Gene model reviewed during 5.46
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\LysD using the Feature Mapper tool.
LysD transcripts are detected in the feeding stages (larvae and adults) with maximal expression in third instar larvae.
LysD transcripts are expressed at all feeding stages of development. Expression peaks in third instar larvae, declines then ceases in pupae and resumes in adults. Transcript levels are reduced after injection of bacteria. Strong epression is detected in the anterior region of the midgut by in situ hybridization in larvae and adults. In larvae, the anterior border of expressing tissue separates the proventriculus from the stomach. In adults, LysD expression starts at a point just caudal to the cardia. In both cases, strong staining is seen along the thoracic part of the midgut up to a discrete point in the abdomen where it abruptly ceases.
GBrowse - Visual display of RNA-Seq signalsView Dmel\LysD in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Lysozymes are expressed at a high level mainly in the digestive tract, they are not a component of the haemolymph. Lysozyme is not induced by bacteria so is not part of the inducible immune response but instead has been recruited for digestion of symbiotic bacteria in the stomach.
LysD has been cloned, sequenced and its developmental expression pattern analysed. The transcription levels of LysD decrease after bacterial injections into the haemocoel. The LysD gene product is therefore not induced as part of the immune response, but instead appears to have a role in the digestion of bacteria present in fermenting food.