FlyBase Gene Report: Dmel\Ptp10D

General Information

Symbol

Dmel\Ptp10D

Species

D. melanogaster

Name

Protein tyrosine phosphatase 10D

Annotation Symbol

CG1817

Feature Type

protein_coding_gene

FlyBase ID

FBgn0004370

Gene Model Status

Current

Stock Availability

21 publicly available

Gene Snapshot

Protein tyrosine phosphatase 10D (Ptp10D) encodes a transmembrane receptor tyrosine phosphatase closely related to the product of Ptp4E. Ptp4E-Ptp10D double mutants have lethal respiratory defects. Ptp10D-Ptp69D double mutants have a strong phenotype in which embryonic CNS axons abnormally cross the ventral midline. The product of Ptp10D regulates signaling through the receptor tyrosine kinases encoded by Egfr, btl and Pvr. It also binds to the product of sas to regulate its signaling in glia. [Date last reviewed: 2019-03-14]

Other Summaries

Alliance
Auto summary
Pathway
Gene Group
UniProtKB
Interactive Fly

Also Known As

DPTP10D

Key Links

Genomic Location

Cytogenetic map

10D1-10D4

Sequence location

X:11,622,015..11,677,338 [+]

Recombination map

1-35

RefSeq locus

NC_004354 REGION:11622015..11677338

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (14 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables transmembrane receptor protein tyrosine phosphatase activity

inferred from direct assay

(Muda et al., 2002, Tian and Zinn, 1994)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables protein tyrosine phosphatase activity

inferred from biological aspect of ancestor with PANTHER:PTN000439233

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (10 terms)

Terms Based on Experimental Evidence (10 terms)

CV Term

Evidence

References

involved_in axon guidance

inferred from genetic interaction with FLYBASE:sas; FB:FBgn0002306

(Lee et al., 2013)

inferred from genetic interaction with FLYBASE:Ptp69D; FB:FBgn0014007

(Lee et al., 2013)

inferred from physical interaction with FLYBASE:sas; FB:FBgn0002306

(Lee et al., 2013)

involved_in branching involved in open tracheal system development

inferred from mutant phenotype

(Jeon and Zinn, 2009)

involved_in central nervous system development

inferred from genetic interaction with FLYBASE:Ptp4E; FB:FBgn0004368

(Jeon et al., 2008)

involved_in long-term memory

inferred from mutant phenotype

(Qian et al., 2007)

involved_in motor neuron axon guidance

inferred from genetic interaction with FLYBASE:Ptp4E; FB:FBgn0004368, FLYBASE:Ptp69D; FB:FBgn0014007

(Jeon et al., 2008)

inferred from genetic interaction with FLYBASE:Ptp4E; FB:FBgn0004368, FLYBASE:Ptp52F; FB:FBgn0034085

(Jeon et al., 2008)

inferred from genetic interaction with FLYBASE:Lar; FB:FBgn0000464

(Sun et al., 2001)

inferred from genetic interaction with FLYBASE:Lar; FB:FBgn0000464, FLYBASE:Ptp99A; FB:FBgn0004369

(Sun et al., 2001)

inferred from genetic interaction with FLYBASE:Ptp69D; FB:FBgn0014007

(Sun et al., 2001)

involved_in negative regulation of epidermal growth factor receptor signaling pathway

inferred from genetic interaction with FLYBASE:Egfr; FB:FBgn0003731

(Jeon and Zinn, 2009)

inferred from genetic interaction with FLYBASE:Ptp4E; FB:FBgn0004368

(Jeon et al., 2012)

involved_in negative regulation of fibroblast growth factor receptor signaling pathway

inferred from genetic interaction with FLYBASE:Ptp4E; FB:FBgn0004368

(Jeon et al., 2012)

involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway

inferred from genetic interaction with FLYBASE:Ptp4E; FB:FBgn0004368

(Jeon et al., 2012)

involved_in open tracheal system development

inferred from genetic interaction with FLYBASE:Ptp4E; FB:FBgn0004368

(Jeon et al., 2008)

involved_in protein dephosphorylation

inferred from direct assay

(Muda et al., 2002, Tian and Zinn, 1994)

inferred from mutant phenotype

(Muda et al., 2002)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in protein dephosphorylation

inferred from biological aspect of ancestor with PANTHER:PTN000439233

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in apical part of cell

inferred from direct assay

(Jeon and Zinn, 2009)

located_in axon

inferred from direct assay

(Jeon et al., 2008)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

RECEPTOR PROTEIN TYROSINE PHOSPHATASES

Pathway (FlyBase)

Negative Regulators of EGFR Signaling Pathway

Negative Regulators of Pvr Signaling Pathway

Negative Regulators of FGFR Signaling Pathway

Protein Family (UniProt)

Belongs to the protein-tyrosine phosphatase family. Receptor class subfamily. (P35992)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

RECEPTOR PROTEIN TYROSINE PHOSPHATASES -: Receptor Protein Tyrosine Phosphatases possess a single transmembrane domain and are localized to the plasma membrane. The Protein Tyrosine Phosphatases are defined by the active-site signature motif Cys-X5-Arg. (Adapted from FBrf0129980 and PMID:17057753).

Pathway (FlyBase)

Negative Regulators of EGFR Signaling Pathway -: Negative regulators of Epidermal Growth Factor Receptor signaling down-regulate the pathway, suppressing the activation of ERK kinase (rl) or acting on downstream effectors.
Negative Regulators of Pvr Signaling Pathway -: Negative regulators of Platelet-derived Growth Factor-Vascular Endothelial Growth Factor Receptor-related (Pvr) signaling down-regulate the pathway.
Negative Regulators of FGFR Signaling Pathway -: Negative regulators of Fibroblast Growth Factor Receptor signaling down-regulate the pathway, suppressing the activation of ERK kinase (rl) or acting on other effectors.

Protein Function (UniProtKB)

May have a role in axon outgrowth and guidance.

(UniProt, P35992)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Ptp10D for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Stop-codon suppression (UGA) postulated; FBrf0216884.

Transposon inserted in intron

gene_with_stop_codon_read_through ; SO:0000697

Gene model reviewed during 5.44

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.46

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Sequence Ontology: Class of Gene

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Ptp10D-RB

FBtr0073522

NM_167292

7308

1631

Ptp10D-RE

FBtr0273235

NM_001144715

7269

1558

Ptp10D-RF

FBtr0330392

NM_206690

7385

1990

Ptp10D-RG

FBtr0330393

NM_206691

8642

1990

Ptp10D-RH

FBtr0330394

NM_001272524

8335

1653

Ptp10D-RI

FBtr0331406

NM_001272525

7142

1558

Additional Transcript Data and Comments

Reported size (kB)

8.2, 7.1, 6.3 (northern blot)

(Tian et al., 1991)

7.8, 6.5, 5.6 (northern blot)

(Yang et al., 1991)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Ptp10D-PB

FBpp0073369

185.1

1631

5.85

NP_727544

AAF48072

Ptp10D-PE

FBpp0271743

177.4

1558

6.01

NP_001138187

ACL82919

Ptp10D-PF

FBpp0303418

222.7

1990

4.95

NP_996413

AAS65320

Ptp10D-PG

FBpp0303419

222.7

1990

4.95

NP_996414

AAS65319

Ptp10D-PH

FBpp0303420

187.7

1653

5.95

NP_001259453

AGB95296

Ptp10D-PI

FBpp0303823

177.4

1558

6.01

NP_001259454

AGB95297

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1558 aa isoforms: Ptp10D-PE, Ptp10D-PI

1990 aa isoforms: Ptp10D-PF, Ptp10D-PG

Additional Polypeptide Data and Comments

Reported size (kDa)

1558 (aa); 177 (kD predicted)

(Tian et al., 1991)

1631, 1558 (aa); 185, 177 (kD)

(Yang et al., 1991)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

P35992

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ptp10D using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ptp10D_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

presumptive embryonic/larval central nervous system | segmentally repeated

(Tian et al., 1991)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Tian et al., 1991)

embryonic stage 12 -- 17

Comment: reference states 9-18 hr AEL

(Tian et al., 1991)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunohistochemistry

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 12 -- 17

commissure

(Tian et al., 1991)

ventral nerve cord

(Tian et al., 1991)

longitudinal connective

(Tian et al., 1991)

embryonic stage

embryonic/larval salivary gland

(Tian et al., 1991)

embryonic/larval trachea

(Tian et al., 1991)

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 13 -- 15

ventral nerve cord commissure

(Yang et al., 1991)

embryonic stage 14 -- 17

longitudinal connective

(Yang et al., 1991)

embryonic stage 12 -- 17

ventral nerve cord | restricted

(Yang et al., 1991)

embryonic stage 14

ventral nerve cord

(Qian et al., 2007)

adult stage

adult brain | restricted

(Qian et al., 2007)

adult central complex

(Qian et al., 2007)

adult mushroom body

(Qian et al., 2007)

adult antennal lobe

(Qian et al., 2007)

embryonic stage 15

embryonic/larval trachea

(Jeon and Zinn, 2009)

commissure

(Jeon and Zinn, 2009)

longitudinal connective

(Jeon and Zinn, 2009)

embryonic stage 16

ventral nerve cord | restricted

• axon

(Lee et al., 2013)

embryonic brain | restricted

(Lee et al., 2013)

embryonic/larval dorsal trunk

(Lee et al., 2013)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood & male -- day 7 of adulthood & male

spermatozoon

(Wasbrough et al., 2010)

adult stage

adult head

• membrane

(Aradska et al., 2015)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

organism

(Qian et al., 2007)

Additional Descriptive Data

In stage 16 embryos, Ptp10D antibody brightly stains axons in the ventral nerve cord (VNC) and brain, but body wall staining is weak and has no clear pattern.

(Lee et al., 2013)

Localized Ptp10D protein is first observed in the axonal layer in stage 12 embryos. By stage 14 expression is seen along the commissures and longitudinal connectives. The junctions between the anterior commissures and the longitudinal connectives are heavily stained and the posterior commissures stain more weakly than the anterior commissures. By stage 15, expression is uniform on all axons. Staining of trachea and salivary glands is also observed.

(Tian et al., 1991)

Ptp10D staining is first observed in the CNS at the end of stage 12. In stage 13, expression is seen in cell bodies (~8 cells/hemisegment) and in extending neuronal processes. Staining of longitudinal connectives is more intense than staining of commissures and no staining of the anterior and posterior fascicles is seen. Expression in the commissures fades before the expression in the longitudinal connectives.

(Yang et al., 1991)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in apical part of cell

inferred from direct assay

(Jeon and Zinn, 2009)

located_in axon

inferred from direct assay

(Jeon et al., 2008)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Ptp10D in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Ptp10D

View exonic expression by tissue for Dmel\Ptp10D

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0004370

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG1817-RB;CG1817-RC

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1817

Flygut - An atlas of the Drosophila adult midgut

FBgn0004370

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 34 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 12 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Ptp10D

Transgenic constructs containing regulatory region of Ptp10D

Deletions and Duplications ( 0 )

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Ptp10D^GD2611

lethal - all die during embryonic stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Ptp10D^GD2611

partially lethal - majority die, with Scer\GAL4^pnr-MD237

Ptp10D^GD115

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Ptp10D^GD115

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

Ptp10D^GD2611

viable, with Scer\GAL4^tin.CΔ4

Sterility

Allele

female semi-sterile, with Scer\GAL4^{VP16.mat.αTub67C}

Ptp10D^HMS01917

fertile

Other Phenotypes

Allele

memory defective

memory defective (with Ptp10D^chi)

Ptp10D^EP1172

memory defective (with Ptp10D^EP1172)

Ptp10D^chi

neuroanatomy defective, with Scer\GAL4^ppk.PG

neuroanatomy defective | larval stage

Ptp10D¹

neuroanatomy defective | larval stage, with Scer\GAL4^elav-C155

Ptp10D^EP1172

some die during pupal stage, with Scer\GAL4^pnr-MD237

Ptp10D^GD115

visible, with Scer\GAL4^pnr-MD237

Ptp10D^GD2611

Phenotype manifest in

Allele

abdominal dorsal multidendritic neuron ddaC | third instar larval stage, with Scer\GAL4^ppk.PG

anterior fascicle & synapse, with Scer\GAL4^elav-C155

Ptp10D^EP1172

dendritic tree | third instar larval stage, with Scer\GAL4^ppk.PG

embryo | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

Ptp10D^HMS01917

embryonic/larval optic lobe (with Df(1)Δ59)

Ptp10D¹

intersegmental nerve

Ptp10D¹

intersegmental nerve, with Scer\GAL4^elav-C155

Ptp10D^EP1172

macrochaeta

Ptp10D^BG01595

trichogen cell, with Scer\GAL4^pnr-MD237

Ptp10D^GD2611

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (11)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\PTPRB

11 of 15

Yes

Hsap\PTPRJ

6 of 15

Yes

Hsap\PTPRH

5 of 15

Yes

Hsap\PTPRO

4 of 15

Yes

Hsap\COL20A1

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (11)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Ptprb

12 of 15

Yes

Mmus\Ptprh

5 of 15

Yes

Mmus\Ptprj

5 of 15

Mmus\Ptpro

4 of 15

Mmus\Col20a1

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Mmus\Ptprz1

1 of 15

Rattus norvegicus (Norway rat) (6)

Rnor\Ptprb

4 of 13

Yes

Rnor\Ptpro

4 of 13

Yes

3 of 13

2 of 13

2 of 13

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (8)

Xtro\ptprb

6 of 12

Yes

3 of 12

2 of 12

2 of 12

1 of 12

Yes

Xtro\igdcc4

1 of 12

Xtro\LOC100493594

1 of 12

Xtro\LOC105945771

1 of 12

Danio rerio (Zebrafish) (14)

Drer\ptprb

10 of 15

Yes

Drer\ptprja

5 of 15

Drer\ptpro

5 of 15

Yes

3 of 15

2 of 15

2 of 15

2 of 15

1 of 15

Yes

Drer\LOC101885876

1 of 15

Yes

Drer\ptpn22

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (15)

Cele\dep-1

11 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Arabidopsis thaliana (thale-cress) (1)

Atha\PTP1

3 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (3)

Scer\PTP1

3 of 15

Yes

Scer\PTP2

1 of 15

Scer\PTP3

1 of 15

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\pyp2

2 of 12

Yes

Spom\pyp3

2 of 12

Yes

Spom\pyp1

1 of 12

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091900B5 )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA14821

Drosophila persimilis

Dper\GL13110

Drosophila willistoni

Dwil\GK25195

Drosophila mojavensis

Dmoj\GI16226

Drosophila grimshawi

Dgri\GH12596

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500DW )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17016134

Glossina morsitans

Tsetse fly

Gmor\GMOY009213

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_13816

Mayetiola destructor

Hessian fly

Mdes\Mdes005175

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL012083

Anopheles darlingi

American malaria mosquito

Adar\ADAC004290

Anopheles gambiae

Malaria mosquito

Agam\GPXH1

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ006052

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00EY )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA001078

Bombyx mori

Silkmoth

Bmor\BGIBMGA001079

Danaus plexippus

Monarch butterfly

Dple\DPOGS215963-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL005888

Apis florea

Little honeybee

Aflo\2147485553

Apis mellifera

Western honey bee

Amel\GB45612

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP10281

Bombus terrestris

Buff-tailed bumblebee

Bter\15212938

Linepithema humile

Argentine ant

Lhum\LH11081

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:00075c

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG009079

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_03484

Tribolium castaneum

Red flour beetle

Tcas\GLEAN_07672

Pediculus humanus

Human body louse

Phum\PHUM530510

Rhodnius prolixus

Kissing bug

Rpro\RPRC000896

Rhodnius prolixus

Kissing bug

Rpro\RPRC012423

Cimex lectularius

Bed bug

Clec\CLEC002490-PC

Cimex lectularius

Bed bug

Clec\CLEC002490-PB

Cimex lectularius

Bed bug

Clec\CLEC002490

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI006943

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_04740

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00DY )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR011033

Ixodes scapularis

Black-legged tick

Isca\ISCW022067

Stegodyphus mimosarum

African social velvet spider

Smim\KFM77963.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM71044.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur01g04890

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_306015

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G00JF )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-R/Ptp/B

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Fn3f_8

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Fn3_2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Fn3

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Fn3_16

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Fn3_22

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Hhat

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-PtprbL

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_011327gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-PtprB

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Fn3_17

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Ptpd

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Fn3_8

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Fn3_32

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Fn3_29

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Srcr/Ptpc1

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000014059

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000003151

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000004644

Gallus gallus

Domestic chicken

Ggal\PTPRB

Gallus gallus

Domestic chicken

Ggal\PTPRJ

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000000584

Gallus gallus

Domestic chicken

Ggal\PTPRO

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (14)

Gene Symbol

Score

Source

Alignment

8 of 10

4 of 10

Lar

3 of 10

2 of 10

2 of 10

2 of 10

2 of 10

1 of 10

csw

1 of 10

IA-2

1 of 10

Pez

1 of 10

Ptp61F

1 of 10

Ptp99A

1 of 10

Ptpmeg

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

PTPRJ; protein tyrosine phosphatase receptor type J

model of colorectal cancer

IEA

(FlyBase, 2019-)

PTPRO; protein tyrosine phosphatase receptor type O

model of nephrotic syndrome type 6

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

Ptp10D^GD115

exacerbates Parkinson's disease

modeled by Hsap\SNCA^UAS.cJa

(Jansen et al., 2017)

Ptp10D^GD2611

exacerbates Parkinson's disease

modeled by Hsap\SNCA^UAS.cJa

(Jansen et al., 2017)

Ptp10D^KK101775

exacerbates Parkinson's disease

modeled by Hsap\SNCA^UAS.cJa

(Jansen et al., 2017)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PTPRB; protein tyrosine phosphatase receptor type B

11 of 15

176882

PTPRJ; protein tyrosine phosphatase receptor type J

6 of 15

600925

COLORECTAL CANCER; CRC

colorectal cancer

PTPRH; protein tyrosine phosphatase receptor type H

5 of 15

602510

PTPRO; protein tyrosine phosphatase receptor type O

4 of 15

600579

NEPHROTIC SYNDROME, TYPE 6; NPHS6

nephrotic syndrome type 6

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Ptp10D

pull down, anti tag western blot

(Tian and Zinn, 1994)

Ptp10D - Btk29A

anti bait coimmunoprecipitation, western blot

(Tsarouhas et al., 2019)

Ptp10D - Egfr

anti tag coimmunoprecipitation, anti tag western blot

(Jeon and Zinn, 2009)

Ptp10D - Gp150

enzymatic study, phosphatase assay, pull down, edman degradation, autoradiography

(Madan and Gopal, 2011, Tian and Zinn, 1994)

Ptp10D - Rpp20

two hybrid

(Bugga et al., 2009)

Ptp10D - ena

pull down, western blot

(Wills et al., 1999)

Ptp10D - sas

affinity technology, tag visualisation, inferred by author, pull down, enzyme linked immunosorbent assay, bead aggregation assay, fluorescence microscopy

(Lee et al., 2013)

Ptp10D - xmas

two hybrid

(Bugga et al., 2009)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Ptp10D|Ptp4E

suppressible

btl

(Jeon and Zinn, 2009)

Ptp4E|Ptp10D

enhanceable

btl

(Jeon and Zinn, 2009)

Ptp10D|Ptp4E

enhanceable

Egfr

(Jeon and Zinn, 2009)

Ptp10D|Ptp4E

suppressible

Egfr

(Jeon and Zinn, 2009)

Ptp10D|Ptp4E

suppressible

exp

(Iordanou et al., 2014)

Ptp4E|Ptp10D

enhanceable

Raf

(Jeon and Zinn, 2009)

Ptp69D|Ptp10D

enhanceable

sli

(Sun et al., 2000)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Sun et al., 2000)

suppressible

(Jeon et al., 2008)

Ptp52F

enhanceable

Ptp10D

(Schindelholz et al., 2001)

Ptp52F

enhanceable

Ptp10D|Ptp4E

(Jeon et al., 2008)

sas

enhanceable

Ptp10D

(Lee et al., 2013)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

58524

DroID - A comprehensive database of gene and protein interactions.

FBgn0004370

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

32115

MIST (genetic) - An integrated Molecular Interaction Database

Ptp10D

MIST (protein-protein) - An integrated Molecular Interaction Database

Ptp10D

Pathways

Signaling Pathways (FlyBase)

Negative Regulators of EGFR Signaling Pathway -: Negative regulators of Epidermal Growth Factor Receptor signaling down-regulate the pathway, suppressing the activation of ERK kinase (rl) or acting on downstream effectors.
Negative Regulators of Pvr Signaling Pathway -: Negative regulators of Platelet-derived Growth Factor-Vascular Endothelial Growth Factor Receptor-related (Pvr) signaling down-regulate the pathway.
Negative Regulators of FGFR Signaling Pathway -: Negative regulators of Fibroblast Growth Factor Receptor signaling down-regulate the pathway, suppressing the activation of ERK kinase (rl) or acting on other effectors.

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-35

Cytogenetic map

10D1-10D4

Sequence location

X:11,622,015..11,677,338 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

10D1-10D4

Limits computationally determined from genome sequence between P{EP}CG32666^EP1452 and P{EP}Ptp10D^EP1172

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

10D-10D

(determined by in situ hybridisation)

(Tian et al., 1991, Yang et al., 1991)

Experimentally Determined Recombination Data

Location

1-35

(FlyBase, 2016)

1-36.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (21)

Bloomington

5810

w^* Ptp10D¹

11332

w¹¹¹⁸ P{EP}Ptp10D^EP1172

Kyoto

108436

w^* Ptp10D¹/FM7c

123821

w¹¹¹⁸ P{RS3}Ptp10D^CB-5793-3

124003

w¹¹¹⁸ P{RS3}Ptp10D^CB-6260-3

126062

w¹¹¹⁸ P{RS5}Ptp10D^5-SZ-3438

112187

w^* P{GawB}Ptp10D^NP0438 / FM7c

v110443

v1101

v1102

v8010

w¹¹¹⁸; P{GD2611}v8010

v1104

w¹¹¹⁸; P{GD115}v1104/TM3

More stocks available...

Genomic Clones (20)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (62)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE52018

Other clones

RT11161

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0004370

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0004370

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32115

Antibody Information

Laboratory Generated Antibodies

monoclonal

(Tian et al., 1991)

polyclonal

(Yang et al., 1991)

Commercially Available Antibodies

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

8B22F5
45E10

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Ptp10D CG1817

(Wang, 1999.11)

Source for database merge of

Additional comments

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Ptp10D and Ptp69D are necessary for repulsion of growth cones from the midline of the embryonic central nervous system.

(Sun et al., 2000)

Ptp10D and shg form stable complexes in culture cells and in wild type larval tissue. Ptp10D cytoplasmic domain is sufficient to confer binding to shg. Results support the hypothesis that Ptp10D regulates shg signaling in vivo.

(Fashena and Zinn, 1997)

Spatial and temporal transcript accumulation pattern in ovaries is determined by in situ hybridisation.

(Fitzpatrick et al., 1995)

Transmembrane Gp150 glycoprotein selectively interacts with the active site of the catalytic domain of Ptp10D (interaction is blocked by mutation of the active site or by the inhibitor vanadate). Ptp10D may function in vivo to regulate phosphorylation of Gp150 thereby controlling interactions with downstream effectors.

(Tian and Zinn, 1994)

A 150kD transmembrane protein, Gp150, binds to the Ptp10D cytoplasmic domain.

(Tian et al., 1993)

Receptor linked PTPases may be involved in axon outgrowth and guidance during embryonic development.

(Tian et al., 1991)

Ptp10D has been characterised. Ptp10D transcripts and proteins are localised exclusively to the CNS, and expression coincides temporally with axon outgrowth.

(Yang et al., 1991)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 161 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32115

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

AJ569651
AJ569652
AJ569653
AJ569654
AJ569656
AJ569657
AJ569658
AJ569659
AJ569660
AJ569661
AJ569662
AJ569663
AJ569664
AJ569665
AJ569667
AJ569668
AJ569669
AJ569670
AJ569671
AJ569672
AJ569673
AJ569674
AJ569675
AJ569678
AJ569679
AJ569680
AJ569681
AJ569682
AJ569683
AJ569684
AJ569685
AJ569686
AJ569687
AJ569689
AJ569690
AJ569691
AJ569692
AJ569693
AJ569694
AJ569695
AJ569696
AJ569697
AJ569698
AJ569700
AJ569701
AJ569702
AJ569703
AJ889255
AJ889256
AJ889257
AJ889258
AJ889259
AJ889260
AJ889261
AJ889262
AJ889263
AJ889264
AJ889265
AJ889266
AJ889267
AJ889268
AJ889269
AJ889270
AJ889271
AJ889272
AJ889273
AJ889274
AJ889275
AJ889276
AJ889277
AJ889278
AJ889279
AJ889280
AJ889281
AJ889282
AJ889283
AJ889284
AJ889285
AJ889286
AJ889287
AJ889288
AJ889289
AJ889290
AJ889291
AJ889292
AJ889293
AJ889294
AJ889295
AJ889296
AJ889297
AJ889298
AJ889299
AQ025398
AQ025427
AQ073197
BH011504
BI366463
BT004474
CZ469214
CZ472158
CZ472484
CZ476591
CZ476592
CZ478522
CZ478523
CZ483420
CZ489162
M80465
M80538

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P35992

Other crossreferences

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0004370

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ptp10D_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1817

Flygut - An atlas of the Drosophila adult midgut

FBgn0004370

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32115

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC007672

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG1817

modMine - A data warehouse for the modENCODE project

FBgn0004370

Linkouts

BioGRID - A database of protein and genetic interactions.

58524

DroID - A comprehensive database of gene and protein interactions.

FBgn0004370

DRSC - Results frm RNAi screens

FBgn0004370

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

8B22F5
45E10

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0004370

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG1817-RB;CG1817-RC

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0004370

FlyMine - An integrated database for Drosophila genomics

FBgn0004370

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

32115

MIST (genetic) - An integrated Molecular Interaction Database

Ptp10D

MIST (protein-protein) - An integrated Molecular Interaction Database

Ptp10D

Synonyms and Secondary IDs (17)

Reported As

Symbol Synonym

10D

(Lee et al., 2013)

CG1817

(Hosono et al., 2015, Lee et al., 2013, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Schiess et al., 2009, Norga et al., 2003, Kraut et al., 2001, Kraut et al., 2001, Morrison et al., 2000)

CT4920

(Hynes and Zhao, 2000)

DPTP

(Walchli et al., 2000)

DPTP_10D

(Tian et al., 1991)

PTP10D

(Enomoto et al., 2018, Richardson and Portela, 2018, Baker, 2017, Yamamoto et al., 2017, Das et al., 2013, Madan and Gopal, 2011, Hofmeyer and Treisman, 2009, Qian et al., 2007, Andersen et al., 2004, Rao et al., 2002, Koushika et al., 2000)

Ptp10

(McGovern and Seeger, 2001)

Ptp10d

(Fujisawa et al., 2020)

R-PTP 10D

(Morrison et al., 2000)

RPTP10d

(Oliva et al., 2016)

dptp

(Babu et al., 2005)

ptp10D

(Hu, 2005)

ptp10d

(Xu et al., 2014)

Name Synonyms

Protein tyrosine phosphatase 10B

(Siddiqui et al., 2012)

Protein tyrosine phosphatase 10D

(Jeon and Zinn, 2015)

Secondary FlyBase IDs

FBgn0019946

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (140)

The following external sites may use different assemblies or annotations than FlyBase.

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