FB2020_01, released Feb 12, 2020

Gene: Dmel\mew

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General Information
Symbol
Dmel\mew
Species
D. melanogaster
Name
multiple edematous wings
Annotation Symbol
CG1771
Feature Type
protein_coding_gene
FlyBase ID
FBgn0004456
Gene Model Status
Current
Stock Availability
26 publicly available
Gene Snapshot
multiple edematous wings (mew) encodes one of 5 fly integrin alpha subunits, and when in a heterodimer with an integrin beta subunit makes a receptor for the extracellular matrix protein laminin. It is required in numerous tissues for cell migration, adhesion between cell layers, and cell differentiation. [Date last reviewed: 2019-03-14]
Other Summaries
Also Known As

αPS1, αPS1, PS1, αPS1 integrin, PS1α

Key Links
Genomic Location
Cytogenetic map
11E3-11E8
Sequence location
X:13,214,409..13,258,490 [-]
Recombination map

1-42

RefSeq locus
NC_004354 REGION:13214409..13258490
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the integrin alpha chain family. (Q24247)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
cell adhesion molecule binding; extracellular matrix binding; protein heterodimerization activity
Predictions / Assertions
-
Summaries
Gene Group (FlyBase)
INTEGRINS -
Integrins are heterodimeric transmembrane receptors composed of an α and β subunit that mediate cell-cell and cell-extracellular matrix adhesion. As well as maintaining tissue integrity, they are involved in morphogenesis and development. (Adapted from FBrf0167428).
Protein Function (UniProtKB)
Integrin alpha-PS1/beta-PS is a receptor for laminin.
(UniProt, Q24247)
Gene Model and Products
Number of Transcripts
6
Number of Unique Polypeptides
6

Please see the GBrowse view of Dmel\mew or the JBrowse view of Dmel\mew for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Stop-codon suppression (UAA) postulated; FBrf0216884.

Gene model reviewed during 5.43

Shares 5' UTR with upstream gene.

gene_with_stop_codon_read_through ; SO:0000697

Gene model reviewed during 5.44

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene
gene_with_stop_codon_read_through
(Jungreis et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
mew-RA
FBtr0073731
NM_167354
3863
1049
mew-RB
FBtr0073732
NM_078590
5001
1146
mew-RC
FBtr0310647
NM_001272575
4281
1155
mew-RD
FBtr0310648
NM_001272576
4350
1058
mew-RE
FBtr0330398
NM_001272574
3863
1146
mew-RF
FBtr0340190
NM_001298267
4254
1243
Additional Transcript Data and Comments
Reported size (kB)

5.4 (northern blot)

(Wehrli et al., 1993)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
mew-PA
FBpp0073562
117.1
1049
5.77
NP_727679
AAN09652
mew-PB
FBpp0073563
128.0
1146
6.27
NP_511145
AAF48242
mew-PC
FBpp0302767
129.0
1155
6.31
NP_001259504
AGB95346
mew-PD
FBpp0302768
118.1
1058
5.84
NP_001259505
AGB95347
mew-PE
FBpp0303424
128.3
1146
6.46
NP_001259503
AGB95345
mew-PF
FBpp0309167
139.2
1243
6.77
NP_001285196
AHN59666
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)

1146 (aa); 128 (kD predicted)

(Wehrli et al., 1993)
Comments
External Data
Subunit Structure (UniProtKB)

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-PS1 associates with beta-PS.

(UniProt, Q24247)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mew using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (29 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
cell adhesion molecule binding
inferred from mutant phenotype
(Roote and Zusman, 1995)
extracellular matrix binding
inferred from direct assay
(Gotwals et al., 1994)
protein heterodimerization activity
inferred from physical interaction with FLYBASE:mys; FB:FBgn0004657
(Gotwals et al., 1994)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (20 terms)
Terms Based on Experimental Evidence (12 terms)
CV Term
Evidence
References
actin filament organization
inferred from mutant phenotype
(Delon and Brown, 2009)
axon guidance
inferred from mutant phenotype
(Stevens and Jacobs, 2002)
axonal defasciculation
inferred from mutant phenotype
(Huang et al., 2007)
cell adhesion
inferred from mutant phenotype
(Roote and Zusman, 1995)
cell adhesion mediated by integrin
inferred from mutant phenotype
(Brabant et al., 1996)
inferred from direct assay
(Gotwals et al., 1994)
imaginal disc-derived wing morphogenesis
inferred from expression pattern
(Brabant et al., 1996)
inferred from mutant phenotype
(Brabant et al., 1996)
maintenance of epithelial integrity, open tracheal system
inferred from genetic interaction with FLYBASE:if; FB:FBgn0001250
(Levi et al., 2006)
muscle attachment
inferred from genetic interaction with FLYBASE:Grip; FB:FBgn0029830
(Estrada et al., 2007)
inferred from genetic interaction with FLYBASE:kon; FB:FBgn0032683
(Estrada et al., 2007)
salivary gland boundary specification
inferred from mutant phenotype
(Kolesnikov and Beckendorf, 2005)
salivary gland morphogenesis
inferred from genetic interaction with FLYBASE:βTub85D; FB:FBgn0003889
(Jattani et al., 2009)
sensory perception of smell
inferred from genetic interaction with FLYBASE:sws; FB:FBgn0003656
(Ayyub and Paranjape, 2002)
substrate adhesion-dependent cell spreading
inferred from direct assay
(Gotwals et al., 1994)
Terms Based on Predictions or Assertions (9 terms)
CV Term
Evidence
References
apposition of dorsal and ventral imaginal disc-derived wing surfaces
non-traceable author statement
(Brower, 2003)
cell differentiation
traceable author statement
(Brown, 2000)
cell migration
traceable author statement
(Brown, 2000)
cell-cell adhesion
traceable author statement
(Brown, 2000)
ectodermal digestive tract morphogenesis
traceable author statement
(Brown, 2000)
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
traceable author statement
(Hynes and Zhao, 2000)
imaginal disc-derived wing morphogenesis
traceable author statement
(Brown, 2000)
midgut development
traceable author statement
(Brown, 2000)
salivary gland development
traceable author statement
(Abrams et al., 2003)
Cellular Component (6 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
apical plasma membrane
inferred from direct assay
(assigned by UniProt )
(Dinkins et al., 2008)
basal plasma membrane
inferred from direct assay
(Brabant et al., 1996)
focal adhesion
inferred from direct assay
(Delon and Brown, 2009)
integral component of plasma membrane
inferred from direct assay
(Gotwals et al., 1994)
integrin complex
inferred from direct assay
(Gotwals et al., 1994)
lateral plasma membrane
inferred from direct assay
(assigned by UniProt )
(Dinkins et al., 2008)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
integrin complex
non-traceable author statement
(Brower, 2003)
inferred from sequence or structural similarity with HGNC:6139
(Brown, 2000)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11 -- 12
presumptive embryonic salivary gland
(Bradley et al., 2003)
anterior midgut primordium
(Fisher et al., 2012)
clypeo-labral primordium
(Fisher et al., 2012)
dorsal epidermis primordium
(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
garland cell primordium
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
lateral cord
(Fisher et al., 2012)
longitudinal visceral muscle primordium
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
proventriculus primordium
(Fisher et al., 2012)
salivary gland body primordium
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
embryonic stage 12
tracheal pit
(Bradley et al., 2003)
embryonic stage 4 -- 6
dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
anterior endoderm anlage
(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
hindgut anlage
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
anterior endoderm
(Fisher et al., 2012)
clypeo-labral primordium
(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
inclusive hindgut primordium
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic esophagus
(Fisher et al., 2012)
embryonic foregut
(Fisher et al., 2012)
embryonic foregut sensory structure
(Fisher et al., 2012)
embryonic head epidermis
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic leading edge cell
(Fisher et al., 2012)
embryonic proventriculus
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
embryonic/larval garland cell
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
embryonic/larval muscle system
(Fisher et al., 2012)
embryonic/larval salivary gland
(Fisher et al., 2012)
embryonic/larval visceral muscle
(Fisher et al., 2012)
longitudinal visceral muscle fiber
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 13
longitudinal visceral muscle primordium
(Urbano et al., 2011)
radioisotope in situ
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
adepithelial cell of wing disc
(Wehrli et al., 1993)
wing disc
(Wehrli et al., 1993)
peripodial epithelium
(Wehrli et al., 1993)
embryonic stage
embryonic/larval posterior midgut
(Wehrli et al., 1993)
presumptive embryonic/larval central nervous system
(Wehrli et al., 1993)
ectoderm
(Wehrli et al., 1993)
embryonic/larval anterior midgut
(Wehrli et al., 1993)
Additional Descriptive Data

Transcript was detected in stage 11 salivary gland primordia coincident with salivary gland internalization. Expression continued in all cells through stage 12 with high expression in invaginating cells. Transcritp was no longer detectable at stage 14. mew is also expressed in the invaginating tracheal pits.

(Bradley et al., 2003)

mew transcripts are first detected at the cellular blastoderm stage in the cells of the presumptive ectoderm. During gastrulation, the transcript is apparent over the entire ectoderm with increased levels in the dorsal region. In stage 8, high transcript levels are observed in the ectoderm and in the anterior and posterior midgut primordia. By stage 11, a strong segmentally repeated pattern has been established in the ectoderm and the CNS. The regions of high concentration are correlated with segment boundaries. Strong mew expression is also detected in the dorsal compartment of the wing disc as well as in adepithelial cells and on the peripodial membrane.

(Wehrli et al., 1993)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
oogenesis
follicle cell | lateral
(Dinkins et al., 2008)
follicle cell | apical
(Dinkins et al., 2008)
follicle cell | basal
(Dinkins et al., 2008)
border follicle cell
(Dinkins et al., 2008)
oocyte associated follicle cell
(Dinkins et al., 2008)
oogenesis stage S9 -- S11
dorsal appendage forming follicle cell
(Dinkins et al., 2008)
embryonic stage 15 -- 17
embryonic cardioblast | apical
(Vanderploeg et al., 2012)
adult stage
intestinal stem cell | basal
(Lin et al., 2013)
enteroblast | basal
(Lin et al., 2013)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data

The α1 integrin, mew, strongly accumulates on the basal membrane of esg-positive cells contacting ECM, but is barely detected in any other regions along the interface between the muscle cells and the differentiated epithelial cells.

(Lin et al., 2013)

In stage 15 embryos, before the leading processes of the cardioblasts make contact across the midline, mew is localised primarily on the leading edge of the migrating cardioblasts, and less so on the trailing edge. This preponderantly apical distribution was not significantly altered once the heart lumen was formed at stage 17.

(Vanderploeg et al., 2012)

mew staining is observed along lateral, apical, and basal follicle cell membranes through stage 10A. Apical staining peaks in stage 9 and 10A columnal follicle cells overlying the oocyte while downregulating in the most posterior follicle cells. Expression is also seen in border cells at intercellular junctions. After stage 10A, the remaining follicle cell populations begin down-regulating apically localized mys while maintaining lateral and basal localization during dorsal appendage morphogenesis. Staining is observed from stage 9 in dorsal appendage forming follicle cells.

(Dinkins et al., 2008)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
apical plasma membrane
inferred from direct assay
(assigned by UniProt )
(Dinkins et al., 2008)
basal plasma membrane
inferred from direct assay
(Brabant et al., 1996)
focal adhesion
inferred from direct assay
(Delon and Brown, 2009)
integral component of plasma membrane
inferred from direct assay
(Gotwals et al., 1994)
integrin complex
inferred from direct assay
(Gotwals et al., 1994)
lateral plasma membrane
inferred from direct assay
(assigned by UniProt )
(Dinkins et al., 2008)
Expression Deduced from Reporters
Reporter: PBac{681.P.FSVS-1}mewCPTI001678
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain cell body rind
(Knowles-Barley, 2011.8.24)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\mew in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 34 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of mew
Transgenic constructs containing regulatory region of mew
Deletions and Duplications ( 4 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | recessive
lethal - all die before end of larval stage
lethal - all die before end of larval stage | recessive
partially lethal - majority die | female
partially lethal - majority die | male
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
Other Phenotypes
Allele
decreased cell number | adult stage | somatic clone
neuroanatomy defective
neuroanatomy defective | somatic clone | third instar larval stage, with Scer\GAL4109(2)80
short lived, with Scer\GAL4Ugt36A1.PK
size defective | adult stage | somatic clone
some die during larval stage
some die during larval stage | recessive
visible | recessive | heat sensitive
Phenotype manifest in
Allele
adult pericardial cell, with Scer\GAL4Ugt36A1.PK
adult posterior midgut epithelium | somatic clone
anterior midgut primordium
dorsal branch primordium, with Scer\GAL4btl.PS
embryonic/larval midgut
embryonic/larval midgut | embryonic stage
embryonic/larval salivary gland
embryonic/larval visceral branch
embryonic midgut constriction
fascicle
filamentous actin | somatic clone
follicle cell | somatic clone
intersegmental nerve
larval dorsal multidendritic neuron ddaC | somatic clone | third instar larval stage, with Scer\GAL4109(2)80
mitotic domain 1 | extended germ band stage
muscle attachment site | embryonic stage
oocyte | oogenesis stage S14
photoreceptor
presumptive embryonic/larval central nervous system
presumptive embryonic/larval digestive system
presumptive embryonic/larval peripheral nervous system
presumptive embryonic salivary gland
retina
retina | somatic clone
salivary gland common duct primordium
segmental nerve
wing
wing | heat sensitive
wing | somatic clone
wing blade dorsal compartment | somatic clone
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ITGA6
12 of 15
Yes
Yes
Hsap\ITGA7
11 of 15
No
Yes
Hsap\ITGA3
9 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Itga6
11 of 15
Yes
Yes
Mmus\Itga7
11 of 15
Yes
Yes
Mmus\Itga3
9 of 15
No
Yes
Rattus norvegicus (Norway rat) (3)
Rnor\Itga7
9 of 13
Yes
Yes
Rnor\Itga3
7 of 13
No
Yes
Rnor\Itga6
5 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (4)
Xtro\itga6
7 of 12
Yes
Yes
Xtro\itga2b.1
1 of 12
No
No
Xtro\itga2b.2
1 of 12
No
No
Xtro\itga7
1 of 12
No
Yes
Danio rerio (Zebrafish) (6)
Drer\itga6a
12 of 15
Yes
Yes
Drer\itga3b
9 of 15
No
Yes
Drer\itga6b
8 of 15
No
Yes
Drer\itga6l
8 of 15
No
Yes
Drer\itga3a
7 of 15
No
Yes
Drer\itga7
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\ina-1
10 of 15
Yes
Yes
Cele\pat-2
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919014N )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\mew
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00006340
Drosophila simulans
Dsim\GD15896
Drosophila sechellia
Dsec\GM11503
Drosophila erecta
Dere\GG19513
Drosophila yakuba
Dyak\GE16168
Drosophila ananassae
Dana\GF20867
Drosophila pseudoobscura pseudoobscura
Dpse\GA14619
Drosophila persimilis
Dper\GL13410
Drosophila willistoni
Dwil\GK14819
Drosophila virilis
Dvir\GJ15708
Drosophila mojavensis
Dmoj\GI21563
Drosophila grimshawi
Dgri\GH24317
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500RR )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17010307
Glossina morsitans
Tsetse fly
Gmor\GMOY000248
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_04885
Mayetiola destructor
Hessian fly
Mdes\Mdes003322
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL001603
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL015560
Anopheles darlingi
American malaria mosquito
Adar\ADAC004175
Anopheles gambiae
Malaria mosquito
Agam\AGAP000307
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ003164
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00LS )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA005477
Danaus plexippus
Monarch butterfly
Dple\DPOGS207780-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL017583
Apis florea
Little honeybee
Aflo\2833311380
Apis mellifera
Western honey bee
Amel\GB49298
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP19173
Bombus terrestris
Buff-tailed bumblebee
Bter\15213087
Linepithema humile
Argentine ant
Lhum\LH16218
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00076b
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG003923
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12186
Tribolium castaneum
Red flour beetle
Tcas\TC034177
Pediculus humanus
Human body louse
Phum\PHUM257390
Rhodnius prolixus
Kissing bug
Rpro\RPRC015250
Rhodnius prolixus
Kissing bug
Rpro\RPRC015251
Cimex lectularius
Bed bug
Clec\CLEC003000
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001589
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_08009
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00KK )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR010929
Ixodes scapularis
Black-legged tick
Isca\ISCW005672
Stegodyphus mimosarum
African social velvet spider
Smim\KFM66138.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur08g07960
Tetranychus urticae
Two-spotted spider mite
Turt\tetur08g07970
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_314079
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_314098
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_60396
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G02JI )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_008204gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Api
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Adi
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Afi
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_019039gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Aci_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Agi
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_020175gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Aci_2
Ciona intestinalis
Vase tunicate
Cint\LOC100182403
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (4)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
if
3 of 10
ItgaPS4
2 of 10
ItgaPS5
2 of 10
scb
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 2 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ITGA6; integrin subunit alpha 6
    12 of 15
    147556
    ITGA7; integrin subunit alpha 7
    11 of 15
    600536
    ITGA3; integrin subunit alpha 3
    9 of 15
    605025
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Show neighbor-neighbor interactions:
      Select Layout:
      Legend:
      Protein
      RNA
      Selected Interactor(s)
      Interactions Browser
      View in Interactions Browser
      Please see the Physical Interaction reports below for full details
      protein-protein
      Physical Interaction
      Assay
      References
      mew - kon
      bead aggregation assay, fluorescence microscopy, inferred by author
      (Pérez-Moreno et al., 2017)
      mew - mys
      anti bait coimmunoprecipitation, autoradiography
      (Gotwals et al., 1994)
      mew - sog
      anti bait coimmunoprecipitation, western blot
      (Araujo et al., 2003)
      mew - tkv
      anti bait coimmunoprecipitation, anti tag western blot
      (Sawala et al., 2015)
      Summary of Genetic Interactions
      esyN Network Diagram
      esyN Network Key:
      Suppression
      Enhancement
      View in Interactions Browser
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      mew
      enhanceable
      blo
      (Walsh and Brown, 1998)
      mew
      enhanceable
      bs
      (Walsh and Brown, 1998)
      mew
      suppressible
      if::mew
      (Martin-Bermudo et al., 1997)
      mew
      suppressible
      if
      (Li et al., 1998, Martin-Bermudo et al., 1997, Roote and Zusman, 1996)
      mew
      enhanceable
      moa
      (Walsh and Brown, 1998)
      mew
      enhanceable
      pot
      (Walsh and Brown, 1998)
      mew
      enhanceable
      sli
      (Stevens and Jacobs, 2002)
      mew
      enhanceable
      Tsp
      (Chanana et al., 2007)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      14-3-3ε
      suppressible
      mew
      (Yang and Terman, 2012)
      ap
      suppressible
      fng|mew
      (O'Keefe and Thomas, 2001)
      fra
      enhanceable
      mew
      (Kolesnikov and Beckendorf, 2005)
      fry
      suppressible
      mew|mys
      (Han et al., 2012)
      H
      suppressible
      mew
      (Müller et al., 2005)
      if
      suppressible
      mew
      (Martin-Bermudo et al., 1997)
      if
      enhanceable
      mew
      (Prokop et al., 1998)
      mys
      suppressible
      mew
      (Han et al., 2012)
      parvin
      enhanceable
      mew
      (Chountala et al., 2012)
      raw
      suppressible
      mew|mys
      (Lee et al., 2015)
      Ret
      suppressible
      mew|mys
      (Soba et al., 2015)
      Sema2b
      suppressible
      mew|mys
      (Meltzer et al., 2016)
      Sin1
      suppressible
      mew|mys
      (Han et al., 2012)
      sli
      enhanceable
      mew
      (Stevens and Jacobs, 2002)
      sog
      suppressible
      mew
      (Araujo et al., 2003)
      Tsp
      enhanceable
      mew
      (Chanana et al., 2007)
      External Data
      Subunit Structure (UniProtKB)
      Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-PS1 associates with beta-PS.
      (UniProt, Q24247 )
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      External Data
      Linkouts
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      X
      Recombination map

      1-42

      Cytogenetic map
      11E3-11E8
      Sequence location
      X:13,214,409..13,258,490 [-]
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      11E3-11E8
      Limits computationally determined from genome sequence between P{EP}EP1461 and P{EP}CG1640EP1626
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      11E-11F
      (determined by in situ hybridisation) 11E1--4 (determined by in situ hybridisation) 11D1--2 (determined by in situ hybridisation)
      (Peter et al., 2002)
      11E-11F
      (determined by in situ hybridisation)
      (Schäfer et al., 1999.12.2)
      11E1-11E4
      (determined by in situ hybridisation)
      (Schäfer et al., 1999.8.12)
      11D7-11E4
      (determined by in situ hybridisation)
      (Wehrli and Wilcox, 1990)
      11D7-11E5
      (determined by in situ hybridisation)
      (Wehrli et al., 1993)
      Experimentally Determined Recombination Data
      Location

      1-42

      (FlyBase, 2016)

      1-42.0

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (26)
      Genomic Clones (21)
      cDNA Clones (25)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequences
      BDGP DGC clones
      Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         

        monoclonal

        (Gullberg et al., 1994)
        Commercially Available Antibodies
         
        Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
        Other Information
        Relationship to Other Genes
        Source for database identify of

        Source for identity of: mew CG1771

        (Gong, 1999.11)
        Source for database merge of

        Source for merge of: mew l(1)G0443 l(1)G0429

        (Peter et al., 2002)
        Additional comments
        Other Comments

        One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders.

        (Inlow and Restifo, 2004)

        Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day.

        (McDonald and Rosbash, 2001)

        mew and scb are required in a partially redundant way in the endoderm for normal migration of the endodermal midgut cells over the visceral mesoderm in the developing embryo.

        (Martin-Bermudo et al., 1999)

        The functional significance of the cytoplasmic domains of the if, mew and mys subunits of the Position Specific (PS) integrin family are studied by analysing the relationship between the cytoplasmic domain structure and function in the context of a developing organism. The cytoplasmic tail of mew is not required for function in the wing and in the retina.

        (Li et al., 1998)

        mew can mediate adhesion of the epidermal hemiadherens junctions to the basement membrane at muscle attachment sites in the developing embryo. This function appears to be mediated by LanA.

        (Prokop et al., 1998)

        The ability of two different integrin α subunits (encoded by mew and if) to substitute for each other during embryonic development has been studied. The two α subunits encoded by mew and if are not equivalent and have distinct functions which reside in the extracellular domains.

        (Martin-Bermudo et al., 1997)

        Clonal analysis demonstrates that the different integrins, mew and if, are required on opposite wing epithelia. An early integrin-dependent process, not obviously required for prepupal adhesion, is essential to permit subsequent wing morphogenesis.

        (Brabant et al., 1996)

        Loss of mew produces disorganisation along the basal surface of the retina. if function can replace mew function in the retina.

        (Roote and Zusman, 1996)

        Phenotypic analysis of mew, if and mys embryos suggests multiple roles for PS integrins in the adhesion of cells and in the formation, organization and migration of embryonic tissues. Although the proteins are often expressed in adjacent embryonic tissues, this distribution does not necessarily reflect equivalent requirements. The complete loss of both α subunits, encoded by mew and if, does not produce all the phenotypes observed in embryos lacking the mys encoded β subunit.

        (Roote and Zusman, 1995)

        mew gene product promotes cell spreading on two different extra cellular matrix (ECM) molecules, laminin and tiggin.

        (Gotwals et al., 1994)
        Origin and Etymology
        Discoverer
        Etymology

        The chosen gene symbol, "mew", will commemorate the name of the late Michael E. Wilcox, who made many important contributions to this field.

        (Brower et al., 1995)
        Identification
        External Crossreferences and Linkouts ( 65 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Synonyms and Secondary IDs (37)
        Reported As
        Symbol Synonym
        CG1771
        (Cammarato et al., 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Schiess et al., 2009, Bourbon et al., 2002, Whitfield, 2001.1.5)
        CT5254
        (Hynes and Zhao, 2000)
        ItgaPS1
        (Brown et al., 2013.2.5)
        Mew
        (Fu et al., 2017, Copf, 2015)
        PS1
        (Tomoyasu et al., 2009, Estrada et al., 2007, MacMullin and Jacobs, 2005, Solnica-Krezel and Eaton, 2003, Genova et al., 2000, Hobert and Westphal, 2000, Martin-Bermudo and Brown, 1999, Brabant et al., 1996, Fernandes et al., 1996, Cohen, 1993, Williams and Carroll, 1993, Peel and Milner, 1992)
        PS1α
        (Roy and VijayRaghavan, 1999, Madueno et al., 1995, Wessendorf et al., 1992, Hirano et al., 1991)
        PSα1
        (Delanoue et al., 2002)
        aPS1
        (Hoang and Chiba, 1998, Prokop et al., 1997)
        alpha-PS1
        (Wehrli, 1993.7.8)
        alphaPS1
        (Bouge et al., 2005)
        l(1)G0429
        (Schäfer et al., 1999.8.12)
        l(1)G0443
        (Schäfer et al., 1999.12.2)
        mew
        (Arbel et al., 2019, Deshpande et al., 2019, Jiang et al., 2019, Meltzer et al., 2019, Thuveson et al., 2019, Grobler et al., 2018, Park et al., 2018, Hermle et al., 2017, Kline et al., 2017, Pérez-Moreno et al., 2017, Transgenic RNAi Project members, 2017-, Clandinin and Owens, 2016-, Meltzer et al., 2016, Peters and Berg, 2016, Lee et al., 2015, Maartens and Brown, 2015, Myat et al., 2015, Panda et al., 2015, Sawala et al., 2015, Soba et al., 2015, Van Bortle et al., 2015, Ashwal-Fluss et al., 2014, Kim and Choe, 2014, Kim et al., 2014, You et al., 2014, Brown et al., 2013.2.5, Ismat et al., 2013, Lin et al., 2013, Nonaka et al., 2013, Pirraglia et al., 2013, Sen et al., 2013, Terriente-Felix et al., 2013, Thimgan et al., 2013, Weavers and Skaer, 2013, Yamamoto et al., 2013-, Cho et al., 2012, Gates, 2012, Han et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Kim et al., 2012, Jungreis et al., 2011, Lott et al., 2011, Negreiros et al., 2010, Popodi et al., 2010-, Tikhmyanova et al., 2010, Venken et al., 2010, Delon and Brown, 2009, Jattani et al., 2009, Krejcí et al., 2009, Schotman et al., 2009, Bai et al., 2008, Chen et al., 2008, Dinkins et al., 2008, O'Reilly et al., 2008, Schotman et al., 2008, Tsai et al., 2008, Zhang et al., 2008, Beltran et al., 2007, Chanana et al., 2007, Conder et al., 2007, Estrada et al., 2007, Huang et al., 2007, Junion et al., 2007, Levi et al., 2006, Curtin et al., 2005, Ayyub and Paranjape, 2002, FlyBase, 1992-)
        α-PS1
        (Aradhya et al., 2015)
        α1Int
        (Yang and Terman, 2012, Huang et al., 2007)
        αPS1
        (Chanana et al., 2007, Bradley et al., 2003, Fujimoto et al., 1999, Martin-Bermudo et al., 1999, Li et al., 1998, Prokop et al., 1998, Lin et al., 1997, Martin-Bermudo et al., 1997, Ashkenas et al., 1996, Blair et al., 1994, Fessler et al., 1994, Gullberg et al., 1994, Brown, 1993, Wehrli et al., 1993)
        αPS1
        (Park et al., 2018, Pérez-Moreno et al., 2017, Valdivia et al., 2017, Ashe, 2016, Peters and Berg, 2016, Sawala et al., 2015, Xie et al., 2014, Ismat et al., 2013, Lin et al., 2013, Pirraglia et al., 2013, Bulgakova et al., 2012, Chountala et al., 2012, Gates, 2012, Egoz-Matia et al., 2011, Urbano et al., 2011, Xie and Auld, 2011, Delon and Brown, 2009, Jattani et al., 2009, Krejcí et al., 2009, Chen et al., 2008, Dinkins et al., 2008, O'Reilly et al., 2008, Schotman et al., 2008, Fernández-Miñán et al., 2007, Subramanian et al., 2007, Takada et al., 2007, Tanentzapf et al., 2007, Lo, 2006, MacMullin and Jacobs, 2006, Curtin et al., 2005, Abrams et al., 2003, Brower, 2003, Schock and Perrimon, 2003, Baker et al., 2002, Bokel and Brown, 2002, Stevens and Jacobs, 2002, Araujo et al., 2001, Hughes, 2001, O'Keefe and Thomas, 2001, Brown, 2000, Brown et al., 2000, D'Avino and Thummel, 2000, Hynes and Zhao, 2000, Kim and Chiba, 2000, Martin-Bermudo, 2000, Beumer et al., 1999, Hoang and Chiba, 1998, Martin-Bermudo et al., 1997, Yarnitzky and Volk, 1995, Gotwals et al., 1994, Gotwals et al., 1994, Brown et al., 1993)
        Name Synonyms
        Integrin alphaPS1 subunit
        (Brown et al., 2013.2.5)
        Multiple edematous wings
        (Xie et al., 2014)
        PS I alpha
        (Kiss et al., 2016)
        PS1 integrin
        (Uv et al., 2003, Muller, 2000, Martinez Arias, 1993)
        PS1-Integrin
        (Peters and Berg, 2016)
        Position-specific-1 antigen
        (Fristrom and Fristrom, 1993)
        Position-specific-antigen-1α
        integrin PSII alpha subunit
        (Kiss et al., 2016)
        integrin αPS1
        (Schotman et al., 2009)
        integrin αPS1 subunit
        (Brown et al., 2013.2.5)
        multiple edematous wings
        (Sawala et al., 2015)
        multiple edematous wing
        (Pérez-Moreno et al., 2017, Ayyub and Paranjape, 2002)
        multiple edematous wings
        (Kim et al., 2014, Brown et al., 2013.2.5, Thimgan et al., 2013, Weavers and Skaer, 2013, Gates, 2012, Han et al., 2012, Cammarato et al., 2011, Egoz-Matia et al., 2011, Jattani et al., 2009, Schotman et al., 2009, Bai et al., 2008, Chen et al., 2008, Dinkins et al., 2008, O'Reilly et al., 2008, Chanana et al., 2007, Conder et al., 2007, Estrada et al., 2007, O'Keefe et al., 2007, Levi et al., 2006, Burnette et al., 2005, Burnette et al., 2005)
        α integrin
        (Fujimoto et al., 1997)
        α-PS1-integrin
        (Kohsaka et al., 2007, Goode et al., 1996)
        α1 Integrin subunit
        (Pasco et al., 2015)
        α1 integrin
        (Huang et al., 2007)
        αPS1 subunit of integrin
        (Chanana et al., 2007)
        αPS integrin
        (Kiger et al., 2007)
        αPS1
        (Negreiros et al., 2010)
        αPS1 integrin
        (Weavers and Skaer, 2013, Zhang and Ten Hagen, 2011, Jattani et al., 2009, Lo, 2006, Ribeiro et al., 2003)
        Secondary FlyBase IDs
        • FBgn0028276
        • FBgn0040161
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (266)