FlyBase Gene Report: Dmel\Ptp4E

General Information

Symbol

Dmel\Ptp4E

Species

D. melanogaster

Name

Protein tyrosine phosphatase 4E

Annotation Symbol

CG6899

Feature Type

protein_coding_gene

FlyBase ID

FBgn0004368

Gene Model Status

Current

Stock Availability

35 publicly available

Enzyme Name (EC)

protein-tyrosine-phosphatase (3.1.3.48)

Gene Summary

Protein tyrosine phosphatase 4E (Ptp4E) encodes a transmembrane receptor tyrosine phosphatase closely related to the product of Ptp10D. Ptp4E single mutants have no known phenotypes. However, Ptp4E-Ptp10D double mutants have lethal respiratory defects. The product of Ptp4E regulates signaling through the receptor tyrosine kinases encoded by Egfr, btl and Pvr. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Gene Group
Interactive Fly

Also Known As

DPTP4E

Key Links

Genomic Location

Cytogenetic map

4D7-4D7

Sequence location

X:4,939,128..4,955,916 [+]

Recombination map

1-9

RefSeq locus

NC_004354 REGION:4939128..4955916

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (14 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables transmembrane receptor protein tyrosine phosphatase activity

inferred from direct assay

(Oon et al., 1993)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables protein tyrosine phosphatase activity

inferred from biological aspect of ancestor with PANTHER:PTN008567661

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with SGD:S000002389

(Gene Ontology Curators, 2002-)

inferred from electronic annotation with InterPro:IPR000242

(InterPro Project Members, 2004-)

Biological Process (9 terms)

Terms Based on Experimental Evidence (7 terms)

CV Term

Evidence

References

involved_in branching involved in open tracheal system development

inferred from mutant phenotype

(Jeon and Zinn, 2009)

involved_in central nervous system development

inferred from genetic interaction with FLYBASE:Ptp10D; FB:FBgn0004370

(Jeon et al., 2008)

involved_in motor neuron axon guidance

inferred from genetic interaction with FLYBASE:Ptp10D; FB:FBgn0004370,FLYBASE:Ptp69D; FB:FBgn0014007

(Jeon et al., 2008)

inferred from genetic interaction with FLYBASE:Ptp10D; FB:FBgn0004370,FLYBASE:Ptp52F; FB:FBgn0034085

(Jeon et al., 2008)

involved_in negative regulation of epidermal growth factor receptor signaling pathway

inferred from genetic interaction with FLYBASE:Ptp10D; FB:FBgn0004370

(Jeon et al., 2012)

inferred from genetic interaction with FLYBASE:Egfr; FB:FBgn0003731

(Jeon and Zinn, 2009)

involved_in negative regulation of fibroblast growth factor receptor signaling pathway

inferred from genetic interaction with FLYBASE:Ptp10D; FB:FBgn0004370

(Jeon et al., 2012)

involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway

inferred from genetic interaction with FLYBASE:Ptp10D; FB:FBgn0004370

(Jeon et al., 2012)

involved_in open tracheal system development

inferred from genetic interaction with FLYBASE:Ptp10D; FB:FBgn0004370

(Jeon et al., 2008)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in axon guidance

inferred from biological aspect of ancestor with PANTHER:PTN008567670

(GO Reference Genome Project, 2011-)

involved_in signal transduction

inferred from biological aspect of ancestor with PANTHER:PTN008567661

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

located_in apical plasma membrane

inferred from direct assay

(Jeon and Zinn, 2009)

located_in axon

inferred from direct assay

(Jeon et al., 2008)

located_in neuronal cell body

inferred from direct assay

(Jeon et al., 2008)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

RECEPTOR PROTEIN TYROSINE PHOSPHATASES

Pathway (FlyBase)

NEGATIVE REGULATORS OF EGFR SIGNALING PATHWAY

NEGATIVE REGULATORS OF FGFR SIGNALING PATHWAY

NEGATIVE REGULATORS OF PVR SIGNALING PATHWAY

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

protein tyrosine phosphatase activity

O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate (3.1.3.48)

RHEA 10684:

Summaries

Gene Snapshot

Gene Group (FlyBase)

RECEPTOR PROTEIN TYROSINE PHOSPHATASES -: Receptor Protein Tyrosine Phosphatases possess a single transmembrane domain and are localized to the plasma membrane. The Protein Tyrosine Phosphatases are defined by the active-site signature motif Cys-X5-Arg. (Adapted from FBrf0129980 and PMID:17057753).

Pathway (FlyBase)

NEGATIVE REGULATORS OF EGFR SIGNALING PATHWAY -: Negative regulators of Epidermal Growth Factor Receptor signaling down-regulate the pathway, suppressing the activation of ERK kinase (rl) or acting on downstream effectors.
NEGATIVE REGULATORS OF FGFR SIGNALING PATHWAY -: Negative regulators of Fibroblast Growth Factor Receptor signaling down-regulate the pathway, suppressing the activation of ERK kinase (rl) or acting on other effectors.
NEGATIVE REGULATORS OF PVR SIGNALING PATHWAY -: Negative regulators of Platelet-derived Growth Factor-Vascular Endothelial Growth Factor Receptor-related (Pvr) signaling down-regulate the pathway.

Summary (Interactive Fly)

receptor tyrosine phosphatase - required for embryonic and larval axon guidance - along with Ptp69D regulates segregation of the young axons into a single core bundle in the larval mushroom body - mutants are defective in long-term memory formation - Ptp10D-Ptp69D double mutants have a strong phenotype in which embryonic CNS axons abnormally cross the ventral midline

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Ptp4E for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9W4F5)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.52

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Ptp4E-RA

FBtr0070724

NM_080337

6568

1767

Ptp4E-RB

FBtr0070725

NM_167024

5480

1607

Ptp4E-RC

FBtr0301793

NM_001169198

6672

1767

Ptp4E-RD

FBtr0301794

NM_001169199

6590

1767

Ptp4E-RF

FBtr0301796

NM_001169201

6591

1767

Ptp4E-RG

FBtr0343528

NM_001169200

6060

1615

Ptp4E-RH

FBtr0343529

NM_001297946

6059

1761

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Ptp4E-PA

FBpp0070692

200.1

1767

5.33

FBpp0070693

182.3

1607

6.44

FBpp0291007

200.1

1767

5.33

FBpp0291008

200.1

1767

5.33

FBpp0291010

200.1

1767

5.33

FBpp0310132

183.1

1615

6.31

FBpp0310133

199.4

1761

5.30

X2JCK2

NP_001284875

AHN59346

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1767 aa isoforms: Ptp4E-PA, Ptp4E-PC, Ptp4E-PD, Ptp4E-PF

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ptp4E using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.68

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | faint | ubiquitous

(Fisher et al., 2012)

ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 7 -- 8

hindgut anlage

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

embryonic stage 8

mesoderm

(Jeon et al., 2008)

embryonic stage 9 -- 10

inclusive hindgut primordium

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

embryonic stage 11

visceral trunk mesoderm

(Jeon et al., 2008)

embryonic stage 11 -- 12

midline primordium

(Fisher et al., 2012)

larval ventral midline glial cell

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

tracheal primordium

(Fisher et al., 2012)

embryonic stage 11 -- 17

embryonic/larval posterior midgut

(Jeon et al., 2008)

embryonic stage 12 -- 16

embryonic/larval tracheal section

(Chung et al., 2011)

embryonic stage 13 -- 16

embryonic dorsal epidermis

(Fisher et al., 2012)

embryonic ventral epidermis

(Fisher et al., 2012)

larval muscle system

(Fisher et al., 2012)

larval visceral muscle cell

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 14

larval central nervous system

(Jeon et al., 2008)

embryonic stage 14 -- 17

embryonic/larval hindgut

(Jeon et al., 2008)

Additional Descriptive Data

Expression is observed in the mesoderm in gastrulating embryos. In germ band extended embryos, the strongest expression is seen in the posterior midgut. A scalloped pattern of expression is observed at the visceral mesoderm. At later stages, expression continues in the gut and is also observed in the central nervous system.

(Jeon et al., 2008)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in apical plasma membrane

inferred from direct assay

(Jeon and Zinn, 2009)

located_in axon

inferred from direct assay

(Jeon et al., 2008)

located_in neuronal cell body

inferred from direct assay

(Jeon et al., 2008)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Ptp4E in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Ptp4E

View exonic expression by tissue for Dmel\Ptp4E

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0004368

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31425/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0004368

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004368

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0004368

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6899

Flygut - An atlas of the Drosophila adult midgut

FBgn0004368

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Ptp4E

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 12 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Ptp4E

Transgenic constructs containing regulatory region of Ptp4E

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene partially disrupted in

Df(1)Ptp4E¹

(Jeon et al., 2008)

Gene disrupted in

Df(1)ovo4

(Jeon et al., 2008)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority die, with Scer\GAL4^pnr-MD237

Ptp4E^GD2609

viable

Ptp4E¹

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

Ptp4E^GD113

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Ptp4E^GD113

viable (with Df(1)ovo4)

Ptp4E¹

Sterility

Allele

female semi-sterile, with Scer\GAL4^{VP16.mat.αTub67C}

Ptp4E^HMS01838

fertile

Ptp4E¹

fertile (with Df(1)ovo4)

Ptp4E¹

Other Phenotypes

Allele

abnormal neuroanatomy | embryonic stage

Ptp4E^UAS.GFP

some die during pupal stage, with Scer\GAL4^pnr-MD237

Ptp4E^GD2609

Phenotype manifest in

Allele

larval ventral nerve cord, with Scer\GAL4^elav.PLu

Ptp4E^UAS.GFP

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (57)

Hsap\PTPRB

10 of 14

Yes

Hsap\PTPRJ

6 of 14

Yes

Hsap\PTPRH

5 of 14

Yes

Hsap\PTPRO

4 of 14

Yes

Hsap\PTPRK

2 of 14

Hsap\PTPRM

2 of 14

Hsap\PTPRQ

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\USH2A

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (44)

Rnor\Ptprb

9 of 14

Yes

Rnor\Ptprj

5 of 14

Yes

Rnor\Ptprh

4 of 14

Yes

Rnor\Ptpro

4 of 14

Yes

Rnor\Ptprv

4 of 14

Yes

Rnor\Ptprk

2 of 14

Rnor\Ptprm

2 of 14

Rnor\Ptprq

2 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (43)

Mmus\Ptprb

10 of 14

Yes

Mmus\Ptprj

6 of 14

Yes

Mmus\Ptprh

5 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

Yes

Mmus\Ptprt

2 of 14

Mmus\Ptprv

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (26)

Xtro\ptprb

6 of 13

Yes

Xtro\fn1

2 of 13

Yes

Xtro\LOC101734942

2 of 13

Yes

Xtro\ptprh

2 of 13

Yes

Xtro\ankle1

1 of 13

Xtro\cdc25c

1 of 13

Xtro\col12a1

1 of 13

Yes

Xtro\dcc

1 of 13

Xtro\LOC101733293

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\ptpro

1 of 13

Yes

Xtro\ptprq

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (61)

Drer\ptprb

9 of 14

Yes

Drer\ptprjb.1

5 of 14

Yes

Drer\ptprjb.2

5 of 14

Yes

Drer\ptprja

4 of 14

Yes

Drer\LOC569071

2 of 14

Yes

Drer\ptprh

2 of 14

Yes

Drer\ptprq

2 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\fn1b

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\ptpn18

1 of 14

Drer\ptpn20

1 of 14

Yes

Drer\ptpn21

1 of 14

Drer\ptpn22

1 of 14

Yes

Drer\ptpra

1 of 14

Drer\ptprbl

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (73)

Cele\dep-1

12 of 14

Yes

Cele\ptpn-22

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\Y22D7AR.7

1 of 14

Yes

Cele\Y39A3A.4

1 of 14

Cele\Y39B6A.30

1 of 14

Cele\Y48G1C.5

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (19)

Agam\AgaP_AGAP004246

7 of 12

Yes

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (1)

Atha\PTP1

4 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\PTP1

3 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\pyp3

4 of 12

Yes

Spom\pyp2

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Ptp4E. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (19)

Ptp10D

12 of 13

Ptp52F

6 of 13

Lar

5 of 13

5 of 13

5 of 13

4 of 13

4 of 13

3 of 13

3 of 13

csw

2 of 13

Pez

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

Eph

1 of 13

mop

1 of 13

sdk

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 3 )

Human Ortholog

Disease

Evidence

References

PTPRJ; protein tyrosine phosphatase receptor type J

model of colorectal cancer

IEA

(FlyBase, 2019-)

PTPRO; protein tyrosine phosphatase receptor type O

model of nephrotic syndrome type 6

IEA

(FlyBase, 2019-)

DCC; DCC netrin 1 receptor

model of colorectal cancer

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PTPRB; protein tyrosine phosphatase receptor type B

10 of 14

176882

PTPRJ; protein tyrosine phosphatase receptor type J

6 of 14

600925

colorectal cancer

PTPRH; protein tyrosine phosphatase receptor type H

5 of 14

602510

PTPRO; protein tyrosine phosphatase receptor type O

4 of 14

600579

NEPHROTIC SYNDROME, TYPE 6; NPHS6

nephrotic syndrome type 6

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Ptp10D|Ptp4E

suppressible

btl

(Jeon and Zinn, 2009)

Ptp10D|Ptp4E

enhanceable

btl

(Jeon and Zinn, 2009)

Ptp10D|Ptp4E

enhanceable

Egfr

(Jeon and Zinn, 2009)

Ptp10D|Ptp4E

suppressible

Egfr

(Jeon and Zinn, 2009)

Ptp10D|Ptp4E

suppressible

exp

(Iordanou et al., 2014)

Ptp4E

suppressible

Ptp10D

(Jeon et al., 2008)

Ptp10D|Ptp4E

enhanceable

Raf

(Jeon and Zinn, 2009)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

kon

suppressible

Ptp4E

(Harrison et al., 2021)

pbl

suppressible

Ptp4E

(Gregory et al., 2007)

Ptp52F

enhanceable

Ptp10D|Ptp4E

(Jeon et al., 2008)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

57939

DroID - A comprehensive database of gene and protein interactions.

FBgn0004368

MIST (protein-protein) - An integrated Molecular Interaction Database

31425

Pathways

Signaling Pathways (FlyBase)

NEGATIVE REGULATORS OF EGFR SIGNALING PATHWAY
NEGATIVE REGULATORS OF FGFR SIGNALING PATHWAY
NEGATIVE REGULATORS OF PVR SIGNALING PATHWAY

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Neutrophil degranulation

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-9

Cytogenetic map

4D7-4D7

Sequence location

X:4,939,128..4,955,916 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

4D7-4D7

Limits computationally determined from genome sequence between P{EP}EP425 and P{EP}CG3249^EP1400

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

4E1-4E2

(determined by in situ hybridisation)

(Oon et al., 1993)

4E-4E

(Yang et al., 1991)

Experimentally Determined Recombination Data

Location

1-9

(FlyBase, 2016)

1-9.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (35)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

42019

w^* Ptp4E¹

81915

w^*; PBac{U6:3-Ptp4E.gRNA}VK00027

13208

y¹ P{SUPor-P}Ptp4E^KG02328

60008

y¹ v¹; P{TRiP.HMS05000}attP40

81921

w^*; PBac{U6:3-Ptp4E-Ptp69D.gRNA}VK00027

44899

y¹ w^* Mi{MIC}Ptp4E^MI07920

Korea

10866

P{EP}Ptp4E^G1967

Kyoto

125694

w¹¹¹⁸ P{RS5}Ptp4E^5-HA-2826

VDRC

v1012

w¹¹¹⁸; P{GD113}v1012

v4297

w¹¹¹⁸ P{GD2609}v4297

v27232

w¹¹¹⁸ P{GD14479}v27232

v342833

P{hsFLP}1, y1 w1118; P{HD_CFD02119}attP40/CyO-GFP

More stocks available...

Genomic Clones (22)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (64)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

RT10263

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0004368

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0004368

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Jeon et al., 2008)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

The Hrp59 protein binds preferentially to a subset of mRNAs, including PtP4E mRNA.

(Kiesler et al., 2005)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Spatial and temporal transcript accumulation pattern in ovaries is determined by in situ hybridisation.

(Fitzpatrick et al., 1995)

Ptp4E has been cloned and sequenced, and its RNA expression pattern has been analysed.

(Oon et al., 1993)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Ptp4E CG6899

(Zhao, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

(Lee et al., 2013)

CG6899

(Chen et al., 2012, Ni et al., 2010.12.1, Perkins et al., 2009, Schiess et al., 2009, Legube et al., 2006, Brody et al., 2002, Morrison et al., 2000)

CT21187

(Hynes and Zhao, 2000)

DPTP4E

(Stoker and Dutta, 1998, Chien, 1996, Fitzpatrick et al., 1995, Oon et al., 1993)

PTP4E

(Kawakami et al., 2022, Andersen et al., 2004, Giot et al., 2003, Oon, 1993)

PtP4E

(Kiesler et al., 2005)

R-PTP 4E

(Morrison et al., 2000)

ptp4E

(Harrison et al., 2021, Dorogova et al., 2020)

Name Synonyms

Protein tyrosine phosphatase 4E

(Jeon and Zinn, 2015, Blard et al., 2007)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 73 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

31425

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9W4F5

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9W4F5

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0004368

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31425/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0004368

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0004368

FlyMine - An integrated database for Drosophila genomics

FBgn0004368

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG6899

MARRVEL_MODEL - MARRVEL (model organism gene)

31425

Linkouts

BioGRID - A database of protein and genetic interactions.

57939

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0004368

DroID - A comprehensive database of gene and protein interactions.

FBgn0004368

DRSC - Results frm RNAi screens

FBgn0004368

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004368

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0004368

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6899

Flygut - An atlas of the Drosophila adult midgut

FBgn0004368

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0004368

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

31425

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Neutrophil degranulation

References (90)

The following external sites may use different assemblies or annotations than FlyBase.

-0.68

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