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Gene Dmel\UbcD6

General Information
Symbol	Dmel\UbcD6	Species	D. melanogaster
Name	Ubiquitin conjugating enzyme	Annotation symbol	CG2013
Feature type	protein_coding_gene	FlyBase ID	FBgn0004436
Gene Model Status	Current	Stock availability	11 publicly available
Also Known As	Dhr6, RAD6
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	82E3-82E4	Sequence location	3R:774,477..778,404 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ubiquitin conjugating enzyme is referred to in FlyBase by the symbol Dmel\UbcD6 (CG2013, FBgn0004436). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ubiquitin-protein ligase activity. There is experimental evidence that it is involved in the biological process: centrosome organization; centrosome separation; DNA repair; mitotic spindle organization. 12 alleles are reported. The phenotype of these alleles is annotated with: wing. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Ubiquitin-conjugating enzyme, E2; Ubiquitin-conjugating enzyme, active site; Ubiquitin-conjugating enzyme/RWD-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 12-24 hour embryonic stages, during late larval stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval Malpighian tubules, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system. Comments on Affy2 ProbeSet: ProbeSet 1630287_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of UbcD6. Gene sequence location is 3R:774477..778404.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 82E3-82E4   Limits computationally determined from genome sequence between P{PZ}l(3)0273302733 and P{EP}EP974
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\UbcD6 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.39 Gene model reviewed during 5.47 Low-frequency RNA-Seq exon junction(s) not annotated. Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) UbcD6-RA FBtr0078849  NM_079506   2166   151 UbcD6-RB FBtr0301663  NM_001170037   2023   118 UbcD6-RC FBtr0306106  NM_001259987   1144   151 UbcD6-RE FBtr0335207  NM_001259988   960   139
Additional Transcript Data & Comments
Reported size (kB)	2.1, 1.3 (northern blot) (Koken et al., 1991)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein UbcD6-PA   FBpp0078490   17.2   151   5.78     NP_524230   AAF52079 UbcD6-PB   FBpp0290877   13.4   118   4.83     NP_001163508   ACZ94807 UbcD6-PC   FBpp0297243   17.2   151   5.78     NP_001246916   AFH06235 UbcD6-PE   FBpp0307194   15.6   139   4.56     NP_001246917   AFH06236
Additional Polypeptide Data & Comments
Reported size (kDa)	151 (aa); 17 (kD predicted) (Koken et al., 1991)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ubiquitin-conjugating enzyme, E2 (IPR000608) Ubiquitin-conjugating enzyme/RWD-like (IPR016135) Ubiquitin-conjugating enzyme, active site (IPR023313)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA695215   AA817430   AE014297 AAF52079   AE014297 ACZ94807   AE014297 AFH06235   AE014297 AFH06236   AI455302   AX093930   AY069216   BG633590   BG636548   BI163694   BI214465   BI215366   BI232141   BI236717   BI237480   BI241274   BI356412   BI358732   BI363251   BI364278   BI365074   BI365861   BI366060   BI372016   BI482927   BI640237   BI640747   BI640867   BP542897   BP542898   BP546511   BP560019   BP560020   BT003481 AAO39484   BT124994   CA804337   CK133305   CK661704   CO155959   CO180630   CO180673   CO184781   CO185831   CO186023   CO188740   CO264531   CO265987   CO266057   CO266534   CO267237   CO271396   CO274963   CO276713   CO282265   CO286352   CO292217   CO294877   CO297903   CO307631   CO308202   CO308662   CO308911   CO311557   CO313148   CO316236   CO316893   CO331838   CO338953   CZ472517   CZ472518   CZ479281   DN154405   EC057765   EC063943   EC066302   EC068673   EC072982   EC073521   EC088161   EC088556   EC195196   EC197597   EC199068   EC202627   EC203785   EC205193   EC206109   EC206213   EC206220   EC211255   EC215145   EC220283   EC222618   EC223073   EC225270   EC225812   EC227211   EC227579   EC229486   EC233628   EC238061   EC241893   EC244826   EC251330   EC257783   EC267562   M63791 AAA28309   M63792 AAA28308   M64435 AAA28309
UniProtKB/Swiss-Prot	P25153
UniProtKB/TrEMBL	E1JJ49
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval Malpighian tubules, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    188.275 Larval Midgut    237.7 Larval Hindgut    317.4 Larval Malpighian Tubules    611.2 Larval Fat Body    354.9 Larval Salivary Gland    449.3 Larval Trachea    283.1 Larval Carcass    640.3 Adult Head    336.4 Adult Eye    476.75 Adult Brain    343 Adult Thoracic-Abdominal Ganglion    262.9 Adult Crop    451.3 Adult Midgut    384.1 Adult Hindgut    336.9 Adult Malpighian Tubules    164.5 Adult Fat Body    279.7 Adult Salivary Gland    227 Adult Heart    329.85 Adult VirginFemale Spermatheca    139.7 Adult InseminatedFemale Spermatheca    125.1 Adult Ovary    483.3 Adult Testis    357.7 Adult Male Accessory Gland    369.3 Adult Carcass    501.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    188.275 Larval Midgut    237.7 Larval Hindgut    317.4 Larval Malpighian Tubules  (611.2) Larval Fat Body    354.9 Larval Salivary Gland    449.3 Larval Trachea    283.1 Larval Carcass  (640.3) Adult Head    336.4 Adult Eye    476.75 Adult Brain    343 Adult Thoracic-Abdominal Ganglion    262.9 Adult Crop    451.3 Adult Midgut    384.1 Adult Hindgut    336.9 Adult Malpighian Tubules    164.5 Adult Fat Body    279.7 Adult Salivary Gland    227 Adult Heart    329.85 Adult VirginFemale Spermatheca    139.7 Adult InseminatedFemale Spermatheca    125.1 Adult Ovary    483.3 Adult Testis    357.7 Adult Male Accessory Gland    369.3 Adult Carcass  501.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    188.275 Larval Midgut    237.7 Larval Hindgut    317.4 Larval Malpighian Tubules    611.2 Larval Fat Body    354.9 Larval Salivary Gland    449.3 Larval Trachea    283.1 Larval Carcass    640.3 Adult Head    336.4 Adult Eye    476.75 Adult Brain    343 Adult Thoracic-Abdominal Ganglion    262.9 Adult Crop    451.3 Adult Midgut    384.1 Adult Hindgut    336.9 Adult Malpighian Tubules    164.5 Adult Fat Body    279.7 Adult Salivary Gland    227 Adult Heart    329.85 Adult VirginFemale Spermatheca    139.7 Adult InseminatedFemale Spermatheca    125.1 Adult Ovary    483.3 Adult Testis    357.7 Adult Male Accessory Gland    369.3 Adult Carcass    501.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    188.275 Larval Midgut    237.7 Larval Hindgut    317.4 Larval Malpighian Tubules    611.2 Larval Fat Body    354.9 Larval Salivary Gland    449.3 Larval Trachea    283.1 Larval Carcass    640.3 Adult Head    336.4 Adult Eye    476.75 Adult Brain    343 Adult Thoracic-Abdominal Ganglion    262.9 Adult Crop    451.3 Adult Midgut    384.1 Adult Hindgut    336.9 Adult Malpighian Tubules    164.5 Adult Fat Body    279.7 Adult Salivary Gland    227 Adult Heart    329.85 Adult VirginFemale Spermatheca    139.7 Adult InseminatedFemale Spermatheca    125.1 Adult Ovary    483.3 Adult Testis    357.7 Adult Male Accessory Gland    369.3 Adult Carcass    501.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    188.275 Larval Midgut    237.7 Larval Hindgut    317.4 Larval Malpighian Tubules    611.2 Larval Fat Body    354.9 Larval Salivary Gland    449.3 Larval Trachea    283.1 Larval Carcass    640.3 Adult Head    336.4 Adult Eye    476.75 Adult Brain    343 Adult Thoracic-Abdominal Ganglion    262.9 Adult Crop    451.3 Adult Midgut    384.1 Adult Hindgut    336.9 Adult Malpighian Tubules    164.5 Adult Fat Body    279.7 Adult Salivary Gland    227 Adult Heart    329.85 Adult VirginFemale Spermatheca    139.7 Adult InseminatedFemale Spermatheca    125.1 Adult Ovary    483.3 Adult Testis    357.7 Adult Male Accessory Gland    369.3 Adult Carcass    501.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    188.275 Larval Midgut    237.7 Larval Hindgut    317.4 Larval Malpighian Tubules  611.2 Larval Fat Body    354.9 Larval Salivary Gland    449.3 Larval Trachea    283.1 Larval Carcass  640.3 Adult Head    336.4 Adult Eye    476.75 Adult Brain    343 Adult Thoracic-Abdominal Ganglion    262.9 Adult Crop    451.3 Adult Midgut    384.1 Adult Hindgut    336.9 Adult Malpighian Tubules    164.5 Adult Fat Body    279.7 Adult Salivary Gland    227 Adult Heart    329.85 Adult VirginFemale Spermatheca    139.7 Adult InseminatedFemale Spermatheca    125.1 Adult Ovary    483.3 Adult Testis    357.7 Adult Male Accessory Gland    369.3 Adult Carcass  501.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    188.275 Larval Midgut    237.7 Larval Hindgut    317.4 Larval Malpighian Tubules    611.2 Larval Fat Body    354.9 Larval Salivary Gland    449.3 Larval Trachea    283.1 Larval Carcass    640.3 Adult Head    336.4 Adult Eye    476.75 Adult Brain    343 Adult Thoracic-Abdominal Ganglion    262.9 Adult Crop    451.3 Adult Midgut    384.1 Adult Hindgut    336.9 Adult Malpighian Tubules    164.5 Adult Fat Body    279.7 Adult Salivary Gland    227 Adult Heart    329.85 Adult VirginFemale Spermatheca    139.7 Adult InseminatedFemale Spermatheca    125.1 Adult Ovary    483.3 Adult Testis    357.7 Adult Male Accessory Gland    369.3 Adult Carcass    501.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    188.275 Larval Midgut    237.7 Larval Hindgut    317.4 Larval Malpighian Tubules    611.2 Larval Fat Body    354.9 Larval Salivary Gland    449.3 Larval Trachea    283.1 Larval Carcass    640.3 Adult Head    336.4 Adult Eye    476.75 Adult Brain    343 Adult Thoracic-Abdominal Ganglion    262.9 Adult Crop    451.3 Adult Midgut    384.1 Adult Hindgut    336.9 Adult Malpighian Tubules    164.5 Adult Fat Body    279.7 Adult Salivary Gland    227 Adult Heart    329.85 Adult VirginFemale Spermatheca    139.7 Adult InseminatedFemale Spermatheca    125.1 Adult Ovary    483.3 Adult Testis    357.7 Adult Male Accessory Gland    369.3 Adult Carcass    501.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    336.4   NA  Eye    476.75   NA  Brain    343   188.275  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    262.9   NA  Crop    451.3   237.7  Midgut    384.1   317.4  Hindgut    336.9   611.2  Malpighian Tubules    164.5   354.9  Fat Body    279.7   449.3  Salivary Gland    227   NA  Heart    329.85   283.1  Trachea    NA   NA  VirginFemale Spermatheca    139.7   NA  InseminatedFemale Spermatheca    125.1   NA  Ovary    483.3   NA  Testis    357.7   NA  Male Accessory Gland    369.3   640.3  Carcass    501.9 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    26 central nervous system, larvae L3    35 central nervous system, pupae P8    47 head, virgin 1-day female    32 head, virgin 4-day female    28 head, virgin 20-day female    21 head, mated 1-day female    29 head, mated 4-day female    22 head, mated 20-day female    19 head, mated 1-day male    42 head, mated 4-day male    35 head, mated 20-day male    30 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    24 digestive system, larvae L3 wandering    33 digestive system, 1-day adult    20 digestive system, 4-day adult    17 digestive system, 20-day adult    16 fat body, larvae L3 wandering    9 fat body, white prepupae    22 fat body, pupae P8    25 carcass, larvae L3 wandering    40 carcass, 1-day adult    33 carcass, 4-day adult    25 carcass, 20-day adult    23 ovary, virgin 4-day female    31 ovary, mated 4-day female    24 testis, mated 4-day male    11 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  26 central nervous system, larvae L3  (35) central nervous system, pupae P8  (47) head, virgin 1-day female  (32) head, virgin 4-day female  (28) head, virgin 20-day female    21 head, mated 1-day female  (29) head, mated 4-day female    22 head, mated 20-day female    19 head, mated 1-day male  (42) head, mated 4-day male  (35) head, mated 20-day male  (30) salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    24 digestive system, larvae L3 wandering  (33) digestive system, 1-day adult    20 digestive system, 4-day adult    17 digestive system, 20-day adult    16 fat body, larvae L3 wandering    9 fat body, white prepupae    22 fat body, pupae P8    25 carcass, larvae L3 wandering  (40) carcass, 1-day adult  (33) carcass, 4-day adult    25 carcass, 20-day adult    23 ovary, virgin 4-day female  (31) ovary, mated 4-day female    24 testis, mated 4-day male    11 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    26 central nervous system, larvae L3    35 central nervous system, pupae P8    47 head, virgin 1-day female    32 head, virgin 4-day female    28 head, virgin 20-day female    21 head, mated 1-day female    29 head, mated 4-day female    22 head, mated 20-day female    19 head, mated 1-day male    42 head, mated 4-day male    35 head, mated 20-day male    30 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    24 digestive system, larvae L3 wandering    33 digestive system, 1-day adult    20 digestive system, 4-day adult    17 digestive system, 20-day adult    16 fat body, larvae L3 wandering    9 fat body, white prepupae    22 fat body, pupae P8    25 carcass, larvae L3 wandering    40 carcass, 1-day adult    33 carcass, 4-day adult    25 carcass, 20-day adult    23 ovary, virgin 4-day female    31 ovary, mated 4-day female    24 testis, mated 4-day male    11 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    26 central nervous system, larvae L3    35 central nervous system, pupae P8    47 head, virgin 1-day female    32 head, virgin 4-day female    28 head, virgin 20-day female    21 head, mated 1-day female    29 head, mated 4-day female    22 head, mated 20-day female    19 head, mated 1-day male    42 head, mated 4-day male    35 head, mated 20-day male    30 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    24 digestive system, larvae L3 wandering    33 digestive system, 1-day adult    20 digestive system, 4-day adult    17 digestive system, 20-day adult    16 fat body, larvae L3 wandering    9 fat body, white prepupae    22 fat body, pupae P8    25 carcass, larvae L3 wandering    40 carcass, 1-day adult    33 carcass, 4-day adult    25 carcass, 20-day adult    23 ovary, virgin 4-day female    31 ovary, mated 4-day female    24 testis, mated 4-day male    11 accessory gland, mated 4-day male    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    26 central nervous system, larvae L3    35 central nervous system, pupae P8    47 head, virgin 1-day female    32 head, virgin 4-day female    28 head, virgin 20-day female    21 head, mated 1-day female    29 head, mated 4-day female    22 head, mated 20-day female    19 head, mated 1-day male    42 head, mated 4-day male    35 head, mated 20-day male    30 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    24 digestive system, larvae L3 wandering    33 digestive system, 1-day adult    20 digestive system, 4-day adult    17 digestive system, 20-day adult    16 fat body, larvae L3 wandering    9 fat body, white prepupae    22 fat body, pupae P8    25 carcass, larvae L3 wandering    40 carcass, 1-day adult    33 carcass, 4-day adult    25 carcass, 20-day adult    23 ovary, virgin 4-day female    31 ovary, mated 4-day female    24 testis, mated 4-day male    11 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  26 central nervous system, larvae L3  (35) central nervous system, pupae P8  (47) head, virgin 1-day female  32 head, virgin 4-day female  28 head, virgin 20-day female    21 head, mated 1-day female  29 head, mated 4-day female    22 head, mated 20-day female    19 head, mated 1-day male  (42) head, mated 4-day male  (35) head, mated 20-day male  30 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    24 digestive system, larvae L3 wandering  (33) digestive system, 1-day adult    20 digestive system, 4-day adult    17 digestive system, 20-day adult    16 fat body, larvae L3 wandering    9 fat body, white prepupae    22 fat body, pupae P8    25 carcass, larvae L3 wandering  (40) carcass, 1-day adult  (33) carcass, 4-day adult    25 carcass, 20-day adult    23 ovary, virgin 4-day female  31 ovary, mated 4-day female    24 testis, mated 4-day male    11 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    26 central nervous system, larvae L3    35 central nervous system, pupae P8    47 head, virgin 1-day female    32 head, virgin 4-day female    28 head, virgin 20-day female    21 head, mated 1-day female    29 head, mated 4-day female    22 head, mated 20-day female    19 head, mated 1-day male    42 head, mated 4-day male    35 head, mated 20-day male    30 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    24 digestive system, larvae L3 wandering    33 digestive system, 1-day adult    20 digestive system, 4-day adult    17 digestive system, 20-day adult    16 fat body, larvae L3 wandering    9 fat body, white prepupae    22 fat body, pupae P8    25 carcass, larvae L3 wandering    40 carcass, 1-day adult    33 carcass, 4-day adult    25 carcass, 20-day adult    23 ovary, virgin 4-day female    31 ovary, mated 4-day female    24 testis, mated 4-day male    11 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    26 central nervous system, larvae L3    35 central nervous system, pupae P8    47 head, virgin 1-day female    32 head, virgin 4-day female    28 head, virgin 20-day female    21 head, mated 1-day female    29 head, mated 4-day female    22 head, mated 20-day female    19 head, mated 1-day male    42 head, mated 4-day male    35 head, mated 20-day male    30 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    24 digestive system, larvae L3 wandering    33 digestive system, 1-day adult    20 digestive system, 4-day adult    17 digestive system, 20-day adult    16 fat body, larvae L3 wandering    9 fat body, white prepupae    22 fat body, pupae P8    25 carcass, larvae L3 wandering    40 carcass, 1-day adult    33 carcass, 4-day adult    25 carcass, 20-day adult    23 ovary, virgin 4-day female    31 ovary, mated 4-day female    24 testis, mated 4-day male    11 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 12-24 hour embryonic stages, during late larval stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    32 embryo 02-04hr    36 embryo 04-06hr    22 embryo 06-08hr    30 embryo 08-10hr    38 embryo 10-12hr    31 embryo 12-14hr    54 embryo 14-16hr    21 embryo 16-18hr    46 embryo 18-20hr    38 embryo 20-22hr    37 embryo 22-24hr    60 larva L1    22 larva L2    31 larva L3 12hr old    24 larva L3 puffstage 1-2    35 larva L3 puffstage 3-6    48 larva L3 puffstage 7-9    68 white prepupae new    64 white prepupae 12hr    41 white prepupae 24hr    41 pupae 2d postWPP    53 pupae 3d postWPP    38 pupae 4d postWPP    28 adult male 01day    38 adult male 05day    33 adult male 30day    19 adult female 01day    20 adult female 05day    33 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (32) embryo 02-04hr  (36) embryo 04-06hr    22 embryo 06-08hr  (30) embryo 08-10hr  (38) embryo 10-12hr  (31) embryo 12-14hr  (54) embryo 14-16hr    21 embryo 16-18hr  (46) embryo 18-20hr  (38) embryo 20-22hr  (37) embryo 22-24hr  (60) larva L1    22 larva L2  (31) larva L3 12hr old    24 larva L3 puffstage 1-2  (35) larva L3 puffstage 3-6  (48) larva L3 puffstage 7-9  (68) white prepupae new  (64) white prepupae 12hr  (41) white prepupae 24hr  (41) pupae 2d postWPP  (53) pupae 3d postWPP  (38) pupae 4d postWPP  (28) adult male 01day  (38) adult male 05day  (33) adult male 30day    19 adult female 01day    20 adult female 05day  (33) adult female 30day  (29) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    32 embryo 02-04hr    36 embryo 04-06hr    22 embryo 06-08hr    30 embryo 08-10hr    38 embryo 10-12hr    31 embryo 12-14hr    54 embryo 14-16hr    21 embryo 16-18hr    46 embryo 18-20hr    38 embryo 20-22hr    37 embryo 22-24hr    60 larva L1    22 larva L2    31 larva L3 12hr old    24 larva L3 puffstage 1-2    35 larva L3 puffstage 3-6    48 larva L3 puffstage 7-9    68 white prepupae new    64 white prepupae 12hr    41 white prepupae 24hr    41 pupae 2d postWPP    53 pupae 3d postWPP    38 pupae 4d postWPP    28 adult male 01day    38 adult male 05day    33 adult male 30day    19 adult female 01day    20 adult female 05day    33 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    32 embryo 02-04hr    36 embryo 04-06hr    22 embryo 06-08hr    30 embryo 08-10hr    38 embryo 10-12hr    31 embryo 12-14hr    54 embryo 14-16hr    21 embryo 16-18hr    46 embryo 18-20hr    38 embryo 20-22hr    37 embryo 22-24hr    60 larva L1    22 larva L2    31 larva L3 12hr old    24 larva L3 puffstage 1-2    35 larva L3 puffstage 3-6    48 larva L3 puffstage 7-9    68 white prepupae new    64 white prepupae 12hr    41 white prepupae 24hr    41 pupae 2d postWPP    53 pupae 3d postWPP    38 pupae 4d postWPP    28 adult male 01day    38 adult male 05day    33 adult male 30day    19 adult female 01day    20 adult female 05day    33 adult female 30day    29 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    32 embryo 02-04hr    36 embryo 04-06hr    22 embryo 06-08hr    30 embryo 08-10hr    38 embryo 10-12hr    31 embryo 12-14hr    54 embryo 14-16hr    21 embryo 16-18hr    46 embryo 18-20hr    38 embryo 20-22hr    37 embryo 22-24hr    60 larva L1    22 larva L2    31 larva L3 12hr old    24 larva L3 puffstage 1-2    35 larva L3 puffstage 3-6    48 larva L3 puffstage 7-9    68 white prepupae new    64 white prepupae 12hr    41 white prepupae 24hr    41 pupae 2d postWPP    53 pupae 3d postWPP    38 pupae 4d postWPP    28 adult male 01day    38 adult male 05day    33 adult male 30day    19 adult female 01day    20 adult female 05day    33 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  32 embryo 02-04hr  (36) embryo 04-06hr    22 embryo 06-08hr  30 embryo 08-10hr  (38) embryo 10-12hr  31 embryo 12-14hr  (54) embryo 14-16hr    21 embryo 16-18hr  (46) embryo 18-20hr  (38) embryo 20-22hr  (37) embryo 22-24hr  (60) larva L1    22 larva L2  31 larva L3 12hr old    24 larva L3 puffstage 1-2  (35) larva L3 puffstage 3-6  (48) larva L3 puffstage 7-9  (68) white prepupae new  (64) white prepupae 12hr  (41) white prepupae 24hr  (41) pupae 2d postWPP  (53) pupae 3d postWPP  (38) pupae 4d postWPP  28 adult male 01day  (38) adult male 05day  (33) adult male 30day    19 adult female 01day    20 adult female 05day  (33) adult female 30day  29 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    32 embryo 02-04hr    36 embryo 04-06hr    22 embryo 06-08hr    30 embryo 08-10hr    38 embryo 10-12hr    31 embryo 12-14hr    54 embryo 14-16hr    21 embryo 16-18hr    46 embryo 18-20hr    38 embryo 20-22hr    37 embryo 22-24hr    60 larva L1    22 larva L2    31 larva L3 12hr old    24 larva L3 puffstage 1-2    35 larva L3 puffstage 3-6    48 larva L3 puffstage 7-9    68 white prepupae new    64 white prepupae 12hr    41 white prepupae 24hr    41 pupae 2d postWPP    53 pupae 3d postWPP    38 pupae 4d postWPP    28 adult male 01day    38 adult male 05day    33 adult male 30day    19 adult female 01day    20 adult female 05day    33 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    32 embryo 02-04hr    36 embryo 04-06hr    22 embryo 06-08hr    30 embryo 08-10hr    38 embryo 10-12hr    31 embryo 12-14hr    54 embryo 14-16hr    21 embryo 16-18hr    46 embryo 18-20hr    38 embryo 20-22hr    37 embryo 22-24hr    60 larva L1    22 larva L2    31 larva L3 12hr old    24 larva L3 puffstage 1-2    35 larva L3 puffstage 3-6    48 larva L3 puffstage 7-9    68 white prepupae new    64 white prepupae 12hr    41 white prepupae 24hr    41 pupae 2d postWPP    53 pupae 3d postWPP    38 pupae 4d postWPP    28 adult male 01day    38 adult male 05day    33 adult male 30day    19 adult female 01day    20 adult female 05day    33 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    60 Schneider line 2 Sg4    16 embryonic 1182-4H    31 embryonic GM2    58 embryonic Kc167    71 embryonic S1    36 embryonic S3    38 leg disc CME L1    17 wing disc CME-W2    57 wing disc ML-DmD8    41 wing disc ML-DmD9    28 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    8 wing disc ML-DmD32    31 haltere disc ML-DmD17-c3    38 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    38 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    32 CNS ML-DmBG2-c2    67 tumorous blood cells mbn2    106 ovary fGS/OSS    23 ovary OSC    29 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (60) Schneider line 2 Sg4    16 embryonic 1182-4H  (31) embryonic GM2  (58) embryonic Kc167  (71) embryonic S1  (36) embryonic S3  (38) leg disc CME L1    17 wing disc CME-W2  (57) wing disc ML-DmD8  (41) wing disc ML-DmD9  (28) wing disc ML-DmD16-c3    24 wing disc ML-DmD21    8 wing disc ML-DmD32  (31) haltere disc ML-DmD17-c3  (38) eye-antennal disc ML-DmD11  (28) antennal disc ML-DmD20-c5  (38) mixed discs ML-DmD4-c1  (28) CNS ML-DmBG1-c1  (32) CNS ML-DmBG2-c2  (67) tumorous blood cells mbn2  (106) ovary fGS/OSS    23 ovary OSC  (29) ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    60 Schneider line 2 Sg4    16 embryonic 1182-4H    31 embryonic GM2    58 embryonic Kc167    71 embryonic S1    36 embryonic S3    38 leg disc CME L1    17 wing disc CME-W2    57 wing disc ML-DmD8    41 wing disc ML-DmD9    28 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    8 wing disc ML-DmD32    31 haltere disc ML-DmD17-c3    38 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    38 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    32 CNS ML-DmBG2-c2    67 tumorous blood cells mbn2  106 ovary fGS/OSS    23 ovary OSC    29 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    60 Schneider line 2 Sg4    16 embryonic 1182-4H    31 embryonic GM2    58 embryonic Kc167    71 embryonic S1    36 embryonic S3    38 leg disc CME L1    17 wing disc CME-W2    57 wing disc ML-DmD8    41 wing disc ML-DmD9    28 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    8 wing disc ML-DmD32    31 haltere disc ML-DmD17-c3    38 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    38 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    32 CNS ML-DmBG2-c2    67 tumorous blood cells mbn2    106 ovary fGS/OSS    23 ovary OSC    29 ovary OSS    15 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    60 Schneider line 2 Sg4    16 embryonic 1182-4H    31 embryonic GM2    58 embryonic Kc167    71 embryonic S1    36 embryonic S3    38 leg disc CME L1    17 wing disc CME-W2    57 wing disc ML-DmD8    41 wing disc ML-DmD9    28 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    8 wing disc ML-DmD32    31 haltere disc ML-DmD17-c3    38 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    38 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    32 CNS ML-DmBG2-c2    67 tumorous blood cells mbn2    106 ovary fGS/OSS    23 ovary OSC    29 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (60) Schneider line 2 Sg4    16 embryonic 1182-4H  31 embryonic GM2  (58) embryonic Kc167  (71) embryonic S1  (36) embryonic S3  (38) leg disc CME L1    17 wing disc CME-W2  (57) wing disc ML-DmD8  (41) wing disc ML-DmD9  28 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    8 wing disc ML-DmD32  31 haltere disc ML-DmD17-c3  (38) eye-antennal disc ML-DmD11  28 antennal disc ML-DmD20-c5  (38) mixed discs ML-DmD4-c1  28 CNS ML-DmBG1-c1  32 CNS ML-DmBG2-c2  (67) tumorous blood cells mbn2  (106) ovary fGS/OSS    23 ovary OSC  29 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    60 Schneider line 2 Sg4    16 embryonic 1182-4H    31 embryonic GM2    58 embryonic Kc167    71 embryonic S1    36 embryonic S3    38 leg disc CME L1    17 wing disc CME-W2    57 wing disc ML-DmD8    41 wing disc ML-DmD9    28 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    8 wing disc ML-DmD32    31 haltere disc ML-DmD17-c3    38 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    38 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    32 CNS ML-DmBG2-c2    67 tumorous blood cells mbn2  106 ovary fGS/OSS    23 ovary OSC    29 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    60 Schneider line 2 Sg4    16 embryonic 1182-4H    31 embryonic GM2    58 embryonic Kc167    71 embryonic S1    36 embryonic S3    38 leg disc CME L1    17 wing disc CME-W2    57 wing disc ML-DmD8    41 wing disc ML-DmD9    28 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    8 wing disc ML-DmD32    31 haltere disc ML-DmD17-c3    38 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    38 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    32 CNS ML-DmBG2-c2    67 tumorous blood cells mbn2    106 ovary fGS/OSS    23 ovary OSC    29 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    9 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    41 Cadmium 50 mM 48 hrs, 4-day adult    26 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    36 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    38 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    33 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    35 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    34 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    32 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    28 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    9 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3  (41) Cadmium 50 mM 48 hrs, 4-day adult  26 Cadmium 100 mM 48 hrs, 4-day adult  (38) Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult  (36) Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult  (38) Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3  (33) Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3  (35) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (34) Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult  (32) Paraquat 10 mM 48 hrs, 4-day adult  (31) Rotenone 2 μg 12 hrs, larvae L3  (28) Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    9 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    41 Cadmium 50 mM 48 hrs, 4-day adult    26 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    36 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    38 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    33 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    35 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    34 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    32 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    28 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    9 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    41 Cadmium 50 mM 48 hrs, 4-day adult    26 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    36 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    38 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    33 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    35 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    34 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    32 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    28 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    9 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    41 Cadmium 50 mM 48 hrs, 4-day adult    26 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    36 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    38 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    33 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    35 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    34 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    32 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    28 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    9 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3  (41) Cadmium 50 mM 48 hrs, 4-day adult  26 Cadmium 100 mM 48 hrs, 4-day adult  (38) Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult  (36) Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult  (38) Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3  (33) Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3  (35) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (34) Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult  32 Paraquat 10 mM 48 hrs, 4-day adult  31 Rotenone 2 μg 12 hrs, larvae L3  28 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    9 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    41 Cadmium 50 mM 48 hrs, 4-day adult    26 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    36 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    38 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    33 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    35 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    34 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    32 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    28 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    9 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    41 Cadmium 50 mM 48 hrs, 4-day adult    26 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    36 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    38 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    33 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    35 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    34 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    32 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    28 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_25
External Data & Images
Linkouts	BDGP expression data • GH26355 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004436 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2013-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage, with Scer\GAL4Act5C.PI UbcD6dsRNA.Scer\UAS lethal | pupal stage, with Scer\GAL4pnr-MD237 UbcD6GD13294 UbcD6GD17232 partially lethal - majority die | larval stage, with Scer\GAL4Act5C.PI UbcD6dsRNA.Scer\UAS Other Phenotypes Allele increased cell death, with Scer\GAL4en.PU UbcD6dsRNA.Scer\UAS Phenotype manifest in Allele wing, with Scer\GAL4en.PU UbcD6dsRNA.Scer\UAS
Classical Alleles ( 7 )
For All Classical Alleles Show
Allele of UbcD6 Class Mutagen Stocks Known lesion UbcD6CB-5152-3 1 -- UbcD6d01923 P-element activity 1 -- UbcD6e01465 piggyBac transposase 1 -- UbcD6EY04634 P-element activity 1 -- UbcD6MB00268 1 -- UbcD6MI02360 1 -- UbcD65-HA-1292 0 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of UbcD6 Class Mutagen Stocks Known lesion UbcD6GD13294 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes UbcD6GD17232 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes UbcD6GL00405 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes UbcD6HMS02466 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes UbcD6dsRNA.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD13294} NA P{GD17232} NA P{TRiP.GL00405} NA P{TRiP.HMS02466} NA P{UAS-UBcD6.RNAi} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}snRNA:U1:82EbEY04087 NA P{EPgy2}UbcD6EY04634 NA P{XP}UbcD6d01923 NA miscellaneous insertions Mi{MIC}UbcD6MI02360 NA P{RS3}UbcD6CB-5152-3 NA P{RS5}UbcD65-HA-1292 NA P{SUPor-P}KG05726 NA PBac{RB}UbcD6e01465 NA insertion of enhancer trap binary system Mi{ET1}UbcD6MB00268 No
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
centrosome organization inferred from mutant phenotype (Goshima et al., 2007) centrosome separation inferred from mutant phenotype (Dobbelaere et al., 2008) DNA repair inferred from genetic interaction with Saccharomyces RAD6 (Koken et al., 1991) mitotic spindle organization inferred from mutant phenotype (Goshima et al., 2007)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
ubiquitin-protein ligase activity inferred from sequence or structural similarity with EMBL:AF089812 (FlyBase, 1992-) inferred from sequence or structural similarity with Saccharomyces RAD6 (Koken et al., 1991) non-traceable author statement (Swiss-Prot Project Members, 1992.5.1)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (Swiss-Prot Project Members, 1992.5.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
UbcD6 - Uba1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions UbcD6 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0004436 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40610 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P25153
Orthologs
OrthoDB Orthologs (46) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6HT9CR Dipteran inclusive ortholog search EOG6MPJ0F Insect inclusive ortholog search EOG6VQ8KS Arthropod inclusive ortholog search EOG6PVMG3 Metazoa inclusive ortholog search EOG6ZD60J
Orthologs in Drosophila Species (EOG6HT9CR)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\UbcD6     Drosophila simulans   Dsim\GD19645 Y   Drosophila sechellia   Dsec\GM10669 Y   Drosophila erecta   Dere\GG11277 Y   Drosophila yakuba   Dyak\GE25319 Y   Drosophila ananassae   Dana\GF16080 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA15184 Y   Drosophila persimilis   Dper\GL22213 Y   Drosophila willistoni   Dwil\GK14053 Y   Drosophila virilis   Dvir\GJ10109 Y   Drosophila mojavensis   Dmoj\GI22506 Y   Drosophila grimshawi   Dgri\GH15302 Y
Orthologs in non-Drosophila Dipterans (EOG6MPJ0F)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL002118   Anopheles gambiae Malaria mosquito  Agam\AGAP003857   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ004272
Orthologs in non-Dipteran Insects (EOG6VQ8KS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\UbcD6   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG010847   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH19468   Atta cephalotes Leafcutter ant  Acep\ACEP16350   Camponotus floridanus Florida carpenter ant  Cflo\CFLO14753   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL23739   Linepithema humile Argentine ant  Lhum\LH23571   Pogonomyrmex barbatus Red harvester ant  Pbar\PB24233   Solenopsis invicta Red fire ant  Sinv\SINV14995   Acyrthosiphon pisum Pea aphid  Apim\ACYPI008004   Acyrthosiphon pisum Pea aphid  Apim\ACYPI008318   Bombyx mori Silkmoth  Bmor\BGIBMGA010222   Pediculus humanus Human body louse  Phum\PHUM599030   Tribolium castaneum Red flour beetle  Tcas\TC011188
Orthologs in non-Insect Arthropods (EOG6PVMG3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_299959   Ixodes scapularis Deer tick  Isca\ISCW009979
Orthologs in non-Arthropod Metazoa (EOG6ZD60J)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\ubc-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000014gn   Danio rerio Zebrafish  Drer\ube2b   Danio rerio Zebrafish  Drer\CH211-235E18.1   Danio rerio Zebrafish  Drer\ube2a   Xenopus tropicalis Western clawed frog  Xtro\ube2a   Xenopus tropicalis Western clawed frog  Xtro\ube2b   Gallus gallus Domestic chicken  Ggal\UBE2B   Gallus gallus Domestic chicken  Ggal\UBE2A   Mus musculus House mouse  Mmus\Ube2b   Mus musculus House mouse  Mmus\Ube2a   Rattus norvegicus Norway rat  Rnor\Ube2a   Rattus norvegicus Norway rat  Rnor\Ube2b   Homo sapiens Human  Hsap\UBE2A   Homo sapiens Human  Hsap\UBE2B
Human Orthologs (2)
Gene OMIM HGNC Hsap\UBE2A     Hsap\UBE2B
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD19645 Drosophila sechellia Dsec\GM10669 Drosophila erecta Dere\GG11277 Drosophila yakuba Dyak\GE25319 Drosophila ananassae Dana\GF16080 Drosophila pseudoobscura pseudoobscura Dpse\GA15184 Drosophila persimilis Dper\GL22213 Drosophila willistoni Dwil\GK14053 Drosophila virilis Dvir\GJ10109 Drosophila mojavensis Dmoj\GI22506 Drosophila grimshawi Dgri\GH15302
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	42631 y1 v1; P{TRiP.HMS02466}attP40 22751 y1 w67c23; Mi{ET1}UbcD6MB00268 35476 y1 sc* v1; P{TRiP.GL00405}attP2 35975 y1 w*; Mi{MIC}UbcD6MI02360/TM3, Sb1 Ser1 15757 y1 w67c23; P{EPgy2}UbcD6EY04634/TM3, Sb1 Ser1
Harvard	- P{XP}UbcD6d01923 - PBac{RB}UbcD6e01465
Kyoto	123489 w1118; P{RS3}UbcD6CB-5152-3
VDRC	v23229 w1118; P{GD13294}v23229 v23230 w1118; P{GD13294}v23230 v46927 w1118; P{GD17232}v46927/TM3
Genomic Clones ( 2 )
	BACR11M01 BACR20D10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 93 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH26355 RE56673
Other clones	MIP21565
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD22830 LP21365 RE03158 RE20281 RE28159 RE32824 RE33715 RE38305 RE42554 RE43723 RE48019 RE49353 RE50294 RE51253 RE51503 RE65736 SD14285 SD23048 SD23738 SD23883
Other clones	34689 34836 35713 37372 44497 47383 53506 56722 76174 102095 106300 107784 109256 121186 148980 156109 156518 157307 172687 178664 214469.64 274071 527000 CK01.10D.E10 CK01.11C.G11 CK01.14D.D8 CK01.15A.B6 CK01.33A.F3 CK01.40C.B12 CK01.50D.B2 CK01.80D.G2 CK01.142D.C8 CK01.168C.E5 EC02936 EC03136 EC28568 EK012849 EK015239 EK041737 EK062557 EK103319 EK116044 EK121906 EK139503 EK144628 EK144820 EK146718 EK149212 EK160117 EK170856 EK199502 EK207903 EK225307 EK231716 EK241421 EK255130 EK257003 EK259033 EK259641 EK264056 EK266106 EK301817 EN07114 EP00423 ESG0113a.B21_G10 FGC017E09 FGH107B11 FGM324B11 GM02425 RE21747
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004436 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40610
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: UbcD6 CG2013 (Guan, 1999.11)
Source for database merge of	Source for merge of: UbcD6 BcDNA:RE56673 (FlyBase, 1996-)
Additional comments	Source for merge of UbcD6 BcDNA:RE56673 was a shared cDNA (date:030728). (FlyBase, 1996-) UbcD6 increases the UV resistance of S.cerevisiae Scer\rad6 mutant cells, although not to wild-type levels. The γ ray sensitivity of S.cerevisiae Scer\rad6 mutant cells is also complemented by UbcD6, to almost wild-type levels. The sporulation defect of S.cerevisiae Scer\rad6 mutant cells is not rescued by UbcD6. (Koken et al., 1991)
Other Comments
	UbcD6 negatively regulates p53 turnover. (Chen et al., 2011) UbcD6 is involved in centrosome separation. (Dobbelaere et al., 2008) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes defects in the formation of monastral bipolar spindles when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA. (Goshima et al., 2007) RNAi screen using dsRNA made from templates generated with primers directed against this gene in S2 cells does not affect the number of prophase centrosomes, but monastral bipolar spindles are formed during mitosis, suggesting that the centrosomes are fused. (Goshima et al., 2007) Area matching Drosophila RAD6 gene, Acc. No. M63792. (Davies, 2001.3.15) Isolated from a genomic library using a Scer\rad6 DNA fragment and a S.pombe rhp6 DNA fragment as probes. (Koken et al., 1991) UbcD6 has been cloned and sequenced. (Koken et al., 1991)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079506 NM_001170037 NM_001259987 NM_001259988 RefSeq (Proteins) • NP_524230 NP_001163508 NP_001246916 NP_001246917 DDBJ / EMBL / GenBank • AA817430 AAA28308 AAA28309 AAF52079 AAO39484 ACZ94807 AFH06235 AFH06236 AI455302 AX093930 BI372016 BT003481 CZ472517 CZ472518 CZ479281 M63791 M63792 M64435 Entrez Gene - A searchable database of RefSeq genes. • 40610 UniProtKB/Swiss-Prot • P25153 UniProtKB/TrEMBL • E1JJ49
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ubiquitin-conjugating enzyme, E2 (IPR000608) Ubiquitin-conjugating enzyme/RWD-like (IPR016135) Ubiquitin-conjugating enzyme, active site (IPR023313) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH26355
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0004436 DRSC - Results from RNAi screens. • FBgn0004436 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004436 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2013-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004436 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40610 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40610 modMine - Data generated by the modENCODE project. • FBgn0004436 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P25153
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	BcDNA:RE56673   CG2013 (Goshima et al., 2007, Ardehali et al., 2009, Dobbelaere et al., 2008, Ni et al., 2011.7.19, Ni et al., 2010.12.1) Dhr6 (Speese et al., 2003, Prakash et al., 1993, Oh et al., 1994, Koken et al., 1991, ) RAD6 (Higa et al., 2003) Rad6 (Speese et al., 2003, Chen et al., 2011) UbcD6 (Goshima et al., 2007, Rathke et al., 2007, Stuart et al., 2007, Nybakken et al., 2005, Goshima et al., 2007, Ardehali et al., 2009, Michelle et al., 2009, Carbone et al., 2009, Dobbelaere et al., 2008, Rathke et al., 2007, Kaplow et al., 2007)
Name Synonym	Ubiquitin conjugating enzyme   Ubiquitin Conjugating Enzyme (Kaplow et al., 2007)
Secondary FlyBase IDs
	FBgn0064873
References ( 42 )
Generate a list of	All references relating to this gene ( 42 )
List References by type	Research paper  ( 17 ) Supplementary material  ( 3 ) Review  ( 1 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 1 ) FlyBase analysis  ( 3 ) Curated genome annotation  ( 3 ) Patent  ( 1 ) DNA/RNA sequence record  ( 1 ) Protein sequence record  ( 1 )
Recent research papers ( 1 )
	Chen et al., 2011, J. Biol. Chem. 286(11): 9020--9030 E2 Ligase dRad6 Regulates DMP53 Turnover in Drosophila. [FBrf0213391] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...