receptor tyrosine phosphatase - required for embryonic and larval axon guidance - along with Ptp69D regulates segregation of the young axons into a single core bundle in the larval mushroom body - mutants are defective in long-term memory formation - Ptp10D-Ptp69D double mutants have a strong phenotype in which embryonic CNS axons abnormally cross the ventral midline
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.52
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ptp4E using the Feature Mapper tool.
Expression is observed in the mesoderm in gastrulating embryos. In germ band extended embryos, the strongest expression is seen in the posterior midgut. A scalloped pattern of expression is observed at the visceral mesoderm. At later stages, expression continues in the gut and is also observed in the central nervous system.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Ptp4E in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Ptp4E CG6899
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Spatial and temporal transcript accumulation pattern in ovaries is determined by in situ hybridisation.