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General Information
Symbol
Dmel\Ten-m
Species
D. melanogaster
Name
Tenascin major
Annotation Symbol
CG5723
Feature Type
FlyBase ID
FBgn0004449
Gene Model Status
Stock Availability
Gene Snapshot
Tenascin major (Ten-m) encodes a type II dimeric transmembrane protein whose extracellular domain mediates interactions with itself and with its paralogous protein encoded by Ten-a. It also interacts intracellularly with cytoskeleton regulatory proteins. Ten-m product regulates synaptic partner matching and axon guidance in the embryonic nervous system, as well as synaptic organization in olfactory and neuromuscular systems. [Date last reviewed: 2018-09-06]
Also Known As
odz, Tenm, odd Oz, Teneurin, odd-Oz
Key Links
Genomic Location
Cytogenetic map
Sequence location
3L:22,293,044..22,407,863 [-]
Recombination map
3-47
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
Belongs to the tenascin family. Teneurin subfamily. (O61307)
Summaries
Protein Function (UniProtKB)
Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Acts as a homophilic and heterophilic synaptic cell adhesion molecule that drives synapse assembly. Promotes bi-directional trans-synaptic signaling with Ten-a to organize neuromuscular synapses. Functions in olfactory synaptic partner matching by promoting homophilic cell adhesion between pre-synaptic olfactory receptor neurons (ORN) axons and post-synaptic projection neurons (PN) dendrites partner in the developing antennal lobe to form stable connections. Also required for peripheral axon growth cone guidance and target recognition of motor neurons.
(UniProt, O61307)
Summary (Interactive Fly)
transmembrane protein that acts together with the filamin Cheerio to influence growth cone progression - acts in projection neurons autonomously to regulate acetylcholine receptor cluster number and transsynaptically to regulate olfactory receptor neuron active zone number
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
3

Please see the GBrowse view of Dmel\Ten-m or the JBrowse view of Dmel\Ten-m for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.44
Stop-codon suppression (UGA) postulated; FBrf0216884.
gene_with_stop_codon_read_through ; SO:0000697
Gene model reviewed during 5.45
Gene model reviewed during 5.56
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0078509
11411
2731
FBtr0306107
12169
3297
FBtr0330159
12169
3349
Additional Transcript Data and Comments
Reported size (kB)
11.5, 10.5 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0078161
304.1
2731
6.76
FBpp0297244
366.1
3297
6.00
FBpp0303192
372.0
3349
5.77
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
2515 (aa); 900, 270 (kD observed); 281 (kD predicted)
>2406 (aa); 70, 55 (kD observed); 300 (kD predicted)
Comments
By Western and immunoprecipitation analyses, the Ten-m protein appears to be a large 900-1000kD secreted proteoglycan. After digestion with chondroitinase ABC, a ~270 kD core is released, whose size agrees well with the predicted molecular weight of 281 kD. Ten-m, a putative secondary pair rule gene product, is an extracellular protein.
The predicted 300 kD Ten-m protein might be post-translationally modified to give the 55 and 70 kD forms observed on Western blots. The EGF repeats of the Ten-m protein show 39% amino acid identity with the EGF repeats of mouse tenascin.
The predicted 300 kD Ten-m protein might be post-translationally modified to give the 55 and 70 kD forms observed on Western blots. The EGF repeats of the Ten-m protein show 39% amino acid identity with the EGF repeats of mouse tenascin.
External Data
Subunit Structure (UniProtKB)
Homodimer. Heterodimer with Ten-a. Interacts with Ten-a; the interaction occurs at the neuromuscular junction. Interacts with alpha-Spec and cher.
(UniProt, O61307)
Post Translational Modification
Phosphorylated. Phosphorylation occurs at tyrosine residues. Proteolytically cleaved.
(UniProt, O61307)
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ten-m using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (31 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from physical interaction with UniProtKB:Q9VYN8
(assigned by UniProt )
inferred from physical interaction with UniProtKB:Q9NGK5
(assigned by UniProt )
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
(assigned by UniProt )
Terms Based on Predictions or Assertions (0 terms)
Biological Process (20 terms)
Terms Based on Experimental Evidence (20 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from direct assay
(assigned by UniProt )
inferred from mutant phenotype
(assigned by UniProt )
inferred from direct assay
(assigned by UniProt )
inferred from mutant phenotype
inferred from direct assay
(assigned by UniProt )
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
(assigned by UniProt )
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000131583
(assigned by GO_Central )
Cellular Component (6 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
(assigned by UniProt )
inferred from high throughput direct assay
inferred from direct assay
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from sequence or structural similarity
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
organism | segmentally repeated

Comment: reference specifies 2.5-3.5 hr AEL

organism | segmentally repeated

Comment: reference states 4.5-7.5 hr AEL

mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
At the cellular blastoderm stage (2.5 hours), Ten-m protein is visible at the periphery of cells, suggesting a plasma-membrane associated or extracellular localization.
At embryonic stage 8, Ten-m (as well as cher), is expressed in all furrows and in the posterior midgut. It is expressed in a repetitive pattern at stage 11. By stage 13, it is epressed in the ventral nerve cord. At stage 15, Ten-m is expressed in the axons of the CNS. It is expressed in bands of epidermal cells at segmental boundaries, where it colocalizes with cher.
Ten-m is expressed posterior to the morphogenetic furrow in the third instar eye disc, and as point-like expression in more mature developing ommatidia. At higher resolutions, Ten-m can be seen in four staggered columns of preclusteres after the furrow, at the periphery of cells.
Ten-m protein is expressed in a complex pattern of the eye-antennal disc in the third instar larva. Protein is distributed in in a row of cells in the morphogenetic furrow, and in two rows posterior to the furrow; staining in these cells is uniform, and consistant with a cell surface distribution. No staining is observed for another 10 cell diameters, after which Ten-m expression is observed in a single cell, likely the R7 photoreceptor cell, of each maturing ommatidium. Expression is also observed in the optic stalk, and in two clusters of adepithelial cells, one in the eye disc and one in the antennal disc. Expression in the antennal disc is observed in the presumptive maxillary palpus, in the presumptive antennal segments, in the presumptive head capsule, and in the presumptive rostral membrane.
Ten-m protein is expressed in a complex pattern in the wing disc. In the wing pouch, it is expressed in two hook-shaped contiguous lines of expression in apposing patterns on either side of the dorsal/ventral boundary; a portion of each parallels about a quarter of the dorsal/ventral boundary at a distance of 3-4 cell lengths, then turns to follow the anterior/posterior boundary at about the location of the presumptive third longitudinal wing vein. Expression is also observed in the presumptive first, third, and fourth axillary sclerites, in the presumptive prealar apophysis, the presumptive pleural wing process, the presumptive yellow club, the presumptive pleural wing sclerite, and in the dorsal tissue giving rise to the proximal dorsal radius and the sensilla campaniformia that cover it. Expression is also observed in the presumptive proximal costal vein, in the presumptive prescutum and scutum, in the presumptive anterior and posterior notal wing processes, the presumptive tegula, the presumptive alula, the presumtive axillary cord, and in the regions of presumptive pleura adjacent to the wing.
Ten-m protein expression is strong in the regions of the haltere disc that give rise to the sensilla of the dorsal and ventral pedicel, and of dorsal and ventral scabellum. Ten-m protein is distributed in concentric rings in the leg discs, corresponding to the segments of the adult leg.
The Ten-m protein is present uniformly in the anterior-posterior axis, and in an anterior domain in stage 5 embryos, but by stage 6, a repetitive pattern comprising seven full stripes and two partial stripes are visible. By stage 8, Ten-m protein is present in the anterior and posterior transverse furrows, and in the posterior midgut primordia, with decreasing staining in the ectoderm. By stage 9, Ten-m protein is only visible in the mesoderm. At stage 10, the neuroblasts of the procephalic lobe stain for Ten-m protein, and from stage 12 to 15 Ten-m protein is visible in the axons of the ventral nerve cord. At stage 11, staining in the tracheal system becomes visible. At stages 12-13, staining is also seen in cardiac cells. At stage 16, muscle attachment sites show staining.
The 7 stripe segmentally repeated pattern of Ten-m protein expression in 2.5 to 3.5 hour embryos is followed by a 14-stripe segmentally repeated pattern of expression at 4.5 to 7.5 hours. The most intense segmentally repeated staining is seen in the mesoderm. At 9.5 hours, Ten-m protein is found in cardiac mesoderm cells, which will become cardioblasts. Also at 9.5 hours, and continuing through embryogenesis, is central nervous system staining of longitudinal and commissural axon tract bundles.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
(assigned by UniProt )
inferred from high throughput direct assay
inferred from direct assay
Expression Deduced from Reporters
Reporter: P{GawB}Ten-mNP6658
Stage
Tissue/Position (including subcellular localization)
Reference
Stage
Tissue/Position (including subcellular localization)
Reference
Stage
Tissue/Position (including subcellular localization)
Reference
adult brain | restricted

Comment: not in mushroom body and ellipsoid body

Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Ten-m in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 55 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Ten-m
Transgenic constructs containing regulatory region of Ten-m
Deletions and Duplications ( 17 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (8)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
11 of 15
Yes
Yes
11 of 15
Yes
Yes
10 of 15
No
Yes
9 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (8)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
11 of 15
Yes
Yes
11 of 15
Yes
Yes
10 of 15
No
Yes
9 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (4)
9 of 13
Yes
Yes
7 of 13
No
No
4 of 13
No
Yes
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (6)
5 of 12
Yes
Yes
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
Danio rerio (Zebrafish) (10)
10 of 15
Yes
Yes
6 of 15
No
Yes
4 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (6)
13 of 15
Yes
Yes
2 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919002H )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150025 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0018 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X002I )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G003Y )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ciona intestinalis
Vase tunicate
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (3)
6 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    Homodimer. Heterodimer with Ten-a. Interacts with Ten-a; the interaction occurs at the neuromuscular junction. Interacts with alpha-Spec and cher.
    (UniProt, O61307 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map
    3-47
    Cytogenetic map
    Sequence location
    3L:22,293,044..22,407,863 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    79D4-79E3
    Limits computationally determined from genome sequence between P{lacW}l(3)j1B10j1B10 and P{lacW}l(3)j2C4j2C4
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    79E1-79E2
    (determined by in situ hybridisation)
    79E-79E
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Location
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (39)
    Genomic Clones (78)
    cDNA Clones (83)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       
      monoclonal, polyclonal
      Commercially Available Antibodies
       
      Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
      Other Information
      Relationship to Other Genes
      Source for database identify of
      Source for identity of: Ten-m CG5723
      Source for database merge of
      Source for merge of: Ten-m l(3)05301
      Source for merge of: Ten-m BcDNA:AT25108
      Additional comments
      Source for merge of Ten-m BcDNA:AT25108 was a shared cDNA ( date:030728 ).
      Complementation tests show that the Ten-m locus is distinct from bch and l(3)7E103.
      Other Comments
      Ten-m instructs synaptic partner matching of projection neuron dendrites to the appropriate olfactory receptor neuron axon through homophilic attraction.
      Ten-m loss of function mutations do not show a pair-rule segmentation phenotype. The pair-rule phenotype previously reported for a number of Ten-m mutations has been shown to be due to a mutation present on the balancer in the original stock.
      dsRNA made from templates generated with primers directed against this gene used in a cell-based RNAi assay to identify components or modifiers of the JAK/STAT pathway.
      dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
      RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in S2R+ cells: cells become round and detached. Kc167 cells are unaffected.
      It is possible that the mutation referred to as "l(3)00844" in FBrf0082995 is actually l(3)0086400864. Ten-m is at 79E whereas the insertion in FBrf0082995 is clearly shown as mapping to between 75C5-7 and 75F1, as does l(3)0086400864.
      Ten-m encodes a type I transmembrane protein with the vast C-terminal portion in the intracellular space. The polypeptide undergoes multiple cleavages at discrete intracellular and extracellular sites and its extreme C-terminus undergoes either processing at a very large number of sites or programmed degradation. The polypeptide is presented at the cell surface as two subunits of previously cleaved protein joined by cysteine disulphide bridges and it has additional post-translational modifications.
      Ten-m has been characterised as a potential ligand of PS2 integrins by functional interaction in cell culture.
      Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland.
      Identification: Enhancer trap screen designed to discover genes involved in the cellular aspects of defense mechanisms, as well as in melanotic tumor formation processes linked to blood cell disregulation.
      Genetics and molecular structure of Ten-m.
      FlyBase curator comment: It is possible that the mutation referred to as "l(3)00844" is actually l(3)0086400864. Ten-m is at 79E whereas the insertion in FBrf0082995 is clearly shown as mapping to between 75C5-7 and 75F1, as does l(3)0086400864. See Roote, 2003.11.28, personal communication to FlyBase for explanation of this.
      FlyBase curator comment: FBrf0214744 characterises new loss of function mutations in Ten-m and finds no evidence of a pair-rule segmentation phenotype, in contrast to previous reports. The authors show that the pair-rule phenotype previously reported for a number of Ten-m mutations (Ten-m05309, Df(3L)Ten-m-AL1 and Df(3L)Ten-m-AL29) was in fact due to a mutation present on the balancer in the original stock.
      Origin and Etymology
      Discoverer
      Etymology
      The name 'odd Oz' was suggested for this gene because of the 'odd' pair rule phenotype, and the observation that the mutant phenotype affects structures corresponding to the three gifts bestowed by the Wizard of Oz, namely heart, brain and nervous system (courage). FlyBase curator comment: FBrf0214744 has subsequently shown that loss of function Ten-m mutations do not have a pair-rule phenotype, and that the the pair-rule phenotype previously reported for a number of Ten-m mutations was in fact due to a mutation present on the balancer in the original stock.
      Identification
      External Crossreferences and Linkouts ( 67 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyMine - An integrated database for Drosophila genomics
      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Synonyms and Secondary IDs (34)
      Reported As
      Symbol Synonym
      BcDNA:AT25108
      Ten79E
      l(3)05301
      l(3)rJ307
      l(3)rL201
      l(3)rP126
      Secondary FlyBase IDs
      • FBgn0010864
      • FBgn0011500
      • FBgn0011513
      • FBgn0011526
      • FBgn0011680
      • FBgn0024864
      • FBgn0037160
      • FBgn0047332
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (151)