• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Cyp1

General Information
Symbol	Dmel\Cyp1	Species	D. melanogaster
Name	Cyclophilin 1	Annotation symbol	CG9916
Feature type	protein_coding_gene	FlyBase ID	FBgn0004432
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	cyp-1, Cpy1
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	14B9-14B12	Sequence location	X:16,211,706..16,214,403 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Cyclophilin 1 is referred to in FlyBase by the symbol Dmel\Cyp1 (CG9916, FBgn0004432). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: peptidyl-prolyl cis-trans isomerase activity. There is experimental evidence that it is involved in the biological process: autophagic cell death; salivary gland cell autophagic cell death. 8 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has one annotated transcript and one annotated polypeptide. Protein features are: Cyclophilin-like peptidyl-prolyl cis-trans isomerase domain; Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site. Summary of modENCODE Temporal Expression Profile: Very high expression at all stages of development. Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1638036_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Cyp1. Gene sequence location is X:16211706..16214403.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 14B9-14B12   Limits computationally determined from genome sequence between P{EP}kat80EP620&P{EP}cazEP1564 and P{EP}Cyp1EP1073&P{EP}Dsp1EP355
Experimentally Determined Cytological Location
Cytogenetic map Notes References 14B11-14B12   (determined by in situ hybridisation)   (Rutherford, 1996.11.4)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Cyp1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.48 Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.50
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Cyp1-RA FBtr0074238  NM_078642   1227   227
Additional Transcript Data & Comments
Reported size (kB)	1.0, 0.7 (unknown) (Stamnes et al., 1991)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Cyp1-PA   FBpp0074017   24.7   227   9.71     NP_523366   AAF48589
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cyclophilin-like peptidyl-prolyl cis-trans isomerase domain (IPR002130) Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site (IPR020892)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA441052   AA538793   AA696458   AA697172   AA697206   AA736090   AA801799   AA802795   AA942625   AE014298 AAF48589   AI061993   AI063251   AI114154   AI237932   AI297544   AI388897   AI403043   AI403389   AI513744   AI530979   AI531951   AI944424   AQ025378   AW941965   AW944203   AY060962 AAL28510   AY231912   AY232025   AY432659   AY440343   BE976413   BF502042   BG637526   BG639306   BG639329   BI161950   BI162497   BI162498   BI162615   BI162616   BI165251   BI165922   BI165939   BI167782   BI169108   BI170692   BI173901   BI173936   BI213351   BI213710   BI215365   BI215408   BI216441   BI227745   BI227751   BI228389   BI229114   BI230543   BI231141   BI231196   BI233203   BI235116   BI236605   BI238268   BI240246   BI241858   BI242885   BI243053   BI243608   BI353361   BI354031   BI354663   BI354761   BI355356   BI355880   BI363921   BI364857   BI365480   BI370665   BI373128   BI373165   BI373727   BI375928   BI482612   BI482724   BI484166   BI484622   BI485482   BI486008   BI564344   BI564527   BI564810   BI565047   BI565450   BI566459   BI566465   BI566592   BI566757   BI568228   BI572076   BI573934   BI573935   BI574581   BI574840   BI578140   BI579123   BI579234   BI579980   BI584044   BI584170   BI585824   BI586819   BI586959   BI586962   BI587154   BI590955   BI590970   BI590976   BI592589   BI604544   BI604900   BI605811   BI605965   BI607018   BI607890   BI608809   BI609272   BI609356   BI610813   BI611518   BI611627   BI612917   BI613497   BI615646   BI616601   BI616891   BI617890   BI621360   BI622082   BI622821   BI623059   BI628643   BI629111   BI629534   BI630735   BI631251   BI634987   BI636035   BI639064   BI639720   BI640442   BI641002   BI641310   BP540428   BP542430   BP542704   BP544580   BP544581   BP544588   BP544589   BP545280   BP545281   BP545722   BP545723   BP545995   BP546555   BP546804   BP547206   BP550367   BP550368   BP550506   BP550507   BP551594   BP552252   BP552253   BP552742   BP552743   BP552845   BP552998   BP552999   BP554159   BP554160   BP554386   BP554553   BP554554   BP555380   BP555381   BP555775   BP555776   BP558043   BP558044   BP558161   BP558162   BP558510   BP558511   BP559175   BP559176   BP559496   BP559497   BP559506   BP559507   BQ103160   BT009946 AAQ22415   BT031016   BX006580   BX008702   BX011227   BX013233   BX014873   BX024694   BX046149   BX050608   BX057302   BX069873   CA806348   CA806379   CK658958   CK659231   CO152768   CO153860   CO154615   CO155890   CO176785   CO177860   CO180900   CO181477   CO181867   CO186319   CO188141   CO189916   CO191818   CO191976   CO192825   CO193041   CO194792   CO195394   CO263710   CO268731   CO269673   CO272324   CO273925   CO277838   CO282716   CO285758   CO288181   CO295612   CO295798   CO300844   CO308618   CO313256   CO318072   CO335857   CO335941   CO337833   CO341262   CO341304   DQ440025   EC057736   EC058123   EC066289   EC071320   EC071811   EC075502   EC082412   EC085059   EC088067   EC201542   EC206697   EC218791   EC218969   EC219854   EC222281   EC223185   EC225770   EC231625   EC236355   EC237314   EC240520   EC241294   EC243896   EC247675   EC250053   EC258259   EC259361   EC260909   EC260965   EC261122   EC262844   EC263426   EC263924   EC264129   EC264139   EC265119   EC265381   EC265772   EC266986   EL873667   EL873668   EL886439   ES691988   EV574917   EV575465   EV575877   EV575998   EV577594   EV578151   EV578369   EV578413   EV578643   EV578832   EV579043   EV579472   EV579959   EV580239   EV580512   EV580564   EV580570   EV581191   EV581345   EV582031   EV582310   EV582335   EV582508   EV582598   EV582735   EV583189   EV583414   EV583601   EV584077   EV584824   EV585740   EV586174   EV586310   EV586700   EV586818   EV586937   EV588025   EV589094   EV590349   EV590827   EV591013   EV591023   EV591730   EV592096   EV592399   EV594047   EV594504   EV594777   EV595223   EV595348   EV595437   EV596127   EV596946   EV597087   EV597387   EV597934   EV598539   EV598693   EV598708   EV598857   EV599722   EV600361   EV600436   EV600694   M62398 AAB03701   Z32274
UniProtKB/Swiss-Prot	P25007
UniProtKB/TrEMBL	Q95S46
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) pole cell   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) pole cell   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 13 -- 16   dorsal pharyngeal muscle   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
	The 0.7kb and 1.0kb Cyp1 transcripts are present at all developmental stages but display different tissue distribution. The 0.7kb transcript is abundant in adult bodies but not heads and the 1.0kb transcript is at low levels in both. (Stamnes et al., 1991)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   wing disc   (Santaren et al., 1993) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2183.25 Larval Midgut    2563.2 Larval Hindgut    3056.2 Larval Malpighian Tubules    3602.7 Larval Fat Body    3403.7 Larval Salivary Gland    4192.3 Larval Trachea    4281.825 Larval Carcass    3337.6 Adult Head    2388 Adult Eye    2719.625 Adult Brain    1826.5 Adult Thoracic-Abdominal Ganglion    2218.1 Adult Crop    3769.2 Adult Midgut    3276.1 Adult Hindgut    3601 Adult Malpighian Tubules    3996.5 Adult Fat Body    3469.9 Adult Salivary Gland    4280.6 Adult Heart    4049.8 Adult VirginFemale Spermatheca    3016.1 Adult InseminatedFemale Spermatheca    2822.1 Adult Ovary    2710.5 Adult Testis    506.4 Adult Male Accessory Gland    4150.4 Adult Carcass    3241.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2183.25) Larval Midgut  (2563.2) Larval Hindgut  (3056.2) Larval Malpighian Tubules  (3602.7) Larval Fat Body  (3403.7) Larval Salivary Gland  (4192.3) Larval Trachea  (4281.825) Larval Carcass  (3337.6) Adult Head  (2388) Adult Eye  (2719.625) Adult Brain  (1826.5) Adult Thoracic-Abdominal Ganglion  (2218.1) Adult Crop  (3769.2) Adult Midgut  (3276.1) Adult Hindgut  (3601) Adult Malpighian Tubules  (3996.5) Adult Fat Body  (3469.9) Adult Salivary Gland  (4280.6) Adult Heart  (4049.8) Adult VirginFemale Spermatheca  (3016.1) Adult InseminatedFemale Spermatheca  (2822.1) Adult Ovary  (2710.5) Adult Testis  506.4 Adult Male Accessory Gland  (4150.4) Adult Carcass  (3241.4) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2183.25) Larval Midgut  (2563.2) Larval Hindgut  (3056.2) Larval Malpighian Tubules  (3602.7) Larval Fat Body  (3403.7) Larval Salivary Gland  (4192.3) Larval Trachea  (4281.825) Larval Carcass  (3337.6) Adult Head  (2388) Adult Eye  (2719.625) Adult Brain  (1826.5) Adult Thoracic-Abdominal Ganglion  (2218.1) Adult Crop  (3769.2) Adult Midgut  (3276.1) Adult Hindgut  (3601) Adult Malpighian Tubules  (3996.5) Adult Fat Body  (3469.9) Adult Salivary Gland  (4280.6) Adult Heart  (4049.8) Adult VirginFemale Spermatheca  (3016.1) Adult InseminatedFemale Spermatheca  (2822.1) Adult Ovary  (2710.5) Adult Testis    506.4 Adult Male Accessory Gland  (4150.4) Adult Carcass  (3241.4) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2183.25 Larval Midgut    2563.2 Larval Hindgut    3056.2 Larval Malpighian Tubules    3602.7 Larval Fat Body    3403.7 Larval Salivary Gland    4192.3 Larval Trachea    4281.825 Larval Carcass    3337.6 Adult Head    2388 Adult Eye    2719.625 Adult Brain    1826.5 Adult Thoracic-Abdominal Ganglion    2218.1 Adult Crop    3769.2 Adult Midgut    3276.1 Adult Hindgut    3601 Adult Malpighian Tubules    3996.5 Adult Fat Body    3469.9 Adult Salivary Gland    4280.6 Adult Heart    4049.8 Adult VirginFemale Spermatheca    3016.1 Adult InseminatedFemale Spermatheca    2822.1 Adult Ovary    2710.5 Adult Testis    506.4 Adult Male Accessory Gland    4150.4 Adult Carcass    3241.4 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2183.25 Larval Midgut    2563.2 Larval Hindgut    3056.2 Larval Malpighian Tubules    3602.7 Larval Fat Body    3403.7 Larval Salivary Gland    4192.3 Larval Trachea    4281.825 Larval Carcass    3337.6 Adult Head    2388 Adult Eye    2719.625 Adult Brain    1826.5 Adult Thoracic-Abdominal Ganglion    2218.1 Adult Crop    3769.2 Adult Midgut    3276.1 Adult Hindgut    3601 Adult Malpighian Tubules    3996.5 Adult Fat Body    3469.9 Adult Salivary Gland    4280.6 Adult Heart    4049.8 Adult VirginFemale Spermatheca    3016.1 Adult InseminatedFemale Spermatheca    2822.1 Adult Ovary    2710.5 Adult Testis    506.4 Adult Male Accessory Gland    4150.4 Adult Carcass    3241.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2183.25) Larval Midgut  (2563.2) Larval Hindgut  (3056.2) Larval Malpighian Tubules  (3602.7) Larval Fat Body  (3403.7) Larval Salivary Gland  (4192.3) Larval Trachea  (4281.825) Larval Carcass  (3337.6) Adult Head  (2388) Adult Eye  (2719.625) Adult Brain  (1826.5) Adult Thoracic-Abdominal Ganglion  (2218.1) Adult Crop  (3769.2) Adult Midgut  (3276.1) Adult Hindgut  (3601) Adult Malpighian Tubules  (3996.5) Adult Fat Body  (3469.9) Adult Salivary Gland  (4280.6) Adult Heart  (4049.8) Adult VirginFemale Spermatheca  (3016.1) Adult InseminatedFemale Spermatheca  (2822.1) Adult Ovary  (2710.5) Adult Testis  506.4 Adult Male Accessory Gland  (4150.4) Adult Carcass  (3241.4) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2183.25) Larval Midgut  (2563.2) Larval Hindgut  (3056.2) Larval Malpighian Tubules  (3602.7) Larval Fat Body  (3403.7) Larval Salivary Gland  (4192.3) Larval Trachea  (4281.825) Larval Carcass  (3337.6) Adult Head  (2388) Adult Eye  (2719.625) Adult Brain  (1826.5) Adult Thoracic-Abdominal Ganglion  (2218.1) Adult Crop  (3769.2) Adult Midgut  (3276.1) Adult Hindgut  (3601) Adult Malpighian Tubules  (3996.5) Adult Fat Body  (3469.9) Adult Salivary Gland  (4280.6) Adult Heart  (4049.8) Adult VirginFemale Spermatheca  (3016.1) Adult InseminatedFemale Spermatheca  (2822.1) Adult Ovary  (2710.5) Adult Testis    506.4 Adult Male Accessory Gland  (4150.4) Adult Carcass  (3241.4) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2183.25 Larval Midgut    2563.2 Larval Hindgut    3056.2 Larval Malpighian Tubules    3602.7 Larval Fat Body    3403.7 Larval Salivary Gland    4192.3 Larval Trachea    4281.825 Larval Carcass    3337.6 Adult Head    2388 Adult Eye    2719.625 Adult Brain    1826.5 Adult Thoracic-Abdominal Ganglion    2218.1 Adult Crop    3769.2 Adult Midgut    3276.1 Adult Hindgut    3601 Adult Malpighian Tubules    3996.5 Adult Fat Body    3469.9 Adult Salivary Gland    4280.6 Adult Heart    4049.8 Adult VirginFemale Spermatheca    3016.1 Adult InseminatedFemale Spermatheca    2822.1 Adult Ovary    2710.5 Adult Testis    506.4 Adult Male Accessory Gland    4150.4 Adult Carcass    3241.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    2388   NA  Eye    2719.625   NA  Brain    1826.5   2183.25  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    2218.1   NA  Crop    3769.2   2563.2  Midgut    3276.1   3056.2  Hindgut    3601   3602.7  Malpighian Tubules    3996.5   3403.7  Fat Body    3469.9   4192.3  Salivary Gland    4280.6   NA  Heart    4049.8   4281.825  Trachea    NA   NA  VirginFemale Spermatheca    3016.1   NA  InseminatedFemale Spermatheca    2822.1   NA  Ovary    2710.5   NA  Testis    506.4   NA  Male Accessory Gland    4150.4   3337.6  Carcass    3241.4 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    475 central nervous system, larvae L3    351 central nervous system, pupae P8    253 head, virgin 1-day female    167 head, virgin 4-day female    150 head, virgin 20-day female    234 head, mated 1-day female    106 head, mated 4-day female    110 head, mated 20-day female    194 head, mated 1-day male    154 head, mated 4-day male    167 head, mated 20-day male    217 salivary gland, larvae L3 wandering    84 salivary gland, white prepupae    151 digestive system, larvae L3 wandering    230 digestive system, 1-day adult    250 digestive system, 4-day adult    187 digestive system, 20-day adult    231 fat body, larvae L3 wandering    78 fat body, white prepupae    133 fat body, pupae P8    179 carcass, larvae L3 wandering    402 carcass, 1-day adult    128 carcass, 4-day adult    164 carcass, 20-day adult    222 ovary, virgin 4-day female    557 ovary, mated 4-day female    379 testis, mated 4-day male    87 accessory gland, mated 4-day male    169 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (475) central nervous system, larvae L3  (351) central nervous system, pupae P8  (253) head, virgin 1-day female  (167) head, virgin 4-day female  (150) head, virgin 20-day female  (234) head, mated 1-day female  (106) head, mated 4-day female  (110) head, mated 20-day female  (194) head, mated 1-day male  (154) head, mated 4-day male  (167) head, mated 20-day male  (217) salivary gland, larvae L3 wandering  (84) salivary gland, white prepupae  (151) digestive system, larvae L3 wandering  (230) digestive system, 1-day adult  (250) digestive system, 4-day adult  (187) digestive system, 20-day adult  (231) fat body, larvae L3 wandering  (78) fat body, white prepupae  (133) fat body, pupae P8  (179) carcass, larvae L3 wandering  (402) carcass, 1-day adult  (128) carcass, 4-day adult  (164) carcass, 20-day adult  (222) ovary, virgin 4-day female  (557) ovary, mated 4-day female  (379) testis, mated 4-day male  (87) accessory gland, mated 4-day male  (169) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (475) central nervous system, larvae L3  (351) central nervous system, pupae P8  (253) head, virgin 1-day female  (167) head, virgin 4-day female  (150) head, virgin 20-day female  (234) head, mated 1-day female  106 head, mated 4-day female  (110) head, mated 20-day female  (194) head, mated 1-day male  (154) head, mated 4-day male  (167) head, mated 20-day male  (217) salivary gland, larvae L3 wandering    84 salivary gland, white prepupae  (151) digestive system, larvae L3 wandering  (230) digestive system, 1-day adult  (250) digestive system, 4-day adult  (187) digestive system, 20-day adult  (231) fat body, larvae L3 wandering    78 fat body, white prepupae  (133) fat body, pupae P8  (179) carcass, larvae L3 wandering  (402) carcass, 1-day adult  (128) carcass, 4-day adult  (164) carcass, 20-day adult  (222) ovary, virgin 4-day female  (557) ovary, mated 4-day female  (379) testis, mated 4-day male    87 accessory gland, mated 4-day male  (169) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    475 central nervous system, larvae L3    351 central nervous system, pupae P8    253 head, virgin 1-day female    167 head, virgin 4-day female    150 head, virgin 20-day female    234 head, mated 1-day female    106 head, mated 4-day female    110 head, mated 20-day female    194 head, mated 1-day male    154 head, mated 4-day male    167 head, mated 20-day male    217 salivary gland, larvae L3 wandering    84 salivary gland, white prepupae    151 digestive system, larvae L3 wandering    230 digestive system, 1-day adult    250 digestive system, 4-day adult    187 digestive system, 20-day adult    231 fat body, larvae L3 wandering    78 fat body, white prepupae    133 fat body, pupae P8    179 carcass, larvae L3 wandering    402 carcass, 1-day adult    128 carcass, 4-day adult    164 carcass, 20-day adult    222 ovary, virgin 4-day female    557 ovary, mated 4-day female    379 testis, mated 4-day male    87 accessory gland, mated 4-day male    169 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    475 central nervous system, larvae L3    351 central nervous system, pupae P8    253 head, virgin 1-day female    167 head, virgin 4-day female    150 head, virgin 20-day female    234 head, mated 1-day female    106 head, mated 4-day female    110 head, mated 20-day female    194 head, mated 1-day male    154 head, mated 4-day male    167 head, mated 20-day male    217 salivary gland, larvae L3 wandering    84 salivary gland, white prepupae    151 digestive system, larvae L3 wandering    230 digestive system, 1-day adult    250 digestive system, 4-day adult    187 digestive system, 20-day adult    231 fat body, larvae L3 wandering    78 fat body, white prepupae    133 fat body, pupae P8    179 carcass, larvae L3 wandering    402 carcass, 1-day adult    128 carcass, 4-day adult    164 carcass, 20-day adult    222 ovary, virgin 4-day female    557 ovary, mated 4-day female    379 testis, mated 4-day male    87 accessory gland, mated 4-day male    169 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (475) central nervous system, larvae L3  (351) central nervous system, pupae P8  (253) head, virgin 1-day female  (167) head, virgin 4-day female  (150) head, virgin 20-day female  (234) head, mated 1-day female  (106) head, mated 4-day female  (110) head, mated 20-day female  (194) head, mated 1-day male  (154) head, mated 4-day male  (167) head, mated 20-day male  (217) salivary gland, larvae L3 wandering  (84) salivary gland, white prepupae  (151) digestive system, larvae L3 wandering  (230) digestive system, 1-day adult  (250) digestive system, 4-day adult  (187) digestive system, 20-day adult  (231) fat body, larvae L3 wandering  (78) fat body, white prepupae  (133) fat body, pupae P8  (179) carcass, larvae L3 wandering  (402) carcass, 1-day adult  (128) carcass, 4-day adult  (164) carcass, 20-day adult  (222) ovary, virgin 4-day female  (557) ovary, mated 4-day female  (379) testis, mated 4-day male  (87) accessory gland, mated 4-day male  (169) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (475) central nervous system, larvae L3  (351) central nervous system, pupae P8  (253) head, virgin 1-day female  (167) head, virgin 4-day female  (150) head, virgin 20-day female  (234) head, mated 1-day female  106 head, mated 4-day female  110 head, mated 20-day female  (194) head, mated 1-day male  (154) head, mated 4-day male  (167) head, mated 20-day male  (217) salivary gland, larvae L3 wandering    84 salivary gland, white prepupae  (151) digestive system, larvae L3 wandering  (230) digestive system, 1-day adult  (250) digestive system, 4-day adult  (187) digestive system, 20-day adult  (231) fat body, larvae L3 wandering    78 fat body, white prepupae  133 fat body, pupae P8  (179) carcass, larvae L3 wandering  (402) carcass, 1-day adult  128 carcass, 4-day adult  (164) carcass, 20-day adult  (222) ovary, virgin 4-day female  (557) ovary, mated 4-day female  (379) testis, mated 4-day male    87 accessory gland, mated 4-day male  (169) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    475 central nervous system, larvae L3    351 central nervous system, pupae P8    253 head, virgin 1-day female    167 head, virgin 4-day female    150 head, virgin 20-day female    234 head, mated 1-day female    106 head, mated 4-day female    110 head, mated 20-day female    194 head, mated 1-day male    154 head, mated 4-day male    167 head, mated 20-day male    217 salivary gland, larvae L3 wandering    84 salivary gland, white prepupae    151 digestive system, larvae L3 wandering    230 digestive system, 1-day adult    250 digestive system, 4-day adult    187 digestive system, 20-day adult    231 fat body, larvae L3 wandering    78 fat body, white prepupae    133 fat body, pupae P8    179 carcass, larvae L3 wandering    402 carcass, 1-day adult    128 carcass, 4-day adult    164 carcass, 20-day adult    222 ovary, virgin 4-day female    557 ovary, mated 4-day female    379 testis, mated 4-day male    87 accessory gland, mated 4-day male    169 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Very high expression at all stages of development. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    914 embryo 02-04hr    229 embryo 04-06hr    210 embryo 06-08hr    388 embryo 08-10hr    461 embryo 10-12hr    519 embryo 12-14hr    335 embryo 14-16hr    238 embryo 16-18hr    220 embryo 18-20hr    178 embryo 20-22hr    190 embryo 22-24hr    180 larva L1    406 larva L2    623 larva L3 12hr old    562 larva L3 puffstage 1-2    499 larva L3 puffstage 3-6    552 larva L3 puffstage 7-9    665 white prepupae new    613 white prepupae 12hr    389 white prepupae 24hr    482 pupae 2d postWPP    386 pupae 3d postWPP    283 pupae 4d postWPP    207 adult male 01day    281 adult male 05day    306 adult male 30day    236 adult female 01day    611 adult female 05day    976 adult female 30day    989 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (914) embryo 02-04hr  (229) embryo 04-06hr  (210) embryo 06-08hr  (388) embryo 08-10hr  (461) embryo 10-12hr  (519) embryo 12-14hr  (335) embryo 14-16hr  (238) embryo 16-18hr  (220) embryo 18-20hr  (178) embryo 20-22hr  (190) embryo 22-24hr  (180) larva L1  (406) larva L2  (623) larva L3 12hr old  (562) larva L3 puffstage 1-2  (499) larva L3 puffstage 3-6  (552) larva L3 puffstage 7-9  (665) white prepupae new  (613) white prepupae 12hr  (389) white prepupae 24hr  (482) pupae 2d postWPP  (386) pupae 3d postWPP  (283) pupae 4d postWPP  (207) adult male 01day  (281) adult male 05day  (306) adult male 30day  (236) adult female 01day  (611) adult female 05day  (976) adult female 30day  (989) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (914) embryo 02-04hr  (229) embryo 04-06hr  (210) embryo 06-08hr  (388) embryo 08-10hr  (461) embryo 10-12hr  (519) embryo 12-14hr  (335) embryo 14-16hr  (238) embryo 16-18hr  (220) embryo 18-20hr  (178) embryo 20-22hr  (190) embryo 22-24hr  (180) larva L1  (406) larva L2  (623) larva L3 12hr old  (562) larva L3 puffstage 1-2  (499) larva L3 puffstage 3-6  (552) larva L3 puffstage 7-9  (665) white prepupae new  (613) white prepupae 12hr  (389) white prepupae 24hr  (482) pupae 2d postWPP  (386) pupae 3d postWPP  (283) pupae 4d postWPP  (207) adult male 01day  (281) adult male 05day  (306) adult male 30day  (236) adult female 01day  (611) adult female 05day  (976) adult female 30day  (989) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    914 embryo 02-04hr    229 embryo 04-06hr    210 embryo 06-08hr    388 embryo 08-10hr    461 embryo 10-12hr    519 embryo 12-14hr    335 embryo 14-16hr    238 embryo 16-18hr    220 embryo 18-20hr    178 embryo 20-22hr    190 embryo 22-24hr    180 larva L1    406 larva L2    623 larva L3 12hr old    562 larva L3 puffstage 1-2    499 larva L3 puffstage 3-6    552 larva L3 puffstage 7-9    665 white prepupae new    613 white prepupae 12hr    389 white prepupae 24hr    482 pupae 2d postWPP    386 pupae 3d postWPP    283 pupae 4d postWPP    207 adult male 01day    281 adult male 05day    306 adult male 30day    236 adult female 01day    611 adult female 05day    976 adult female 30day    989 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    914 embryo 02-04hr    229 embryo 04-06hr    210 embryo 06-08hr    388 embryo 08-10hr    461 embryo 10-12hr    519 embryo 12-14hr    335 embryo 14-16hr    238 embryo 16-18hr    220 embryo 18-20hr    178 embryo 20-22hr    190 embryo 22-24hr    180 larva L1    406 larva L2    623 larva L3 12hr old    562 larva L3 puffstage 1-2    499 larva L3 puffstage 3-6    552 larva L3 puffstage 7-9    665 white prepupae new    613 white prepupae 12hr    389 white prepupae 24hr    482 pupae 2d postWPP    386 pupae 3d postWPP    283 pupae 4d postWPP    207 adult male 01day    281 adult male 05day    306 adult male 30day    236 adult female 01day    611 adult female 05day    976 adult female 30day    989 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (914) embryo 02-04hr  (229) embryo 04-06hr  (210) embryo 06-08hr  (388) embryo 08-10hr  (461) embryo 10-12hr  (519) embryo 12-14hr  (335) embryo 14-16hr  (238) embryo 16-18hr  (220) embryo 18-20hr  (178) embryo 20-22hr  (190) embryo 22-24hr  (180) larva L1  (406) larva L2  (623) larva L3 12hr old  (562) larva L3 puffstage 1-2  (499) larva L3 puffstage 3-6  (552) larva L3 puffstage 7-9  (665) white prepupae new  (613) white prepupae 12hr  (389) white prepupae 24hr  (482) pupae 2d postWPP  (386) pupae 3d postWPP  (283) pupae 4d postWPP  (207) adult male 01day  (281) adult male 05day  (306) adult male 30day  (236) adult female 01day  (611) adult female 05day  (976) adult female 30day  (989) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (914) embryo 02-04hr  (229) embryo 04-06hr  (210) embryo 06-08hr  (388) embryo 08-10hr  (461) embryo 10-12hr  (519) embryo 12-14hr  (335) embryo 14-16hr  (238) embryo 16-18hr  (220) embryo 18-20hr  (178) embryo 20-22hr  (190) embryo 22-24hr  (180) larva L1  (406) larva L2  (623) larva L3 12hr old  (562) larva L3 puffstage 1-2  (499) larva L3 puffstage 3-6  (552) larva L3 puffstage 7-9  (665) white prepupae new  (613) white prepupae 12hr  (389) white prepupae 24hr  (482) pupae 2d postWPP  (386) pupae 3d postWPP  (283) pupae 4d postWPP  (207) adult male 01day  (281) adult male 05day  (306) adult male 30day  (236) adult female 01day  (611) adult female 05day  (976) adult female 30day  (989) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    914 embryo 02-04hr    229 embryo 04-06hr    210 embryo 06-08hr    388 embryo 08-10hr    461 embryo 10-12hr    519 embryo 12-14hr    335 embryo 14-16hr    238 embryo 16-18hr    220 embryo 18-20hr    178 embryo 20-22hr    190 embryo 22-24hr    180 larva L1    406 larva L2    623 larva L3 12hr old    562 larva L3 puffstage 1-2    499 larva L3 puffstage 3-6    552 larva L3 puffstage 7-9    665 white prepupae new    613 white prepupae 12hr    389 white prepupae 24hr    482 pupae 2d postWPP    386 pupae 3d postWPP    283 pupae 4d postWPP    207 adult male 01day    281 adult male 05day    306 adult male 30day    236 adult female 01day    611 adult female 05day    976 adult female 30day    989 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    353 Schneider line 2 Sg4    698 embryonic 1182-4H    348 embryonic GM2    505 embryonic Kc167    212 embryonic S1    412 embryonic S3    366 leg disc CME L1    533 wing disc CME-W2    566 wing disc ML-DmD8    517 wing disc ML-DmD9    346 wing disc ML-DmD16-c3    353 wing disc ML-DmD21    579 wing disc ML-DmD32    419 haltere disc ML-DmD17-c3    373 eye-antennal disc ML-DmD11    557 antennal disc ML-DmD20-c5    667 mixed discs ML-DmD4-c1    496 CNS ML-DmBG1-c1    407 CNS ML-DmBG2-c2    439 tumorous blood cells mbn2    336 ovary fGS/OSS    141 ovary OSC    81 ovary OSS    80 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (353) Schneider line 2 Sg4  (698) embryonic 1182-4H  (348) embryonic GM2  (505) embryonic Kc167  (212) embryonic S1  (412) embryonic S3  (366) leg disc CME L1  (533) wing disc CME-W2  (566) wing disc ML-DmD8  (517) wing disc ML-DmD9  (346) wing disc ML-DmD16-c3  (353) wing disc ML-DmD21  (579) wing disc ML-DmD32  (419) haltere disc ML-DmD17-c3  (373) eye-antennal disc ML-DmD11  (557) antennal disc ML-DmD20-c5  (667) mixed discs ML-DmD4-c1  (496) CNS ML-DmBG1-c1  (407) CNS ML-DmBG2-c2  (439) tumorous blood cells mbn2  (336) ovary fGS/OSS  (141) ovary OSC  (81) ovary OSS  (80) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (353) Schneider line 2 Sg4  (698) embryonic 1182-4H  (348) embryonic GM2  (505) embryonic Kc167  (212) embryonic S1  (412) embryonic S3  (366) leg disc CME L1  (533) wing disc CME-W2  (566) wing disc ML-DmD8  (517) wing disc ML-DmD9  (346) wing disc ML-DmD16-c3  (353) wing disc ML-DmD21  (579) wing disc ML-DmD32  (419) haltere disc ML-DmD17-c3  (373) eye-antennal disc ML-DmD11  (557) antennal disc ML-DmD20-c5  (667) mixed discs ML-DmD4-c1  (496) CNS ML-DmBG1-c1  (407) CNS ML-DmBG2-c2  (439) tumorous blood cells mbn2  (336) ovary fGS/OSS  (141) ovary OSC    81 ovary OSS    80 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    353 Schneider line 2 Sg4    698 embryonic 1182-4H    348 embryonic GM2    505 embryonic Kc167    212 embryonic S1    412 embryonic S3    366 leg disc CME L1    533 wing disc CME-W2    566 wing disc ML-DmD8    517 wing disc ML-DmD9    346 wing disc ML-DmD16-c3    353 wing disc ML-DmD21    579 wing disc ML-DmD32    419 haltere disc ML-DmD17-c3    373 eye-antennal disc ML-DmD11    557 antennal disc ML-DmD20-c5    667 mixed discs ML-DmD4-c1    496 CNS ML-DmBG1-c1    407 CNS ML-DmBG2-c2    439 tumorous blood cells mbn2    336 ovary fGS/OSS    141 ovary OSC    81 ovary OSS    80 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    353 Schneider line 2 Sg4    698 embryonic 1182-4H    348 embryonic GM2    505 embryonic Kc167    212 embryonic S1    412 embryonic S3    366 leg disc CME L1    533 wing disc CME-W2    566 wing disc ML-DmD8    517 wing disc ML-DmD9    346 wing disc ML-DmD16-c3    353 wing disc ML-DmD21    579 wing disc ML-DmD32    419 haltere disc ML-DmD17-c3    373 eye-antennal disc ML-DmD11    557 antennal disc ML-DmD20-c5    667 mixed discs ML-DmD4-c1    496 CNS ML-DmBG1-c1    407 CNS ML-DmBG2-c2    439 tumorous blood cells mbn2    336 ovary fGS/OSS    141 ovary OSC    81 ovary OSS    80 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (353) Schneider line 2 Sg4  (698) embryonic 1182-4H  (348) embryonic GM2  (505) embryonic Kc167  (212) embryonic S1  (412) embryonic S3  (366) leg disc CME L1  (533) wing disc CME-W2  (566) wing disc ML-DmD8  (517) wing disc ML-DmD9  (346) wing disc ML-DmD16-c3  (353) wing disc ML-DmD21  (579) wing disc ML-DmD32  (419) haltere disc ML-DmD17-c3  (373) eye-antennal disc ML-DmD11  (557) antennal disc ML-DmD20-c5  (667) mixed discs ML-DmD4-c1  (496) CNS ML-DmBG1-c1  (407) CNS ML-DmBG2-c2  (439) tumorous blood cells mbn2  (336) ovary fGS/OSS  (141) ovary OSC  (81) ovary OSS  (80) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (353) Schneider line 2 Sg4  (698) embryonic 1182-4H  (348) embryonic GM2  (505) embryonic Kc167  (212) embryonic S1  (412) embryonic S3  (366) leg disc CME L1  (533) wing disc CME-W2  (566) wing disc ML-DmD8  (517) wing disc ML-DmD9  (346) wing disc ML-DmD16-c3  (353) wing disc ML-DmD21  (579) wing disc ML-DmD32  (419) haltere disc ML-DmD17-c3  (373) eye-antennal disc ML-DmD11  (557) antennal disc ML-DmD20-c5  (667) mixed discs ML-DmD4-c1  (496) CNS ML-DmBG1-c1  (407) CNS ML-DmBG2-c2  (439) tumorous blood cells mbn2  (336) ovary fGS/OSS  141 ovary OSC    81 ovary OSS    80 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    353 Schneider line 2 Sg4    698 embryonic 1182-4H    348 embryonic GM2    505 embryonic Kc167    212 embryonic S1    412 embryonic S3    366 leg disc CME L1    533 wing disc CME-W2    566 wing disc ML-DmD8    517 wing disc ML-DmD9    346 wing disc ML-DmD16-c3    353 wing disc ML-DmD21    579 wing disc ML-DmD32    419 haltere disc ML-DmD17-c3    373 eye-antennal disc ML-DmD11    557 antennal disc ML-DmD20-c5    667 mixed discs ML-DmD4-c1    496 CNS ML-DmBG1-c1    407 CNS ML-DmBG2-c2    439 tumorous blood cells mbn2    336 ovary fGS/OSS    141 ovary OSC    81 ovary OSS    80 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    147 cold shock, 4-day adult    104 heat shock, 4-day adult    324 Cadmium 50 mM 6 hrs, larvae L3    412 Cadmium 50 mM 12 hrs, larvae L3    448 Cadmium 50 mM 48 hrs, 4-day adult    282 Cadmium 100 mM 48 hrs, 4-day adult    267 Copper 0.5 mM 12 hrs, larvae L3    163 Copper 15 mM 48 hrs, 4-day adult    173 Zinc 5 mM 12 hrs, larvae L3    146 Zinc 4.5 mM 48 hrs, 4-day adult    114 Ethanol 2.5% 3 hrs, larvae L3    426 Ethanol 5% 3 hrs, larvae L3    371 Ethanol 10% 3 hrs, larvae L3    334 Caffeine 1.5 mg/ml 4 hrs, larvae L3    286 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    322 Caffeine 25 mg/ml 48 hrs, 4-day adult    129 Paraquat 5 mM 48 hrs, 4-day adult    315 Paraquat 10 mM 48 hrs, 4-day adult    280 Rotenone 2 μg 12 hrs, larvae L3    450 Rotenone 8 μg 12 hrs, larvae L3    454 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (147) cold shock, 4-day adult  (104) heat shock, 4-day adult  (324) Cadmium 50 mM 6 hrs, larvae L3  (412) Cadmium 50 mM 12 hrs, larvae L3  (448) Cadmium 50 mM 48 hrs, 4-day adult  (282) Cadmium 100 mM 48 hrs, 4-day adult  (267) Copper 0.5 mM 12 hrs, larvae L3  (163) Copper 15 mM 48 hrs, 4-day adult  (173) Zinc 5 mM 12 hrs, larvae L3  (146) Zinc 4.5 mM 48 hrs, 4-day adult  (114) Ethanol 2.5% 3 hrs, larvae L3  (426) Ethanol 5% 3 hrs, larvae L3  (371) Ethanol 10% 3 hrs, larvae L3  (334) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (286) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (322) Caffeine 25 mg/ml 48 hrs, 4-day adult  (129) Paraquat 5 mM 48 hrs, 4-day adult  (315) Paraquat 10 mM 48 hrs, 4-day adult  (280) Rotenone 2 μg 12 hrs, larvae L3  (450) Rotenone 8 μg 12 hrs, larvae L3  (454) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (147) cold shock, 4-day adult  104 heat shock, 4-day adult  (324) Cadmium 50 mM 6 hrs, larvae L3  (412) Cadmium 50 mM 12 hrs, larvae L3  (448) Cadmium 50 mM 48 hrs, 4-day adult  (282) Cadmium 100 mM 48 hrs, 4-day adult  (267) Copper 0.5 mM 12 hrs, larvae L3  (163) Copper 15 mM 48 hrs, 4-day adult  (173) Zinc 5 mM 12 hrs, larvae L3  (146) Zinc 4.5 mM 48 hrs, 4-day adult  (114) Ethanol 2.5% 3 hrs, larvae L3  (426) Ethanol 5% 3 hrs, larvae L3  (371) Ethanol 10% 3 hrs, larvae L3  (334) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (286) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (322) Caffeine 25 mg/ml 48 hrs, 4-day adult  (129) Paraquat 5 mM 48 hrs, 4-day adult  (315) Paraquat 10 mM 48 hrs, 4-day adult  (280) Rotenone 2 μg 12 hrs, larvae L3  (450) Rotenone 8 μg 12 hrs, larvae L3  (454) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    147 cold shock, 4-day adult    104 heat shock, 4-day adult    324 Cadmium 50 mM 6 hrs, larvae L3    412 Cadmium 50 mM 12 hrs, larvae L3    448 Cadmium 50 mM 48 hrs, 4-day adult    282 Cadmium 100 mM 48 hrs, 4-day adult    267 Copper 0.5 mM 12 hrs, larvae L3    163 Copper 15 mM 48 hrs, 4-day adult    173 Zinc 5 mM 12 hrs, larvae L3    146 Zinc 4.5 mM 48 hrs, 4-day adult    114 Ethanol 2.5% 3 hrs, larvae L3    426 Ethanol 5% 3 hrs, larvae L3    371 Ethanol 10% 3 hrs, larvae L3    334 Caffeine 1.5 mg/ml 4 hrs, larvae L3    286 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    322 Caffeine 25 mg/ml 48 hrs, 4-day adult    129 Paraquat 5 mM 48 hrs, 4-day adult    315 Paraquat 10 mM 48 hrs, 4-day adult    280 Rotenone 2 μg 12 hrs, larvae L3    450 Rotenone 8 μg 12 hrs, larvae L3    454 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    147 cold shock, 4-day adult    104 heat shock, 4-day adult    324 Cadmium 50 mM 6 hrs, larvae L3    412 Cadmium 50 mM 12 hrs, larvae L3    448 Cadmium 50 mM 48 hrs, 4-day adult    282 Cadmium 100 mM 48 hrs, 4-day adult    267 Copper 0.5 mM 12 hrs, larvae L3    163 Copper 15 mM 48 hrs, 4-day adult    173 Zinc 5 mM 12 hrs, larvae L3    146 Zinc 4.5 mM 48 hrs, 4-day adult    114 Ethanol 2.5% 3 hrs, larvae L3    426 Ethanol 5% 3 hrs, larvae L3    371 Ethanol 10% 3 hrs, larvae L3    334 Caffeine 1.5 mg/ml 4 hrs, larvae L3    286 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    322 Caffeine 25 mg/ml 48 hrs, 4-day adult    129 Paraquat 5 mM 48 hrs, 4-day adult    315 Paraquat 10 mM 48 hrs, 4-day adult    280 Rotenone 2 μg 12 hrs, larvae L3    450 Rotenone 8 μg 12 hrs, larvae L3    454 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (147) cold shock, 4-day adult  (104) heat shock, 4-day adult  (324) Cadmium 50 mM 6 hrs, larvae L3  (412) Cadmium 50 mM 12 hrs, larvae L3  (448) Cadmium 50 mM 48 hrs, 4-day adult  (282) Cadmium 100 mM 48 hrs, 4-day adult  (267) Copper 0.5 mM 12 hrs, larvae L3  (163) Copper 15 mM 48 hrs, 4-day adult  (173) Zinc 5 mM 12 hrs, larvae L3  (146) Zinc 4.5 mM 48 hrs, 4-day adult  (114) Ethanol 2.5% 3 hrs, larvae L3  (426) Ethanol 5% 3 hrs, larvae L3  (371) Ethanol 10% 3 hrs, larvae L3  (334) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (286) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (322) Caffeine 25 mg/ml 48 hrs, 4-day adult  (129) Paraquat 5 mM 48 hrs, 4-day adult  (315) Paraquat 10 mM 48 hrs, 4-day adult  (280) Rotenone 2 μg 12 hrs, larvae L3  (450) Rotenone 8 μg 12 hrs, larvae L3  (454) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (147) cold shock, 4-day adult  104 heat shock, 4-day adult  (324) Cadmium 50 mM 6 hrs, larvae L3  (412) Cadmium 50 mM 12 hrs, larvae L3  (448) Cadmium 50 mM 48 hrs, 4-day adult  (282) Cadmium 100 mM 48 hrs, 4-day adult  (267) Copper 0.5 mM 12 hrs, larvae L3  (163) Copper 15 mM 48 hrs, 4-day adult  (173) Zinc 5 mM 12 hrs, larvae L3  (146) Zinc 4.5 mM 48 hrs, 4-day adult  114 Ethanol 2.5% 3 hrs, larvae L3  (426) Ethanol 5% 3 hrs, larvae L3  (371) Ethanol 10% 3 hrs, larvae L3  (334) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (286) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (322) Caffeine 25 mg/ml 48 hrs, 4-day adult  129 Paraquat 5 mM 48 hrs, 4-day adult  (315) Paraquat 10 mM 48 hrs, 4-day adult  (280) Rotenone 2 μg 12 hrs, larvae L3  (450) Rotenone 8 μg 12 hrs, larvae L3  (454) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    147 cold shock, 4-day adult    104 heat shock, 4-day adult    324 Cadmium 50 mM 6 hrs, larvae L3    412 Cadmium 50 mM 12 hrs, larvae L3    448 Cadmium 50 mM 48 hrs, 4-day adult    282 Cadmium 100 mM 48 hrs, 4-day adult    267 Copper 0.5 mM 12 hrs, larvae L3    163 Copper 15 mM 48 hrs, 4-day adult    173 Zinc 5 mM 12 hrs, larvae L3    146 Zinc 4.5 mM 48 hrs, 4-day adult    114 Ethanol 2.5% 3 hrs, larvae L3    426 Ethanol 5% 3 hrs, larvae L3    371 Ethanol 10% 3 hrs, larvae L3    334 Caffeine 1.5 mg/ml 4 hrs, larvae L3    286 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    322 Caffeine 25 mg/ml 48 hrs, 4-day adult    129 Paraquat 5 mM 48 hrs, 4-day adult    315 Paraquat 10 mM 48 hrs, 4-day adult    280 Rotenone 2 μg 12 hrs, larvae L3    450 Rotenone 8 μg 12 hrs, larvae L3    454 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_02 mE1_20_mRNA_expression_cluster_10
External Data & Images
Linkouts	BDGP expression data • SD01793 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004432 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9916-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Cyp1 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive Cyp1317 viable, with Scer\GAL4pnr-MD237 Cyp1GD4174 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 Cyp1GD4174 Phenotype manifest in Allele trichogen cell, with Scer\GAL4pnr-MD237 Cyp1GD4174
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of Cyp1 Class Mutagen Stocks Known lesion Cyp1EP1073 P-element activity 1 -- Cyp1NP0066 1 -- Cyp1317 ethyl methanesulfonate 0 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Cyp1 Class Mutagen Stocks Known lesion Cyp1GD4174 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Cyp1HMS00801 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Cyp1HMS00902 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Cyp1KK107728 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Cyp1NIG.9916R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)4b18 (Rutherford, 1995) Df(1)19 (Rutherford, 1995) Df(1)l32 (Rutherford, 1995) Dp(1;4)exd81h24b (Rutherford, 1995)
Not disrupted in	Df(1)E150 (Rutherford, 1995) Df(1)sd72b (Rutherford, 1995) Dp(1;4)81j23a (Rutherford, 1995)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4174} NA P{KK107728} NA P{NIG.9916R} NA P{TRiP.HMS00801} NA P{TRiP.HMS00902} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Cyp1EP1073 NA insertion of enhancer trap binary system P{GawB}Cyp1NP0066 No
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
autophagic cell death inferred from expression pattern (Gorski et al., 2003) salivary gland cell autophagic cell death inferred from expression pattern (Gorski et al., 2003)
Cellular Component
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
cyclin-dependent protein serine/threonine kinase regulator activity non-traceable author statement (Swiss-Prot Project Members, 2000.10.1) peptidyl-prolyl cis-trans isomerase activity inferred from electronic annotation with InterPro:IPR002130, InterPro:IPR020892 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Stamnes et al., 1991) non-traceable author statement (Swiss-Prot Project Members, 1992.3.1)
Biological Process
CV term Evidence References
protein folding inferred from electronic annotation with InterPro:IPR002130, InterPro:IPR020892 (FlyBase Curators et al., 2004-) non-traceable author statement (Swiss-Prot Project Members, 1992.3.1)
Cellular Component
CV term Evidence References
cytoplasm non-traceable author statement (Swiss-Prot Project Members, 1992.3.1) cytosol inferred from sequence or structural similarity (Stamnes et al., 1991) nuclear cyclin-dependent protein kinase holoenzyme complex non-traceable author statement (Swiss-Prot Project Members, 2000.10.1) positive transcription elongation factor complex b non-traceable author statement (Swiss-Prot Project Members, 2000.10.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Cyp1 - AnxB10 experimental knowledge based (Guruharsha et al., 2011) Cyp1 - CG42557 experimental knowledge based (Guruharsha et al., 2011) Cyp1 - CG4570 experimental knowledge based (Guruharsha et al., 2011) Cyp1 - Chd64 experimental knowledge based (Guruharsha et al., 2011) Cyp1 - Crc experimental knowledge based (Guruharsha et al., 2011) Cyp1 - Df31 experimental knowledge based (Guruharsha et al., 2011) Cyp1 - Eno experimental knowledge based (Guruharsha et al., 2011) Cyp1 - FK506-bp2 experimental knowledge based (Guruharsha et al., 2011) Cyp1 - Nlp experimental knowledge based (Guruharsha et al., 2011) Cyp1 - Ntf-2 experimental knowledge based (Guruharsha et al., 2011) Cyp1 - Sh3β experimental knowledge based (Guruharsha et al., 2011) Cyp1 - Sod experimental knowledge based (Guruharsha et al., 2011) Cyp1 - Tango2 experimental knowledge based (Guruharsha et al., 2011) Cyp1 - Trx-2 experimental knowledge based (Guruharsha et al., 2011) Cyp1 - awd experimental knowledge based (Guruharsha et al., 2011) Cyp1 - fabp experimental knowledge based (Guruharsha et al., 2011) Cyp1 - regucalcin experimental knowledge based (Guruharsha et al., 2011) Cyp1 - smt3 experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Cyp1 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58935 DroID - A comprehensive database of gene and protein interactions. • FBgn0004432 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32595
Orthologs
OrthoDB Orthologs (124) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6W0Z0C Dipteran inclusive ortholog search EOG6H1B51 Insect inclusive ortholog search EOG6HT7PD Arthropod inclusive ortholog search EOG61RNB3 Metazoa inclusive ortholog search EOG651SJN
Orthologs in Drosophila Species (EOG6W0Z0C)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Cyp1     Drosophila simulans   Dsim\GD20227 Y   Drosophila sechellia   Dsec\GM13410 Y   Drosophila erecta   Dere\GG19332 Y   Drosophila yakuba   Dyak\Cyp1 Y   Drosophila ananassae   Dana\GF19040 Y   Drosophila pseudoobscura pseudoobscura   Dpse\Cyp1 Y   Drosophila willistoni   Dwil\GK16511 Y   Drosophila virilis   Dvir\GJ19133 Y   Drosophila mojavensis   Dmoj\GI21755 Y   Drosophila grimshawi   Dgri\GH17842 Y   Drosophila grimshawi   Dgri\GH10794
Orthologs in non-Drosophila Dipterans (EOG6H1B51)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL011758 Y Anopheles gambiae Malaria mosquito  Agam\AGAP000462 Y
Orthologs in non-Dipteran Insects (EOG6HT7PD)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC409890 Y Apis mellifera Western honey bee  Amel\LOC724326 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG010578 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG000319 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH18668 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14591 Y Atta cephalotes Leafcutter ant  Acep\ACEP19070 Y Atta cephalotes Leafcutter ant  Acep\ACEP21141 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO17716 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO12427 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17635 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL11080 Y Linepithema humile Argentine ant  Lhum\LH21594 Y Linepithema humile Argentine ant  Lhum\LH15881 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB11047 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB23763 Y Solenopsis invicta Red fire ant  Sinv\SINV21642 Y Solenopsis invicta Red fire ant  Sinv\SINV11667 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI003541 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI001656 Y Bombyx mori Silkmoth  Bmor\BGIBMGA003522 Y Bombyx mori Silkmoth  Bmor\BGIBMGA002429 Y Pediculus humanus Human body louse  Phum\PHUM221330 Y Tribolium castaneum Red flour beetle  Tcas\TC004820 Y
Orthologs in non-Insect Arthropods (EOG61RNB3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_92663 Y Ixodes scapularis Deer tick  Isca\ISCW021667 Y Ixodes scapularis Deer tick  Isca\ISCW008497 Y
Orthologs in non-Arthropod Metazoa (EOG651SJN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\cyn-9 Y Caenorhabditis elegans Nematode  Cele\cyn-11 Y Caenorhabditis elegans Nematode  Cele\cyn-1 Y Caenorhabditis elegans Nematode  Cele\cyn-2 Y Caenorhabditis elegans Nematode  Cele\cyn-13 Y Caenorhabditis elegans Nematode  Cele\cyn-3 Y Caenorhabditis elegans Nematode  Cele\cyn-7 Y Caenorhabditis elegans Nematode  Cele\cyn-8 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003109gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002789gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_028896gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015311gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015986gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000637gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002790gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_022735gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008305gn Y Danio rerio Zebrafish  Drer\ppial Y Danio rerio Zebrafish  Drer\ppif Y Danio rerio Zebrafish  Drer\ppil6 Y Danio rerio Zebrafish  Drer\zgc:123307 Y Danio rerio Zebrafish  Drer\ppig Y Danio rerio Zebrafish  Drer\nktr Y Danio rerio Zebrafish  Drer\ppih Y Danio rerio Zebrafish  Drer\ppia Y Danio rerio Zebrafish  Drer\ppie Y Danio rerio Zebrafish  Drer\ENSDARG00000087128 Y Xenopus tropicalis Western clawed frog  Xtro\ppie Y Xenopus tropicalis Western clawed frog  Xtro\ppia Y Xenopus tropicalis Western clawed frog  Xtro\ppil6 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000025399 Y Xenopus tropicalis Western clawed frog  Xtro\nktr Y Xenopus tropicalis Western clawed frog  Xtro\ppih Y Xenopus tropicalis Western clawed frog  Xtro\ppid Y Gallus gallus Domestic chicken  Ggal\PPIH Y Gallus gallus Domestic chicken  Ggal\PPIL6 Y Gallus gallus Domestic chicken  Ggal\PPIF Y Gallus gallus Domestic chicken  Ggal\PPIE Y Gallus gallus Domestic chicken  Ggal\PPID Y Gallus gallus Domestic chicken  Ggal\NKTR Y Gallus gallus Domestic chicken  Ggal\PPIG Y Mus musculus House mouse  Mmus\Ppil6 Y Mus musculus House mouse  Mmus\Ppif Y Mus musculus House mouse  Mmus\Gm9234 Y Mus musculus House mouse  Mmus\Ppia Y Mus musculus House mouse  Mmus\Nktr Y Mus musculus House mouse  Mmus\Ppig Y Mus musculus House mouse  Mmus\Gm5160 Y Mus musculus House mouse  Mmus\ENSMUSG00000091052 Y Mus musculus House mouse  Mmus\Ppia Y Mus musculus House mouse  Mmus\Ppie Y Mus musculus House mouse  Mmus\Ppid Y Mus musculus House mouse  Mmus\Ppih Y Rattus norvegicus Norway rat  Rnor\Ppia Y Rattus norvegicus Norway rat  Rnor\Ppig Y Rattus norvegicus Norway rat  Rnor\Ppie Y Rattus norvegicus Norway rat  Rnor\Ppia Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000030050 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000036609 Y Rattus norvegicus Norway rat  Rnor\Ppif Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000023821 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000008489 Y Rattus norvegicus Norway rat  Rnor\Ppid Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000023461 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000027085 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000024916 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000039269 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000002712 Y Rattus norvegicus Norway rat  Rnor\Ppil6 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000031045 Y Homo sapiens Human  Hsap\PPID Y Homo sapiens Human  Hsap\ENSG00000185250 Y Homo sapiens Human  Hsap\ENSG00000255963 Y Homo sapiens Human  Hsap\ENSG00000255854 Y Homo sapiens Human  Hsap\ENSG00000198161 Y Homo sapiens Human  Hsap\NKTR Y Homo sapiens Human  Hsap\PPIE Y Homo sapiens Human  Hsap\PPIAL4D Y Homo sapiens Human  Hsap\PPIH Y Homo sapiens Human  Hsap\PPIA Y Homo sapiens Human  Hsap\PPIF Y Homo sapiens Human  Hsap\PPIAL4G Y Homo sapiens Human  Hsap\PPIG Y
Human Orthologs (13)
Gene OMIM HGNC Hsap\PPID     Hsap\ENSG00000185250     Hsap\ENSG00000255963     Hsap\ENSG00000255854     Hsap\ENSG00000198161     Hsap\NKTR     Hsap\PPIE     Hsap\PPIAL4D     Hsap\PPIH     Hsap\PPIA     Hsap\PPIF     Hsap\PPIAL4G     Hsap\PPIG
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD20227 Drosophila sechellia Dsec\GM13410 Drosophila erecta Dere\GG19332 Drosophila yakuba Dyak\Cyp1 Drosophila ananassae Dana\GF19040 Drosophila pseudoobscura pseudoobscura Dpse\Cyp1 Drosophila willistoni Dwil\GK16511 Drosophila virilis Dvir\GJ19133 Drosophila mojavensis Dmoj\GI21755 Drosophila grimshawi Dgri\GH17842
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	10136 w1118 P{EP}Cyp1EP1073 33001 y1 sc* v1; P{TRiP.HMS00801}attP2 33950 y1 sc* v1; P{TRiP.HMS00902}attP2
Kyoto	112028 w* P{GawB}Cyp1NP0066 / FM7c
VDRC	v104005 P{KK107728}VIE-260B v41015 w1118; P{GD4174}v41015
Genomic Clones ( 2 )
	BACR06P10 BACR13G13 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 321 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM09255 RE62690 SD01793
Other clones	yak-ad_Cyp1 yak-em_Cyp1
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT17656 GH01024 GH10854 GH19954 GH22815 GH26809 GM02364 GM06328 GM07721 GM09432 GM10985 GM13034 GM23288 GM26019 GM27791 GM28183 GM30506 GM32702 LD15824 LD18401 LD26947 LP03370 LP04479 LP11867 LP16307 LP16852 RE05105 RE05923 RE05941 RE08246 RE10086 RE14243 RE17037 RE17085 RE19173 RE19341 RE20425 RE21746 RE21801 RE23572 RE24966 RE24972 RE25927 RE26828 RE29492 RE30926 RE32677 RE34675 RE36947 RE39046 RE40593 RE41296 RE48909 RE50048 RE50809 RE57377 RE60346 RE60389 RE61115 RE63834 RE65326 RE65457 RE67233 RE67752 RE68814 RE69373 RE71943 RE73106 RE73230 RE74092 RH04665 RH07416 RH11867 RH14034 RH14129 RH17837 RH17989 RH22804 RH23150 RH24736 RH25503 RH26927 RH27082 RH27193 RH27201 RH27632 RH36015 RH36281 RH36491 RH37236 RH39976 RH41920 RH42659 RH46623 RH47027 RH48356 RH52689 RH53901 RH54744 RH57146 RH57925 RH58417 RH60026 RH60788 RH61829 RH62703 RH63226 RH69953 RH70401 RH71781 RH71993 RH73994 SD03265 SD15582 SD17596 SD21509 SD22379 SD23296 SD24061 SD24539
Other clones	8209 11621 41648 45446 58175 77672 77919 81506 82598 106525 108487 108495 156287 165807 214245.40 214449.40 240902 522888 523673 523940 525431 525677 527270 542802 542875 561828 568976 569681 bs01c04 bs50c12 CK01.20A.B2 CK01.44B.F1 CK01.44C.E11 CK01.56B.G8 CK01.63A.H3 CK01.77D.G5 CK01.86A.F11 CK01.107A.D2 CK01.120D.H11 CK01.129A.G3 Dmel_dig_000102_0673_0282 Dmel_dig_000263_0683_3368 Dmel_dig_001552_0603_0395 Dmel_dig_002406_0683_2308 Dmel_dig_003686_0690_3618 Dmel_dig_004165_0651_1814 Dmel_dig_004362_0696_3560 Dmel_dig_004545_0704_1357 Dmel_dig_005434_0715_1842 Dmel_dig_006550_0709_2233 Dmel_dig_007229_0608_0389 Dmel_dig_009111_0597_1824 Dmel_dig_010495_0658_1667 Dmel_dig_010826_0623_1464 Dmel_dig_010887_0652_0330 Dmel_dig_010992_0628_1047 Dmel_dig_011331_0704_0828 Dmel_dig_011539_0707_3500 Dmel_dig_012112_0649_1667 Dmel_dig_012722_0611_0672 Dmel_dig_012896_0601_2010 Dmel_dig_013008_0619_0921 Dmel_dig_013877_0651_3305 Dmel_dig_013983_0600_2340 Dmel_dig_014020_0692_2346 Dmel_dig_014547_0599_0620 Dmel_dig_016529_0642_0435 Dmel_dig_016667_0714_1910 Dmel_dig_017513_0699_1272 Dmel_dig_019039_0656_0432 Dmel_dig_019461_0612_3773 Dmel_dig_021063_0641_0449 Dmel_neb_000522_0368_0300 Dmel_neb_003308_0622_3673 Dmel_neb_005930_0081_3344 Dmel_neb_007037_0386_3583 Dmel_neb_008045_0840_1987 Dmel_neb_008308_0369_1744 Dmel_neb_008830_0925_2437 Dmel_neb_009123_0173_2723 Dmel_neb_009347_0402_1162 Dmel_neb_010147_0819_2535 Dmel_neb_010612_0180_1597 Dmel_neb_010718_0698_1994 Dmel_neb_011526_0687_1809 Dmel_neb_011553_0841_1672 Dmel_neb_011726_0572_3544 Dmel_neb_012388_0579_2010 Dmel_neb_012781_0190_2751 Dmel_neb_013121_0874_1246 Dmel_neb_013230_0820_2008 Dmel_neb_013310_0895_1636 Dmel_neb_013436_0887_0542 Dmel_neb_013454_0828_2372 Dmel_neb_013514_0142_0386 Dmel_neb_013669_0890_2659 Dmel_neb_013943_0639_3296 Dmel_neb_014281_0671_3215 Dmel_neb_014763_0899_0473 Dmel_neb_014895_0409_2873 Dmel_neb_015325_0688_0415 Dmel_neb_015429_0313_3092 Dmel_neb_015832_0698_2949 Dmel_neb_016373_0904_1100 EC13124 EC14391 EC15143 EC32171 EC32519 EC34588 EC35031 EC39232 EC40251 EK018728 EK037720 EK045560 EK050955 EK054529 EK060627 EK067924 EK089345 EK092530 EK095520 EK106738 EK112645 EK127004 EK161032 EK179522 EK210939 EK211616 EK232019 EK258860 EK270250 EN00408 EN02955 EN04454 EN06928 EN11349 EN11529 EN15362 EP12132 EP12228 ESG012d.E21_G05 ESG013a.E21.1_D09 FGA004C09 FGC013A12 FGC015H12 FGC026F07 FGC026F11 FGC030D11 FGC032H04 FGH101G02 FGH107F07 FGH110C08 FGH114E08 FGM206G05 FGM207E08 FGM213G03 FGM217F12 FGM220E05 FGM221B04 FGM222A05 FGM228D01 FGM229E12 FGM230E03 FGM235A01 FGM237A12 FGM312F09 FGM313D01 FGM315D08 FGM319D04 FGM321C07 FGM321C12 GH02824 GH22403 IP13754 IP17689 RC0-DA0003-130700-011-A02 RE01406 RE01793 RE01887 RE12233 RE18735 RE40368 RH04650 RH04671 RH09387 RH10325 RH13512 RH16712 RH36008 RH39634 RH45344 RH55127 RH62325 UUGC0558
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004432 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32595
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Cyp1 BcDNA:GM09255 (FlyBase, 1996-)
Additional comments	Source for merge of Cyp1 BcDNA:GM09255 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
	"Gene order: In direction of increasing cytology: Cyp1- nonA?" was stated as revision. (Rutherford, 1996.11.4) Identified in 2D gels of CMW W2 wing imaginal disc cell (spot NEPHGE/16). (Santaren et al., 1993) Cyp1 is expressed throughout development and produces two alternatively processed forms. (Stamnes et al., 1991)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078642 RefSeq (Proteins) • NP_523366 DDBJ / EMBL / GenBank • AA697172 AAB03701 AAF48589 AAL28510 AAQ22415 AI297544 AI530979 AI944424 AQ025378 AW941965 AW944203 AY060962 BT009946 M62398 Z32274 Entrez Gene - A searchable database of RefSeq genes. • 32595 UniProtKB/Swiss-Prot • P25007 UniProtKB/TrEMBL • Q95S46
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Cyclophilin-like peptidyl-prolyl cis-trans isomerase domain (IPR002130) Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site (IPR020892) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • SD01793
Linkouts
	BioGRID - A database of protein and genetic interactions • 58935 DroID - A comprehensive database of gene and protein interactions. • FBgn0004432 DRSC - Results from RNAi screens. • FBgn0004432 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004432 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9916-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004432 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32595 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32595 modMine - Data generated by the modENCODE project. • FBgn0004432
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	BcDNA:GM09255   CG9916 (Keleman et al., 2009.8.5, Hughes et al., 2008, Ni et al., 2010.12.1, Ling and Salvaterra, 2011, Cammarato et al., 2011) Cpy1 (Dunn et al., 2001, Comeron and Kreitman, 1998) cyp-1 (Stamnes, 1996.7.12) CyP-1 (Stamnes et al., 1992) Cyp-1 (Rutherford, 1996.11.4, Rutherford, 1995) cyp1 (Bartolome and Charlesworth, 2006) Cyp1 (Legube et al., 2006, Langille and Clark, 2007, Kallappagoudar et al., 2010, Birch-Machin et al., 2005, Ling and Salvaterra, 2011, Seong et al., 2011, Franco et al., 2011, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym	Cyclophilin 1 (Cammarato et al., 2011, Fisher et al., 2008) cyclophilin1 (Birch-Machin et al., 2005) Peptidyl-prolyl cis-trans isomerase (Pflieger et al., 2008) Peptidylprolyl isomerase F (Ling and Salvaterra, 2011)
Secondary FlyBase IDs
	FBgn0047257
References ( 55 )
Generate a list of	All references relating to this gene ( 55 )
List References by type	Research paper  ( 25 ) Supplementary material  ( 7 ) Review  ( 1 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 2 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Thesis  ( 1 ) Stock list  ( 1 ) Protein sequence record  ( 2 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 5 )
	Díaz-Castillo and Ranz, 2012, Mol. Biol. Evol. 29(9): 2105--2108 Nuclear chromosome dynamics in the Drosophila male germ line contribute to the nonrandom genomic distribution of retrogenes. [FBrf0219274] Franco et al., 2011, Mol. Cell. Proteomics 10(5): M110.002188 A Novel Strategy to Isolate Ubiquitin Conjugates Reveals Wide Role for Ubiquitination during Neural Development. [FBrf0213919] Ling and Salvaterra, 2011, PLoS ONE 6(3): e17762 Robust RT-qPCR Data Normalization: Validation and Selection of Internal Reference Genes during Post-Experimental Data Analysis. [FBrf0213272] Morozova et al., 2011, Genetics 187(4): 1193--1205 Transcriptional networks for alcohol sensitivity in Drosophila melanogaster. [FBrf0214377] Seong et al., 2011, Biogerontology 12(2): 93--107 Genome-wide analysis of low-dose irradiated male Drosophila melanogaster with extended longevity. [FBrf0213307] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...