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Gene Dmel\LysE

General Information
Symbol	Dmel\LysE	Species	D. melanogaster
Name	Lysozyme E	Annotation symbol	CG1180
Feature type	protein_coding_gene	FlyBase ID	FBgn0004428
Gene Model Status	Current	Stock availability	None publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	61F3-61F3	Sequence location	3L:1,212,827..1,213,406 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Lysozyme E is referred to in FlyBase by the symbol Dmel\LysE (CG1180, FBgn0004428). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: lysozyme activity. It is reported to be involved in the biological process: antimicrobial humoral response. One allele is reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Glycoside hydrolase, family 22; Glycoside hydrolase, family 22, conserved site; Glycoside hydrolase, family 22, lysozyme; Lysozyme-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of extremely low expression. Peak expression observed during early larval stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: No FlyAtlas data available because no Affy2 ProbeSet aligns to an exon of LysE. Comments on Affy2 ProbeSet: No relevant information because no Affy2 ProbeSet aligns to an exon of LysE. Gene sequence location is 3L:1212827..1213406.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 61F3-61F3   Limits computationally determined from genome sequence between P{PZ}l(3)0596705967 and P{PZ}l(3)0264002640
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\LysE for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46 DGC clone LP07339 appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) LysE-RA FBtr0072630  NM_057479   580   140
Additional Transcript Data & Comments
Reported size (kB)	0.486 (longest cDNA) (Daffre et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein LysE-PA   FBpp0072526   15.6   140   6.72     NP_476827   AAF47451
Additional Polypeptide Data & Comments
Reported size (kDa)	140 (aa) (Daffre et al., 1994)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Glycoside hydrolase, family 22, lysozyme (IPR000974) Glycoside hydrolase, family 22 (IPR001916) Glycoside hydrolase, family 22, conserved site (IPR019799) Lysozyme-like domain (IPR023346)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF47451   AC004489   AC005847   AI294047   AY119049   AY119059 AAM50919   AY232197   BT032778   BT032975   BT099968   BT120374   CO180998   CO194958   Z22227 CAA80229
UniProtKB/Swiss-Prot	P37159
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference larval stage   embryonic/larval midgut   (Daffre et al., 1994) RNase protection, primer extension, SI map Stage Tissue/Position (including subcellular localization) Reference larval stage & adult stage     (Daffre et al., 1994) adult stage   adult midgut   (Daffre et al., 1994)
Additional Descriptive Data
	LysE transcripts are detected in the feeding stages (larvae and adults) with maximal expression in third instar larvae. This expression pattern was surmised from RNase protection experiments with a probe from the closely related LysD gene. (Daffre et al., 1994)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    152 central nervous system, larvae L3    2 central nervous system, pupae P8    0 head, virgin 1-day female    5 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    6 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    79 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    2706 digestive system, 1-day adult    3271 digestive system, 4-day adult    1433 digestive system, 20-day adult    1375 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    22 carcass, larvae L3 wandering    11 carcass, 1-day adult    79 carcass, 4-day adult    46 carcass, 20-day adult    107 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    17 accessory gland, mated 4-day male    194 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (152) central nervous system, larvae L3    2 central nervous system, pupae P8    0 head, virgin 1-day female    5 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    6 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering  (79) salivary gland, white prepupae    1 digestive system, larvae L3 wandering  (2706) digestive system, 1-day adult  (3271) digestive system, 4-day adult  (1433) digestive system, 20-day adult  (1375) fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    22 carcass, larvae L3 wandering    11 carcass, 1-day adult  (79) carcass, 4-day adult  (46) carcass, 20-day adult  (107) ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    17 accessory gland, mated 4-day male  (194) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (152) central nervous system, larvae L3    2 central nervous system, pupae P8    0 head, virgin 1-day female    5 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    6 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    79 salivary gland, white prepupae    1 digestive system, larvae L3 wandering  (2706) digestive system, 1-day adult  (3271) digestive system, 4-day adult  (1433) digestive system, 20-day adult  (1375) fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    22 carcass, larvae L3 wandering    11 carcass, 1-day adult    79 carcass, 4-day adult    46 carcass, 20-day adult  107 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    17 accessory gland, mated 4-day male  (194) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    152 central nervous system, larvae L3    2 central nervous system, pupae P8    0 head, virgin 1-day female    5 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    6 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    79 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    2706 digestive system, 1-day adult    3271 digestive system, 4-day adult    1433 digestive system, 20-day adult    1375 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    22 carcass, larvae L3 wandering    11 carcass, 1-day adult    79 carcass, 4-day adult    46 carcass, 20-day adult    107 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    17 accessory gland, mated 4-day male    194 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    152 central nervous system, larvae L3    2 central nervous system, pupae P8    0 head, virgin 1-day female    5 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    6 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    79 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    2706 digestive system, 1-day adult    3271 digestive system, 4-day adult    1433 digestive system, 20-day adult    1375 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    22 carcass, larvae L3 wandering    11 carcass, 1-day adult    79 carcass, 4-day adult    46 carcass, 20-day adult    107 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    17 accessory gland, mated 4-day male    194 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (152) central nervous system, larvae L3    2 central nervous system, pupae P8    0 head, virgin 1-day female    5 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    6 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering  (79) salivary gland, white prepupae    1 digestive system, larvae L3 wandering  (2706) digestive system, 1-day adult  (3271) digestive system, 4-day adult  (1433) digestive system, 20-day adult  (1375) fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    22 carcass, larvae L3 wandering    11 carcass, 1-day adult  (79) carcass, 4-day adult  (46) carcass, 20-day adult  (107) ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    17 accessory gland, mated 4-day male  (194) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (152) central nervous system, larvae L3    2 central nervous system, pupae P8    0 head, virgin 1-day female    5 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    6 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    79 salivary gland, white prepupae    1 digestive system, larvae L3 wandering  (2706) digestive system, 1-day adult  (3271) digestive system, 4-day adult  (1433) digestive system, 20-day adult  (1375) fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    22 carcass, larvae L3 wandering    11 carcass, 1-day adult    79 carcass, 4-day adult    46 carcass, 20-day adult  107 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    17 accessory gland, mated 4-day male  (194) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    152 central nervous system, larvae L3    2 central nervous system, pupae P8    0 head, virgin 1-day female    5 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    6 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    79 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    2706 digestive system, 1-day adult    3271 digestive system, 4-day adult    1433 digestive system, 20-day adult    1375 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    22 carcass, larvae L3 wandering    11 carcass, 1-day adult    79 carcass, 4-day adult    46 carcass, 20-day adult    107 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    17 accessory gland, mated 4-day male    194 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of extremely low expression. Peak expression observed during early larval stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    1 embryo 16-18hr    0 embryo 18-20hr    2 embryo 20-22hr    87 embryo 22-24hr    72 larva L1    122 larva L2    106 larva L3 12hr old    35 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    3 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    0 pupae 2d postWPP    2 pupae 3d postWPP    4 pupae 4d postWPP    20 adult male 01day    70 adult male 05day    122 adult male 30day    76 adult female 01day    13 adult female 05day    5 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    1 embryo 16-18hr    0 embryo 18-20hr    2 embryo 20-22hr  (87) embryo 22-24hr  (72) larva L1  (122) larva L2  (106) larva L3 12hr old  (35) larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    3 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    0 pupae 2d postWPP    2 pupae 3d postWPP    4 pupae 4d postWPP    20 adult male 01day  (70) adult male 05day  (122) adult male 30day  (76) adult female 01day    13 adult female 05day    5 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    1 embryo 16-18hr    0 embryo 18-20hr    2 embryo 20-22hr    87 embryo 22-24hr    72 larva L1  (122) larva L2  106 larva L3 12hr old    35 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    3 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    0 pupae 2d postWPP    2 pupae 3d postWPP    4 pupae 4d postWPP    20 adult male 01day    70 adult male 05day  (122) adult male 30day    76 adult female 01day    13 adult female 05day    5 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    1 embryo 16-18hr    0 embryo 18-20hr    2 embryo 20-22hr    87 embryo 22-24hr    72 larva L1    122 larva L2    106 larva L3 12hr old    35 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    3 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    0 pupae 2d postWPP    2 pupae 3d postWPP    4 pupae 4d postWPP    20 adult male 01day    70 adult male 05day    122 adult male 30day    76 adult female 01day    13 adult female 05day    5 adult female 30day    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    1 embryo 16-18hr    0 embryo 18-20hr    2 embryo 20-22hr    87 embryo 22-24hr    72 larva L1    122 larva L2    106 larva L3 12hr old    35 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    3 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    0 pupae 2d postWPP    2 pupae 3d postWPP    4 pupae 4d postWPP    20 adult male 01day    70 adult male 05day    122 adult male 30day    76 adult female 01day    13 adult female 05day    5 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    1 embryo 16-18hr    0 embryo 18-20hr    2 embryo 20-22hr  (87) embryo 22-24hr  (72) larva L1  (122) larva L2  (106) larva L3 12hr old  (35) larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    3 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    0 pupae 2d postWPP    2 pupae 3d postWPP    4 pupae 4d postWPP    20 adult male 01day  (70) adult male 05day  (122) adult male 30day  (76) adult female 01day    13 adult female 05day    5 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    1 embryo 16-18hr    0 embryo 18-20hr    2 embryo 20-22hr    87 embryo 22-24hr    72 larva L1  122 larva L2  106 larva L3 12hr old    35 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    3 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    0 pupae 2d postWPP    2 pupae 3d postWPP    4 pupae 4d postWPP    20 adult male 01day    70 adult male 05day  122 adult male 30day    76 adult female 01day    13 adult female 05day    5 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    1 embryo 16-18hr    0 embryo 18-20hr    2 embryo 20-22hr    87 embryo 22-24hr    72 larva L1    122 larva L2    106 larva L3 12hr old    35 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    3 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    0 pupae 2d postWPP    2 pupae 3d postWPP    4 pupae 4d postWPP    20 adult male 01day    70 adult male 05day    122 adult male 30day    76 adult female 01day    13 adult female 05day    5 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    552 cold shock, 4-day adult    790 heat shock, 4-day adult    1116 Cadmium 50 mM 6 hrs, larvae L3    2184 Cadmium 50 mM 12 hrs, larvae L3    1551 Cadmium 50 mM 48 hrs, 4-day adult    1158 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    1017 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    681 Zinc 4.5 mM 48 hrs, 4-day adult    129 Ethanol 2.5% 3 hrs, larvae L3    65 Ethanol 5% 3 hrs, larvae L3    2221 Ethanol 10% 3 hrs, larvae L3    2025 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2321 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    442 Paraquat 5 mM 48 hrs, 4-day adult    92 Paraquat 10 mM 48 hrs, 4-day adult    75 Rotenone 2 μg 12 hrs, larvae L3    3220 Rotenone 8 μg 12 hrs, larvae L3    2736 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (552) cold shock, 4-day adult  (790) heat shock, 4-day adult  (1116) Cadmium 50 mM 6 hrs, larvae L3  (2184) Cadmium 50 mM 12 hrs, larvae L3  (1551) Cadmium 50 mM 48 hrs, 4-day adult  (1158) Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3  (1017) Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3  (681) Zinc 4.5 mM 48 hrs, 4-day adult  (129) Ethanol 2.5% 3 hrs, larvae L3  (65) Ethanol 5% 3 hrs, larvae L3  (2221) Ethanol 10% 3 hrs, larvae L3  (2025) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (2321) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  26 Caffeine 25 mg/ml 48 hrs, 4-day adult  (442) Paraquat 5 mM 48 hrs, 4-day adult  (92) Paraquat 10 mM 48 hrs, 4-day adult  (75) Rotenone 2 μg 12 hrs, larvae L3  (3220) Rotenone 8 μg 12 hrs, larvae L3  (2736) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (552) cold shock, 4-day adult  (790) heat shock, 4-day adult  (1116) Cadmium 50 mM 6 hrs, larvae L3  (2184) Cadmium 50 mM 12 hrs, larvae L3  (1551) Cadmium 50 mM 48 hrs, 4-day adult  (1158) Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3  (1017) Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3  (681) Zinc 4.5 mM 48 hrs, 4-day adult  (129) Ethanol 2.5% 3 hrs, larvae L3    65 Ethanol 5% 3 hrs, larvae L3  (2221) Ethanol 10% 3 hrs, larvae L3  (2025) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (2321) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult  (442) Paraquat 5 mM 48 hrs, 4-day adult    92 Paraquat 10 mM 48 hrs, 4-day adult    75 Rotenone 2 μg 12 hrs, larvae L3  (3220) Rotenone 8 μg 12 hrs, larvae L3  (2736) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    552 cold shock, 4-day adult    790 heat shock, 4-day adult    1116 Cadmium 50 mM 6 hrs, larvae L3    2184 Cadmium 50 mM 12 hrs, larvae L3    1551 Cadmium 50 mM 48 hrs, 4-day adult    1158 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    1017 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    681 Zinc 4.5 mM 48 hrs, 4-day adult    129 Ethanol 2.5% 3 hrs, larvae L3    65 Ethanol 5% 3 hrs, larvae L3    2221 Ethanol 10% 3 hrs, larvae L3    2025 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2321 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    442 Paraquat 5 mM 48 hrs, 4-day adult    92 Paraquat 10 mM 48 hrs, 4-day adult    75 Rotenone 2 μg 12 hrs, larvae L3    3220 Rotenone 8 μg 12 hrs, larvae L3    2736 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    552 cold shock, 4-day adult    790 heat shock, 4-day adult    1116 Cadmium 50 mM 6 hrs, larvae L3    2184 Cadmium 50 mM 12 hrs, larvae L3    1551 Cadmium 50 mM 48 hrs, 4-day adult    1158 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    1017 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    681 Zinc 4.5 mM 48 hrs, 4-day adult    129 Ethanol 2.5% 3 hrs, larvae L3    65 Ethanol 5% 3 hrs, larvae L3    2221 Ethanol 10% 3 hrs, larvae L3    2025 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2321 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    442 Paraquat 5 mM 48 hrs, 4-day adult    92 Paraquat 10 mM 48 hrs, 4-day adult    75 Rotenone 2 μg 12 hrs, larvae L3    3220 Rotenone 8 μg 12 hrs, larvae L3    2736 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (552) cold shock, 4-day adult  (790) heat shock, 4-day adult  (1116) Cadmium 50 mM 6 hrs, larvae L3  (2184) Cadmium 50 mM 12 hrs, larvae L3  (1551) Cadmium 50 mM 48 hrs, 4-day adult  (1158) Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3  (1017) Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3  (681) Zinc 4.5 mM 48 hrs, 4-day adult  (129) Ethanol 2.5% 3 hrs, larvae L3  (65) Ethanol 5% 3 hrs, larvae L3  (2221) Ethanol 10% 3 hrs, larvae L3  (2025) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (2321) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  26 Caffeine 25 mg/ml 48 hrs, 4-day adult  (442) Paraquat 5 mM 48 hrs, 4-day adult  (92) Paraquat 10 mM 48 hrs, 4-day adult  (75) Rotenone 2 μg 12 hrs, larvae L3  (3220) Rotenone 8 μg 12 hrs, larvae L3  (2736) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (552) cold shock, 4-day adult  (790) heat shock, 4-day adult  (1116) Cadmium 50 mM 6 hrs, larvae L3  (2184) Cadmium 50 mM 12 hrs, larvae L3  (1551) Cadmium 50 mM 48 hrs, 4-day adult  (1158) Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3  (1017) Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3  (681) Zinc 4.5 mM 48 hrs, 4-day adult  129 Ethanol 2.5% 3 hrs, larvae L3    65 Ethanol 5% 3 hrs, larvae L3  (2221) Ethanol 10% 3 hrs, larvae L3  (2025) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (2321) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult  (442) Paraquat 5 mM 48 hrs, 4-day adult    92 Paraquat 10 mM 48 hrs, 4-day adult    75 Rotenone 2 μg 12 hrs, larvae L3  (3220) Rotenone 8 μg 12 hrs, larvae L3  (2736) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    552 cold shock, 4-day adult    790 heat shock, 4-day adult    1116 Cadmium 50 mM 6 hrs, larvae L3    2184 Cadmium 50 mM 12 hrs, larvae L3    1551 Cadmium 50 mM 48 hrs, 4-day adult    1158 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    1017 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    681 Zinc 4.5 mM 48 hrs, 4-day adult    129 Ethanol 2.5% 3 hrs, larvae L3    65 Ethanol 5% 3 hrs, larvae L3    2221 Ethanol 10% 3 hrs, larvae L3    2025 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2321 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    442 Paraquat 5 mM 48 hrs, 4-day adult    92 Paraquat 10 mM 48 hrs, 4-day adult    75 Rotenone 2 μg 12 hrs, larvae L3    3220 Rotenone 8 μg 12 hrs, larvae L3    2736 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_16 mE1_20_mRNA_expression_cluster_16
External Data & Images
Linkouts	BDGP expression data • LP07339 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004428
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of LysE Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of LysE Class Mutagen Stocks Known lesion LysEKK115954 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5895} NA P{KK115954} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
lysozyme activity inferred from electronic annotation with InterPro:IPR000974 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Daffre et al., 1994) non-traceable author statement (Lemaitre, 2000.12.20, Swiss-Prot Project Members, 1994.10.1)
Biological Process
CV term Evidence References
antimicrobial humoral response non-traceable author statement (Lemaitre, 2000.12.20) cell wall macromolecule catabolic process inferred from electronic annotation with InterPro:IPR000974 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions LysE allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63674 DroID - A comprehensive database of gene and protein interactions. • FBgn0004428 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38128
Orthologs
OrthoDB Orthologs (81) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6GMVHJ Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search EOG69KTM4
Orthologs in Drosophila Species (EOG6GMVHJ)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\LysE     Drosophila melanogaster fruit fly  Dmel\LysD     Drosophila melanogaster fruit fly  Dmel\LysC     Drosophila melanogaster fruit fly  Dmel\LysB     Drosophila simulans   Dsim\GD13593   Y Drosophila simulans   Dsim\GD13594   Y Drosophila sechellia   Dsec\GM14380   Y Drosophila sechellia   Dsec\GM14378   Y Drosophila sechellia   Dsec\GM14382   Y Drosophila sechellia   Dsec\GM14229   Y Drosophila erecta   Dere\GG14762   Y Drosophila erecta   Dere\GG19823   Y Drosophila erecta   Dere\GG19822   Y Drosophila erecta   Dere\GG14617   Y Drosophila erecta   Dere\GG14759   Y Drosophila yakuba   Dyak\GE21123   Y Drosophila yakuba   Dyak\GE20977   Y Drosophila yakuba   Dyak\GE21124   Y Drosophila yakuba   Dyak\GE21125   Y Drosophila ananassae   Dana\GF10072   Y Drosophila ananassae   Dana\GF24436   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA28405   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA28485   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA28406   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA28484   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA28408   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA28483   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA28404   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA28409   Y Drosophila persimilis   Dper\GL21426   Y Drosophila persimilis   Dper\GL16157   Y Drosophila persimilis   Dper\GL16159   Y Drosophila persimilis   Dper\GL16083   Y Drosophila persimilis   Dper\GL16691   Y Drosophila persimilis   Dper\GL14512   Y Drosophila persimilis   Dper\GL16158   Y Drosophila persimilis   Dper\GL16156   Y Drosophila willistoni   Dwil\GK21106   Y Drosophila willistoni   Dwil\GK21095   Y Drosophila willistoni   Dwil\GK12154   Y Drosophila willistoni   Dwil\GK12260   Y Drosophila willistoni   Dwil\GK21084   Y Drosophila virilis   Dvir\GJ12895   Y Drosophila virilis   Dvir\GJ12507   Y Drosophila virilis   Dvir\GJ12508   Y Drosophila mojavensis   Dmoj\GI16761   Y Drosophila mojavensis   Dmoj\GI16638   Y Drosophila mojavensis   Dmoj\GI16637   Y Drosophila mojavensis   Dmoj\GI16762   Y Drosophila mojavensis   Dmoj\GI16643   Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (EOG69KTM4)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Danio rerio Zebrafish  Drer\lyz Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000031036 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000013041 Y Xenopus tropicalis Western clawed frog  Xtro\mgc89221 Y Gallus gallus Domestic chicken  Ggal\LYZ Y Mus musculus House mouse  Mmus\Spaca5 Y Mus musculus House mouse  Mmus\9530003J23Rik Y Mus musculus House mouse  Mmus\Lyzl6 Y Mus musculus House mouse  Mmus\Lyz1 Y Mus musculus House mouse  Mmus\Lalba Y Mus musculus House mouse  Mmus\Lyzl4 Y Mus musculus House mouse  Mmus\Lyzl1 Y Mus musculus House mouse  Mmus\Lyz2 Y Mus musculus House mouse  Mmus\ENSMUSG00000053184 Y Rattus norvegicus Norway rat  Rnor\Lyzl1 Y Rattus norvegicus Norway rat  Rnor\Lyz2 Y Rattus norvegicus Norway rat  Rnor\Spaca3 Y Rattus norvegicus Norway rat  Rnor\Lyzl6 Y Rattus norvegicus Norway rat  Rnor\RGD1306474 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000034139 Y Rattus norvegicus Norway rat  Rnor\Lyzl4 Y Rattus norvegicus Norway rat  Rnor\Lalba Y Homo sapiens Human  Hsap\LYZ Y Homo sapiens Human  Hsap\LALBA Y Homo sapiens Human  Hsap\LYZL4 Y Homo sapiens Human  Hsap\LYZL6 Y Homo sapiens Human  Hsap\ENSG00000171489 Y Homo sapiens Human  Hsap\ENSG00000120563 Y Homo sapiens Human  Hsap\ENSG00000171478 Y Homo sapiens Human  Hsap\ENSG00000151033 Y Homo sapiens Human  Hsap\SPACA3 Y
Human Orthologs (9)
Gene OMIM HGNC Hsap\LYZ     Hsap\LALBA     Hsap\LYZL4     Hsap\LYZL6     Hsap\ENSG00000171489     Hsap\ENSG00000120563     Hsap\ENSG00000171478     Hsap\ENSG00000151033     Hsap\SPACA3
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 0 )
Genomic Clones ( 1 )
	BACR22D12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 9 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LP06719 LP07339
Other clones	IP21038 IP21338 MIP11624 RT03813 yak-ad_LysS
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	EC13321 EC39521
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004428 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38128
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: LysE BcDNA:LP07339 (FlyBase, 1996-)
Additional comments	Source for merge of LysE BcDNA:LP07339 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
	The strain whose genome sequence is reported in FBrf0155827 is mutant at LysC, not LysE as was reported on page 19 of FBrf0155827. (Misra, 2004.1.7) FlyBase curator comment: The reference to "LysE" on page 19 is a typographical error - the gene meant is LysC. See Misra, 2004.1.7, personal communication to FlyBase. (Misra et al., 2002) Lysozymes are expressed at a high level mainly in the digestive tract, they are not a component of the haemolymph. Lysozyme is not induced by bacteria so is not part of the inducible immune response but instead has been recruited for digestion of symbiotic bacteria in the stomach. (Daffre et al., 1994)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057479 RefSeq (Proteins) • NP_476827 DDBJ / EMBL / GenBank • AAF47451 AAM50919 AC004489 AC005847 AI294047 AY119059 CAA80229 Z22227 Entrez Gene - A searchable database of RefSeq genes. • 38128 UniProtKB/Swiss-Prot • P37159
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Glycoside hydrolase, family 22, lysozyme (IPR000974) Glycoside hydrolase, family 22 (IPR001916) Glycoside hydrolase, family 22, conserved site (IPR019799) Lysozyme-like domain (IPR023346) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LP07339
Linkouts
	BioGRID - A database of protein and genetic interactions • 63674 DroID - A comprehensive database of gene and protein interactions. • FBgn0004428 DRSC - Results from RNAi screens. • FBgn0004428 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004428 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004428 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38128 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38128 modMine - Data generated by the modENCODE project. • FBgn0004428
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	BcDNA:LP07339   CG1180 (Li et al., 2009, Keleman et al., 2009.8.5) LysE (Waterhouse et al., 2007, Conant and Wagner, 2003, Rynes et al., 2012, Kwon et al., 2008, Yan et al., 2008, Li et al., 2009, Cronin et al., 2009, Greene et al., 2005, Blanco et al., 2008, Paré et al., 2012) lysE (Lemaitre, 2000.12.20, Zsindely et al., 2009) Lys E (Roxstrom-Lindquist et al., 2004)
Name Synonym	Lysozyme E (Rollmann et al., 2008, McGraw et al., 2008, Hurlbut et al., 2009, Roxstrom-Lindquist et al., 2004)
Secondary FlyBase IDs
	FBgn0002575 FBgn0063103
References ( 40 )
Generate a list of	All references relating to this gene ( 40 )
List References by type	Research paper  ( 22 ) Supplementary material  ( 2 ) Review  ( 4 ) Personal communication to FlyBase  ( 5 ) FlyBase analysis  ( 2 ) Protein sequence record  ( 1 ) Curated genome annotation  ( 3 ) Thesis  ( 1 )
Recent research papers ( 2 )
	Paré et al., 2012, PLoS ONE 7(5): e36254 The functions of grainy head-like proteins in animals and fungi and the evolution of apical extracellular barriers. [FBrf0218280] Rynes et al., 2012, Mol. Cell. Biol. 32(19): 3949--3962 Activating transcription factor 3 regulates immune and metabolic homeostasis. [FBrf0219385] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...