• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\CrebA

General Information
Symbol	Dmel\CrebA	Species	D. melanogaster
Name	Cyclic-AMP response element binding protein A	Annotation symbol	CG7450
Feature type	protein_coding_gene	FlyBase ID	FBgn0004396
Gene Model Status	Current	Stock availability	12 publicly available
Also Known As	dCreb-A, CREB, dCREBA, CREB-a, BBF-2
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	71E1-71E1	Sequence location	3L:15,528,495..15,546,314 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Cyclic-AMP response element binding protein A is referred to in FlyBase by the symbol Dmel\CrebA (CG7450, FBgn0004396). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: sequence-specific DNA binding transcription factor activity; enhancer sequence-specific DNA binding; sequence-specific DNA binding; DNA binding. There is experimental evidence that it is involved in the biological process: dorsal/ventral pattern formation; chitin-based larval cuticle pattern formation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; larval chitin-based cuticle development; salivary gland development. 27 alleles are reported. The phenotypes of these alleles are annotated with: larva; embryonic/larval salivary gland; ommatidium; embryonic/larval cuticle. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Basic-leucine zipper domain; Eukaryotic transcription factor, Skn-1-like, DNA-binding; cAMP response element binding (CREB) protein. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-18 hour embryonic stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult salivary gland, inseminated spermatheca, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult midgut, larval hindgut, larval/adult fat body, larval trachea, virgin spermatheca, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1627571_at completely aligns to an exonic region of only a subset of 1 of the 2 FlyBase-annotated transcript isoforms of CrebA. Gene sequence location is 3L:15528495..15546314.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03	Alleles CrebA[MI06441]
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 71E1-71E1   Limits computationally determined from genome sequence between P{lacW}cp309s2172&P{lacW}l(3)j2A2j2A2 and P{EP}Tfb2EP572
Experimentally Determined Cytological Location
Cytogenetic map Notes References 71D1-71D2   (determined by in situ hybridisation)   (Spradling et al., 1999) 71D1-71D2   (determined by in situ hybridisation)   (BDGP Project Members, 1994-1999) 25C-25D   (determined by in situ hybridisation)   (Abel et al., 1992)   Placed in 71C--71D by deficiency mapping.   (Rose et al., 1997)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CrebA for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50 Low-frequency RNA-Seq exon junction(s) not annotated. DGC clone appears problematic (SD05937): polyA-primed genomic contaminant
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CrebA-RA FBtr0075557  NM_079363   3189   516 CrebA-RB FBtr0075558  NM_206374   4498   516
Additional Transcript Data & Comments
Reported size (kB)	4.4 (northern blot) (Smolik-Utlaut et al., 1992) 4.3 (northern blot) (Abel et al., 1992)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CrebA-PA   FBpp0075311   56.3   516   6.31     NP_524087   AAF49621 CrebA-PB   FBpp0089339   56.3   516   6.31     NP_996096   AAS64997
Additional Polypeptide Data & Comments
Reported size (kDa)	516 (aa); 56.3 (kD) (Smolik-Utlaut et al., 1992) 515 (aa); 56 (kD) (Abel et al., 1992)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Basic-leucine zipper domain (IPR004827) Eukaryotic transcription factor, Skn-1-like, DNA-binding (IPR008917) cAMP response element binding (CREB) protein (IPR001630)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141154   AE014296 AAF49621   AE014296 AAS64997   AI541662   AQ034057   AW944445   AY122251 AAM52763   BG636528   BI355920   BI368443   BI639496   BP552852   BP552853   BT011074   BT021243 AAX33391   BT025219   CL943677   CO182767   CO188599   CO189362   CO189616   CO189866   CO193452   CO264681   CO269515   CO276581   CO276987   CO282341   CO291668   CO293837   CO294337   CO299017   CO319198   CO323890   CO325755   CO332352   CO333808   CO334064   CO338617   CO340292   CO344187   CZ484246   CZ484247   CZ487823   CZ488815   CZ489984   DN154078   EC060659   EC061018   EC064526   EC071209   EC072503   EC074992   EC083118   EC090619   EC090831   EC195291   EC197679   EC199176   EC200760   EC201347   EC201475   EC206089   EC215576   EC216020   EC218157   EC218213   EC222293   EC222473   EC235925   EC238216   EC241262   EC253342   EC258551   G00569   GH747708   GH750400   GH751621   GH757273   GH758812   GH761232   GH776265   GH776339   GH781170   GH782044   GH788781   GH790998   GH792507   GH792762   GH809215   GH811147   GH813628   GH817839   GH821944   GH822478   GH823052   GH841381   GH846123   GH846874   GH851032   GH851451   GH852050   GH858339   GH863780   GH864347   GH866028   GH870137   GH871556   GH871923   GH873433   GH875719   GH880137   GH883879   GH887136   GH890567   GH891527   GH893437   GH894123   GH897570   GH903960   GH910202   GH912347   GH923606   GH924115   GH924947   GH925712   GH930876   GH933781   GH934172   GH935289   GH942679   GH943026   GH943907   GH946910   GH950925   GH951424   GH953369   GH955567   GH956315   GH956888   GH959964   GH960834   GH961900   GH962377   GH964622   GH964702   GH966117   GH966608   GH970912   GH971149   GH972257   GH975103   GH976203   GH976920   GH981640   GH982172   GH982291   GH982599   GH982824   M87038 AAA28427   X64429 CAA45771
UniProtKB/Swiss-Prot	P29747
UniProtKB/TrEMBL	Q1LZ07 Q5BII1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References regulatory region FBsf0000435418 3L:15,524,089..15,525,191 evidence=Reporter construct (in vivo) (Abrams and Andrew, 2005, Halfon, 2012.6.19) regulatory region FBsf0000435534 3L:15,523,345..15,524,111 evidence=Reporter construct (in vivo) (Abrams and Andrew, 2005, Halfon, 2012.6.19)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   embryonic/larval trachea   (Abel et al., 1992) embryonic/larval digestive system   (Abel et al., 1992) adult stage   adult midgut   (Smolik-Utlaut et al., 1992) optic lobe   (Smolik-Utlaut et al., 1992) adult salivary gland   (Smolik-Utlaut et al., 1992) adult stage | male   ejaculatory duct   (Smolik-Utlaut et al., 1992) adult stage & oogenesis   follicle cell   (Smolik-Utlaut et al., 1992) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   embryonic/larval salivary gland   (Smolik-Utlaut et al., 1992) embryonic stage 4 -- 6   anlage in statu nascendi   (Fisher et al., 2012) anterior endoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi yolk nucleus   (Fisher et al., 2012) embryonic stage 7 -- 8   anterior endoderm anlage   (Fisher et al., 2012) hindgut anlage   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) yolk nucleus   (Fisher et al., 2012) embryonic stage 9 -- 10   amnioserosa   (Fisher et al., 2012) anterior endoderm   (Fisher et al., 2012) dorsal ectoderm   (Fisher et al., 2012) inclusive hindgut primordium   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) salivary gland body primordium   (Fisher et al., 2012) Comment:reported as salivary gland body specific anlage yolk nucleus   (Fisher et al., 2012) embryonic stage 11 -- 12   amnioserosa   (Fisher et al., 2012) dorsal epidermis primordium   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) plasmatocyte primordium   (Fisher et al., 2012) Comment:reported as plasmatocytes anlage proventriculus primordium   (Fisher et al., 2012) salivary gland body primordium   (Fisher et al., 2012) tracheal primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   amnioserosa   (Fisher et al., 2012) dorsal head epidermis   (Fisher et al., 2012) embryonic dorsal epidermis   (Fisher et al., 2012) embryonic proventriculus   (Fisher et al., 2012) embryonic ventral epidermis   (Fisher et al., 2012) embryonic/larval dorsal trunk   (Fisher et al., 2012) embryonic/larval salivary gland   (Fisher et al., 2012) embryonic/larval salivary gland body   (Fisher et al., 2012) adult stage   adult brain   (Smolik-Utlaut et al., 1992) adult proventriculus   (Smolik-Utlaut et al., 1992) adult stage | male   ejaculatory bulb   (Smolik-Utlaut et al., 1992) seminal vesicle   (Smolik-Utlaut et al., 1992) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Abel et al., 1992) RNase protection, primer extension, SI map Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   embryonic/larval fat body   (Abel et al., 1992)
Additional Descriptive Data
	In embryos, CrebA transcripts are expressed in the developing salivary gland. In the adult, transcripts are found in the brain and optic lobe cell bodies, in salivary gland, and in midgut epithelial cells of the cardia. In females CrebA transcripts are expressed in columnar follicle cells. In males, they are expressed in the seminal vesicle, ejaculatory duct, and ejaculatory bulb. (Smolik-Utlaut et al., 1992) CrebA transcripts are observed throughout development on northern blots with the highest levels in embryos and adults males. RNAse protection experiments show equivalent levels of CrebA transcripts in third instar larval gut, fat body, and trachea. (Abel et al., 1992)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
enzyme assay or biochemical detection Stage Tissue/Position (including subcellular localization) Reference oogenesis & adult stage | female   ovary   (Abel et al., 1992) immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11 -- 12   presumptive embryonic salivary gland   • nucleus (Bradley et al., 2003) embryonic stage 11 -- 13   salivary gland body primordium   (Andrew et al., 2000)
Additional Descriptive Data
	CrebA protein is present in nuclear extracts. (Abel et al., 1992)
Marker for
	embryonic salivary gland
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nucleus inferred from direct assay (Abel et al., 1992, Jattani et al., 2009)
Expression Deduced from Reporters
Reporter: P{lacW}B204 Stage Tissue/Position (including subcellular localization) Reference embryonic stage   presumptive embryonic salivary gland   (Zeng et al., 1993) embryonic proventriculus   (Rose et al., 1997) posterior spiracle primordium | surrounding   (Rose et al., 1997) amnioserosa   (Zeng et al., 1993) embryonic stage 11 -- 17   salivary gland   (Rose et al., 1997) Reporter: P{PZ}CrebA03576 Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11 -- third instar larval stage   salivary gland   (Rose et al., 1997) embryonic stage 15 -- 16   stomodeum   (Rose et al., 1997) posterior spiracle primordium | surrounding   (Rose et al., 1997) adult stage   spermathecum   (Rose et al., 1997) oogenesis stage S9 -- S10 & adult stage | female   follicle cell   (Rose et al., 1997)
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult salivary gland, inseminated spermatheca, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult midgut, larval hindgut, larval/adult fat body, larval trachea, virgin spermatheca, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    58.875 Larval Midgut    242.4 Larval Hindgut    209.4 Larval Malpighian Tubules    80.4 Larval Fat Body    154.3 Larval Salivary Gland    1953.4 Larval Trachea    132.2 Larval Carcass    267.575 Adult Head    95.1 Adult Eye    46.875 Adult Brain    37.9 Adult Thoracic-Abdominal Ganglion    36.5 Adult Crop    95.4 Adult Midgut    188.9 Adult Hindgut    91 Adult Malpighian Tubules    96.6 Adult Fat Body    289.8 Adult Salivary Gland    927.7 Adult Heart    74.025 Adult VirginFemale Spermatheca    428.5 Adult InseminatedFemale Spermatheca    571.7 Adult Ovary    39.8 Adult Testis    37.9 Adult Male Accessory Gland    873.4 Adult Carcass    70.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    58.875 Larval Midgut    242.4 Larval Hindgut    209.4 Larval Malpighian Tubules    80.4 Larval Fat Body    154.3 Larval Salivary Gland  (1953.4) Larval Trachea    132.2 Larval Carcass    267.575 Adult Head    95.1 Adult Eye    46.875 Adult Brain    37.9 Adult Thoracic-Abdominal Ganglion    36.5 Adult Crop    95.4 Adult Midgut    188.9 Adult Hindgut    91 Adult Malpighian Tubules    96.6 Adult Fat Body    289.8 Adult Salivary Gland  (927.7) Adult Heart    74.025 Adult VirginFemale Spermatheca    428.5 Adult InseminatedFemale Spermatheca  (571.7) Adult Ovary    39.8 Adult Testis    37.9 Adult Male Accessory Gland  (873.4) Adult Carcass    70.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    58.875 Larval Midgut    242.4 Larval Hindgut    209.4 Larval Malpighian Tubules    80.4 Larval Fat Body    154.3 Larval Salivary Gland  (1953.4) Larval Trachea    132.2 Larval Carcass    267.575 Adult Head    95.1 Adult Eye    46.875 Adult Brain    37.9 Adult Thoracic-Abdominal Ganglion    36.5 Adult Crop    95.4 Adult Midgut    188.9 Adult Hindgut    91 Adult Malpighian Tubules    96.6 Adult Fat Body    289.8 Adult Salivary Gland    927.7 Adult Heart    74.025 Adult VirginFemale Spermatheca    428.5 Adult InseminatedFemale Spermatheca    571.7 Adult Ovary    39.8 Adult Testis    37.9 Adult Male Accessory Gland    873.4 Adult Carcass    70.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    58.875 Larval Midgut    242.4 Larval Hindgut    209.4 Larval Malpighian Tubules    80.4 Larval Fat Body    154.3 Larval Salivary Gland    1953.4 Larval Trachea    132.2 Larval Carcass    267.575 Adult Head    95.1 Adult Eye    46.875 Adult Brain    37.9 Adult Thoracic-Abdominal Ganglion    36.5 Adult Crop    95.4 Adult Midgut    188.9 Adult Hindgut    91 Adult Malpighian Tubules    96.6 Adult Fat Body    289.8 Adult Salivary Gland    927.7 Adult Heart    74.025 Adult VirginFemale Spermatheca    428.5 Adult InseminatedFemale Spermatheca    571.7 Adult Ovary    39.8 Adult Testis    37.9 Adult Male Accessory Gland    873.4 Adult Carcass    70.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    58.875 Larval Midgut    242.4 Larval Hindgut    209.4 Larval Malpighian Tubules    80.4 Larval Fat Body    154.3 Larval Salivary Gland    1953.4 Larval Trachea    132.2 Larval Carcass    267.575 Adult Head    95.1 Adult Eye    46.875 Adult Brain    37.9 Adult Thoracic-Abdominal Ganglion    36.5 Adult Crop    95.4 Adult Midgut    188.9 Adult Hindgut    91 Adult Malpighian Tubules    96.6 Adult Fat Body    289.8 Adult Salivary Gland    927.7 Adult Heart    74.025 Adult VirginFemale Spermatheca    428.5 Adult InseminatedFemale Spermatheca    571.7 Adult Ovary    39.8 Adult Testis    37.9 Adult Male Accessory Gland    873.4 Adult Carcass    70.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    58.875 Larval Midgut    242.4 Larval Hindgut    209.4 Larval Malpighian Tubules    80.4 Larval Fat Body    154.3 Larval Salivary Gland  (1953.4) Larval Trachea    132.2 Larval Carcass    267.575 Adult Head    95.1 Adult Eye    46.875 Adult Brain    37.9 Adult Thoracic-Abdominal Ganglion    36.5 Adult Crop    95.4 Adult Midgut    188.9 Adult Hindgut    91 Adult Malpighian Tubules    96.6 Adult Fat Body    289.8 Adult Salivary Gland  (927.7) Adult Heart    74.025 Adult VirginFemale Spermatheca    428.5 Adult InseminatedFemale Spermatheca  571.7 Adult Ovary    39.8 Adult Testis    37.9 Adult Male Accessory Gland  (873.4) Adult Carcass    70.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    58.875 Larval Midgut    242.4 Larval Hindgut    209.4 Larval Malpighian Tubules    80.4 Larval Fat Body    154.3 Larval Salivary Gland  (1953.4) Larval Trachea    132.2 Larval Carcass    267.575 Adult Head    95.1 Adult Eye    46.875 Adult Brain    37.9 Adult Thoracic-Abdominal Ganglion    36.5 Adult Crop    95.4 Adult Midgut    188.9 Adult Hindgut    91 Adult Malpighian Tubules    96.6 Adult Fat Body    289.8 Adult Salivary Gland    927.7 Adult Heart    74.025 Adult VirginFemale Spermatheca    428.5 Adult InseminatedFemale Spermatheca    571.7 Adult Ovary    39.8 Adult Testis    37.9 Adult Male Accessory Gland    873.4 Adult Carcass    70.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    58.875 Larval Midgut    242.4 Larval Hindgut    209.4 Larval Malpighian Tubules    80.4 Larval Fat Body    154.3 Larval Salivary Gland    1953.4 Larval Trachea    132.2 Larval Carcass    267.575 Adult Head    95.1 Adult Eye    46.875 Adult Brain    37.9 Adult Thoracic-Abdominal Ganglion    36.5 Adult Crop    95.4 Adult Midgut    188.9 Adult Hindgut    91 Adult Malpighian Tubules    96.6 Adult Fat Body    289.8 Adult Salivary Gland    927.7 Adult Heart    74.025 Adult VirginFemale Spermatheca    428.5 Adult InseminatedFemale Spermatheca    571.7 Adult Ovary    39.8 Adult Testis    37.9 Adult Male Accessory Gland    873.4 Adult Carcass    70.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    95.1   NA  Eye    46.875   NA  Brain    37.9   58.875  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    36.5   NA  Crop    95.4   242.4  Midgut    188.9   209.4  Hindgut    91   80.4  Malpighian Tubules    96.6   154.3  Fat Body    289.8   1953.4  Salivary Gland    927.7   NA  Heart    74.025   132.2  Trachea    NA   NA  VirginFemale Spermatheca    428.5   NA  InseminatedFemale Spermatheca    571.7   NA  Ovary    39.8   NA  Testis    37.9   NA  Male Accessory Gland    873.4   267.575  Carcass    70.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    29 central nervous system, larvae L3    14 central nervous system, pupae P8    8 head, virgin 1-day female    14 head, virgin 4-day female    9 head, virgin 20-day female    12 head, mated 1-day female    9 head, mated 4-day female    20 head, mated 20-day female    13 head, mated 1-day male    6 head, mated 4-day male    9 head, mated 20-day male    7 salivary gland, larvae L3 wandering    43 salivary gland, white prepupae    285 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    13 digestive system, 4-day adult    18 digestive system, 20-day adult    10 fat body, larvae L3 wandering    11 fat body, white prepupae    12 fat body, pupae P8    19 carcass, larvae L3 wandering    26 carcass, 1-day adult    16 carcass, 4-day adult    21 carcass, 20-day adult    16 ovary, virgin 4-day female    3 ovary, mated 4-day female    3 testis, mated 4-day male    4 accessory gland, mated 4-day male    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (29) central nervous system, larvae L3    14 central nervous system, pupae P8    8 head, virgin 1-day female    14 head, virgin 4-day female    9 head, virgin 20-day female    12 head, mated 1-day female    9 head, mated 4-day female    20 head, mated 20-day female    13 head, mated 1-day male    6 head, mated 4-day male    9 head, mated 20-day male    7 salivary gland, larvae L3 wandering  (43) salivary gland, white prepupae  (285) digestive system, larvae L3 wandering    10 digestive system, 1-day adult    13 digestive system, 4-day adult    18 digestive system, 20-day adult    10 fat body, larvae L3 wandering    11 fat body, white prepupae    12 fat body, pupae P8    19 carcass, larvae L3 wandering  26 carcass, 1-day adult    16 carcass, 4-day adult    21 carcass, 20-day adult    16 ovary, virgin 4-day female    3 ovary, mated 4-day female    3 testis, mated 4-day male    4 accessory gland, mated 4-day male  (27) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    29 central nervous system, larvae L3    14 central nervous system, pupae P8    8 head, virgin 1-day female    14 head, virgin 4-day female    9 head, virgin 20-day female    12 head, mated 1-day female    9 head, mated 4-day female    20 head, mated 20-day female    13 head, mated 1-day male    6 head, mated 4-day male    9 head, mated 20-day male    7 salivary gland, larvae L3 wandering    43 salivary gland, white prepupae  (285) digestive system, larvae L3 wandering    10 digestive system, 1-day adult    13 digestive system, 4-day adult    18 digestive system, 20-day adult    10 fat body, larvae L3 wandering    11 fat body, white prepupae    12 fat body, pupae P8    19 carcass, larvae L3 wandering    26 carcass, 1-day adult    16 carcass, 4-day adult    21 carcass, 20-day adult    16 ovary, virgin 4-day female    3 ovary, mated 4-day female    3 testis, mated 4-day male    4 accessory gland, mated 4-day male    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    29 central nervous system, larvae L3    14 central nervous system, pupae P8    8 head, virgin 1-day female    14 head, virgin 4-day female    9 head, virgin 20-day female    12 head, mated 1-day female    9 head, mated 4-day female    20 head, mated 20-day female    13 head, mated 1-day male    6 head, mated 4-day male    9 head, mated 20-day male    7 salivary gland, larvae L3 wandering    43 salivary gland, white prepupae    285 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    13 digestive system, 4-day adult    18 digestive system, 20-day adult    10 fat body, larvae L3 wandering    11 fat body, white prepupae    12 fat body, pupae P8    19 carcass, larvae L3 wandering    26 carcass, 1-day adult    16 carcass, 4-day adult    21 carcass, 20-day adult    16 ovary, virgin 4-day female    3 ovary, mated 4-day female    3 testis, mated 4-day male    4 accessory gland, mated 4-day male    27 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    29 central nervous system, larvae L3    14 central nervous system, pupae P8    8 head, virgin 1-day female    14 head, virgin 4-day female    9 head, virgin 20-day female    12 head, mated 1-day female    9 head, mated 4-day female    20 head, mated 20-day female    13 head, mated 1-day male    6 head, mated 4-day male    9 head, mated 20-day male    7 salivary gland, larvae L3 wandering    43 salivary gland, white prepupae    285 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    13 digestive system, 4-day adult    18 digestive system, 20-day adult    10 fat body, larvae L3 wandering    11 fat body, white prepupae    12 fat body, pupae P8    19 carcass, larvae L3 wandering    26 carcass, 1-day adult    16 carcass, 4-day adult    21 carcass, 20-day adult    16 ovary, virgin 4-day female    3 ovary, mated 4-day female    3 testis, mated 4-day male    4 accessory gland, mated 4-day male    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  29 central nervous system, larvae L3    14 central nervous system, pupae P8    8 head, virgin 1-day female    14 head, virgin 4-day female    9 head, virgin 20-day female    12 head, mated 1-day female    9 head, mated 4-day female    20 head, mated 20-day female    13 head, mated 1-day male    6 head, mated 4-day male    9 head, mated 20-day male    7 salivary gland, larvae L3 wandering  (43) salivary gland, white prepupae  (285) digestive system, larvae L3 wandering    10 digestive system, 1-day adult    13 digestive system, 4-day adult    18 digestive system, 20-day adult    10 fat body, larvae L3 wandering    11 fat body, white prepupae    12 fat body, pupae P8    19 carcass, larvae L3 wandering  26 carcass, 1-day adult    16 carcass, 4-day adult    21 carcass, 20-day adult    16 ovary, virgin 4-day female    3 ovary, mated 4-day female    3 testis, mated 4-day male    4 accessory gland, mated 4-day male  27 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    29 central nervous system, larvae L3    14 central nervous system, pupae P8    8 head, virgin 1-day female    14 head, virgin 4-day female    9 head, virgin 20-day female    12 head, mated 1-day female    9 head, mated 4-day female    20 head, mated 20-day female    13 head, mated 1-day male    6 head, mated 4-day male    9 head, mated 20-day male    7 salivary gland, larvae L3 wandering    43 salivary gland, white prepupae  (285) digestive system, larvae L3 wandering    10 digestive system, 1-day adult    13 digestive system, 4-day adult    18 digestive system, 20-day adult    10 fat body, larvae L3 wandering    11 fat body, white prepupae    12 fat body, pupae P8    19 carcass, larvae L3 wandering    26 carcass, 1-day adult    16 carcass, 4-day adult    21 carcass, 20-day adult    16 ovary, virgin 4-day female    3 ovary, mated 4-day female    3 testis, mated 4-day male    4 accessory gland, mated 4-day male    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    29 central nervous system, larvae L3    14 central nervous system, pupae P8    8 head, virgin 1-day female    14 head, virgin 4-day female    9 head, virgin 20-day female    12 head, mated 1-day female    9 head, mated 4-day female    20 head, mated 20-day female    13 head, mated 1-day male    6 head, mated 4-day male    9 head, mated 20-day male    7 salivary gland, larvae L3 wandering    43 salivary gland, white prepupae    285 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    13 digestive system, 4-day adult    18 digestive system, 20-day adult    10 fat body, larvae L3 wandering    11 fat body, white prepupae    12 fat body, pupae P8    19 carcass, larvae L3 wandering    26 carcass, 1-day adult    16 carcass, 4-day adult    21 carcass, 20-day adult    16 ovary, virgin 4-day female    3 ovary, mated 4-day female    3 testis, mated 4-day male    4 accessory gland, mated 4-day male    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-18 hour embryonic stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    4 embryo 04-06hr    16 embryo 06-08hr    25 embryo 08-10hr    30 embryo 10-12hr    25 embryo 12-14hr    37 embryo 14-16hr    19 embryo 16-18hr    10 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    7 larva L2    16 larva L3 12hr old    11 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    16 white prepupae new    29 white prepupae 12hr    5 white prepupae 24hr    9 pupae 2d postWPP    16 pupae 3d postWPP    6 pupae 4d postWPP    3 adult male 01day    9 adult male 05day    8 adult male 30day    8 adult female 01day    5 adult female 05day    6 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    4 embryo 04-06hr    16 embryo 06-08hr    25 embryo 08-10hr  (30) embryo 10-12hr    25 embryo 12-14hr  (37) embryo 14-16hr    19 embryo 16-18hr    10 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    7 larva L2    16 larva L3 12hr old    11 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    16 white prepupae new  (29) white prepupae 12hr    5 white prepupae 24hr    9 pupae 2d postWPP    16 pupae 3d postWPP    6 pupae 4d postWPP    3 adult male 01day    9 adult male 05day    8 adult male 30day    8 adult female 01day    5 adult female 05day    6 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    4 embryo 04-06hr    16 embryo 06-08hr    25 embryo 08-10hr    30 embryo 10-12hr    25 embryo 12-14hr    37 embryo 14-16hr    19 embryo 16-18hr    10 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    7 larva L2    16 larva L3 12hr old    11 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    16 white prepupae new    29 white prepupae 12hr    5 white prepupae 24hr    9 pupae 2d postWPP    16 pupae 3d postWPP    6 pupae 4d postWPP    3 adult male 01day    9 adult male 05day    8 adult male 30day    8 adult female 01day    5 adult female 05day    6 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    4 embryo 04-06hr    16 embryo 06-08hr    25 embryo 08-10hr    30 embryo 10-12hr    25 embryo 12-14hr    37 embryo 14-16hr    19 embryo 16-18hr    10 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    7 larva L2    16 larva L3 12hr old    11 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    16 white prepupae new    29 white prepupae 12hr    5 white prepupae 24hr    9 pupae 2d postWPP    16 pupae 3d postWPP    6 pupae 4d postWPP    3 adult male 01day    9 adult male 05day    8 adult male 30day    8 adult female 01day    5 adult female 05day    6 adult female 30day    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    4 embryo 04-06hr    16 embryo 06-08hr    25 embryo 08-10hr    30 embryo 10-12hr    25 embryo 12-14hr    37 embryo 14-16hr    19 embryo 16-18hr    10 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    7 larva L2    16 larva L3 12hr old    11 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    16 white prepupae new    29 white prepupae 12hr    5 white prepupae 24hr    9 pupae 2d postWPP    16 pupae 3d postWPP    6 pupae 4d postWPP    3 adult male 01day    9 adult male 05day    8 adult male 30day    8 adult female 01day    5 adult female 05day    6 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    4 embryo 04-06hr    16 embryo 06-08hr    25 embryo 08-10hr  30 embryo 10-12hr    25 embryo 12-14hr  (37) embryo 14-16hr    19 embryo 16-18hr    10 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    7 larva L2    16 larva L3 12hr old    11 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    16 white prepupae new  29 white prepupae 12hr    5 white prepupae 24hr    9 pupae 2d postWPP    16 pupae 3d postWPP    6 pupae 4d postWPP    3 adult male 01day    9 adult male 05day    8 adult male 30day    8 adult female 01day    5 adult female 05day    6 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    4 embryo 04-06hr    16 embryo 06-08hr    25 embryo 08-10hr    30 embryo 10-12hr    25 embryo 12-14hr    37 embryo 14-16hr    19 embryo 16-18hr    10 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    7 larva L2    16 larva L3 12hr old    11 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    16 white prepupae new    29 white prepupae 12hr    5 white prepupae 24hr    9 pupae 2d postWPP    16 pupae 3d postWPP    6 pupae 4d postWPP    3 adult male 01day    9 adult male 05day    8 adult male 30day    8 adult female 01day    5 adult female 05day    6 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    4 embryo 04-06hr    16 embryo 06-08hr    25 embryo 08-10hr    30 embryo 10-12hr    25 embryo 12-14hr    37 embryo 14-16hr    19 embryo 16-18hr    10 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    7 larva L2    16 larva L3 12hr old    11 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    16 white prepupae new    29 white prepupae 12hr    5 white prepupae 24hr    9 pupae 2d postWPP    16 pupae 3d postWPP    6 pupae 4d postWPP    3 adult male 01day    9 adult male 05day    8 adult male 30day    8 adult female 01day    5 adult female 05day    6 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4    38 embryonic 1182-4H    15 embryonic GM2    48 embryonic Kc167    20 embryonic S1    8 embryonic S3    19 leg disc CME L1    42 wing disc CME-W2    17 wing disc ML-DmD8    12 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    35 wing disc ML-DmD21    2 wing disc ML-DmD32    30 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    21 tumorous blood cells mbn2    53 ovary fGS/OSS    2 ovary OSC    2 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4  (38) embryonic 1182-4H    15 embryonic GM2  (48) embryonic Kc167    20 embryonic S1    8 embryonic S3    19 leg disc CME L1  (42) wing disc CME-W2    17 wing disc ML-DmD8    12 wing disc ML-DmD9    9 wing disc ML-DmD16-c3  (35) wing disc ML-DmD21    2 wing disc ML-DmD32  (30) haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    21 tumorous blood cells mbn2  (53) ovary fGS/OSS    2 ovary OSC    2 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4    38 embryonic 1182-4H    15 embryonic GM2    48 embryonic Kc167    20 embryonic S1    8 embryonic S3    19 leg disc CME L1    42 wing disc CME-W2    17 wing disc ML-DmD8    12 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    35 wing disc ML-DmD21    2 wing disc ML-DmD32    30 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    21 tumorous blood cells mbn2    53 ovary fGS/OSS    2 ovary OSC    2 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4    38 embryonic 1182-4H    15 embryonic GM2    48 embryonic Kc167    20 embryonic S1    8 embryonic S3    19 leg disc CME L1    42 wing disc CME-W2    17 wing disc ML-DmD8    12 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    35 wing disc ML-DmD21    2 wing disc ML-DmD32    30 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    21 tumorous blood cells mbn2    53 ovary fGS/OSS    2 ovary OSC    2 ovary OSS    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4    38 embryonic 1182-4H    15 embryonic GM2    48 embryonic Kc167    20 embryonic S1    8 embryonic S3    19 leg disc CME L1    42 wing disc CME-W2    17 wing disc ML-DmD8    12 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    35 wing disc ML-DmD21    2 wing disc ML-DmD32    30 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    21 tumorous blood cells mbn2    53 ovary fGS/OSS    2 ovary OSC    2 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4  (38) embryonic 1182-4H    15 embryonic GM2  (48) embryonic Kc167    20 embryonic S1    8 embryonic S3    19 leg disc CME L1  (42) wing disc CME-W2    17 wing disc ML-DmD8    12 wing disc ML-DmD9    9 wing disc ML-DmD16-c3  (35) wing disc ML-DmD21    2 wing disc ML-DmD32  30 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    21 tumorous blood cells mbn2  (53) ovary fGS/OSS    2 ovary OSC    2 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4    38 embryonic 1182-4H    15 embryonic GM2    48 embryonic Kc167    20 embryonic S1    8 embryonic S3    19 leg disc CME L1    42 wing disc CME-W2    17 wing disc ML-DmD8    12 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    35 wing disc ML-DmD21    2 wing disc ML-DmD32    30 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    21 tumorous blood cells mbn2    53 ovary fGS/OSS    2 ovary OSC    2 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4    38 embryonic 1182-4H    15 embryonic GM2    48 embryonic Kc167    20 embryonic S1    8 embryonic S3    19 leg disc CME L1    42 wing disc CME-W2    17 wing disc ML-DmD8    12 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    35 wing disc ML-DmD21    2 wing disc ML-DmD32    30 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    21 tumorous blood cells mbn2    53 ovary fGS/OSS    2 ovary OSC    2 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    11 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    11 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    11 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    11 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    11 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    11 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    11 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    11 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_25 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	BDGP expression data • RE64328 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004396 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • HDC10294;CG7450-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CrebA Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL432B CrebAScer\UAS.cRa lethal, with Scer\GAL435 CrebAScer\UAS.cRa lethal, with Scer\GAL4128 CrebAScer\UAS.cRa lethal, with Scer\GAL4202 CrebAScer\UAS.cRa lethal, with Scer\GAL4323 CrebAScer\UAS.cRa lethal, with Scer\GAL4h-1J3 CrebAScer\UAS.cRa lethal | embryonic stage | recessive CrebArR3-4 CrebArR7 lethal | larval stage | recessive CrebA03576 CrebArR5 CrebArR7 CrebAwR11 CrebAwR23 CrebAwR83 CrebAwR84 lethal | recessive CrebA03576 CrebArR5 CrebArR9 CrebAwR11 CrebAwR23 CrebAwR83 CrebAwR84 partially lethal - majority die CrebA03576 viable CrebAEY15124 CrebArR34 CrebAwR3 CrebAwR7 CrebAwR13 Sterility Allele fertile CrebAEY15124 Other Phenotypes Allele visible, with Scer\GAL4ey.PH CrebAScer\UAS.cRa visible, with Scer\GAL4GMR.PF CrebAScer\UAS.cRa visible | somatic clone CrebAunspecified Phenotype manifest in Allele denticle belt | larval stage CrebA03576 CrebArR5 CrebArR7 CrebAwR11 CrebAwR23 CrebAwR83 CrebAwR84 embryonic/larval cuticle CrebA03576 CrebArR5 CrebArR7 CrebAwR11 CrebAwR23 CrebAwR83 CrebAwR84 embryonic/larval salivary gland CrebAwR23 eye | ectopic, with Scer\GAL4ey.PH CrebAScer\UAS.cRa eye photoreceptor cell | somatic clone CrebAunspecified larva CrebA03576 CrebArR5 CrebArR7 CrebAwR11 CrebAwR23 CrebAwR83 CrebAwR84 ommatidium, with Scer\GAL4ey.PH CrebAScer\UAS.cRa ommatidium, with Scer\GAL4GMR.PF CrebAScer\UAS.cRa ommatidium | somatic clone CrebAunspecified
Classical Alleles ( 22 )
For All Classical Alleles Show
Allele of CrebA Class Mutagen Stocks Known lesion CrebA03576 loss of function allele P-element activity 1 Yes CrebAEY13494 P-element activity 1 -- CrebAEY15124 P-element activity 1 -- CrebAf01773 piggyBac transposase 1 -- CrebAf05198 piggyBac transposase 1 -- CrebAf06165 piggyBac transposase 1 -- CrebAMI01429 1 -- CrebAMI06441 1 -- CrebArR9 Delta2-3 1 Yes CrebAf07184 piggyBac transposase 0 -- CrebArR3-4 gamma ray 0 Yes CrebArR34 0 Yes CrebArR5 loss of function allele P-element activity Delta2-3 0 Yes CrebArR7 loss of function allele P-element activity Delta2-3 0 Yes CrebAunspecified 0 -- CrebAwR11 loss of function allele P-element activity 0 Yes CrebAwR13 0 Yes CrebAwR23 loss of function allele P-element activity 0 Yes CrebAwR3 0 Yes CrebAwR7 0 Yes CrebAwR83 loss of function allele P-element activity 0 Yes CrebAwR84 loss of function allele P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CrebA Class Mutagen Stocks Known lesion CrebAHMJ02218 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CrebAJF02189 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CrebAJF02823 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CrebAScer\UAS.cRa in vitro construct - regulatory fusion 1 Yes CrebAGD1725 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes CrebAKK108357 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)BK10 (Andrew et al., 1997, Rose et al., 1997) Df(3L)BSC442 (Christensen et al., 2008.4.15) Df(3L)fz-M21 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(3L)rR1-4 (Rose et al., 1997) Df(3L)rR2-4 (Rose et al., 1997) Df(3L)rR4-4 (Rose et al., 1997) Df(3L)st-f13 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(3L)wR1 (Rose et al., 1997) Ts(1Lt;3Rt)sc260-15+Ts(2Lt;3Lt)514.2-2-192+Ts(2Rt;3Rt)DTD61 (Rose et al., 1997)
Not disrupted in	Df(3L)Brd15 (Rose et al., 1997)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data reporter construct P{CrebA-lacZ.0.77} No P{CrebA-lacZ.1.1.fkh1-6} No P{CrebA-lacZ.1.1} No P{CrebA-lacZ.2.8} No UAS construct P{GD1725} NA P{KK108357} NA P{TRiP.HMJ02218} NA P{TRiP.JF02189} NA P{TRiP.JF02823} NA P{UAS-CrebA.R} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}B204 No P{PZ}CrebA03576 No insertion of mobile activating element P{EPgy2}CrebAEY13494 NA P{EPgy2}CrebAEY15124 NA miscellaneous insertions Mi{MIC}CrebAMI01429 NA Mi{MIC}CrebAMI06441 NA P{?'lacW}CrebAwR83 NA P{?'PZ}CrebArR9 NA P{GT1}BG01366 NA P{PZ-ΔrR3-4}CrebArR3-4 NA P{PZ-ΔrR5}CrebArR5 NA P{PZ-ΔrR7}CrebArR7 NA PBac{WH}CrebAf01773 NA PBac{WH}CrebAf05198 NA PBac{WH}CrebAf06165 NA PBac{WH}CrebAf07184 NA
Gene Ontology: Function, Process & Cellular Component ( 14 unique terms )
Terms Based on Experimental Evidence ( 11 terms )
Molecular Function
CV term Evidence References
DNA binding inferred from direct assay (Abel et al., 1992) enhancer sequence-specific DNA binding inferred from direct assay (Fox et al., 2010) sequence-specific DNA binding inferred from direct assay (Smolik-Utlaut et al., 1992) sequence-specific DNA binding transcription factor activity inferred from direct assay (Smolik-Utlaut et al., 1992)
Biological Process
CV term Evidence References
chitin-based larval cuticle pattern formation inferred from mutant phenotype (Andrew et al., 1997, Abrams and Andrew, 2005) dorsal/ventral pattern formation inferred from genetic interaction with dpp (Andrew et al., 1997) larval chitin-based cuticle development inferred from mutant phenotype (Abrams and Andrew, 2005) positive regulation of transcription, DNA-dependent inferred from mutant phenotype (Fox et al., 2010) positive regulation of transcription from RNA polymerase II promoter inferred from direct assay (Smolik-Utlaut et al., 1992) salivary gland development inferred from mutant phenotype (Andrew et al., 1997)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Abel et al., 1992, Jattani et al., 2009)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
DNA binding non-traceable author statement (Swiss-Prot Project Members, 1993.4.1) protein homodimerization activity inferred from sequence or structural similarity (Fassler et al., 2002) sequence-specific DNA binding transcription factor activity non-traceable author statement (Swiss-Prot Project Members, 1993.4.1)
Biological Process
CV term Evidence References
salivary gland development traceable author statement (Abrams et al., 2003) salivary gland morphogenesis non-traceable author statement (Bradley et al., 2001) transcription from RNA polymerase II promoter non-traceable author statement (Swiss-Prot Project Members, 1993.4.1)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (Swiss-Prot Project Members, 1993.4.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CrebA - 128up anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - ACC anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - AP-2α anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - ATPsyn-γ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - Aats-lys anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - Arc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - Atx2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - BCAS2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - CG10077 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - CG10306 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - CG11563 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - CG12264 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - CG13472 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - CG15220 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - CG15735 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - CG3224 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - CG3262 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - CG3689 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - CG3800 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - CG4849 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - CG5214 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - CG7182 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - CG7878 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - CG8043 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - CG8142 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - CG9062 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - Cdc5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - CkIα anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - Dgp-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - DnaJ-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - Dp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - Eb1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - EfTuM anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - Gnf1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - Hcf anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - Irbp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - Ku80 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - Lon anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - Map205 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - NHP2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - Ns1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - Ote anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - Pgam5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - Rbp1-like anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - RpL35A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - RpS10b anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - RpS19a anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - RpS19b anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - Rrp46 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - Rsf1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - Saf-B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - Ski6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - SmD3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - ago anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - ctp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - eIF-2β anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - eIF-4B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - hts anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - kst anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - l(1)G0230 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - l(2)35Df anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - l(3)72Ab anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - mRpL54 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - mbf1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - pav anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - pit anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - polo anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - skpA anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - tsu anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - tyf anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - vig anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - ytr anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrebA - εCOP anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CrebA allele Gene References unspecified nej (Anderson et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65001 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0004396 DroID - A comprehensive database of gene and protein interactions. • FBgn0004396 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39682 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P29747
Orthologs
OrthoDB Orthologs (31) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6549JH Dipteran inclusive ortholog search EOG6X6CHZ Insect inclusive ortholog search EOG6DJHS3 Arthropod inclusive ortholog search EOG6DR7TZ Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6549JH)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CrebA     Drosophila simulans   Dsim\GD14552 Y   Drosophila sechellia   Dsec\GM25536 Y   Drosophila erecta   Dere\GG15906 Y   Drosophila yakuba   Dyak\GE22248 Y   Drosophila ananassae   Dana\GF10055 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA20362 Y   Drosophila persimilis   Dper\GL24866 Y   Drosophila willistoni   Dwil\GK10597 Y   Drosophila virilis   Dvir\GJ13865 Y   Drosophila mojavensis   Dmoj\GI13117 Y   Drosophila grimshawi   Dgri\GH14739 Y
Orthologs in non-Drosophila Dipterans (EOG6X6CHZ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL000402   Anopheles gambiae Malaria mosquito  Agam\AGAP011038   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ003369
Orthologs in non-Dipteran Insects (EOG6DJHS3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB47941   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG009270   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH11154   Atta cephalotes Leafcutter ant  Acep\ACEP27545   Atta cephalotes Leafcutter ant  Acep\ACEP19878   Camponotus floridanus Florida carpenter ant  Cflo\CFLO11335   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15578   Linepithema humile Argentine ant  Lhum\LH20779   Pogonomyrmex barbatus Red harvester ant  Pbar\PB20390   Solenopsis invicta Red fire ant  Sinv\SINV21499   Acyrthosiphon pisum Pea aphid  Apim\ACYPI005068   Bombyx mori Silkmoth  Bmor\BGIBMGA000874   Pediculus humanus Human body louse  Phum\PHUM261390   Tribolium castaneum Red flour beetle  Tcas\TC011118
Orthologs in non-Insect Arthropods (EOG6DR7TZ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\rbcL   Ixodes scapularis Deer tick  Isca\ISCW008037
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD14552 Drosophila sechellia Dsec\GM25536 Drosophila erecta Dere\GG15906 Drosophila yakuba Dyak\GE22248 Drosophila ananassae Dana\GF10055 Drosophila pseudoobscura pseudoobscura Dpse\GA20362 Drosophila persimilis Dper\GL24866 Drosophila willistoni Dwil\GK10597 Drosophila virilis Dvir\GJ13865 Drosophila mojavensis Dmoj\GI13117 Drosophila grimshawi Dgri\GH14739
Stocks & Reagents
Stocks Listed in FlyBase ( 12 )
Bloomington	27648 y1 v1; P{TRiP.JF02823}attP2 31900 y1 v1; P{TRiP.JF02189}attP2 42562 y1 v1; P{TRiP.HMJ02218}attP40 20970 y1 w67c23; P{EPgy2}CrebAEY15124 32572 w*; P{UAS-CrebA.R}Tr11; CrebArR9/TM6B, Tb1 34195 y1 w*; Mi{MIC}CrebAMI01429/TM3, Sb1 Ser1 44167 y1 w*; Mi{MIC}CrebAMI06441/TM3, Sb1 Ser1 21095 y1 w67c23; P{EPgy2}CrebAEY13494/TM3, Sb1 Ser1 10183 P{PZ}CrebA03576 ry506/TM3, P{ftz/lacC}SC1, ryRK Sb1 Ser1
Harvard	- PBac{WH}CrebAf01773 - PBac{WH}CrebAf05198 - PBac{WH}CrebAf06165
Genomic Clones ( 2 )
	BACR07L07 BACR09C21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 145 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE64328 SD05937 SD14261
Other clones	DPiM_FI01021 FI01021
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP12457 RE54414 SD22078
Other clones	476 1382 14430 15762 15826 38057 41874 44849 65091 70547 74807 76640 76943 84286 154792 165978 178860 214285.49 214499.56 275337 283317 CK01.10A.E8 CK01.49C.A6 CK01.54A.E8 CK01.55D.G11 CK01.124D.F5 CK01270 EC23951 EC35918 EK041135 EK044052 EK044726 EK045426 EK094823 EK121461 EK122551 EK139901 EK160250 EK174334 EK174515 EK191825 EK197406 EK197935 EK204946 EK206611 EK276605 EK303230 EK308034 EK308802 EN17206 EP10352 EP18823 FGM221B08 RP003004108 RP003009109 RP003018211 RP003066958 RP003072601 RP003090931 RP003106165 RP003118873 RP003125941 RP003132616 RP003162127 RP003180415 RP003185333 RP003187674 RP003194663 RP003196992 RP003197674 RP003211931 RP003253402 RP003257903 RP003263949 RP003267257 RP003269629 RP003276172 RP003283910 RP003292999 RP003300749 RP003302971 RP003305992 RP003308415 RP003346090 RP003350586 RP003359983 RP003375793 RP003380429 RP003401803 RP003453225 RP003459615 RP003462470 RP003471445 RP003496607 RP003510672 RP003513329 RP003518045 RP003521832 RP003524529 RP003532044 RP003543781 RP003566529 RP003587663 RP003614412 RP003622930 RP003624616 RP003632323 RP003682054 RP004069947 RP004081594 RP004094911 RP004130470 RP004158317 RP004163415 RP004215020 RP004216198 RP004219706 RP004223374 RP004224467 RP004229301 RP004245583 RP004255203 RP004257975 RP004307315 RP004324891 RP004349750 RP004400502 RP004417400 RP004420280 RP004477821 RP004483122 RP004499751 RP004501547 RP004526066 RP004530296 RP004541580 RP004550114
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004396 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39682
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CrebA Bbbf2 (FlyBase, 1996-) Source for merge of: CrebA BcDNA:SD05937 (FlyBase, 1996-)
Additional comments	Source for merge of CrebA BcDNA:SD05937 was a shared cDNA (date:030728). (FlyBase, 1996-) Source for merge of CrebA Bbbf2 was sequence comparison (date:000202). (FlyBase, 1996-)
Other Comments
	CrebA protein binds to the copia ULR (untranslated leader region). (Wilson et al., 1998) In the epidermis CrebA is required for patterning cuticular structures on both the dorsal and ventral surfaces of larvae, mutant larvae have only lateral structures around the entire circumference of each segment. Epistasis tests with known dorsal/ventral patterning genes suggests that CrebA encodes a transcription factor near the end of both the dpp and spi signalling cascades to translate the corresponding extracellular signals into changes in gene expression. Double mutants with segment polarity genes confirm that CrebA is not involved in segment polarity. (Andrew et al., 1997) The genomic organisation of the CrebA locus has been characterised, and its expression pattern has been analysed. (Rose et al., 1997) CrebA mutants display lateralisation of the larval cuticle and the cuticle is significantly weaker than wild type larval cuticle. The salivary gland and tracheae display a 'crooked' phenotype. (Andrew et al., 1995) CrebA protein binds to the fat body specific enhancers of Dmul\Adh1, Adh, Yp1 and Yp2 and may be an important component of tissue specific regulation. (Abel et al., 1992) Isolation and characterization of Creb reveals that the protein binds to the CRE sequence and belongs to the leucine zipper family of transcription factors. (Smolik-Utlaut et al., 1992)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079363 NM_206374 RefSeq (Proteins) • NP_524087 NP_996096 DDBJ / EMBL / GenBank • AAA28427 AAF49621 AAM52763 AAS64997 AAX33391 AI541662 AQ034057 AW944445 AY122251 BG636528 BT021243 CAA45771 CL943677 CZ484246 CZ484247 CZ487823 CZ488815 CZ489984 G00569 M87038 X64429 Entrez Gene - A searchable database of RefSeq genes. • 39682 UniProtKB/Swiss-Prot • P29747 UniProtKB/TrEMBL • Q1LZ07 Q5BII1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Basic-leucine zipper domain (IPR004827) Eukaryotic transcription factor, Skn-1-like, DNA-binding (IPR008917) cAMP response element binding (CREB) protein (IPR001630) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE64328
Linkouts
	BioGRID - A database of protein and genetic interactions • 65001 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0004396 DroID - A comprehensive database of gene and protein interactions. • FBgn0004396 DRSC - Results from RNAi screens. • FBgn0004396 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004396 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • HDC10294;CG7450-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004396 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39682 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /dbzhnsky/dcreba1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39682 modMine - Data generated by the modENCODE project. • FBgn0004396 REDfly - A database of transcriptional regulatory elements. • FBgn0004396 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P29747
Synonyms & Secondary IDs ( 27 )
Reported As
Symbol Synonym	Bbbf2   BBF-2 (Wilson et al., 1998, Sondergaard, 1993, Abel et al., 1992) BBF2_DROME (Bornberg-Bauer et al., 1998) BcDNA:SD05937   BOX B Binding Factor-2 (Abel, 1992.2.12) CG7450 (Quinones-Coello, 2007, Perkins et al., 2009, Keleman et al., 2009.8.5, Ni et al., 2010.12.1) CREB (Orian, 2006, Zhang and Broadie, 2005, Chandrasekaran and Beckendorf, 2003, Morley and Montgomery, 2001, Dubnau et al., 2003, Sanyal et al., 2003, Wells, 2001, Jan, 2000, Massague and Wotton, 2000, Davis, 2000, De Cesare et al., 1999, Schuster et al., 1997, Goodman, 1997, Gellon and McGinnis, 1998, Abel et al., 1998, Singh et al., 1995, Goda, 1995, de Belle, 1995, Wang et al., 2006, Iijima-Ando and Iijima, 2007, Bhaskara et al., 2006, Davis, 2004, Lin et al., 2008) Creb (Grienenberger et al., 2000, ) creb (Koushika et al., 2000) CREB-a (Cooke and Bliss, 2003, Broadie, 1998) CREB-A (Kockel et al., 2001) crebA (Fassler et al., 2002, Jiang and Crews, 2006, Tsurudome et al., 2010) Creb-A (Andrew et al., 1995, Smolik-Utlaut et al., 1992) CrebA (Abrams et al., 2006, Stark et al., 2005, Fox et al., 2010, Meyer et al., 2006, Quinones-Coello, 2007, Maruyama et al., 2011, Fox et al., 2008, Christensen et al., 2008.4.15, Stark et al., 2007, Wang and Lin, 2007, Greene et al., 2005, Gim et al., 2001, Chung et al., 2009, Kheradpour et al., 2007, Tang et al., 2010, Burgler and Macdonald, 2005, Tsurudome et al., 2010, Obbard et al., 2011, Shaik et al., 2011, Skora and Spradling, 2010, Mizrak et al., 2012) Creb A (Liu et al., 2009) CREBA (modENCODE Consortium et al., 2010) CRE-BP (Bhaskara et al., 2006) dCREBA (Nikolaidou, 2004, Nikolaidou and Barrett, 2004, Whalen and Simon, 2001) dCreb-A (Abrams and Andrew, 2003, Torres-Vazquez et al., 2001, Isaac and Andrew, 1996, Maybeck and Röper, 2009, Jattani et al., 2009, Papadopoulos et al., 2012) dCREB-A (Bradley et al., 2003, Abrams et al., 2003, Myat and Andrew, 2002, Seshaiah et al., 2001, Bradley et al., 2001, Bradley and Andrew, 2001, Myat and Andrew, 2000, Hewes et al., 2000, Andrew et al., 2000, Abrams and Andrew, 2000, Henderson and Andrew, 2000, Myat and Andrew, 2000, Henderson and Andrew, 2000, Seshaiah and Andrew, 1999, Holley et al., 1999, Abrams and Andrew, 1999, Henderson et al., 1999, Lu et al., 1998, Andrew, 1998, Rose et al., 1997, Eresh et al., 1997, Andrew et al., 1997, Smolik, 1996, Gallaher et al., 1993, Andrew et al., 1994, Usui et al., 1993, Poels et al., 2004, Wang et al., 2009, Pirraglia et al., 2006, Wang et al., 2007, Xu et al., 2008, Urbano et al., 2009, Papadopoulos et al., 2010, Papadopoulos et al., 2010) dCrebA (Nakamura et al., 2001, Joshi et al., 2007) l(3)03576
Name Synonym	Box B-binding factor 2   cAMP response element binding protein (Davis, 2004) cAMP response element binding protein A (Gim et al., 2001) cyclic AMP response element binding protein (Bhaskara et al., 2006) Cyclic-AMP response element binding protein A (Wang and Lin, 2007, Harbison et al., 2005) dCREB-A (Poels et al., 2004)
Secondary FlyBase IDs
	FBgn0004848 FBgn0010804 FBgn0041115 FBgn0062892
References ( 138 )
Generate a list of	All references relating to this gene ( 138 )
List References by type	Research paper  ( 70 ) Supplementary material  ( 8 ) Review  ( 18 ) Personal communication to FlyBase  ( 13 ) Abstract  ( 20 ) FlyBase analysis  ( 2 ) Book review  ( 1 ) DNA/RNA sequence record  ( 1 ) Letter  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 6 )
	Barbosa et al., 2013, Traffic 14(4): 382--398 An Orchestrated Program Regulating Secretory Pathway Genes and Cargos by the Transmembrane Transcription Factor CREB-H. [FBrf0221003] Mizrak et al., 2012, Curr. Biol. 22(20): 1871--1880 Electrical activity can impose time of day on the circadian transcriptome of pacemaker neurons. [FBrf0219786] Papadopoulos et al., 2012, Dev. Biol. 367(1): 78--89 Dimer formation via the homeodomain is required for function and specificity of Sex combs reduced in Drosophila. [FBrf0218494] Maruyama et al., 2011, PLoS ONE 6(6): e20901 Genome-Wide Analysis Reveals a Major Role in Cell Fate Maintenance and an Unexpected Role in Endoreduplication for the Drosophila FoxA Gene Fork Head. [FBrf0214025] Obbard et al., 2011, Mol. Biol. Evol. 28(2): 1043--1056 Recent and Recurrent Selective Sweeps of the Antiviral RNAi Gene Argonaute-2 in Three Species of Drosophila. [FBrf0212800] Shaik et al., 2011, Glycobiology 21(6): 743--756 The Alg5 ortholog Wollknäuel is essential for correct epidermal differentiation during Drosophila late embryogenesis. [FBrf0214472] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...