FB2020_03, released Jun 16, 2020

Gene: Dmel\Ptp4E

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General Information
Symbol
Dmel\Ptp4E
Species
D. melanogaster
Name
Protein tyrosine phosphatase 4E
Annotation Symbol
CG6899
Feature Type
protein_coding_gene
FlyBase ID
FBgn0004368
Gene Model Status
Current
Stock Availability
29 publicly available
Enzyme Name (EC)
Protein-tyrosine-phosphatase (3.1.3.48)
Gene Snapshot
Protein tyrosine phosphatase 4E (Ptp4E) encodes a transmembrane receptor tyrosine phosphatase closely related to the product of Ptp10D. Ptp4E single mutants have no known phenotypes. However, Ptp4E-Ptp10D double mutants have lethal respiratory defects. The product of Ptp4E regulates signaling through the receptor tyrosine kinases encoded by Egfr, btl and Pvr. [Date last reviewed: 2019-03-14]
Other Summaries
Also Known As

DPTP4E

Key Links
Genomic Location
Cytogenetic map
4D7-4D7
Sequence location
X:4,939,128..4,955,916 [+]
Recombination map

1-9

RefSeq locus
NC_004354 REGION:4939128..4955916
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (12 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
protein tyrosine phosphatase activity
inferred from biological aspect of ancestor with PANTHER:PTN000439233
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with SGD:S000002389
(FlyBase Curators, 2008--)
Biological Process (8 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
branching involved in open tracheal system development
inferred from mutant phenotype
(Jeon and Zinn, 2009)
central nervous system development
inferred from genetic interaction with FLYBASE:Ptp10D; FB:FBgn0004370
(Jeon et al., 2008)
motor neuron axon guidance
inferred from genetic interaction with FLYBASE:Ptp10D; FB:FBgn0004370, FLYBASE:Ptp69D; FB:FBgn0014007
(Jeon et al., 2008)
inferred from genetic interaction with FLYBASE:Ptp10D; FB:FBgn0004370, FLYBASE:Ptp52F; FB:FBgn0034085
(Jeon et al., 2008)
negative regulation of epidermal growth factor receptor signaling pathway
inferred from genetic interaction with FLYBASE:Egfr; FB:FBgn0003731
(Jeon and Zinn, 2009)
inferred from genetic interaction with FLYBASE:Ptp10D; FB:FBgn0004370
(Jeon et al., 2012)
negative regulation of fibroblast growth factor receptor signaling pathway
inferred from genetic interaction with FLYBASE:Ptp10D; FB:FBgn0004370
(Jeon et al., 2012)
negative regulation of vascular endothelial growth factor receptor signaling pathway
inferred from genetic interaction with FLYBASE:Ptp10D; FB:FBgn0004370
(Jeon et al., 2012)
open tracheal system development
inferred from genetic interaction with FLYBASE:Ptp10D; FB:FBgn0004370
(Jeon et al., 2008)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
protein dephosphorylation
inferred from sequence or structural similarity with SGD:S000002389
(FlyBase Curators, 2008--)
inferred from biological aspect of ancestor with PANTHER:PTN000439233
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
apical plasma membrane
inferred from direct assay
(Jeon and Zinn, 2009)
axon
inferred from direct assay
(Jeon et al., 2008)
neuronal cell body
inferred from direct assay
(Jeon et al., 2008)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC)
Experimental Evidence
-
Predictions / Assertions
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate (3.1.3.48)
Summaries
Gene Group (FlyBase)
RECEPTOR PROTEIN TYROSINE PHOSPHATASES -
Receptor Protein Tyrosine Phosphatases possess a single transmembrane domain and are localized to the plasma membrane. The Protein Tyrosine Phosphatases are defined by the active-site signature motif Cys-X5-Arg. (Adapted from FBrf0129980 and PMID:17057753).
Pathway (FlyBase)
Negative Regulators of EGFR Signaling Pathway -
Negative regulators of Epidermal Growth Factor Receptor signaling down-regulate the pathway, suppressing the activation of ERK kinase (rl) or acting on downstream effectors.
Negative Regulators of Pvr Signaling Pathway -
Negative regulators of Platelet-derived Growth Factor-Vascular Endothelial Growth Factor Receptor-related (Pvr) signaling down-regulate the pathway.
Negative Regulators of FGFR Signaling Pathway -
Negative regulators of Fibroblast Growth Factor Receptor signaling down-regulate the pathway, suppressing the activation of ERK kinase (rl) or acting on other effectors.
Summary (Interactive Fly)

receptor tyrosine phosphatase - required for embryonic and larval axon guidance - along with Ptp69D regulates segregation of the young axons into a single core bundle in the larval mushroom body - mutants are defective in long-term memory formation - Ptp10D-Ptp69D double mutants have a strong phenotype in which embryonic CNS axons abnormally cross the ventral midline

Gene Model and Products
Number of Transcripts
7
Number of Unique Polypeptides
4

Please see the GBrowse view of Dmel\Ptp4E or the JBrowse view of Dmel\Ptp4E for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Ptp4E-RA
FBtr0070724
NM_080337
6568
1767
Ptp4E-RB
FBtr0070725
NM_167024
5480
1607
Ptp4E-RC
FBtr0301793
NM_001169198
6672
1767
Ptp4E-RD
FBtr0301794
NM_001169199
6590
1767
Ptp4E-RF
FBtr0301796
NM_001169201
6591
1767
Ptp4E-RG
FBtr0343528
NM_001169200
6060
1615
Ptp4E-RH
FBtr0343529
NM_001297946
6059
1761
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Ptp4E-PA
FBpp0070692
200.1
1767
5.33
NP_525076
AAF45998
Ptp4E-PB
FBpp0070693
182.3
1607
6.44
NP_726967
AAN09133
Ptp4E-PC
FBpp0291007
200.1
1767
5.33
NP_001162669
ACZ95206
Ptp4E-PD
FBpp0291008
200.1
1767
5.33
NP_001162670
ACZ95207
Ptp4E-PF
FBpp0291010
200.1
1767
5.33
NP_001162672
ACZ95209
Ptp4E-PG
FBpp0310132
183.1
1615
6.31
NP_001162671
ACZ95208
Ptp4E-PH
FBpp0310133
199.4
1761
5.30
NP_001284875
AHN59346
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1767 aa isoforms: Ptp4E-PA, Ptp4E-PC, Ptp4E-PD, Ptp4E-PF
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ptp4E using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | faint | ubiquitous
(Fisher et al., 2012)
ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 7 -- 8
hindgut anlage
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
inclusive hindgut primordium
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
midline primordium
(Fisher et al., 2012)
midline ventral glial cell
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
tracheal primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
embryonic/larval muscle system
(Fisher et al., 2012)
embryonic/larval visceral muscle
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 8
mesoderm
(Jeon et al., 2008)
embryonic stage 11 -- 17
embryonic/larval posterior midgut
(Jeon et al., 2008)
embryonic stage 11
visceral mesoderm
(Jeon et al., 2008)
embryonic stage 14
embryonic/larval central nervous system
(Jeon et al., 2008)
embryonic stage 14 -- 17
embryonic/larval hindgut
(Jeon et al., 2008)
embryonic stage 12 -- 16
embryonic/larval trachea
(Chung et al., 2011)
Additional Descriptive Data

Expression is observed in the mesoderm in gastrulating embryos. In germ band extended embryos, the strongest expression is seen in the posterior midgut. A scalloped pattern of expression is observed at the visceral mesoderm. At later stages, expression continues in the gut and is also observed in the central nervous system.

(Jeon et al., 2008)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
apical plasma membrane
inferred from direct assay
(Jeon and Zinn, 2009)
axon
inferred from direct assay
(Jeon et al., 2008)
neuronal cell body
inferred from direct assay
(Jeon et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Ptp4E in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 10 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Ptp4E
Transgenic constructs containing regulatory region of Ptp4E
Deletions and Duplications ( 2 )
Partially disrupted in
Df(1)Ptp4E1
(Jeon et al., 2008)
Disrupted in
Df(1)ovo4
(Jeon et al., 2008)
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (12)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\PTPRB
12 of 15
Yes
Yes
Hsap\PTPRJ
6 of 15
No
Yes
Hsap\PTPRH
5 of 15
No
Yes
Hsap\PTPRO
4 of 15
No
Yes
1  
Hsap\PTPRQ
2 of 15
No
Yes
Hsap\COL20A1
1 of 15
No
Yes
Hsap\PTPN7
1 of 15
No
No
Hsap\PTPRD
1 of 15
No
No
Hsap\PTPRF
1 of 15
No
No
Hsap\PTPRS
1 of 15
No
No
Hsap\PTPRZ1
1 of 15
No
No
Hsap\TNXB
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (11)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Ptprb
12 of 15
Yes
Yes
Mmus\Ptprj
6 of 15
No
Yes
Mmus\Ptprh
5 of 15
No
Yes
Mmus\Ptpro
5 of 15
No
Yes
Mmus\Col20a1
1 of 15
No
Yes
Mmus\Ptprd
1 of 15
No
No
Mmus\Ptprf
1 of 15
No
No
Mmus\Ptprq
1 of 15
No
No
Mmus\Ptprs
1 of 15
No
No
Mmus\Ptprv
1 of 15
No
Yes
Mmus\Ptprz1
1 of 15
No
No
Rattus norvegicus (Norway rat) (7)
Rnor\Ptprb
4 of 13
Yes
Yes
Rnor\Ptpro
4 of 13
Yes
Yes
Rnor\Ptprv
4 of 13
Yes
Yes
Rnor\Ptprh
3 of 13
No
Yes
Rnor\Ptprj
3 of 13
No
Yes
Rnor\Col20a1
1 of 13
No
Yes
Rnor\Ptprq
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (9)
Xtro\ptprb
6 of 12
Yes
Yes
Xtro\ptpro
4 of 12
No
Yes
Xtro\ptprh
3 of 12
No
Yes
Xtro\ptprq
3 of 12
No
Yes
Xtro\LOC100493594
2 of 12
No
Yes
Xtro\LOC105945771
2 of 12
No
Yes
Xtro\col14a1
1 of 12
No
Yes
Xtro\igdcc4
1 of 12
No
No
Xtro\LOC101733293
1 of 12
No
Yes
Danio rerio (Zebrafish) (15)
Drer\ptprb
10 of 15
Yes
Yes
Drer\ptprja
6 of 15
No
Yes
Drer\ptpro
5 of 15
No
Yes
Drer\ptprh
4 of 15
No
Yes
Drer\LOC569071
3 of 15
No
Yes
Drer\ptprjb.1
3 of 15
No
Yes
Drer\ptprjb.2
3 of 15
No
Yes
Drer\ptprq
2 of 15
No
Yes
Drer\col7a1l
1 of 15
No
Yes
Drer\LOC101885876
1 of 15
No
Yes
Drer\ptpn22
1 of 15
No
Yes
Drer\ptprbl
1 of 15
No
Yes
Drer\ptprfb
1 of 15
No
No
Drer\ptprz1b
1 of 15
No
No
Drer\slc35c2
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (15)
Cele\dep-1
13 of 15
Yes
Yes
Cele\C18E9.7
1 of 15
No
Yes
Cele\C33F10.8
1 of 15
No
No
Cele\egg-4
1 of 15
No
No
Cele\egg-5
1 of 15
No
No
Cele\F35C11.2
1 of 15
No
No
Cele\M04G7.2
1 of 15
No
No
Cele\M05D6.3
1 of 15
No
No
Cele\ptp-3
1 of 15
No
No
Cele\T13H5.1
1 of 15
No
No
Cele\Y39A3A.4
1 of 15
No
No
Cele\Y41D4A.5
1 of 15
No
No
Cele\Y48G9A.9
1 of 15
No
No
Cele\ZK354.8
1 of 15
No
No
Cele\ZK616.65
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (1)
Atha\PTP1
3 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\PTP1
3 of 15
Yes
No
Scer\PTP2
1 of 15
No
No
Scer\PTP3
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (3)
Spom\pyp2
2 of 12
Yes
Yes
Spom\pyp3
2 of 12
Yes
No
Spom\pyp1
1 of 12
No
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091900MG )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00005393
Drosophila simulans
Dsim\GD16715
Drosophila sechellia
Dsec\GM12377
Drosophila erecta
Dere\GG18737
Drosophila yakuba
Dyak\GE16377
Drosophila ananassae
Dana\GF20352
Drosophila pseudoobscura pseudoobscura
Dpse\GA19940
Drosophila persimilis
Dper\GL15029
Drosophila willistoni
Dwil\GK19778
Drosophila virilis
Dvir\GJ15786
Drosophila mojavensis
Dmoj\GI21662
Drosophila grimshawi
Dgri\GH24682
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500DW )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17016134
Glossina morsitans
Tsetse fly
Gmor\GMOY009213
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_13816
Mayetiola destructor
Hessian fly
Mdes\Mdes005175
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL012083
Anopheles darlingi
American malaria mosquito
Adar\ADAC004290
Anopheles gambiae
Malaria mosquito
Agam\GPXH1
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ006052
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00EY )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA001078
Bombyx mori
Silkmoth
Bmor\BGIBMGA001079
Danaus plexippus
Monarch butterfly
Dple\DPOGS215963-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL005888
Apis florea
Little honeybee
Aflo\2147485553
Apis mellifera
Western honey bee
Amel\GB45612
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP10281
Bombus terrestris
Buff-tailed bumblebee
Bter\15212938
Linepithema humile
Argentine ant
Lhum\LH11081
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00075c
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG009079
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03484
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_07672
Pediculus humanus
Human body louse
Phum\PHUM530510
Rhodnius prolixus
Kissing bug
Rpro\RPRC000896
Rhodnius prolixus
Kissing bug
Rpro\RPRC012423
Cimex lectularius
Bed bug
Clec\CLEC002490-PC
Cimex lectularius
Bed bug
Clec\CLEC002490-PB
Cimex lectularius
Bed bug
Clec\CLEC002490
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006943
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_04740
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00DY )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR011033
Ixodes scapularis
Black-legged tick
Isca\ISCW022067
Stegodyphus mimosarum
African social velvet spider
Smim\KFM77963.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM71044.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g04890
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_306015
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G00JF )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-R/Ptp/B
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Fn3f_8
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Fn3_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Fn3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Fn3_16
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Fn3_22
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hhat
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-PtprbL
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_011327gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-PtprB
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Fn3_17
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ptpd
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Fn3_8
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Fn3_32
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Fn3_29
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr/Ptpc1
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000014059
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000003151
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000004644
Gallus gallus
Domestic chicken
Ggal\PTPRB
Gallus gallus
Domestic chicken
Ggal\PTPRJ
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000000584
Gallus gallus
Domestic chicken
Ggal\PTPRO
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (14)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Ptp10D
8 of 10
Ptp52F
4 of 10
Lar
3 of 10
Ptp36E
2 of 10
Ptp69D
2 of 10
PTP-ER
2 of 10
Ptpmeg2
2 of 10
CG42327
1 of 10
csw
1 of 10
IA-2
1 of 10
Pez
1 of 10
Ptp61F
1 of 10
Ptp99A
1 of 10
Ptpmeg
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 2 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    PTPRB; protein tyrosine phosphatase receptor type B
    12 of 15
    176882
        PTPRJ; protein tyrosine phosphatase receptor type J
        6 of 15
        600925
        PTPRH; protein tyrosine phosphatase receptor type H
        5 of 15
        602510
            PTPRO; protein tyrosine phosphatase receptor type O
            4 of 15
            600579
             
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Interactions Browser
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Ptp10D|Ptp4E
            suppressible
            btl
            (Jeon and Zinn, 2009)
            Ptp4E|Ptp10D
            enhanceable
            btl
            (Jeon and Zinn, 2009)
            Ptp10D|Ptp4E
            suppressible
            Egfr
            (Jeon and Zinn, 2009)
            Ptp10D|Ptp4E
            enhanceable
            Egfr
            (Jeon and Zinn, 2009)
            Ptp10D|Ptp4E
            suppressible
            exp
            (Iordanou et al., 2014)
            Ptp4E
            suppressible
            Ptp10D
            (Jeon et al., 2008)
            Ptp4E|Ptp10D
            enhanceable
            Raf
            (Jeon and Zinn, 2009)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            pbl
            suppressible
            Ptp4E
            (Gregory et al., 2007)
            Ptp52F
            enhanceable
            Ptp10D|Ptp4E
            (Jeon et al., 2008)
            External Data
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Negative Regulators of EGFR Signaling Pathway -
            Negative regulators of Epidermal Growth Factor Receptor signaling down-regulate the pathway, suppressing the activation of ERK kinase (rl) or acting on downstream effectors.
            Negative Regulators of Pvr Signaling Pathway -
            Negative regulators of Platelet-derived Growth Factor-Vascular Endothelial Growth Factor Receptor-related (Pvr) signaling down-regulate the pathway.
            Negative Regulators of FGFR Signaling Pathway -
            Negative regulators of Fibroblast Growth Factor Receptor signaling down-regulate the pathway, suppressing the activation of ERK kinase (rl) or acting on other effectors.
            Metabolic Pathways
            External Data
            Linkouts
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            X
            Recombination map

            1-9

            Cytogenetic map
            4D7-4D7
            Sequence location
            X:4,939,128..4,955,916 [+]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            4D7-4D7
            Limits computationally determined from genome sequence between P{EP}EP425 and P{EP}CG3249EP1400
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            4E1-4E2
            (determined by in situ hybridisation)
            (Oon et al., 1993)
            4E-4E
            (Yang et al., 1991)
            Experimentally Determined Recombination Data
            Location

            1-9

            (FlyBase, 2016)

            1-9.7

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (29)
            Genomic Clones (22)
            cDNA Clones (73)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            Antibody Information
            Laboratory Generated Antibodies
             

            polyclonal

            (Jeon et al., 2008)
            Commercially Available Antibodies
             
            Other Information
            Relationship to Other Genes
            Source for database identify of

            Source for identity of: Ptp4E CG6899

            (Zhao, 1999.11)
            Source for database merge of
            Additional comments
            Other Comments

            The Hrp59 protein binds preferentially to a subset of mRNAs, including PtP4E mRNA.

            (Kiesler et al., 2005)

            dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

            (Kiger et al., 2003)

            Spatial and temporal transcript accumulation pattern in ovaries is determined by in situ hybridisation.

            (Fitzpatrick et al., 1995)

            Ptp4E has been cloned and sequenced, and its RNA expression pattern has been analysed.

            (Oon et al., 1993)
            Origin and Etymology
            Discoverer
            Etymology
            Identification
            External Crossreferences and Linkouts ( 68 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            modMine - A data warehouse for the modENCODE project
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            FLIGHT - Cell culture data for RNAi and other high-throughput technologies
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            FlyMine - An integrated database for Drosophila genomics
            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Synonyms and Secondary IDs (9)
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            References (74)