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Gene Dmel\pdm2

General Information
Symbol	Dmel\pdm2	Species	D. melanogaster
Name	POU domain protein 2	Annotation symbol	CG12287
Feature type	protein_coding_gene	FlyBase ID	FBgn0004394
Gene Model Status	Current	Stock availability	11 publicly available
Also Known As	pdm-2, pdm, miti, dPOU28, dPOU28/pdm-2, dPOU-28
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	33F2-33F3	Sequence location	2L:12,657,829..12,686,313 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene POU domain protein 2 is referred to in FlyBase by the symbol Dmel\pdm2 (CG12287, FBgn0004394). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription. There is experimental evidence that it is involved in the biological process: neuroblast development. 20 alleles are reported. The phenotypes of these alleles are annotated with: larval abdominal segment; organ system subdivision; nervous system; peripheral nervous system; embryonic/larval neuron; multicellular structure; somatic cell; organ system; embryonic abdomen; neuroblast NB4-2; ganglion mother cell GMC4-2a. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Homeobox; Homeobox, conserved site; Homeodomain-like; Homeodomain-related; Lambda repressor-like, DNA-binding; POU; POU-specific. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1624491_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of pdm2. Gene sequence location is 2L:12657829..12686313.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Nakajima et al., 2010, PLoS Comput. Biol. 6(4): e1000760
FB2012_01	Controlled Vocabulary Terms RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Insertions Mi{MIC}pdm2[MI03610] Alleles pdm2[MI03610] Sequence features HFA03587 BKN30854 HFA02496 HFA02497 References Kazemian et al., 2010, PLoS Biol. 8(8): Mace et al., 2010, Bioinformatics 26(6): 761--769 Bellen, 2011.10.25, set956.xml
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 33F2-33F3   Limits computationally determined from genome sequence between P{lacW}bunk00612&P{EP}EP682EP682 and P{lacW}l(2)k07015k07015&P{PZ}l(2)rK639rK639
Experimentally Determined Cytological Location
Cytogenetic map Notes References 33F-33F   (determined by in situ hybridisation)   (Prakash et al., 1992) 33F-33F   (determined by in situ hybridisation)   (Dick et al., 1991) 33F1-33F2   (determined by in situ hybridisation)   (Lloyd and Sakonju, 1991) 33F-33F   (determined by in situ hybridisation)   (Billin et al., 1991)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\pdm2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) pdm2-RA FBtr0080393  NM_078834   2175   498 pdm2-RB FBtr0080392  NM_165017   3629   893
Additional Transcript Data & Comments
Reported size (kB)	2.5 (northern blot) (Billin et al., 1991) 2.3 (northern blot) (Prakash et al., 1992) 2.2 (northern blot) (Lloyd and Sakonju, 1991, Dick et al., 1991)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein pdm2-PA   FBpp0079974   55.5   498   6.52     NP_523558   AAF53209 pdm2-PB   FBpp0079973   98.5   893   6.90     NP_723763   AAF53208
Additional Polypeptide Data & Comments
Reported size (kDa)	498 (aa); 55 (kD) (Lloyd and Sakonju, 1991) 498 (aa); 54 (kD) (Prakash et al., 1992) 475 (aa); 53 (kD) (Dick et al., 1991) 413 (aa); 45.8 (kD) (Billin et al., 1991)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Homeobox, conserved site (IPR017970) POU-specific (IPR000327) Homeobox (IPR001356) Homeodomain-like (IPR009057) Lambda repressor-like, DNA-binding (IPR010982) Homeodomain-related (IPR012287) POU (IPR013847)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140737   AE014134 AAF53208   AE014134 AAF53209   BI238172   BI364340   BI365925   BT010239 AAQ23557   BT010257 AAQ23575   BT082108   CO181887   CO268792   CO310066   CO333193   CO342174   CZ487765   EC202022   EC208572   EC213375   EC237767   EC239840   EC260469   GH740415   M65016 AAA28481   M81958 AAA28830   M93149 AAA28732   S80559 AAB21408
UniProtKB/Swiss-Prot	Q9VK71 P31369
UniProtKB/TrEMBL	Q9VK71
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage | mid -- embryonic stage | late   presumptive embryonic/larval central nervous system   (Billin et al., 1991) embryonic stage   ectoderm | striped   (Dick et al., 1991) optic lobe   (Dick et al., 1991) labral segment   (Dick et al., 1991) central nervous system | restricted   (Dick et al., 1991) embryonic/larval labral segment sense organ   (Dick et al., 1991) embryonic stage | late   embryonic/larval labral segment sense organ | precursor   (Lloyd and Sakonju, 1991) abdominal dorsal multidendritic neuron   (Lloyd and Sakonju, 1991) presumptive embryonic/larval peripheral nervous system | restricted   (Lloyd and Sakonju, 1991) sensory neuron of embryonic/larval foregut   (Lloyd and Sakonju, 1991) scolopidial ligament cell of lateral abdominal cluster of abdominal segment 1 -- abdominal segment 7   (Lloyd and Sakonju, 1991) embryonic stage | mid   neuroblast | restricted   (Billin et al., 1991) embryonic stage 5   parasegment 7   (Lloyd and Sakonju, 1991) organism | 20-40% egg length   (Prakash et al., 1992) gastrula stage   ectoderm | striped   (Billin et al., 1991) organism | segment polarity expression pattern   (Prakash et al., 1992) embryonic stage 6   organism | odd pair rule expression pattern   (Lloyd and Sakonju, 1991) embryonic stage 10   tracheal primordium   (Lloyd and Sakonju, 1991) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage | mid -- embryonic stage | late   central nervous system | restricted   (Lloyd and Sakonju, 1991) embryonic stage | early   organism | 20-50% egg length   (Billin et al., 1991) Comment:25-50% egg length embryonic stage | mid   embryonic brain | restricted   (Billin et al., 1991) embryonic/larval hindgut   (Billin et al., 1991) embryonic stage | late   abdominal 1 dorsal bipolar neuron dbp -- abdominal 7 dorsal bipolar neuron dbp   (Lloyd and Sakonju, 1991) abdominal segment 8 -- abdominal segment 9 of peripheral nervous system   (Lloyd and Sakonju, 1991) chordotonal organ of lateral thoracic cluster of prothoracic segment   (Lloyd and Sakonju, 1991) dorsal thoracic bd1   (Lloyd and Sakonju, 1991) embryonic/larval neuron   (Lloyd and Sakonju, 1991) hypophysis   (Lloyd and Sakonju, 1991) embryonic stage   embryonic brain   (Dick et al., 1991) presumptive embryonic/larval peripheral nervous system | restricted   (Dick et al., 1991) hypophysis   (Dick et al., 1991) neurogenic region   (Dick et al., 1991) presumptive embryonic/larval central nervous system | restricted   (Prakash et al., 1992) embryonic stage 5   organism | 90-100% egg length   (Prakash et al., 1992) Comment:95-100% egg length labral segment   (Lloyd and Sakonju, 1991) parasegment 7   (Lloyd and Sakonju, 1991) organism | 30-50% egg length   (Dick et al., 1991) embryonic stage 9   organism | segment polarity expression pattern   (Lloyd and Sakonju, 1991) embryonic stage 10 -- 12   embryonic ganglion mother cell | segmentally repeated & subset   (Berman et al., 2004) embryonic neuroblast | segmentally repeated & subset   (Berman et al., 2004)
Additional Descriptive Data
	pdm2 transcripts are first expressed in the cellular blastoderm stage in two broad stripes in the posterior half of the embryo. These develop into a complicated pattern of stripes. Expression is later seen along the neurectoderm and in a restricted set of cells of the CNS and PNS. Expression in the head region occurs in the optic lobe primordium, brain primordia, clypeolabrum, epiphysis, labral sense organ, and in the ventral ectodermal regions of the labial, maxillary, and mandibullary buds. pdm2 transcripts are present at maximal levels in 0-12 hr embryos and at much reduced levels at later stages. (Dick et al., 1991) In cellular blastoderm stage embryos, pdm2 is expressed in a broad band from 20-40% egg length and at the dorsal tip of the embryo. This pattern is replace by a complicated pattern of stripes. After gastrulation, 14 stripes are observed, one per parasegment. In later embryos, expression is seen in a resticted set of cells in the CNS. Maximum levels of pdm2 RNA are observed between 4 and 12 hours of embryonic development on northern blots. (Prakash et al., 1992) pdm2 transcripts are expressed at high levels during the first 12 hours of embryogenesis and in 2nd instar larvae and are detectable in other stages at reduced levels. pdm2 expression is initially seen at the cellular blastoderm stage in two bands in parasegments 7 and 11. During gastrulation, expression is seen in an odd pair-rule pattern which later becomes a segment polarity pattern with alternating wide and narrow stripes. At stage 10, expression is seen in the neurogenic region with the exception of the midline. In germband extended embryos, expression is seen in selected neurons and their support cells. Expression is also seen in some lateral and dorsal clusters of PNS cells, in the ligament cells of the chordotonal organs, and in two types of neurons (bipolar dendrite neurons and dendritic arbor cells). (Lloyd and Sakonju, 1991) pdm2 transcripts are detected predominantly in 3-6 hr embryo RNA. They are expressed in the blastoderm embryo in a band of staining from 25-50% egg length and in an anterior cap. During gastrulation, a striped pattern is observed. Later pdm2 expression is observed in discrete subsets of neuroblasts in the developing CNS, in the brain, and in the hindgut. (Billin et al., 1991)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11   ganglion mother cell GMC4-2a   (Yeo et al., 1995) neuroblast NB3-3   (Tsuji et al., 2008)
Additional Descriptive Data
	pdm2 is expressed in early stages of the developing CNS in a highly dynamic pattern that includes roughly half of the neuroblasts and several ganglion mother cells. Here, nub and pdm2 are shown to be coexpressed in GMC4-2a but not in its progenitor neuroblast or its mature progeny. (Yeo et al., 1995)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0004394    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0004394 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0004394 expression level Developmental Stage   Expression Level embryo 00-02hr    79 embryo 02-04hr    1191 embryo 04-06hr    4647 embryo 06-08hr    2414 embryo 08-10hr    1334 embryo 10-12hr    895 embryo 12-14hr    650 embryo 14-16hr    439 embryo 16-18hr    331 embryo 18-20hr    402 embryo 20-22hr    304 embryo 22-24hr    346 larva L1    207 larva L2    111 larva L3 12hr old    74 larva L3 puffstage 1-2    77 larva L3 puffstage 3-6    121 larva L3 puffstage 7-9    152 white prepupae new    148 white prepupae 12hr    106 white prepupae 24hr    345 pupae 2d postWPP    121 pupae 3d postWPP    55 pupae 4d postWPP    45 adult male 01day    41 adult male 05day    47 adult male 30day    57 adult female 01day    41 adult female 05day    27 adult female 30day    33 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    79 embryo 02-04hr  (1191) embryo 04-06hr  (4647) embryo 06-08hr  (2414) embryo 08-10hr  (1334) embryo 10-12hr  (895) embryo 12-14hr  (650) embryo 14-16hr  (439) embryo 16-18hr  (331) embryo 18-20hr  (402) embryo 20-22hr  (304) embryo 22-24hr  (346) larva L1  (207) larva L2  (111) larva L3 12hr old    74 larva L3 puffstage 1-2    77 larva L3 puffstage 3-6  (121) larva L3 puffstage 7-9  (152) white prepupae new  (148) white prepupae 12hr  106 white prepupae 24hr  (345) pupae 2d postWPP  (121) pupae 3d postWPP    55 pupae 4d postWPP    45 adult male 01day    41 adult male 05day    47 adult male 30day    57 adult female 01day    41 adult female 05day    27 adult female 30day    33 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    79 embryo 02-04hr    1191 embryo 04-06hr  (4647) embryo 06-08hr  (2414) embryo 08-10hr    1334 embryo 10-12hr    895 embryo 12-14hr    650 embryo 14-16hr    439 embryo 16-18hr    331 embryo 18-20hr    402 embryo 20-22hr    304 embryo 22-24hr    346 larva L1    207 larva L2    111 larva L3 12hr old    74 larva L3 puffstage 1-2    77 larva L3 puffstage 3-6    121 larva L3 puffstage 7-9    152 white prepupae new    148 white prepupae 12hr    106 white prepupae 24hr    345 pupae 2d postWPP    121 pupae 3d postWPP    55 pupae 4d postWPP    45 adult male 01day    41 adult male 05day    47 adult male 30day    57 adult female 01day    41 adult female 05day    27 adult female 30day    33 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    79 embryo 02-04hr    1191 embryo 04-06hr    4647 embryo 06-08hr    2414 embryo 08-10hr    1334 embryo 10-12hr    895 embryo 12-14hr    650 embryo 14-16hr    439 embryo 16-18hr    331 embryo 18-20hr    402 embryo 20-22hr    304 embryo 22-24hr    346 larva L1    207 larva L2    111 larva L3 12hr old    74 larva L3 puffstage 1-2    77 larva L3 puffstage 3-6    121 larva L3 puffstage 7-9    152 white prepupae new    148 white prepupae 12hr    106 white prepupae 24hr    345 pupae 2d postWPP    121 pupae 3d postWPP    55 pupae 4d postWPP    45 adult male 01day    41 adult male 05day    47 adult male 30day    57 adult female 01day    41 adult female 05day    27 adult female 30day    33 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    79 embryo 02-04hr    1191 embryo 04-06hr    4647 embryo 06-08hr    2414 embryo 08-10hr    1334 embryo 10-12hr    895 embryo 12-14hr    650 embryo 14-16hr    439 embryo 16-18hr    331 embryo 18-20hr    402 embryo 20-22hr    304 embryo 22-24hr    346 larva L1    207 larva L2    111 larva L3 12hr old    74 larva L3 puffstage 1-2    77 larva L3 puffstage 3-6    121 larva L3 puffstage 7-9    152 white prepupae new    148 white prepupae 12hr    106 white prepupae 24hr    345 pupae 2d postWPP    121 pupae 3d postWPP    55 pupae 4d postWPP    45 adult male 01day    41 adult male 05day    47 adult male 30day    57 adult female 01day    41 adult female 05day    27 adult female 30day    33 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0004394 expression level Developmental Stage   Expression Level embryo 00-02hr    79 embryo 02-04hr    1191 embryo 04-06hr    4647 embryo 06-08hr    2414 embryo 08-10hr    1334 embryo 10-12hr    895 embryo 12-14hr    650 embryo 14-16hr    439 embryo 16-18hr    331 embryo 18-20hr    402 embryo 20-22hr    304 embryo 22-24hr    346 larva L1    207 larva L2    111 larva L3 12hr old    74 larva L3 puffstage 1-2    77 larva L3 puffstage 3-6    121 larva L3 puffstage 7-9    152 white prepupae new    148 white prepupae 12hr    106 white prepupae 24hr    345 pupae 2d postWPP    121 pupae 3d postWPP    55 pupae 4d postWPP    45 adult male 01day    41 adult male 05day    47 adult male 30day    57 adult female 01day    41 adult female 05day    27 adult female 30day    33 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    79 embryo 02-04hr  (1191) embryo 04-06hr  (4647) embryo 06-08hr  (2414) embryo 08-10hr  (1334) embryo 10-12hr  (895) embryo 12-14hr  (650) embryo 14-16hr  (439) embryo 16-18hr  (331) embryo 18-20hr  (402) embryo 20-22hr  (304) embryo 22-24hr  (346) larva L1  (207) larva L2  111 larva L3 12hr old    74 larva L3 puffstage 1-2    77 larva L3 puffstage 3-6  121 larva L3 puffstage 7-9  (152) white prepupae new  (148) white prepupae 12hr  106 white prepupae 24hr  (345) pupae 2d postWPP  121 pupae 3d postWPP    55 pupae 4d postWPP    45 adult male 01day    41 adult male 05day    47 adult male 30day    57 adult female 01day    41 adult female 05day    27 adult female 30day    33 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    79 embryo 02-04hr    1191 embryo 04-06hr  (4647) embryo 06-08hr  2414 embryo 08-10hr    1334 embryo 10-12hr    895 embryo 12-14hr    650 embryo 14-16hr    439 embryo 16-18hr    331 embryo 18-20hr    402 embryo 20-22hr    304 embryo 22-24hr    346 larva L1    207 larva L2    111 larva L3 12hr old    74 larva L3 puffstage 1-2    77 larva L3 puffstage 3-6    121 larva L3 puffstage 7-9    152 white prepupae new    148 white prepupae 12hr    106 white prepupae 24hr    345 pupae 2d postWPP    121 pupae 3d postWPP    55 pupae 4d postWPP    45 adult male 01day    41 adult male 05day    47 adult male 30day    57 adult female 01day    41 adult female 05day    27 adult female 30day    33 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    79 embryo 02-04hr    1191 embryo 04-06hr    4647 embryo 06-08hr    2414 embryo 08-10hr    1334 embryo 10-12hr    895 embryo 12-14hr    650 embryo 14-16hr    439 embryo 16-18hr    331 embryo 18-20hr    402 embryo 20-22hr    304 embryo 22-24hr    346 larva L1    207 larva L2    111 larva L3 12hr old    74 larva L3 puffstage 1-2    77 larva L3 puffstage 3-6    121 larva L3 puffstage 7-9    152 white prepupae new    148 white prepupae 12hr    106 white prepupae 24hr    345 pupae 2d postWPP    121 pupae 3d postWPP    55 pupae 4d postWPP    45 adult male 01day    41 adult male 05day    47 adult male 30day    57 adult female 01day    41 adult female 05day    27 adult female 30day    33 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    79 embryo 02-04hr    1191 embryo 04-06hr    4647 embryo 06-08hr    2414 embryo 08-10hr    1334 embryo 10-12hr    895 embryo 12-14hr    650 embryo 14-16hr    439 embryo 16-18hr    331 embryo 18-20hr    402 embryo 20-22hr    304 embryo 22-24hr    346 larva L1    207 larva L2    111 larva L3 12hr old    74 larva L3 puffstage 1-2    77 larva L3 puffstage 3-6    121 larva L3 puffstage 7-9    152 white prepupae new    148 white prepupae 12hr    106 white prepupae 24hr    345 pupae 2d postWPP    121 pupae 3d postWPP    55 pupae 4d postWPP    45 adult male 01day    41 adult male 05day    47 adult male 30day    57 adult female 01day    41 adult female 05day    27 adult female 30day    33 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0004394    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0004394 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0004394 expression level Tissue   Expression Level Larval Central Nervous System    17.8 Larval Midgut    64.4 Larval Hindgut    34.2 Larval Malpighian Tubules    6.1 Larval Fat Body    4.2 Larval Salivary Gland    5.2 Larval Trachea    1.975 Larval Carcass    8.775 Adult Head    10.7 Adult Eye    2.925 Adult Brain    32.7 Adult Thoracic-Abdominal Ganglion    63.8 Adult Crop    12.3 Adult Midgut    75.3 Adult Hindgut    35.9 Adult Malpighian Tubules    6.5 Adult Fat Body    7.2 Adult Salivary Gland no informative data Adult Heart    1.825 Adult VirginFemale Spermatheca    5.5 Adult InseminatedFemale Spermatheca    7.2 Adult Ovary    2.8 Adult Testis    4.5 Adult Male Accessory Gland no informative data Adult Carcass    6.4 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    17.8 Larval Midgut    64.4 Larval Hindgut    34.2 Larval Malpighian Tubules    6.1 Larval Fat Body    4.2 Larval Salivary Gland    5.2 Larval Trachea    1.975 Larval Carcass    8.775 Adult Head    10.7 Adult Eye    2.925 Adult Brain    32.7 Adult Thoracic-Abdominal Ganglion    63.8 Adult Crop    12.3 Adult Midgut    75.3 Adult Hindgut    35.9 Adult Malpighian Tubules    6.5 Adult Fat Body    7.2 Adult Salivary Gland no informative data Adult Heart    1.825 Adult VirginFemale Spermatheca    5.5 Adult InseminatedFemale Spermatheca    7.2 Adult Ovary    2.8 Adult Testis    4.5 Adult Male Accessory Gland no informative data Adult Carcass    6.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    17.8 Larval Midgut    64.4 Larval Hindgut    34.2 Larval Malpighian Tubules    6.1 Larval Fat Body    4.2 Larval Salivary Gland    5.2 Larval Trachea    1.975 Larval Carcass    8.775 Adult Head    10.7 Adult Eye    2.925 Adult Brain    32.7 Adult Thoracic-Abdominal Ganglion    63.8 Adult Crop    12.3 Adult Midgut    75.3 Adult Hindgut    35.9 Adult Malpighian Tubules    6.5 Adult Fat Body    7.2 Adult Salivary Gland no informative data Adult Heart    1.825 Adult VirginFemale Spermatheca    5.5 Adult InseminatedFemale Spermatheca    7.2 Adult Ovary    2.8 Adult Testis    4.5 Adult Male Accessory Gland no informative data Adult Carcass    6.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    17.8 Larval Midgut    64.4 Larval Hindgut    34.2 Larval Malpighian Tubules    6.1 Larval Fat Body    4.2 Larval Salivary Gland    5.2 Larval Trachea    1.975 Larval Carcass    8.775 Adult Head    10.7 Adult Eye    2.925 Adult Brain    32.7 Adult Thoracic-Abdominal Ganglion    63.8 Adult Crop    12.3 Adult Midgut    75.3 Adult Hindgut    35.9 Adult Malpighian Tubules    6.5 Adult Fat Body    7.2 Adult Salivary Gland no informative data Adult Heart    1.825 Adult VirginFemale Spermatheca    5.5 Adult InseminatedFemale Spermatheca    7.2 Adult Ovary    2.8 Adult Testis    4.5 Adult Male Accessory Gland no informative data Adult Carcass    6.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0004394 expression level Tissue   Expression Level Larval Central Nervous System    17.8 Larval Midgut    64.4 Larval Hindgut    34.2 Larval Malpighian Tubules    6.1 Larval Fat Body    4.2 Larval Salivary Gland    5.2 Larval Trachea    1.975 Larval Carcass    8.775 Adult Head    10.7 Adult Eye    2.925 Adult Brain    32.7 Adult Thoracic-Abdominal Ganglion    63.8 Adult Crop    12.3 Adult Midgut    75.3 Adult Hindgut    35.9 Adult Malpighian Tubules    6.5 Adult Fat Body    7.2 Adult Salivary Gland no informative data Adult Heart    1.825 Adult VirginFemale Spermatheca    5.5 Adult InseminatedFemale Spermatheca    7.2 Adult Ovary    2.8 Adult Testis    4.5 Adult Male Accessory Gland no informative data Adult Carcass    6.4 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    17.8 Larval Midgut    64.4 Larval Hindgut    34.2 Larval Malpighian Tubules    6.1 Larval Fat Body    4.2 Larval Salivary Gland    5.2 Larval Trachea    1.975 Larval Carcass    8.775 Adult Head    10.7 Adult Eye    2.925 Adult Brain    32.7 Adult Thoracic-Abdominal Ganglion    63.8 Adult Crop    12.3 Adult Midgut    75.3 Adult Hindgut    35.9 Adult Malpighian Tubules    6.5 Adult Fat Body    7.2 Adult Salivary Gland no informative data Adult Heart    1.825 Adult VirginFemale Spermatheca    5.5 Adult InseminatedFemale Spermatheca    7.2 Adult Ovary    2.8 Adult Testis    4.5 Adult Male Accessory Gland no informative data Adult Carcass    6.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    17.8 Larval Midgut    64.4 Larval Hindgut    34.2 Larval Malpighian Tubules    6.1 Larval Fat Body    4.2 Larval Salivary Gland    5.2 Larval Trachea    1.975 Larval Carcass    8.775 Adult Head    10.7 Adult Eye    2.925 Adult Brain    32.7 Adult Thoracic-Abdominal Ganglion    63.8 Adult Crop    12.3 Adult Midgut    75.3 Adult Hindgut    35.9 Adult Malpighian Tubules    6.5 Adult Fat Body    7.2 Adult Salivary Gland no informative data Adult Heart    1.825 Adult VirginFemale Spermatheca    5.5 Adult InseminatedFemale Spermatheca    7.2 Adult Ovary    2.8 Adult Testis    4.5 Adult Male Accessory Gland no informative data Adult Carcass    6.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    17.8 Larval Midgut    64.4 Larval Hindgut    34.2 Larval Malpighian Tubules    6.1 Larval Fat Body    4.2 Larval Salivary Gland    5.2 Larval Trachea    1.975 Larval Carcass    8.775 Adult Head    10.7 Adult Eye    2.925 Adult Brain    32.7 Adult Thoracic-Abdominal Ganglion    63.8 Adult Crop    12.3 Adult Midgut    75.3 Adult Hindgut    35.9 Adult Malpighian Tubules    6.5 Adult Fat Body    7.2 Adult Salivary Gland no informative data Adult Heart    1.825 Adult VirginFemale Spermatheca    5.5 Adult InseminatedFemale Spermatheca    7.2 Adult Ovary    2.8 Adult Testis    4.5 Adult Male Accessory Gland no informative data Adult Carcass    6.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    10.7   NA  Eye    2.925   NA  Brain    32.7   17.8  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    63.8   NA  Crop    12.3   64.4  Midgut    75.3   34.2  Hindgut    35.9   6.1  Malpighian Tubules    6.5   4.2  Fat Body    7.2   5.2  Salivary Gland    no informative data   NA  Heart    1.825   1.975  Trachea    NA   NA  VirginFemale Spermatheca    5.5   NA  InseminatedFemale Spermatheca    7.2   NA  Ovary    2.8   NA  Testis    4.5   NA  Male Accessory Gland    no informative data   8.775  Carcass    6.4 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_31
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004394 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12287-RB FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for pdm2 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal pdm2Δmiti.Hsp83 lethal | heat sensitive pdm2Δmiti.hs viable pdm2d09994 viable, with Scer\GAL4pnr-MD237 pdm2GD5046 Sterility Allele fertile pdm2d09994 Other Phenotypes Allele neuroanatomy defective | embryonic stage pdm2Scer\UAS.T:Ivir\HA1 neuroanatomy defective | embryonic stage, with Scer\GAL4pros.PMG pdm2Scer\UAS.T:Ivir\HA1 Phenotype manifest in Allele embryonic abdominal segment 2 pdm2Δmiti.Hsp83 embryonic abdominal segment 2 | heat sensitive pdm2Δmiti.hs embryonic abdominal segment 6 | heat sensitive pdm2Δmiti.hs embryonic ganglion mother cell | ectopic pdm2hs.P ganglion mother cell pdm2Δmiti.Hsp83 ganglion mother cell | heat sensitive pdm2Δmiti.hs ganglion mother cell GMC4-2a pdm2E46 larval abdominal segment 1 pdm2hs.PC larval abdominal segment 2 pdm2hs.PC larval abdominal segment 3 pdm2hs.PC larval head pdm2hs.PC neuroblast NB3-3 | embryonic stage pdm2Scer\UAS.T:Ivir\HA1 neuroblast NB4-2 pdm2hs.P RP2 neuron pdm2Δmiti.Hsp83 pdm2E45 pdm2E46 pdm2PR13 pdm2hs.P RP2 neuron | ectopic pdm2hs.P RP2 neuron | heat sensitive pdm2Δmiti.hs RP2sib neuron pdm2Δmiti.Hsp83 RP2sib neuron | heat sensitive pdm2Δmiti.hs U3 neuron, with Scer\GAL4en-e16E pdm2Scer\UAS.T:Ivir\HA1 U4 neuron, with Scer\GAL4en-e16E pdm2Scer\UAS.T:Ivir\HA1 U5 neuron | supernumerary, with Scer\GAL4en-e16E pdm2Scer\UAS.T:Ivir\HA1 U5 neuron | supernumerary, with Scer\GAL4pros.PMG pdm2Scer\UAS.T:Ivir\HA1
Classical Alleles ( 11 )
For All Classical Alleles Show
Allele of pdm2 Class Mutagen Stocks Known lesion pdm2d09994 P-element activity 2 -- pdm2E46 antimorphic allele - genetic evidence ethyl methanesulfonate 1 Yes pdm2f02059 1 -- pdm2f05144 piggyBac transposase 1 -- pdm2MB00894 1 -- pdm2MI02425 1 -- pdm21602 Delta2-3 0 Yes pdm2971 Delta2-3 0 Yes pdm2E45 ethyl methanesulfonate 0 Yes pdm2MI03610 0 -- pdm2PR13 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of pdm2 Class Mutagen Stocks Known lesion pdm2GD16857 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes pdm2GD5046 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes pdm2JF02405 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes pdm2KK110854 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes pdm2hs.P in vitro construct - regulatory fusion 0 Yes pdm2hs.PC in vitro construct - regulatory fusion 0 Yes pdm2Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes pdm2Δmiti.hs in vitro construct - regulatory fusion 0 Yes pdm2Δmiti.Hsp83 antimorphic allele - genetic evidence in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel6034 (Ryder, 2004.4.26) Df(2L)GR4 (Brewster et al., 2001, Yeo et al., 1995) Df(2L)pdm2GR19 (Yeo et al., 1995) Df(2L)pdm-2PR6 (Yeo et al., 1995) Df(2L)prd1.7 (Bhat and Schedl, 1994, Yeo et al., 1995)
Duplicated in	Dp(2;2)GYL (Bhat and Schedl, 1994)
Not disrupted in	Df(2L)Prl (Bhat and Schedl, 1994, Yeo et al., 1995)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5046} NA P{GD16857} NA P{KK110854} NA P{TRiP.JF02405} NA reporter construct P{pdm2-lacZ.+1} No P{pdm2-lacZ.+3} No heat-shock construct P{hsp70-pdm2} NA P{hsp70-Δmiti} NA P{hsp83-Δmiti} NA P{hs-pdm-2} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}pdm2MI02425 NA Mi{MIC}pdm2MI03610 NA P{?white-un4}pdm2PR13 NA P{white-un4}pdm2971 NA P{white-un4}pdm21602 NA PBac{WH}pdm2f02059 NA PBac{WH}pdm2f05144 NA insertion of mobile activating element P{XP}pdm2d09994 NA insertion of enhancer trap binary system Mi{ET1}pdm2MB00894 No
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function
CV term Evidence References
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription inferred from direct assay (Junell et al., 2007)
Biological Process
CV term Evidence References
neuroblast development inferred from mutant phenotype (Tsuji et al., 2008)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
DNA binding non-traceable author statement (Swiss-Prot Project Members, 1993.7.1) sequence-specific DNA binding inferred from electronic annotation with InterPro:IPR001356, InterPro:IPR017970 (FlyBase Curators et al., 2004-) sequence-specific DNA binding transcription factor activity inferred from sequence or structural similarity with UniProtKB:P09086 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1993.7.1)
Biological Process
CV term Evidence References
nervous system development non-traceable author statement (Swiss-Prot Project Members, 1993.7.1) regulation of transcription, DNA-dependent inferred from sequence or structural similarity with UniProtKB:P09086 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity with UniProtKB:P09086 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1993.7.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions pdm2 allele Gene References pdm2hs.P numb (Bhat and Apsel, 2004) unspecified D (Nambu et al., 1997)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60717 DroID - A comprehensive database of gene and protein interactions. • FBgn0004394 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34673
Orthologs
Genome-wide drosophilid orthologs	Dana\GF14202 Dere\GG23792 Dgri\GH10117 Dmoj\GI14490 Dper\GL19359 Dpse\GA11534 Dsec\GM26881 Dsim\GD23847 Dvir\pdm2 Dwil\GK15507 Dyak\GE18596
Curated drosophilid orthologs	Dpse\GA11534   Dvir\pdm2
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • JA00959 Caenorhabditis japonica (nematode) ENSCPOP00000010992 Cavia porcellus (guinea pig) RP27749 Caenorhabditis remanei (nematode) ENSDARP00000003648 Danio rerio (zebra fish) ENSGACP00000018109 Gymnopilus aculeatus (mushroom) ISCW022240-PA Ixodes scapularis (deer tick) ENSMMUP00000022510 Macaca mulatta (rhesus monkey) ENSMUSP00000104056 Mus musculus (house mouse) PHUM008777-PA Pediculus humanus (human body louse) NP_001015510.1 Strongylocentrotus purpuratus (purple sea urchin) XP_968439.1 Tribolium castaneum (red flour beetle) ENSTRUP00000032463 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000013682 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0236003 FBgn0217512 FBgn0020449 FBgn0195217 FBgn0181731 FBgn0071585 FBgn0156958 FBgn0137242 FBgn0117598 FBgn0115931 FBgn0091229
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	8855 pdm2E46/CyO 19325 w1118; P{XP}pdm2d09994 29543 y1 v1; P{TRiP.JF02405}attP2 35088 y1 w*; Mi{MIC}pdm2MI02425 22925 y1 w67c23; Mi{ET1}pdm2MB00894
Harvard	- P{XP}pdm2d09994 - PBac{WH}pdm2f02059 - PBac{WH}pdm2f05144
VDRC	v102126 P{KK110854}VIE-260B v30708 w1118; P{GD5046}v30708 v52272 w1118; P{GD16857}v52272/TM3
Genomic Clones ( 1 )
	BACR28A12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 16 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE34565 RE49429
Other clones	MIP04269
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE51329
Other clones	97627 97906 124791 281228 CK01.121A.H8 CK00427 EC15179 EK092664 EK220352 EK306154 EP14112 RP001025900
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004394 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34673
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: pdm2 CG15486 CG15487 (FlyBase Genome Annotators, 2002-2003)
Additional comments	Annotations CG12287, CG15486 and CG15487 merged as CG12287 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
Other Comments
	nub/pdm2 and cas regulate late-born motor neuron identity within the NB7-1 lineage; nub/pdm2 specifies fourth-born U4 motor neuron identity, while nub/pdm2/cas together specify fifth-born U5 motor neuron identity. (Grosskortenhaus et al., 2006) Virtually all aspects of pdm2 RNA expression are conserved between D.melanogaster and D.virilis. (Poole, 1995) nub and pdm2 both contribute toward the development of a full complement of mature RP2 neurons by being expressed in and acting on ganglion mother cell 2a (GMC-2a), the RP2 progenitor cell. nub plays a quantitatively less important role than pdm2. nub and pdm2 act to specify GMC-2a cell identity and not merely act to positively regulate GMC-2a cell division. Within the hierarchy of genes expressed in GMC4-2a nub and pdm2 lie downstream of pros and ftz and upstream of eve. (Yeo et al., 1995) pdm2 is required for segmentation and neurogenesis. (Bhat and Schedl, 1994) The genomic organisation and early embryonic expression pattern of pdm2 has been determined. (Cockerill et al., 1993) The pdm2 gene product specifies the cell fate of GMC-1 in the NB4-2 lineage. Its ectopic expression in the two progeny cells of GMC-1 is sufficient to cause both the cells to adopt a GMC-1 cell identity. (Yang et al., 1993) pdm2 is transcribed in elements of the developing nervous system suggesting a functional role in neurogenesis and neurospecification. (Dick et al., 1992) pdm2 has been cloned and its spatial expression patterns characterized. pdm2 belongs to the class II type of POU genes. The pdm2 gene product is an octamer-dependent transcription factor that is capable of activating transcription in yeast. (Prakash et al., 1992) pdm2 contains a POU domain, and is expressed at maximum levels during early development. (Billin et al., 1991) The cDNA sequences of pdm2 and nub and their developmental expression patterns have been determined. (Dick et al., 1991) The spatial expression pattern of pdm2 has been characterized. (Lloyd and Sakonju, 1991)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078834 NM_165017 RefSeq (Proteins) • NP_523558 NP_723763 DDBJ / EMBL / GenBank • AAA28481 AAA28732 AAA28830 AAB21408 AAF53208 AAF53209 AAQ23557 AAQ23575 BI238172 BI364340 BT010239 BT010257 CZ487765 M65016 M81958 M93149 S80559 Entrez Gene - A searchable database of RefSeq genes. • 34673 UniProtKB/Swiss-Prot • P31369 Q9VK71 UniProtKB/TrEMBL • Q9VK71
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Homeobox, conserved site (IPR017970) POU-specific (IPR000327) Homeobox (IPR001356) Homeodomain-like (IPR009057) Lambda repressor-like, DNA-binding (IPR010982) Homeodomain-related (IPR012287) POU (IPR013847)
Linkouts
	BioGRID - A database of protein and genetic interactions • 60717 DroID - A comprehensive database of gene and protein interactions. • FBgn0004394 DRSC - Results from RNAi screens. • FBgn0004394 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004394 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12287-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004394 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34673 InParanoid A subset of ortholog calls from InParanoid. • JA00959 Caenorhabditis japonica (nematode) ENSCPOP00000010992 Cavia porcellus (guinea pig) RP27749 Caenorhabditis remanei (nematode) ENSDARP00000003648 Danio rerio (zebra fish) ENSGACP00000018109 Gymnopilus aculeatus (mushroom) ISCW022240-PA Ixodes scapularis (deer tick) ENSMMUP00000022510 Macaca mulatta (rhesus monkey) ENSMUSP00000104056 Mus musculus (house mouse) PHUM008777-PA Pediculus humanus (human body louse) NP_001015510.1 Strongylocentrotus purpuratus (purple sea urchin) XP_968439.1 Tribolium castaneum (red flour beetle) ENSTRUP00000032463 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000013682 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /gene/pdm-2.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34673 modMine - Data generated by the modENCODE project. • FBgn0004394 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0236003 FBgn0217512 FBgn0020449 FBgn0195217 FBgn0181731 FBgn0071585 FBgn0156958 FBgn0137242 FBgn0117598 FBgn0115931 FBgn0091229 REDfly - A database of transcriptional regulatory elements. • FBgn0004394
Synonyms & Secondary IDs ( 23 )
Reported As
Symbol Synonym	CG12287 (Klebes et al., 2005, Kreiman, 2004, Keleman et al., 2009.8.5, Perkins et al., 2009, Macdonald and Long, 2006) CG15486   CG15487   dim (Prakash et al., 1992, ) dOct2 (Prakash et al., 1992, ) dPOU28 (Yeo et al., 1995, Yang et al., 1993, Dick et al., 1992, ) dpou28 (Jan and Jan, 1994) dPOU-28 (Goodman and Doe, 1993, Cabrera, 1992, Dick et al., 1991, ) dPOU28/pdm-2 (Yang et al., 1993, Jimenez and Modolell, 1993, Yang et al., 1993) miti (Bhat and Apsel, 2004, Mehta and Bhat, 2001, Bhat et al., 1995, Bhat and Schedl, 1993, Bhat and Schedl, 1994) Oct-2 (Malin et al., 2005) Oct2 (Malin et al., 2005) pdm (Rougvie, 2005, Grosskortenhaus et al., 2005, Abbott, 2003, Harris, 2001, Pearson and Doe, 2003, Kanai et al., 2003, Bellaiche and Schweisguth, 2001, Odenwald, 2005, Tran and Doe, 2007, Tsuji et al., 2008, Nakajima et al., 2010) Pdm (Grosskortenhaus et al., 2006) pdm-2 (Brody et al., 2005, Brody et al., 2003, Edenfeld et al., 2002, Brody and Odenwald, 2002, Bergman and Kreitman, 2001, Hemavathy et al., 2000, Ashraf et al., 2000, Lloyd, 1995.12.4, Billin, 1991.12.16, Ashraf et al., 1999, Eisen, 1998, Nambu et al., 1997, Ryan and Rosenfeld, 1997, Odenwald et al., 1997, Odenwald et al., 1996, McDonald and Doe, 1996, Skeath, 1995, McDonald et al., 1995, Poole, 1995, Jan and Jan, 1994, Manning and Krasnow, 1993, Cockerill et al., 1993, Billin et al., 1991, ) Pdm2 (Fichelson et al., 2005, Tsuji et al., 2008, Mace et al., 2010) Pdm-2 (Ma et al., 2000, Odenwald et al., 1999, Brody and Odenwald, 1999, Brody and Odnewald, 1999, Brody and Odenwald, 1999, Nakagoshi et al., 1998) pdm2 (Grosskortenhaus et al., 2006, Wheeler et al., 2006, Jacobsen et al., 2006, Kreiman, 2004, Junell et al., 2007, Segal et al., 2008, Berman et al., 2004, Wheeler et al., 2008, Tran and Doe, 2008, Yu and Small, 2008, Gaziova and Bhat, 2009, Stagg et al., 2011, Tomancak et al., 2007, Macdonald and Long, 2006, Tran et al., 2010, Kazemian et al., 2010) POU domain protein 2 (Edwards et al., 2006)
Name Synonym	didymous   miti-mere (Odenwald et al., 1996, Bhat and Schedl, 1994) Miti-mere (Bhat and Schedl, 1993) POU domain prot 2 (Carpenter et al., 2009) POU domain protein 2 (Edwards et al., 2006, Wheeler et al., 2006, Berman et al., 2004, Yu and Small, 2008, Macdonald and Long, 2006)
Secondary FlyBase IDs
	FBgn0032441 FBgn0032443
References ( 119 )
Generate a list of	All references relating to this gene ( 119 )
List References by type	Research paper  ( 52 ) Supplementary material  ( 2 ) Review  ( 20 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 23 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 2 ) Protein sequence record  ( 1 ) Computer file  ( 4 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 7 )
	Gabilondo et al., 2011, Mech. Dev. 128(3-4): 208--221 A targeted genetic screen identifies crucial players in the specification of the Drosophila abdominal Capaergic neurons. [FBrf0213290] Stagg et al., 2011, Development 138(11): 2171--2183 Dual role for Drosophila lethal of scute in CNS midline precursor formation and dopaminergic neuron and motoneuron cell fate. [FBrf0213671] Kazemian et al., 2010, PLoS Biol. 8(8): Quantitative analysis of the Drosophila segmentation regulatory network using pattern generating potentials. [FBrf0211688] Losada-Pérez et al., 2010, Mech. Dev. 127(9-12): 458--471 Lineage-unrelated neurons generated in different temporal windows and expressing different combinatorial codes can converge in the activation of the same terminal differentiation gene. [FBrf0212045] Mace et al., 2010, Bioinformatics 26(6): 761--769 Extraction and comparison of gene expression patterns from 2D RNA in situ hybridization images. [FBrf0210155] Nakajima et al., 2010, PLoS Comput. Biol. 6(4): e1000760 Robustness under functional constraint: the genetic network for temporal expression in Drosophila neurogenesis. [FBrf0210747] Tran et al., 2010, Development 137(9): 1421--1430 Recombineering Hunchback identifies two conserved domains required to maintain neuroblast competence and specify early-born neuronal identity. [FBrf0210578] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...