FlyBase Gene Report: Dmel\Ets97D

General Information

Symbol

Dmel\Ets97D

Species

D. melanogaster

Name

Ets at 97D

Annotation Symbol

CG6338

Feature Type

protein_coding_gene

FlyBase ID

FBgn0004510

Gene Model Status

Stock Availability

11 publicly available

Gene Snapshot

Contributions welcome

Other Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Red Book
Interactive Fly

Also Known As

D-elg, Delg, elg

Key Links

Genomic Location

Cytogenetic map

Sequence location

3R:26,910,775..26,912,886 [-]

Recombination map

3-92

RefSeq locus

NT_033777 REGION:26910775..26912886

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables DNA-binding transcription factor activity, RNA polymerase II-specific

inferred from biological aspect of ancestor with PANTHER:PTN000218930

(assigned by GO_Central )

(Gaudet et al., 2011)

enables sequence-specific DNA binding

inferred from electronic annotation with InterPro:IPR000418, InterPro:IPR003118

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (7 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in cellular response to starvation

inferred from mutant phenotype

(Baltzer et al., 2009)

involved_in positive regulation of oxidative phosphorylation

inferred from mutant phenotype

(Tiefenböck et al., 2010)

involved_in positive regulation of transcription by RNA polymerase II

inferred from mutant phenotype

(Tiefenböck et al., 2010)

involved_in regulation of glutamine family amino acid metabolic process

inferred from mutant phenotype

(Baltzer et al., 2009)

involved_in regulation of mitochondrion organization

inferred from mutant phenotype

(Baltzer et al., 2009)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in cell differentiation

inferred from biological aspect of ancestor with PANTHER:PTN000218930

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN000218930

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000218930

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

ETS DOMAIN TRANSCRIPTION FACTORS

Protein Family (UniProt)

Belongs to the ETS family. (Q04688)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

ETS DOMAIN TRANSCRIPTION FACTORS -: The E26 transformation specific (ETS) domain transcription factors are sequence-specific DNA-binding proteins that regulate transcription. These factors are characterized by a conserved 85 amino acid DNA binding ETS domain that binds specifically to purine-rich DNA motif GGAA/T. (Adapted from PMID:11715049 and PMID:9570133).

Protein Function (UniProtKB)

May have a role in germline development.

(UniProt, Q04688)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

tne: tiny eggs

Female sterile. Very small eggs.

Summary (Interactive Fly)

Ets domain transcription factor - homolog of the alpha subunit of mammalian NRF-2/GABP - required for proper expression of most genes encoding mitochondrial proteins - regulator of mitochondrial number and mass - required for proper follicle cell migration, chorion formation, and nurse cell chromosome decondensation

Interactive Fly

Gene Model and Products

Number of Transcripts

2

Number of Unique Polypeptides

2

Please see the JBrowse view of Dmel\Ets97D for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

gene_with_stop_codon_read_through ; SO:0000697

Stop-codon suppression (UGA) postulated; FBrf0216884.

Gene model reviewed during 5.44

Gene model reviewed during 5.48

Sequence Ontology: Class of Gene

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0085088

1858

464

FBtr0330167

1858

484

Additional Transcript Data and Comments

Reported size (kB)

1.8 (northern blot)

(Chen et al., 1992)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

FBpp0084458

52.6

464

4.75

FBpp0303200

55.0

484

4.71

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

135 (aa)

(Lautenberger et al., 1992)

464 (aa); 56 (kD)

(The et al., 1992)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ets97D using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ets97D_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

organism | ubiquitous

(Chen et al., 1992)

primordial germ cell

(Chen et al., 1992)

embryonic stage 8 -- 11

primordial germ cell

(Chen et al., 1992)

posterior midgut primordium

(Chen et al., 1992)

embryonic stage 1 -- 3

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | ubiquitous

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Chen et al., 1992)

Additional Descriptive Data

Ets97D transcripts are expressed during most of development with relatively lower levels during larval stages. Transcripts are present throughout the embryo during germ band extension with slightly higher levels in the pole cells.

(Chen et al., 1992)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Ets97D in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Ets97D

View exonic expression by tissue for Dmel\Ets97D

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0004510

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0004510

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG6338-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6338

Flygut - An atlas of the Drosophila adult midgut

FBgn0004510

Images

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 12 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Ets97D

Transgenic constructs containing regulatory region of Ets97D

Deletions and Duplications ( 7 )

Disrupted in

(Strutt and White, 1994)

(Schulz et al., 1993, Schulz et al., 1993, Tearle and Nusslein-Volhard, 1987)

(Strutt and White, 1994)

Not disrupted in

(Strutt and White, 1994)

(Strutt and White, 1994, Schulz et al., 1993, Tearle and Nusslein-Volhard, 1987)

(Strutt and White, 1994)

(Strutt and White, 1994)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

lethal - all die before end of pupal stage (with Df(3R)ro80b)

Ets97D⁶¹³

partially lethal - majority die, with Scer\GAL4^pnr-MD237

Ets97D^GD4119

Ets97D^tne-1

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Ets97D^GD4119

viable, with Scer\GAL4^tin.CΔ4

Ets97D^GD4119

Sterility

Allele

Ets97D^tne-4.14

female sterile | recessive

Ets97D^tne-1

Other Phenotypes

Allele

developmental rate defective

Ets97D⁶¹³

some die during pupal stage, with Scer\GAL4^pnr-MD237

Ets97D^GD4119

visible, with Scer\GAL4^pnr-MD237

Ets97D^GD4119

Ets97D^+t5.4

Phenotype manifest in

Allele

abdominal segment 2

abdominal segment 3

abdominal segment 4

abdominal segment 5

abdominal segment 6

abdominal segment 7

border follicle cell

Ets97D^tne-1

dorsal appendage

Ets97D^tne-4.14

egg chamber | germline clone

Ets97D^8C5-5

Ets97D⁶¹³

fat body | third instar larval stage (with Df(3R)ro80b)

Ets97D⁶¹³

mitochondrial chromosome

Ets97D⁶¹³

Ets97D⁶¹³

mitochondrion | somatic clone | third instar larval stage

Ets97D^tne-1

mitochondrion | third instar larval stage (with Df(3R)ro80b)

Ets97D⁶¹³

nurse cell & nuclear chromosome

trichogen cell, with Scer\GAL4^pnr-MD237

Ets97D^GD4119

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (15)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

14 of 15

Yes

Yes

3 of 15

No

Yes

2 of 15

No

No

2

2 of 15

No

No

2 of 15

No

No

1

2 of 15

No

No

2 of 15

No

No

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (15)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

14 of 15

Yes

Yes

2 of 15

No

No

2 of 15

No

No

2 of 15

No

No

2 of 15

No

Yes

2 of 15

No

No

2 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Rattus norvegicus (Norway rat) (14)

10 of 13

Yes

Yes

3 of 13

No

Yes

2 of 13

No

No

2 of 13

No

No

2 of 13

No

No

2 of 13

No

No

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

Xenopus tropicalis (Western clawed frog) (11)

8 of 12

Yes

Yes

3 of 12

No

Yes

2 of 12

No

No

2 of 12

No

No

2 of 12

No

No

1 of 12

No

No

1 of 12

No

Yes

1 of 12

No

Yes

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

Danio rerio (Zebrafish) (18)

13 of 15

Yes

Yes

3 of 15

No

Yes

2 of 15

No

Yes

2 of 15

No

No

2 of 15

No

No

2 of 15

No

No

2 of 15

No

No

2 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Drer\LOC100537796

1 of 15

No

No

Caenorhabditis elegans (Nematode, roundworm) (10)

2 of 15

Yes

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190B3Q )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00009160

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Drosophila persimilis

Drosophila willistoni

Drosophila virilis

Drosophila mojavensis

Drosophila grimshawi

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091506UB )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Glossina morsitans

Tsetse fly

Gmor\GMOY011538

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_01312

Mayetiola destructor

Hessian fly

Mdes\Mdes004055

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL009584

Anopheles darlingi

American malaria mosquito

Adar\ADAC006167

Anopheles gambiae

Malaria mosquito

Agam\AGAP004337

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ001680

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W09DK )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA011124

Danaus plexippus

Monarch butterfly

Dple\DPOGS200885-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS200884-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL014879

Apis florea

Little honeybee

Aflo\3772793044

Apis mellifera

Western honey bee

Apis mellifera

Western honey bee

Bombus impatiens

Common eastern bumble bee

Bombus terrestris

Buff-tailed bumblebee

Linepithema humile

Argentine ant

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000046

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000913

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG025128

Dendroctonus ponderosae

Mountain pine beetle

Tribolium castaneum

Red flour beetle

Pediculus humanus

Human body louse

Phum\PHUM368570

Rhodnius prolixus

Kissing bug

Rpro\RPRC012582

Cimex lectularius

Bed bug

Clec\CLEC011481

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI31026

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_09658

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0BBO )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR009301

Ixodes scapularis

Black-legged tick

Isca\ISCW019666

Stegodyphus mimosarum

African social velvet spider

Smim\KFM65975.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur32g01780

Tetranychus urticae

Two-spotted spider mite

Turt\tetur25g01880

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_212860

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0EXE )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000010923

Gallus gallus

Domestic chicken

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (8)

Gene Symbol

Score

Source

Alignment

3 of 10

3 of 10

3 of 10

2 of 10

2 of 10

2 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

GABPA; GA binding protein transcription factor subunit alpha

14 of 15

ETV2; ETS variant transcription factor 2

3 of 15

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

bimolecular fluorescence complementation, fluorescence microscopy

(Bischof et al., 2018)

bimolecular fluorescence complementation, fluorescence microscopy

(Bischof et al., 2018)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Gajewski and Schulz, 1995)

enhanceable

(Tiefenböck et al., 2010)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Baltzer et al., 2009)

suppressible

(Baltzer et al., 2009)

enhanceable

(Tiefenböck et al., 2010)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

68127

DroID - A comprehensive database of gene and protein interactions.

FBgn0004510

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

43236

MIST (protein-protein) - An integrated Molecular Interaction Database

Ets97D

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Transcriptional activation of mitochondrial biogenesis

Genomic Location and Detailed Mapping Data

Chromosome (arm)

3R

Recombination map

3-92

Cytogenetic map

Sequence location

3R:26,910,775..26,912,886 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

97D7-97D7

Limits computationally determined from genome sequence between P{lacW}His2Av^L1602 and P{PZ}sda⁰³⁸⁸⁴

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

97D-97D

(Watson, 1992.8.27)

97D-97D

(determined by in situ hybridisation)

(Chen et al., 1992, Pribyl et al., 1991)

Experimentally Determined Recombination Data

Location

3-92

(FlyBase, 2016)

3-89.3

(Comeron et al., 2012)

3-91

(Tearle and Nusslein-Volhard, 1987)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (11)

38641

w¹¹¹⁸; PBac{Ets97D-GFP.FLAG}VK00037

25795

y¹ v¹; P{TRiP.JF01805}attP2

35749

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01491}attP2

36635

y¹ sc^* v¹ sev²¹; P{TRiP.GL00595}attP40

3290

Dp(1;Y)B^S; ru¹ st¹ e¹ Ets97D^tne-4 ca¹/TM3, Ser¹

F003418

M{UAS-Ets97D.ORF-CC}ZH-21F

F000229

M{UAS-Ets97D.ORF.3xHA.GW}ZH-86Fb

v108936

P{KK101610}VIE-260B

v12633

w¹¹¹⁸; P{GD4119}v12633

v12632

w¹¹¹⁸; P{GD4119}v12632/CyO

v341304

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD00356}attP40/CyO-GFP

Genomic Clones (11)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (126)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE06142

Other clones

FI01018

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0004510

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0004510

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

43236

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Additional comments

Other Comments

Identification: in a germline clone screen for mutants that are defective in localisation of an Avic\GFP-stau marker in living oocytes. 1 allele of Ets97D has been identified in the screen.

(Martin et al., 2003)

Ets97D function is required for the correct localisation of the posterior determinants in the oocyte. It is also required for dorsoventral polarity in the follicle cells.

(Gajewski and Schulz, 1995)

Complementation analysis and sequence analysis of the female sterile mutant tiny eggs demonstrates that tiny eggs is an allele of Ets97D. Mutations of Ets97D demonstrate that the Ets97D gene product is required for proper follicle cell migration, chorion formation and nurse cell chromosome decondensation during oogenesis.

(Schulz et al., 1993)

Ets97D has been cloned, sequenced and its RNA expression pattern characterised.

(Chen et al., 1992)

Pattern and mode of coding gene divergence in the ets gene family examined. Results suggest that gene evolution recapitulates species divergence, though at different rates imposed by apparent selective constraints on 3 domains, and that there have been a minimum of 5 ets-primordial gene duplication events: one during X.laevis speciation, one near the time of vertebrate emergence and three prior to the divergence of vertebrates from the Echinodermata and Arthropoda.

(Lautenberger et al., 1992)

Isolated from a pupal cDNA library using pnt and viral ets gene fragments as probes, under low stringency conditions.

(Pribyl et al., 1991)

An Ets97D cDNA has been cloned and sequenced, and Ets97D mRNA expression has been analysed.

(Pribyl et al., 1991)

Origin and Etymology

Discoverer

Anderson.

Etymology

Identification

External Crossreferences and Linkouts ( 45 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43236

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q04688

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

A0A0B4KHY6

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0004510

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0004510

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ets97D_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6338

Flygut - An atlas of the Drosophila adult midgut

FBgn0004510

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

43236

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC033444

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG6338

modMine - A data warehouse for the modENCODE project

FBgn0004510

Linkouts

BioGRID - A database of protein and genetic interactions.

68127

DroID - A comprehensive database of gene and protein interactions.

FBgn0004510

DRSC - Results frm RNAi screens

FBgn0004510

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0004510

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG6338-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0004510

FlyMine - An integrated database for Drosophila genomics

FBgn0004510

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

43236

MIST (protein-protein) - An integrated Molecular Interaction Database

Ets97D

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Transcriptional activation of mitochondrial biogenesis

Synonyms and Secondary IDs (17)

Reported As

Symbol Synonym

CG6338

(Hosono et al., 2015, Fukuoh et al., 2014, Ni et al., 2011.7.19, Baltzer et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009.1.15)

D-Elg

(Chen et al., 1992)

D-elg

(Martin et al., 2003, Hsu and Schulz, 2000, Gajewski and Schulz, 1995, Gajewski and Schulz, 1995, Strutt and White, 1994, Chen, 1993.1.9, Schulz et al., 1993, The et al., 1992, Pribyl et al., 1991)

DELG

(Wasylyk et al., 1993)

Delg

(Sênos Demarco et al., 2019, Tain et al., 2017, Banerjee et al., 2013, Tiefenböck et al., 2010, Baltzer et al., 2009, V.Mirouse and St Johnston, 2007)

Elg

Ets

(Guruharsha et al., 2004)

Ets97D

(Sigalova et al., 2020, Bischof et al., 2018, Schertel et al., 2015, Ugrankar et al., 2015, Chen et al., 2012, Spokony and White, 2012.5.22, Jungreis et al., 2011, Weake et al., 2011, Xing et al., 2007, Zhang et al., 2007, Pickeral et al., 2000)

d-elg

(Baltzer et al., 2007)

delg

(Edenharter et al., 2018, Constantinou et al., 2016, Chartier et al., 2015, Tiefenböck et al., 2010, Baltzer et al., 2009)

elg

(Price and Lai, 1999, Watson, 1992.8.27)

tne

tny

(Tearle and Nusslein-Volhard, 1987)

Name Synonyms

Ets at 97D

(Xing et al., 2007)

Ets like gene

(Baltzer et al., 2009)

tiny

(Tearle and Nusslein-Volhard, 1987)

tiny eggs

Secondary FlyBase IDs

FBgn0003727

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (70)