• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\mei-41

General Information
Symbol	Dmel\mei-41	Species	D. melanogaster
Name	meiotic 41	Annotation symbol	CG4252
Feature type	protein_coding_gene	FlyBase ID	FBgn0004367
Gene Model Status	Current	Stock availability	52 publicly available
Also Known As	mei41, ATR, mus104, mus103, mus(1)104, fs(1)M37, mus-104, mus(1)103
Genomic Location
Chromosome (arm)	X	Recombination map	1-54.2
Cytogenetic map	14C3-14C3	Sequence location	X:16,285,794..16,293,601 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene meiotic 41 is referred to in FlyBase by the symbol Dmel\mei-41 (CG4252, FBgn0004367). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: kinase activity. There is experimental evidence for 14 unique biological process terms, many of which group under: biological regulation; cell cycle; cellular process involved in reproduction; cellular component organization or biogenesis; cellular macromolecule metabolic process; M phase of meiotic cell cycle; regulation of biological process; response to DNA damage stimulus; cell cycle process; nucleic acid metabolic process. 65 alleles are reported. The phenotypes of these alleles are annotated with: cycle 13 embryo; wing disc; presumptive oocyte; spindle; cycle 14 embryo. It has one annotated transcript and one annotated polypeptide. Protein features are: Armadillo-type fold; PIK-related kinase; PIK-related kinase, FAT; PIK-related kinase, FATC; Phosphatidylinositol 3-/4-kinase, catalytic; Phosphatidylinositol 3/4-kinase, conserved site; Protein kinase-like domain; Tetratricopeptide-like helical; UME. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1635747_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of mei-41. Gene sequence location is X:16285794..16293601.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	mei-41 (R.S. Hawley) mei-41 alleles confer sensitivity to mutagens as a consequence of a defect in a caffeine-sensitive post-replication repair pathway (Boyd and Setlow, 1976; Boyd et al., 1976; Boyd and Shaw, 1982). This defect in DNA repair is also manifested by a high frequency of mitotic chromosome breakage and instability (Baker et al., 1978; Gatti, 1979). mei-411 not hypermutable to alkylation nor defective in excision repair; yet mei-41D12 displays hypermutability to alkylation and defective alkylation excision repair (Smith and Dusenberry, 1988, Mechanisms and Consequences of DNA Damage Processing, Alan R. Liss, Inc., pp. 251-55). Allelism based on lack of complementation (Mason, Scobie, and Yamamoto, 1989, Mol. Gen. Genet. 215: 190-99). Most alleles of mei-41 also reduce female fertility and in some cases are female-sterile as homozygotes. Females homozygous for the more fertile alleles of mei-41 exhibit reduced levels of meiotic exchange. The observed reductions in exchange are not uniform, but rather are most extreme in distal regions. Chiasma interference is also diminished (Carpenter and Sandler, 1974; Baker and Hall, 1976). These reduced levels of exchange allow for high frequencies of meiotic loss and nondisjunction (see Baker and Hall, 1976). Ultrastructural analysis of pachytene in mei-41 and mei-412 females demonstrates a reduced number of late recombination nodules which are distributed in a fashion that parallels residual exchange events (Carpenter, 1979). Over half of those nodules which are observed are morphologically abnormal and are associated with unusual regions of relatively uncondensed chromatin. Stocks in which mei-41 is carried in the male are frequently observed to carry or acquire a bb mutation on the mei-41-bearing X chromosome (Hawley and Tartof, 1983). Several alleles of mei-41 have also been shown to inhibit rDNA magnification in the male germline (Hawley and Tartof, 1983; Hawley et al., 1985). Moreover, mei-41 males undergoing magnification also produce a high frequency of X-Y exchanges which result from one break within the X-chromosome rDNA cluster and the other at any of a large number of sites on the Y chromosome (Hawley and Tartof, 1983).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features BKN50321 BKN50035 BKN21843 HFA20350 References Chiolo et al., 2011, Cell 144(5): 732--744
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 14C3-14C3   Limits computationally determined from genome sequence between P{EP}EP1493EP1493 and P{EP}EP1547EP1547
Experimentally Determined Cytological Location
Cytogenetic map Notes References 14C-14C   (determined by in situ hybridisation)   (Peter et al., 2002) 14C4-14C6   (determined by in situ hybridisation)   (Boyd et al., 1990) 14C4-14C6   (determined by in situ hybridisation)   (Yamamoto et al., 1990)
Experimentally Determined Recombination Data
Location	1-54.2 (Gatti, 1979) 1- (Smith, 1976, Mohler, 1977)
Left of (cM)	f (Mohler, 1977)
Right of (cM)	mei-9 (Smith, 1976) v (Mohler, 1977)
Notes	Maps near 1-54. (Smith, 1976) mei-41D14 maps approximately 0.05 units to the left of mei-41D5. (Mason et al., 1981) mei-41RT1 is located 0.04 map units to the right of mei-41D14 and 0.02 map units to the left of mei-41D9. mei-41RT2 is located 0.06 map units to the right of mei-41D14 and 0.03 map units to the right of mei-41D9. (Yamamoto et al., 1990)
Gene Model & Products
Please see the GBrowse view of Dmel\mei-41 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) mei-41-RA FBtr0074271  NM_078645   7554   2517
Additional Transcript Data & Comments
Reported size (kB)	8.3 (northern blot) (Hari et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein mei-41-PA   FBpp0074047   289.3   2517   7.58     NP_523369   AAF48604
Additional Polypeptide Data & Comments
Reported size (kDa)	2354 (aa) (Hari et al., 1995)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Phosphatidylinositol 3/4-kinase, conserved site (IPR018936) Phosphatidylinositol 3-/4-kinase, catalytic (IPR000403) PIK-related kinase, FAT (IPR003151) PIK-related kinase, FATC (IPR003152) Protein kinase-like domain (IPR011009) UME (IPR012993) PIK-related kinase (IPR014009) Armadillo-type fold (IPR016024) Tetratricopeptide-like helical (IPR011990)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF48604   AY282465 AAQ22732   CZ480204   EC055077   U34925 AAC46881   Z31938   Z31965
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VXG8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference oogenesis & adult stage | female   ovary   (Hari et al., 1995)
Additional Descriptive Data
	mei-41 transcripts are detected in RNA from ovaries. (Hari et al., 1995)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0004367    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0004367 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0004367 expression level Developmental Stage   Expression Level embryo 00-02hr    1009 embryo 02-04hr    280 embryo 04-06hr    616 embryo 06-08hr    345 embryo 08-10hr    228 embryo 10-12hr    116 embryo 12-14hr    97 embryo 14-16hr    99 embryo 16-18hr    43 embryo 18-20hr    26 embryo 20-22hr    32 embryo 22-24hr    31 larva L1    134 larva L2    108 larva L3 12hr old    85 larva L3 puffstage 1-2    121 larva L3 puffstage 3-6    204 larva L3 puffstage 7-9    204 white prepupae new    190 white prepupae 12hr    231 white prepupae 24hr    299 pupae 2d postWPP    130 pupae 3d postWPP    42 pupae 4d postWPP    55 adult male 01day    72 adult male 05day    92 adult male 30day    108 adult female 01day    389 adult female 05day    686 adult female 30day    724 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1009) embryo 02-04hr  (280) embryo 04-06hr  (616) embryo 06-08hr  (345) embryo 08-10hr  (228) embryo 10-12hr  (116) embryo 12-14hr    97 embryo 14-16hr    99 embryo 16-18hr    43 embryo 18-20hr    26 embryo 20-22hr    32 embryo 22-24hr    31 larva L1  (134) larva L2  (108) larva L3 12hr old    85 larva L3 puffstage 1-2  (121) larva L3 puffstage 3-6  (204) larva L3 puffstage 7-9  (204) white prepupae new  (190) white prepupae 12hr  (231) white prepupae 24hr  (299) pupae 2d postWPP  (130) pupae 3d postWPP    42 pupae 4d postWPP    55 adult male 01day    72 adult male 05day    92 adult male 30day  (108) adult female 01day  (389) adult female 05day  (686) adult female 30day  (724) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1009 embryo 02-04hr    280 embryo 04-06hr    616 embryo 06-08hr    345 embryo 08-10hr    228 embryo 10-12hr    116 embryo 12-14hr    97 embryo 14-16hr    99 embryo 16-18hr    43 embryo 18-20hr    26 embryo 20-22hr    32 embryo 22-24hr    31 larva L1    134 larva L2    108 larva L3 12hr old    85 larva L3 puffstage 1-2    121 larva L3 puffstage 3-6    204 larva L3 puffstage 7-9    204 white prepupae new    190 white prepupae 12hr    231 white prepupae 24hr    299 pupae 2d postWPP    130 pupae 3d postWPP    42 pupae 4d postWPP    55 adult male 01day    72 adult male 05day    92 adult male 30day    108 adult female 01day    389 adult female 05day    686 adult female 30day    724 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1009 embryo 02-04hr    280 embryo 04-06hr    616 embryo 06-08hr    345 embryo 08-10hr    228 embryo 10-12hr    116 embryo 12-14hr    97 embryo 14-16hr    99 embryo 16-18hr    43 embryo 18-20hr    26 embryo 20-22hr    32 embryo 22-24hr    31 larva L1    134 larva L2    108 larva L3 12hr old    85 larva L3 puffstage 1-2    121 larva L3 puffstage 3-6    204 larva L3 puffstage 7-9    204 white prepupae new    190 white prepupae 12hr    231 white prepupae 24hr    299 pupae 2d postWPP    130 pupae 3d postWPP    42 pupae 4d postWPP    55 adult male 01day    72 adult male 05day    92 adult male 30day    108 adult female 01day    389 adult female 05day    686 adult female 30day    724 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1009 embryo 02-04hr    280 embryo 04-06hr    616 embryo 06-08hr    345 embryo 08-10hr    228 embryo 10-12hr    116 embryo 12-14hr    97 embryo 14-16hr    99 embryo 16-18hr    43 embryo 18-20hr    26 embryo 20-22hr    32 embryo 22-24hr    31 larva L1    134 larva L2    108 larva L3 12hr old    85 larva L3 puffstage 1-2    121 larva L3 puffstage 3-6    204 larva L3 puffstage 7-9    204 white prepupae new    190 white prepupae 12hr    231 white prepupae 24hr    299 pupae 2d postWPP    130 pupae 3d postWPP    42 pupae 4d postWPP    55 adult male 01day    72 adult male 05day    92 adult male 30day    108 adult female 01day    389 adult female 05day    686 adult female 30day    724 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0004367 expression level Developmental Stage   Expression Level embryo 00-02hr    1009 embryo 02-04hr    280 embryo 04-06hr    616 embryo 06-08hr    345 embryo 08-10hr    228 embryo 10-12hr    116 embryo 12-14hr    97 embryo 14-16hr    99 embryo 16-18hr    43 embryo 18-20hr    26 embryo 20-22hr    32 embryo 22-24hr    31 larva L1    134 larva L2    108 larva L3 12hr old    85 larva L3 puffstage 1-2    121 larva L3 puffstage 3-6    204 larva L3 puffstage 7-9    204 white prepupae new    190 white prepupae 12hr    231 white prepupae 24hr    299 pupae 2d postWPP    130 pupae 3d postWPP    42 pupae 4d postWPP    55 adult male 01day    72 adult male 05day    92 adult male 30day    108 adult female 01day    389 adult female 05day    686 adult female 30day    724 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1009) embryo 02-04hr  (280) embryo 04-06hr  (616) embryo 06-08hr  (345) embryo 08-10hr  (228) embryo 10-12hr  116 embryo 12-14hr    97 embryo 14-16hr    99 embryo 16-18hr    43 embryo 18-20hr    26 embryo 20-22hr    32 embryo 22-24hr    31 larva L1  134 larva L2  108 larva L3 12hr old    85 larva L3 puffstage 1-2  121 larva L3 puffstage 3-6  (204) larva L3 puffstage 7-9  (204) white prepupae new  (190) white prepupae 12hr  (231) white prepupae 24hr  (299) pupae 2d postWPP  130 pupae 3d postWPP    42 pupae 4d postWPP    55 adult male 01day    72 adult male 05day    92 adult male 30day  108 adult female 01day  (389) adult female 05day  (686) adult female 30day  (724) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1009 embryo 02-04hr    280 embryo 04-06hr    616 embryo 06-08hr    345 embryo 08-10hr    228 embryo 10-12hr    116 embryo 12-14hr    97 embryo 14-16hr    99 embryo 16-18hr    43 embryo 18-20hr    26 embryo 20-22hr    32 embryo 22-24hr    31 larva L1    134 larva L2    108 larva L3 12hr old    85 larva L3 puffstage 1-2    121 larva L3 puffstage 3-6    204 larva L3 puffstage 7-9    204 white prepupae new    190 white prepupae 12hr    231 white prepupae 24hr    299 pupae 2d postWPP    130 pupae 3d postWPP    42 pupae 4d postWPP    55 adult male 01day    72 adult male 05day    92 adult male 30day    108 adult female 01day    389 adult female 05day    686 adult female 30day    724 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1009 embryo 02-04hr    280 embryo 04-06hr    616 embryo 06-08hr    345 embryo 08-10hr    228 embryo 10-12hr    116 embryo 12-14hr    97 embryo 14-16hr    99 embryo 16-18hr    43 embryo 18-20hr    26 embryo 20-22hr    32 embryo 22-24hr    31 larva L1    134 larva L2    108 larva L3 12hr old    85 larva L3 puffstage 1-2    121 larva L3 puffstage 3-6    204 larva L3 puffstage 7-9    204 white prepupae new    190 white prepupae 12hr    231 white prepupae 24hr    299 pupae 2d postWPP    130 pupae 3d postWPP    42 pupae 4d postWPP    55 adult male 01day    72 adult male 05day    92 adult male 30day    108 adult female 01day    389 adult female 05day    686 adult female 30day    724 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1009 embryo 02-04hr    280 embryo 04-06hr    616 embryo 06-08hr    345 embryo 08-10hr    228 embryo 10-12hr    116 embryo 12-14hr    97 embryo 14-16hr    99 embryo 16-18hr    43 embryo 18-20hr    26 embryo 20-22hr    32 embryo 22-24hr    31 larva L1    134 larva L2    108 larva L3 12hr old    85 larva L3 puffstage 1-2    121 larva L3 puffstage 3-6    204 larva L3 puffstage 7-9    204 white prepupae new    190 white prepupae 12hr    231 white prepupae 24hr    299 pupae 2d postWPP    130 pupae 3d postWPP    42 pupae 4d postWPP    55 adult male 01day    72 adult male 05day    92 adult male 30day    108 adult female 01day    389 adult female 05day    686 adult female 30day    724 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0004367    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0004367 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0004367 expression level Tissue   Expression Level Larval Central Nervous System    31.175 Larval Midgut    3.6 Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    18.9 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    8.2 Adult Hindgut    8.2 Adult Malpighian Tubules    4.6 Adult Fat Body no informative data Adult Salivary Gland    6.3 Adult Heart    11.6 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    9.8 Adult Ovary    56 Adult Testis    6.5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    31.175 Larval Midgut    3.6 Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    18.9 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    8.2 Adult Hindgut    8.2 Adult Malpighian Tubules    4.6 Adult Fat Body no informative data Adult Salivary Gland    6.3 Adult Heart    11.6 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    9.8 Adult Ovary    56 Adult Testis    6.5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    31.175 Larval Midgut    3.6 Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    18.9 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    8.2 Adult Hindgut    8.2 Adult Malpighian Tubules    4.6 Adult Fat Body no informative data Adult Salivary Gland    6.3 Adult Heart    11.6 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    9.8 Adult Ovary    56 Adult Testis    6.5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    31.175 Larval Midgut    3.6 Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    18.9 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    8.2 Adult Hindgut    8.2 Adult Malpighian Tubules    4.6 Adult Fat Body no informative data Adult Salivary Gland    6.3 Adult Heart    11.6 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    9.8 Adult Ovary    56 Adult Testis    6.5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0004367 expression level Tissue   Expression Level Larval Central Nervous System    31.175 Larval Midgut    3.6 Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    18.9 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    8.2 Adult Hindgut    8.2 Adult Malpighian Tubules    4.6 Adult Fat Body no informative data Adult Salivary Gland    6.3 Adult Heart    11.6 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    9.8 Adult Ovary    56 Adult Testis    6.5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    31.175 Larval Midgut    3.6 Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    18.9 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    8.2 Adult Hindgut    8.2 Adult Malpighian Tubules    4.6 Adult Fat Body no informative data Adult Salivary Gland    6.3 Adult Heart    11.6 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    9.8 Adult Ovary    56 Adult Testis    6.5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    31.175 Larval Midgut    3.6 Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    18.9 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    8.2 Adult Hindgut    8.2 Adult Malpighian Tubules    4.6 Adult Fat Body no informative data Adult Salivary Gland    6.3 Adult Heart    11.6 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    9.8 Adult Ovary    56 Adult Testis    6.5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    31.175 Larval Midgut    3.6 Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    18.9 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    8.2 Adult Hindgut    8.2 Adult Malpighian Tubules    4.6 Adult Fat Body no informative data Adult Salivary Gland    6.3 Adult Heart    11.6 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    9.8 Adult Ovary    56 Adult Testis    6.5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea     Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    no informative data   NA  Brain    no informative data   31.175  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    no informative data   3.6  Midgut    8.2   no informative data  Hindgut    8.2   no informative data  Malpighian Tubules    4.6   no informative data  Fat Body    no informative data   no informative data  Salivary Gland    6.3   NA  Heart    11.6   18.9  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    9.8   NA  Ovary    56   NA  Testis    6.5   NA  Male Accessory Gland    no informative data   no informative data  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004367 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4252-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage | maternal effect | recessive mei-4111-98 mei-4111-1325 mei-4112-1483 mei-4112-3616 mei-4112C-20 mei-4113-1272 mei-41D3 mei-41D18 lethal | embryonic stage | partially (with mei-41D5) mei-41RT1 lethal | embryonic stage | partially (with mei-41RT1) mei-41D5 lethal | embryonic stage | recessive mei-41D5 lethal | rescuable maternal effect mei-4111-1325 mei-4112-3616 mei-4112C-20 mei-4113-1272 mei-41D18 viable mei-4112-1483 mei-4112-3616 mei-4129D mei-4199B mei-41A1 mei-41A7 mei-41A8 mei-41A9 mei-41A10 mei-41A11 mei-41A12 mei-41A15 mei-41A22 mei-41A27 mei-41A28 mei-41A29 mei-41D1 mei-41D2 mei-41D3 mei-41D4 mei-41D5 mei-41D7 mei-41D8 mei-41D9 mei-41D10 mei-41D11 mei-41D12 mei-41D13 mei-41D14 mei-41D15 mei-41D19 mei-41RT1 mei-41RT2 viable, with Scer\GAL4pnr-MD237 mei-41GD4258 Sterility Allele female fertile mei-41D5 mei-41D9 mei-41D12 mei-41D13 mei-41D14 female fertile | reduced mei-411 mei-41D2 mei-41D5 female semi-sterile mei-4129D female semi-sterile | recessive mei-4113-1272 female sterile mei-41A8 mei-41D1 mei-41D2 mei-41D3 mei-41D4 mei-41D7 mei-41D8 mei-41D10 mei-41D11 mei-41D18 female sterile | heat sensitive mei-41RT1 mei-41RT2 female sterile | partially mei-4112-3616 mei-41A1 mei-41A7 mei-41A11 mei-41A12 mei-41A15 mei-41A16 mei-41A22 mei-41A27 mei-41A28 mei-41A29 mei-41D5 mei-41D9 mei-41D14 mei-41D15 mei-41D19 mei-41RT1 mei-41RT2 female sterile | partially | recessive mei-41A10 mei-41D6 mei-41D7 mei-41D8 mei-41D10 female sterile | recessive mei-4111-98 mei-4111-1325 mei-4112-1483 mei-4112-3616 mei-4112C-20 mei-41A1 mei-41A2 mei-41A3 mei-41A4 mei-41A5 mei-41A6 mei-41A7 mei-41A8 mei-41A9 mei-41A11 mei-41A12 mei-41A13 mei-41A14 mei-41A15 mei-41A16 mei-41A17 mei-41D3 mei-41D11 mei-41D18 mei-41D19 mei-41RT1 mei-41RT2 Other Phenotypes Allele chemical sensitive mei-4129D mei-41D5 mei-41D6 mei-41D7 mei-41D8 mei-41D9 mei-41D10 mei-41D11 mei-41D12 mei-41D14 mei-41D15 mei-41D18 mei-41D19 mei-41D20 mei-41D21 mei-41D22 mei-41RT1 mei-41RT2 mei-41unspecified chemical sensitive | dominant mei-41D3 chemical sensitive | larval stage | recessive mei-41AI chemical sensitive | recessive mei-41A10 mei-41D3 mei-41D5 mei-41RT1 mei-41RT2 mei-41RT2R1 mei-41RT2R2 chemical sensitive | semidominant mei-4129D mei-4199B mei-41A1 mei-41A2 mei-41A3 mei-41A4 mei-41A5 mei-41A6 mei-41A7 mei-41A8 mei-41A9 mei-41A10 mei-41A11 mei-41A12 mei-41A13 mei-41A14 mei-41A15 mei-41A16 mei-41A17 decreased cell death mei-4129D DNA repair defective mei-412 mei-4129D mei-41D5 mei-41D14 mei-41unspecified increased cell death mei-4129D meiotic cell cycle defective mei-412 mei-41A1 mei-41D2 mei-41D5 mei-41D6 mei-41D7 mei-41D8 mei-41D10 mitotic cell cycle defective mei-41D3 mitotic cell cycle defective | recessive mei-411 mei-412 radiation resistant mei-41D3 mei-41D5 radiation sensitive mei-4129D mei-41A1 mei-41A3 mei-41A4 mei-41A5 mei-41A6 mei-41A7 mei-41A8 mei-41A9 mei-41A10 mei-41A11 mei-41A12 mei-41A13 mei-41A14 mei-41A15 mei-41A16 mei-41A17 mei-41D5 mei-41RT1 mei-41unspecified radiation sensitive | recessive mei-41D5 mei-41RT1 wild-type mei-41+t10.5 Phenotype manifest in Allele blastoderm embryo | maternal effect mei-41D3 chromosome | larval stage mei-4129D cycle 13 embryo mei-41D3 cycle 14 embryo mei-41D3 egg | maternal effect mei-4111-1325 mei-4111-98 mei-4112-1483 mei-4112-3616 mei-4112C-20 mei-4113-1272 mei-41D18 mei-41D3 eye disc | conditional mei-4129D interphase of mitotic cell cycle | embryonic cycle 12 | maternal effect mei-41D3 interphase of mitotic cell cycle | embryonic cycle 13 | maternal effect mei-41D3 metaphase & condensed nuclear chromosome | conditional qualifier mei-4129D mitosis & nuclear chromosome mei-411 mei-412 morphogenetic furrow | conditional mei-4129D neuroblast | third instar larval stage mei-41D3 presumptive oocyte mei-41D3 spindle mei-41D3 wing disc mei-4129D
Classical Alleles ( 61 )
For All Classical Alleles Show
Allele of mei-41 Class Mutagen Stocks Known lesion mei-41D5 31 Yes mei-41D14 4 Yes mei-412 2 -- mei-41e02381 piggyBac transposase 2 -- mei-41G0221b P-element activity 2 -- mei-41RT1 PM hybrid dysgenesis P-element activity 2 Yes mei-41D12 1 Yes mei-41D1 1 -- mei-41D2 1 -- mei-41D3 1 Yes mei-41D9 ethyl methanesulfonate 1 Yes mei-41RT2 PM hybrid dysgenesis P-element activity 1 Yes mei-4111-1325 ethyl methanesulfonate 0 -- mei-4111-98 ethyl methanesulfonate 0 -- mei-4112-1483 ethyl methanesulfonate 0 -- mei-4112-3616 ethyl methanesulfonate 0 -- mei-4112C-20 ethyl methanesulfonate 0 -- mei-4113-1272 ethyl methanesulfonate 0 -- mei-411 0 -- mei-4129D P-element activity 0 Yes mei-4199B P-element activity 0 Yes mei-41A10 ethyl methanesulfonate 0 -- mei-41A11 ethyl methanesulfonate 0 -- mei-41A12 ethyl methanesulfonate 0 -- mei-41A13 ethyl methanesulfonate 0 -- mei-41A14 ethyl methanesulfonate 0 -- mei-41A15 ethyl methanesulfonate 0 -- mei-41A16 ethyl methanesulfonate 0 -- mei-41A17 ethyl methanesulfonate 0 -- mei-41A1 0 -- mei-41A22 0 -- mei-41A27 0 -- mei-41A28 0 -- mei-41A29 0 -- mei-41A2 ethyl methanesulfonate 0 -- mei-41A3 ethyl methanesulfonate 0 -- mei-41A4 ethyl methanesulfonate 0 -- mei-41A5 ethyl methanesulfonate 0 -- mei-41A6 ethyl methanesulfonate 0 -- mei-41A7 ethyl methanesulfonate 0 -- mei-41A8 ethyl methanesulfonate 0 -- mei-41A9 ethyl methanesulfonate 0 -- mei-41AI 0 -- mei-41D10 ethyl methanesulfonate 0 -- mei-41D11 ethyl methanesulfonate 0 -- mei-41D13 0 Yes mei-41D15 ethyl methanesulfonate 0 Yes mei-41D16 0 -- mei-41D18 ethyl methanesulfonate 0 -- mei-41D19 0 -- mei-41D20 ethyl methanesulfonate 0 -- mei-41D21 ethyl methanesulfonate 0 -- mei-41D22 ethyl methanesulfonate 0 -- mei-41D4 0 -- mei-41D6 ethyl methanesulfonate 0 -- mei-41D7 ethyl methanesulfonate 0 -- mei-41D8 ethyl methanesulfonate 0 -- mei-41RT1R1 P-element activity 0 Yes mei-41RT2R1 P-element activity 0 Yes mei-41RT2R2 P-element activity 0 Yes mei-41unspecified 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of mei-41 Class Mutagen Stocks Known lesion mei-41GD4258 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mei-41GL00284 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mei-41KK101792 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mei-41+t10.5 in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)78B (Laurencon et al., 2003) Df(1)BSC772 (Christensen et al., 2009.2.28) Df(1)l32 (Banga et al., 1995)
Duplicated in	Dp(1;2)r+75c (Mason et al., 1981, Eeken et al., 1985, Banga et al., 1995) Dp(1;2)v+75d (Mason et al., 1981) Dp(1;4)81l8g (Banga et al., 1995) Dp(1;4)r+l (Mason et al., 1981, Eeken et al., 1985)
Not disrupted in	Df(1)1D1 (Mason et al., 1981) Df(1)C52 (Mason et al., 1981) Df(1)C246 (Mason et al., 1981) Df(1)g (Mason et al., 1981) Df(1)HA85 (Mason et al., 1981) Df(1)HA92 (Mason et al., 1981) Df(1)HF349 (Mason et al., 1981) Df(1)JA26 (Mason et al., 1981) Df(1)KA6 (Mason et al., 1981) Df(1)KA9 (Mason et al., 1981) Df(1)N71 (Mason et al., 1981) Df(1)RA37 (Mason et al., 1981) Df(1)r-D1 (Eeken et al., 1985, Banga et al., 1995) Df(1)sd72b (Mason et al., 1981) Df(1)v-L15 (Mason et al., 1981)
Not duplicated in	Dp(1;3)f+71b (Mason et al., 1981, Eeken et al., 1985) Dp(1;4)80f18c (Banga et al., 1995) Dp(1;4)81h12b (Banga et al., 1995) Dp(1;4)81l12h (Banga et al., 1995) Dp(1;4)82c3k (Banga et al., 1995) Dp(1;4)exd81h24b (Banga et al., 1995) Dp(1;Y)v+y+ (Mason et al., 1981)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4258} NA P{KK101792} NA P{TRiP.GL00284} NA characterization construct P{mei-41+t10.5} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{5'3'}mei-4199B NA P{}mei-41RT1 NA P{}mei-41RT2 NA PBac{RB}mei-41e02381 NA insertion of enhancer trap P{lacW}mei-41G0221b No
Gene Ontology: Function, Process & Cellular Component ( 29 unique terms )
Terms Based on Experimental Evidence ( 14 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
actin filament organization inferred from mutant phenotype (Kiger et al., 2003) chromosome condensation inferred from genetic interaction with pr-set7 (Sakaguchi and Steward, 2007) DNA damage checkpoint inferred from mutant phenotype (Brodsky et al., 2000, LaRocque et al., 2007) DNA replication checkpoint inferred from mutant phenotype (Smolik and Jones, 2007) double-strand break repair via single-strand annealing inferred from mutant phenotype (LaRocque et al., 2007) double-strand break repair via synthesis-dependent strand annealing inferred from mutant phenotype (LaRocque et al., 2007) female meiosis chromosome segregation inferred from mutant phenotype (Baker and Carpenter, 1972) meiotic anaphase I inferred from mutant phenotype (McKim et al., 2000) mitotic cell cycle G2/M transition DNA damage checkpoint inferred from genetic interaction with nbs (Kondo and Perrimon, 2011) inferred from mutant phenotype (Kondo and Perrimon, 2011) reciprocal meiotic recombination inferred from mutant phenotype (McKim et al., 2000, Baker and Carpenter, 1972) regulation of cell shape inferred from mutant phenotype (Kiger et al., 2003) regulation of mitosis inferred from genetic interaction with dup AND inferred from mutant phenotype (Garner et al., 2001) response to DNA damage stimulus inferred from mutant phenotype (Ravi et al., 2009) telomere maintenance inferred from genetic interaction with nbs, tefu (Bi et al., 2005)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 16 terms )
Molecular Function
CV term Evidence References
binding inferred from electronic annotation with InterPro:IPR011990, InterPro:IPR016024 (FlyBase Curators et al., 2004-) kinase activity inferred from sequence or structural similarity (Mazzarelli, 2001.1.25) protein kinase activity non-traceable author statement (Morrison et al., 2000) protein serine/threonine kinase activity inferred from electronic annotation with InterPro:IPR012993 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
cell cycle checkpoint traceable author statement (Lee and Orr-Weaver, 2003) cellularization traceable author statement (Walworth, 2000) DNA damage checkpoint traceable author statement (Sekelsky et al., 2000) DNA repair traceable author statement (McKim et al., 2000) embryonic development via the syncytial blastoderm traceable author statement (Walworth, 2000, Lee and Orr-Weaver, 2003) imaginal disc development traceable author statement (Walworth, 2000) meiosis traceable author statement (Perrimon et al., 1986) mitotic cell cycle checkpoint traceable author statement (Walworth, 2000) oogenesis traceable author statement (Perrimon et al., 1986) phosphorylation non-traceable author statement (Morrison et al., 2000) regulation of syncytial blastoderm mitotic cell cycle traceable author statement (Brodsky et al., 2000) response to radiation traceable author statement (Walworth, 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions mei-41 allele Gene References mei-4129D DNApol-α180 (Brodsky et al., 2000) mei-41D1 okr (Ghabrial and Schupbach, 1999) spn-D (Abdu et al., 2003) mei-41D3 CycA (Sibon et al., 1999) CycB (Sibon et al., 1999) dup (Garner et al., 2001) grp (Sibon et al., 1999) mei-W68 (McKim et al., 2000) mus301 (Ghabrial and Schupbach, 1999, Masrouha et al., 2003) spn-B (Ghabrial and Schupbach, 1999, Masrouha et al., 2003) spn-D (Abdu et al., 2003) wee (Price et al., 2000) mei-41D5 CycA (Sibon et al., 1999) CycB (Sibon et al., 1999) grp (Sibon et al., 1999) rad201 (Sarantseva and Khromykh, 2001) mei-41D11 okr (Ghabrial and Schupbach, 1999) mei-41RT1 mus301 (Masrouha et al., 2003) spn-B (Ghabrial and Schupbach, 1999, Masrouha et al., 2003) mei-41unspecified CSN5 (Doronkin et al., 2002) spn-B (Ghabrial and Schupbach, 1999) spn-D (Abdu et al., 2003) tefu (Song et al., 2004) unspecified armi (Klattenhoff et al., 2007) aub (Klattenhoff et al., 2007) DNApol-α180 (LaRocque et al., 2007) mei-W68 (Ghabrial and Schupbach, 1999) nbs (Ciapponi et al., 2006) rad50 (Ciapponi et al., 2006) tefu (Ciapponi et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58948 DroID - A comprehensive database of gene and protein interactions. • FBgn0004367 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32608
Orthologs
Genome-wide drosophilid orthologs	Dana\GF12969 Dere\GG17962 Dmoj\GI18055 Dper\GL14921 Dsim\GD17284 Dvir\GJ22445 Dwil\GK21910 Dyak\GE17270
Curated drosophilid orthologs	Dsim\mei-41 (Anderson et al., 2009)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL010069-PA Aedes aegypti (mosquito) AGAP010313-PA Anopheles gambiae (mosquito) XP_001945871.1 Acyrthosiphon pisum (pea aphid) At5g40820.1 Arabidopsis thaliana (wall cress) 104468 Branchiostoma floridae (lancelet) XP_001896030.1 Brugia malayi (roundworm nematode) BGIBMGA007036-PA Bombyx mori (silk worm) ENSBTAP00000015321 Bos taurus (bovine) CAL0003061 Candida albicans (a form of yeast) ENSCAFP00000011639 Canis familiaris (dog) ENSCINP00000008576 Ciona intestinalis (sea squirt) CMN075C Cyanidioschyzon merolae (red alga) cn05312 Cryptococcus neoformans (yeast-like fungus) CPIJ002521 Culex pipens (mosquito) ENSCPOP00000006313 Cavia porcellus (guinea pig) 164972 Capitella spl (polychaete worm) DDB0229332 Dictyostelium discoideum (amoeba) 299627 Daphnia pulex (daphnia) ENSDARP00000080608 Danio rerio (zebra fish) ENSGACP00000014322 Gymnopilus aculeatus (mushroom) ENSGALP00000004185 Gallus gallus (chicken) ENSP00000343741 Homo sapiens (human) KLLA0C15785g Kluyveromyces lactis (yeast) 190706 Lottia gigantea (owl limpet) LmjF32.1460 Leishmania major (virus) ENSMODP00000026543 Monodelphis domestica (gray opossum) ENSMMUP00000010409 Macaca mulatta (rhesus monkey) ENSMUSP00000034980 Mus musculus (house mouse) XP_001601950.1 Nasonia vitripennis (wasp) ENSORLP00000015251 Oryzias latipes (japanese killifish) LOC_Os06g50910.1 Oryza sativa (asian rice) PHUM003446-PA Pediculus humanus (human body louse) 129584 Physcomitrella patens (moss) ENSPPYP00000015853 Pongo pygmaeus (orangutan) 818220 Populus trichocarpa (black cottonwood) ENSPTRP00000051017 Pan troglodytes (chimpanzee) 4865481 Sorghum bicolor (sorghum) YBR136W Saccharomyces cerevisiae (budding yeast) Smp_162340 Schistosoma mansoni (trematode parasite) SPBC216.05 Schizosaccharomyces pombe (fission yeast) XP_001181944.1 Strongylocentrotus purpuratus (purple sea urchin) XP_966827.1 Tribolium castaneum (red flour beetle) Tc00.1047053506223.120 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511719.10 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000022640 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000035418 Takifugu rubripes (pufferfish Takifugu) 97324.m00264 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000001341 Xenopus tropicalis (frog) YALI0F20636g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11218 NV11067 LH22730 ISCW019790 FBgn0234747 FBgn0223895 FBgn0209556 FBgn0196154 FBgn0188845 FBgn0168367 FBgn0168366 JGI_V11_299627 FBgn0247940 FBgn0246904 FBgn0152525 FBgn0140795 FBgn0130713 FBgn0121280 FBgn0110181 FBgn0090003 CPIJ002521 BGIBMGA007036 ACYPI005666 GB16077 AGAP010313 AAEL010069 PHUM003170 GLEAN_06311
Stocks & Reagents
Stocks Listed in FlyBase ( 52 )
Bloomington	6789 w1 mei-41D12 4169 mei-41RT1 f1/FM7a 18049 w1118 PBac{RB}mei-41e02381 4236 mei-41D5 f1; svspa-pol 35371 y1 sc* v1; P{TRiP.GL00284}attP2 4183 y1 mei-412/C(1)DX, y1 f1
Harvard	- PBac{RB}mei-41e02381
Kyoto	107611 mei-41RT1 f1/FM7a 101153 mei-41RT2 f1 / In(1)FM7 107617 y1 mei-412/C(1)DX, y1 f1
VDRC	v103624 P{KK101792}VIE-260B v11251 w1118; P{GD4258}v11251
	More stocks available...
Genomic Clones ( 2 )
	BACR13G13 BACR47D09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 1 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	EC055077
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004367 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32608
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	mei-41 mutants show defects in repair of double-strand breaks; they are defective in completing the later steps of homologous recombination repair, but show no defects in end-joining repair. (LaRocque et al., 2007) mei-41 is essential for cell cycle arrest at high doses of X-irradiation. (Oikemus et al., 2006) Mutants of mei-41 exhibit exacerbated p53-independent cell death. (Wichmann et al., 2006) S2 cells are treated with dsRNA made from templates generated with primers directed against this gene to assess effect on proteolysis of dup and geminin genes. (Higa et al., 2003) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 cells: change from round to spindle-shaped, with the formation of F-actin puncta and microtubule extensions. S2R+ cells are unaffected. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) The functions of mei-41 in ensuring fertility, cell cycle regulation and resistance to genotoxins are genetically separable. (Laurencon et al., 2003) mei-41 has a role in delaying entry into mitosis. (Garner et al., 2001) The DNA damage checkpoint is inactive in the developing eye in mei-41 mutants. (Brodsky et al., 2000) mei-41 is required for precocious anaphase in Drosophila females. (McKim et al., 2000) mei-41 has an essential checkpoint function at the midblastula transition. (Sibon et al., 1999) Gene is involved in post-replication recombination repair, post-replication translesion synthesis repair and pre-replication DNA repair of AA lesions. (de Buendia, 1998) The DNA-damaging activity of 6 phenazine and aminophenazine derivatives is assayed using the wing spot test in larvae, chemicals exhibit significant mutagenicity. (Watanabe et al., 1996) The mei-41 gene has been cloned and the sequences required for its function delimited using P element mediated transformation. (Banga et al., 1995) mei-41 is a member of a group of proteins with a P13K-like domain. mei-41 protein is required for DNA repair and for the ability of the cell to halt the mitotic cycle at one or more points in response to DNA damage. (Hari et al., 1995) DNA repair test is used to evaluate the genotoxic effect of griseofulvin in somatic larval cells. (Inoue et al., 1995) The mei-9/mei-41 DNA repair test has been used to assay the DNA-damaging potency of aflatoxin B1 and aflatoxin M1. (Shibahara et al., 1995) Genotoxic potency of aromatic amines and polycyclic aromatic hydrocarbons can be assayed using the DNA repair assay in mei-9a mei-41D5 transheterozygotes. (Fujikawa et al., 1993) mei-41 gene product inhibits mutagenesis at early stages of oogenesis. (Okladnova and Georgiev, 1992) The genotoxicity of a series of N-nitrosamines has been assayed using meiotic recombination deficient mei-9a; mei-41D5 larvae. (Negishi et al., 1991) An unusually high level of P-M hybrid dysgenesis is characteristic of hybrid offspring originating from Harwich P strain crosses. The phenotype is greatly exacerbated when males are deficient either in excision repair (mei-9 mutation) or in post-replication repair (mei-41 mutation). These findings demonstrate that both DNA repair pathways are essential for the repair of lesions induced by P-element transposition. (Margulies, 1990) mei-41 does not play the primary role in determining the frequency of P element excision or the variable nature of RpII2159 revertants. (Voelker et al., 1984) mei-41 alleles confer sensitivity to mutagens as a consequence of a defect in a caffeine-sensitive post-replication repair pathway (Boyd and Setlow, 1976; Boyd, Golino, Nguyen and Green, 1976; Boyd and Shaw, 1982). This defect in DNA repair is also manifested by a high frequency of mitotic chromosome breakage and instability (Baker, Carpenter and Ripoll, 1978; Gatti, 1979). mei-411 not hypermutable to alkylation nor defective in excision repair; yet mei-41D12 displays hypermutability to alkylation and defective alkylation excision repair (Smith and Dusenberry, 1988). Allelism based on lack of complementation (Mason et al., 1989). Most alleles of mei-41 also reduce female fertility and in some cases are female-sterile as homozygotes. Females homozygous for the more fertile alleles of mei-41 exhibit reduced levels of meiotic exchange. The observed reductions in exchange are not uniform, but rather are most extreme in distal regions. Chiasma interference is also diminished (Carpenter and Sandler, 1974; Baker and Hall, 1976). These reduced levels of exchange allow for high frequencies of meiotic loss and nondisjunction (see Baker and Hall, 1976). Ultrastructural analysis of pachytene in mei-41 and mei-412 females demonstrates a reduced number of late recombination nodules which are distributed in a fashion that parallels residual exchange events (Carpenter, 1979). Over half of those nodules which are observed are morphologically abnormal and are associated with unusual regions of relatively uncondensed chromatin. Stocks in which mei-41 is carried in the male are frequently observed to carry or acquire a bb mutation on the mei-41-bearing X chromosome (Hawley and Tartof, 1983). Several alleles of mei-41 have also been shown to inhibit rDNA magnification in the male germ-line (Hawley and Tartof, 1983; Hawley et al., 1985). Moreover, mei-41 males undergoing magnification also produce a high frequency of X-Y exchanges which result from one break within the X-chromosome rDNA cluster and the other at any of a large number of sites on the Y chromosome (Hawley and Tartof, 1983).
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078645 RefSeq (Proteins) • NP_523369 DDBJ / EMBL / GenBank • AAC46881 AAF48604 AAQ22732 AY282465 CZ480204 U34925 Z31938 Z31965 Entrez Gene - A searchable database of RefSeq genes. • 32608 UniProtKB/TrEMBL • Q9VXG8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Phosphatidylinositol 3/4-kinase, conserved site (IPR018936) Phosphatidylinositol 3-/4-kinase, catalytic (IPR000403) PIK-related kinase, FAT (IPR003151) PIK-related kinase, FATC (IPR003152) Protein kinase-like domain (IPR011009) UME (IPR012993) PIK-related kinase (IPR014009) Armadillo-type fold (IPR016024) Tetratricopeptide-like helical (IPR011990)
Linkouts
	BioGRID - A database of protein and genetic interactions • 58948 DroID - A comprehensive database of gene and protein interactions. • FBgn0004367 DRSC - Results from RNAi screens. • FBgn0004367 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004367 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4252-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004367 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32608 InParanoid A subset of ortholog calls from InParanoid. • AAEL010069-PA Aedes aegypti (mosquito) AGAP010313-PA Anopheles gambiae (mosquito) XP_001945871.1 Acyrthosiphon pisum (pea aphid) At5g40820.1 Arabidopsis thaliana (wall cress) 104468 Branchiostoma floridae (lancelet) XP_001896030.1 Brugia malayi (roundworm nematode) BGIBMGA007036-PA Bombyx mori (silk worm) ENSBTAP00000015321 Bos taurus (bovine) CAL0003061 Candida albicans (a form of yeast) ENSCAFP00000011639 Canis familiaris (dog) ENSCINP00000008576 Ciona intestinalis (sea squirt) CMN075C Cyanidioschyzon merolae (red alga) cn05312 Cryptococcus neoformans (yeast-like fungus) CPIJ002521 Culex pipens (mosquito) ENSCPOP00000006313 Cavia porcellus (guinea pig) 164972 Capitella spl (polychaete worm) DDB0229332 Dictyostelium discoideum (amoeba) 299627 Daphnia pulex (daphnia) ENSDARP00000080608 Danio rerio (zebra fish) ENSGACP00000014322 Gymnopilus aculeatus (mushroom) ENSGALP00000004185 Gallus gallus (chicken) ENSP00000343741 Homo sapiens (human) KLLA0C15785g Kluyveromyces lactis (yeast) 190706 Lottia gigantea (owl limpet) LmjF32.1460 Leishmania major (virus) ENSMODP00000026543 Monodelphis domestica (gray opossum) ENSMMUP00000010409 Macaca mulatta (rhesus monkey) ENSMUSP00000034980 Mus musculus (house mouse) XP_001601950.1 Nasonia vitripennis (wasp) ENSORLP00000015251 Oryzias latipes (japanese killifish) LOC_Os06g50910.1 Oryza sativa (asian rice) PHUM003446-PA Pediculus humanus (human body louse) 129584 Physcomitrella patens (moss) ENSPPYP00000015853 Pongo pygmaeus (orangutan) 818220 Populus trichocarpa (black cottonwood) ENSPTRP00000051017 Pan troglodytes (chimpanzee) 4865481 Sorghum bicolor (sorghum) YBR136W Saccharomyces cerevisiae (budding yeast) Smp_162340 Schistosoma mansoni (trematode parasite) SPBC216.05 Schizosaccharomyces pombe (fission yeast) XP_001181944.1 Strongylocentrotus purpuratus (purple sea urchin) XP_966827.1 Tribolium castaneum (red flour beetle) Tc00.1047053506223.120 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511719.10 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000022640 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000035418 Takifugu rubripes (pufferfish Takifugu) 97324.m00264 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000001341 Xenopus tropicalis (frog) YALI0F20636g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /newgene/mei-41-1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32608 modMine - Data generated by the modENCODE project. • FBgn0004367 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11218 NV11067 LH22730 ISCW019790 FBgn0234747 FBgn0223895 FBgn0209556 FBgn0196154 FBgn0188845 FBgn0168367 FBgn0168366 JGI_V11_299627 FBgn0247940 FBgn0246904 FBgn0152525 FBgn0140795 FBgn0130713 FBgn0121280 FBgn0110181 FBgn0090003 CPIJ002521 BGIBMGA007036 ACYPI005666 GB16077 AGAP010313 AAEL010069 PHUM003170 GLEAN_06311
Synonyms & Secondary IDs ( 26 )
Reported As
Symbol Synonym	4252 (Ravi et al., 2009) ATR (Schupbach et al., 2005, Higa et al., 2003, Bi et al., 2005, Garcia et al., 2007, Cenci et al., 2008, Katzenberger et al., 2006, Mehrotra et al., 2008, Komonyi et al., 2009, Peng and Karpen, 2009, Klattenhoff et al., 2009, Lu et al., 2010, Kondo and Perrimon, 2011) atr (Oikemus et al., 2006, Oikemus et al., 2006, Klovstad et al., 2008, Rong, 2008, Komonyi et al., 2009, Rong, 2008, Morciano et al., 2009) CG4252 (Song et al., 2004, Mazzarelli, 2001.1.25, Morrison et al., 2000, Keleman et al., 2009.8.5, Ni et al., 2011.7.19) DmATR (Johnson-Schlitz et al., 2007) Dmmei41 (Chen et al., 2006) fs(1)M37 (Perrimon et al., 1986, Mohler and Carroll, 1984, Mohler, 1977) mei-41 (Sakaguchi et al., 2008, Turner et al., 2008, Barbosa et al., 2007, McCaffrey et al., 2006, Gur-Arie and Abdu, 2007, Sakaguchi and Steward, 2007, Wichmann et al., 2006, Schupbach et al., 2006, McKim et al., 2000, Klattenhoff et al., 2007, LaRocque et al., 2007, Garcia et al., 2007, Nakayama et al., 2006, Busygina et al., 2004, Bi et al., 2005, Sakaguchi and Steward, 2007, LaRocque et al., 2007, Cenci et al., 2008, Brodsky et al., 2004, Baker and Carpenter, 1972, Barbosa et al., 2007, Trowbridge et al., 2007, Wei and Rong, 2007, Smolik and Jones, 2007, Klovstad et al., 2008, Pane et al., 2007, May et al., 2005, Chen et al., 2007, Purdy et al., 2005, Mehrotra et al., 2008, Abdu et al., 2007, Rickmyre et al., 2007, Titen and Golic, 2008, Rong, 2008, Joyce and McKim, 2009, Anderson et al., 2009, Christensen et al., 2009.2.28, Schauer et al., 2009, Komonyi et al., 2009, Peng and Karpen, 2009, Mattila et al., 2008, Peretz et al., 2009, Musarò et al., 2008, Klattenhoff et al., 2009, Blower et al., 2006, Morciano et al., 2009, Radcliffe et al., 2002, Benna et al., 2010, Silva et al., 2006, Kondo and Perrimon, 2011, Reis et al., 2011, Johnson-Schlitz et al., 2007, Koana et al., 2001, Mishra et al., 2011) mei41 (de Buendia et al., 2003, Cohen et al., 2003, Cohen et al., 2003, Flores and Engels, 1999, Ahmad and Golic, 1999, Sarantseva and Khromykh, 1999, Ghabrial and Schupbach, 1999, Weaver, 1998, de Buendia, 1998, Volkova and Omelyanchuk, 1997, Varentsova et al., 1997, Sarantseva and Khromykh, 1997, Keith and Schreiber, 1995, de Buendia, 1995, Smith et al., 1993, Ciapponi et al., 2006, Klovstad et al., 2008, Chen et al., 2007) Mei-41 (Superti-Furga, 1999, Eeken et al., 1985, Hochwagen, 2006, Nurminsky, 2007) MEI41 (Bassett et al., 1997) Mei-41/DATR (de Vries et al., 2005) MEI41/FRP1 (Morrison et al., 2000) mei-195   meiP41 (Huynh and St. Johnston, 2004) mus103 (de Buendia et al., 2003, de Buendia, 1998, de Buendia, 1995, Gamo et al., 1990, ) mus-103 (Gatti, 1979) mus104 (de Buendia et al., 2003, de Buendia, 1998, de Buendia, 1995, Omel'ianchuk et al., 1993, ) mus-104 (Todo and Ryo, 1992, Gatti, 1979) mus(1)103 (Olsen and Green, 1982, Mason et al., 1981) mus(1)104 (Vogel, 1992, Olsen and Green, 1982, Mason et al., 1981)
Name Synonym	ATM-RAD3 related (Katzenberger et al., 2006) Drosophila ATR (Wichmann et al., 2006) meiotic 41   Meiotic 41 (Rickmyre et al., 2007) meiotic-41 (Morciano et al., 2009)
Secondary FlyBase IDs
	FBgn0002708 FBgn0002880
References ( 250 )
Generate a list of	All references relating to this gene ( 250 )
List References by type	Research paper  ( 157 ) Supplementary material  ( 7 ) Review  ( 27 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 41 ) FlyBase analysis  ( 1 ) Conference report  ( 4 ) Computer file  ( 2 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 ) Stock list  ( 1 )
Recent research papers ( 7 )
	Chiolo et al., 2011, Cell 144(5): 732--744 Double-Strand Breaks in Heterochromatin Move Outside of a Dynamic HP1a Domain to Complete Recombinational Repair. [FBrf0213146] Kondo and Perrimon, 2011, Sci. Signal. 4(154): rs1 A Genome-Wide RNAi Screen Identifies Core Components of the G2-M DNA Damage Checkpoint. [FBrf0212700] Mishra et al., 2011, Mutat. Res. 722(1): 44--51 Tracing the tracks of genotoxicity by trivalent and hexavalent chromium in Drosophila melanogaster. [FBrf0213784] Moskalev et al., 2011, Biogerontology 12(3): 253--263 Radiation hormesis and radioadaptive response in Drosophila melanogaster flies with different genetic backgrounds: the role of cellular stress-resistance mechanisms. [FBrf0213740] Reis et al., 2011, PLoS ONE 6(3): e17512 Drosophila Genes That Affect Meiosis Duration Are among the Meiosis Related Genes That Are More Often Found Duplicated. [FBrf0213266] Benna et al., 2010, Curr. Biol. 20(4): 346--352 Drosophila timeless2 Is Required for Chromosome Stability and Circadian Photoreception. [FBrf0210091] Lu et al., 2010, Science 328(5983): 1278--1281 Meiotic recombination provokes functional activation of the p53 regulatory network. [FBrf0210965] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...