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Gene Dmel\Ptp10D

General Information
Symbol	Dmel\Ptp10D	Species	D. melanogaster
Name	Protein tyrosine phosphatase 10D	Annotation symbol	CG1817
Feature type	protein_coding_gene	FlyBase ID	FBgn0004370
Gene Model Status	Current	Stock availability	23 publicly available
Also Known As	DPTP10D, DPTP
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	10D1-10D4	Sequence location	X:11,516,048..11,571,371 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Protein tyrosine phosphatase 10D is referred to in FlyBase by the symbol Dmel\Ptp10D (CG1817, FBgn0004370). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: phosphoprotein phosphatase activity; protein tyrosine phosphatase activity. There is experimental evidence that it is involved in the biological process: motor neuron axon guidance; central nervous system development; protein dephosphorylation; long-term memory; open tracheal system development. 45 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; macrochaeta; embryonic/larval optic neuropil; intersegmental nerve. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: Fibronectin, type III; Immunoglobulin-like fold; Protein-tyrosine phosphatase, active site; Protein-tyrosine phosphatase, receptor/non-receptor type; Protein-tyrosine/Dual specificity phosphatase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression in all larval and adult organs/tissues ranges from low to undetected. Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, larval hindgut, larval trachea, adult ovary, larval carcass. Gene sequence location is X:11516048..11571371.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 10D1-10D4   Limits computationally determined from genome sequence between P{EP}CG32666EP1452 and P{EP}Ptp10DEP1172
Experimentally Determined Cytological Location
Cytogenetic map Notes References 10D-10D   (determined by in situ hybridisation)   (Tian et al., 1991) 10D-10D   (determined by in situ hybridisation)   (Yang et al., 1991)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ptp10D for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Stop-codon suppression (UGA) postulated; FBrf0216884. gene_with_stop_codon_read_through ; SO:0000697 Gene model reviewed during 5.44 Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Low-frequency RNA-Seq exon junction(s) not annotated. Annotated transcripts do not represent all supported alternative splices within 5' UTR. Gene model reviewed during 5.46 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated Transposon inserted in intron
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ptp10D-RB FBtr0073522  NM_167292   7308   1631 Ptp10D-RE FBtr0273235  NM_001144715   7269   1558 Ptp10D-RF FBtr0330392  NM_206690   7385   1990 Ptp10D-RG FBtr0330393  NM_206691   8642   1990 Ptp10D-RH FBtr0330394  NM_001272524   8335   1653 Ptp10D-RI FBtr0331406  NM_001272525   7142   1558
Additional Transcript Data & Comments
Reported size (kB)	8.2, 7.1, 6.3 (northern blot) (Tian et al., 1991) 7.8, 6.5, 5.6 (northern blot) (Yang et al., 1991)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ptp10D-PB   FBpp0073369   185.1   1631   5.85     NP_727544   AAF48072 Ptp10D-PE   FBpp0271743   177.4   1558   6.01     NP_001138187   ACL82919 Ptp10D-PF   FBpp0303418   222.7   1990   4.95     NP_996413   AAS65320 Ptp10D-PG   FBpp0303419   222.7   1990   4.95     NP_996414   AAS65319 Ptp10D-PH   FBpp0303420   187.7   1653   5.95     NP_001259453   AGB95296 Ptp10D-PI   FBpp0303823   177.4   1558   6.01     NP_001259454   AGB95297
Additional Polypeptide Data & Comments
Reported size (kDa)	1631, 1558 (aa); 185, 177 (kD) (Yang et al., 1991) 1558 (aa); 177 (kD predicted) (Tian et al., 1991)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein-tyrosine phosphatase, receptor/non-receptor type (IPR000242) Protein-tyrosine/Dual specificity phosphatase (IPR000387) Fibronectin, type III (IPR003961) Protein-tyrosine phosphatase, active site (IPR016130) Immunoglobulin-like fold (IPR013783)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141418   AE014298 AAF48072   AE014298 AAS65319   AE014298 AAS65320   AE014298 ACL82919   AE014298 AGB95296   AE014298 AGB95297   AI259117   AI387184   AI512358   AJ569651   AJ569652   AJ569653   AJ569654   AJ569656   AJ569657   AJ569658   AJ569659   AJ569660   AJ569661   AJ569662   AJ569663   AJ569664   AJ569665   AJ569667   AJ569668   AJ569669   AJ569670   AJ569671   AJ569672   AJ569673   AJ569674   AJ569675   AJ569678   AJ569679   AJ569680   AJ569681   AJ569682   AJ569683   AJ569684   AJ569685   AJ569686   AJ569687   AJ569689   AJ569690   AJ569691   AJ569692   AJ569693   AJ569694   AJ569695   AJ569696   AJ569697   AJ569698   AJ569700   AJ569701   AJ569702   AJ569703   AJ889255   AJ889256   AJ889257   AJ889258   AJ889259   AJ889260   AJ889261   AJ889262   AJ889263   AJ889264   AJ889265   AJ889266   AJ889267   AJ889268   AJ889269   AJ889270   AJ889271   AJ889272   AJ889273   AJ889274   AJ889275   AJ889276   AJ889277   AJ889278   AJ889279   AJ889280   AJ889281   AJ889282   AJ889283   AJ889284   AJ889285   AJ889286   AJ889287   AJ889288   AJ889289   AJ889290   AJ889291   AJ889292   AJ889293   AJ889294   AJ889295   AJ889296   AJ889297   AJ889298   AJ889299   AQ025398   AQ025427   AQ073197   BE977248   BG637296   BH011504   BI366463   BI608853   BI611607   BI618668   BT004474 AAO42638   BT126065   CK135496   CO153000   CO154322   CO154889   CO155460   CO155900   CO156926   CO187516   CO265674   CO268590   CO270970   CO273255   CO279049   CO286018   CO286630   CO290965   CO295199   CO301286   CO302323   CO305178   CO308219   CO308889   CO309625   CO323889   CZ469214   CZ472158   CZ472484   CZ476591   CZ476592   CZ478522   CZ478523   CZ483420   CZ489162   EC069915   EC071016   EC077235   EC077650   EC082411   EC087414   EC195096   EC200093   EC206985   EC208783   EC219244   EC221769   EC223749   EC228948   EC230900   EC231617   EC236115   EC243801   EC246116   EC256465   EC267378   GH796540   GH805736   GH808549   GH810758   GH812132   GH813533   GH883872   GH905999   GH916262   GH929163   GH963917   GH967267   M80465 AAA28484   M80538 AAA28952
UniProtKB/Swiss-Prot	P35992
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   presumptive embryonic/larval central nervous system | segmentally repeated   (Tian et al., 1991) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Tian et al., 1991) embryonic stage 12 -- 17     (Tian et al., 1991) Comment:reference states 9-18 hr AEL
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunohistochemistry Stage Tissue/Position (including subcellular localization) Reference embryonic stage   embryonic/larval salivary gland   (Tian et al., 1991) embryonic/larval trachea   (Tian et al., 1991) embryonic stage 12 -- 17   commissure   (Tian et al., 1991) ventral nerve cord   (Tian et al., 1991) longitudinal connective   (Tian et al., 1991) immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 12 -- 17   ventral nerve cord | restricted   (Yang et al., 1991) embryonic stage 13 -- 15   ventral nerve cord commissure   (Yang et al., 1991) embryonic stage 14   ventral nerve cord   (Qian et al., 2007) embryonic stage 14 -- 17   longitudinal connective   (Yang et al., 1991) adult stage   adult brain | restricted   (Qian et al., 2007) adult central complex   (Qian et al., 2007) adult mushroom body   (Qian et al., 2007) adult antennal lobe   (Qian et al., 2007) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010) western blot Stage Tissue/Position (including subcellular localization) Reference adult stage   organism   (Qian et al., 2007)
Additional Descriptive Data
	Ptp10D staining is first observed in the CNS at the end of stage 12. In stage 13, expression is seen in cell bodies (~8 cells/hemisegment) and in extending neuronal processes. Staining of longitudinal connectives is more intense than staining of commissures and no staining of the anterior and posterior fascicles is seen. Expression in the commissures fades before the expression in the longitudinal connectives. (Yang et al., 1991) Localized Ptp10D protein is first observed in the axonal layer in stage 12 embryos. By stage 14 expression is seen along the commissures and longitudinal connectives. The junctions between the anterior commissures and the longitudinal connectives are heavily stained and the posterior commissures stain more weakly than the anterior commissures. By stage 15, expression is uniform on all axons. Staining of trachea and salivary glands is also observed. (Tian et al., 1991)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
apical part of cell inferred from direct assay (Jeon and Zinn, 2009) axon inferred from direct assay (Jeon et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression in all larval and adult organs/tissues ranges from low to undetected. Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, larval hindgut, larval trachea, adult ovary, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    24 central nervous system, pupae P8    42 head, virgin 1-day female    14 head, virgin 4-day female    10 head, virgin 20-day female    6 head, mated 1-day female    12 head, mated 4-day female    8 head, mated 20-day female    6 head, mated 1-day male    16 head, mated 4-day male    13 head, mated 20-day male    11 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    2 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    23 carcass, larvae L3 wandering    18 carcass, 1-day adult    9 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female    11 ovary, mated 4-day female    13 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    24 central nervous system, pupae P8  (42) head, virgin 1-day female    14 head, virgin 4-day female    10 head, virgin 20-day female    6 head, mated 1-day female    12 head, mated 4-day female    8 head, mated 20-day female    6 head, mated 1-day male    16 head, mated 4-day male    13 head, mated 20-day male    11 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    2 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    23 carcass, larvae L3 wandering    18 carcass, 1-day adult    9 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female    11 ovary, mated 4-day female    13 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    24 central nervous system, pupae P8    42 head, virgin 1-day female    14 head, virgin 4-day female    10 head, virgin 20-day female    6 head, mated 1-day female    12 head, mated 4-day female    8 head, mated 20-day female    6 head, mated 1-day male    16 head, mated 4-day male    13 head, mated 20-day male    11 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    2 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    23 carcass, larvae L3 wandering    18 carcass, 1-day adult    9 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female    11 ovary, mated 4-day female    13 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    24 central nervous system, pupae P8    42 head, virgin 1-day female    14 head, virgin 4-day female    10 head, virgin 20-day female    6 head, mated 1-day female    12 head, mated 4-day female    8 head, mated 20-day female    6 head, mated 1-day male    16 head, mated 4-day male    13 head, mated 20-day male    11 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    2 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    23 carcass, larvae L3 wandering    18 carcass, 1-day adult    9 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female    11 ovary, mated 4-day female    13 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    24 central nervous system, pupae P8    42 head, virgin 1-day female    14 head, virgin 4-day female    10 head, virgin 20-day female    6 head, mated 1-day female    12 head, mated 4-day female    8 head, mated 20-day female    6 head, mated 1-day male    16 head, mated 4-day male    13 head, mated 20-day male    11 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    2 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    23 carcass, larvae L3 wandering    18 carcass, 1-day adult    9 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female    11 ovary, mated 4-day female    13 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    24 central nervous system, pupae P8  (42) head, virgin 1-day female    14 head, virgin 4-day female    10 head, virgin 20-day female    6 head, mated 1-day female    12 head, mated 4-day female    8 head, mated 20-day female    6 head, mated 1-day male    16 head, mated 4-day male    13 head, mated 20-day male    11 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    2 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    23 carcass, larvae L3 wandering    18 carcass, 1-day adult    9 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female    11 ovary, mated 4-day female    13 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    24 central nervous system, pupae P8    42 head, virgin 1-day female    14 head, virgin 4-day female    10 head, virgin 20-day female    6 head, mated 1-day female    12 head, mated 4-day female    8 head, mated 20-day female    6 head, mated 1-day male    16 head, mated 4-day male    13 head, mated 20-day male    11 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    2 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    23 carcass, larvae L3 wandering    18 carcass, 1-day adult    9 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female    11 ovary, mated 4-day female    13 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    24 central nervous system, pupae P8    42 head, virgin 1-day female    14 head, virgin 4-day female    10 head, virgin 20-day female    6 head, mated 1-day female    12 head, mated 4-day female    8 head, mated 20-day female    6 head, mated 1-day male    16 head, mated 4-day male    13 head, mated 20-day male    11 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    2 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    23 carcass, larvae L3 wandering    18 carcass, 1-day adult    9 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female    11 ovary, mated 4-day female    13 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    23 embryo 04-06hr    7 embryo 06-08hr    8 embryo 08-10hr    15 embryo 10-12hr    20 embryo 12-14hr    24 embryo 14-16hr    44 embryo 16-18hr    38 embryo 18-20hr    24 embryo 20-22hr    26 embryo 22-24hr    24 larva L1    13 larva L2    13 larva L3 12hr old    11 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    14 white prepupae new    16 white prepupae 12hr    30 white prepupae 24hr    30 pupae 2d postWPP    44 pupae 3d postWPP    18 pupae 4d postWPP    15 adult male 01day    12 adult male 05day    12 adult male 30day    14 adult female 01day    16 adult female 05day    16 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (27) embryo 02-04hr    23 embryo 04-06hr    7 embryo 06-08hr    8 embryo 08-10hr    15 embryo 10-12hr    20 embryo 12-14hr    24 embryo 14-16hr  (44) embryo 16-18hr  (38) embryo 18-20hr    24 embryo 20-22hr  26 embryo 22-24hr    24 larva L1    13 larva L2    13 larva L3 12hr old    11 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    14 white prepupae new    16 white prepupae 12hr  (30) white prepupae 24hr  (30) pupae 2d postWPP  (44) pupae 3d postWPP    18 pupae 4d postWPP    15 adult male 01day    12 adult male 05day    12 adult male 30day    14 adult female 01day    16 adult female 05day    16 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    23 embryo 04-06hr    7 embryo 06-08hr    8 embryo 08-10hr    15 embryo 10-12hr    20 embryo 12-14hr    24 embryo 14-16hr    44 embryo 16-18hr    38 embryo 18-20hr    24 embryo 20-22hr    26 embryo 22-24hr    24 larva L1    13 larva L2    13 larva L3 12hr old    11 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    14 white prepupae new    16 white prepupae 12hr    30 white prepupae 24hr    30 pupae 2d postWPP    44 pupae 3d postWPP    18 pupae 4d postWPP    15 adult male 01day    12 adult male 05day    12 adult male 30day    14 adult female 01day    16 adult female 05day    16 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    23 embryo 04-06hr    7 embryo 06-08hr    8 embryo 08-10hr    15 embryo 10-12hr    20 embryo 12-14hr    24 embryo 14-16hr    44 embryo 16-18hr    38 embryo 18-20hr    24 embryo 20-22hr    26 embryo 22-24hr    24 larva L1    13 larva L2    13 larva L3 12hr old    11 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    14 white prepupae new    16 white prepupae 12hr    30 white prepupae 24hr    30 pupae 2d postWPP    44 pupae 3d postWPP    18 pupae 4d postWPP    15 adult male 01day    12 adult male 05day    12 adult male 30day    14 adult female 01day    16 adult female 05day    16 adult female 30day    16 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    23 embryo 04-06hr    7 embryo 06-08hr    8 embryo 08-10hr    15 embryo 10-12hr    20 embryo 12-14hr    24 embryo 14-16hr    44 embryo 16-18hr    38 embryo 18-20hr    24 embryo 20-22hr    26 embryo 22-24hr    24 larva L1    13 larva L2    13 larva L3 12hr old    11 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    14 white prepupae new    16 white prepupae 12hr    30 white prepupae 24hr    30 pupae 2d postWPP    44 pupae 3d postWPP    18 pupae 4d postWPP    15 adult male 01day    12 adult male 05day    12 adult male 30day    14 adult female 01day    16 adult female 05day    16 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  27 embryo 02-04hr    23 embryo 04-06hr    7 embryo 06-08hr    8 embryo 08-10hr    15 embryo 10-12hr    20 embryo 12-14hr    24 embryo 14-16hr  (44) embryo 16-18hr  (38) embryo 18-20hr    24 embryo 20-22hr  26 embryo 22-24hr    24 larva L1    13 larva L2    13 larva L3 12hr old    11 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    14 white prepupae new    16 white prepupae 12hr  30 white prepupae 24hr  30 pupae 2d postWPP  (44) pupae 3d postWPP    18 pupae 4d postWPP    15 adult male 01day    12 adult male 05day    12 adult male 30day    14 adult female 01day    16 adult female 05day    16 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    23 embryo 04-06hr    7 embryo 06-08hr    8 embryo 08-10hr    15 embryo 10-12hr    20 embryo 12-14hr    24 embryo 14-16hr    44 embryo 16-18hr    38 embryo 18-20hr    24 embryo 20-22hr    26 embryo 22-24hr    24 larva L1    13 larva L2    13 larva L3 12hr old    11 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    14 white prepupae new    16 white prepupae 12hr    30 white prepupae 24hr    30 pupae 2d postWPP    44 pupae 3d postWPP    18 pupae 4d postWPP    15 adult male 01day    12 adult male 05day    12 adult male 30day    14 adult female 01day    16 adult female 05day    16 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    23 embryo 04-06hr    7 embryo 06-08hr    8 embryo 08-10hr    15 embryo 10-12hr    20 embryo 12-14hr    24 embryo 14-16hr    44 embryo 16-18hr    38 embryo 18-20hr    24 embryo 20-22hr    26 embryo 22-24hr    24 larva L1    13 larva L2    13 larva L3 12hr old    11 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    14 white prepupae new    16 white prepupae 12hr    30 white prepupae 24hr    30 pupae 2d postWPP    44 pupae 3d postWPP    18 pupae 4d postWPP    15 adult male 01day    12 adult male 05day    12 adult male 30day    14 adult female 01day    16 adult female 05day    16 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    4 embryonic 1182-4H    26 embryonic GM2    4 embryonic Kc167    3 embryonic S1    5 embryonic S3    7 leg disc CME L1    3 wing disc CME-W2    7 wing disc ML-DmD8    20 wing disc ML-DmD9    31 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    8 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    39 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    13 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    5 ovary fGS/OSS    17 ovary OSC    12 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    4 embryonic 1182-4H  26 embryonic GM2    4 embryonic Kc167    3 embryonic S1    5 embryonic S3    7 leg disc CME L1    3 wing disc CME-W2    7 wing disc ML-DmD8    20 wing disc ML-DmD9  (31) wing disc ML-DmD16-c3    15 wing disc ML-DmD21    8 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11  (39) antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    13 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    5 ovary fGS/OSS    17 ovary OSC    12 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    4 embryonic 1182-4H    26 embryonic GM2    4 embryonic Kc167    3 embryonic S1    5 embryonic S3    7 leg disc CME L1    3 wing disc CME-W2    7 wing disc ML-DmD8    20 wing disc ML-DmD9    31 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    8 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    39 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    13 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    5 ovary fGS/OSS    17 ovary OSC    12 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    4 embryonic 1182-4H    26 embryonic GM2    4 embryonic Kc167    3 embryonic S1    5 embryonic S3    7 leg disc CME L1    3 wing disc CME-W2    7 wing disc ML-DmD8    20 wing disc ML-DmD9    31 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    8 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    39 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    13 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    5 ovary fGS/OSS    17 ovary OSC    12 ovary OSS    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    4 embryonic 1182-4H    26 embryonic GM2    4 embryonic Kc167    3 embryonic S1    5 embryonic S3    7 leg disc CME L1    3 wing disc CME-W2    7 wing disc ML-DmD8    20 wing disc ML-DmD9    31 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    8 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    39 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    13 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    5 ovary fGS/OSS    17 ovary OSC    12 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    4 embryonic 1182-4H  26 embryonic GM2    4 embryonic Kc167    3 embryonic S1    5 embryonic S3    7 leg disc CME L1    3 wing disc CME-W2    7 wing disc ML-DmD8    20 wing disc ML-DmD9  31 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    8 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11  (39) antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    13 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    5 ovary fGS/OSS    17 ovary OSC    12 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    4 embryonic 1182-4H    26 embryonic GM2    4 embryonic Kc167    3 embryonic S1    5 embryonic S3    7 leg disc CME L1    3 wing disc CME-W2    7 wing disc ML-DmD8    20 wing disc ML-DmD9    31 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    8 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    39 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    13 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    5 ovary fGS/OSS    17 ovary OSC    12 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    4 embryonic 1182-4H    26 embryonic GM2    4 embryonic Kc167    3 embryonic S1    5 embryonic S3    7 leg disc CME L1    3 wing disc CME-W2    7 wing disc ML-DmD8    20 wing disc ML-DmD9    31 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    8 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    39 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    13 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    5 ovary fGS/OSS    17 ovary OSC    12 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_27 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004370 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1817-RB;CG1817-RC
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 Ptp10DGD115 viable Ptp10D1 Ptp10D101 Ptp10DCC06344 viable, with Scer\GAL4pnr-MD237 Ptp10DGD2611 Sterility Allele fertile Ptp10D1 Ptp10D101 Other Phenotypes Allele memory defective Ptp10Dchi Ptp10DEP1172 memory defective (with Ptp10Dchi) Ptp10DEP1172 memory defective (with Ptp10DEP1172) Ptp10Dchi neuroanatomy defective | larval stage Ptp10D1 neuroanatomy defective | larval stage, with Scer\GAL4elav-C155 Ptp10DEP1172 visible, with Scer\GAL4pnr-MD237 Ptp10DGD2611 Phenotype manifest in Allele anterior fascicle & synapse, with Scer\GAL4elav-C155 Ptp10DEP1172 embryonic/larval optic neuropil (with Df(1)Δ59) Ptp10D1 intersegmental nerve Ptp10D1 intersegmental nerve, with Scer\GAL4elav-C155 Ptp10DEP1172 macrochaeta Ptp10DBG01595 trichogen cell, with Scer\GAL4pnr-MD237 Ptp10DGD2611
Classical Alleles ( 32 )
For All Classical Alleles Show
Allele of Ptp10D Class Mutagen Stocks Known lesion Ptp10D1 P-element activity 3 Yes Ptp10D5-SZ-3438 1 -- Ptp10DBG02428 P-element activity 1 -- Ptp10Dc04386 piggyBac transposase 1 -- Ptp10DCB-5793-3 1 -- Ptp10DCB-6260-3 1 -- Ptp10Dd01321 P-element activity 1 -- Ptp10De00662 piggyBac transposase 1 -- Ptp10DEP1172 P-element activity 1 Yes Ptp10Df00941 piggyBac transposase 1 -- Ptp10Df06456 1 -- Ptp10Df06457 piggyBac transposase 1 -- Ptp10DMB02913 1 -- Ptp10DNP0438 1 -- Ptp10DNP1049 1 -- Ptp10DNP5059 1 -- Ptp10D101 P-element activity 0 Yes Ptp10DBG01595 P-element activity 0 Yes Ptp10Dc05169 0 -- Ptp10DCC06344 P-element activity 0 Yes Ptp10Dchi hypomorphic allele - molecular evidence 0 Yes Ptp10Dd01869 P-element activity 0 -- Ptp10Dd09159 P-element activity 0 -- Ptp10DEP1332 hypomorphic allele - genetic evidence P-element activity 0 Yes Ptp10DEP1380 P-element activity 0 -- Ptp10Df07342 0 -- Ptp10DFB spontaneous 0 Yes Ptp10DGG01355 0 -- Ptp10DGG01648 0 -- Ptp10DGG01655 0 -- Ptp10DGG01826 0 -- Ptp10Dunspecified 0 --
Alleles Carried on Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ptp10D Class Mutagen Stocks Known lesion Ptp10DGD115 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes Ptp10DGD2611 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ptp10DHMS01917 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ptp10DCD.C1468S.MtnA.T:Hsap\MYC in vitro construct - amino acid replacement in vitro construct - site directed mutagenesis 0 Yes Ptp10DCD.MtnA.T:Hsap\MYC in vitro construct - regulatory fusion 0 Yes Ptp10DdsRNA.cMa in vitro construct - RNAi 0 Yes Ptp10DGD14490 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Ptp10Dhs.PQ in vitro construct - regulatory fusion 0 Yes Ptp10DKK101775 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Ptp10DMtnA.PF in vitro construct - regulatory fusion 0 Yes Ptp10DMtnA.T:Hsap\MYC,T:Myr-Src64B in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes Ptp10DNIG.1817R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Ptp10DScer\UAS.cQa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD115} NA P{GD2611} NA P{GD14490} NA P{KK101775} NA P{NIG.1817R} NA P{TRiP.HMS01917} NA P{UAS-Ptp10D.Q} NA heat-shock construct P{hs-Ptp10D.Q} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Ptp10DEP1172 NA P{EP}Ptp10DEP1332 NA P{EP}Ptp10DEP1380 NA P{Mae-UAS.6.11}Ptp10DGG01355 NA P{Mae-UAS.6.11}Ptp10DGG01648 NA P{Mae-UAS.6.11}Ptp10DGG01655 NA P{Mae-UAS.6.11}Ptp10DGG01826 NA P{XP}Ptp10Dd01321 NA P{XP}Ptp10Dd01869 NA P{XP}Ptp10Dd09159 NA miscellaneous insertions P{}Ptp10Dchi NA P{GT1}Ptp10DBG01595 NA P{GT1}Ptp10DBG02428 NA P{PTT-GC}Ptp10DCC06344 NA P{RS3}Ptp10DCB-5793-3 NA P{RS3}Ptp10DCB-6260-3 NA P{RS5}Ptp10D5-SZ-3438 NA PBac{PB}Ptp10Dc04386 NA PBac{PB}Ptp10Dc05169 NA PBac{RB}Ptp10De00662 NA PBac{WH}Ptp10Df00941 NA PBac{WH}Ptp10Df06456 NA PBac{WH}Ptp10Df06457 NA PBac{WH}Ptp10Df07342 NA insertion of enhancer trap binary system Mi{ET1}Ptp10DMB02913 No P{GawB}Ptp10DNP0438 No P{GawB}Ptp10DNP1049 No P{GawB}Ptp10DNP5059 No
Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
Terms Based on Experimental Evidence ( 9 terms )
Molecular Function
CV term Evidence References
phosphoprotein phosphatase activity inferred from direct assay (Muda et al., 2002) protein tyrosine phosphatase activity inferred from direct assay (Tian and Zinn, 1994)
Biological Process
CV term Evidence References
central nervous system development inferred from genetic interaction with Ptp4E (Jeon et al., 2008) long-term memory inferred from mutant phenotype (Qian et al., 2007) motor neuron axon guidance inferred from genetic interaction with Lar (Sun et al., 2001) inferred from genetic interaction with Lar, Ptp99A (Sun et al., 2001) inferred from genetic interaction with Ptp52F, Ptp4E (Jeon et al., 2008) inferred from genetic interaction with Ptp69D (Sun et al., 2001) inferred from genetic interaction with Ptp69D, Ptp4E (Jeon et al., 2008) open tracheal system development inferred from genetic interaction with Ptp4E (Jeon et al., 2008) protein dephosphorylation inferred from direct assay (Tian and Zinn, 1994) inferred from direct assay AND inferred from mutant phenotype (Muda et al., 2002)
Cellular Component
CV term Evidence References
apical part of cell inferred from direct assay (Jeon and Zinn, 2009) axon inferred from direct assay (Jeon et al., 2008)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
protein tyrosine phosphatase activity inferred from sequence or structural similarity with EMBL:X54131 (Tian et al., 1991) non-traceable author statement (Morrison et al., 2000) receptor signaling protein tyrosine phosphatase activity non-traceable author statement (Swiss-Prot Project Members, 2001.8.20) transmembrane receptor protein tyrosine phosphatase activity inferred from sequence or structural similarity (Yang et al., 1991) inferred from sequence or structural similarity with NCBI_gi:4506313 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 2001.8.20)
Biological Process
CV term Evidence References
protein dephosphorylation non-traceable author statement (Morrison et al., 2000)
Cellular Component
CV term Evidence References
plasma membrane inferred from sequence or structural similarity (Yang et al., 1991, Tian et al., 1991) non-traceable author statement (Swiss-Prot Project Members, 2001.8.20)
Sequence Ontology: Class of Gene
	gene_with_stop_codon_read_through (Jungreis et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ptp10D allele Gene References Ptp10D1 comm (Sun et al., 2000) Lar (Sun et al., 2000) Ptp52F (Schindelholz et al., 2001) Ptp69D (Sun et al., 2000) robo (Sun et al., 2000) sli (Sun et al., 2000) Ptp10D101 Ptp69D (Sun et al., 2000) Ptp10DEP1332 Ptp69D (Sun et al., 2000) unspecified Ptp99A (Sun et al., 2000)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58524 DroID - A comprehensive database of gene and protein interactions. • FBgn0004370 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32115
Orthologs
OrthoDB Orthologs (83) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG63BN75 Dipteran inclusive ortholog search EOG6RJG8H Insect inclusive ortholog search EOG68GTZ3 Arthropod inclusive ortholog search EOG6W0VV1 Metazoa inclusive ortholog search EOG60PH0H
Orthologs in Drosophila Species (EOG63BN75)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Ptp10D     Drosophila simulans   Dsim\Ptp10D Y   Drosophila sechellia   Dsec\GM13099 Y   Drosophila erecta   Dere\GG18436     Drosophila yakuba   Dyak\GE15658 Y   Drosophila ananassae   Dana\GF19443     Drosophila pseudoobscura pseudoobscura   Dpse\GA14821 Y   Drosophila persimilis   Dper\GL13109     Drosophila persimilis   Dper\GL13110     Drosophila willistoni   Dwil\GK25195 Y   Drosophila virilis   Dvir\GJ15918 Y   Drosophila mojavensis   Dmoj\GI16226     Drosophila grimshawi   Dgri\GH12596 Y
Orthologs in non-Drosophila Dipterans (EOG6RJG8H)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012083   Anopheles gambiae Malaria mosquito  Agam\AGAP004246   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006052
Orthologs in non-Dipteran Insects (EOG68GTZ3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB45612 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG009079 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17691 Y Atta cephalotes Leafcutter ant  Acep\ACEP10422 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO12701 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19813 Y Linepithema humile Argentine ant  Lhum\LH11081 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB20584 Y Solenopsis invicta Red fire ant  Sinv\SINV20739 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI006943 Y Bombyx mori Silkmoth  Bmor\BGIBMGA001079 Y Pediculus humanus Human body louse  Phum\PHUM530510 Y Tribolium castaneum Red flour beetle  Tcas\GLEAN_07672 Y
Orthologs in non-Insect Arthropods (EOG6W0VV1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_306015 Y Ixodes scapularis Deer tick  Isca\ISCW022067 Y
Orthologs in non-Arthropod Metazoa (EOG60PH0H)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\dep-1 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_011473gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_013800gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003659gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_023400gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_004193gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026676gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_005860gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026259gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018476gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024764gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015919gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_028717gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016937gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_011327gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_022616gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_001461gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002657gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018071gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002802gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_005060gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_021252gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003995gn Y Danio rerio Zebrafish  Drer\ptprh Y Danio rerio Zebrafish  Drer\ENSDARG00000016579 Y Danio rerio Zebrafish  Drer\ptprb Y Danio rerio Zebrafish  Drer\ptprja Y Danio rerio Zebrafish  Drer\si:dkey-197c15.4 Y Danio rerio Zebrafish  Drer\ENSDARG00000086511 Y Danio rerio Zebrafish  Drer\ptprjb Y Danio rerio Zebrafish  Drer\ptpro Y Xenopus tropicalis Western clawed frog  Xtro\ptprb Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000007735 Y Xenopus tropicalis Western clawed frog  Xtro\ptpro Y Xenopus tropicalis Western clawed frog  Xtro\ptprh Y Gallus gallus Domestic chicken  Ggal\PTPRB Y Gallus gallus Domestic chicken  Ggal\PTPRJ Y Gallus gallus Domestic chicken  Ggal\ENSGALG00000000584 Y Gallus gallus Domestic chicken  Ggal\PTPRO Y Mus musculus House mouse  Mmus\Ptprh Y Mus musculus House mouse  Mmus\Ptprj Y Mus musculus House mouse  Mmus\Ptpro Y Mus musculus House mouse  Mmus\Ptprb Y Rattus norvegicus Norway rat  Rnor\Ptprv Y Rattus norvegicus Norway rat  Rnor\Ptprb_predicted Y Rattus norvegicus Norway rat  Rnor\Ptprh Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000034025 Y Rattus norvegicus Norway rat  Rnor\Ptpro Y Homo sapiens Human  Hsap\PTPRO Y Homo sapiens Human  Hsap\PTPRJ Y Homo sapiens Human  Hsap\ENSG00000127329 Y Homo sapiens Human  Hsap\PTPRH Y
Human Orthologs (4)
Gene OMIM HGNC Hsap\PTPRO     Hsap\PTPRJ     Hsap\ENSG00000127329     Hsap\PTPRH
AAA Orthologs (7) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\Ptp10D Drosophila sechellia Dsec\GM13099 Drosophila yakuba Dyak\GE15658 Drosophila pseudoobscura pseudoobscura Dpse\GA14821 Drosophila willistoni Dwil\GK25195 Drosophila virilis Dvir\GJ15918 Drosophila grimshawi Dgri\GH12596
Stocks & Reagents
Stocks Listed in FlyBase ( 23 )
Bloomington	5810 w* Ptp10D1
Harvard	- P{XP}Ptp10Dd01321 - PBac{PB}Ptp10Dc04386 - PBac{RB}Ptp10De00662 - PBac{WH}Ptp10Df00941 - PBac{WH}Ptp10Df06456 - PBac{WH}Ptp10Df06457
Kyoto	108436 w* Ptp10D1/FM7c
VDRC	v1101 w1118; P{GD115}v1101 v1102 w1118; P{GD115}v1102 v8010 w1118; P{GD2611}v8010 v1104 w1118; P{GD115}v1104/TM3
	More stocks available...
Genomic Clones ( 2 )
	BACR26B05 BACR29A04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 66 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE52018
Other clones	RT11161
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH17637 LD44215 LP02455 RH13562 RH17963 RH49548 SD15221
Other clones	10105 33310 55834 58161 65484 79269 84035 125519 153558 214255.4 523437 bs61e03 CK01.18C.C6 CK01.33D.F11 CK01.60B.D5 CK01.79A.H2 CK01.96B.F5 CK01.97C.F12 CK01.107A.C11 CK01.120C.E12 CK01.132D.E3 CK01711 EK030118 EK061461 EK063415 EK075654 EK092039 EK101218 EK110245 EK133352 EK143348 EK180638 EK183914 EK191823 EK208911 EK218636 EK247610 EK257026 EK259607 EN01055 EN03922 EN04964 EN06105 EN06942 EN09564 RP003012287 RP003072729 RP003108449 RP003109889 RP003114819 RP003134819 RP003248375 RP003434849 RP003483728 RP003581189 RP004469429 RP004509921
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004370 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32115
Antibody Information
	monoclonal (Tian et al., 1991) polyclonal (Yang et al., 1991)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Ptp10D CG1817 (Wang, 1999.11)
Source for database merge of
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Ptp10D and Ptp69D are necessary for repulsion of growth cones from the midline of the embryonic central nervous system. (Sun et al., 2000) Ptp10D and shg form stable complexes in culture cells and in wild type larval tissue. Ptp10D cytoplasmic domain is sufficient to confer binding to shg. Results support the hypothesis that Ptp10D regulates shg signaling in vivo. (Fashena and Zinn, 1997) Spatial and temporal transcript accumulation pattern in ovaries is determined by in situ hybridisation. (Fitzpatrick et al., 1995) Transmembrane Gp150 glycoprotein selectively interacts with the active site of the catalytic domain of Ptp10D (interaction is blocked by mutation of the active site or by the inhibitor vanadate). Ptp10D may function in vivo to regulate phosphorylation of Gp150 thereby controlling interactions with downstream effectors. (Tian and Zinn, 1994) A 150kD transmembrane protein, Gp150, binds to the Ptp10D cytoplasmic domain. (Tian et al., 1993) Receptor linked PTPases may be involved in axon outgrowth and guidance during embryonic development. (Tian et al., 1991) Ptp10D has been characterised. Ptp10D transcripts and proteins are localised exclusively to the CNS, and expression coincides temporally with axon outgrowth. (Yang et al., 1991)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_167292 NM_206690 NM_206691 NM_001144715 NM_001272524 NM_001272525 RefSeq (Proteins) • NP_727544 NP_996413 NP_996414 NP_001138187 NP_001259453 NP_001259454 DDBJ / EMBL / GenBank • AAA28484 AAA28952 AAF48072 AAO42638 AAS65319 AAS65320 ACL82919 AGB95296 AGB95297 AJ569651 AJ569652 AJ569653 AJ569654 AJ569656 AJ569657 AJ569658 AJ569659 AJ569660 AJ569661 AJ569662 AJ569663 AJ569664 AJ569665 AJ569667 AJ569668 AJ569669 AJ569670 AJ569671 AJ569672 AJ569673 AJ569674 AJ569675 AJ569678 AJ569679 AJ569680 AJ569681 AJ569682 AJ569683 AJ569684 AJ569685 AJ569686 AJ569687 AJ569689 AJ569690 AJ569691 AJ569692 AJ569693 AJ569694 AJ569695 AJ569696 AJ569697 AJ569698 AJ569700 AJ569701 AJ569702 AJ569703 AJ889255 AJ889256 AJ889257 AJ889258 AJ889259 AJ889260 AJ889261 AJ889262 AJ889263 AJ889264 AJ889265 AJ889266 AJ889267 AJ889268 AJ889269 AJ889270 AJ889271 AJ889272 AJ889273 AJ889274 AJ889275 AJ889276 AJ889277 AJ889278 AJ889279 AJ889280 AJ889281 AJ889282 AJ889283 AJ889284 AJ889285 AJ889286 AJ889287 AJ889288 AJ889289 AJ889290 AJ889291 AJ889292 AJ889293 AJ889294 AJ889295 AJ889296 AJ889297 AJ889298 AJ889299 AQ025398 AQ025427 AQ073197 BH011504 BI366463 BT004474 CZ469214 CZ472158 CZ472484 CZ476591 CZ476592 CZ478522 CZ478523 CZ483420 CZ489162 M80465 M80538 Entrez Gene - A searchable database of RefSeq genes. • 32115 UniProtKB/Swiss-Prot • P35992
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein-tyrosine phosphatase, receptor/non-receptor type (IPR000242) Protein-tyrosine/Dual specificity phosphatase (IPR000387) Fibronectin, type III (IPR003961) Protein-tyrosine phosphatase, active site (IPR016130) Immunoglobulin-like fold (IPR013783)
Linkouts
	BioGRID - A database of protein and genetic interactions • 58524 DroID - A comprehensive database of gene and protein interactions. • FBgn0004370 DRSC - Results from RNAi screens. • FBgn0004370 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004370 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1817-RB;CG1817-RC FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004370 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32115 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/ptp4e&ptp10d.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32115 modMine - Data generated by the modENCODE project. • FBgn0004370
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	CG1817 (Norga et al., 2003, Kraut et al., 2001, Kraut et al., 2001, Morrison et al., 2000, Schiess et al., 2009, Keleman et al., 2009.8.5, Ni et al., 2010.12.1) CT4920 (Hynes and Zhao, 2000) DPTP (Walchli et al., 2000) dptp (Babu et al., 2005) DPTP10D (Fox and Zinn, 2005, Ensslen-Craig and Brady-Kalnay, 2004, Muda et al., 2002, Schindelholz et al., 2001, Stoker, 2001, Walchli et al., 2000, Sun et al., 2000, den Hertog, 1999, Wills et al., 1999, Stoker and Dutta, 1998, Van Vactor, 1998, Van Vactor et al., 1998, Brady-Klanay and Tonks, 1994, Fashena and Zinn, 1997, Bahri et al., 1997, Sun et al., 1997, Chien, 1996, Fitzpatrick et al., 1995, Desai et al., 1995, Yang et al., 1991, Tian et al., 1993, Bahri and Chia, 1994, Desai et al., 1994, Tian and Zinn, 1994, Oon et al., 1993, Tian et al., 1991, Yang et al., 1991, Sun et al., 2001, Raghava et al., 2008, Quinones et al., 2010, Madan and Gopal, 2008) DPTP10D (Tian et al., 1991) Ptp10 (McGovern and Seeger, 2001) ptp10D (Hu, 2005) PTP10D (Rao et al., 2002, Koushika et al., 2000, Qian et al., 2007, Hofmeyer and Treisman, 2009, Madan and Gopal, 2011) Ptp10D (Altenhein et al., 2006, Badal et al., 2006, Jeon et al., 2008, Buszczak et al., 2007, Bugga et al., 2009, Jungreis et al., 2011, Jeon and Zinn, 2009, Sun et al., 2001, Wright et al., 2010, Wasbrough et al., 2010, Japanese National Institute of Genetics, 2012.5.21) R-PTP 10D (Morrison et al., 2000)
Name Synonym	Protein tyrosine phosphatase 10B (Siddiqui et al., 2012) Protein tyrosine phosphatase 10D
Secondary FlyBase IDs
	FBgn0019946
References ( 89 )
Generate a list of	All references relating to this gene ( 89 )
List References by type	Research paper  ( 38 ) Supplementary material  ( 13 ) Review  ( 10 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 11 ) FlyBase analysis  ( 2 ) Stock list  ( 1 ) Curated genome annotation  ( 2 ) Protein sequence record  ( 1 ) DNA/RNA sequence record  ( 1 )
Recent research papers ( 4 )
	Siddiqui et al., 2012, Genome Biol. 13(2): R11 Genome-wide analysis of the maternal-to-zygotic transition in Drosophila primordial germ cells. [FBrf0218847] Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Horn et al., 2011, Nat. Methods 8(4): 341--346 Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. [FBrf0213352] Madan and Gopal, 2011, Biochemistry 50(46): 10114--10125 Conformational Basis for Substrate Recruitment in Protein Tyrosine Phosphatase 10D. [FBrf0216622] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...