D-elg, Delg, elg
Ets domain transcription factor - homolog of the alpha subunit of mammalian NRF-2/GABP - required for proper expression of most genes encoding mitochondrial proteins - regulator of mitochondrial number and mass - required for proper follicle cell migration, chorion formation, and nurse cell chromosome decondensation
Please see the GBrowse view of Dmel\Ets97D or the JBrowse view of Dmel\Ets97D for information on other features
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gene_with_stop_codon_read_through ; SO:0000697
Stop-codon suppression (UGA) postulated; FBrf0216884.
Gene model reviewed during 5.44
Gene model reviewed during 5.48
1.8 (northern blot)
None of the polypeptides share 100% sequence identity.
135 (aa)
464 (aa); 56 (kD)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ets97D using the Feature Mapper tool.
Comment: maternally deposited
Ets97D transcripts are expressed during most of development with relatively lower levels during larval stages. Transcripts are present throughout the embryo during germ band extension with slightly higher levels in the pole cells.
GBrowse - Visual display of RNA-Seq signals
View Dmel\Ets97D in GBrowse 23-92
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Ets97D function is required for the correct localisation of the posterior determinants in the oocyte. It is also required for dorsoventral polarity in the follicle cells.
Complementation analysis and sequence analysis of the female sterile mutant tiny eggs demonstrates that tiny eggs is an allele of Ets97D. Mutations of Ets97D demonstrate that the Ets97D gene product is required for proper follicle cell migration, chorion formation and nurse cell chromosome decondensation during oogenesis.
Ets97D has been cloned, sequenced and its RNA expression pattern characterised.
Pattern and mode of coding gene divergence in the ets gene family examined. Results suggest that gene evolution recapitulates species divergence, though at different rates imposed by apparent selective constraints on 3 domains, and that there have been a minimum of 5 ets-primordial gene duplication events: one during X.laevis speciation, one near the time of vertebrate emergence and three prior to the divergence of vertebrates from the Echinodermata and Arthropoda.
Isolated from a pupal cDNA library using pnt and viral ets gene fragments as probes, under low stringency conditions.
Anderson.
