dgq, Gqα, Gα49B, Galpha49B, Gq
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Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Stage-specific extension of 3' UTRs observed during embryogenesis (FBrf0215804); all variants may not be annotated.
5' UTR contains an ORF described as a putative conserved uORF (FBrf0204849); potential peptide 31aa in length.
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.46
gene_with_dicistronic_mRNA ; SO:0000722
Gene model reviewed during 5.54
3.549 (longest cDNA)
1.8 (northern blot)
353 (aa)
317 (aa); 41.3, 37.2 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gαq using the Feature Mapper tool.
Comment: maternally deposited
Comment: extended 3' UTR isoform
Comment: all isoforms
Comment: all isoforms except Gq-RD (Gα49B-RD)
Comment: all isoforms except Gq-RD (Gα49B-RD)
Zygotic-specific isoforms of Gαq with long 3' UTR extensions were observed.
Eye-enriched transcripts determined by ratio of expression level in wild-type heads. versus expression level in so heads.
Gα49B protein is localized to the photoreceptor cells of the retina. It is also detected in the lamina and the medulla, presumably in axons of the photoreceptor cells that project to these optic ganglia.
In adult head sections, this Gα49B protein isoform localizes to the third antennal segment, the maxillary palps, the tip of the proboscis, and the lamina. A subset of the staining detected in the third antennal segment localizes to olfactory neurons.
Gα49B proteins are detected in all rhabdomeres of the eye, and in ocelli.
GBrowse - Visual display of RNA-Seq signals
View Dmel\Gαq in GBrowse 22-67
2-67
2-69.7
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Gα49B CG17759
Source for identity of: Gαq Gα49B
FlyBase curator comment: Genes encoding Gα subunits that have been named for their molecular function/orthology have had their symbols and names standardized following the format used in FBrf0220456, which also reflects popular usage in the Drosophila literature.
Galpha49B signaling mediates odor identity discrimination in naive flies.
Gα49B is necessary for light-dependent architectural changes in the eye.
Alternative splicing of Gα49B RNA and the distribution of the various isoforms has been analysed.
Gα49B is essential for photoreceptor cell function, and functions as a molecular switch, reporting activity upstream in the signalling pathway.
Gα49B has been cloned and sequenced.
A Gα49B cDNA has been cloned and sequenced.