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Gene Dmel\tam

General Information
Symbol	Dmel\tam	Species	D. melanogaster
Name	tamas	Annotation symbol	CG8987
Feature type	protein_coding_gene	FlyBase ID	FBgn0004406
Gene Model Status	Current	Stock availability	11 publicly available
Also Known As	DNApol-γ125, l(2)34Dc, pol γ-α, DNApol-γ, l(2)br5, MtPolA, BG:DS00941.6, polγ
Genomic Location
Chromosome (arm)	2L	Recombination map	2-
Cytogenetic map	34D1-34D1	Sequence location	2L:13,823,980..13,827,793 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene tamas is referred to in FlyBase by the symbol Dmel\tam (CG8987, FBgn0004406). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: DNA-directed DNA polymerase activity. There is experimental evidence that it is involved in the biological process: DNA-dependent DNA replication. 22 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; adult segment; organ system; adult mesothoracic segment; sensillum; cytoplasmic part; nervous system; imaginal precursor; adult cuticle; external compound sense organ. It has one annotated transcript and one annotated polypeptide. Protein features are: DNA-directed DNA polymerase, family A, conserved site; DNA-directed DNA polymerase, family A, palm domain; DNA-directed DNA-polymerase, family A, mitochondria. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1637860_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of tam. Gene sequence location is 2L:13823980..13827793.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	l(2)34Dc l(2)34Dc3 produces about 1% escapers in heterozygous combination with both l(2)34Dc1 and l(2)34Dc2.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Matsushima et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(43): 18410--18415 Sequence features BKN20581 HFA03621
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 34D1-34D1   Limits computationally determined from genome sequence between P{lacW}Sosk05224&P{lacW}RpII33k05605 and P{lacW}l(2)34Fak00811&P{PZ}wb09437
Experimentally Determined Cytological Location
Cytogenetic map Notes References 34D-34E     (Kaguni, 1996.6.27) 34D-34E   (determined by in situ hybridisation)   (Lewis et al., 1996) 34D4-34D4     (Bonfini et al., 1992)
Experimentally Determined Recombination Data
Location	2- (Kaguni, 1996.6.27)
Left of (cM)
Right of (cM)
Notes	Deletion-mapped to between b and Sop2 or Orc5. (Ashburner et al., 1999)
Gene Model & Products
Please see the GBrowse view of Dmel\tam for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.41
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) tam-RA FBtr0080571  NM_057473   3700   1145
Additional Transcript Data & Comments
Reported size (kB)	3.7 (longest cDNA) (Lewis et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein tam-PA   FBpp0080148   129.8   1145   7.49     NP_476821   AAF53338
Additional Polypeptide Data & Comments
Reported size (kDa)	1145 (aa); 128.6 (kD predicted) (Lewis et al., 1996) 125 (kD) (Wernette et al., 1988, Wernette and Kaguni, 1986, Kaguni et al., 1988)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • DNA-directed DNA polymerase, family A, palm domain (IPR001098) DNA-directed DNA-polymerase, family A, mitochondria (IPR002297) DNA-directed DNA polymerase, family A, conserved site (IPR019760) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME08987
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA263336   AA538934   AA816552   AE014134 AAF53338   AC092223   AE003408 AAF44822   AI519712   AI530930   AI532074   AI533851   AI541942   AY089226 AAL89964   BF493871   BF496255   BG633819   BI215517   BI215799   BI371974   BI371992   BI372260   BI580490   BI638299   BI641230   BI641930   BI641937   BI641938   BT044244   CO177225   CZ481919   EC052581   EC053089   EC053964   EC054327   EC055101   EC055489   EC055512   EC055652   EC081035   EL883263   EL883264   GH748063   GH748275   GH748507   GH748855   GH749743   GH750256   GH751347   GH751486   GH753295   GH753845   GH756889   GH757263   GH757322   GH760993   GH771038   GH772891   GH774171   GH775333   GH778254   GH781633   GH784502   GH785002   GH785439   GH787094   GH789050   GH796451   GH797626   GH800522   GH803068   GH803859   GH804196   GH804604   GH805655   GH808506   GH810418   GH814181   GH815559   GH816012   GH820660   GH825276   GH826432   GH826550   GH826948   GH830315   GH830519   GH830746   GH837144   GH840117   GH841419   GH841968   GH842449   GH842944   GH846128   GH847177   GH848325   GH848673   GH850056   GH851741   GH853713   GH854614   GH855174   GH856090   GH857893   GH858462   GH858529   GH867089   GH867159   GH868030   GH869291   GH869645   GH871557   GH872072   GH872087   GH872651   GH872712   GH873417   GH873742   GH874268   GH875867   GH877079   GH878196   GH882623   GH886274   GH889373   GH890109   GH891144   GH891618   GH891870   GH892785   GH892825   GH892954   GH895801   GH896435   GH901298   GH904350   GH904864   GH908314   GH909871   GH912282   GH913234   GH914391   GH915792   GH917385   GH918316   GH919633   GH920457   GH922196   GH922380   GH924378   GH924828   GH925222   GH925575   GH927841   GH928514   GH931116   GH931220   GH931279   GH932826   GH935154   GH937958   GH938187   GH938897   GH939143   L39629   U60298 AAC47290   U62547 AAC47658
UniProtKB/Swiss-Prot	Q27607
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0004406    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0004406 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0004406 expression level Developmental Stage   Expression Level embryo 00-02hr    2472 embryo 02-04hr    2066 embryo 04-06hr    1311 embryo 06-08hr    1212 embryo 08-10hr    1133 embryo 10-12hr    597 embryo 12-14hr    412 embryo 14-16hr    550 embryo 16-18hr    351 embryo 18-20hr    238 embryo 20-22hr    212 embryo 22-24hr    227 larva L1    399 larva L2    418 larva L3 12hr old    378 larva L3 puffstage 1-2    182 larva L3 puffstage 3-6    235 larva L3 puffstage 7-9    239 white prepupae new    204 white prepupae 12hr    279 white prepupae 24hr    306 pupae 2d postWPP    242 pupae 3d postWPP    160 pupae 4d postWPP    210 adult male 01day    247 adult male 05day    320 adult male 30day    352 adult female 01day    905 adult female 05day    1335 adult female 30day    1423 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2472) embryo 02-04hr  (2066) embryo 04-06hr  (1311) embryo 06-08hr  (1212) embryo 08-10hr  (1133) embryo 10-12hr  (597) embryo 12-14hr  (412) embryo 14-16hr  (550) embryo 16-18hr  (351) embryo 18-20hr  (238) embryo 20-22hr  (212) embryo 22-24hr  (227) larva L1  (399) larva L2  (418) larva L3 12hr old  (378) larva L3 puffstage 1-2  (182) larva L3 puffstage 3-6  (235) larva L3 puffstage 7-9  (239) white prepupae new  (204) white prepupae 12hr  (279) white prepupae 24hr  (306) pupae 2d postWPP  (242) pupae 3d postWPP  (160) pupae 4d postWPP  (210) adult male 01day  (247) adult male 05day  (320) adult male 30day  (352) adult female 01day  (905) adult female 05day  (1335) adult female 30day  (1423) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2472) embryo 02-04hr  (2066) embryo 04-06hr    1311 embryo 06-08hr    1212 embryo 08-10hr    1133 embryo 10-12hr    597 embryo 12-14hr    412 embryo 14-16hr    550 embryo 16-18hr    351 embryo 18-20hr    238 embryo 20-22hr    212 embryo 22-24hr    227 larva L1    399 larva L2    418 larva L3 12hr old    378 larva L3 puffstage 1-2    182 larva L3 puffstage 3-6    235 larva L3 puffstage 7-9    239 white prepupae new    204 white prepupae 12hr    279 white prepupae 24hr    306 pupae 2d postWPP    242 pupae 3d postWPP    160 pupae 4d postWPP    210 adult male 01day    247 adult male 05day    320 adult male 30day    352 adult female 01day    905 adult female 05day    1335 adult female 30day  1423 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2472 embryo 02-04hr    2066 embryo 04-06hr    1311 embryo 06-08hr    1212 embryo 08-10hr    1133 embryo 10-12hr    597 embryo 12-14hr    412 embryo 14-16hr    550 embryo 16-18hr    351 embryo 18-20hr    238 embryo 20-22hr    212 embryo 22-24hr    227 larva L1    399 larva L2    418 larva L3 12hr old    378 larva L3 puffstage 1-2    182 larva L3 puffstage 3-6    235 larva L3 puffstage 7-9    239 white prepupae new    204 white prepupae 12hr    279 white prepupae 24hr    306 pupae 2d postWPP    242 pupae 3d postWPP    160 pupae 4d postWPP    210 adult male 01day    247 adult male 05day    320 adult male 30day    352 adult female 01day    905 adult female 05day    1335 adult female 30day    1423 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2472 embryo 02-04hr    2066 embryo 04-06hr    1311 embryo 06-08hr    1212 embryo 08-10hr    1133 embryo 10-12hr    597 embryo 12-14hr    412 embryo 14-16hr    550 embryo 16-18hr    351 embryo 18-20hr    238 embryo 20-22hr    212 embryo 22-24hr    227 larva L1    399 larva L2    418 larva L3 12hr old    378 larva L3 puffstage 1-2    182 larva L3 puffstage 3-6    235 larva L3 puffstage 7-9    239 white prepupae new    204 white prepupae 12hr    279 white prepupae 24hr    306 pupae 2d postWPP    242 pupae 3d postWPP    160 pupae 4d postWPP    210 adult male 01day    247 adult male 05day    320 adult male 30day    352 adult female 01day    905 adult female 05day    1335 adult female 30day    1423 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0004406 expression level Developmental Stage   Expression Level embryo 00-02hr    2472 embryo 02-04hr    2066 embryo 04-06hr    1311 embryo 06-08hr    1212 embryo 08-10hr    1133 embryo 10-12hr    597 embryo 12-14hr    412 embryo 14-16hr    550 embryo 16-18hr    351 embryo 18-20hr    238 embryo 20-22hr    212 embryo 22-24hr    227 larva L1    399 larva L2    418 larva L3 12hr old    378 larva L3 puffstage 1-2    182 larva L3 puffstage 3-6    235 larva L3 puffstage 7-9    239 white prepupae new    204 white prepupae 12hr    279 white prepupae 24hr    306 pupae 2d postWPP    242 pupae 3d postWPP    160 pupae 4d postWPP    210 adult male 01day    247 adult male 05day    320 adult male 30day    352 adult female 01day    905 adult female 05day    1335 adult female 30day    1423 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2472) embryo 02-04hr  (2066) embryo 04-06hr  (1311) embryo 06-08hr  (1212) embryo 08-10hr  (1133) embryo 10-12hr  (597) embryo 12-14hr  (412) embryo 14-16hr  (550) embryo 16-18hr  (351) embryo 18-20hr  (238) embryo 20-22hr  (212) embryo 22-24hr  (227) larva L1  (399) larva L2  (418) larva L3 12hr old  (378) larva L3 puffstage 1-2  (182) larva L3 puffstage 3-6  (235) larva L3 puffstage 7-9  (239) white prepupae new  (204) white prepupae 12hr  (279) white prepupae 24hr  (306) pupae 2d postWPP  (242) pupae 3d postWPP  (160) pupae 4d postWPP  (210) adult male 01day  (247) adult male 05day  (320) adult male 30day  (352) adult female 01day  (905) adult female 05day  (1335) adult female 30day  (1423) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2472) embryo 02-04hr  2066 embryo 04-06hr    1311 embryo 06-08hr    1212 embryo 08-10hr    1133 embryo 10-12hr    597 embryo 12-14hr    412 embryo 14-16hr    550 embryo 16-18hr    351 embryo 18-20hr    238 embryo 20-22hr    212 embryo 22-24hr    227 larva L1    399 larva L2    418 larva L3 12hr old    378 larva L3 puffstage 1-2    182 larva L3 puffstage 3-6    235 larva L3 puffstage 7-9    239 white prepupae new    204 white prepupae 12hr    279 white prepupae 24hr    306 pupae 2d postWPP    242 pupae 3d postWPP    160 pupae 4d postWPP    210 adult male 01day    247 adult male 05day    320 adult male 30day    352 adult female 01day    905 adult female 05day    1335 adult female 30day  1423 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2472 embryo 02-04hr    2066 embryo 04-06hr    1311 embryo 06-08hr    1212 embryo 08-10hr    1133 embryo 10-12hr    597 embryo 12-14hr    412 embryo 14-16hr    550 embryo 16-18hr    351 embryo 18-20hr    238 embryo 20-22hr    212 embryo 22-24hr    227 larva L1    399 larva L2    418 larva L3 12hr old    378 larva L3 puffstage 1-2    182 larva L3 puffstage 3-6    235 larva L3 puffstage 7-9    239 white prepupae new    204 white prepupae 12hr    279 white prepupae 24hr    306 pupae 2d postWPP    242 pupae 3d postWPP    160 pupae 4d postWPP    210 adult male 01day    247 adult male 05day    320 adult male 30day    352 adult female 01day    905 adult female 05day    1335 adult female 30day    1423 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2472 embryo 02-04hr    2066 embryo 04-06hr    1311 embryo 06-08hr    1212 embryo 08-10hr    1133 embryo 10-12hr    597 embryo 12-14hr    412 embryo 14-16hr    550 embryo 16-18hr    351 embryo 18-20hr    238 embryo 20-22hr    212 embryo 22-24hr    227 larva L1    399 larva L2    418 larva L3 12hr old    378 larva L3 puffstage 1-2    182 larva L3 puffstage 3-6    235 larva L3 puffstage 7-9    239 white prepupae new    204 white prepupae 12hr    279 white prepupae 24hr    306 pupae 2d postWPP    242 pupae 3d postWPP    160 pupae 4d postWPP    210 adult male 01day    247 adult male 05day    320 adult male 30day    352 adult female 01day    905 adult female 05day    1335 adult female 30day    1423 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0004406    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0004406 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0004406 expression level Tissue   Expression Level Larval Central Nervous System    40.975 Larval Midgut no informative data Larval Hindgut    35.2 Larval Malpighian Tubules    21.9 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    38.025 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    14.925 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    82.4 Adult Testis    40.5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    40.975 Larval Midgut no informative data Larval Hindgut    35.2 Larval Malpighian Tubules    21.9 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    38.025 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    14.925 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    82.4 Adult Testis    40.5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    40.975 Larval Midgut no informative data Larval Hindgut    35.2 Larval Malpighian Tubules    21.9 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    38.025 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    14.925 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    82.4 Adult Testis    40.5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    40.975 Larval Midgut no informative data Larval Hindgut    35.2 Larval Malpighian Tubules    21.9 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    38.025 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    14.925 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    82.4 Adult Testis    40.5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0004406 expression level Tissue   Expression Level Larval Central Nervous System    40.975 Larval Midgut no informative data Larval Hindgut    35.2 Larval Malpighian Tubules    21.9 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    38.025 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    14.925 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    82.4 Adult Testis    40.5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    40.975 Larval Midgut no informative data Larval Hindgut    35.2 Larval Malpighian Tubules    21.9 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    38.025 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    14.925 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    82.4 Adult Testis    40.5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    40.975 Larval Midgut no informative data Larval Hindgut    35.2 Larval Malpighian Tubules    21.9 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    38.025 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    14.925 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    82.4 Adult Testis    40.5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    40.975 Larval Midgut no informative data Larval Hindgut    35.2 Larval Malpighian Tubules    21.9 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    38.025 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    14.925 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    82.4 Adult Testis    40.5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea     Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    no informative data   NA  Brain    no informative data   40.975  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    no informative data   no informative data  Midgut    no informative data   35.2  Hindgut    no informative data   21.9  Malpighian Tubules    no informative data   no informative data  Fat Body    no informative data   no informative data  Salivary Gland    no informative data   NA  Heart    14.925   38.025  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    82.4   NA  Testis    40.5   NA  Male Accessory Gland    no informative data   no informative data  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_13
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004406 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8987-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | larval stage | recessive tam2 tam3 tam4 tam9 lethal | recessive tam2 tam3 tam4 viable, with Scer\GAL4pnr-MD237 tamGD1549 viable | poor tam10 Other Phenotypes Allele locomotor behavior defective | larval stage tamunspecified locomotor behavior defective | larval stage | recessive tam3 tam9 neuroanatomy defective (with tam2) tam9 neuroanatomy defective (with tam9) tam2 visible | recessive tam10 Phenotype manifest in Allele adult cuticle tamγ125.hs adult cuticle, with Scer\GAL4hs.PB tamγ125.Scer\UAS adult thorax & macrochaeta tam10 eye tam10 eye, with Scer\GAL4hs.PB tamγ125.Scer\UAS eye disc tam3 tam9 head bristle tam10 tamunspecified leg tamγ125.hs leg, with Scer\GAL4hs.PB tamγ125.Scer\UAS macrochaeta tamγ125.hs macrochaeta, with Scer\GAL4444 tamγ125.Scer\UAS macrochaeta, with Scer\GAL4hs.PB tamγ125.Scer\UAS mesothoracic tergum, with Scer\GAL4hs.PB tamγ125.Scer\UAS mitochondrion (with tam2) tam9 mitochondrion (with tam9) tam2 photoreceptor cell tam3 tam9 photoreceptor cell & axon tam3 tam9 pupal cuticle, with Scer\GAL4444 tamγ125.Scer\UAS scutum & macrochaeta tamunspecified wing tamunspecified wing, with Scer\GAL4hs.PB tamγ125.Scer\UAS wing margin bristle, with Scer\GAL4hs.PB tamγ125.Scer\UAS wing vein tamunspecified
Classical Alleles ( 15 )
For All Classical Alleles Show
Allele of tam Class Mutagen Stocks Known lesion tam3 ethyl methanesulfonate 3 Yes tam4 ethyl methanesulfonate 1 Yes tamC021 1 -- tamf04330 1 -- tam10 hypomorphic allele - genetic evidence 0 -- tam1 ethyl methanesulfonate 0 -- tam2 ethyl methanesulfonate 0 Yes tam5 ethyl methanesulfonate 0 -- tam6 ethyl methanesulfonate 0 -- tam7 ethyl methanesulfonate 0 -- tam8 ethyl methanesulfonate 0 -- tam9 ethyl methanesulfonate 0 Yes tame04160 piggyBac transposase 0 -- tamf07705 0 -- tamunspecified 0 --
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of tam Class Mutagen Stocks Known lesion tamGD1549 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes tamJF01532 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes tamJF01563 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes tamKK100485 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes tamγ125.hs in vitro construct - regulatory fusion 0 Yes tamγ125.MtnA in vitro construct - regulatory fusion 0 Yes tamγ125.Scer\UAS in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)64j (Iyengar et al., 1999, Woodruff and Ashburner, 1979) Df(2L)b75 (Woodruff and Ashburner, 1979, Gubb et al., 1990) Df(2L)b80c1 (Iyengar et al., 1999, Iyengar et al., 2002) Df(2L)b82a3 (Roote, 2000.7.3, Roote, 1995.3.27, Roote, 1997.6.3) Df(2L)b84a4 (Bonfini et al., 1992) Df(2L)b84a9 (Iyengar et al., 1999) Df(2L)b85b2 (Iyengar et al., 1999, Roote, 2000.7.3, Roote, 1995.3.27, Alexandrova et al., 1996, Roote, 1997.6.3) Df(2L)b85c1 (Alexandrova et al., 1996) Df(2L)b88b42 (Iyengar et al., 1999, Roote, 2000.7.3, Roote, 1995.3.27, Roote, 1997.6.3) Df(2L)BSC252 (Christensen and Cook, 2007.3.22) Df(2L)Exel7059 (Ryder, 2004.4.26) Df(2L)fn30 (Ashburner et al., 1982) Df(2L)fn31 (Ashburner et al., 1982) Df(2L)GT5 (Gubb et al., 1990) Df(2L)Sco7 (Roote, 1996.8) Df(2L)TE35B-5 (Gubb et al., 1985) Df(2L)TE35BC-6 (Gubb et al., 1984) Df(2L)TE35BC-23 (Gubb et al., 1984) In(2L)b79h1A (Iyengar et al., 1999, Roote, 1995.3.27, Roote, 1997.6.3) In(2L)b79d5 (Roote, 1997.6.3) In(2L)b83b22 (Iyengar et al., 1999, Roote, 1997.6.3) In(2LR)b81a2 (Iyengar et al., 1999, Bonfini et al., 1992, Roote, 1995.3.27, Roote, 1997.6.3) In(2LR)b81a2LDTD43R (Bonfini et al., 1992) T(2;3)b89e12 (Roote, 1998.5.15)
Not disrupted in	Df(2L)A47 (Ashburner et al., 1982, Gubb et al., 1990) Df(2L)A48 (Ashburner et al., 1982, Gubb et al., 1990) Df(2L)A63 (Ashburner et al., 1982) Df(2L)A72 (Ashburner et al., 1982) Df(2L)A178 (Ashburner et al., 1982) Df(2L)A215 (Ashburner et al., 1982) Df(2L)A217 (Ashburner et al., 1982) Df(2L)A220 (Ashburner et al., 1982) Df(2L)A245 (Ashburner et al., 1982) Df(2L)A246 (Ashburner et al., 1982) Df(2L)A260 (Ashburner et al., 1982) Df(2L)A263 (Ashburner et al., 1982) Df(2L)A264 (Ashburner et al., 1982) Df(2L)A266 (Ashburner et al., 1982) Df(2L)A267 (Ashburner et al., 1982) Df(2L)A376 (Ashburner et al., 1982) Df(2L)A377 (Ashburner et al., 1982) Df(2L)A379 (Ashburner et al., 1982) Df(2L)A400 (Ashburner et al., 1982) Df(2L)A445 (Ashburner et al., 1982) Df(2L)b89e80b (Roote, 2000.7.3) Df(2L)el77 (Woodruff and Ashburner, 1979) Df(2L)fn1 (Woodruff and Ashburner, 1979, Ashburner et al., 1982) Df(2L)fn2 (Woodruff and Ashburner, 1979, Ashburner et al., 1982) Df(2L)fn3 (Woodruff and Ashburner, 1979, Ashburner et al., 1982) Df(2L)fn5 (Ashburner et al., 1982) Df(2L)fn7 (Woodruff and Ashburner, 1979, Ashburner et al., 1982) Df(2L)fn12 (Woodruff and Ashburner, 1979, Ashburner et al., 1982) Df(2L)fn15 (Ashburner et al., 1982) Df(2L)fn26 (Ashburner et al., 1982) Df(2L)fn27 (Ashburner et al., 1982) Df(2L)fn36 (Ashburner et al., 1982) Df(2L)GT4 (Gubb et al., 1990) Df(2L)Scorv4 (Woodruff and Ashburner, 1979) Df(2L)TE35B-1 (Gubb et al., 1985) Df(2L)TE35B-2 (Gubb et al., 1985) Df(2L)TE35B-3 (Gubb et al., 1985) Df(2L)TE35B-4 (Gubb et al., 1985) Df(2L)TE35B-6 (Gubb et al., 1985) Df(2L)TE35B-7 (Gubb et al., 1985) Df(2L)TE35B-8 (Gubb et al., 1985) Df(2L)TE35B-9 (Gubb et al., 1985) Df(2L)TE35B-10 (Gubb et al., 1985) Df(2L)TE35B-11 (Gubb et al., 1985) Df(2L)TE35B-12 (Gubb et al., 1985) Df(2L)TE35B-15 (Gubb et al., 1985) Df(2L)TE35BC-1 (Gubb et al., 1984) Df(2L)TE35BC-3 (Gubb et al., 1984) Df(2L)TE35BC-4 (Gubb et al., 1984) Df(2L)TE35BC-7 (Gubb et al., 1984) Df(2L)TE35BC-8 (Gubb et al., 1984) Df(2L)TE35BC-24 (Gubb et al., 1984) Df(2L)TE35BC-28 (Gubb et al., 1984) Df(2L)TE35BC-29 (Gubb et al., 1984) Df(2L)TE35BC-31 (Gubb et al., 1984) Df(2L)TE35BC-34 (Gubb et al., 1984) Df(2L)TE35BC-35 (Gubb et al., 1984) Df(2L)W (Woodruff and Ashburner, 1979) In(2L)75c (Woodruff and Ashburner, 1979) In(2L)75cLC158.1R (Woodruff and Ashburner, 1979) In(2L)b81l7 (Iyengar et al., 1999) In(2L)b82c44 (Iyengar et al., 1999) In(2L)TE35B-13 (Gubb et al., 1985) In(2LR)b71k1A (Roote, 1997.2.3) T(2;3)Scorv7 (Woodruff and Ashburner, 1979) T(Y;2)A80DR15P (Woodruff and Ashburner, 1979) T(Y;2)J165DP58P (Woodruff and Ashburner, 1979) T(Y;2)R15DJ165P (Woodruff and Ashburner, 1979) Tp(2;2)A446 (Ashburner et al., 1982)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data heat-shock construct P{hs-γ125} NA UAS construct P{GD1549} NA P{KK100485} NA P{TRiP.JF01532} NA P{TRiP.JF01563} NA P{UAS-γ125} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{3HPy+}tamC021 NA PBac{RB}tame04160 NA PBac{WH}tamf04330 NA PBac{WH}tamf07705 NA
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function
CV term Evidence References
DNA-directed DNA polymerase activity inferred from direct assay (Wernette and Kaguni, 1986)
Biological Process
CV term Evidence References
DNA-dependent DNA replication inferred from direct assay (Wernette and Kaguni, 1986)
Cellular Component
CV term Evidence References
gamma DNA polymerase complex inferred from direct assay (Wernette and Kaguni, 1986)
Terms Based on Predictions or Assertions ( 9 terms )
Molecular Function
CV term Evidence References
3'-5'-exodeoxyribonuclease activity non-traceable author statement (Swiss-Prot Project Members, 1997.2.1) DNA binding inferred from electronic annotation with InterPro:IPR001098, InterPro:IPR002297 (FlyBase Curators et al., 2004-) DNA-directed DNA polymerase activity inferred from sequence or structural similarity (Ashburner et al., 1999) inferred from sequence or structural similarity with UniProtKB:P54098 (Sardiello et al., 2003.6.11) non-traceable author statement (Burgers et al., 2001)
Biological Process
CV term Evidence References
determination of adult lifespan non-traceable author statement (Mandavilli et al., 2002) DNA-dependent DNA replication inferred from sequence or structural similarity with UniProtKB:P54098 (Sardiello et al., 2003.6.11) non-traceable author statement (Burgers et al., 2001, Swiss-Prot Project Members, 1997.2.1) eclosion non-traceable author statement (Mandavilli et al., 2002) mitochondrial DNA replication traceable author statement (Garesse and Vallejo, 2001)
Cellular Component
CV term Evidence References
gamma DNA polymerase complex inferred from sequence or structural similarity (Ashburner et al., 1999) mitochondrion inferred from sequence or structural similarity with UniProtKB:P54098 (Sardiello et al., 2003.6.11) non-traceable author statement (Burgers et al., 2001, Swiss-Prot Project Members, 1997.2.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions tam allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60825 DroID - A comprehensive database of gene and protein interactions. • FBgn0004406 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34792
Orthologs
Genome-wide drosophilid orthologs	Dana\GF15619 Dere\GG10182 Dgri\GH10618 Dmoj\GI19730 Dper\GL21087 Dpse\GA21456 Dsec\GM15104 Dsim\GD22040 Dvir\GJ18089 Dwil\GK24652 Dyak\GE11427
Curated drosophilid orthologs	Dpse\GA21456
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL015671-PA Aedes aegypti (mosquito) AGAP000139-PA Anopheles gambiae (mosquito) XP_395230.3 Apis mellifera (honey bee) XP_001950479.1 Acyrthosiphon pisum (pea aphid) 14887 Batrachochytrium dendrobatidis (chytrid fungus) 124349 Branchiostoma floridae (lancelet) BGIBMGA009359-PA Bombyx mori (silk worm) ENSBTAP00000011993 Bos taurus (bovine) CAL0004952 Candida albicans (a form of yeast) CBP25952 Caenorhabditis briggsae (nematode) CE25501 Caenorhabditis elegans (worm) ENSCAFP00000017511 Canis familiaris (dog) CAGL0E05324g Candida glabrata (haploid yeast) ENSCINP00000002612 Ciona intestinalis (sea squirt) JA00803 Caenorhabditis japonica (nematode) CPIJ012266 Culex pipens (mosquito) ENSCPOP00000006546 Cavia porcellus (guinea pig) RP40110 Caenorhabditis remanei (nematode) ENSCSAVP00000009550 Ciona savignyi (sedentary tunicate) 18002 Capitella spl (polychaete worm) DEHA2F12628g Debaryomyces Hansenii (yeast) 226991 Daphnia pulex (daphnia) ENSDARP00000080832 Danio rerio (zebra fish) ENSECAP00000006347 Equus caballus (horse) ENSGACP00000015323 Gymnopilus aculeatus (mushroom) ENSGALP00000037807 Gallus gallus (chicken) ENSP00000268124 Homo sapiens (human) ISCW023232-PA Ixodes scapularis (deer tick) 239325 Lottia gigantea (owl limpet) 624 Monocosta brevicollis (choanoflagellate) ENSMODP00000024410 Monodelphis domestica (gray opossum) ENSMMUP00000014614 Macaca mulatta (rhesus monkey) ENSMUSP00000035345 Mus musculus (house mouse) 10127 Nematostella vectensis (starlet anemone) XP_001602202.1 Nasonia vitripennis (wasp) ENSORLP00000014662 Oryzias latipes (japanese killifish) PHUM000405-PA Pediculus humanus (human body louse) ENSPPYP00000007673 Pongo pygmaeus (orangutan) ENSPTRP00000012706 Pan troglodytes (chimpanzee) ENSRNOP00000047900 Rattus norvegicus (norway rat) YOR330C Saccharomyces cerevisiae (budding yeast) Smp_161380 Schistosoma mansoni (trematode parasite) SPCC24B10.22 Schizosaccharomyces pombe (fission yeast) 64268 Trichoplax adhaerens (metazoa) XP_968888.2 Tribolium castaneum (red flour beetle) ENSTNIP00000015124 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000000907 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000038527 Xenopus tropicalis (frog) YALI0F19404g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12973 NV18944 LH14949 ISCW023232 FBgn0229233 FBgn0226612 FBgn0205254 FBgn0193453 FBgn0170024 JGI_V11_226991 FBgn0081443 FBgn0158682 FBgn0142467 FBgn0118099 FBgn0102492 FBgn0092643 CPIJ012266 BGIBMGA009359 ACYPI004049 GB10422 AGAP000139 AAEL015671 PHUM216960 GLEAN_08519
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	3410 tam3 b1 Adhn4/CyO 31081 y1 v1; P{TRiP.JF01532}attP2 31098 y1 v1; P{TRiP.JF01563}attP2 16257 y1 w1118; PBac{3HPy+}tamC021/CyO 25145 b1 tam4 Adhn2 pr1 cn1/CyO
Harvard	- PBac{WH}tamf04330
Kyoto	107034 tam3 b1 Adhn4/CyO 101317 b1 tam3 Adhn4 / CyO, Cy1 dplv1 pr1 cn2
VDRC	v106955 P{KK100485}VIE-260B v3133 w1118; P{GD1549}v3133 v3135 w1118; P{GD1549}v3135
Genomic Clones ( 2 )
	BACR16P12 BACR30I21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 157 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT02241
Other clones	FI06005
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT10016 AT29751 LD02053 LD06421 LD18609 LD39396 RE22039 RE22513 RE55766 RE56166 RE59179 RE74687 SD01711 SD03438 SD05822 SD07913 SD20552 SD24449 SD25608 SD25618 SD25619
Other clones	CK01.65A.E11 EC052581 EC053089 EC053964 EC054327 EC055101 EC055489 EC055512 EC055652 EK052920 IP12957 RP003016100 RP003020533 RP003022106 RP003023084 RP003026398 RP003029348 RP003042712 RP003047244 RP003047459 RP003055973 RP003057112 RP003058048 RP003069984 RP003075863 RP003082740 RP003082819 RP003083107 RP003084326 RP003091275 RP003104524 RP003109373 RP003112052 RP003118502 RP003122403 RP003124725 RP003125081 RP003138312 RP003143868 RP003157086 RP003160696 RP003163866 RP003164186 RP003167132 RP003180113 RP003190622 RP003213601 RP003223251 RP003223562 RP003228106 RP003228312 RP003235273 RP003237781 RP003240299 RP003249097 RP003257547 RP003260017 RP003260963 RP003261467 RP003265487 RP003266618 RP003268038 RP003276193 RP003288992 RP003290771 RP003293538 RP003296527 RP003296734 RP003300358 RP003303020 RP003303677 RP003304228 RP003305172 RP003310251 RP003318995 RP003319090 RP003320074 RP003323022 RP003325969 RP003343750 RP003346368 RP003358944 RP003361462 RP003362445 RP003364071 RP003365373 RP003365510 RP003370548 RP003375066 RP003376126 RP003385720 RP003399811 RP003418680 RP003423598 RP003438051 RP003446620 RP003463772 RP003465879 RP003468183 RP003471322 RP003472173 RP003477636 RP003487978 RP003509342 RP003516474 RP003540657 RP003545140 RP003554230 RP003555487 RP003559792 RP003561886 RP003569376 RP003571290 RP003573061 RP003575668 RP003580320 RP003580412 RP003585134 RP003585531 RP003593530 RP003595039 RP003606283 RP003608219 RP003608522 RP003613426 RP003622995 RP003626874 RP003640083 RP003654107 RP003654878 RP003655140 RP003661371 RP003677808 RP003679543
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004406 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34792
Antibody Information
Other Information
Discoverer
Etymology
	The gene is named "tamas" (Sanskrit meaning "dark inertia") based on the mutant phenotype of a reduction in the larval response to light. (Iyengar et al., 1999)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: tam CG8987 (Guan, 1999.11)
Source for database merge of	Source for merge of: tamas anon-34Dc (Ashburner et al., 1999.10.12) Source for merge of: tamas l(2)34Dc (Ashburner et al., 1999)
Additional comments
Other Comments
	Multiple amino acid sequence alignments show the DNA polymerases from numerous species forms a family strongly conserved from yeast to man. (Lecrenier et al., 1997) Cloning and biochemical characterisation of tam demonstrates both 5' to 3' DNA polymerase activity and 3' to 5' exonuclease activity in the recombinant protein. tam polypeptide amino acid sequence is 1145 residues, with a predicted molecular mass of 129.9kD. (Lewis et al., 1996) Cloning, sequencing and characterisation of tam. (Ropp and Copeland, 1996) Subunit structure and enzymatic activity of DNA polymerase γ are studied using a combination of physical and immunological approaches. The role of the 2 subunits in template primer DNA binding is explored. (Olson et al., 1995) mtSSB stimulates DNA polymerase γ activity in vitro. (Williams and Kaguni, 1995) The rate and processivity of DNA synthesis by DNA polymerase γ has been analysed under a variety of different conditions. (Williams et al., 1993) Transcript identified during molecular analysis of the Sos genomic region. (Bonfini et al., 1992) Biochemical description of the 3'->5' exonuclease associated with mitochondrial DNA polymerase. (Olson and Kaguni, 1992) The 3' to 5' exonuclease encoded provides a proof-reading function to enhance the fidelity of DNA synthesis during mitochondrial DNA replication. (Kaguni and Olson, 1989) A structural and mechanistic analysis of DNApol-γ125 and DNApol-γ35 demonstrates them to be both effective and accurate in the synthesis of DNA. (Kaguni et al., 1988) Comparison of the rate and specificity of DNA synthesis by DNApol-γ125 and DNApol-γ35 on several template primers, and an examination of the products of DNA synthesis has been carried out. (Wernette et al., 1988) DNApol-γ125 and DNApol-γ35 have been isolated and purified and their subunit structure and catalytic properties examined. (Wernette and Kaguni, 1986)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057473 RefSeq (Proteins) • NP_476821 DDBJ / EMBL / GenBank • AA263336 AA538934 AA816552 AAC47290 AAC47658 AAF44822 AAF53338 AAL89964 AC092223 AE003408 AY089226 BF493871 CZ481919 L39629 U60298 U62547 Entrez Gene - A searchable database of RefSeq genes. • 34792 UniProtKB/Swiss-Prot • Q27607
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • DNA-directed DNA polymerase, family A, palm domain (IPR001098) DNA-directed DNA-polymerase, family A, mitochondria (IPR002297) DNA-directed DNA polymerase, family A, conserved site (IPR019760) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME08987
Linkouts
	BioGRID - A database of protein and genetic interactions • 60825 DroID - A comprehensive database of gene and protein interactions. • FBgn0004406 DRSC - Results from RNAi screens. • FBgn0004406 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004406 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8987-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004406 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34792 InParanoid A subset of ortholog calls from InParanoid. • AAEL015671-PA Aedes aegypti (mosquito) AGAP000139-PA Anopheles gambiae (mosquito) XP_395230.3 Apis mellifera (honey bee) XP_001950479.1 Acyrthosiphon pisum (pea aphid) 14887 Batrachochytrium dendrobatidis (chytrid fungus) 124349 Branchiostoma floridae (lancelet) BGIBMGA009359-PA Bombyx mori (silk worm) ENSBTAP00000011993 Bos taurus (bovine) CAL0004952 Candida albicans (a form of yeast) CBP25952 Caenorhabditis briggsae (nematode) CE25501 Caenorhabditis elegans (worm) ENSCAFP00000017511 Canis familiaris (dog) CAGL0E05324g Candida glabrata (haploid yeast) ENSCINP00000002612 Ciona intestinalis (sea squirt) JA00803 Caenorhabditis japonica (nematode) CPIJ012266 Culex pipens (mosquito) ENSCPOP00000006546 Cavia porcellus (guinea pig) RP40110 Caenorhabditis remanei (nematode) ENSCSAVP00000009550 Ciona savignyi (sedentary tunicate) 18002 Capitella spl (polychaete worm) DEHA2F12628g Debaryomyces Hansenii (yeast) 226991 Daphnia pulex (daphnia) ENSDARP00000080832 Danio rerio (zebra fish) ENSECAP00000006347 Equus caballus (horse) ENSGACP00000015323 Gymnopilus aculeatus (mushroom) ENSGALP00000037807 Gallus gallus (chicken) ENSP00000268124 Homo sapiens (human) ISCW023232-PA Ixodes scapularis (deer tick) 239325 Lottia gigantea (owl limpet) 624 Monocosta brevicollis (choanoflagellate) ENSMODP00000024410 Monodelphis domestica (gray opossum) ENSMMUP00000014614 Macaca mulatta (rhesus monkey) ENSMUSP00000035345 Mus musculus (house mouse) 10127 Nematostella vectensis (starlet anemone) XP_001602202.1 Nasonia vitripennis (wasp) ENSORLP00000014662 Oryzias latipes (japanese killifish) PHUM000405-PA Pediculus humanus (human body louse) ENSPPYP00000007673 Pongo pygmaeus (orangutan) ENSPTRP00000012706 Pan troglodytes (chimpanzee) ENSRNOP00000047900 Rattus norvegicus (norway rat) YOR330C Saccharomyces cerevisiae (budding yeast) Smp_161380 Schistosoma mansoni (trematode parasite) SPCC24B10.22 Schizosaccharomyces pombe (fission yeast) 64268 Trichoplax adhaerens (metazoa) XP_968888.2 Tribolium castaneum (red flour beetle) ENSTNIP00000015124 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000000907 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000038527 Xenopus tropicalis (frog) YALI0F19404g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34792 modMine - Data generated by the modENCODE project. • FBgn0004406 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12973 NV18944 LH14949 ISCW023232 FBgn0229233 FBgn0226612 FBgn0205254 FBgn0193453 FBgn0170024 JGI_V11_226991 FBgn0081443 FBgn0158682 FBgn0142467 FBgn0118099 FBgn0102492 FBgn0092643 CPIJ012266 BGIBMGA009359 ACYPI004049 GB10422 AGAP000139 AAEL015671 PHUM216960 GLEAN_08519
Synonyms & Secondary IDs ( 37 )
Reported As
Symbol Synonym	34Dc (Bonfini et al., 1992) AAC47658 (Burgers et al., 2001) anon-34Dc (Ashburner et al., 1999.10.12, ) BG:DS00941.6 (Ashburner et al., 1999.10.12, Ashburner et al., 1999) br5 (Gubb et al., 1985) cDNA 2 (Bonfini et al., 1992) CG8987 (Keleman et al., 2009.8.5, Chen et al., 2008, Ni et al., 2008) DNApol-γ (Dusenbery and Smith, 1996, Williams and Kaguni, 1995, Williams et al., 1993) DNApol-γ125 (Ropp and Copeland, 1996, Lewis et al., 1996, Olson et al., 1995, Kaguni et al., 1988, Olson and Kaguni, 1992, Kaguni and Olson, 1989, Wernette et al., 1988, Wernette and Kaguni, 1986, ) D-pol γ-α (Lefai et al., 2000) l(2)34Dc (Pflumm and Botchan, 2001, Ashburner et al., 1999.10.12, Ashburner et al., 1999, Adachi-Yamada et al., 1999, Roote, 1998.5.15, Spradling et al., 1995, Gubb et al., 1990, ) l(2)br5 (Gubb et al., 1984, Ashburner et al., 1982, Woodruff and Ashburner, 1979, ) l(2)br14 (Woodruff and Ashburner, 1979) l(2)brS (The Moscow Regional Drosophila melanogaster Stock Center, Dubna) mtDNA pol (Pflumm and Botchan, 2001) MtPolA (Kaguni, 1996.6.27) mtPolA (Lefai et al., 2000) polγ (Farr et al., 1999) Polγ (Lecrenier et al., 1997) pol γ (Oliveira and Kaguni, 2008) pol γ-α (Luo and Kaguni, 2005, Matsushima et al., 2004, Fan and Kaguni, 2001, Lefai et al., 2000, Lefai et al., 2000, Matsushima et al., 2010) polγ-α (Lefai et al., 2000) tam (Christensen and Cook, 2007.3.22, De Lucia et al., 2005, Baqri et al., 2009, Chen et al., 2008, Scantlebury et al., 2007) Tam (Spresser et al., 2008) unnamed (Fernandez-Moreno et al., 2004)
Name Synonym	catalytic(α)subunit (Wang and Kaguni, 1999) catalytic subunit of the mitochondrial DNA polymerase (Sanchez-Martinez et al., 2006) DNA polymerase gamma (Ropp, 1996.6.9) DNA polymerase γ (Farr et al., 2004, Vontom and Kaguni, 1992) DNA polymerase γ 125kD   lethal 5 in the black-reduced region (Woodruff and Ashburner, 1979) lethal 14 in the black-reduced region (Woodruff and Ashburner, 1979) lethal(2)34Dc   mitochondrial γ polymerase (Mandavilli et al., 2002) mtDNA polymerase α (Hochheimer et al., 2002) tamas (Ashburner et al., 1999, Ashburner et al., 1999, Lefai et al., 2000, Chen et al., 2008, Scantlebury et al., 2007) α subunit (Alahari et al., 1999)
Secondary FlyBase IDs
	FBgn0000476 FBgn0001960 FBgn0020604
References ( 86 )
Generate a list of	All references relating to this gene ( 86 )
List References by type	Research paper  ( 40 ) Supplementary material  ( 4 ) Review  ( 6 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 16 ) Abstract  ( 6 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 2 ) Stock list  ( 1 ) Curated genome annotation  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Book  ( 1 )
Recent research papers ( 1 )
	Matsushima et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(43): 18410--18415 Mitochondrial Lon protease regulates mitochondrial DNA copy number and transcription by selective degradation of mitochondrial transcription factor A (TFAM). [FBrf0212193] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...