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Gene Dmel\Pk17E

General Information
Symbol	Dmel\Pk17E	Species	D. melanogaster
Name	Protein kinase-like 17E	Annotation symbol	CG7001
Feature type	protein_coding_gene	FlyBase ID	FBgn0004462
Gene Model Status	Current	Stock availability	16 publicly available
Also Known As	BIN4
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	17D6-17E1	Sequence location	X:18,682,499..18,700,090 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Protein kinase-like 17E is referred to in FlyBase by the symbol Dmel\Pk17E (CG7001, FBgn0004462). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: protein serine/threonine kinase activity. Based on sequence similarity, it is predicted to be involved in the biological process: protein phosphorylation. 18 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine- / dual specificity protein kinase, catalytic domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, adult Malpighian tubules, adult fat body, adult female reproductive system. Comments on Affy2 ProbeSet: ProbeSet 1636695_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Pk17E. Gene sequence location is X:18682499..18700090.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 17D6-17E1   Limits computationally determined from genome sequence between P{EP}Pk17EEP438 and P{EP}EP1597
Experimentally Determined Cytological Location
Cytogenetic map Notes References 17E-17E   (determined by in situ hybridisation)   (Zhu and Hanes, 2000) 17E-17E     (Zhu, 1998.10.2) 17E-17E   (determined by in situ hybridisation)   (Kalderon and Rubin, 1988)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Pk17E for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Pk17E-RA FBtr0074634  NM_080122   2127   483 Pk17E-RB FBtr0307198  NM_001258813   1651   169 Pk17E-RC FBtr0307199  NM_001258814   2121   481
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Pk17E-PA   FBpp0074405   55.4   483   8.96     NP_524861   AAF48886 Pk17E-PB   FBpp0298027   19.4   169   5.63     NP_001245742   AFH07455 Pk17E-PC   FBpp0298028   55.1   481   8.96     NP_001245743   AFH07456
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine- / dual specificity protein kinase, catalytic domain (IPR002290) Protein kinase-like domain (IPR011009)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA264698   AA264891   AA390618   AA390619   AA440233   AA538644   AA816999   AA820216   AA990852   AE014298 AAF48886   AF096866 AAC72971   AE014298 AFH07455   AE014298 AFH07456   AI406231   AI455224   AI513624   AI515197   AQ025502   AQ254752   AY069491 AAL39636   AY231924   BF486226   BF497735   BF500373   BF504091   BG632712   BG633281   BG638379   BG641213   BH900900   BI168433   BI172123   BI215427   BI232880   BI484297   BI486531   BI563433   BI563821   BI566179   BI574204   BI574579   BI575866   BI585803   BI586319   BI588270   BI589324   BI619023   BI620525   BI622506   BI636180   BI641053   BT058024   CL527936   CL528201   CL610127   CO269996   CO281299   CO307962   CO310382   CO314732   CO325712   CO329189   CO340383   CZ482703   CZ482704   CZ488701   CZ488702   EC051495   EC053502   EC079069   EC086451   EC201339   EC210660   EC248743   EC250637   EC258163   ES692313   EV579310   GH751441   GH756351   GH756992   GH771367   GH772443   GH775594   GH776298   GH786541   GH787080   GH790463   GH796354   GH798746   GH801635   GH802302   GH803413   GH806637   GH807323   GH807580   GH809277   GH819235   GH825699   GH830953   GH835515   GH838241   GH843039   GH846274   GH848050   GH855479   GH857451   GH867914   GH870534   GH877236   GH882392   GH889992   GH900803   GH901304   GH904147   GH908535   GH910231   GH910585   GH910675   GH929529   GH930681   GH932440
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VWQ2 O96630
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, adult Malpighian tubules, adult fat body, adult female reproductive system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    59.05 Larval Midgut    56.2 Larval Hindgut    68.9 Larval Malpighian Tubules    70.1 Larval Fat Body    61.1 Larval Salivary Gland    30.7 Larval Trachea    30.375 Larval Carcass    34.125 Adult Head    164.3 Adult Eye    196.525 Adult Brain    59.6 Adult Thoracic-Abdominal Ganglion    61.6 Adult Crop    149 Adult Midgut    79.4 Adult Hindgut    98.2 Adult Malpighian Tubules    177.3 Adult Fat Body    159.5 Adult Salivary Gland    51.6 Adult Heart    94.25 Adult VirginFemale Spermatheca    127.8 Adult InseminatedFemale Spermatheca    165.1 Adult Ovary    311.5 Adult Testis    43.5 Adult Male Accessory Gland    34.6 Adult Carcass    89.6 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    59.05 Larval Midgut    56.2 Larval Hindgut    68.9 Larval Malpighian Tubules    70.1 Larval Fat Body    61.1 Larval Salivary Gland    30.7 Larval Trachea    30.375 Larval Carcass    34.125 Adult Head    164.3 Adult Eye    196.525 Adult Brain    59.6 Adult Thoracic-Abdominal Ganglion    61.6 Adult Crop    149 Adult Midgut    79.4 Adult Hindgut    98.2 Adult Malpighian Tubules    177.3 Adult Fat Body    159.5 Adult Salivary Gland    51.6 Adult Heart    94.25 Adult VirginFemale Spermatheca    127.8 Adult InseminatedFemale Spermatheca    165.1 Adult Ovary    311.5 Adult Testis    43.5 Adult Male Accessory Gland    34.6 Adult Carcass    89.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    59.05 Larval Midgut    56.2 Larval Hindgut    68.9 Larval Malpighian Tubules    70.1 Larval Fat Body    61.1 Larval Salivary Gland    30.7 Larval Trachea    30.375 Larval Carcass    34.125 Adult Head    164.3 Adult Eye    196.525 Adult Brain    59.6 Adult Thoracic-Abdominal Ganglion    61.6 Adult Crop    149 Adult Midgut    79.4 Adult Hindgut    98.2 Adult Malpighian Tubules    177.3 Adult Fat Body    159.5 Adult Salivary Gland    51.6 Adult Heart    94.25 Adult VirginFemale Spermatheca    127.8 Adult InseminatedFemale Spermatheca    165.1 Adult Ovary    311.5 Adult Testis    43.5 Adult Male Accessory Gland    34.6 Adult Carcass    89.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    59.05 Larval Midgut    56.2 Larval Hindgut    68.9 Larval Malpighian Tubules    70.1 Larval Fat Body    61.1 Larval Salivary Gland    30.7 Larval Trachea    30.375 Larval Carcass    34.125 Adult Head    164.3 Adult Eye    196.525 Adult Brain    59.6 Adult Thoracic-Abdominal Ganglion    61.6 Adult Crop    149 Adult Midgut    79.4 Adult Hindgut    98.2 Adult Malpighian Tubules    177.3 Adult Fat Body    159.5 Adult Salivary Gland    51.6 Adult Heart    94.25 Adult VirginFemale Spermatheca    127.8 Adult InseminatedFemale Spermatheca    165.1 Adult Ovary    311.5 Adult Testis    43.5 Adult Male Accessory Gland    34.6 Adult Carcass    89.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    59.05 Larval Midgut    56.2 Larval Hindgut    68.9 Larval Malpighian Tubules    70.1 Larval Fat Body    61.1 Larval Salivary Gland    30.7 Larval Trachea    30.375 Larval Carcass    34.125 Adult Head    164.3 Adult Eye    196.525 Adult Brain    59.6 Adult Thoracic-Abdominal Ganglion    61.6 Adult Crop    149 Adult Midgut    79.4 Adult Hindgut    98.2 Adult Malpighian Tubules    177.3 Adult Fat Body    159.5 Adult Salivary Gland    51.6 Adult Heart    94.25 Adult VirginFemale Spermatheca    127.8 Adult InseminatedFemale Spermatheca    165.1 Adult Ovary    311.5 Adult Testis    43.5 Adult Male Accessory Gland    34.6 Adult Carcass    89.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    59.05 Larval Midgut    56.2 Larval Hindgut    68.9 Larval Malpighian Tubules    70.1 Larval Fat Body    61.1 Larval Salivary Gland    30.7 Larval Trachea    30.375 Larval Carcass    34.125 Adult Head    164.3 Adult Eye    196.525 Adult Brain    59.6 Adult Thoracic-Abdominal Ganglion    61.6 Adult Crop    149 Adult Midgut    79.4 Adult Hindgut    98.2 Adult Malpighian Tubules    177.3 Adult Fat Body    159.5 Adult Salivary Gland    51.6 Adult Heart    94.25 Adult VirginFemale Spermatheca    127.8 Adult InseminatedFemale Spermatheca    165.1 Adult Ovary    311.5 Adult Testis    43.5 Adult Male Accessory Gland    34.6 Adult Carcass    89.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    59.05 Larval Midgut    56.2 Larval Hindgut    68.9 Larval Malpighian Tubules    70.1 Larval Fat Body    61.1 Larval Salivary Gland    30.7 Larval Trachea    30.375 Larval Carcass    34.125 Adult Head    164.3 Adult Eye    196.525 Adult Brain    59.6 Adult Thoracic-Abdominal Ganglion    61.6 Adult Crop    149 Adult Midgut    79.4 Adult Hindgut    98.2 Adult Malpighian Tubules    177.3 Adult Fat Body    159.5 Adult Salivary Gland    51.6 Adult Heart    94.25 Adult VirginFemale Spermatheca    127.8 Adult InseminatedFemale Spermatheca    165.1 Adult Ovary    311.5 Adult Testis    43.5 Adult Male Accessory Gland    34.6 Adult Carcass    89.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    59.05 Larval Midgut    56.2 Larval Hindgut    68.9 Larval Malpighian Tubules    70.1 Larval Fat Body    61.1 Larval Salivary Gland    30.7 Larval Trachea    30.375 Larval Carcass    34.125 Adult Head    164.3 Adult Eye    196.525 Adult Brain    59.6 Adult Thoracic-Abdominal Ganglion    61.6 Adult Crop    149 Adult Midgut    79.4 Adult Hindgut    98.2 Adult Malpighian Tubules    177.3 Adult Fat Body    159.5 Adult Salivary Gland    51.6 Adult Heart    94.25 Adult VirginFemale Spermatheca    127.8 Adult InseminatedFemale Spermatheca    165.1 Adult Ovary    311.5 Adult Testis    43.5 Adult Male Accessory Gland    34.6 Adult Carcass    89.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    164.3   NA  Eye    196.525   NA  Brain    59.6   59.05  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    61.6   NA  Crop    149   56.2  Midgut    79.4   68.9  Hindgut    98.2   70.1  Malpighian Tubules    177.3   61.1  Fat Body    159.5   30.7  Salivary Gland    51.6   NA  Heart    94.25   30.375  Trachea    NA   NA  VirginFemale Spermatheca    127.8   NA  InseminatedFemale Spermatheca    165.1   NA  Ovary    311.5   NA  Testis    43.5   NA  Male Accessory Gland    34.6   34.125  Carcass    89.6 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    13 central nervous system, pupae P8    13 head, virgin 1-day female    19 head, virgin 4-day female    21 head, virgin 20-day female    21 head, mated 1-day female    23 head, mated 4-day female    24 head, mated 20-day female    15 head, mated 1-day male    29 head, mated 4-day male    28 head, mated 20-day male    31 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    14 digestive system, 4-day adult    16 digestive system, 20-day adult    15 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    5 carcass, larvae L3 wandering    14 carcass, 1-day adult    12 carcass, 4-day adult    12 carcass, 20-day adult    15 ovary, virgin 4-day female    48 ovary, mated 4-day female    52 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    13 central nervous system, pupae P8    13 head, virgin 1-day female    19 head, virgin 4-day female    21 head, virgin 20-day female    21 head, mated 1-day female    23 head, mated 4-day female    24 head, mated 20-day female    15 head, mated 1-day male  (29) head, mated 4-day male  (28) head, mated 20-day male  (31) salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    12 digestive system, larvae L3 wandering  (30) digestive system, 1-day adult    14 digestive system, 4-day adult    16 digestive system, 20-day adult    15 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    5 carcass, larvae L3 wandering    14 carcass, 1-day adult    12 carcass, 4-day adult    12 carcass, 20-day adult    15 ovary, virgin 4-day female  (48) ovary, mated 4-day female  (52) testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    13 central nervous system, pupae P8    13 head, virgin 1-day female    19 head, virgin 4-day female    21 head, virgin 20-day female    21 head, mated 1-day female    23 head, mated 4-day female    24 head, mated 20-day female    15 head, mated 1-day male    29 head, mated 4-day male    28 head, mated 20-day male    31 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    14 digestive system, 4-day adult    16 digestive system, 20-day adult    15 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    5 carcass, larvae L3 wandering    14 carcass, 1-day adult    12 carcass, 4-day adult    12 carcass, 20-day adult    15 ovary, virgin 4-day female    48 ovary, mated 4-day female    52 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    13 central nervous system, pupae P8    13 head, virgin 1-day female    19 head, virgin 4-day female    21 head, virgin 20-day female    21 head, mated 1-day female    23 head, mated 4-day female    24 head, mated 20-day female    15 head, mated 1-day male    29 head, mated 4-day male    28 head, mated 20-day male    31 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    14 digestive system, 4-day adult    16 digestive system, 20-day adult    15 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    5 carcass, larvae L3 wandering    14 carcass, 1-day adult    12 carcass, 4-day adult    12 carcass, 20-day adult    15 ovary, virgin 4-day female    48 ovary, mated 4-day female    52 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    13 central nervous system, pupae P8    13 head, virgin 1-day female    19 head, virgin 4-day female    21 head, virgin 20-day female    21 head, mated 1-day female    23 head, mated 4-day female    24 head, mated 20-day female    15 head, mated 1-day male    29 head, mated 4-day male    28 head, mated 20-day male    31 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    14 digestive system, 4-day adult    16 digestive system, 20-day adult    15 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    5 carcass, larvae L3 wandering    14 carcass, 1-day adult    12 carcass, 4-day adult    12 carcass, 20-day adult    15 ovary, virgin 4-day female    48 ovary, mated 4-day female    52 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    13 central nervous system, pupae P8    13 head, virgin 1-day female    19 head, virgin 4-day female    21 head, virgin 20-day female    21 head, mated 1-day female    23 head, mated 4-day female    24 head, mated 20-day female    15 head, mated 1-day male  29 head, mated 4-day male  28 head, mated 20-day male  31 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    12 digestive system, larvae L3 wandering  30 digestive system, 1-day adult    14 digestive system, 4-day adult    16 digestive system, 20-day adult    15 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    5 carcass, larvae L3 wandering    14 carcass, 1-day adult    12 carcass, 4-day adult    12 carcass, 20-day adult    15 ovary, virgin 4-day female  (48) ovary, mated 4-day female  (52) testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    13 central nervous system, pupae P8    13 head, virgin 1-day female    19 head, virgin 4-day female    21 head, virgin 20-day female    21 head, mated 1-day female    23 head, mated 4-day female    24 head, mated 20-day female    15 head, mated 1-day male    29 head, mated 4-day male    28 head, mated 20-day male    31 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    14 digestive system, 4-day adult    16 digestive system, 20-day adult    15 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    5 carcass, larvae L3 wandering    14 carcass, 1-day adult    12 carcass, 4-day adult    12 carcass, 20-day adult    15 ovary, virgin 4-day female    48 ovary, mated 4-day female    52 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    13 central nervous system, pupae P8    13 head, virgin 1-day female    19 head, virgin 4-day female    21 head, virgin 20-day female    21 head, mated 1-day female    23 head, mated 4-day female    24 head, mated 20-day female    15 head, mated 1-day male    29 head, mated 4-day male    28 head, mated 20-day male    31 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    14 digestive system, 4-day adult    16 digestive system, 20-day adult    15 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    5 carcass, larvae L3 wandering    14 carcass, 1-day adult    12 carcass, 4-day adult    12 carcass, 20-day adult    15 ovary, virgin 4-day female    48 ovary, mated 4-day female    52 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    53 embryo 02-04hr    52 embryo 04-06hr    22 embryo 06-08hr    16 embryo 08-10hr    18 embryo 10-12hr    14 embryo 12-14hr    15 embryo 14-16hr    16 embryo 16-18hr    16 embryo 18-20hr    17 embryo 20-22hr    37 embryo 22-24hr    35 larva L1    15 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    15 white prepupae new    16 white prepupae 12hr    13 white prepupae 24hr    11 pupae 2d postWPP    9 pupae 3d postWPP    6 pupae 4d postWPP    14 adult male 01day    15 adult male 05day    14 adult male 30day    13 adult female 01day    27 adult female 05day    37 adult female 30day    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (53) embryo 02-04hr  (52) embryo 04-06hr    22 embryo 06-08hr    16 embryo 08-10hr    18 embryo 10-12hr    14 embryo 12-14hr    15 embryo 14-16hr    16 embryo 16-18hr    16 embryo 18-20hr    17 embryo 20-22hr  (37) embryo 22-24hr  (35) larva L1    15 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    15 white prepupae new    16 white prepupae 12hr    13 white prepupae 24hr    11 pupae 2d postWPP    9 pupae 3d postWPP    6 pupae 4d postWPP    14 adult male 01day    15 adult male 05day    14 adult male 30day    13 adult female 01day  (27) adult female 05day  (37) adult female 30day  (38) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    53 embryo 02-04hr    52 embryo 04-06hr    22 embryo 06-08hr    16 embryo 08-10hr    18 embryo 10-12hr    14 embryo 12-14hr    15 embryo 14-16hr    16 embryo 16-18hr    16 embryo 18-20hr    17 embryo 20-22hr    37 embryo 22-24hr    35 larva L1    15 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    15 white prepupae new    16 white prepupae 12hr    13 white prepupae 24hr    11 pupae 2d postWPP    9 pupae 3d postWPP    6 pupae 4d postWPP    14 adult male 01day    15 adult male 05day    14 adult male 30day    13 adult female 01day    27 adult female 05day    37 adult female 30day    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    53 embryo 02-04hr    52 embryo 04-06hr    22 embryo 06-08hr    16 embryo 08-10hr    18 embryo 10-12hr    14 embryo 12-14hr    15 embryo 14-16hr    16 embryo 16-18hr    16 embryo 18-20hr    17 embryo 20-22hr    37 embryo 22-24hr    35 larva L1    15 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    15 white prepupae new    16 white prepupae 12hr    13 white prepupae 24hr    11 pupae 2d postWPP    9 pupae 3d postWPP    6 pupae 4d postWPP    14 adult male 01day    15 adult male 05day    14 adult male 30day    13 adult female 01day    27 adult female 05day    37 adult female 30day    38 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    53 embryo 02-04hr    52 embryo 04-06hr    22 embryo 06-08hr    16 embryo 08-10hr    18 embryo 10-12hr    14 embryo 12-14hr    15 embryo 14-16hr    16 embryo 16-18hr    16 embryo 18-20hr    17 embryo 20-22hr    37 embryo 22-24hr    35 larva L1    15 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    15 white prepupae new    16 white prepupae 12hr    13 white prepupae 24hr    11 pupae 2d postWPP    9 pupae 3d postWPP    6 pupae 4d postWPP    14 adult male 01day    15 adult male 05day    14 adult male 30day    13 adult female 01day    27 adult female 05day    37 adult female 30day    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (53) embryo 02-04hr  (52) embryo 04-06hr    22 embryo 06-08hr    16 embryo 08-10hr    18 embryo 10-12hr    14 embryo 12-14hr    15 embryo 14-16hr    16 embryo 16-18hr    16 embryo 18-20hr    17 embryo 20-22hr  (37) embryo 22-24hr  (35) larva L1    15 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    15 white prepupae new    16 white prepupae 12hr    13 white prepupae 24hr    11 pupae 2d postWPP    9 pupae 3d postWPP    6 pupae 4d postWPP    14 adult male 01day    15 adult male 05day    14 adult male 30day    13 adult female 01day  27 adult female 05day  (37) adult female 30day  (38) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    53 embryo 02-04hr    52 embryo 04-06hr    22 embryo 06-08hr    16 embryo 08-10hr    18 embryo 10-12hr    14 embryo 12-14hr    15 embryo 14-16hr    16 embryo 16-18hr    16 embryo 18-20hr    17 embryo 20-22hr    37 embryo 22-24hr    35 larva L1    15 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    15 white prepupae new    16 white prepupae 12hr    13 white prepupae 24hr    11 pupae 2d postWPP    9 pupae 3d postWPP    6 pupae 4d postWPP    14 adult male 01day    15 adult male 05day    14 adult male 30day    13 adult female 01day    27 adult female 05day    37 adult female 30day    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    53 embryo 02-04hr    52 embryo 04-06hr    22 embryo 06-08hr    16 embryo 08-10hr    18 embryo 10-12hr    14 embryo 12-14hr    15 embryo 14-16hr    16 embryo 16-18hr    16 embryo 18-20hr    17 embryo 20-22hr    37 embryo 22-24hr    35 larva L1    15 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    15 white prepupae new    16 white prepupae 12hr    13 white prepupae 24hr    11 pupae 2d postWPP    9 pupae 3d postWPP    6 pupae 4d postWPP    14 adult male 01day    15 adult male 05day    14 adult male 30day    13 adult female 01day    27 adult female 05day    37 adult female 30day    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    14 Schneider line 2 Sg4    6 embryonic 1182-4H    22 embryonic GM2    29 embryonic Kc167    11 embryonic S1    12 embryonic S3    8 leg disc CME L1    9 wing disc CME-W2    7 wing disc ML-DmD8    10 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    11 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    7 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    12 ovary fGS/OSS    42 ovary OSC    19 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    14 Schneider line 2 Sg4    6 embryonic 1182-4H    22 embryonic GM2  (29) embryonic Kc167    11 embryonic S1    12 embryonic S3    8 leg disc CME L1    9 wing disc CME-W2    7 wing disc ML-DmD8    10 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    11 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    7 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    12 ovary fGS/OSS  (42) ovary OSC    19 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    14 Schneider line 2 Sg4    6 embryonic 1182-4H    22 embryonic GM2    29 embryonic Kc167    11 embryonic S1    12 embryonic S3    8 leg disc CME L1    9 wing disc CME-W2    7 wing disc ML-DmD8    10 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    11 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    7 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    12 ovary fGS/OSS    42 ovary OSC    19 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    14 Schneider line 2 Sg4    6 embryonic 1182-4H    22 embryonic GM2    29 embryonic Kc167    11 embryonic S1    12 embryonic S3    8 leg disc CME L1    9 wing disc CME-W2    7 wing disc ML-DmD8    10 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    11 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    7 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    12 ovary fGS/OSS    42 ovary OSC    19 ovary OSS    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    14 Schneider line 2 Sg4    6 embryonic 1182-4H    22 embryonic GM2    29 embryonic Kc167    11 embryonic S1    12 embryonic S3    8 leg disc CME L1    9 wing disc CME-W2    7 wing disc ML-DmD8    10 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    11 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    7 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    12 ovary fGS/OSS    42 ovary OSC    19 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    14 Schneider line 2 Sg4    6 embryonic 1182-4H    22 embryonic GM2  29 embryonic Kc167    11 embryonic S1    12 embryonic S3    8 leg disc CME L1    9 wing disc CME-W2    7 wing disc ML-DmD8    10 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    11 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    7 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    12 ovary fGS/OSS  (42) ovary OSC    19 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    14 Schneider line 2 Sg4    6 embryonic 1182-4H    22 embryonic GM2    29 embryonic Kc167    11 embryonic S1    12 embryonic S3    8 leg disc CME L1    9 wing disc CME-W2    7 wing disc ML-DmD8    10 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    11 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    7 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    12 ovary fGS/OSS    42 ovary OSC    19 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    14 Schneider line 2 Sg4    6 embryonic 1182-4H    22 embryonic GM2    29 embryonic Kc167    11 embryonic S1    12 embryonic S3    8 leg disc CME L1    9 wing disc CME-W2    7 wing disc ML-DmD8    10 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    11 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    7 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    12 ovary fGS/OSS    42 ovary OSC    19 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    16 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    35 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    31 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3    35 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    43 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    16 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult  (35) Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult  (31) Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3  (35) Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (43) Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult  (31) Paraquat 10 mM 48 hrs, 4-day adult  (31) Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    16 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    35 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    31 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3    35 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    43 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    16 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    35 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    31 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3    35 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    43 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    16 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    35 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    31 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3    35 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    43 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    16 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult  (35) Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult  31 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3  (35) Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (43) Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult  31 Paraquat 10 mM 48 hrs, 4-day adult  31 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    16 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    35 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    31 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3    35 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    43 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    16 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    35 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    31 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3    35 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    43 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_26
External Data & Images
Linkouts	BDGP expression data • LD21956 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004462 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7001-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable Pk17EEY03103 Pk17EEY06723 Pk17EEY10051 viable, with Scer\GAL4pnr-MD237 Pk17EGD10589 Sterility Allele fertile Pk17EEY03103 Pk17EEY06723 Pk17EEY10051 Other Phenotypes Allele neuroanatomy defective | larval stage, with Scer\GAL4elav-C155 Pk17EEP438 Phenotype manifest in Allele anterior fascicle & synapse, with Scer\GAL4elav-C155 Pk17EEP438
Classical Alleles ( 13 )
For All Classical Alleles Show
Allele of Pk17E Class Mutagen Stocks Known lesion Pk17EEP1563 P-element activity 1 -- Pk17EEP438 P-element activity 1 Yes Pk17EEY03103 P-element activity 1 -- Pk17EEY06723 P-element activity 1 -- Pk17EEY10051 P-element activity 1 -- Pk17Ef00224 piggyBac transposase 1 -- Pk17Ef06062 piggyBac transposase 1 -- Pk17EG1175 P-element activity 1 -- Pk17EKG07192 P-element activity 1 -- Pk17EMI01864 1 -- Pk17E5-HA-2357 0 -- Pk17EGG01162 0 -- Pk17EGG01482 0 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Pk17E Class Mutagen Stocks Known lesion Pk17EGD10589 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Pk17EGL00049 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Pk17EJF03185 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Pk17EKK110315 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Pk17EKK111019 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(1)Exel7464 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10589} NA P{KK110315} NA P{KK111019} NA P{TRiP.GL00049} NA P{TRiP.JF03185} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Pk17EEP438 NA P{EP}Pk17EEP1563 NA P{EP}Pk17EG1175 NA P{EPgy2}Pk17EEY03103 NA P{EPgy2}Pk17EEY06723 NA P{EPgy2}Pk17EEY10051 NA P{Mae-UAS.6.11}Pk17EGG01162 NA P{Mae-UAS.6.11}Pk17EGG01482 NA miscellaneous insertions Mi{MIC}Pk17EMI01864 NA P{RS5}Pk17E5-HA-2357 NA P{SUPor-P}Pk17EKG07192 NA PBac{WH}Pk17Ef00224 NA PBac{WH}Pk17Ef06062 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290 (FlyBase Curators et al., 2004-) protein kinase activity inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290 (FlyBase Curators et al., 2004-) protein serine/threonine kinase activity inferred from sequence or structural similarity (Kalderon and Rubin, 1988, Jin et al., 1997) non-traceable author statement (Zhu, 1998.10.2, Morrison et al., 2000)
Biological Process
CV term Evidence References
protein phosphorylation inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Kalderon and Rubin, 1988, Jin et al., 1997) non-traceable author statement (Morrison et al., 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Pk17E - 14-3-3ζ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - ATPsyn-γ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Aats-asn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Aats-trp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Aprt anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Arf102F anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Arf79F anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Arp2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Arpc2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Arpc3A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Arpc4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Arpc5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - CG10306 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - CG10470 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - CG11266 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - CG11671 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - CG11876 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - CG12262 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - CG12264 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - CG1234 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - CG12404 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - CG13220 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - CG1444 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - CG14969 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - CG15098 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - CG15220 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - CG17691 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - CG18596 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - CG18605 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - CG2064 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - CG3008 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - CG31694 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - CG31739 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - CG32138 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - CG33926 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - CG4169 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - CG4764 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - CG4858 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - CG5604 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - CG5885 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - CG6453 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - CG6701 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - CG6724 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - CG7033 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - CG7580 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - CG8478 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - CG9281 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - CG9662 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - CHIP anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Cand1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Cctγ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Chc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Cp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - DnaJ-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Dp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Dref anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Droj2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Gale anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Gmd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - GstE8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Hsc70-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Hsp22 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Hsp23 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Hsp27 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Hsp68 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Hsp70Aa anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Hsp70Ba anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Iswi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Kap-α3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - KdelR anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Mec2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Nipped-B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Nop56 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Ns1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Nup205 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Nurf-38 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - P32 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Past1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Pp2A-29B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - PpV anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Prosα2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Prosα7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Prosβ6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Prp31 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - R anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Rab5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Rab7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Ranbp9 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Ras64B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Ras85D anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - RpL35A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - RpS10b anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - RpS19a anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Rpn1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Rpn2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Rpt1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Rpt2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Rpt4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Rpt5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Rpt6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Set1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - SmD3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Srp68 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Sucb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Syx7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Tapδ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Tcp-1ζ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Tom70 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - Vap-33-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - alt anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - eIF-2β anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - hyd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - l(1)G0230 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - l(1)G0320 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - mRpL51 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - mahj anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - mt:CoII anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - mts anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - nito anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - nop5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - ox anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - pic anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - porin anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - ref(2)P anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - skpA anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - smt3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - spoon anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - sqh anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - tws anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pk17E - βCop anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Pk17E allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 70027 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0004462 DroID - A comprehensive database of gene and protein interactions. • FBgn0004462 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45970 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • O96630
Orthologs
OrthoDB Orthologs (30) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6XPR1R Dipteran inclusive ortholog search EOG62FSS1 Insect inclusive ortholog search EOG61JX7M Arthropod inclusive ortholog search EOG6GHX4J Metazoa inclusive ortholog search EOG6DC67T
Orthologs in Drosophila Species (EOG6XPR1R)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Pk17E     Drosophila simulans   Dsim\GD17406     Drosophila sechellia   Dsec\GM22914     Drosophila erecta   Dere\GG19184     Drosophila yakuba   Dyak\Pk17E     Drosophila ananassae   Dana\GF19132     Drosophila pseudoobscura pseudoobscura   Dpse\GA22315     Drosophila pseudoobscura pseudoobscura   Dpse\GA22314     Drosophila persimilis   Dper\GL26994     Drosophila willistoni   Dwil\GK10197     Drosophila grimshawi   Dgri\GH12172
Orthologs in non-Drosophila Dipterans (EOG62FSS1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL003022   Anopheles gambiae Malaria mosquito  Agam\AGAP000234   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012463
Orthologs in non-Dipteran Insects (EOG61JX7M)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB53637   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG002352   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14188   Atta cephalotes Leafcutter ant  Acep\ACEP10019   Camponotus floridanus Florida carpenter ant  Cflo\CFLO22832   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18696   Linepithema humile Argentine ant  Lhum\LH10583   Pogonomyrmex barbatus Red harvester ant  Pbar\PB18748   Solenopsis invicta Red fire ant  Sinv\SINV21311   Acyrthosiphon pisum Pea aphid  Apim\ACYPI40062   Bombyx mori Silkmoth  Bmor\BGIBMGA005509   Pediculus humanus Human body louse  Phum\PHUM274860   Tribolium castaneum Red flour beetle  Tcas\TC005465
Orthologs in non-Insect Arthropods (EOG6GHX4J)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_312552   Ixodes scapularis Deer tick  Isca\ISCW019236
Orthologs in non-Arthropod Metazoa (EOG6DC67T)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_019117gn
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 16 )
Bloomington	11447 w1118 P{EP}Pk17EEP1563 14612 y1 P{SUPor-P}Pk17EKG07192 28757 y1 v1; P{TRiP.JF03185}attP2 34253 y1 w* Mi{MIC}Pk17EMI01864 33540 w* P{EP}Pk17EG1175 bnbG1175 16752 y1 w67c23 P{EPgy2}Pk17EEY06723
Harvard	- PBac{WH}Pk17Ef00224 - PBac{WH}Pk17Ef06062
VDRC	v101951 P{KK110315}VIE-260B v102179 P{KK111019}VIE-260B v26006 w1118 P{GD10589}v26006 v47326 w1118 P{GD10589}v47326
	More stocks available...
Genomic Clones ( 2 )
	BACR14D22 BACR25O02 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 106 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD21956
Other clones	DPiM_LD21956 MIP02213 yak-em_Pk17E
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT05377 AT12007 AT15241 AT20458 GH12689 GH23618 GH26460 LD08517 LD09520 LD09650 LD09652 LD14857 LD18221 LD23716 LD45825 LD46922 RE09161 RE14088 RE21826 RE29027 RE67377 RE69973 RH22944 RH24733 RH25477 RH26241 RH29421 RH31735 RH32207 RH34067 RH34542 RH35351 RH49981 RH51688 RH54389 SD12495 SD17777 SD24146
Other clones	39612 70202 74703 118100 190018 194558 214415.57 Dmel_dig_013888_0645_1529 EC051495 EC053502 EK097063 EK156411 EK197314 EK221508 EK237610 EK256304 EK292217 EP10536 LD34781 RC0-DA0008-130700-013-E09 RP003030596 RP003031361 RP003041147 RP003042796 RP003046065 RP003057847 RP003070896 RP003078494 RP003080098 RP003080941 RP003099549 RP003113056 RP003138124 RP003163886 RP003166997 RP003173935 RP003173979 RP003185758 RP003212772 RP003238959 RP003244951 RP003262677 RP003288609 RP003357356 RP003372668 RP003380917 RP003421444 RP003428427 RP003437580 RP003438994 RP003451251 RP003464754 RP003481652 RP003485710 RP003486466 RP003564906 RP003572579 RP003574844 RP003605599 RP003607083 RP003649879 RP003655374 RP003656583 RP003678354
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004462 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45970
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Bin4 CG7001 (Li, 1999.11)
Source for database merge of	Source for merge of: Pk17E Bin4 (Bayraktaroglu, 2000.11.2)
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Identification: as a protein that interacts with the Appl cytoplasmic domain in a yeast two-hybrid assay. (Taru et al., 2002) Identification: Interacts with bcd protein bound to DNA in a modified yeast two-hybrid screen. (Zhu and Hanes, 1998) Isolated from a genomic library using a Pka-C1 probe. (Kalderon and Rubin, 1988) Pk17E may encode a protein kinase. (Kalderon and Rubin, 1988) Gene in D.melanogaster encoding product related (by sequence comparison) to the serine-threonine protein kinases of mammals. Isolated from Drosophila clones obtained with mammalian probes.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080122 NM_001258813 NM_001258814 RefSeq (Proteins) • NP_524861 NP_001245742 NP_001245743 DDBJ / EMBL / GenBank • AA816999 AAC72971 AAF48886 AAL39636 AF096866 AFH07455 AFH07456 AI455224 AQ025502 AQ254752 AY069491 BH900900 CL527936 CL528201 CL610127 CZ482703 CZ482704 CZ488701 CZ488702 Entrez Gene - A searchable database of RefSeq genes. • 45970 UniProtKB/TrEMBL • O96630 Q9VWQ2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine- / dual specificity protein kinase, catalytic domain (IPR002290) Protein kinase-like domain (IPR011009) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD21956
Linkouts
	BioGRID - A database of protein and genetic interactions • 70027 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0004462 DroID - A comprehensive database of gene and protein interactions. • FBgn0004462 DRSC - Results from RNAi screens. • FBgn0004462 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004462 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7001-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004462 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45970 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45970 modMine - Data generated by the modENCODE project. • FBgn0004462 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • O96630
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	3-10 (Kalderon and Rubin, 1988, ) BIN4 (Bjorklund et al., 2006, Morrison et al., 2000) Bin4 (Taru et al., 2002, Kraut et al., 2001, Kraut et al., 2001, Zhu and Hanes, 1998, Jin et al., 1997, ) bin4 (Zhu and Hanes, 2000) CG7001 (Kraut et al., 2001, Morrison et al., 2000, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2011.7.19) Pk17E   pk17e (Mattila et al., 2008) Pk?4
Name Synonym	Bicoid interacting protein 4 (Zhu and Hanes, 1998) Protein kinase-like 17E (Gonsalves et al., 2011)
Secondary FlyBase IDs
	FBgn0024489
References ( 36 )
Generate a list of	All references relating to this gene ( 36 )
List References by type	Research paper  ( 7 ) Supplementary material  ( 6 ) Personal communication to FlyBase  ( 13 ) Abstract  ( 2 ) FlyBase analysis  ( 3 ) Curated genome annotation  ( 2 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 ) Book  ( 1 )
Recent research papers ( 1 )
	Gonsalves et al., 2011, BMC Genomics 12: 475 Genome-wide examination of the transcriptional response to ecdysteroids 20-hydroxyecdysone and ponasterone A in Drosophila melanogaster. [FBrf0216487] Show all research papers ...