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Gene Dmel\Gαq

General Information
Symbol	Dmel\Gαq	Species	D. melanogaster
Name	G protein α q subunit	Annotation symbol	CG17759
Feature type	protein_coding_gene	FlyBase ID	FBgn0004435
Gene Model Status	Current	Stock availability	20 publicly available
Also Known As	dgq, gα49B, Gαq, Gqα, Galpha49b, dGqα, Gq, Gq, Gα, Gαq
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	49B8-49B9	Sequence location	2R:8,500,245..8,510,702 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene G protein α q subunit is referred to in FlyBase by the symbol Dmel\Gαq (CG17759, FBgn0004435). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: GTPase activity. There is experimental evidence for 12 unique biological process terms, many of which group under: biological regulation; phototransduction; immune response; cellular response to oxygen-containing compound; cellular component organization or biogenesis; locomotory behavior; response to temperature stimulus; system process; flight behavior; response to organic substance; organ or tissue specific immune response; regulation of rhodopsin mediated signaling pathway; positive regulation of catalytic activity; cellular ion homeostasis; regulation of developmental process; phototransduction, visible light; sensory perception of chemical stimulus; single-organism developmental process. 33 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; organ system; antennal olfactory receptor neuron; adult segment; peripheral nervous system; embryonic/larval neuron; appendage segment; cell part; external compound sense organ; rhabdomere. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: G protein alpha subunit, helical insertion; G-protein alpha subunit, group Q; Guanine nucleotide binding protein (G-protein), alpha subunit. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, larval/adult fat body, larval/adult salivary gland, adult male accessory gland, larval carcass. Gene sequence location is 2R:8500245..8510702.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02	Controlled Vocabulary Terms extrinsic to internal side of plasma membrane phospholipase C-activating dopamine receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 49B8-49B9   Limits computationally determined from genome sequence between P{EP}AmphEP2175&P{lacW}spt4k05316 and P{PZ}ox1
Experimentally Determined Cytological Location
Cytogenetic map Notes References 49B-49B   (determined by in situ hybridisation)   (Lee et al., 1990)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Gαq for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Stage-specific extension of 3' UTRs observed during embryogenesis (FBrf0215804); all variants may not be annotated. 5' UTR contains an ORF described as a putative conserved uORF (FBrf0204849); potential peptide 31aa in length. Low-frequency RNA-Seq exon junction(s) not annotated. Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Annotated transcripts do not represent all supported alternative splices within 5' UTR. Gene model reviewed during 5.46 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Gαq-RA FBtr0087829  NM_165919   3050   353 Gαq-RC FBtr0087831  NM_165921   3660   353 Gαq-RD FBtr0087832  NM_165924   1615   353 Gαq-RE FBtr0087833  NM_165922   3509   353 Gαq-RJ FBtr0333101  NM_165920   1813   396 Gαq-RK FBtr0304955  NM_165925   5648   353
Additional Transcript Data & Comments
Reported size (kB)	3.549 (longest cDNA) (Talluri et al., 1995) 1.8 (northern blot) (Lee et al., 1990)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Gαq-PA   FBpp0086942   41.6   353   4.83     NP_725191   AAF58485 Gαq-PC   FBpp0086944   41.6   353   4.83     NP_725193   AAM68627 Gαq-PD   FBpp0086945   41.3   353   4.94     NP_725196   AAM68631 Gαq-PE   FBpp0086946   41.6   353   4.83     NP_725194   AAM68628 Gαq-PJ   FBpp0305314   46.4   396   4.64     NP_725192   AAG22276 Gαq-PK   FBpp0293494   41.6   353   4.83     NP_725197   AAM68632
Additional Polypeptide Data & Comments
Reported size (kDa)	353 (aa) (Talluri et al., 1995) 317 (aa); 41.3, 37.2 (kD predicted) (Lee et al., 1990)
Comments	Gβ76C protein, Gα49B protein, and Gγ30A protein are all expressed in the same pattern supporting the hypothesis that Gγ30A is part of a heterotrimeric eye-specific G protein. (Schulz et al., 1999)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • G-protein alpha subunit, group Q (IPR000654) Guanine nucleotide binding protein (G-protein), alpha subunit (IPR001019) G protein alpha subunit, helical insertion (IPR011025) P-loop containing nucleoside triphosphate hydrolase (IPR027417)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA263626   AA390697   AA391585   AA439352   AA539646   AA540016   AA567320   AA567439   AA694764   AA698016   AA698248   AA698851   AA801561   AA951538   AE013599 AAF58485   AE013599 AAG22276   AE013599 AAM68627   AE013599 AAM68628   AE013599 AAM68631   AE013599 AAM68632   AI113343   AI113889   AI517476   AI541831   AW941137   AW942291   AY118511 AAM49880   AY118609   BG637964   BH809573   BH809575   BI165578   BI165613   BI165623   BI168658   BI172267   BI230350   BI368591   BI372025   BI482157   BI484211   BI563787   BI563795   BI569098   BI569099   BI570099   BI570620   BI571023   BI571394   BI572191   BI573078   BI573109   BI586281   BI590256   BI591139   BI604616   BI605034   BI605038   BI605682   BI614347   BI616933   BI617178   BI621104   BI622556   BI623472   BI625969   BI627090   BI628345   BI629934   BI630323   BI631149   BP556840   BQ103607   BT011067   BT024269   CK086554   CO155693   CO177462   CO178322   CO179776   CO179820   CO180904   CO185710   CO186682   CO188258   CO189121   CO265723   CO266246   CO266458   CO267474   CO269630   CO270214   CO271327   CO271628   CO271822   CO271846   CO273335   CO273493   CO280017   CO282540   CO282939   CO284357   CO285757   CO288196   CO288953   CO288964   CO289160   CO289224   CO289313   CO292159   CO292648   CO293309   CO293954   CO294689   CO294779   CO295481   CO296272   CO296520   CO298857   CO301476   CO302029   CO302910   CO302912   CO303732   CO305857   CO305859   CO306732   CO307689   CO308227   CO309712   CO311802   CO312030   CO314202   CO314224   CO314670   CO315210   CO315239   CO315417   CO315984   CO318221   CO318629   CO321435   CO323453   CO324337   CO327254   CO327355   CO327359   CO327794   CO327845   CO327946   CO328321   CO328418   CO328619   CO330602   CO330877   CO331088   CO331125   CO332469   CO333466   CO333861   CO339822   CO340339   CO340560   CO340592   CO340608   CO344813   CZ486755   CZ486756   DN154192   DN154412   EC057898   EC060050   EC060133   EC063758   EC063827   EC065864   EC066005   EC066371   EC067504   EC067692   EC073016   EC076741   EC082386   EC083621   EC084506   EC085075   EC085704   EC086012   EC086093   EC086318   EC086808   EC086820   EC087201   EC087284   EC087732   EC088348   EC088714   EC089453   EC090492   EC201101   EC201722   EC203603   EC204381   EC205281   EC208446   EC212803   EC213311   EC213686   EC213778   EC214146   EC215977   EC218594   EC220161   EC221201   EC225781   EC226198   EC227216   EC228025   EC228326   EC230680   EC233531   EC233689   EC234496   EC235583   EC235692   EC238175   EC238434   EC239564   EC240471   EC242018   EC245094   EC246317   EC246705   EC246795   EC248074   EC248286   EC248859   EC249319   EC251937   EC252914   EC253017   EC253286   EC255146   EC255751   EC256953   EC257615   EC258101   EC258155   EC259147   EC260198   EC260344   EC263903   EL875335   EL884065   EL884177   EL884178   EV584966   GH291446   GH964149   M58016 AAA28460   U31092 AAC46943
UniProtKB/Swiss-Prot	P23625
UniProtKB/TrEMBL	A4UZE6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
expression microarray Stage Tissue/Position (including subcellular localization) Reference adult stage   eye   (Xu et al., 2004) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   head mesoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) central brain primordium   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   Bolwig organ   (Fisher et al., 2012) embryonic brain   (Fisher et al., 2012) embryonic foregut   (Fisher et al., 2012) embryonic head sensory system   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) embryonic stage 13 -- 17   presumptive embryonic/larval central nervous system   (Ratnaparkhi et al., 2002) embryonic stage 16 -- 17   Bolwig organ   (Ratnaparkhi et al., 2002) northern blot Stage Tissue/Position (including subcellular localization) Reference adult stage   retina   (Lee et al., 1990) adult head   (Lee et al., 1990) ocellus   (Lee et al., 1990) pcr Stage Tissue/Position (including subcellular localization) Reference adult stage   adult brain   (Alvarez et al., 1996) eye   (Alvarez et al., 1996) ocellus   (Alvarez et al., 1996)   (Alvarez et al., 1996) spermatogenesis & adult stage   testis   (Alvarez et al., 1996) RT-PCR Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism   (Ratnaparkhi et al., 2002) adult stage | male   organism   (Ratnaparkhi et al., 2002) adult stage | female   organism   (Ratnaparkhi et al., 2002) adult stage   adult head   (Ratnaparkhi et al., 2002, Boto et al., 2010) appendage   (Ratnaparkhi et al., 2002) third segment of antenna   (Boto et al., 2010) Comment:all isoforms except Gq-RD (Gα49B-RD) maxillary palpus   (Boto et al., 2010) Comment:all isoforms except Gq-RD (Gα49B-RD)
Additional Descriptive Data
	RT-PCR analysis shows that the isoforms -RA, -RB, -RC, -RE, -RG and -RH of G-iα65A are expressed in the adult head, third segment of the antenna and maxillary palps. The isoform Gα49B-RD is only detected in the adult head. (Boto et al., 2010) Eye-enriched transcripts determined by ratio of expression level in wild-type heads. versus expression level in so heads. (Xu et al., 2004)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 12 -- 13   epithelium of embryonic/larval midgut primordium   (Ratnaparkhi et al., 2002) embryonic stage 12 -- 17   presumptive embryonic/larval central nervous system   • axonal growth cone (Ratnaparkhi et al., 2002) embryonic stage 13 -- 17   embryonic fiber tract   (Ratnaparkhi et al., 2002) pupal stage P6 -- adult stage   adult olfactory receptor neuron   (Kain et al., 2008) antenna | restricted   (Kain et al., 2008) third segment of antenna | restricted   (Kain et al., 2008) adult stage   rhabdomere   (Lee et al., 1994) lamina   (Schulz et al., 1999, Talluri et al., 1995) eye   (Lee et al., 1994) ocellus   (Lee et al., 1994) photoreceptor cell   (Schulz et al., 1999) third segment of antenna   (Talluri et al., 1995) proboscis | restricted   (Talluri et al., 1995) maxillary palpus   (Talluri et al., 1995) medulla   (Schulz et al., 1999) third segment of antenna | restricted   (Boto et al., 2010) olfactory sensory organ | subset   (Boto et al., 2010) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Dorus et al., 2006) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011) western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism   (Ratnaparkhi et al., 2002) adult stage   head   (Ratnaparkhi et al., 2002) adult head   (Tian et al., 2013)
Additional Descriptive Data
	Gα49B protein is localized to the photoreceptor cells of the retina. It is also detected in the lamina and the medulla, presumably in axons of the photoreceptor cells that project to these optic ganglia. (Schulz et al., 1999) In adult head sections, this Gα49B protein isoform localizes to the third antennal segment, the maxillary palps, the tip of the proboscis, and the lamina. A subset of the staining detected in the third antennal segment localizes to olfactory neurons. (Talluri et al., 1995) Gα49B protein is expressed in the neurons, neuronal processes and non-neuronal tissues of the third segment of the antenna. It co-localises with G-iα65A protein. (Boto et al., 2010) Gα49B proteins are detected in all rhabdomeres of the eye, and in ocelli. (Lee et al., 1994)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
inaD signaling complex inferred from direct assay (Bahner et al., 2000) plasma membrane inferred from direct assay (Khanna et al., 2010) rhabdomere inferred from direct assay (Lee et al., 1994)
Expression Deduced from Reporters
Reporter: P{dGq-LacZ} Stage Tissue/Position (including subcellular localization) Reference adult stage   adult central nervous system | restricted   (Talluri et al., 1995) proboscis   (Talluri et al., 1995) antenna   (Talluri et al., 1995) pupal/adult digestive system | restricted   (Talluri et al., 1995) lamina   (Talluri et al., 1995) maxillary palpus   (Talluri et al., 1995)
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, larval/adult fat body, larval/adult salivary gland, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    57 central nervous system, pupae P8    101 head, virgin 1-day female    115 head, virgin 4-day female    81 head, virgin 20-day female    53 head, mated 1-day female    104 head, mated 4-day female    70 head, mated 20-day female    48 head, mated 1-day male    139 head, mated 4-day male    116 head, mated 20-day male    108 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    21 digestive system, 1-day adult    15 digestive system, 4-day adult    18 digestive system, 20-day adult    10 fat body, larvae L3 wandering    11 fat body, white prepupae    28 fat body, pupae P8    25 carcass, larvae L3 wandering    21 carcass, 1-day adult    15 carcass, 4-day adult    18 carcass, 20-day adult    13 ovary, virgin 4-day female    48 ovary, mated 4-day female    40 testis, mated 4-day male    9 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3  (57) central nervous system, pupae P8  (101) head, virgin 1-day female  (115) head, virgin 4-day female  (81) head, virgin 20-day female  (53) head, mated 1-day female  (104) head, mated 4-day female  (70) head, mated 20-day female  (48) head, mated 1-day male  (139) head, mated 4-day male  (116) head, mated 20-day male  (108) salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    21 digestive system, 1-day adult    15 digestive system, 4-day adult    18 digestive system, 20-day adult    10 fat body, larvae L3 wandering    11 fat body, white prepupae  (28) fat body, pupae P8    25 carcass, larvae L3 wandering    21 carcass, 1-day adult    15 carcass, 4-day adult    18 carcass, 20-day adult    13 ovary, virgin 4-day female  (48) ovary, mated 4-day female  (40) testis, mated 4-day male    9 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    57 central nervous system, pupae P8  101 head, virgin 1-day female  (115) head, virgin 4-day female    81 head, virgin 20-day female    53 head, mated 1-day female  104 head, mated 4-day female    70 head, mated 20-day female    48 head, mated 1-day male  (139) head, mated 4-day male  (116) head, mated 20-day male  (108) salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    21 digestive system, 1-day adult    15 digestive system, 4-day adult    18 digestive system, 20-day adult    10 fat body, larvae L3 wandering    11 fat body, white prepupae    28 fat body, pupae P8    25 carcass, larvae L3 wandering    21 carcass, 1-day adult    15 carcass, 4-day adult    18 carcass, 20-day adult    13 ovary, virgin 4-day female    48 ovary, mated 4-day female    40 testis, mated 4-day male    9 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    57 central nervous system, pupae P8    101 head, virgin 1-day female    115 head, virgin 4-day female    81 head, virgin 20-day female    53 head, mated 1-day female    104 head, mated 4-day female    70 head, mated 20-day female    48 head, mated 1-day male    139 head, mated 4-day male    116 head, mated 20-day male    108 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    21 digestive system, 1-day adult    15 digestive system, 4-day adult    18 digestive system, 20-day adult    10 fat body, larvae L3 wandering    11 fat body, white prepupae    28 fat body, pupae P8    25 carcass, larvae L3 wandering    21 carcass, 1-day adult    15 carcass, 4-day adult    18 carcass, 20-day adult    13 ovary, virgin 4-day female    48 ovary, mated 4-day female    40 testis, mated 4-day male    9 accessory gland, mated 4-day male    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    57 central nervous system, pupae P8    101 head, virgin 1-day female    115 head, virgin 4-day female    81 head, virgin 20-day female    53 head, mated 1-day female    104 head, mated 4-day female    70 head, mated 20-day female    48 head, mated 1-day male    139 head, mated 4-day male    116 head, mated 20-day male    108 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    21 digestive system, 1-day adult    15 digestive system, 4-day adult    18 digestive system, 20-day adult    10 fat body, larvae L3 wandering    11 fat body, white prepupae    28 fat body, pupae P8    25 carcass, larvae L3 wandering    21 carcass, 1-day adult    15 carcass, 4-day adult    18 carcass, 20-day adult    13 ovary, virgin 4-day female    48 ovary, mated 4-day female    40 testis, mated 4-day male    9 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3  (57) central nervous system, pupae P8  (101) head, virgin 1-day female  (115) head, virgin 4-day female  (81) head, virgin 20-day female  (53) head, mated 1-day female  (104) head, mated 4-day female  (70) head, mated 20-day female  (48) head, mated 1-day male  (139) head, mated 4-day male  (116) head, mated 20-day male  (108) salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    21 digestive system, 1-day adult    15 digestive system, 4-day adult    18 digestive system, 20-day adult    10 fat body, larvae L3 wandering    11 fat body, white prepupae  28 fat body, pupae P8    25 carcass, larvae L3 wandering    21 carcass, 1-day adult    15 carcass, 4-day adult    18 carcass, 20-day adult    13 ovary, virgin 4-day female  (48) ovary, mated 4-day female  (40) testis, mated 4-day male    9 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    57 central nervous system, pupae P8  101 head, virgin 1-day female  115 head, virgin 4-day female    81 head, virgin 20-day female    53 head, mated 1-day female  104 head, mated 4-day female    70 head, mated 20-day female    48 head, mated 1-day male  139 head, mated 4-day male  116 head, mated 20-day male  108 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    21 digestive system, 1-day adult    15 digestive system, 4-day adult    18 digestive system, 20-day adult    10 fat body, larvae L3 wandering    11 fat body, white prepupae    28 fat body, pupae P8    25 carcass, larvae L3 wandering    21 carcass, 1-day adult    15 carcass, 4-day adult    18 carcass, 20-day adult    13 ovary, virgin 4-day female    48 ovary, mated 4-day female    40 testis, mated 4-day male    9 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    57 central nervous system, pupae P8    101 head, virgin 1-day female    115 head, virgin 4-day female    81 head, virgin 20-day female    53 head, mated 1-day female    104 head, mated 4-day female    70 head, mated 20-day female    48 head, mated 1-day male    139 head, mated 4-day male    116 head, mated 20-day male    108 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    21 digestive system, 1-day adult    15 digestive system, 4-day adult    18 digestive system, 20-day adult    10 fat body, larvae L3 wandering    11 fat body, white prepupae    28 fat body, pupae P8    25 carcass, larvae L3 wandering    21 carcass, 1-day adult    15 carcass, 4-day adult    18 carcass, 20-day adult    13 ovary, virgin 4-day female    48 ovary, mated 4-day female    40 testis, mated 4-day male    9 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    12 embryo 02-04hr    10 embryo 04-06hr    11 embryo 06-08hr    11 embryo 08-10hr    14 embryo 10-12hr    10 embryo 12-14hr    20 embryo 14-16hr    7 embryo 16-18hr    13 embryo 18-20hr    8 embryo 20-22hr    7 embryo 22-24hr    12 larva L1    7 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    15 white prepupae new    16 white prepupae 12hr    15 white prepupae 24hr    17 pupae 2d postWPP    19 pupae 3d postWPP    13 pupae 4d postWPP    26 adult male 01day    26 adult male 05day    20 adult male 30day    15 adult female 01day    14 adult female 05day    16 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    12 embryo 02-04hr    10 embryo 04-06hr    11 embryo 06-08hr    11 embryo 08-10hr    14 embryo 10-12hr    10 embryo 12-14hr    20 embryo 14-16hr    7 embryo 16-18hr    13 embryo 18-20hr    8 embryo 20-22hr    7 embryo 22-24hr    12 larva L1    7 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    15 white prepupae new    16 white prepupae 12hr    15 white prepupae 24hr    17 pupae 2d postWPP    19 pupae 3d postWPP    13 pupae 4d postWPP  26 adult male 01day  26 adult male 05day    20 adult male 30day    15 adult female 01day    14 adult female 05day    16 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    12 embryo 02-04hr    10 embryo 04-06hr    11 embryo 06-08hr    11 embryo 08-10hr    14 embryo 10-12hr    10 embryo 12-14hr    20 embryo 14-16hr    7 embryo 16-18hr    13 embryo 18-20hr    8 embryo 20-22hr    7 embryo 22-24hr    12 larva L1    7 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    15 white prepupae new    16 white prepupae 12hr    15 white prepupae 24hr    17 pupae 2d postWPP    19 pupae 3d postWPP    13 pupae 4d postWPP    26 adult male 01day    26 adult male 05day    20 adult male 30day    15 adult female 01day    14 adult female 05day    16 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    12 embryo 02-04hr    10 embryo 04-06hr    11 embryo 06-08hr    11 embryo 08-10hr    14 embryo 10-12hr    10 embryo 12-14hr    20 embryo 14-16hr    7 embryo 16-18hr    13 embryo 18-20hr    8 embryo 20-22hr    7 embryo 22-24hr    12 larva L1    7 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    15 white prepupae new    16 white prepupae 12hr    15 white prepupae 24hr    17 pupae 2d postWPP    19 pupae 3d postWPP    13 pupae 4d postWPP    26 adult male 01day    26 adult male 05day    20 adult male 30day    15 adult female 01day    14 adult female 05day    16 adult female 30day    13 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    12 embryo 02-04hr    10 embryo 04-06hr    11 embryo 06-08hr    11 embryo 08-10hr    14 embryo 10-12hr    10 embryo 12-14hr    20 embryo 14-16hr    7 embryo 16-18hr    13 embryo 18-20hr    8 embryo 20-22hr    7 embryo 22-24hr    12 larva L1    7 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    15 white prepupae new    16 white prepupae 12hr    15 white prepupae 24hr    17 pupae 2d postWPP    19 pupae 3d postWPP    13 pupae 4d postWPP    26 adult male 01day    26 adult male 05day    20 adult male 30day    15 adult female 01day    14 adult female 05day    16 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    12 embryo 02-04hr    10 embryo 04-06hr    11 embryo 06-08hr    11 embryo 08-10hr    14 embryo 10-12hr    10 embryo 12-14hr    20 embryo 14-16hr    7 embryo 16-18hr    13 embryo 18-20hr    8 embryo 20-22hr    7 embryo 22-24hr    12 larva L1    7 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    15 white prepupae new    16 white prepupae 12hr    15 white prepupae 24hr    17 pupae 2d postWPP    19 pupae 3d postWPP    13 pupae 4d postWPP  26 adult male 01day  26 adult male 05day    20 adult male 30day    15 adult female 01day    14 adult female 05day    16 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    12 embryo 02-04hr    10 embryo 04-06hr    11 embryo 06-08hr    11 embryo 08-10hr    14 embryo 10-12hr    10 embryo 12-14hr    20 embryo 14-16hr    7 embryo 16-18hr    13 embryo 18-20hr    8 embryo 20-22hr    7 embryo 22-24hr    12 larva L1    7 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    15 white prepupae new    16 white prepupae 12hr    15 white prepupae 24hr    17 pupae 2d postWPP    19 pupae 3d postWPP    13 pupae 4d postWPP    26 adult male 01day    26 adult male 05day    20 adult male 30day    15 adult female 01day    14 adult female 05day    16 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    12 embryo 02-04hr    10 embryo 04-06hr    11 embryo 06-08hr    11 embryo 08-10hr    14 embryo 10-12hr    10 embryo 12-14hr    20 embryo 14-16hr    7 embryo 16-18hr    13 embryo 18-20hr    8 embryo 20-22hr    7 embryo 22-24hr    12 larva L1    7 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    15 white prepupae new    16 white prepupae 12hr    15 white prepupae 24hr    17 pupae 2d postWPP    19 pupae 3d postWPP    13 pupae 4d postWPP    26 adult male 01day    26 adult male 05day    20 adult male 30day    15 adult female 01day    14 adult female 05day    16 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    39 Schneider line 2 Sg4    36 embryonic 1182-4H    17 embryonic GM2    66 embryonic Kc167    64 embryonic S1    24 embryonic S3    103 leg disc CME L1    30 wing disc CME-W2    78 wing disc ML-DmD8    32 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    40 wing disc ML-DmD21    9 wing disc ML-DmD32    24 haltere disc ML-DmD17-c3    30 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2    71 tumorous blood cells mbn2    88 ovary fGS/OSS    18 ovary OSC    34 ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (39) Schneider line 2 Sg4  (36) embryonic 1182-4H    17 embryonic GM2  (66) embryonic Kc167  (64) embryonic S1    24 embryonic S3  (103) leg disc CME L1  (30) wing disc CME-W2  (78) wing disc ML-DmD8  (32) wing disc ML-DmD9    15 wing disc ML-DmD16-c3  (40) wing disc ML-DmD21    9 wing disc ML-DmD32    24 haltere disc ML-DmD17-c3  (30) eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2  (71) tumorous blood cells mbn2  (88) ovary fGS/OSS    18 ovary OSC  (34) ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    39 Schneider line 2 Sg4    36 embryonic 1182-4H    17 embryonic GM2    66 embryonic Kc167    64 embryonic S1    24 embryonic S3  103 leg disc CME L1    30 wing disc CME-W2    78 wing disc ML-DmD8    32 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    40 wing disc ML-DmD21    9 wing disc ML-DmD32    24 haltere disc ML-DmD17-c3    30 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2    71 tumorous blood cells mbn2    88 ovary fGS/OSS    18 ovary OSC    34 ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    39 Schneider line 2 Sg4    36 embryonic 1182-4H    17 embryonic GM2    66 embryonic Kc167    64 embryonic S1    24 embryonic S3    103 leg disc CME L1    30 wing disc CME-W2    78 wing disc ML-DmD8    32 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    40 wing disc ML-DmD21    9 wing disc ML-DmD32    24 haltere disc ML-DmD17-c3    30 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2    71 tumorous blood cells mbn2    88 ovary fGS/OSS    18 ovary OSC    34 ovary OSS    20 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    39 Schneider line 2 Sg4    36 embryonic 1182-4H    17 embryonic GM2    66 embryonic Kc167    64 embryonic S1    24 embryonic S3    103 leg disc CME L1    30 wing disc CME-W2    78 wing disc ML-DmD8    32 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    40 wing disc ML-DmD21    9 wing disc ML-DmD32    24 haltere disc ML-DmD17-c3    30 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2    71 tumorous blood cells mbn2    88 ovary fGS/OSS    18 ovary OSC    34 ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (39) Schneider line 2 Sg4  (36) embryonic 1182-4H    17 embryonic GM2  (66) embryonic Kc167  (64) embryonic S1    24 embryonic S3  (103) leg disc CME L1  30 wing disc CME-W2  (78) wing disc ML-DmD8  32 wing disc ML-DmD9    15 wing disc ML-DmD16-c3  (40) wing disc ML-DmD21    9 wing disc ML-DmD32    24 haltere disc ML-DmD17-c3  30 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2  (71) tumorous blood cells mbn2  (88) ovary fGS/OSS    18 ovary OSC  (34) ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    39 Schneider line 2 Sg4    36 embryonic 1182-4H    17 embryonic GM2    66 embryonic Kc167    64 embryonic S1    24 embryonic S3  103 leg disc CME L1    30 wing disc CME-W2    78 wing disc ML-DmD8    32 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    40 wing disc ML-DmD21    9 wing disc ML-DmD32    24 haltere disc ML-DmD17-c3    30 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2    71 tumorous blood cells mbn2    88 ovary fGS/OSS    18 ovary OSC    34 ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    39 Schneider line 2 Sg4    36 embryonic 1182-4H    17 embryonic GM2    66 embryonic Kc167    64 embryonic S1    24 embryonic S3    103 leg disc CME L1    30 wing disc CME-W2    78 wing disc ML-DmD8    32 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    40 wing disc ML-DmD21    9 wing disc ML-DmD32    24 haltere disc ML-DmD17-c3    30 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2    71 tumorous blood cells mbn2    88 ovary fGS/OSS    18 ovary OSC    34 ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    10 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    70 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    40 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    36 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    35 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    10 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult  (39) Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult  (70) Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult  (40) Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (36) Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult  (35) Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    10 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    70 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    40 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    36 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    35 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    10 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    70 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    40 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    36 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    35 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    10 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    70 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    40 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    36 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    35 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    10 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult  (39) Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult  (70) Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult  (40) Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (36) Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult  (35) Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    10 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    70 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    40 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    36 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    35 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    10 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    70 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    40 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    36 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    35 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_21 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • IP15229 LD13901 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004435 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17759-RA;CG17759-RD FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Gαq Stages(s) 1-3 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with Df(2R)vg-C) Gαq221c Gαq1370 lethal (with Gαq221c) Gαq1370 lethal (with Gαq1370) Gαq221c lethal | first instar larval stage Gαq221c Gαqf04219 lethal | larval stage | recessive Gαq221c Gαq1370 viable (with Gαq1) Gαq221c Gαq1370 viable (with Gαq221c) Gαq1 viable (with Gαq1370) Gαq1 Other Phenotypes Allele behavior defective | recessive Gαq1 flightless | partially, with Scer\GAL4Ddc.PL GαqdsRNA.Scer\UAS.1f1 immune response defective Gαq1 neuroanatomy defective, with Scer\GAL4ap-md544 GαqQ203L.Scer\UAS neuroanatomy defective, with Scer\GAL4elav-C155 GαqQ203L.Scer\UAS neuroanatomy defective, with Scer\GAL4ftz.ng GαqQ203L.Scer\UAS neuroanatomy defective | embryonic stage, with Scer\GAL415J2 GαqQ203L.Scer\UAS neurophysiology defective Gαq1 Gαq961 neurophysiology defective, with Scer\GAL4GMR.PF GαqdsRNA.Scer\UAS neurophysiology defective, with Scer\GAL4Gα49B.PS GαqdsRNA.Scer\UAS.1f1 neurophysiology defective, with Scer\GAL4hs.PB GαqQ203L.Scer\UAS neurophysiology defective, with Scer\GAL4Orco.2.642.T:Hsim\VP22 GαqdsRNA.Scer\UAS.1f1 neurophysiology defective (with Df(2R)Exel7121) Gαq961 neurophysiology defective (with Gαq1) Gαq961 neurophysiology defective (with Gαq961) Gαq1 neurophysiology defective | dominant Gαq221c Gαq1370 neurophysiology defective | heat sensitive, with Scer\GAL4hs.PU GαqQ203L.Scer\UAS neurophysiology defective | somatic clone Gαq221c Gαq1370 sensory perception defective, with Scer\GAL4Gr21a.9.323 GαqdsRNA.Scer\UAS.1f1 GαqdsRNA.Scer\UAS Gαqpept.Scer\UAS GαqQ203L.Scer\UAS smell perception defective GαqdsRNA.Scer\UAS smell perception defective, with Scer\GAL4c309 GαqdsRNA.Scer\UAS smell perception defective, with Scer\GAL4Orco.T:Hsim\VP16 GαqdsRNA.Scer\UAS GαqQ203L.Scer\UAS smell perception defective, with Scer\GAL4Tab2-201Y GαqdsRNA.Scer\UAS smell perception defective | heat sensitive, with Scer\GAL4hs.PU GαqQ203L.Scer\UAS smell perception defective | heat sensitive, with Scer\GAL80ts.αTub84B GαqdsRNA.Scer\UAS.1f1 GαqdsRNA.Scer\UAS thermotaxis behavior defective Gαq1 thermotaxis behavior defective, with Scer\GAL4TrpA1.PR GαqdsRNA.Scer\UAS thermotaxis behavior defective | larval stage, with Scer\GAL4ninaE.PT GαqJF01209 visual behavior defective | recessive Gαq1 wild-type Gαq1.hs Phenotype manifest in Allele adult olfactory receptor neuron Gr21a/63a, with Scer\GAL4Gr21a.9.323 Gαqpept.Scer\UAS GαqQ203L.Scer\UAS GαqdsRNA.Scer\UAS GαqdsRNA.Scer\UAS.1f1 adult olfactory receptor neuron Gr21a/63a | heat sensitive, with Scer\GAL4hs.PU GαqQ203L.Scer\UAS adult olfactory receptor neuron Or22, with Scer\GAL4Orco.T:Hsim\VP16 GαqQ203L.Scer\UAS adult olfactory receptor neuron Or42b, with Scer\GAL4Orco.T:Hsim\VP16 GαqQ203L.Scer\UAS adult olfactory receptor neuron Or59b, with Scer\GAL4Gα49B.PS GαqdsRNA.Scer\UAS.1f1 adult olfactory receptor neuron Or59b, with Scer\GAL4Orco.T:Hsim\VP16 GαqQ203L.Scer\UAS adult olfactory receptor neuron Or59b | somatic clone Gαq1370 commissure | embryonic stage, with Scer\GAL4elav-C155 GαqQ203L.Scer\UAS dMP2 neuron, with Scer\GAL415J2 GαqQ203L.Scer\UAS eye photoreceptor cell Gαq1 Gαq961 fascicle | embryonic stage, with Scer\GAL4ap-md544 GαqQ203L.Scer\UAS fascicle | embryonic stage, with Scer\GAL4elav-C155 GαqQ203L.Scer\UAS fascicle | embryonic stage, with Scer\GAL4ftz.ng GαqQ203L.Scer\UAS neuropil | embryonic stage, with Scer\GAL4elav-C155 GαqQ203L.Scer\UAS pCC neuron, with Scer\GAL4ftz.ng GαqQ203L.Scer\UAS photoreceptor Gαq1 photoreceptor cell Gαq1 photoreceptor cell, with Scer\GAL4GMR.PF GαqdsRNA.Scer\UAS retina | conditional Gαq1 Gαq961 rhabdomere Gαq1 wing, with Scer\GAL4Ddc.PL GαqScer\UAS.cRa
Classical Alleles ( 10 )
For All Classical Alleles Show
Allele of Gαq Class Mutagen Stocks Known lesion Gαqf04219 piggyBac transposase 3 -- Gαq1370 ethyl methanesulfonate 1 Yes Gαq1 hypomorphic allele - genetic evidence ethyl methanesulfonate 1 Yes Gαq221c P-element activity 1 Yes GαqKG07081 P-element activity 1 -- GαqKG07290 P-element activity 1 -- GαqNP1136 1 -- GαqNP6216 1 -- Gαq961 amorphic allele - molecular evidence ethyl methanesulfonate 0 Yes Gαq28 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 23 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Gαq Class Mutagen Stocks Known lesion GαqGD17761 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes GαqdsRNA.Scer\UAS.1f1 in vitro construct - RNAi 1 Yes GαqGL01048 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes GαqJF01209 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes GαqJF02390 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes GαqJF02464 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes GαqKK109283 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes GαqQ203L.Scer\UAS in vitro construct - site directed mutagenesis in vitro construct - regulatory fusion in vitro construct - amino acid replacement 1 Yes GαqScer\UAS.cRa in vitro construct - regulatory fusion 1 Yes Gαq1.hs in vitro construct - regulatory fusion 0 Yes Gαq1.Q203L in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes Gαq2.hs in vitro construct - regulatory fusion 0 Yes Gαq2.Q203L in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes GαqdsRNA.cHa.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes GαqdsRNA.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes GαqH212A.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes Gαqm1 in vitro construct - minigene 0 Yes Gαqm2 in vitro construct - minigene 0 Yes GαqNIG.17759R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Gαqpept.Scer\UAS in vitro construct - regulatory fusion 0 Yes GαqQ203L.Scer\UAS.cPa in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes Gαqscrambledpept.Scer\UAS in vitro construct - regulatory fusion 0 Yes GαqVDRC.cUa in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel7121 (Ryder, 2004.4.26, Hu et al., 2012) Df(2R)vg135 (Lee et al., 1994, Scott et al., 1995, Zars and Hyde, 1996, Meyer et al., 2006) Df(2R)vg-C (Ratnaparkhi et al., 2002, Kain et al., 2008)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}GαqKG07081 NA P{SUPor-P}GαqKG07290 NA PBac{WH}Gαqf04219 NA insertion of enhancer trap binary system P{GawB}GαqNP1136 No P{GawB}GαqNP6216 No
Gene Ontology: Function, Process & Cellular Component ( 26 unique terms )
Terms Based on Experimental Evidence ( 16 terms )
Molecular Function
CV term Evidence References
GTPase activity inferred from mutant phenotype (Lee et al., 1994)
Biological Process
CV term Evidence References
activation of phospholipase C activity inferred from genetic interaction with norpA (Lee et al., 1994) inferred from genetic interaction with rdgB (Lee et al., 1994) inferred from physical interaction with norpA (Bahner et al., 2000) axon midline choice point recognition inferred from mutant phenotype (Ratnaparkhi et al., 2002) cellular response to carbon dioxide inferred from mutant phenotype (Yao and Carlson, 2010) flight behavior inferred from genetic interaction with Itp-r83A (Banerjee et al., 2006) metarhodopsin inactivation inferred from mutant phenotype (Hu et al., 2012) mucosal immune response inferred from mutant phenotype (Ha et al., 2009) negative regulation of compound eye retinal cell programmed cell death inferred from mutant phenotype (Iakhine et al., 2004) phototransduction inferred from direct assay (Elia et al., 2005) inferred from expression pattern (Lee et al., 1994) inferred from mutant phenotype (Lee et al., 1994) rhodopsin mediated signaling pathway inferred from mutant phenotype (Lee et al., 1994) sensory perception of smell inferred from mutant phenotype (Kain et al., 2008) stabilization of membrane potential inferred from genetic interaction with Itp-r83A (Banerjee et al., 2006) thermotaxis inferred from direct assay (Kwon et al., 2008) inferred from mutant phenotype (Shen et al., 2011)
Cellular Component
CV term Evidence References
inaD signaling complex inferred from direct assay (Bahner et al., 2000) plasma membrane inferred from direct assay (Khanna et al., 2010) rhabdomere inferred from direct assay (Lee et al., 1994)
Terms Based on Predictions or Assertions ( 13 terms )
Molecular Function
CV term Evidence References
G-protein beta/gamma-subunit complex binding inferred from biological aspect of ancestor with PANTHER:PTN000026392 (assigned by RefGenome) (Gaudet et al., 2010) G-protein coupled receptor binding inferred from biological aspect of ancestor with PANTHER:PTN000026392 (assigned by RefGenome) (Gaudet et al., 2010) GTPase activity inferred from sequence or structural similarity with mouse Gnaq (Strathmann and Simon, 1990) non-traceable author statement (Swiss-Prot Project Members, 1991.11.1) GTP binding inferred from electronic annotation with InterPro:IPR000654 (FlyBase Curators et al., 2004-) signal transducer activity inferred from biological aspect of ancestor with PANTHER:PTN000026392 (assigned by RefGenome) (Gaudet et al., 2010)
Biological Process
CV term Evidence References
adenylate cyclase-modulating G-protein coupled receptor signaling pathway inferred from biological aspect of ancestor with PANTHER:PTN000026392 (assigned by RefGenome) (Gaudet et al., 2010) G-protein coupled receptor signaling pathway non-traceable author statement (Swiss-Prot Project Members, 1991.11.1) GTP catabolic process inferred from electronic annotation with InterPro:IPR000654 (FlyBase Curators et al., 2004-) phospholipase C-activating dopamine receptor signaling pathway inferred from biological aspect of ancestor with PANTHER:PTN000026396 (assigned by RefGenome) (Gaudet et al., 2010) phototransduction traceable author statement (Montell, 1999)
Cellular Component
CV term Evidence References
extrinsic to internal side of plasma membrane inferred from biological aspect of ancestor with PANTHER:PTN000026392 (assigned by RefGenome) (Gaudet et al., 2010) heterotrimeric G-protein complex inferred from biological aspect of ancestor with PANTHER:PTN000026392 (assigned by RefGenome) (Gaudet et al., 2010) inferred from sequence or structural similarity with mouse Gnaq (Strathmann and Simon, 1990) non-traceable author statement (Swiss-Prot Project Members, 1991.11.1) rhabdomere traceable author statement (Montell, 1999)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Gαq - B52 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gαq - CG11107 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gαq - CG4611 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gαq - CG6701 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gαq - CG7048 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gαq - CG7137 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gαq - CG7770 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gαq - CG7878 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gαq - Gγ1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gαq - Hsp23 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gαq - M6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gαq - Rsf1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gαq - Syp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gαq - Upf1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gαq - Zn72D anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gαq - l(3)01239 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gαq - mgr anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gαq - mib2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gαq - qkr54B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gαq - εCOP anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Gαq allele Gene References Gα49B1 rdgA (Hardie et al., 2002) rdgC (Kiselev et al., 2000) Gα49BQ203L.Scer\UAS fra (Ratnaparkhi et al., 2002) robo (Ratnaparkhi et al., 2002) unspecified Camta (Han et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62158 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0004435 DroID - A comprehensive database of gene and protein interactions. • FBgn0004435 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36384
Orthologs
OrthoDB Orthologs (54) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG67DB1X Dipteran inclusive ortholog search EOG6C2HK0 Insect inclusive ortholog search EOG6SN0J6 Arthropod inclusive ortholog search EOG6XD26H Metazoa inclusive ortholog search EOG68SVMV
Orthologs in Drosophila Species (EOG67DB1X)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Gαq     Drosophila simulans   Dsim\GD10904 Y   Drosophila sechellia   Dsec\GM21408 Y   Drosophila erecta   Dere\GG20320 Y   Drosophila yakuba   Dyak\GE12481 Y   Drosophila ananassae   Dana\GF13398 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA14650 Y   Drosophila persimilis   Dper\GL20009 Y   Drosophila willistoni   Dwil\GK23154 Y   Drosophila virilis   Dvir\GJ22327 Y   Drosophila mojavensis   Dmoj\GI20476     Drosophila grimshawi   Dgri\GH21190
Orthologs in non-Drosophila Dipterans (EOG6C2HK0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL010506   Anopheles gambiae Malaria mosquito  Agam\AGAP005079   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ010818
Orthologs in non-Dipteran Insects (EOG6SN0J6)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB43282   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007947   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH23562   Atta cephalotes Leafcutter ant  Acep\ACEP15525   Camponotus floridanus Florida carpenter ant  Cflo\CFLO16396   Camponotus floridanus Florida carpenter ant  Cflo\CFLO11830   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16610   Linepithema humile Argentine ant  Lhum\LH24916   Pogonomyrmex barbatus Red harvester ant  Pbar\PB16291   Solenopsis invicta Red fire ant  Sinv\SINV14693   Acyrthosiphon pisum Pea aphid  Apim\ACYPI004308   Bombyx mori Silkmoth  Bmor\BGIBMGA012492   Pediculus humanus Human body louse  Phum\PHUM157770   Tribolium castaneum Red flour beetle  Tcas\TC000634
Orthologs in non-Insect Arthropods (EOG6XD26H)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\srh-264   Daphnia pulex Water flea  Dpux\Gnaq2   Ixodes scapularis Deer tick  Isca\ISCW008109
Orthologs in non-Arthropod Metazoa (EOG68SVMV)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\egl-30 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003898gn Y Danio rerio Zebrafish  Drer\gna14a Y Danio rerio Zebrafish  Drer\gna14 Y Danio rerio Zebrafish  Drer\gnaq Y Danio rerio Zebrafish  Drer\gna11 Y Danio rerio Zebrafish  Drer\gna11b Y Xenopus tropicalis Western clawed frog  Xtro\gna14 Y Xenopus tropicalis Western clawed frog  Xtro\gnaq Y Xenopus tropicalis Western clawed frog  Xtro\gna11 Y Gallus gallus Domestic chicken  Ggal\GNA11 Y Gallus gallus Domestic chicken  Ggal\GNA14 Y Gallus gallus Domestic chicken  Ggal\ENSGALG00000003238 Y Mus musculus House mouse  Mmus\Gna14 Y Mus musculus House mouse  Mmus\Gnaq Y Mus musculus House mouse  Mmus\Gna11 Y Rattus norvegicus Norway rat  Rnor\Gna11 Y Rattus norvegicus Norway rat  Rnor\Gnaq Y Rattus norvegicus Norway rat  Rnor\Gna14 Y Homo sapiens Human  Hsap\GNAQ Y Homo sapiens Human  Hsap\GNA14 Y Homo sapiens Human  Hsap\GNA11 Y
Human Orthologs (3)
Gene OMIM HGNC Hsap\GNAQ     Hsap\GNA14     Hsap\GNA11
AAA Orthologs (9) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD10904 Drosophila sechellia Dsec\GM21408 Drosophila erecta Dere\GG20320 Drosophila yakuba Dyak\GE12481 Drosophila ananassae Dana\GF13398 Drosophila pseudoobscura pseudoobscura Dpse\GA14650 Drosophila persimilis Dper\GL20009 Drosophila willistoni Dwil\GK23154 Drosophila virilis Dvir\GJ22327
Stocks & Reagents
Stocks Listed in FlyBase ( 20 )
Bloomington	30736 Gαq1370/CyO 42257 cn1 Gαq1 30734 w*; P{UAS-Gα49B.R}2 33765 y1 v1; P{TRiP.JF02464}attP2 36775 y1 v1; P{TRiP.JF02390}attP2 18745 w1118; PBac{WH}Gαqf04219/CyO 30744 w*; Gαq221c/CyO, P{ActGFP}JMR1 30735 w*; P{UAS-Gα49B.dsRNA.1f1}2/CyO, P{ActGFP}JMR1
Harvard	- PBac{WH}Gαqf04219
VDRC	v105300 P{KK109283}VIE-260B v51116 w1118 P{GD17761}v51116 v50729 w1118; P{GD17761}v50729
	More stocks available...
Genomic Clones ( 2 )
	BACR24H09 BACR27F05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 243 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM01501 IP15229 LD13901 LP09564
Other clones	DPiM_LD13901
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH05204 GH10384 GH28437 HL01038 HL01189 HL03633 HL04025 HL05806 HL06664 LD06744 LD09778 LD17923 LD19339 LD32085 RE05502 RE05542 RE05553 RE09490 RE10146 RE14583 RE54585 RE57167 RE64815 RE67275 RH02351 RH02972 RH03849 RH04859 RH05381 RH05831 RH06412 RH07549 RH08774 RH08815 RH26167 RH34505 RH34515 RH43707 RH47108 RH47425 RH52396 RH54449 RH55737 RH56715 RH58876 RH59341 RH60568 RH66484 RH68293 RH70042 RH70548 RH70552 RH71541 SD07643
Other clones	14917 29171 35231 35319 35830 38274 38558 45696 55210 58644 60773 62727 63876 65716 66753 66838 71444 71843 73369 73640 74398 75232 75409 77030 80736 80988 82118 84339 100692 102332 102910 103582 104181 108571 108603 108767 118107 119902 125715 125716 144710 146911 147067 148816 153498 158324 160241 162095 172761 172790 177431 192713 194548 194883 214213.33 214223.26 214247.33 214351.34 214351.35 214379.24 214379.25 214379.26 214415.32 214447.35 214571.34 214577.19 214577.20 272974 273521 276684 281705 525474 CK01.8A.E2 CK01.53B.G8 CK01.71A.D3 CK01.85D.D10 CK01.88C.B6 CK01.88C.E6 CK01.89B.H8 CK01.128D.E10 CK01.167C.C6 CK01.170C.G8 Dmel_dig_019408_0649_0903 DMG5-chr2R.15.003.pred.a EC00174 EC00274 EC13138 EK010949 EK022202 EK038762 EK043060 EK053609 EK056414 EK060626 EK067945 EK069739 EK069751 EK070246 EK070513 EK070738 EK095408 EK097927 EK103043 EK104108 EK104743 EK104925 EK110546 EK111145 EK143457 EK145546 EK146461 EK150424 EK152234 EK160663 EK161818 EK165857 EK174008 EK181141 EK182922 EK185136 EK185139 EK185662 EK190512 EK193253 EK194750 EK199339 EK200660 EK202541 EK205229 EK207450 EK207640 EK209951 EK213261 EK213857 EK218942 EK226545 EK227729 EK235418 EK235448 EK237410 EK239709 EK239742 EK242638 EK247713 EK249556 EK249558 EK252060 EK255247 EK257037 EK261345 EK263259 EK271101 EK273238 EK291022 EK295705 EK296345 EK298003 EK298129 EK303540 EK307015 EK308206 EN06560 EP06541 EP06831 EP06837 EP08039 EP08131 EP08315 EP09003 EP09157 EP09452 EP10443 EP10905 EP10947 EP11004 EP19936 FGM305G11 IP15329 IP15429 IP15529 LD10619 RH01290 RP004505759 UUGC1015
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004435 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36384
Antibody Information
	polyclonal (Lee et al., 1994, Katz and Minke, 2012, Rosenbaum et al., 2012, Talluri et al., 1995)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Gα49B CG17759 (Gabrielian, 1999.11) Source for identity of: Gαq Gα49B (FlyBase, 2009-)
Source for database merge of
Additional comments	FlyBase curator comment: Genes encoding Gα subunits that have been named for their molecular function/orthology have had their symbols and names standardized following the format used in FBrf0220456, which also reflects popular usage in the Drosophila literature. (FlyBase, 2009-)
Other Comments
	Galpha49B signaling mediates odor identity discrimination in naive flies. (Xia and Tully, 2007) Excess of Gβ76C over Gα49B prevents dark, spontaneous activity of photoreceptors. (Elia et al., 2005) Gα49B is necessary for light-dependent architectural changes in the eye. (Kosloff et al., 2003) dsRNA made from templates generated with primers against this gene tested in a cl-8 cell reporter assay to examine any role of Gα49B in the hh signalling pathway. (Lum, 2003) Alternative splicing of Gα49B RNA and the distribution of the various isoforms has been analysed. (Alvarez et al., 1996) Gα49B is essential for photoreceptor cell function, and functions as a molecular switch, reporting activity upstream in the signalling pathway. (Scott et al., 1995) Gα49B mediates the stimulation by light-activated rhodopsin of the norpA-encoded phospholipase C in the visual transduction cascade. (Lee et al., 1994) Gα49B has been cloned and sequenced. (Lee et al., 1990) A Gα49B cDNA has been cloned and sequenced. (Strathmann and Simon, 1990)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_165919 NM_165920 NM_165921 NM_165922 NM_165924 NM_165925 RefSeq (Proteins) • NP_725191 NP_725192 NP_725193 NP_725194 NP_725196 NP_725197 DDBJ / EMBL / GenBank • AA439352 AA694764 AAA28460 AAC46943 AAF58485 AAG22276 AAM49880 AAM68627 AAM68628 AAM68629 AAM68630 AAM68631 AAM68632 AW941137 AW942291 AY118511 BH809573 BH809575 CZ486755 CZ486756 M58016 U31092 Entrez Gene - A searchable database of RefSeq genes. • 36384 UniProtKB/Swiss-Prot • P23625 UniProtKB/TrEMBL • A4UZE6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • G-protein alpha subunit, group Q (IPR000654) Guanine nucleotide binding protein (G-protein), alpha subunit (IPR001019) G protein alpha subunit, helical insertion (IPR011025) P-loop containing nucleoside triphosphate hydrolase (IPR027417) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • IP15229 LD13901
Linkouts
	BioGRID - A database of protein and genetic interactions • 62158 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0004435 DroID - A comprehensive database of gene and protein interactions. • FBgn0004435 DRSC - Results from RNAi screens. • FBgn0004435 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004435 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17759-RA;CG17759-RD FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004435 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36384 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36384 modMine - Data generated by the modENCODE project. • FBgn0004435
Synonyms & Secondary IDs ( 49 )
Reported As
Symbol Synonym	CG17759 (Adams, 2002, Labourier et al., 2002, Goldman and Arbeitman, 2007, Boto et al., 2010, Ni et al., 2011.7.19, Hayden and Bosco, 2008, Keleman et al., 2009.8.5, Ni et al., 2009, Khanna et al., 2010, Ni et al., 2008, Ni et al., 2010.12.1, Cammarato et al., 2011, Colicelli, 2004) dGqα (Smith, 1996, Talluri et al., 1995) dGαq (Xia and Tully, 2006) dGaα (Kalidas and Smith, 2002) dgq (Satoh and Ready, 2005, Ratnaparkhi et al., 2002, Kain et al., 2005, Hardie, 2001, Iakhine et al., 2002, Banerjee and Hasan, 2001, Zemelman et al., 2002, Iakhine et al., 2001, Kiselev et al., 2000, Lee, 1993.3.10, Wilkie, 1999, Ratnaparkhi and Hasan, 1999, Milligan et al., 1997, Alvarez et al., 1996, Zars and Hyde, 1996, Zuker, 1996, Talluri et al., 1995, Scott et al., 1995, Zars and Hyde, 1995, Lee et al., 1994, Zuker, 1992, Ranganathan et al., 1991, Lee et al., 1990, Satoh et al., 2010, Sanxaridis et al., 2007, Pinal and Pichaud, 2011, Kain et al., 2010, Banerjee et al., 2006, Cronin et al., 2004, Pumir et al., 2008, Kain et al., 2008, Kain et al., 2009) Dgq (Tsunoda et al., 2001, Vinos et al., 1997, Yarfitz et al., 1993, Yarfitz et al., 1994) DGq (Huber et al., 1999, Hasan, 1998, Running Deer et al., 1995, Hyde et al., 1991) dGq (Georgiev et al., 2005) dGqa-49b (Kalidas et al., 2001) dGqalpha-3 (Talluri, 1995.7.5) dGqα (Lee and Montell, 2004, Smith et al., 1995, Kwon et al., 2008) DGqα (Kosloff et al., 2003, Hyde et al., 1991, Strathmann and Simon, 1990) dgqα (Buchner, 1991) dGqα-49b (Smith et al., 2001) DGαq   DGαq (Hyde et al., 1993) DmGαq (Bahner et al., 2000) Dromel_CG17759_galpha49b_mORF (Hayden and Bosco, 2008) G?q (Pinal and Pichaud, 2007) Gaq (Kosloff et al., 2003) Gq (Venkatachalam et al., 2002, Voets and Nilius, 2003, Hardie, 2001, Liu et al., 2000, Hardie, 2003, Boto et al., 2010, Georgiev et al., 2005) Gqα (Hardie, 2001, Iakhine et al., 2004, Cronin et al., 2004, Frechter et al., 2007, Rosenbaum et al., 2011) Gqα (Tsunoda et al., 1997) Gαq (Knox et al., 2003, Vasiliauskas et al., 2011, Han et al., 2007, Xia and Tully, 2007, Ni et al., 2008) Gq (Delmas et al., 2004) Galpha (Ni et al., 2009) Galpha49b (Lum, 2003) G alpha 49B (Adams, 2002) Galpha49B (Reiter et al., 2001, Dorus et al., 2006, Dorus et al., 2006, Haerty et al., 2007, Hayden and Bosco, 2008, Japanese National Institute of Genetics, 2012.5.21) Gaq (Hardie et al., 2002, Pinal and Pichaud, 2007, Elia et al., 2005) Gq (Kain et al., 2005, Kwon and Montell, 2006, Boto et al., 2007, Tian et al., 2013, Boto et al., 2010, Kain et al., 2009) Gqa-3 (Zelhof et al., 2001) Gqα (Xu et al., 2004, Montell, 1999, Sanxaridis et al., 2007, Kain et al., 2010, Rosenbaum et al., 2006, Bredendiek et al., 2011, Wes et al., 1999, Rosenbaum et al., 2012) Gqα{e} (Elia et al., 2005) Gqαe (Elia et al., 2005) Gqαe (Pinal and Pichaud, 2011) Gα (Lee and Montell, 2004, Burack and Shaw, 2000, Zemelman et al., 2002, Tsunoda et al., 2001, Yamashita et al., 2005, Kopein and Katanaev, 2009) gα49B (Hilgers et al., 2011) Gα49B (Meyer et al., 2008, Shen et al., 2011, Yang et al., 2005, Bakal et al., 2007, Landry et al., 2007, McGurk et al., 2008, Kwon et al., 2008, Dorus et al., 2006, Taraszka et al., 2005) Gαq (Lee et al., 2004, Montell, 2000, Harris and Lim, 2001, Schulz et al., 1999, Wang et al., 2008, Yao and Carlson, 2010, Hu et al., 2012, Elsaesser et al., 2010) Gαq (Roman, 2004, Hardie et al., 2004, Schillo et al., 2004, Baumann, 2004, Hardie et al., 2003, Hardie et al., 2002, Suh et al., 2001, Agam et al., 2000, Cook et al., 2000, Chyb et al., 1999, Scott and Zuker, 1998, Scott et al., 1997, Banerjee and Hasan, 2005, Han et al., 2006, Elsaesser et al., 2010, Hiramoto and Hiromi, 2006, Meyer et al., 2006, Ha et al., 2009, Buchon et al., 2009, Katanayeva et al., 2010, Voolstra et al., 2010, Deng et al., 2011, Chakrabarti et al., 2012) sast (Hu et al., 2012)
Name Synonym	G protein 49B (Goldman and Arbeitman, 2007) G-protein alpha49B (Hayden and Bosco, 2008) G protein alpha49B (Khanna et al., 2010, Cammarato et al., 2011) G protein α49B   G-protein-αq   G protein α q subunit   small amplify and slow termination (Hu et al., 2012)
Secondary FlyBase IDs
	FBgn0004178
References ( 171 )
Generate a list of	All references relating to this gene ( 171 )
List References by type	Research paper  ( 99 ) Supplementary material  ( 10 ) Review  ( 19 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 19 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 2 ) Stock list  ( 1 ) Curated genome annotation  ( 3 ) Protein sequence record  ( 1 ) Website  ( 2 )
Recent research papers ( 12 )
	Tian et al., 2013, Neuron 77(2): 311--322 Neurexin Regulates Visual Function via Mediating Retinoid Transport to Promote Rhodopsin Maturation. [FBrf0220614] Chakrabarti et al., 2012, Cell Host Microbe 12(1): 60--70 Infection-induced host translational blockage inhibits immune responses and epithelial renewal in the Drosophila gut. [FBrf0218984] Hu et al., 2012, J. Biol. Chem. 287(17): 13911--13918 Protein gq modulates termination of phototransduction and prevents retinal degeneration. [FBrf0218114] Katz and Minke, 2012, J. Neurosci. 32(8): 2722--2733 Phospholipase C-mediated suppression of dark noise enables single-photon detection in Drosophila photoreceptors. [FBrf0217559] Rosenbaum et al., 2012, Vis. Neurosci. 29(3): 143--156 Drosophila GPI-mannosyltransferase 2 is required for GPI anchor attachment and surface expression of chaoptin. [FBrf0218440] Bredendiek et al., 2011, Chem. Senses 36(1): 69--81 Go α is involved in sugar perception in Drosophila. [FBrf0212580] Deng et al., 2011, PLoS ONE 6(4): e18605 The Stimulatory Gα(s) Protein Is Involved in Olfactory Signal Transduction in Drosophila. [FBrf0213437] Hilgers et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(38): 15864--15869 Neural-specific elongation of 3' UTRs during Drosophila development. [FBrf0215804] Pinal and Pichaud, 2011, J. Cell Sci. 124(9): 1564--1570 Dynamin- and Rab5-dependent endocytosis is required to prevent Drosophila photoreceptor degeneration. [FBrf0213465] Rosenbaum et al., 2011, Neuron 72(4): 602--615 XPORT-Dependent Transport of TRP and Rhodopsin. [FBrf0216705] Shen et al., 2011, Science 331(6022): 1333--1336 Function of rhodopsin in temperature discrimination in Drosophila. [FBrf0213227] Vasiliauskas et al., 2011, Nature 479(7371): 108--112 Feedback from rhodopsin controls rhodopsin exclusion in Drosophila photoreceptors. [FBrf0216554] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...