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Gene Dmel\Klp98A

General Information
Symbol	Dmel\Klp98A	Species	D. melanogaster
Name	Kinesin-like protein at 98A	Annotation symbol	CG5658
Feature type	protein_coding_gene	FlyBase ID	FBgn0004387
Gene Model Status	Current	Stock availability	9 publicly available
Also Known As	DmKlp98A
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	98A4-98A6	Sequence location	3R:23,373,497..23,384,867 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Kinesin-like protein at 98A is referred to in FlyBase by the symbol Dmel\Klp98A (CG5658, FBgn0004387). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: microtubule motor activity. Based on sequence similarity, it is predicted to be involved in the biological process: microtubule-based movement. 10 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Forkhead-associated (FHA) domain; Kinesin, motor domain; Kinesin, motor region, conserved site; Phox homologous domain; SMAD/FHA domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1634306_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Klp98A. Gene sequence location is 3R:23373497..23384867.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 98A4-98A6   Limits computationally determined from genome sequence between P{PZ}sda03884 and P{PZ}btzrL203
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Klp98A for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Klp98A-RA FBtr0085211  NM_079808   5530   1265 Klp98A-RB FBtr0304671  NM_001260410   5407   1224
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Klp98A-PA   FBpp0084581   141.6   1265   6.03     NP_524532   AAF56718 Klp98A-PB   FBpp0293213   136.8   1224   6.20     NP_001247339   AFH06656
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Forkhead-associated (FHA) domain (IPR000253) Phox homologous domain (IPR001683) Kinesin, motor domain (IPR001752) SMAD/FHA domain (IPR008984) Kinesin, motor region, conserved site (IPR019821) P-loop containing nucleoside triphosphate hydrolase (IPR027417)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA952077   AE014297 AAF56718   AE014297 AFH06656   AW942933   AY070884 AAL48506   BF498281   BP540296   BT132947   CO184426   CO188978   CO276687   CO281837   CO283166   CO302882   CO311685   CO326054   CO329880   CO330552   CO342900   CZ470169   CZ470170   CZ478344   CZ487163   EC062327   EC067390   EC072232   EC080671   EC083062   EC085269   EC202321   EC216337   EC217808   EC236520   EC260067   EC260538   ES688619   EV580172   EV600075   M74432 AAA28659
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VB25 Q8SZH6 Q00088
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    176.375 Larval Midgut    134.9 Larval Hindgut    200.1 Larval Malpighian Tubules    369.6 Larval Fat Body    190.2 Larval Salivary Gland    187.5 Larval Trachea    164.65 Larval Carcass    239.6 Adult Head    162.7 Adult Eye    252.125 Adult Brain    271.5 Adult Thoracic-Abdominal Ganglion    180.4 Adult Crop    249.4 Adult Midgut    78.5 Adult Hindgut    185.7 Adult Malpighian Tubules    323.8 Adult Fat Body    187.2 Adult Salivary Gland    224.7 Adult Heart    408.5 Adult VirginFemale Spermatheca    227.7 Adult InseminatedFemale Spermatheca    204 Adult Ovary    168.3 Adult Testis    12.3 Adult Male Accessory Gland    105 Adult Carcass    107.1 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    176.375 Larval Midgut    134.9 Larval Hindgut    200.1 Larval Malpighian Tubules    369.6 Larval Fat Body    190.2 Larval Salivary Gland    187.5 Larval Trachea    164.65 Larval Carcass    239.6 Adult Head    162.7 Adult Eye    252.125 Adult Brain    271.5 Adult Thoracic-Abdominal Ganglion    180.4 Adult Crop    249.4 Adult Midgut    78.5 Adult Hindgut    185.7 Adult Malpighian Tubules    323.8 Adult Fat Body    187.2 Adult Salivary Gland    224.7 Adult Heart    408.5 Adult VirginFemale Spermatheca    227.7 Adult InseminatedFemale Spermatheca    204 Adult Ovary    168.3 Adult Testis    12.3 Adult Male Accessory Gland    105 Adult Carcass    107.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    176.375 Larval Midgut    134.9 Larval Hindgut    200.1 Larval Malpighian Tubules    369.6 Larval Fat Body    190.2 Larval Salivary Gland    187.5 Larval Trachea    164.65 Larval Carcass    239.6 Adult Head    162.7 Adult Eye    252.125 Adult Brain    271.5 Adult Thoracic-Abdominal Ganglion    180.4 Adult Crop    249.4 Adult Midgut    78.5 Adult Hindgut    185.7 Adult Malpighian Tubules    323.8 Adult Fat Body    187.2 Adult Salivary Gland    224.7 Adult Heart    408.5 Adult VirginFemale Spermatheca    227.7 Adult InseminatedFemale Spermatheca    204 Adult Ovary    168.3 Adult Testis    12.3 Adult Male Accessory Gland    105 Adult Carcass    107.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    176.375 Larval Midgut    134.9 Larval Hindgut    200.1 Larval Malpighian Tubules    369.6 Larval Fat Body    190.2 Larval Salivary Gland    187.5 Larval Trachea    164.65 Larval Carcass    239.6 Adult Head    162.7 Adult Eye    252.125 Adult Brain    271.5 Adult Thoracic-Abdominal Ganglion    180.4 Adult Crop    249.4 Adult Midgut    78.5 Adult Hindgut    185.7 Adult Malpighian Tubules    323.8 Adult Fat Body    187.2 Adult Salivary Gland    224.7 Adult Heart    408.5 Adult VirginFemale Spermatheca    227.7 Adult InseminatedFemale Spermatheca    204 Adult Ovary    168.3 Adult Testis    12.3 Adult Male Accessory Gland    105 Adult Carcass    107.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    176.375 Larval Midgut    134.9 Larval Hindgut    200.1 Larval Malpighian Tubules    369.6 Larval Fat Body    190.2 Larval Salivary Gland    187.5 Larval Trachea    164.65 Larval Carcass    239.6 Adult Head    162.7 Adult Eye    252.125 Adult Brain    271.5 Adult Thoracic-Abdominal Ganglion    180.4 Adult Crop    249.4 Adult Midgut    78.5 Adult Hindgut    185.7 Adult Malpighian Tubules    323.8 Adult Fat Body    187.2 Adult Salivary Gland    224.7 Adult Heart    408.5 Adult VirginFemale Spermatheca    227.7 Adult InseminatedFemale Spermatheca    204 Adult Ovary    168.3 Adult Testis    12.3 Adult Male Accessory Gland    105 Adult Carcass    107.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    176.375 Larval Midgut    134.9 Larval Hindgut    200.1 Larval Malpighian Tubules    369.6 Larval Fat Body    190.2 Larval Salivary Gland    187.5 Larval Trachea    164.65 Larval Carcass    239.6 Adult Head    162.7 Adult Eye    252.125 Adult Brain    271.5 Adult Thoracic-Abdominal Ganglion    180.4 Adult Crop    249.4 Adult Midgut    78.5 Adult Hindgut    185.7 Adult Malpighian Tubules    323.8 Adult Fat Body    187.2 Adult Salivary Gland    224.7 Adult Heart    408.5 Adult VirginFemale Spermatheca    227.7 Adult InseminatedFemale Spermatheca    204 Adult Ovary    168.3 Adult Testis    12.3 Adult Male Accessory Gland    105 Adult Carcass    107.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    176.375 Larval Midgut    134.9 Larval Hindgut    200.1 Larval Malpighian Tubules    369.6 Larval Fat Body    190.2 Larval Salivary Gland    187.5 Larval Trachea    164.65 Larval Carcass    239.6 Adult Head    162.7 Adult Eye    252.125 Adult Brain    271.5 Adult Thoracic-Abdominal Ganglion    180.4 Adult Crop    249.4 Adult Midgut    78.5 Adult Hindgut    185.7 Adult Malpighian Tubules    323.8 Adult Fat Body    187.2 Adult Salivary Gland    224.7 Adult Heart    408.5 Adult VirginFemale Spermatheca    227.7 Adult InseminatedFemale Spermatheca    204 Adult Ovary    168.3 Adult Testis    12.3 Adult Male Accessory Gland    105 Adult Carcass    107.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    176.375 Larval Midgut    134.9 Larval Hindgut    200.1 Larval Malpighian Tubules    369.6 Larval Fat Body    190.2 Larval Salivary Gland    187.5 Larval Trachea    164.65 Larval Carcass    239.6 Adult Head    162.7 Adult Eye    252.125 Adult Brain    271.5 Adult Thoracic-Abdominal Ganglion    180.4 Adult Crop    249.4 Adult Midgut    78.5 Adult Hindgut    185.7 Adult Malpighian Tubules    323.8 Adult Fat Body    187.2 Adult Salivary Gland    224.7 Adult Heart    408.5 Adult VirginFemale Spermatheca    227.7 Adult InseminatedFemale Spermatheca    204 Adult Ovary    168.3 Adult Testis    12.3 Adult Male Accessory Gland    105 Adult Carcass    107.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    162.7   NA  Eye    252.125   NA  Brain    271.5   176.375  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    180.4   NA  Crop    249.4   134.9  Midgut    78.5   200.1  Hindgut    185.7   369.6  Malpighian Tubules    323.8   190.2  Fat Body    187.2   187.5  Salivary Gland    224.7   NA  Heart    408.5   164.65  Trachea    NA   NA  VirginFemale Spermatheca    227.7   NA  InseminatedFemale Spermatheca    204   NA  Ovary    168.3   NA  Testis    12.3   NA  Male Accessory Gland    105   239.6  Carcass    107.1 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    10 central nervous system, pupae P8    12 head, virgin 1-day female    13 head, virgin 4-day female    11 head, virgin 20-day female    10 head, mated 1-day female    10 head, mated 4-day female    11 head, mated 20-day female    10 head, mated 1-day male    17 head, mated 4-day male    14 head, mated 20-day male    19 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    5 fat body, white prepupae    18 fat body, pupae P8    11 carcass, larvae L3 wandering    20 carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    27 ovary, mated 4-day female    21 testis, mated 4-day male    17 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    10 central nervous system, pupae P8    12 head, virgin 1-day female    13 head, virgin 4-day female    11 head, virgin 20-day female    10 head, mated 1-day female    10 head, mated 4-day female    11 head, mated 20-day female    10 head, mated 1-day male    17 head, mated 4-day male    14 head, mated 20-day male    19 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    5 fat body, white prepupae    18 fat body, pupae P8    11 carcass, larvae L3 wandering    20 carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female  (27) ovary, mated 4-day female    21 testis, mated 4-day male    17 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    10 central nervous system, pupae P8    12 head, virgin 1-day female    13 head, virgin 4-day female    11 head, virgin 20-day female    10 head, mated 1-day female    10 head, mated 4-day female    11 head, mated 20-day female    10 head, mated 1-day male    17 head, mated 4-day male    14 head, mated 20-day male    19 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    5 fat body, white prepupae    18 fat body, pupae P8    11 carcass, larvae L3 wandering    20 carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    27 ovary, mated 4-day female    21 testis, mated 4-day male    17 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    10 central nervous system, pupae P8    12 head, virgin 1-day female    13 head, virgin 4-day female    11 head, virgin 20-day female    10 head, mated 1-day female    10 head, mated 4-day female    11 head, mated 20-day female    10 head, mated 1-day male    17 head, mated 4-day male    14 head, mated 20-day male    19 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    5 fat body, white prepupae    18 fat body, pupae P8    11 carcass, larvae L3 wandering    20 carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    27 ovary, mated 4-day female    21 testis, mated 4-day male    17 accessory gland, mated 4-day male    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    10 central nervous system, pupae P8    12 head, virgin 1-day female    13 head, virgin 4-day female    11 head, virgin 20-day female    10 head, mated 1-day female    10 head, mated 4-day female    11 head, mated 20-day female    10 head, mated 1-day male    17 head, mated 4-day male    14 head, mated 20-day male    19 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    5 fat body, white prepupae    18 fat body, pupae P8    11 carcass, larvae L3 wandering    20 carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    27 ovary, mated 4-day female    21 testis, mated 4-day male    17 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    10 central nervous system, pupae P8    12 head, virgin 1-day female    13 head, virgin 4-day female    11 head, virgin 20-day female    10 head, mated 1-day female    10 head, mated 4-day female    11 head, mated 20-day female    10 head, mated 1-day male    17 head, mated 4-day male    14 head, mated 20-day male    19 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    5 fat body, white prepupae    18 fat body, pupae P8    11 carcass, larvae L3 wandering    20 carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female  27 ovary, mated 4-day female    21 testis, mated 4-day male    17 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    10 central nervous system, pupae P8    12 head, virgin 1-day female    13 head, virgin 4-day female    11 head, virgin 20-day female    10 head, mated 1-day female    10 head, mated 4-day female    11 head, mated 20-day female    10 head, mated 1-day male    17 head, mated 4-day male    14 head, mated 20-day male    19 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    5 fat body, white prepupae    18 fat body, pupae P8    11 carcass, larvae L3 wandering    20 carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    27 ovary, mated 4-day female    21 testis, mated 4-day male    17 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    10 central nervous system, pupae P8    12 head, virgin 1-day female    13 head, virgin 4-day female    11 head, virgin 20-day female    10 head, mated 1-day female    10 head, mated 4-day female    11 head, mated 20-day female    10 head, mated 1-day male    17 head, mated 4-day male    14 head, mated 20-day male    19 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    5 fat body, white prepupae    18 fat body, pupae P8    11 carcass, larvae L3 wandering    20 carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    27 ovary, mated 4-day female    21 testis, mated 4-day male    17 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    12 embryo 04-06hr    13 embryo 06-08hr    22 embryo 08-10hr    26 embryo 10-12hr    30 embryo 12-14hr    23 embryo 14-16hr    20 embryo 16-18hr    17 embryo 18-20hr    15 embryo 20-22hr    11 embryo 22-24hr    13 larva L1    10 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    22 white prepupae new    25 white prepupae 12hr    14 white prepupae 24hr    20 pupae 2d postWPP    16 pupae 3d postWPP    13 pupae 4d postWPP    10 adult male 01day    14 adult male 05day    14 adult male 30day    16 adult female 01day    15 adult female 05day    17 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (28) embryo 02-04hr    12 embryo 04-06hr    13 embryo 06-08hr    22 embryo 08-10hr  26 embryo 10-12hr  (30) embryo 12-14hr    23 embryo 14-16hr    20 embryo 16-18hr    17 embryo 18-20hr    15 embryo 20-22hr    11 embryo 22-24hr    13 larva L1    10 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    22 white prepupae new    25 white prepupae 12hr    14 white prepupae 24hr    20 pupae 2d postWPP    16 pupae 3d postWPP    13 pupae 4d postWPP    10 adult male 01day    14 adult male 05day    14 adult male 30day    16 adult female 01day    15 adult female 05day    17 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    12 embryo 04-06hr    13 embryo 06-08hr    22 embryo 08-10hr    26 embryo 10-12hr    30 embryo 12-14hr    23 embryo 14-16hr    20 embryo 16-18hr    17 embryo 18-20hr    15 embryo 20-22hr    11 embryo 22-24hr    13 larva L1    10 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    22 white prepupae new    25 white prepupae 12hr    14 white prepupae 24hr    20 pupae 2d postWPP    16 pupae 3d postWPP    13 pupae 4d postWPP    10 adult male 01day    14 adult male 05day    14 adult male 30day    16 adult female 01day    15 adult female 05day    17 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    12 embryo 04-06hr    13 embryo 06-08hr    22 embryo 08-10hr    26 embryo 10-12hr    30 embryo 12-14hr    23 embryo 14-16hr    20 embryo 16-18hr    17 embryo 18-20hr    15 embryo 20-22hr    11 embryo 22-24hr    13 larva L1    10 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    22 white prepupae new    25 white prepupae 12hr    14 white prepupae 24hr    20 pupae 2d postWPP    16 pupae 3d postWPP    13 pupae 4d postWPP    10 adult male 01day    14 adult male 05day    14 adult male 30day    16 adult female 01day    15 adult female 05day    17 adult female 30day    17 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    12 embryo 04-06hr    13 embryo 06-08hr    22 embryo 08-10hr    26 embryo 10-12hr    30 embryo 12-14hr    23 embryo 14-16hr    20 embryo 16-18hr    17 embryo 18-20hr    15 embryo 20-22hr    11 embryo 22-24hr    13 larva L1    10 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    22 white prepupae new    25 white prepupae 12hr    14 white prepupae 24hr    20 pupae 2d postWPP    16 pupae 3d postWPP    13 pupae 4d postWPP    10 adult male 01day    14 adult male 05day    14 adult male 30day    16 adult female 01day    15 adult female 05day    17 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  28 embryo 02-04hr    12 embryo 04-06hr    13 embryo 06-08hr    22 embryo 08-10hr  26 embryo 10-12hr  30 embryo 12-14hr    23 embryo 14-16hr    20 embryo 16-18hr    17 embryo 18-20hr    15 embryo 20-22hr    11 embryo 22-24hr    13 larva L1    10 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    22 white prepupae new    25 white prepupae 12hr    14 white prepupae 24hr    20 pupae 2d postWPP    16 pupae 3d postWPP    13 pupae 4d postWPP    10 adult male 01day    14 adult male 05day    14 adult male 30day    16 adult female 01day    15 adult female 05day    17 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    12 embryo 04-06hr    13 embryo 06-08hr    22 embryo 08-10hr    26 embryo 10-12hr    30 embryo 12-14hr    23 embryo 14-16hr    20 embryo 16-18hr    17 embryo 18-20hr    15 embryo 20-22hr    11 embryo 22-24hr    13 larva L1    10 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    22 white prepupae new    25 white prepupae 12hr    14 white prepupae 24hr    20 pupae 2d postWPP    16 pupae 3d postWPP    13 pupae 4d postWPP    10 adult male 01day    14 adult male 05day    14 adult male 30day    16 adult female 01day    15 adult female 05day    17 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    12 embryo 04-06hr    13 embryo 06-08hr    22 embryo 08-10hr    26 embryo 10-12hr    30 embryo 12-14hr    23 embryo 14-16hr    20 embryo 16-18hr    17 embryo 18-20hr    15 embryo 20-22hr    11 embryo 22-24hr    13 larva L1    10 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    22 white prepupae new    25 white prepupae 12hr    14 white prepupae 24hr    20 pupae 2d postWPP    16 pupae 3d postWPP    13 pupae 4d postWPP    10 adult male 01day    14 adult male 05day    14 adult male 30day    16 adult female 01day    15 adult female 05day    17 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    29 Schneider line 2 Sg4    13 embryonic 1182-4H    18 embryonic GM2    21 embryonic Kc167    18 embryonic S1    14 embryonic S3    10 leg disc CME L1    14 wing disc CME-W2    12 wing disc ML-DmD8    7 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    11 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    26 ovary fGS/OSS    29 ovary OSC    12 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (29) Schneider line 2 Sg4    13 embryonic 1182-4H    18 embryonic GM2    21 embryonic Kc167    18 embryonic S1    14 embryonic S3    10 leg disc CME L1    14 wing disc CME-W2    12 wing disc ML-DmD8    7 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    11 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2  26 ovary fGS/OSS  (29) ovary OSC    12 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    29 Schneider line 2 Sg4    13 embryonic 1182-4H    18 embryonic GM2    21 embryonic Kc167    18 embryonic S1    14 embryonic S3    10 leg disc CME L1    14 wing disc CME-W2    12 wing disc ML-DmD8    7 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    11 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    26 ovary fGS/OSS    29 ovary OSC    12 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    29 Schneider line 2 Sg4    13 embryonic 1182-4H    18 embryonic GM2    21 embryonic Kc167    18 embryonic S1    14 embryonic S3    10 leg disc CME L1    14 wing disc CME-W2    12 wing disc ML-DmD8    7 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    11 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    26 ovary fGS/OSS    29 ovary OSC    12 ovary OSS    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    29 Schneider line 2 Sg4    13 embryonic 1182-4H    18 embryonic GM2    21 embryonic Kc167    18 embryonic S1    14 embryonic S3    10 leg disc CME L1    14 wing disc CME-W2    12 wing disc ML-DmD8    7 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    11 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    26 ovary fGS/OSS    29 ovary OSC    12 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  29 Schneider line 2 Sg4    13 embryonic 1182-4H    18 embryonic GM2    21 embryonic Kc167    18 embryonic S1    14 embryonic S3    10 leg disc CME L1    14 wing disc CME-W2    12 wing disc ML-DmD8    7 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    11 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2  26 ovary fGS/OSS  29 ovary OSC    12 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    29 Schneider line 2 Sg4    13 embryonic 1182-4H    18 embryonic GM2    21 embryonic Kc167    18 embryonic S1    14 embryonic S3    10 leg disc CME L1    14 wing disc CME-W2    12 wing disc ML-DmD8    7 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    11 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    26 ovary fGS/OSS    29 ovary OSC    12 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    29 Schneider line 2 Sg4    13 embryonic 1182-4H    18 embryonic GM2    21 embryonic Kc167    18 embryonic S1    14 embryonic S3    10 leg disc CME L1    14 wing disc CME-W2    12 wing disc ML-DmD8    7 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    11 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    26 ovary fGS/OSS    29 ovary OSC    12 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_27 mE1_20_mRNA_expression_cluster_09
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004387 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5658-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Klp98AGD11724 Phenotype manifest in Allele
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of Klp98A Class Mutagen Stocks Known lesion Klp98Ac05668 piggyBac transposase 1 -- Klp98Ae00454 piggyBac transposase 1 -- Klp98Af04624 piggyBac transposase 1 -- Klp98AMI01231 1 -- Klp98ANP6659 1 -- Klp98ADG30506 P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Klp98A Class Mutagen Stocks Known lesion Klp98AGD11724 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Klp98AHMS01957 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Klp98AUbi-p63E.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 1 Yes Klp98AdsRNA.cGa in vitro construct - RNAi 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11724} NA P{TRiP.HMS01957} NA characterization construct P{Ubi-p63E-Klp98A.Myc} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}Klp98AMI01231 NA P{wHy}Klp98ADG30506 NA PBac{PB}Klp98Ac05668 NA PBac{RB}Klp98Ae00454 NA PBac{WH}Klp98Af04624 NA insertion of enhancer trap binary system P{GawB}Klp98ANP6659 No
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR001752, InterPro:IPR019821 (FlyBase Curators et al., 2004-) microtubule motor activity inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) inferred from sequence or structural similarity with UniProtKB:O43896 (FlyBase, 1992-) phosphatidylinositol binding inferred from electronic annotation with InterPro:IPR001683 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
cell communication inferred from electronic annotation with InterPro:IPR001683 (FlyBase Curators et al., 2004-) microtubule-based movement inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) inferred from sequence or structural similarity with UniProtKB:O43896 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
kinesin complex inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) inferred from sequence or structural similarity with UniProtKB:O43896 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Klp98A allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68194 DroID - A comprehensive database of gene and protein interactions. • FBgn0004387 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43310 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q8SZH6
Orthologs
OrthoDB Orthologs (36) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6SN271 Dipteran inclusive ortholog search EOG65B1PH Insect inclusive ortholog search EOG6CRJTX Arthropod inclusive ortholog search EOG6BNZSM Metazoa inclusive ortholog search EOG6677CP
Orthologs in Drosophila Species (EOG6SN271)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Klp98A     Drosophila simulans   Dsim\GD18075 Y   Drosophila sechellia   Dsec\GM16340 Y   Drosophila erecta   Dere\GG12110 Y   Drosophila yakuba   Dyak\GE10559 Y   Drosophila ananassae   Dana\GF18707 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19039 Y   Drosophila persimilis   Dper\GL23583 Y   Drosophila willistoni   Dwil\GK11333 Y   Drosophila virilis   Dvir\GJ22626 Y   Drosophila mojavensis   Dmoj\GI24560 Y   Drosophila grimshawi   Dgri\GH23772 Y
Orthologs in non-Drosophila Dipterans (EOG65B1PH)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL002987   Anopheles gambiae Malaria mosquito  Agam\AGAP003925   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ001696
Orthologs in non-Dipteran Insects (EOG6CRJTX)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB42066   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG013025   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH24644   Atta cephalotes Leafcutter ant  Acep\ACEP19323   Camponotus floridanus Florida carpenter ant  Cflo\CFLO12963   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21627   Linepithema humile Argentine ant  Lhum\LH12146   Pogonomyrmex barbatus Red harvester ant  Pbar\PB20703   Bombyx mori Silkmoth  Bmor\BGIBMGA000816   Tribolium castaneum Red flour beetle  Tcas\TC008919
Orthologs in non-Insect Arthropods (EOG6BNZSM)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Ixodes scapularis Deer tick  Isca\ISCW020500
Orthologs in non-Arthropod Metazoa (EOG6677CP)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026237gn   Danio rerio Zebrafish  Drer\si:dkey-210m15.4   Danio rerio Zebrafish  Drer\si:dkey-38k3.2   Xenopus tropicalis Western clawed frog  Xtro\stard9   Xenopus tropicalis Western clawed frog  Xtro\kif16b   Gallus gallus Domestic chicken  Ggal\STARD9   Gallus gallus Domestic chicken  Ggal\C20orf23   Mus musculus House mouse  Mmus\Kif16b   Rattus norvegicus Norway rat  Rnor\Kif16b   Homo sapiens Human  Hsap\KIF16B
Human Orthologs (1)
Gene OMIM HGNC Hsap\KIF16B
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD18075 Drosophila sechellia Dsec\GM16340 Drosophila erecta Dere\GG12110 Drosophila yakuba Dyak\GE10559 Drosophila ananassae Dana\GF18707 Drosophila pseudoobscura pseudoobscura Dpse\GA19039 Drosophila persimilis Dper\GL23583 Drosophila willistoni Dwil\GK11333 Drosophila virilis Dvir\GJ22626 Drosophila mojavensis Dmoj\GI24560 Drosophila grimshawi Dgri\GH23772
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	32833 P{Ubi-p63E-Klp98A.Myc}1, w* 34410 y1 w*; Mi{MIC}Klp98AMI01231 39037 y1 sc* v1; P{TRiP.HMS01957}attP40
Harvard	- PBac{PB}Klp98Ac05668 - PBac{RB}Klp98Ae00454 - PBac{WH}Klp98Af04624
Kyoto	105314 y* w*; P{GawB}Klp98ANP6659 / TM6, P{UAS-lacZ.UW23-1}UW23-1
VDRC	v40603 w1118; P{GD11724}v40603 v40605 w1118; P{GD11724}v40605/TM3
Genomic Clones ( 1 )
	BACR15D01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 29 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD29123
Other clones	FI17842
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT12665
Other clones	480 21106 51594 97674 102702 191347 192884 214349.15 214373.22 CK01.28D.D3 CK01.49A.B10 Dmel_dig_006554_0682_0312 Dmel_neb_012575_0860_0465 EC28075 EK042639 EK121837 EK158915 EK162416 EK185101 EK225861 EK294062 EK295536 EP03147 EP15714 FGA002A05 RC0-DA0001-120700-016-D05
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004387 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43310
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Klp98A has a specialised role in differentiation and may function in the transport of growth factors such as the wg protein. (Dalby et al., 1995) Klp98A has been cloned, partially sequenced and its expression pattern analysed. (Stewart et al., 1991)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079808 NM_001260410 RefSeq (Proteins) • NP_524532 NP_001247339 DDBJ / EMBL / GenBank • AA952077 AAA28659 AAF56718 AAL48506 AFH06656 AW942933 AY070884 CZ470169 CZ470170 CZ478344 CZ487163 M74432 Entrez Gene - A searchable database of RefSeq genes. • 43310 UniProtKB/TrEMBL • Q8SZH6 Q9VB25 Q00088
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Forkhead-associated (FHA) domain (IPR000253) Phox homologous domain (IPR001683) Kinesin, motor domain (IPR001752) SMAD/FHA domain (IPR008984) Kinesin, motor region, conserved site (IPR019821) P-loop containing nucleoside triphosphate hydrolase (IPR027417)
Linkouts
	BioGRID - A database of protein and genetic interactions • 68194 DroID - A comprehensive database of gene and protein interactions. • FBgn0004387 DRSC - Results from RNAi screens. • FBgn0004387 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004387 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5658-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004387 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43310 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43310 modMine - Data generated by the modENCODE project. • FBgn0004387 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q8SZH6
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG5658 (Goldstein and Gunawardena, 2000, Philipps et al., 2004, Ni et al., 2010.12.1) DmKlp98A (Kim and Endow, 2000, Dagenbach and Endow, 2004, Hirokawa, 2012) KIF 16A (Miki et al., 2001) KIF16A/B (Hirokawa, 2012.11.20) KLP6 (Stewart et al., 1991) Klp6   KLP98A (Dalby et al., 1994, Miki et al., 2005) Klp98A (Philipps et al., 2004, Goldstein, 2010.12.10, Miki et al., 2001, Hirokawa, 2012.11.20) Klp98a (Miki et al., 2001)
Name Synonym	Kinesin-like protein at 98A (Hirokawa, 2012.11.20)
Secondary FlyBase IDs
References ( 36 )
Generate a list of	All references relating to this gene ( 36 )
List References by type	Research paper  ( 6 ) Supplementary material  ( 5 ) Review  ( 4 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 4 ) FlyBase analysis  ( 2 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...