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General Information
Symbol
Dmel\mei-41
Species
D. melanogaster
Name
meiotic 41
Annotation Symbol
CG4252
Feature Type
FlyBase ID
FBgn0004367
Gene Model Status
Stock Availability
Gene Snapshot
meiotic 41 (mei-41) encodes a protein that, together with mus304, promotes DNA damage-dependent responses, including repair and cell cycle checkpoint signalling. [Date last reviewed: 2019-03-14]
Also Known As

mei41, ATR, mus103, mus104, mus(1)104

Key Links
Genomic Location
Cytogenetic map
Sequence location
X:16,391,698..16,399,850 [+]
Recombination map

1-53

RefSeq locus
NC_004354 REGION:16391698..16399850
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the PI3/PI4-kinase family. ATM subfamily. (Q9VXG8)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
-
Predictions / Assertions
Summaries
Gene Group (FlyBase)
ATYPICAL PROTEIN KINASES -
Atypical kinases are protein kinases or putative protein kinases that do not share clear sequence similarity with conventional eukaryotic protein kinases, but they or their orthologs have been shown experimentally to have protein kinase activity. Atypical kinases are defined in FBrf0201870.
Protein Function (UniProtKB)
Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence
(UniProt, Q9VXG8)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
mei-41 (R.S. Hawley)
mei-41 alleles confer sensitivity to mutagens as a consequence of a defect in a caffeine-sensitive post-replication repair pathway (Boyd and Setlow, 1976; Boyd et al., 1976; Boyd and Shaw, 1982). This defect in DNA repair is also manifested by a high frequency of mitotic chromosome breakage and instability (Baker et al., 1978; Gatti, 1979). mei-411 not hypermutable to alkylation nor defective in excision repair; yet mei-41D12 displays hypermutability to alkylation and defective alkylation excision repair (Smith and Dusenberry, 1988, Mechanisms and Consequences of DNA Damage Processing, Alan R. Liss, Inc., pp. 251-55). Allelism based on lack of complementation (Mason, Scobie, and Yamamoto, 1989, Mol. Gen. Genet. 215: 190-99). Most alleles of mei-41 also reduce female fertility and in some cases are female-sterile as homozygotes. Females homozygous for the more fertile alleles of mei-41 exhibit reduced levels of meiotic exchange. The observed reductions in exchange are not uniform, but rather are most extreme in distal regions. Chiasma interference is also diminished (Carpenter and Sandler, 1974; Baker and Hall, 1976). These reduced levels of exchange allow for high frequencies of meiotic loss and nondisjunction (see Baker and Hall, 1976). Ultrastructural analysis of pachytene in mei-41 and mei-412 females demonstrates a reduced number of late recombination nodules which are distributed in a fashion that parallels residual exchange events (Carpenter, 1979). Over half of those nodules which are observed are morphologically abnormal and are associated with unusual regions of relatively uncondensed chromatin. Stocks in which mei-41 is carried in the male are frequently observed to carry or acquire a bb mutation on the mei-41-bearing X chromosome (Hawley and Tartof, 1983). Several alleles of mei-41 have also been shown to inhibit rDNA magnification in the male germline (Hawley and Tartof, 1983; Hawley et al., 1985). Moreover, mei-41 males undergoing magnification also produce a high frequency of X-Y exchanges which result from one break within the X-chromosome rDNA cluster and the other at any of a large number of sites on the Y chromosome (Hawley and Tartof, 1983).
Summary (Interactive Fly)

ATM/ATR kinase, phosphatidylinositol 3-kinase - essential for the DNA damage checkpoint in larval imaginal discs and neuroblasts - required to delay mitosis in response to incomplete DNA replication in early nuclear divisions - monitors double-strand-break repair during meiotic crossing over - required for maintenance of intestinal stem cells in aging Drosophila

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\mei-41 or the JBrowse view of Dmel\mei-41 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0074271
7899
2517
Additional Transcript Data and Comments
Reported size (kB)

8.3 (northern blot)

Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0074047
289.3
2517
7.58
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with mus304.

(UniProt, Q9VXG8)
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mei-41 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (24 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN001673376
(assigned by GO_Central )
inferred from sequence or structural similarity with HGNC:882
Biological Process (22 terms)
Terms Based on Experimental Evidence (16 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:dup; FB:FBgn0000996
inferred from mutant phenotype
(assigned by UniProt )
inferred from genetic interaction with FLYBASE:MAGE; FB:FBgn0037481
Terms Based on Predictions or Assertions (9 terms)
CV Term
Evidence
References
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN001673376
(assigned by GO_Central )
traceable author statement
traceable author statement
traceable author statement
inferred from sequence or structural similarity with HGNC:882
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN001673376
(assigned by GO_Central )
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from sequence or structural similarity with HGNC:882
inferred from biological aspect of ancestor with PANTHER:PTN000124197
(assigned by GO_Central )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

mei-41 transcripts are detected in RNA from ovaries.

Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\mei-41 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 61 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of mei-41
Transgenic constructs containing regulatory region of mei-41
Deletions and Duplications ( 29 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
metaphase & condensed nuclear chromosome | conditional qualifier
mitosis & nuclear chromosome
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
11 of 15
Yes
Yes
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
11 of 15
Yes
Yes
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (2)
9 of 13
Yes
Yes
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (2)
5 of 12
Yes
Yes
1 of 12
No
Yes
Danio rerio (Zebrafish) (2)
9 of 15
Yes
Yes
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (2)
9 of 15
Yes
Yes
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (1)
8 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
12 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
10 of 12
Yes
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919004R )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500XC )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00QB )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00OX )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G013Q )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (4)
1 of 10
1 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 2 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 1 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Interactions Browser

Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Subunit Structure (UniProtKB)
Interacts with mus304.
(UniProt, Q9VXG8 )
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Metabolic Pathways
External Data
Linkouts
KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
Genomic Location and Detailed Mapping Data
Chromosome (arm)
X
Recombination map

1-53

Cytogenetic map
Sequence location
X:16,391,698..16,399,850 [+]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
14C3-14C3
Limits computationally determined from genome sequence between P{EP}EP1493EP1493 and P{EP}EP1547EP1547
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
14C-14C
(determined by in situ hybridisation)
14C4-14C6
(determined by in situ hybridisation)
Experimentally Determined Recombination Data
Left of (cM)
Notes

mei-41RT1 is located 0.04 map units to the right of mei-41D14 and 0.02 map units to the left of mei-41D9. mei-41RT2 is located 0.06 map units to the right of mei-41D14 and 0.03 map units to the right of mei-41D9.

mei-41D14 maps approximately 0.05 units to the left of mei-41D5.

Maps near 1-54.

Stocks and Reagents
Stocks (34)
Genomic Clones (9)
 

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (3)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences
BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
          Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            Antibody Information
            Laboratory Generated Antibodies
             
            Commercially Available Antibodies
             
            Other Information
            Relationship to Other Genes
            Source for database identify of
            Source for database merge of
            Additional comments
            Other Comments

            mei-41 is required for double strand break repair in the oocyte.

            mei-41 mutants show defects in repair of double-strand breaks; they are defective in completing the later steps of homologous recombination repair, but show no defects in end-joining repair.

            mei-41 is essential for cell cycle arrest at high doses of X-irradiation.

            Mutants of mei-41 exhibit exacerbated p53-independent cell death.

            S2 cells are treated with dsRNA made from templates generated with primers directed against this gene to assess effect on proteolysis of dup and geminin genes.

            dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

            RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 cells: change from round to spindle-shaped, with the formation of F-actin puncta and microtubule extensions. S2R+ cells are unaffected.

            The functions of mei-41 in ensuring fertility, cell cycle regulation and resistance to genotoxins are genetically separable.

            mei-41 has a role in delaying entry into mitosis.

            The DNA damage checkpoint is inactive in the developing eye in mei-41 mutants.

            mei-41 is required for precocious anaphase in Drosophila females.

            mei-41 has an essential checkpoint function at the midblastula transition.

            Gene is involved in post-replication recombination repair, post-replication translesion synthesis repair and pre-replication DNA repair of AA lesions.

            The DNA-damaging activity of 6 phenazine and aminophenazine derivatives is assayed using the wing spot test in larvae, chemicals exhibit significant mutagenicity.

            The mei-41 gene has been cloned and the sequences required for its function delimited using P element mediated transformation.

            mei-41 is a member of a group of proteins with a P13K-like domain. mei-41 protein is required for DNA repair and for the ability of the cell to halt the mitotic cycle at one or more points in response to DNA damage.

            DNA repair test is used to evaluate the genotoxic effect of griseofulvin in somatic larval cells.

            The mei-9/mei-41 DNA repair test has been used to assay the DNA-damaging potency of aflatoxin B1 and aflatoxin M1.

            Genotoxic potency of aromatic amines and polycyclic aromatic hydrocarbons can be assayed using the DNA repair assay in mei-9a mei-41D5 transheterozygotes.

            mei-41 gene product inhibits mutagenesis at early stages of oogenesis.

            The genotoxicity of a series of N-nitrosamines has been assayed using meiotic recombination deficient mei-9a; mei-41D5 larvae.

            An unusually high level of P-M hybrid dysgenesis is characteristic of hybrid offspring originating from Harwich P strain crosses. The phenotype is greatly exacerbated when males are deficient either in excision repair (mei-9 mutation) or in post-replication repair (mei-41 mutation). These findings demonstrate that both DNA repair pathways are essential for the repair of lesions induced by P-element transposition.

            mei-41 does not play the primary role in determining the frequency of P element excision or the variable nature of RpII2159 revertants.

            mei-41 alleles confer sensitivity to mutagens as a consequence of a defect in a caffeine-sensitive post-replication repair pathway (Boyd and Setlow, 1976; Boyd, Golino, Nguyen and Green, 1976; Boyd and Shaw, 1982). This defect in DNA repair is also manifested by a high frequency of mitotic chromosome breakage and instability (Baker, Carpenter and Ripoll, 1978; Gatti, 1979). mei-411 not hypermutable to alkylation nor defective in excision repair; yet mei-41D12 displays hypermutability to alkylation and defective alkylation excision repair (Smith and Dusenberry, 1988). Allelism based on lack of complementation (Mason et al., 1989). Most alleles of mei-41 also reduce female fertility and in some cases are female-sterile as homozygotes. Females homozygous for the more fertile alleles of mei-41 exhibit reduced levels of meiotic exchange. The observed reductions in exchange are not uniform, but rather are most extreme in distal regions. Chiasma interference is also diminished (Carpenter and Sandler, 1974; Baker and Hall, 1976). These reduced levels of exchange allow for high frequencies of meiotic loss and nondisjunction (see Baker and Hall, 1976). Ultrastructural analysis of pachytene in mei-41 and mei-412 females demonstrates a reduced number of late recombination nodules which are distributed in a fashion that parallels residual exchange events (Carpenter, 1979). Over half of those nodules which are observed are morphologically abnormal and are associated with unusual regions of relatively uncondensed chromatin. Stocks in which mei-41 is carried in the male are frequently observed to carry or acquire a bb mutation on the mei-41-bearing X chromosome (Hawley and Tartof, 1983). Several alleles of mei-41 have also been shown to inhibit rDNA magnification in the male germ-line (Hawley and Tartof, 1983; Hawley et al., 1985). Moreover, mei-41 males undergoing magnification also produce a high frequency of X-Y exchanges which result from one break within the X-chromosome rDNA cluster and the other at any of a large number of sites on the Y chromosome (Hawley and Tartof, 1983).

            Origin and Etymology
            Discoverer
            Etymology
            Identification
            External Crossreferences and Linkouts ( 41 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
            Other crossreferences
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            Flygut - An atlas of the Drosophila adult midgut
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            KEGG Genes - Molecular building blocks of life in the genomic space.
            modMine - A data warehouse for the modENCODE project
            SignaLink - A signaling pathway resource with multi-layered regulatory networks.
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            FLIGHT - Cell culture data for RNAi and other high-throughput technologies
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            FlyMine - An integrated database for Drosophila genomics
            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Synonyms and Secondary IDs (29)
            Reported As
            Symbol Synonym
            mei-195
            mei-41
            (Kermi et al., 2019, Khan et al., 2019, Meltzer et al., 2019, Merigliano et al., 2019, Murcia et al., 2019, Yasinskyi et al., 2019, Brady et al., 2018, Kang et al., 2018, Neitzel et al., 2018, Richardson and Portela, 2018, Bayona-Feliu et al., 2017, Merigliano et al., 2017, Flegel et al., 2016, Ma et al., 2016, Sarov et al., 2016, Yuan et al., 2016, Zheng et al., 2016, Blythe and Wieschaus, 2015, Fear et al., 2015, Mengoli et al., 2014, Mishra et al., 2014, Pushpavalli et al., 2014, Sopko et al., 2014, Li et al., 2013, Pushpavalli et al., 2013, Raffa et al., 2013, Bhadra et al., 2012, Lee et al., 2012, Nagel et al., 2012, Sakaguchi et al., 2012, Zhai et al., 2012, Joyce et al., 2011, Kondo and Perrimon, 2011, Kurzhals et al., 2011, Mishra et al., 2011, Reis et al., 2011, Zhou et al., 2011, Benna et al., 2010, Kong et al., 2010, Anderson et al., 2009, Christensen et al., 2009.2.28, Joyce and McKim, 2009, Klapholz et al., 2009, Klattenhoff et al., 2009, Komonyi et al., 2009, Morciano et al., 2009, Peng and Karpen, 2009, Peretz et al., 2009, Schauer et al., 2009, Cenci et al., 2008, Klovstad et al., 2008, Marek et al., 2008, Mattila et al., 2008, Mehrotra et al., 2008, Musarò et al., 2008, Rong, 2008, Sakaguchi et al., 2008, Titen and Golic, 2008, Turner et al., 2008, Abdu et al., 2007, Barbosa et al., 2007, Barbosa et al., 2007, Chen et al., 2007, Chmuzh et al., 2007, Garcia et al., 2007, Gur-Arie and Abdu, 2007, Johnson-Schlitz et al., 2007, Klattenhoff et al., 2007, LaRocque et al., 2007, LaRocque et al., 2007, Miranda-Saavedra and Barton, 2007, Pane et al., 2007, Rickmyre et al., 2007, Sakaguchi and Steward, 2007, Sakaguchi and Steward, 2007, Smolik and Jones, 2007, Trowbridge et al., 2007, Wei and Rong, 2007, Blower et al., 2006, McCaffrey et al., 2006, Moskalev et al., 2006, Nakayama et al., 2006, Schupbach et al., 2006, Silva et al., 2006, Wichmann et al., 2006, Bi et al., 2005, May et al., 2005, Purdy et al., 2005, Brodsky et al., 2004, Busygina et al., 2004, Radcliffe et al., 2002, Koana et al., 2001, McKim et al., 2000, Baker and Carpenter, 1972)
            mus-103
            Name Synonyms
            ATM-RAD3 related
            Ataxia Telangiectasia and Rad3 related
            meiotic 41
            Secondary FlyBase IDs
            • FBgn0002708
            • FBgn0002880
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            References (339)