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Gene Dmel\Fur1

General Information
Symbol	Dmel\Fur1	Species	D. melanogaster
Name	Furin 1	Annotation symbol	CG10772
Feature type	protein_coding_gene	FlyBase ID	FBgn0004509
Gene Model Status	Current	Stock availability	28 publicly available
Also Known As	dFur1, Furin, dKLIP-1
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	96D2-96E1	Sequence location	3R:21,173,090..21,298,778 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Furin 1 is referred to in FlyBase by the symbol Dmel\Fur1 (CG10772, FBgn0004509). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: serine-type endopeptidase activity. It is reported to be involved in the biological process: proteolysis. 30 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum. It has 7 annotated transcripts and 7 annotated polypeptides. Protein features are: Furin-like repeat; Galactose-binding domain-like; Growth factor, receptor; Peptidase S8, subtilisin, Asp-active site; Peptidase S8, subtilisin, His-active site; Peptidase S8, subtilisin, Ser-active site; Peptidase S8, subtilisin-related; Peptidase S8/S53, subtilisin/kexin/sedolisin; Proprotein convertase, P; Proteinase inhibitor, propeptide. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 and 12-24 hour embryonic stages, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval trachea, adult female reproductive system, larval/adult carcass. Gene sequence location is 3R:21173090..21298778.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Reis et al., 2010, PLoS Genet. 6(11): e1001206 Bellen, 2011.10.25, set956.xml Clones MIP19876 Alleles Fur1[MI02922] Polypeptides Fur1-PG Transcripts Fur1-RG Insertions Mi{MIC}Fur1[MI02922] Sequence features HFA13707 BKN22147 BKN45151 HFA16676
FB2011_10	Alleles Fur1[MI03544] Insertions Mi{MIC}Fur1[MI03544] References Bellen, 2011.9.26, MI948.xml
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 96D2-96E1   Limits computationally determined from genome sequence between P{PZ}Aats-gln05461 and P{EP}EP3354
Experimentally Determined Cytological Location
Cytogenetic map Notes References 96D1-96D2     (Hayflick, 1992.11.23) 96C1-96C2   (determined by in situ hybridisation)   (Spradling et al., 1999) 96C1-6C2   (determined by in situ hybridisation)   (BDGP Project Members, 1994-1999) 96D-96D   (determined by in situ hybridisation)   (Roebroek et al., 1993) 96D1-96D2   (determined by in situ hybridisation)   (Hayflick et al., 1992)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Fur1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.43
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Fur1-RA FBtr0089982  NM_170654   4276   1101 Fur1-RB FBtr0089983  NM_080146   4808   1269 Fur1-RC FBtr0089984  NM_170655   3677   892 Fur1-RD FBtr0089985  NM_170656   3612   892 Fur1-RE FBtr0089986  NM_206571   3698   899 Fur1-RF FBtr0089987  NM_206570   3803   892 Fur1-RG FBtr0310618     1820   285
Additional Transcript Data & Comments
Reported size (kB)	8.4, 6.8, 4.5, 4.0 (northern blot) (Hayflick et al., 1992) 7.6, 6.5, 4.5, 4.0 (northern blot) (Roebroek et al., 1993) 6.5, 4.5, 4.0 (northern blot) (Roebroek et al., 1991)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Fur1-PA   FBpp0089025   121.0   1101   6.71     NP_733102   AAN14051 Fur1-PB   FBpp0089026   138.6   1269   9.82     NP_524885   AAF56464 Fur1-PC   FBpp0089027   97.9   892   8.56     NP_733103   AAF56463 Fur1-PD   FBpp0089028   97.9   892   8.56     NP_733104   AAN14052 Fur1-PE   FBpp0089029   98.8   899   8.56     NP_996294   AAS65216 Fur1-PF   FBpp0089030   97.9   892   8.56     NP_996293   AAS65215 Fur1-PG   FBpp0302738   30.2   285   10.45
Additional Polypeptide Data & Comments
Reported size (kDa)	1101 (aa); 140 (kD observed); 131 (kD predicted) (Hayflick et al., 1992) 1101, 892 (aa) (Roebroek et al., 1993) 899 (aa) (Roebroek et al., 1991)
Comments	The 1269aa Fur1 protein is identical over most of its length to the other Fur1 isoforms but has a unique domain of 377aa inserted near the carboxyl end (called domain X by authors). Its activity as a proprotein processing enzyme was demonstrated in gene transfer experiments, where it is capable of processing the precursor of the βA-chain of activin-A and the precursor of von Willebrand factor to the mature forms. (Roebroek et al., 1993) The 892aa Fur1 protein is identical over most of its length to the other Fur1 isoforms but lacks the inserted domains present near the carboxyl end in the other two isoforms. Its activity as a proprotein processing enzyme was demonstrated in gene transfer experiments, where it is capable of processing the precursor of the βA-chain of activin-A and the precursor of von Willebrand factor to the mature forms. (Roebroek et al., 1993) The 1101aa Fur1 protein is identical over most of its length to the other Fur1 isoforms but has two cysteine-rich regions near the carboxyl end of the protein (called CRR by authors). Its activity as a proprotein processing enzyme was demonstrated in gene transfer experiments, where it is capable of processing the precursor of the βA-chain of activin-A and the precursor of von Willebrand factor to the mature forms. (Roebroek et al., 1993) One of several protein products generated by alternative splicing. (FlyBase, 1992-, FlyBase, 1992-, FlyBase, 1992-, FlyBase, 1992-) When coexpressed with pro-β-NGF, Fur1 protein greatly enhances the endoproteolytic conversion of the precursor to mature β-NGF by cleavage at a -Lys-Arg- doublet. In vitro translation and translocation experiments show that Fur1 protein can be translocated across microsomal membranes. (Hayflick et al., 1992) The 899aa Fur1 protein species was predicted from a composite cDNA sequence from two cDNA clones. (Roebroek et al., 1991)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peptidase S8/S53, subtilisin/kexin/sedolisin (IPR000209) Proprotein convertase, P (IPR002884) Furin-like repeat (IPR006212) Galactose-binding domain-like (IPR008979) Proteinase inhibitor, propeptide (IPR009020) Growth factor, receptor (IPR009030) Peptidase S8, subtilisin-related (IPR015500) Peptidase S8, subtilisin, His-active site (IPR022398) Peptidase S8, subtilisin, Asp-active site (IPR023827) Peptidase S8, subtilisin, Ser-active site (IPR023828) MEROPS - An information resource for peptidases and the proteins that inhibit them • S08.071
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA142265   AA246361   AA264055   AA391261   AA697575   AA697577   AA979419   AE014297 AAF56463   AE014297 AAF56464   AE014297 AAN14051   AE014297 AAN14052   AE014297 AAS65215   AE014297 AAS65216   AI108256   AI260688   AQ026369   AW943207   AY069590 AAL39735   BE975059   BI172959   BI237714   BI238309   BI242945   BI362205   BI364105   BI364730   BI570785   BI570786   BI571331   BI591391   BI633516   BP557553   BP557554   BT025186   BT126002   CA807121   CK661553   CO177472   CO178846   CO179304   CO184583   CO188036   CO189717   CO190214   CO196440   CO262699   CO278563   CO286141   CO286603   CO296958   CO299063   CO300973   CO305533   CO305559   CO313372   CO316407   CO318585   CO320705   CO323766   CO327461   CO337377   CO340327   CO345503   CZ466221   CZ466888   CZ468908   CZ469816   CZ471049   CZ480618   CZ481000   CZ481204   CZ482903   CZ483131   CZ483169   CZ485399   CZ488013   CZ489508   CZ490097   EC051167   EC051677   EC051680   EC053191   EC053699   EC055718   EC059149   EC064406   EC065284   EC065960   EC074657   EC074697   EC081182   EC082010   EC083803   EC088829   EC091060   EC195905   EC198397   EC201304   EC202280   EC204741   EC206866   EC215589   EC218487   EC219758   EC227252   EC234442   EC237159   EC238485   EC241389   EC241390   EC242254   EC258061   EC259259   EC259771   EL874707   EL874708   EL874962   EL874963   EL875069   EL875070   L12368   L12369   L12370 AAA28545   L12370 AAA28546   L12370 AAA28547   L12371   L12372 AAA28548   L12375 AAA28550   L12376 AAA28549   M81431 AAA28467   X59384 CAA42027
UniProtKB/Swiss-Prot	P26016 P30430
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   anal pad   (Hayflick et al., 1992, Roebroek et al., 1993) embryonic/larval hindgut   (Hayflick et al., 1992, Roebroek et al., 1993) oenocyte   (Roebroek et al., 1993) embryonic/larval trachea   (Roebroek et al., 1993) embryonic/larval posterior spiracle   (Roebroek et al., 1993) embryonic/larval pharynx   (Roebroek et al., 1993) antenno-maxillary complex   (Roebroek et al., 1993) tracheal pit   (Roebroek et al., 1993) presumptive embryonic/larval central nervous system | restricted   (Roebroek et al., 1993) central nervous system   (Hayflick et al., 1992) labral segment   (Roebroek et al., 1993) embryonic stage 16   central nervous system | restricted   (Hayflick et al., 1992) adult stage   fat body   (Hayflick et al., 1992) adult brain cortex   (Hayflick et al., 1992) subesophageal ganglion   (Hayflick et al., 1992) adult stage | female   oviduct   (Hayflick et al., 1992) adult stage & oogenesis   oocyte   (Hayflick et al., 1992) follicle cell   (Hayflick et al., 1992) nurse cell   (Hayflick et al., 1992)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0004509    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0004509 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 and 12-24 hour embryonic stages, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0004509 expression level Developmental Stage   Expression Level embryo 00-02hr    2100 embryo 02-04hr    2235 embryo 04-06hr    1716 embryo 06-08hr    1358 embryo 08-10hr    1245 embryo 10-12hr    1367 embryo 12-14hr    1480 embryo 14-16hr    1971 embryo 16-18hr    2014 embryo 18-20hr    3703 embryo 20-22hr    2124 embryo 22-24hr    1909 larva L1    909 larva L2    748 larva L3 12hr old    920 larva L3 puffstage 1-2    546 larva L3 puffstage 3-6    960 larva L3 puffstage 7-9    988 white prepupae new    1460 white prepupae 12hr    1582 white prepupae 24hr    1329 pupae 2d postWPP    1378 pupae 3d postWPP    901 pupae 4d postWPP    1176 adult male 01day    898 adult male 05day    808 adult male 30day    773 adult female 01day    1496 adult female 05day    1533 adult female 30day    1524 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2100) embryo 02-04hr  (2235) embryo 04-06hr  (1716) embryo 06-08hr  (1358) embryo 08-10hr  (1245) embryo 10-12hr  (1367) embryo 12-14hr  (1480) embryo 14-16hr  (1971) embryo 16-18hr  (2014) embryo 18-20hr  (3703) embryo 20-22hr  (2124) embryo 22-24hr  (1909) larva L1  (909) larva L2  (748) larva L3 12hr old  (920) larva L3 puffstage 1-2  (546) larva L3 puffstage 3-6  (960) larva L3 puffstage 7-9  (988) white prepupae new  (1460) white prepupae 12hr  (1582) white prepupae 24hr  (1329) pupae 2d postWPP  (1378) pupae 3d postWPP  (901) pupae 4d postWPP  (1176) adult male 01day  (898) adult male 05day  (808) adult male 30day  (773) adult female 01day  (1496) adult female 05day  (1533) adult female 30day  (1524) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2100) embryo 02-04hr  (2235) embryo 04-06hr  (1716) embryo 06-08hr    1358 embryo 08-10hr    1245 embryo 10-12hr    1367 embryo 12-14hr  1480 embryo 14-16hr  (1971) embryo 16-18hr  (2014) embryo 18-20hr  (3703) embryo 20-22hr  (2124) embryo 22-24hr  (1909) larva L1    909 larva L2    748 larva L3 12hr old    920 larva L3 puffstage 1-2    546 larva L3 puffstage 3-6    960 larva L3 puffstage 7-9    988 white prepupae new  1460 white prepupae 12hr  (1582) white prepupae 24hr    1329 pupae 2d postWPP    1378 pupae 3d postWPP    901 pupae 4d postWPP    1176 adult male 01day    898 adult male 05day    808 adult male 30day    773 adult female 01day  1496 adult female 05day  (1533) adult female 30day  (1524) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2100 embryo 02-04hr    2235 embryo 04-06hr    1716 embryo 06-08hr    1358 embryo 08-10hr    1245 embryo 10-12hr    1367 embryo 12-14hr    1480 embryo 14-16hr    1971 embryo 16-18hr    2014 embryo 18-20hr    3703 embryo 20-22hr    2124 embryo 22-24hr    1909 larva L1    909 larva L2    748 larva L3 12hr old    920 larva L3 puffstage 1-2    546 larva L3 puffstage 3-6    960 larva L3 puffstage 7-9    988 white prepupae new    1460 white prepupae 12hr    1582 white prepupae 24hr    1329 pupae 2d postWPP    1378 pupae 3d postWPP    901 pupae 4d postWPP    1176 adult male 01day    898 adult male 05day    808 adult male 30day    773 adult female 01day    1496 adult female 05day    1533 adult female 30day    1524 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2100 embryo 02-04hr    2235 embryo 04-06hr    1716 embryo 06-08hr    1358 embryo 08-10hr    1245 embryo 10-12hr    1367 embryo 12-14hr    1480 embryo 14-16hr    1971 embryo 16-18hr    2014 embryo 18-20hr    3703 embryo 20-22hr    2124 embryo 22-24hr    1909 larva L1    909 larva L2    748 larva L3 12hr old    920 larva L3 puffstage 1-2    546 larva L3 puffstage 3-6    960 larva L3 puffstage 7-9    988 white prepupae new    1460 white prepupae 12hr    1582 white prepupae 24hr    1329 pupae 2d postWPP    1378 pupae 3d postWPP    901 pupae 4d postWPP    1176 adult male 01day    898 adult male 05day    808 adult male 30day    773 adult female 01day    1496 adult female 05day    1533 adult female 30day    1524 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0004509 expression level Developmental Stage   Expression Level embryo 00-02hr    2100 embryo 02-04hr    2235 embryo 04-06hr    1716 embryo 06-08hr    1358 embryo 08-10hr    1245 embryo 10-12hr    1367 embryo 12-14hr    1480 embryo 14-16hr    1971 embryo 16-18hr    2014 embryo 18-20hr    3703 embryo 20-22hr    2124 embryo 22-24hr    1909 larva L1    909 larva L2    748 larva L3 12hr old    920 larva L3 puffstage 1-2    546 larva L3 puffstage 3-6    960 larva L3 puffstage 7-9    988 white prepupae new    1460 white prepupae 12hr    1582 white prepupae 24hr    1329 pupae 2d postWPP    1378 pupae 3d postWPP    901 pupae 4d postWPP    1176 adult male 01day    898 adult male 05day    808 adult male 30day    773 adult female 01day    1496 adult female 05day    1533 adult female 30day    1524 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2100) embryo 02-04hr  (2235) embryo 04-06hr  (1716) embryo 06-08hr  (1358) embryo 08-10hr  (1245) embryo 10-12hr  (1367) embryo 12-14hr  (1480) embryo 14-16hr  (1971) embryo 16-18hr  (2014) embryo 18-20hr  (3703) embryo 20-22hr  (2124) embryo 22-24hr  (1909) larva L1  (909) larva L2  (748) larva L3 12hr old  (920) larva L3 puffstage 1-2  (546) larva L3 puffstage 3-6  (960) larva L3 puffstage 7-9  (988) white prepupae new  (1460) white prepupae 12hr  (1582) white prepupae 24hr  (1329) pupae 2d postWPP  (1378) pupae 3d postWPP  (901) pupae 4d postWPP  (1176) adult male 01day  (898) adult male 05day  (808) adult male 30day  (773) adult female 01day  (1496) adult female 05day  (1533) adult female 30day  (1524) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  2100 embryo 02-04hr  2235 embryo 04-06hr  1716 embryo 06-08hr    1358 embryo 08-10hr    1245 embryo 10-12hr    1367 embryo 12-14hr  1480 embryo 14-16hr  1971 embryo 16-18hr  2014 embryo 18-20hr  (3703) embryo 20-22hr  2124 embryo 22-24hr  1909 larva L1    909 larva L2    748 larva L3 12hr old    920 larva L3 puffstage 1-2    546 larva L3 puffstage 3-6    960 larva L3 puffstage 7-9    988 white prepupae new  1460 white prepupae 12hr  1582 white prepupae 24hr    1329 pupae 2d postWPP    1378 pupae 3d postWPP    901 pupae 4d postWPP    1176 adult male 01day    898 adult male 05day    808 adult male 30day    773 adult female 01day  1496 adult female 05day  1533 adult female 30day  1524 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2100 embryo 02-04hr    2235 embryo 04-06hr    1716 embryo 06-08hr    1358 embryo 08-10hr    1245 embryo 10-12hr    1367 embryo 12-14hr    1480 embryo 14-16hr    1971 embryo 16-18hr    2014 embryo 18-20hr    3703 embryo 20-22hr    2124 embryo 22-24hr    1909 larva L1    909 larva L2    748 larva L3 12hr old    920 larva L3 puffstage 1-2    546 larva L3 puffstage 3-6    960 larva L3 puffstage 7-9    988 white prepupae new    1460 white prepupae 12hr    1582 white prepupae 24hr    1329 pupae 2d postWPP    1378 pupae 3d postWPP    901 pupae 4d postWPP    1176 adult male 01day    898 adult male 05day    808 adult male 30day    773 adult female 01day    1496 adult female 05day    1533 adult female 30day    1524 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2100 embryo 02-04hr    2235 embryo 04-06hr    1716 embryo 06-08hr    1358 embryo 08-10hr    1245 embryo 10-12hr    1367 embryo 12-14hr    1480 embryo 14-16hr    1971 embryo 16-18hr    2014 embryo 18-20hr    3703 embryo 20-22hr    2124 embryo 22-24hr    1909 larva L1    909 larva L2    748 larva L3 12hr old    920 larva L3 puffstage 1-2    546 larva L3 puffstage 3-6    960 larva L3 puffstage 7-9    988 white prepupae new    1460 white prepupae 12hr    1582 white prepupae 24hr    1329 pupae 2d postWPP    1378 pupae 3d postWPP    901 pupae 4d postWPP    1176 adult male 01day    898 adult male 05day    808 adult male 30day    773 adult female 01day    1496 adult female 05day    1533 adult female 30day    1524 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0004509    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0004509 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval trachea, adult female reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis no informative data Adult Male Accessory Gland     Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_27
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004509 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10772-RB;CG10772-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive Fur1rL205 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 Fur1GD12608 viable Fur1PL00566 Fur1PL00624 Sterility Allele fertile Fur1PL00566 Fur1PL00624 Other Phenotypes Allele body color defective, with Scer\GAL4pnr-MD237 Fur1GD12608 visible, with Scer\GAL4pnr-MD237 Fur1GD12608 Phenotype manifest in Allele mesothoracic tergum, with Scer\GAL4pnr-MD237 Fur1GD12608 trichogen cell, with Scer\GAL4pnr-MD237 Fur1GD12608
Classical Alleles ( 28 )
For All Classical Alleles Show
Allele of Fur1 Class Mutagen Stocks Known lesion Fur1c00133 piggyBac transposase 1 -- Fur1c01098 piggyBac transposase 1 -- Fur1c03946 piggyBac transposase 1 -- Fur1c06874 piggyBac transposase 1 -- Fur1d04883 1 -- Fur1DG09506 1 -- Fur1e02845 piggyBac transposase 1 -- Fur1e03228 piggyBac transposase 1 -- Fur1e03425 piggyBac transposase 1 -- Fur1e04489 1 -- Fur1f00437 piggyBac transposase 1 -- Fur1f00663 piggyBac transposase 1 -- Fur1f00701 piggyBac transposase 1 -- Fur1f02843 piggyBac transposase 1 -- Fur1f05439 piggyBac transposase 1 -- Fur1f06040 1 -- Fur1f06784 piggyBac transposase 1 -- Fur1f07280 piggyBac transposase 1 -- Fur1GS9492 1 Yes Fur1MB06661 1 -- Fur1MI00749 1 -- Fur1MI03544 1 -- Fur1NP4490 1 -- Fur1PL00566 P-element activity 1 -- Fur1PL00624 P-element activity 1 -- Fur1rL205 P-element activity 1 -- Fur1c05249 piggyBac transposase 0 -- Fur1MI02922 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Fur1 Class Mutagen Stocks Known lesion Fur1GD12608 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Fur1JF01855 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Not disrupted in	Df(3R)XTA1 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Disrupted in	Df(3R)Exel6202 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12608} NA P{TRiP.JF01855} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}Fur1MI00749 NA Mi{MIC}Fur1MI02922 NA Mi{MIC}Fur1MI03544 NA P{PTT-GB}CB03489 NA P{wHy}Fur1DG09506 NA PBac{PB}Fur1c00133 NA PBac{PB}Fur1c01098 NA PBac{PB}Fur1c03946 NA PBac{PB}Fur1c05249 NA PBac{PB}Fur1c06874 NA PBac{RB}Fur1e02845 NA PBac{RB}Fur1e03228 NA PBac{RB}Fur1e03425 NA PBac{RB}Fur1e04489 NA PBac{WH}Fur1f00437 NA PBac{WH}Fur1f00663 NA PBac{WH}Fur1f00701 NA PBac{WH}Fur1f02843 NA PBac{WH}Fur1f05439 NA PBac{WH}Fur1f06040 NA PBac{WH}Fur1f06784 NA PBac{WH}Fur1f07280 NA insertion of enhancer trap binary system Mi{ET1}Fur1MB06661 No P{GawB}Fur1NP4490 No PBac{GAL4D,EYFP}Fur1PL00566 No PBac{GAL4D,EYFP}Fur1PL00624 No insertion of enhancer trap P{PZ}Fur1rL205 No insertion of mobile activating element P{GSV6}Fur1GS9492 NA P{XP}Fur1d04883 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function
CV term Evidence References
serine-type endopeptidase activity inferred from direct assay (Hayflick et al., 1992)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
plasma membrane inferred from direct assay AND inferred from sequence or structural similarity with human FURIN AND inferred from sequence or structural similarity with Saccharomyces KEX2 (Hayflick et al., 1992)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
serine-type endopeptidase activity non-traceable author statement (Spradling et al., 1999, Swiss-Prot Project Members, 1992.5.1, Swiss-Prot Project Members, 1993.4.1, Hayflick, 1992.11.23)
Biological Process
CV term Evidence References
proteolysis inferred from electronic annotation with InterPro:IPR000209, InterPro:IPR002884 (FlyBase Curators et al., 2004-) non-traceable author statement (Swiss-Prot Project Members, 1992.5.1, Swiss-Prot Project Members, 1993.4.1)
Cellular Component
CV term Evidence References
Golgi stack non-traceable author statement (Swiss-Prot Project Members, 1993.4.1) integral to Golgi membrane non-traceable author statement (Swiss-Prot Project Members, 1992.5.1) integral to membrane non-traceable author statement (Swiss-Prot Project Members, 1993.4.1) plasma membrane inferred from sequence or structural similarity (Roebroek et al., 1991) inferred from sequence or structural similarity with Fur2 (Roebroek et al., 1993)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Fur1 allele Gene References unspecified pbl (Gregory et al., 2007)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 70692 DroID - A comprehensive database of gene and protein interactions. • FBgn0004509 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 47220
Orthologs
Genome-wide drosophilid orthologs	Dere\GG12249 Dper\GL12507 Dsec\GM17716 Dyak\GE10700
Curated drosophilid orthologs
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL003652-PA Aedes aegypti (mosquito) AGAP001330-PA Anopheles gambiae (mosquito) XP_001121308.1 Apis mellifera (honey bee) BGIBMGA001513-PA Bombyx mori (silk worm) ENSBTAP00000027775 Bos taurus (bovine) CE17654 Caenorhabditis elegans (worm) ENSCAFP00000011663 Canis familiaris (dog) cn12109 Cryptococcus neoformans (yeast-like fungus) CPIJ011701 Culex pipens (mosquito) DDB0190194 Dictyostelium discoideum (amoeba) ENSDARP00000004083 Danio rerio (zebra fish) ENSECAP00000018229 Equus caballus (horse) ENSGACP00000011783 Gymnopilus aculeatus (mushroom) ENSP00000308024 Homo sapiens (human) 224835 Lottia gigantea (owl limpet) 30798 Monocosta brevicollis (choanoflagellate) ENSMMUP00000006801 Macaca mulatta (rhesus monkey) ENSORLP00000014948 Oryzias latipes (japanese killifish) PHUM007931-PA Pediculus humanus (human body louse) 103262 Physcomitrella patens (moss) ENSPPYP00000017493 Pongo pygmaeus (orangutan) ENSPTRP00000029255 Pan troglodytes (chimpanzee) ENSRNOP00000015521 Rattus norvegicus (norway rat) ENSTNIP00000013578 Tetraodon nigroviridis (green spotted pufferfish) ENSXETP00000033759 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • LH24965 ISCW006048 FBgn0228546 FBgn0214013 FBgn0210845 FBgn0189736 FBgn0172624 JGI_V11_126713 JGI_V11_306271 FBgn0248895 FBgn0150113 FBgn0145287 FBgn0126814 FBgn0104541 FBgn0095102 CPIJ011701 BGIBMGA001513 ACYPI007476 GB10437 AGAP001330 AAEL003652 PB23155 PHUM246230 GLEAN_10869
Stocks & Reagents
Stocks Listed in FlyBase ( 28 )
Harvard	- P{XP}Fur1d04883 - PBac{PB}Fur1c00133 - PBac{PB}Fur1c01098 - PBac{PB}Fur1c03946 - PBac{PB}Fur1c06874 - PBac{RB}Fur1e02845 - PBac{RB}Fur1e03228 - PBac{RB}Fur1e03425 - PBac{RB}Fur1e04489 - PBac{WH}Fur1f00437 - PBac{WH}Fur1f00663 - PBac{WH}Fur1f00701
	More stocks available...
Genomic Clones ( 2 )
	BACR03M22 BACR10P10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 89 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP14916 LD33976
Other clones	MIP19876
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH07046 HL02808 HL02810 LD05213 LD07428 LD10475 LP04642 LP21148 RE15672 RE33992 RE34723 RE40454 RE46710 RE49151 RE49902 RH05158 RH05567 RH05568 RH06180 SD27626
Other clones	28852 29736 64310 64890 74302 82464 102228 106737 107611 146183 146217 161101 166215 173263 181395 bs38b06 CK01.55B.E8 CK01.60A.H3 CK01.65D.G9 CK01.73B.A6 CK01.75B.D1 CK01.94C.C10 CK01.102B.G7 CK01.107D.F9 CK01.114A.D6 CK00052 EC28286 EC051167 EC051677 EC051680 EC053191 EC053699 EC055718 EC258061 EC259259 EC259771 EK004447 EK036343 EK044952 EK047323 EK053625 EK057727 EK059013 EK061905 EK063330 EK086128 EK130404 EK174429 EK179816 EK191411 EK215520 EK232447 EK248911 EK248943 EK264855 EK273034 EK287264 EN14408 EP07152 EP10431 EP22161 ESG016b.E21_E09 FGM309H11 IP14816 IP15016 IP15116
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004509 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 47220
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Fur1 CG10772 (Bayraktaroglu, 2000.4.17) Source for merge of: Fur1 l(3)rL205 (Spradling et al., 1999)
Additional comments
Other Comments
	The Fur1 gene encodes structurally different subtilisin-like proprotein processing enzymes with distinct physiological functions. (Roebroek et al., 1993) Cloning, tissue and developmental expression, and endoproteolytic activity of Fur1 is studied. (Hayflick et al., 1992) Isolated from a genomic library using a human furin cDNA as a probe, under reduced stringency conditions. (Roebroek et al., 1991) Fur1 has been cloned and sequenced. (Roebroek et al., 1991)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080146 NM_170654 NM_170655 NM_170656 NM_206570 NM_206571 RefSeq (Proteins) • NP_524885 NP_733102 NP_733103 NP_733104 NP_996293 NP_996294 DDBJ / EMBL / GenBank • AA246361 AA979419 AAA28467 AAA28545 AAA28546 AAA28547 AAA28548 AAA28549 AAA28550 AAF56463 AAF56464 AAL39735 AAN14051 AAN14052 AAS65215 AAS65216 AQ026369 AW943207 AY069590 CAA42027 CZ466221 CZ466888 CZ468908 CZ469816 CZ471049 CZ480618 CZ481000 CZ481204 CZ482903 CZ483131 CZ483169 CZ485399 CZ488013 CZ489508 CZ490097 L12368 L12369 L12370 L12371 L12372 L12375 L12376 M81431 X59384 Entrez Gene - A searchable database of RefSeq genes. • 47220 UniProtKB/Swiss-Prot • P26016 P30430
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Peptidase S8/S53, subtilisin/kexin/sedolisin (IPR000209) Proprotein convertase, P (IPR002884) Furin-like repeat (IPR006212) Galactose-binding domain-like (IPR008979) Proteinase inhibitor, propeptide (IPR009020) Growth factor, receptor (IPR009030) Peptidase S8, subtilisin-related (IPR015500) Peptidase S8, subtilisin, His-active site (IPR022398) Peptidase S8, subtilisin, Asp-active site (IPR023827) Peptidase S8, subtilisin, Ser-active site (IPR023828) MEROPS - An information resource for peptidases and the proteins that inhibit them • S08.071
Linkouts
	BioGRID - A database of protein and genetic interactions • 70692 DroID - A comprehensive database of gene and protein interactions. • FBgn0004509 DRSC - Results from RNAi screens. • FBgn0004509 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004509 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10772-RB;CG10772-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004509 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 47220 InParanoid A subset of ortholog calls from InParanoid. • AAEL003652-PA Aedes aegypti (mosquito) AGAP001330-PA Anopheles gambiae (mosquito) XP_001121308.1 Apis mellifera (honey bee) BGIBMGA001513-PA Bombyx mori (silk worm) ENSBTAP00000027775 Bos taurus (bovine) CE17654 Caenorhabditis elegans (worm) ENSCAFP00000011663 Canis familiaris (dog) cn12109 Cryptococcus neoformans (yeast-like fungus) CPIJ011701 Culex pipens (mosquito) DDB0190194 Dictyostelium discoideum (amoeba) ENSDARP00000004083 Danio rerio (zebra fish) ENSECAP00000018229 Equus caballus (horse) ENSGACP00000011783 Gymnopilus aculeatus (mushroom) ENSP00000308024 Homo sapiens (human) 224835 Lottia gigantea (owl limpet) 30798 Monocosta brevicollis (choanoflagellate) ENSMMUP00000006801 Macaca mulatta (rhesus monkey) ENSORLP00000014948 Oryzias latipes (japanese killifish) PHUM007931-PA Pediculus humanus (human body louse) 103262 Physcomitrella patens (moss) ENSPPYP00000017493 Pongo pygmaeus (orangutan) ENSPTRP00000029255 Pan troglodytes (chimpanzee) ENSRNOP00000015521 Rattus norvegicus (norway rat) ENSTNIP00000013578 Tetraodon nigroviridis (green spotted pufferfish) ENSXETP00000033759 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 47220 modMine - Data generated by the modENCODE project. • FBgn0004509 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • LH24965 ISCW006048 FBgn0228546 FBgn0214013 FBgn0210845 FBgn0189736 FBgn0172624 JGI_V11_126713 JGI_V11_306271 FBgn0248895 FBgn0150113 FBgn0145287 FBgn0126814 FBgn0104541 FBgn0095102 CPIJ011701 BGIBMGA001513 ACYPI007476 GB10437 AGAP001330 AAEL003652 PB23155 PHUM246230 GLEAN_10869
Synonyms & Secondary IDs ( 19 )
Reported As
Symbol Synonym	CG10772 (Fulton et al., 2001, Kurusu et al., 2008, Quinones-Coello, 2007, Perkins et al., 1.15.2009) dFur1 (Jiang et al., 2000) Dfur1 (Roebroek, 1991.5.3, Siekhaus and Fuller, 1999, Roebroek et al., 1995, de Bie et al., 1995, McKay et al., 1995, Roebroek et al., 1993, Roebroek et al., 1991, Künnapuu et al., 2009) dFurin 1 (O'Brien and Taghert, 1998) Dfurin1 (Bruning et al., 2007) dKLIP-1 (Hayflick, 1992.11.23, Sappington and Raikhel, 1998, Hayflick et al., 1992, ) fur1 (Roebroek, 1993.3.25, Roebroek, 1993.3.25, Roebroek, 1993.3.25, Roebroek, 1993.3.15, Roebroek, 1993.3.15, Roebroek, 1993.3.15, Siezen and Leunissen, 1997) Fur1 (Buszczak et al., 2007, Quinones-Coello, 2007, Gauthier and Hewes, 2006, Pospisilik et al., 2010, Wasbrough et al., 2010, Reis et al., 2010) fur-1 (Kurusu et al., 2008) fur1 (Yedvobnick et al., 2001) Furin (Lopez-Schier, 2003, Hewes et al., 2003) furin (Roebroek, 1993.3.15, Artavanis-Tsakonas et al., 1999) Furl (Iida and Akashi, 2000) Klip1   l(3)rL205 (BDGP Project Members, 1994-1999, )
Name Synonym	Dfurin1 (Roebroek et al., 1991) Furin 1 (Gregory et al., 2007, Gauthier and Hewes, 2006) Furin1 (Künnapuu et al., 2007) furin1 (Lake et al., 2009) Furin-like protease (Allman et al., 2002)
Secondary FlyBase IDs
	FBgn0010236 FBgn0024579 FBgn0039334
References ( 71 )
Generate a list of	All references relating to this gene ( 71 )
List References by type	Research paper  ( 28 ) Supplementary material  ( 4 ) Review  ( 5 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 2 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 9 ) Computer file  ( 4 ) Protein sequence record  ( 2 ) Curated genome annotation  ( 2 ) Automatic genome annotation  ( 1 )
Recent research papers ( 3 )
	Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Pospisilik et al., 2010, Cell 140(1): 148--160 Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. [FBrf0212676] Reis et al., 2010, PLoS Genet. 6(11): e1001206 A buoyancy-based screen of Drosophila larvae for fat-storage mutants reveals a role for sir2 in coupling fat storage to nutrient availability. [FBrf0212335] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...