated 4-day female  (323) testis, mated 4-day male  (185) accessory gland, mated 4-day male  (108) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (202) central nervous system, larvae L3  (179) central nervous system, pupae P8  (222) head, virgin 1-day female  (318) head, virgin 4-day female  (189) head, virgin 20-day female  (156) head, mated 1-day female  (241) head, mated 4-day female  (144) head, mated 20-day female  129 head, mated 1-day male  (368) head, mated 4-day male  (208) head, mated 20-day male  (253) salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    41 digestive system, larvae L3 wandering  142 digestive system, 1-day adult  (277) digestive system, 4-day adult  (197) digestive system, 20-day adult  (187) fat body, larvae L3 wandering    29 fat body, white prepupae    56 fat body, pupae P8  (146) carcass, larvae L3 wandering  (151) carcass, 1-day adult  (341) carcass, 4-day adult  (236) carcass, 20-day adult  (182) ovary, virgin 4-day female  (381) ovary, mated 4-day female  (323) testis, mated 4-day male  (185) accessory gland, mated 4-day male  108 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    202 central nervous system, larvae L3    179 central nervous system, pupae P8    222 head, virgin 1-day female    318 head, virgin 4-day female    189 head, virgin 20-day female    156 head, mated 1-day female    241 head, mated 4-day female    144 head, mated 20-day female    129 head, mated 1-day male    368 head, mated 4-day male    208 head, mated 20-day male    253 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    41 digestive system, larvae L3 wandering    142 digestive system, 1-day adult    277 digestive system, 4-day adult    197 digestive system, 20-day adult    187 fat body, larvae L3 wandering    29 fat body, white prepupae    56 fat body, pupae P8    146 carcass, larvae L3 wandering    151 carcass, 1-day adult    341 carcass, 4-day adult    236 carcass, 20-day adult    182 ovary, virgin 4-day female    381 ovary, mated 4-day female    323 testis, mated 4-day male    185 accessory gland, mated 4-day male    108 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    391 embryo 02-04hr    375 embryo 04-06hr    295 embryo 06-08hr    236 embryo 08-10hr    231 embryo 10-12hr    355 embryo 12-14hr    247 embryo 14-16hr    281 embryo 16-18hr    302 embryo 18-20hr    341 embryo 20-22hr    384 embryo 22-24hr    371 larva L1    628 larva L2    704 larva L3 12hr old    591 larva L3 puffstage 1-2    211 larva L3 puffstage 3-6    150 larva L3 puffstage 7-9    159 white prepupae new    185 white prepupae 12hr    140 white prepupae 24hr    159 pupae 2d postWPP    479 pupae 3d postWPP    601 pupae 4d postWPP    366 adult male 01day    385 adult male 05day    360 adult male 30day    239 adult female 01day    417 adult female 05day    376 adult female 30day    333 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (391) embryo 02-04hr  (375) embryo 04-06hr  (295) embryo 06-08hr  (236) embryo 08-10hr  (231) embryo 10-12hr  (355) embryo 12-14hr  (247) embryo 14-16hr  (281) embryo 16-18hr  (302) embryo 18-20hr  (341) embryo 20-22hr  (384) embryo 22-24hr  (371) larva L1  (628) larva L2  (704) larva L3 12hr old  (591) larva L3 puffstage 1-2  (211) larva L3 puffstage 3-6  (150) larva L3 puffstage 7-9  (159) white prepupae new  (185) white prepupae 12hr  (140) white prepupae 24hr  (159) pupae 2d postWPP  (479) pupae 3d postWPP  (601) pupae 4d postWPP  (366) adult male 01day  (385) adult male 05day  (360) adult male 30day  (239) adult female 01day  (417) adult female 05day  (376) adult female 30day  (333) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (391) embryo 02-04hr  (375) embryo 04-06hr  (295) embryo 06-08hr  (236) embryo 08-10hr  (231) embryo 10-12hr  (355) embryo 12-14hr  (247) embryo 14-16hr  (281) embryo 16-18hr  (302) embryo 18-20hr  (341) embryo 20-22hr  (384) embryo 22-24hr  (371) larva L1  (628) larva L2  (704) larva L3 12hr old  (591) larva L3 puffstage 1-2  (211) larva L3 puffstage 3-6  (150) larva L3 puffstage 7-9  (159) white prepupae new  (185) white prepupae 12hr  (140) white prepupae 24hr  (159) pupae 2d postWPP  (479) pupae 3d postWPP  (601) pupae 4d postWPP  (366) adult male 01day  (385) adult male 05day  (360) adult male 30day  (239) adult female 01day  (417) adult female 05day  (376) adult female 30day  (333) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    391 embryo 02-04hr    375 embryo 04-06hr    295 embryo 06-08hr    236 embryo 08-10hr    231 embryo 10-12hr    355 embryo 12-14hr    247 embryo 14-16hr    281 embryo 16-18hr    302 embryo 18-20hr    341 embryo 20-22hr    384 embryo 22-24hr    371 larva L1    628 larva L2    704 larva L3 12hr old    591 larva L3 puffstage 1-2    211 larva L3 puffstage 3-6    150 larva L3 puffstage 7-9    159 white prepupae new    185 white prepupae 12hr    140 white prepupae 24hr    159 pupae 2d postWPP    479 pupae 3d postWPP    601 pupae 4d postWPP    366 adult male 01day    385 adult male 05day    360 adult male 30day    239 adult female 01day    417 adult female 05day    376 adult female 30day    333 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    391 embryo 02-04hr    375 embryo 04-06hr    295 embryo 06-08hr    236 embryo 08-10hr    231 embryo 10-12hr    355 embryo 12-14hr    247 embryo 14-16hr    281 embryo 16-18hr    302 embryo 18-20hr    341 embryo 20-22hr    384 embryo 22-24hr    371 larva L1    628 larva L2    704 larva L3 12hr old    591 larva L3 puffstage 1-2    211 larva L3 puffstage 3-6    150 larva L3 puffstage 7-9    159 white prepupae new    185 white prepupae 12hr    140 white prepupae 24hr    159 pupae 2d postWPP    479 pupae 3d postWPP    601 pupae 4d postWPP    366 adult male 01day    385 adult male 05day    360 adult male 30day    239 adult female 01day    417 adult female 05day    376 adult female 30day    333 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (391) embryo 02-04hr  (375) embryo 04-06hr  (295) embryo 06-08hr  (236) embryo 08-10hr  (231) embryo 10-12hr  (355) embryo 12-14hr  (247) embryo 14-16hr  (281) embryo 16-18hr  (302) embryo 18-20hr  (341) embryo 20-22hr  (384) embryo 22-24hr  (371) larva L1  (628) larva L2  (704) larva L3 12hr old  (591) larva L3 puffstage 1-2  (211) larva L3 puffstage 3-6  (150) larva L3 puffstage 7-9  (159) white prepupae new  (185) white prepupae 12hr  (140) white prepupae 24hr  (159) pupae 2d postWPP  (479) pupae 3d postWPP  (601) pupae 4d postWPP  (366) adult male 01day  (385) adult male 05day  (360) adult male 30day  (239) adult female 01day  (417) adult female 05day  (376) adult female 30day  (333) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (391) embryo 02-04hr  (375) embryo 04-06hr  (295) embryo 06-08hr  (236) embryo 08-10hr  (231) embryo 10-12hr  (355) embryo 12-14hr  (247) embryo 14-16hr  (281) embryo 16-18hr  (302) embryo 18-20hr  (341) embryo 20-22hr  (384) embryo 22-24hr  (371) larva L1  (628) larva L2  (704) larva L3 12hr old  (591) larva L3 puffstage 1-2  (211) larva L3 puffstage 3-6  (150) larva L3 puffstage 7-9  (159) white prepupae new  (185) white prepupae 12hr  140 white prepupae 24hr  (159) pupae 2d postWPP  (479) pupae 3d postWPP  (601) pupae 4d postWPP  (366) adult male 01day  (385) adult male 05day  (360) adult male 30day  (239) adult female 01day  (417) adult female 05day  (376) adult female 30day  (333) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    391 embryo 02-04hr    375 embryo 04-06hr    295 embryo 06-08hr    236 embryo 08-10hr    231 embryo 10-12hr    355 embryo 12-14hr    247 embryo 14-16hr    281 embryo 16-18hr    302 embryo 18-20hr    341 embryo 20-22hr    384 embryo 22-24hr    371 larva L1    628 larva L2    704 larva L3 12hr old    591 larva L3 puffstage 1-2    211 larva L3 puffstage 3-6    150 larva L3 puffstage 7-9    159 white prepupae new    185 white prepupae 12hr    140 white prepupae 24hr    159 pupae 2d postWPP    479 pupae 3d postWPP    601 pupae 4d postWPP    366 adult male 01day    385 adult male 05day    360 adult male 30day    239 adult female 01day    417 adult female 05day    376 adult female 30day    333 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    404 Schneider line 2 Sg4    434 embryonic 1182-4H    224 embryonic GM2    173 embryonic Kc167    170 embryonic S1    348 embryonic S3    302 leg disc CME L1    358 wing disc CME-W2    306 wing disc ML-DmD8    228 wing disc ML-DmD9    308 wing disc ML-DmD16-c3    205 wing disc ML-DmD21    863 wing disc ML-DmD32    223 haltere disc ML-DmD17-c3    277 eye-antennal disc ML-DmD11    418 antennal disc ML-DmD20-c5    308 mixed discs ML-DmD4-c1    323 CNS ML-DmBG1-c1    240 CNS ML-DmBG2-c2    328 tumorous blood cells mbn2    175 ovary fGS/OSS    144 ovary OSC    166 ovary OSS    105 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (404) Schneider line 2 Sg4  (434) embryonic 1182-4H  (224) embryonic GM2  (173) embryonic Kc167  (170) embryonic S1  (348) embryonic S3  (302) leg disc CME L1  (358) wing disc CME-W2  (306) wing disc ML-DmD8  (228) wing disc ML-DmD9  (308) wing disc ML-DmD16-c3  (205) wing disc ML-DmD21  (863) wing disc ML-DmD32  (223) haltere disc ML-DmD17-c3  (277) eye-antennal disc ML-DmD11  (418) antennal disc ML-DmD20-c5  (308) mixed discs ML-DmD4-c1  (323) CNS ML-DmBG1-c1  (240) CNS ML-DmBG2-c2  (328) tumorous blood cells mbn2  (175) ovary fGS/OSS  (144) ovary OSC  (166) ovary OSS  (105) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (404) Schneider line 2 Sg4  (434) embryonic 1182-4H  (224) embryonic GM2  (173) embryonic Kc167  (170) embryonic S1  (348) embryonic S3  (302) leg disc CME L1  (358) wing disc CME-W2  (306) wing disc ML-DmD8  (228) wing disc ML-DmD9  (308) wing disc ML-DmD16-c3  (205) wing disc ML-DmD21  (863) wing disc ML-DmD32  (223) haltere disc ML-DmD17-c3  (277) eye-antennal disc ML-DmD11  (418) antennal disc ML-DmD20-c5  (308) mixed discs ML-DmD4-c1  (323) CNS ML-DmBG1-c1  (240) CNS ML-DmBG2-c2  (328) tumorous blood cells mbn2  (175) ovary fGS/OSS  (144) ovary OSC  (166) ovary OSS  105 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    404 Schneider line 2 Sg4    434 embryonic 1182-4H    224 embryonic GM2    173 embryonic Kc167    170 embryonic S1    348 embryonic S3    302 leg disc CME L1    358 wing disc CME-W2    306 wing disc ML-DmD8    228 wing disc ML-DmD9    308 wing disc ML-DmD16-c3    205 wing disc ML-DmD21    863 wing disc ML-DmD32    223 haltere disc ML-DmD17-c3    277 eye-antennal disc ML-DmD11    418 antennal disc ML-DmD20-c5    308 mixed discs ML-DmD4-c1    323 CNS ML-DmBG1-c1    240 CNS ML-DmBG2-c2    328 tumorous blood cells mbn2    175 ovary fGS/OSS    144 ovary OSC    166 ovary OSS    105 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    404 Schneider line 2 Sg4    434 embryonic 1182-4H    224 embryonic GM2    173 embryonic Kc167    170 embryonic S1    348 embryonic S3    302 leg disc CME L1    358 wing disc CME-W2    306 wing disc ML-DmD8    228 wing disc ML-DmD9    308 wing disc ML-DmD16-c3    205 wing disc ML-DmD21    863 wing disc ML-DmD32    223 haltere disc ML-DmD17-c3    277 eye-antennal disc ML-DmD11    418 antennal disc ML-DmD20-c5    308 mixed discs ML-DmD4-c1    323 CNS ML-DmBG1-c1    240 CNS ML-DmBG2-c2    328 tumorous blood cells mbn2    175 ovary fGS/OSS    144 ovary OSC    166 ovary OSS    105 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (404) Schneider line 2 Sg4  (434) embryonic 1182-4H  (224) embryonic GM2  (173) embryonic Kc167  (170) embryonic S1  (348) embryonic S3  (302) leg disc CME L1  (358) wing disc CME-W2  (306) wing disc ML-DmD8  (228) wing disc ML-DmD9  (308) wing disc ML-DmD16-c3  (205) wing disc ML-DmD21  (863) wing disc ML-DmD32  (223) haltere disc ML-DmD17-c3  (277) eye-antennal disc ML-DmD11  (418) antennal disc ML-DmD20-c5  (308) mixed discs ML-DmD4-c1  (323) CNS ML-DmBG1-c1  (240) CNS ML-DmBG2-c2  (328) tumorous blood cells mbn2  (175) ovary fGS/OSS  (144) ovary OSC  (166) ovary OSS  (105) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (404) Schneider line 2 Sg4  (434) embryonic 1182-4H  (224) embryonic GM2  (173) embryonic Kc167  (170) embryonic S1  (348) embryonic S3  (302) leg disc CME L1  (358) wing disc CME-W2  (306) wing disc ML-DmD8  (228) wing disc ML-DmD9  (308) wing disc ML-DmD16-c3  (205) wing disc ML-DmD21  (863) wing disc ML-DmD32  (223) haltere disc ML-DmD17-c3  (277) eye-antennal disc ML-DmD11  (418) antennal disc ML-DmD20-c5  (308) mixed discs ML-DmD4-c1  (323) CNS ML-DmBG1-c1  (240) CNS ML-DmBG2-c2  (328) tumorous blood cells mbn2  (175) ovary fGS/OSS  (144) ovary OSC  (166) ovary OSS  105 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    404 Schneider line 2 Sg4    434 embryonic 1182-4H    224 embryonic GM2    173 embryonic Kc167    170 embryonic S1    348 embryonic S3    302 leg disc CME L1    358 wing disc CME-W2    306 wing disc ML-DmD8    228 wing disc ML-DmD9    308 wing disc ML-DmD16-c3    205 wing disc ML-DmD21    863 wing disc ML-DmD32    223 haltere disc ML-DmD17-c3    277 eye-antennal disc ML-DmD11    418 antennal disc ML-DmD20-c5    308 mixed discs ML-DmD4-c1    323 CNS ML-DmBG1-c1    240 CNS ML-DmBG2-c2    328 tumorous blood cells mbn2    175 ovary fGS/OSS    144 ovary OSC    166 ovary OSS    105 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    139 cold shock, 4-day adult    118 heat shock, 4-day adult    347 Cadmium 50 mM 6 hrs, larvae L3    437 Cadmium 50 mM 12 hrs, larvae L3    250 Cadmium 50 mM 48 hrs, 4-day adult    340 Cadmium 100 mM 48 hrs, 4-day adult    257 Copper 0.5 mM 12 hrs, larvae L3    205 Copper 15 mM 48 hrs, 4-day adult    157 Zinc 5 mM 12 hrs, larvae L3    187 Zinc 4.5 mM 48 hrs, 4-day adult    175 Ethanol 2.5% 3 hrs, larvae L3    370 Ethanol 5% 3 hrs, larvae L3    422 Ethanol 10% 3 hrs, larvae L3    414 Caffeine 1.5 mg/ml 4 hrs, larvae L3    295 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    259 Caffeine 25 mg/ml 48 hrs, 4-day adult    132 Paraquat 5 mM 48 hrs, 4-day adult    315 Paraquat 10 mM 48 hrs, 4-day adult    323 Rotenone 2 μg 12 hrs, larvae L3    395 Rotenone 8 μg 12 hrs, larvae L3    546 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (139) cold shock, 4-day adult  (118) heat shock, 4-day adult  (347) Cadmium 50 mM 6 hrs, larvae L3  (437) Cadmium 50 mM 12 hrs, larvae L3  (250) Cadmium 50 mM 48 hrs, 4-day adult  (340) Cadmium 100 mM 48 hrs, 4-day adult  (257) Copper 0.5 mM 12 hrs, larvae L3  (205) Copper 15 mM 48 hrs, 4-day adult  (157) Zinc 5 mM 12 hrs, larvae L3  (187) Zinc 4.5 mM 48 hrs, 4-day adult  (175) Ethanol 2.5% 3 hrs, larvae L3  (370) Ethanol 5% 3 hrs, larvae L3  (422) Ethanol 10% 3 hrs, larvae L3  (414) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (295) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (259) Caffeine 25 mg/ml 48 hrs, 4-day adult  (132) Paraquat 5 mM 48 hrs, 4-day adult  (315) Paraquat 10 mM 48 hrs, 4-day adult  (323) Rotenone 2 μg 12 hrs, larvae L3  (395) Rotenone 8 μg 12 hrs, larvae L3  (546) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (139) cold shock, 4-day adult  (118) heat shock, 4-day adult  (347) Cadmium 50 mM 6 hrs, larvae L3  (437) Cadmium 50 mM 12 hrs, larvae L3  (250) Cadmium 50 mM 48 hrs, 4-day adult  (340) Cadmium 100 mM 48 hrs, 4-day adult  (257) Copper 0.5 mM 12 hrs, larvae L3  (205) Copper 15 mM 48 hrs, 4-day adult  (157) Zinc 5 mM 12 hrs, larvae L3  (187) Zinc 4.5 mM 48 hrs, 4-day adult  (175) Ethanol 2.5% 3 hrs, larvae L3  (370) Ethanol 5% 3 hrs, larvae L3  (422) Ethanol 10% 3 hrs, larvae L3  (414) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (295) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (259) Caffeine 25 mg/ml 48 hrs, 4-day adult  (132) Paraquat 5 mM 48 hrs, 4-day adult  (315) Paraquat 10 mM 48 hrs, 4-day adult  (323) Rotenone 2 μg 12 hrs, larvae L3  (395) Rotenone 8 μg 12 hrs, larvae L3  (546) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    139 cold shock, 4-day adult    118 heat shock, 4-day adult    347 Cadmium 50 mM 6 hrs, larvae L3    437 Cadmium 50 mM 12 hrs, larvae L3    250 Cadmium 50 mM 48 hrs, 4-day adult    340 Cadmium 100 mM 48 hrs, 4-day adult    257 Copper 0.5 mM 12 hrs, larvae L3    205 Copper 15 mM 48 hrs, 4-day adult    157 Zinc 5 mM 12 hrs, larvae L3    187 Zinc 4.5 mM 48 hrs, 4-day adult    175 Ethanol 2.5% 3 hrs, larvae L3    370 Ethanol 5% 3 hrs, larvae L3    422 Ethanol 10% 3 hrs, larvae L3    414 Caffeine 1.5 mg/ml 4 hrs, larvae L3    295 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    259 Caffeine 25 mg/ml 48 hrs, 4-day adult    132 Paraquat 5 mM 48 hrs, 4-day adult    315 Paraquat 10 mM 48 hrs, 4-day adult    323 Rotenone 2 μg 12 hrs, larvae L3    395 Rotenone 8 μg 12 hrs, larvae L3    546 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    139 cold shock, 4-day adult    118 heat shock, 4-day adult    347 Cadmium 50 mM 6 hrs, larvae L3    437 Cadmium 50 mM 12 hrs, larvae L3    250 Cadmium 50 mM 48 hrs, 4-day adult    340 Cadmium 100 mM 48 hrs, 4-day adult    257 Copper 0.5 mM 12 hrs, larvae L3    205 Copper 15 mM 48 hrs, 4-day adult    157 Zinc 5 mM 12 hrs, larvae L3    187 Zinc 4.5 mM 48 hrs, 4-day adult    175 Ethanol 2.5% 3 hrs, larvae L3    370 Ethanol 5% 3 hrs, larvae L3    422 Ethanol 10% 3 hrs, larvae L3    414 Caffeine 1.5 mg/ml 4 hrs, larvae L3    295 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    259 Caffeine 25 mg/ml 48 hrs, 4-day adult    132 Paraquat 5 mM 48 hrs, 4-day adult    315 Paraquat 10 mM 48 hrs, 4-day adult    323 Rotenone 2 μg 12 hrs, larvae L3    395 Rotenone 8 μg 12 hrs, larvae L3    546 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (139) cold shock, 4-day adult  (118) heat shock, 4-day adult  (347) Cadmium 50 mM 6 hrs, larvae L3  (437) Cadmium 50 mM 12 hrs, larvae L3  (250) Cadmium 50 mM 48 hrs, 4-day adult  (340) Cadmium 100 mM 48 hrs, 4-day adult  (257) Copper 0.5 mM 12 hrs, larvae L3  (205) Copper 15 mM 48 hrs, 4-day adult  (157) Zinc 5 mM 12 hrs, larvae L3  (187) Zinc 4.5 mM 48 hrs, 4-day adult  (175) Ethanol 2.5% 3 hrs, larvae L3  (370) Ethanol 5% 3 hrs, larvae L3  (422) Ethanol 10% 3 hrs, larvae L3  (414) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (295) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (259) Caffeine 25 mg/ml 48 hrs, 4-day adult  (132) Paraquat 5 mM 48 hrs, 4-day adult  (315) Paraquat 10 mM 48 hrs, 4-day adult  (323) Rotenone 2 μg 12 hrs, larvae L3  (395) Rotenone 8 μg 12 hrs, larvae L3  (546) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  139 cold shock, 4-day adult  118 heat shock, 4-day adult  (347) Cadmium 50 mM 6 hrs, larvae L3  (437) Cadmium 50 mM 12 hrs, larvae L3  (250) Cadmium 50 mM 48 hrs, 4-day adult  (340) Cadmium 100 mM 48 hrs, 4-day adult  (257) Copper 0.5 mM 12 hrs, larvae L3  (205) Copper 15 mM 48 hrs, 4-day adult  (157) Zinc 5 mM 12 hrs, larvae L3  (187) Zinc 4.5 mM 48 hrs, 4-day adult  (175) Ethanol 2.5% 3 hrs, larvae L3  (370) Ethanol 5% 3 hrs, larvae L3  (422) Ethanol 10% 3 hrs, larvae L3  (414) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (295) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (259) Caffeine 25 mg/ml 48 hrs, 4-day adult  132 Paraquat 5 mM 48 hrs, 4-day adult  (315) Paraquat 10 mM 48 hrs, 4-day adult  (323) Rotenone 2 μg 12 hrs, larvae L3  (395) Rotenone 8 μg 12 hrs, larvae L3  (546) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    139 cold shock, 4-day adult    118 heat shock, 4-day adult    347 Cadmium 50 mM 6 hrs, larvae L3    437 Cadmium 50 mM 12 hrs, larvae L3    250 Cadmium 50 mM 48 hrs, 4-day adult    340 Cadmium 100 mM 48 hrs, 4-day adult    257 Copper 0.5 mM 12 hrs, larvae L3    205 Copper 15 mM 48 hrs, 4-day adult    157 Zinc 5 mM 12 hrs, larvae L3    187 Zinc 4.5 mM 48 hrs, 4-day adult    175 Ethanol 2.5% 3 hrs, larvae L3    370 Ethanol 5% 3 hrs, larvae L3    422 Ethanol 10% 3 hrs, larvae L3    414 Caffeine 1.5 mg/ml 4 hrs, larvae L3    295 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    259 Caffeine 25 mg/ml 48 hrs, 4-day adult    132 Paraquat 5 mM 48 hrs, 4-day adult    315 Paraquat 10 mM 48 hrs, 4-day adult    323 Rotenone 2 μg 12 hrs, larvae L3    395 Rotenone 8 μg 12 hrs, larvae L3    546 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_19 mE1_20_mRNA_expression_cluster_01
External Data & Images
Linkouts	BDGP expression data • GH11331 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004363 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6647-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for porin Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Dcr-2Scer\UAS.cDa, Scer\GAL4e22c, Scer\GAL4sqh.PW porinKK107645 lethal (with porin1rev6) porink05123 porink08405 lethal (with porin1rev17) porink05123 porink08405 lethal (with porin1rev23) porink05123 porink08405 lethal (with porin2rev8) porink05123 porink08405 lethal (with porink05123) porin1rev6 porin1rev17 porin1rev23 porin2rev8 porink08405 lethal (with porink08405) porin1rev6 porin1rev17 porin1rev23 porin2rev8 porink05123 lethal | recessive porink05123 porink08405 partially lethal - majority die | larval stage | recessive porinRev8 viable porin2rev3 porinA2 porinf03616 Sterility Allele female fertile porinA2 porinEY2333 female semi-sterile | recessive porinRev8 fertile porinf03616 male fertile (with porin1rev2) porink05123 porink08405 male fertile (with porin1rev16) porink05123 porink08405 male fertile (with porin1rev18) porink05123 porink08405 male fertile (with porin1rev21) porink05123 porink08405 male fertile (with porin2rev2) porink05123 porink08405 male fertile (with porin2rev3) porink05123 porink08405 male fertile (with porin2rev7) porink05123 porink08405 male fertile (with porin2rev14) porink05123 porink08405 male fertile (with porink05123) porin1rev2 porin1rev16 porin1rev18 porin1rev21 porin2rev2 porin2rev3 porin2rev7 porin2rev14 male fertile (with porink08405) porin1rev2 porin1rev16 porin1rev18 porin1rev21 porin2rev2 porin2rev3 porin2rev7 porin2rev14 male semi-fertile porinEY2333 male sterile porinA2 male sterile (with porin2rev9) porink05123 porink08405 male sterile (with porink05123) porin2rev9 male sterile (with porink08405) porin2rev9 male sterile | recessive porinRev8 Other Phenotypes Allele bang sensitive porinEY2333 porinRev8 flight defective porinA2 locomotor behavior defective porinRev8 locomotor behavior defective (with porink05123) porink08405 locomotor behavior defective (with porink08405) porink05123 locomotor behavior defective | adult stage porinA2 locomotor behavior defective | recessive porink05123 porink08405 neurophysiology defective | larval stage porinRev8 neurophysiology defective | recessive porinG2294 short lived porinRev8 short lived (with porink05123) porink08405 short lived (with porink08405) porink05123 short lived | recessive porink05123 porink08405 Phenotype manifest in Allele cystic bulge porinA2 embryonic/larval neuromuscular junction porinRev8 indirect flight muscle porinunspecified porinA2 indirect flight muscle, with Scer\GAL4Mef2.PR porinScer\UAS.T:Zzzz\FLAG porindsRNA.Sym.Scer\UAS indirect flight muscle (with Df(2L)BSC143) porinA2 mitochondrion porinRev8 porinunspecified porinA2 mitochondrion, with Scer\GAL4Mef2.PR porinScer\UAS.T:Zzzz\FLAG porindsRNA.Sym.Scer\UAS mitochondrion (with Df(2L)BSC143) porinA2 Nebenkern porinA2 photoreceptor porinG2294 seminal vesicle porinRev8 testis porinRev8 waste bag porinA2
Classical Alleles ( 29 )
For All Classical Alleles Show
Allele of porin Class Mutagen Stocks Known lesion porinf03616 piggyBac transposase 2 -- porink05123 P-element activity 2 Yes porinG13650 P-element activity 1 -- porink08405 P-element activity 1 Yes porin1rev16 Delta2-3 0 Yes porin1rev17 Delta2-3 0 Yes porin1rev18 Delta2-3 0 Yes porin1rev21 Delta2-3 0 Yes porin1rev23 Delta2-3 0 Yes porin1rev2 Delta2-3 0 Yes porin1rev6 Delta2-3 0 Yes porin2rev14 Delta2-3 0 Yes porin2rev2 Delta2-3 0 Yes porin2rev3 Delta2-3 0 Yes porin2rev7 Delta2-3 0 Yes porin2rev8 Delta2-3 0 Yes porin2rev9 hypomorphic allele - genetic evidence Delta2-3 0 Yes porinA2 hypomorphic allele - molecular evidence P-element activity 0 Yes porinEx341 Delta2-3 0 Yes porinEx365 Delta2-3 0 Yes porinEx75 Delta2-3 0 Yes porinEx78 Delta2-3 0 Yes porinExS27 Delta2-3 0 Yes porinEY2333 0 -- porinG2294-R Delta2-3 0 Yes porinG2294 0 -- porinG2788 0 -- porinRev8 Delta2-3 0 Yes porinunspecified 0 --
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of porin Class Mutagen Stocks Known lesion porinJF03251 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes porinKK107645 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes porindsRNA.Sym.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes porinGD11991 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes porinNIG.6647R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes porinScer\UAS.cGa in vitro construct - regulatory fusion 0 Yes porinScer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(2L)J2 (Spradling et al., 1999) Df(2L)Prl (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Disrupted in	Df(2L)BSC230 (Christensen and Cook, 2006.12.5) Df(2L)Exel8026 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11991} NA P{KK107645} NA P{NIG.6647R} NA P{TRiP.JF03251} NA P{UAS-porin.FLAG} NA P{UAS-porin.G} NA P{UAS-porin.Sym} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{?lacW}porin1rev17 NA P{?lacW}porin1rev18 NA P{?lacW}porin1rev21 NA P{?lacW}porin2rev2 NA P{?lacW}porin2rev7 NA P{?lacW}porin2rev14 NA PBac{WH}porinf03616 NA insertion of enhancer trap P{lacW}l(2)SH0909SH0909 No P{lacW}porink05123 No P{lacW}porink08405 No insertion of mobile activating element P{EP}G6147 NA P{EP}porinG2294 NA P{EP}porinG2788 NA P{EP}porinG13650 NA P{EPgy2}porinEY2333 NA P{GSV1}C242C242 NA
Gene Ontology: Function, Process & Cellular Component ( 14 unique terms )
Terms Based on Experimental Evidence ( 10 terms )
Molecular Function
CV term Evidence References
voltage-gated anion channel activity inferred from direct assay (Komarov et al., 2004)
Biological Process
CV term Evidence References
ion transport inferred from direct assay (Komarov et al., 2004) mitochondrion organization inferred from mutant phenotype (Park et al., 2010) phototransduction inferred from mutant phenotype (Lee et al., 2007) sperm individualization inferred from mutant phenotype (Park et al., 2010) sperm mitochondrion organization inferred from mutant phenotype (Park et al., 2010)
Cellular Component
CV term Evidence References
lipid particle inferred from direct assay (Beller et al., 2006, Cermelli et al., 2006) microtubule associated complex inferred from direct assay (Hughes et al., 2008) mitochondrion inferred from direct assay (Park et al., 2010, Alonso et al., 2005) Nebenkern inferred from direct assay (Oliva et al., 2002)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
voltage-gated anion channel activity inferred from sequence or structural similarity (Swiss-Prot Project Members, 1999.4.15) inferred from sequence or structural similarity with EMBL:U30840 (FlyBase, 1992-) inferred from sequence or structural similarity with UniProtKB:P21796 (Sardiello et al., 2003.6.11)
Biological Process
CV term Evidence References
mitochondrial transport inferred from sequence or structural similarity (Swiss-Prot Project Members, 1999.4.15) inferred from sequence or structural similarity with UniProtKB:P21796 (Sardiello et al., 2003.6.11) regulation of anion transport inferred from electronic annotation with InterPro:IPR001925 (FlyBase Curators et al., 2004-) transmembrane transport inferred from electronic annotation with InterPro:IPR001925 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
mitochondrial outer membrane inferred from sequence or structural similarity with EMBL:U30840 (FlyBase, 1992-) inferred from sequence or structural similarity with UniProtKB:P21796 (Sardiello et al., 2003.6.11) non-traceable author statement (Spradling et al., 1999, Ryerse, 1996.9.10)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
porin - 5-HT7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - ATPsyn-Cf6 experimental knowledge based (Guruharsha et al., 2011) porin - ATPsyn-b experimental knowledge based (Guruharsha et al., 2011) porin - ATPsyn-β experimental knowledge based (Guruharsha et al., 2011) porin - ATPsyn-γ experimental knowledge based (Guruharsha et al., 2011) porin - Aats-asn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Ada anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - AnxB10 experimental knowledge based (Guruharsha et al., 2011) porin - Arf79F experimental knowledge based (Guruharsha et al., 2011) porin - Arp10 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Arp2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Arpc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Arpc2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Atg9 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Atx2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Bx42 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG1024 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG10413 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG10425 experimental knowledge based (Guruharsha et al., 2011) porin - CG10465 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG10581 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG10628 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG10934 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG1105 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG11200 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG11266 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG11279 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG11306 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG11317 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG11505 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG11697 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG11857 experimental knowledge based (Guruharsha et al., 2011) porin - CG12171 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG12200 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG12241 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG12262 experimental knowledge based (Guruharsha et al., 2011) porin - CG1227 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG1246 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG13021 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG13126 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG13295 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG13325 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG13532 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG13887 experimental knowledge based (Guruharsha et al., 2011) porin - CG14005 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG1441 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG1444 experimental knowledge based (Guruharsha et al., 2011) porin - CG1458 experimental knowledge based (Guruharsha et al., 2011) porin - CG14762 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG14969 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG15087 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG15098 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) porin - CG15118 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG15141 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG15576 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG15643 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG15735 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG1599 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG1688 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG1738 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG18081 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG18173 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG1907 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG2010 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG2021 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG2064 experimental knowledge based (Guruharsha et al., 2011) porin - CG2065 experimental knowledge based (Guruharsha et al., 2011) porin - CG2070 experimental knowledge based (Guruharsha et al., 2011) porin - CG2211 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG2519 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG2540 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG2574 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG2616 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG2789 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) porin - CG2921 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG2931 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG2938 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG30184 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG3045 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG30467 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG3088 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG31522 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG31523 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG31633 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG3164 experimental knowledge based (Guruharsha et al., 2011) porin - CG31675 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG32485 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG32512 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG3288 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG3303 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG33145 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG33253 experimental knowledge based (Guruharsha et al., 2011) porin - CG33303 experimental knowledge based (Guruharsha et al., 2011) porin - CG3689 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG3708 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG3793 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG3819 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG3835 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG3842 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG4091 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG4169 experimental knowledge based (Guruharsha et al., 2011) porin - CG4611 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG4612 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG4692 experimental knowledge based (Guruharsha et al., 2011) porin - CG4764 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG4797 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG4825 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG4968 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG5027 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG5080 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG5196 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG5382 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG5510 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG5646 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG5986 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG6282 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG6321 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG6330 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG6701 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG7091 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG7197 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG7272 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG7288 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG7655 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG7668 experimental knowledge based (Guruharsha et al., 2011) porin - CG7675 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG7881 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG7979 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG8004 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG8036 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG8117 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG8199 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG8311 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG8368 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG8602 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG8735 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG8888 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG8960 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG9231 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG9297 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG9386 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG9536 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG9547 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG9890 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CG9920 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Ca-P60A experimental knowledge based (Guruharsha et al., 2011) porin - Cbp80 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Ccp84Ac anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Cct2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Chc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Chd64 experimental knowledge based (Guruharsha et al., 2011) porin - Ciao1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CkIIβ2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - CoIV experimental knowledge based (Guruharsha et al., 2011) porin - Cog3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Corp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Cpr11A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Ctr1B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Cyp28c1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Cyp28d1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Cyp308a1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Cyp4ad1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Cyp4d2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Cyp6a22 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Dp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - E(spl)mγ-HLH anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Eno experimental knowledge based (Guruharsha et al., 2011) porin - Ent2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Esp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Fatp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Flo-2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Fmo-2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Ge-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Gp93 experimental knowledge based (Guruharsha et al., 2011) porin - Gαi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - HPS1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Hex-A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Hip1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Hip14 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Hsp83 experimental knowledge based (Guruharsha et al., 2011) porin - Iap2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - ImpL3 experimental knowledge based (Guruharsha et al., 2011) porin - JhI-21 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Jon44E anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Jon65Ai anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - KdelR experimental knowledge based (Guruharsha et al., 2011) porin - Kdm4A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Khc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Kr-h2 experimental knowledge based (Guruharsha et al., 2011) porin - Lac anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Lapsyn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - M6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - MESK2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - MFS3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - MRP experimental knowledge based (Guruharsha et al., 2011) porin - Map205 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Mec2 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) porin - Men anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Mf experimental knowledge based (Guruharsha et al., 2011) porin - Mkk4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Mlc1 experimental knowledge based (Guruharsha et al., 2011) porin - Mlc2 experimental knowledge based (Guruharsha et al., 2011) porin - Mlf anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Mo25 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Ndae1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Ndfip anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Nmt anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Nos anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Nup107 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Oamb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Oscp experimental knowledge based (Guruharsha et al., 2011) porin - Ost48 experimental knowledge based (Guruharsha et al., 2011) porin - OstΔ experimental knowledge based (Guruharsha et al., 2011) porin - P32 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - PHGPx anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) porin - Pdi experimental knowledge based (Guruharsha et al., 2011) porin - Pis anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Pk17E anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Rab2 experimental knowledge based (Guruharsha et al., 2011) porin - Rab5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Rab6 experimental knowledge based (Guruharsha et al., 2011) porin - Rap2l experimental knowledge based (Guruharsha et al., 2011) porin - RhoBTB anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - RhoGEF4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - RpL35A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - RpL37a anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - RpS12 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Rpn3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Rpn6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Rpn9 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Rpp30 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Rtnl1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Sc2 experimental knowledge based (Guruharsha et al., 2011) porin - Sdc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - SmD2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - SmD3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - SmF anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Snap anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Socs44A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Sox21a anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Sply anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - SsRβ experimental knowledge based (Guruharsha et al., 2011) porin - Su(var)2-10 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Sucb experimental knowledge based (Guruharsha et al., 2011) porin - Surf4 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) porin - Syb experimental knowledge based (Guruharsha et al., 2011) porin - Syx1A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - TH1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Tapδ experimental knowledge based (Guruharsha et al., 2011) porin - Tg anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Tm1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Tm2 experimental knowledge based (Guruharsha et al., 2011) porin - Tps1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Tsp29Fb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Tsp42El anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Vap-33-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - Vha68-2 experimental knowledge based (Guruharsha et al., 2011) porin - Wwox anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - ZnT63C experimental knowledge based (Guruharsha et al., 2011) porin - aur anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - blp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - blw experimental knowledge based (Guruharsha et al., 2011) porin - bys anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - dysb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - ebd1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - exba anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - fax experimental knowledge based (Guruharsha et al., 2011) porin - fd59A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - frc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - frj anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - fwe anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - fz anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - fzr2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - gk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - ihog anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - ine anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - isoQC anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - l(1)G0230 experimental knowledge based (Guruharsha et al., 2011) porin - l(2)03709 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) porin - l(2)37Cc experimental knowledge based (Guruharsha et al., 2011) porin - mRpL15 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - mRpL39 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - mRpL4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - mRpL44 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - mRpS24 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - mTerf3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - mol anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - mthl3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - nemy anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - nes anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - olf186-F anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - out anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - ox experimental knowledge based (Guruharsha et al., 2011) porin - oys anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - p130CAS anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - p38b anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - papi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - pigeon anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - qkr58E-3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - rdhB anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - regucalcin anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) porin - rev7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - rho anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - sip3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - spi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - stv anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - tkv anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - tomboy20 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - tor anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - trpml anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - tyn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - up experimental knowledge based (Guruharsha et al., 2011) porin - vps2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - wal experimental knowledge based (Guruharsha et al., 2011) porin - wls anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - βggt-II anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) porin - εCOP anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions porin allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60572 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0004363 DroID - A comprehensive database of gene and protein interactions. • FBgn0004363 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34500
Orthologs
OrthoDB Orthologs (60) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6VHKSK Dipteran inclusive ortholog search EOG69601P Insect inclusive ortholog search EOG6F4R6V Arthropod inclusive ortholog search EOG6KD52V Metazoa inclusive ortholog search EOG657J1Q
Orthologs in Drosophila Species (EOG6VHKSK)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\porin     Drosophila simulans   Dsim\GD22218 Y   Drosophila sechellia   Dsec\GM11358 Y   Drosophila erecta   Dere\GG10349 Y   Drosophila yakuba   Dyak\porin Y   Drosophila ananassae   Dana\GF14059 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19750 Y   Drosophila persimilis   Dper\GL26379 Y   Drosophila willistoni   Dwil\GK23973 Y   Drosophila virilis   Dvir\GJ17632 Y   Drosophila mojavensis   Dmoj\GI17807 Y   Drosophila grimshawi   Dgri\GH13331 Y
Orthologs in non-Drosophila Dipterans (EOG69601P)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\VDAC   Anopheles gambiae Malaria mosquito  Agam\VDAC   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ000967
Orthologs in non-Dipteran Insects (EOG6F4R6V)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\porin   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG003981   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH11679   Atta cephalotes Leafcutter ant  Acep\ACEP18954   Atta cephalotes Leafcutter ant  Acep\ACEP17867   Camponotus floridanus Florida carpenter ant  Cflo\CFLO18965   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16847   Linepithema humile Argentine ant  Lhum\LH25016   Pogonomyrmex barbatus Red harvester ant  Pbar\PB21712   Solenopsis invicta Red fire ant  Sinv\SINV17905   Acyrthosiphon pisum Pea aphid  Apim\ACYPI000248   Bombyx mori Silkmoth  Bmor\BGIBMGA008955   Pediculus humanus Human body louse  Phum\PHUM472560   Tribolium castaneum Red flour beetle  Tcas\TC006408
Orthologs in non-Insect Arthropods (EOG6KD52V)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\EAPA   Ixodes scapularis Deer tick  Isca\ISCW000781
Orthologs in non-Arthropod Metazoa (EOG657J1Q)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\R05G6.7 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027236gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015257gn Y Danio rerio Zebrafish  Drer\CH211-220D9.2 Y Danio rerio Zebrafish  Drer\vdac1 Y Danio rerio Zebrafish  Drer\vdac2 Y Danio rerio Zebrafish  Drer\ENSDARG00000073775 Y Danio rerio Zebrafish  Drer\zgc:56235 Y Xenopus tropicalis Western clawed frog  Xtro\vdac1 Y Xenopus tropicalis Western clawed frog  Xtro\vdac3 Y Xenopus tropicalis Western clawed frog  Xtro\vdac2 Y Gallus gallus Domestic chicken  Ggal\VDAC1 Y Gallus gallus Domestic chicken  Ggal\VDAC3 Y Gallus gallus Domestic chicken  Ggal\VDAC2 Y Mus musculus House mouse  Mmus\ENSMUSG00000020402 Y Mus musculus House mouse  Mmus\Vdac2 Y Mus musculus House mouse  Mmus\Vdac3 Y Rattus norvegicus Norway rat  Rnor\Vdac2 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000040107 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000011812 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000015854 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000026308 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000042832 Y Rattus norvegicus Norway rat  Rnor\Vdac1 Y Rattus norvegicus Norway rat  Rnor\Vdac1 Y Rattus norvegicus Norway rat  Rnor\Vdac3 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000029794 Y Homo sapiens Human  Hsap\ENSG00000165637 Y Homo sapiens Human  Hsap\VDAC1 Y
Human Orthologs (2)
Gene OMIM HGNC Hsap\ENSG00000165637     Hsap\VDAC1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD22218 Drosophila sechellia Dsec\GM11358 Drosophila erecta Dere\GG10349 Drosophila yakuba Dyak\porin Drosophila ananassae Dana\GF14059 Drosophila pseudoobscura pseudoobscura Dpse\GA19750 Drosophila persimilis Dper\GL26379 Drosophila willistoni Dwil\GK23973 Drosophila virilis Dvir\GJ17632 Drosophila mojavensis Dmoj\GI17807 Drosophila grimshawi Dgri\GH13331
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	18676 w1118; PBac{WH}porinf03616 28403 y1 w*; P{EP}porinG13650 10563 y1 w67c23; P{lacW}porink05123/CyO 29572 y1 v1; P{TRiP.JF03251}attP2/TM3, Sb1
Harvard	- PBac{WH}porinf03616
Kyoto	102643 y1 w67c23 ; P{lacW}porink08405 / CyO 111174 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{lacW}porink05123 P{neoFRT}40A/CyO y+
VDRC	v101336 P{KK107645}VIE-260B
Genomic Clones ( 2 )
	BACR03D06 BACR19N18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 410 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH11331 IP15876
Other clones	DPiM_GH11331
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT10727 AT10827 AT15865 AT17001 AT22911 AT24461 GH01466 GH02406 GH04671 GH05545 GH05816 GH08586 GH08589 GH11152 GH11773 GH11785 GH11833 GH12237 GH12618 GH15571 GH16103 GH16649 GH16724 GH16827 GH16991 GH17324 GH18730 GH23693 GH25119 GH25779 GH26018 GH26522 GM01541 GM02367 GM04204 GM04220 GM07752 GM08376 GM10216 GM13532 GM14689 GM15086 GM15388 GM17012 GM17557 GM17823 GM19131 GM22584 GM22996 GM23696 GM25392 GM28647 GM29551 LD02022 LD05203 LD08776 LD09080 LD12693 LD13360 LD18378 LD20193 LD21591 LD24647 LD28880 LD30133 LD31188 LD31192 LD32286 LD36607 LD38780 LD39691 LD39874 LD40988 LD42447 LD42755 LD46196 LD47784 LP02785 LP03503 LP03853 LP05102 LP05967 LP06485 LP07335 LP07536 LP07831 LP14193 LP16103 LP17879 LP18230 LP19115 LP19361 LP21816 RE12990 RE16195 RE16923 RE18726 RE18996 RE21690 RE23123 RE33373 RE35363 RE39572 RE39793 RE47117 RE53002 RE56641 RE56936 RE62821 RE72587 RH14802 RH31376 RH38737 RH39703 RH45163 RH46528 RH46960 RH47210 RH51913 RH55475 RH56922 RH65939 RH66360 RH67914 RH72984 RH74260 SD02321 SD03675 SD06912 SD07277 SD10324 SD11275 SD11329 SD12052 SD12551 SD12804 SD12846 SD12875 SD13383 SD13568 SD14340 SD15402 SD15509 SD16908 SD17417 SD17430 SD17631 SD19459 SD19594 SD20334 SD20935 SD22549 SD22685 SD22996 SD26205 SD26233 SD26790 SD28056
Other clones	62546 72846 108699 158391 165484 bs25h05 bs46a08 bs46h05 bs80a06 CK01.2C.C8 CK01.64C.B8 CK01.111A.B10 Dmel_dig_007614_0711_2567 Dmel_dig_007758_0662_3724 Dmel_dig_011553_0601_1963 Dmel_dig_013205_0667_3052 Dmel_dig_017302_0639_1167 Dmel_neb_008854_0612_1396 Dmel_neb_009409_0184_0406 Dmel_neb_009887_0595_0773 Dmel_neb_010759_0582_0669 Dmel_neb_011679_0933_1732 Dmel_neb_011793_0687_0673 Dmel_neb_012857_0886_1223 Dmel_neb_013451_0927_2133 Dmel_neb_013735_0663_1193 Dmel_neb_014581_0192_0781 EC13835 EC29221 EC32141 EC36786 EK000238 EK028004 EK043406 EK053428 EK055601 EK065126 EK065601 EK107509 EK116147 EK164807 EK168258 EK169937 EK188232 EK196907 EK205261 EK212107 EK235443 EK261241 EK266353 EK270046 EK299829 EN03639 EN14850 FGH124C06 FGM002C07 FGM217E08 FGM302D04 FGM309F02 GH05864 GH19152 GH24756 GM13853 LP21773 RE01540 RE01682 RE01690 RE01986 RE08560 RE09110 RE12963 RE13131 RE14006 RE14815 RE15127 RE18724 RE24612 RE24675 RE25427 RE25947 RE28890 RE29356 RE29495 RE30235 RE32042 RE36681 RE38872 RE38908 RE40265 RE42112 RE44059 RE45487 RE47066 RE49635 RE49670 RE49695 RE49918 RE50528 RE52893 RE53455 RE57805 RE58343 RE60339 RE65545 RE65974 RE66394 RE66955 RE69563 RE70166 RE70452 RE71806 RE74482 RH07832 RH09077 RH10756 RH22218 RH23049 RH23671 RH23990 RH24313 RH25638 RH29968 RH35158 RH36129 RH36595 RH37373 RH39009 RH39165 RH39591 RH40485 RH42948 RH43194 RH45402 RH49738 RH51819 RH52429 RH54585 RH56184 RH56925 RH59263 RH59833 RH61122 RH61176 RH63656 RH63895 RH64165 RH64648 RH65133 RH66176 RH67865 RP003006915 RP003012535 RP003014011 RP003025928 RP003030223 RP003038317 RP003062585 RP003063455 RP003063762 RP003072134 RP003075574 RP003080051 RP003085782 RP003088375 RP003089694 RP003091933 RP003101232 RP003107780 RP003111985 RP003114489 RP003118874 RP003131729 RP003135873 RP003137814 RP003138725 RP003143951 RP003164124 RP003164309 RP003174439 RP003175583 RP003177584 RP003179453 RP003183107 RP003184475 RP003185762 RP003187538 RP003191510 RP003194528 RP003196916 RP003199459 RP003213266 RP003235081 RP003258029 RP003258084 RP003258378 RP003265074 RP003270405 RP003270854 RP003277320 RP003283057 RP003290358 RP003302949 RP003315194 RP003319232 RP003332460 RP003352773 RP003372803 RP003386302 RP003388417 RP003416339 RP003427009 RP003429957 RP003442508 RP003455907 RP003464689 RP003465220 RP003467476 RP003477694 RP003486402 RP003495324 RP003503641 RP003514612 RP003515842 RP003521548 RP003522102 RP003522777 RP003528155 RP003539104 RP003546576 RP003548769 RP003550156 RP003557125 RP003559607 RP003564789 RP003565626 RP003566455 RP003573014 RP003575229 RP003579857 RP003585724 RP003632480 RP003643554 RP003666454 RP003674971 SD12138 UT01693 UT01730 UUGC0169 UUGC1002
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004363 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34500
Antibody Information
	polyclonal (Oliva et al., 2002, Park et al., 2010)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: porin CG6647 (Li, 1999.11)
Source for database merge of	Source for merge of: porin anon-WO02059370.56 (FlyBase, 1996-) Source for merge of: porin l(2)k05123 (Spradling et al., 1999)
Additional comments	Source for merge of porin anon-WO02059370.56 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	porin encodes a voltage-dependent and anion-selective channel. (Aiello et al., 2004) porin has been cloned and sequenced. It has been isolated from an expression library using an antibody against tobacco hornworm VDAC protein as a probe. Comparison of DNA sequence with that from FBrf0087605 reveals there is one porin gene, and two isolated cDNAs. (Ryerse et al., 1997) porin cDNA is isolated and characterised. Present results suggest porin may be a member of a multigene family. (Messina et al., 1996) porin has been characterised and compared to other mitochondrial porins. (de Pinto et al., 1989)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057465 NM_134283 NM_001038810 NM_001259032 NM_001273436 RefSeq (Proteins) • NP_476813 NP_599110 NP_001033899 NP_001245961 NP_001260365 DDBJ / EMBL / GenBank • AAC02635 AAF53022 AAF53022.1 AAL47980 AAN10766 AAN10766.1 ABC65894 AC007186 AF121361 AFH03635 AGB92900 AI109404 AI134001 AI543533 AI946440 AJ000880 AQ034146 AW940403 AX664482 AY070509 CAA04370 CAA63143 CAA64988 CZ486190 CZ486191 U70314 X92408 X95692 Entrez Gene - A searchable database of RefSeq genes. • 34500 UniProtKB/Swiss-Prot • Q94920
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Porin, eukaryotic type (IPR001925) Eukaryotic porin/Tom40 (IPR027246) Porin domain (IPR023614) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME06647 BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH11331
Linkouts
	BioGRID - A database of protein and genetic interactions • 60572 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0004363 DroID - A comprehensive database of gene and protein interactions. • FBgn0004363 DRSC - Results from RNAi screens. • FBgn0004363 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004363 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6647-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004363 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34500 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34500 modMine - Data generated by the modENCODE project. • FBgn0004363
Synonyms & Secondary IDs ( 17 )
Reported As
Symbol Synonym	anon-WO02059370.56   CG6647 (Regulski et al., 2004, Cermelli et al., 2006, Terhzaz et al., 2006, Guarino et al., 2006, Molnar et al., 2006, Keleman et al., 2009.8.5, Perkins et al., 2009, Hughes et al., 2008, Cammarato et al., 2011, Tsubouchi et al., 2012) cg6647 (Park et al., 2010) DmPorin1 (Aiello et al., 2004) DmVDAC (Blachly-Dyson et al., 1997, Ryerse et al., 1997) DVDAC (Komarov et al., 2004) l(2)k05123 (Mesilaty-Gross et al., 1999, BDGP Project Members, 1994-1999, ) POR-1 (Vito, 1997.7.29, ) porin (Beller et al., 2006, Christensen and Cook, 2006.12.5, Lee et al., 2007, Terhzaz et al., 2006, Molnar et al., 2006, Kaltenbach et al., 2007, Peralta et al., 2012, Graham et al., 2010, Park et al., 2010, Wasbrough et al., 2010, Groebe et al., 2010, Tsubouchi et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Duboff et al., 2012) Porin (Peralta et al., 2012, Robinson et al., 2010) PORIN (Alonso et al., 2005) VDAC (Ryerse, 1996.9.10, Oliva et al., 1998, Rival et al., 2011, Park et al., 2010, Komarov et al., 2004) Vdac
Name Synonym	mitochondrial porin (Komarov et al., 2004) porin (Guarino et al., 2006, Kaltenbach et al., 2007, Graham et al., 2010, Sun et al., 2011, Craigen and Graham, 2008, Cammarato et al., 2011, Tsubouchi et al., 2012) Porin (Pedersen et al., 2010, Robinson et al., 2010) Porin 1 (Guarino et al., 2006) porin 1 (Specchia et al., 2008) Voltage-dependent anion-selective channel
Secondary FlyBase IDs
	FBgn0016759 FBgn0022189 FBgn0024919 FBgn0066003
References ( 80 )
Generate a list of	All references relating to this gene ( 80 )
List References by type	Research paper  ( 36 ) Supplementary material  ( 11 ) Review  ( 4 ) Personal communication to FlyBase  ( 15 ) Abstract  ( 1 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 4 ) Stock list  ( 1 ) Curated genome annotation  ( 3 ) Patent  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 )
Recent research papers ( 4 )
	Duboff et al., 2012, Neuron 75(4): 618--632 Tau Promotes Neurodegeneration via DRP1 Mislocalization In Vivo. [FBrf0219271] Peralta et al., 2012, J. Biol. Chem. 287(29): 24174--24185 Coiled Coil Domain-containing Protein 56 (CCDC56) Is a Novel Mitochondrial Protein Essential for Cytochrome c Oxidase Function. [FBrf0218928] Rival et al., 2011, EMBO Rep. 12(3): 223--230 Inner-membrane proteins PMI/TMEM11 regulate mitochondrial morphogenesis independently of the DRP1/MFN fission/fusion pathways. [FBrf0213174] Sun et al., 2011, PLoS ONE 6(4): e18215 Systems-scale analysis reveals pathways involved in cellular response to methamphetamine. [FBrf0213560] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...