FlyBase Gene Report: Dmel\Mdr49

General Information

Symbol

Dmel\Mdr49

Species

D. melanogaster

Name

Multi drug resistance 49

Annotation Symbol

CG3879

Feature Type

protein_coding_gene

FlyBase ID

FBgn0004512

Gene Model Status

Current

Stock Availability

8 publicly available

Enzyme Name (EC)

Adenosinetriphosphatase (3.6.1.3)

ABC-type xenobiotic transporter (7.6.2.2)

Gene Snapshot

Multi drug resistance 49 (Mdr49) encodes drug transmembrane transporter that belongs to the ABCB transporter subfamily and contributes to insecticide resistance. [Date last reviewed: 2018-09-06]

Other Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Mes5

Key Links

Genomic Location

Cytogenetic map

49E1-49E4

Sequence location

2R:12,940,323..12,946,347 [-]

Recombination map

2-67

RefSeq locus

NT_033778 REGION:12940323..12946347

Sequence

Get Decorated FASTA

Genomic Maps

GBrowse JBrowse

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Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

[Detailed GO annotations]

Gene Group (FlyBase)

ABCB ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY - FULL TRANSPORTERS

Protein Family (UniProt)

Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. (Q00449)

Protein Signatures (InterPro)

Molecular Function (GO)
[Detailed GO annotations]

Experimental Evidence

Predictions / Assertions

ATP binding; ATPase activity; ATPase-coupled transmembrane transporter activity; ATPase-coupled xenobiotic transmembrane transporter activity; efflux transmembrane transporter activity; xenobiotic transmembrane transporter activity

Catalytic Activity (EC)

Experimental Evidence

Predictions / Assertions

ATP + H(2)O = ADP + phosphate (3.6.1.3)

ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2) (7.6.2.2)

Summaries

Gene Group (FlyBase)

ABCB ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY - FULL TRANSPORTERS -: The ATP-binding cassette (ABC) transporter family are primary active transporters that use ATP hydrolysis to drive the transport of substrates across the membrane. The ABCB full transporters encode the functional transporter in one polypeptide. (Adapted from FBrf0224053).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\Mdr49 or the JBrowse view of Dmel\Mdr49 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Mdr49-RA

FBtr0087801

NM_079000

4240

1302

Mdr49-RB

FBtr0302198

NM_001169661

3624

1101

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Mdr49-PA

FBpp0086914

142.7

1302

6.69

NP_523724

AAF58437

Mdr49-PB

FBpp0291408

120.6

1101

7.21

NP_001163132

ACZ94407

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mdr49 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Gene Ontology (17 terms)

Molecular Function (6 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (6 terms)

CV Term

Evidence

References

ATP binding

inferred from electronic annotation with InterPro:IPR003439, InterPro:IPR011527, InterPro:IPR017871

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

ATPase activity

inferred from electronic annotation with InterPro:IPR003439, InterPro:IPR017871

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

ATPase-coupled transmembrane transporter activity

inferred from biological aspect of ancestor with PANTHER:PTN000657189

(assigned by GO_Central )

(Gaudet et al., 2011)

ATPase-coupled xenobiotic transmembrane transporter activity

inferred from sequence or structural similarity with UniProtKB:Q00748

(FlyBase Curators, 2008--)

efflux transmembrane transporter activity

inferred from sequence or structural similarity with UniProtKB:Q00748

(FlyBase Curators, 2008--)

xenobiotic transmembrane transporter activity

non-traceable author statement

(assigned by UniProt )

(Wu et al., 1991)

Biological Process (8 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

germ cell migration

inferred from mutant phenotype

(Ricardo and Lehmann, 2009)

renal tubular secretion

inferred from expression pattern

(Chahine and O'Donnell, 2009)

response to hypoxia

inferred from expression pattern

(Azad et al., 2009)

inferred from mutant phenotype

(Azad et al., 2009)

response to insecticide

inferred from mutant phenotype

(Denecke et al., 2017)

response to toxic substance

inferred from expression pattern

(Chahine and O'Donnell, 2009)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

drug transmembrane transport

non-traceable author statement

(assigned by UniProt )

(Wu et al., 1991)

transmembrane transport

inferred from biological aspect of ancestor with PANTHER:PTN000657189

(assigned by GO_Central )

(Gaudet et al., 2011)

xenobiotic transport

inferred from sequence or structural similarity with UniProtKB:Q00748

(FlyBase Curators, 2008--)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

ATP-binding cassette (ABC) transporter complex

inferred from sequence or structural similarity with UniProtKB:Q00748

(FlyBase Curators, 2008--)

integral component of plasma membrane

non-traceable author statement

(assigned by UniProt )

(Wu et al., 1991)

plasma membrane

inferred from sequence or structural similarity with UniProtKB:Q00748

(FlyBase Curators, 2008--)

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 5

mesoderm anlage

(Stathopoulos et al., 2002)

embryonic stage 4 -- 6

anterior endoderm anlage