KLP38B, tio, 38B.12, 38B.10, Mothra
Gene model reviewed during 5.43
Gene model reviewed during 5.52
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\neb using the Feature Mapper tool.
neb is expressed in proliferating cells in various tissues and developmental stages, including the central nervous system, imaginal discs, testis, and ovary.
The neb transcript is most abundant in 0-2 hr embryos, and is also present in later embryos and in adults. In situ analysis shows that neb is distributed uniformly in preblastoderm embryos. neb is restricted to the nervous system at mid-embryogenesis, and is found in the procephalic neuroblasts and the ventral cord late in embryogenesis. During larval stages, expression is detected in the mitotically active regions of the brain and imaginal discs. From stage 5 of oogenesis, neb is detected in follicle cells and nurse cells. In th adult testis, neb accumulates in gonial cells and in primary spermatocytes.
GBrowse - Visual display of RNA-Seq signalsView Dmel\neb in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
neb, perhaps redundantly with other chromosome-associated microtubule motor proteins, contributes to interactions between chromosome arms and microtubules important for establishing bipolar attachment of chromosomes and assembly of stable bipolar spindles.
neb is required during mitosis for chromosome placement or maintenance at the metaphase plate in blastoderm embryos.
The neb protein functions during meiosis, mitosis and abdominal segmentation. Mutant phenotypes suggests that neb encodes a chromokinesin that provides astral exclusion forces on the chromosomes during meiosis and mitosis, and might be involved in polar granule formation.
Encodes a kinesin-like protein.