FB2020_02, released Apr 14, 2020

Gene: Dmel\Mdr49

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General Information
Symbol
Dmel\Mdr49
Species
D. melanogaster
Name
Multi drug resistance 49
Annotation Symbol
CG3879
Feature Type
protein_coding_gene
FlyBase ID
FBgn0004512
Gene Model Status
Current
Stock Availability
8 publicly available
Enzyme Name (EC)
Adenosinetriphosphatase (3.6.1.3)
ABC-type xenobiotic transporter (7.6.2.2)
Gene Snapshot
Multi drug resistance 49 (Mdr49) encodes drug transmembrane transporter that belongs to the ABCB transporter subfamily and contributes to insecticide resistance. [Date last reviewed: 2018-09-06]
Other Summaries
Also Known As

Mes5

Key Links
Genomic Location
Cytogenetic map
49E1-49E4
Sequence location
2R:12,940,323..12,946,347 [-]
Recombination map

2-67

RefSeq locus
NT_033778 REGION:12940323..12946347
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. (Q00449)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
-
Predictions / Assertions
ATP binding; ATPase activity; ATPase-coupled transmembrane transporter activity; ATPase-coupled xenobiotic transmembrane transporter activity; efflux transmembrane transporter activity; xenobiotic transmembrane transporter activity
Catalytic Activity (EC)
Experimental Evidence
-
Predictions / Assertions
ATP + H(2)O = ADP + phosphate (3.6.1.3)
ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2) (7.6.2.2)
Summaries
Gene Group (FlyBase)
ABCB ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY - FULL TRANSPORTERS -
The ATP-binding cassette (ABC) transporter family are primary active transporters that use ATP hydrolysis to drive the transport of substrates across the membrane. The ABCB full transporters encode the functional transporter in one polypeptide. (Adapted from FBrf0224053).
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\Mdr49 or the JBrowse view of Dmel\Mdr49 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Mdr49-RA
FBtr0087801
NM_079000
4240
1302
Mdr49-RB
FBtr0302198
NM_001169661
3624
1101
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Mdr49-PA
FBpp0086914
142.7
1302
6.69
NP_523724
AAF58437
Mdr49-PB
FBpp0291408
120.6
1101
7.21
NP_001163132
ACZ94407
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mdr49 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (17 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
ATP binding
inferred from electronic annotation with InterPro:IPR003439, InterPro:IPR011527, InterPro:IPR017871
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
ATPase activity
inferred from electronic annotation with InterPro:IPR003439, InterPro:IPR017871
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
ATPase-coupled transmembrane transporter activity
inferred from biological aspect of ancestor with PANTHER:PTN000657189
(assigned by GO_Central )
(Gaudet et al., 2011)
ATPase-coupled xenobiotic transmembrane transporter activity
inferred from sequence or structural similarity with UniProtKB:Q00748
(FlyBase Curators, 2008--)
efflux transmembrane transporter activity
inferred from sequence or structural similarity with UniProtKB:Q00748
(FlyBase Curators, 2008--)
xenobiotic transmembrane transporter activity
non-traceable author statement
(assigned by UniProt )
(Wu et al., 1991)
Biological Process (8 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
germ cell migration
inferred from mutant phenotype
(Ricardo and Lehmann, 2009)
renal tubular secretion
inferred from expression pattern
(Chahine and O'Donnell, 2009)
response to hypoxia
inferred from expression pattern
(Azad et al., 2009)
inferred from mutant phenotype
(Azad et al., 2009)
response to insecticide
inferred from mutant phenotype
(Denecke et al., 2017)
response to toxic substance
inferred from expression pattern
(Chahine and O'Donnell, 2009)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
drug transmembrane transport
non-traceable author statement
(assigned by UniProt )
(Wu et al., 1991)
transmembrane transport
inferred from biological aspect of ancestor with PANTHER:PTN000657189
(assigned by GO_Central )
(Gaudet et al., 2011)
xenobiotic transport
inferred from sequence or structural similarity with UniProtKB:Q00748
(FlyBase Curators, 2008--)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
ATP-binding cassette (ABC) transporter complex
inferred from sequence or structural similarity with UniProtKB:Q00748
(FlyBase Curators, 2008--)
integral component of plasma membrane
non-traceable author statement
(assigned by UniProt )
(Wu et al., 1991)
plasma membrane
inferred from sequence or structural similarity with UniProtKB:Q00748
(FlyBase Curators, 2008--)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Mdr49 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 7 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Mdr49
Transgenic constructs containing regulatory region of Mdr49
Deletions and Duplications ( 13 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (20)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ABCB4
9 of 15
Yes
No
Hsap\ABCB11
9 of 15
Yes
No
Hsap\ABCB1
8 of 15
No
No
 
Hsap\ABCB5
8 of 15
No
No
Hsap\ABCB8
1 of 15
No
No
Hsap\ABCB10
1 of 15
No
No
Hsap\ABCC1
1 of 15
No
No
 
Hsap\ABCC2
1 of 15
No
No
Hsap\ABCC3
1 of 15
No
No
Hsap\ABCC4
1 of 15
No
No
 
Hsap\ABCC5
1 of 15
No
No
 
Hsap\ABCC6
1 of 15
No
No
Hsap\ABCC8
1 of 15
No
No
Hsap\ABCC9
1 of 15
No
No
Hsap\ABCC10
1 of 15
No
No
Hsap\ABCC11
1 of 15
No
No
Hsap\ABCC12
1 of 15
No
No
Hsap\CFTR
1 of 15
No
No
Hsap\TAP1
1 of 15
No
No
Hsap\TAP2
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (21)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Abcb1b
10 of 15
Yes
Yes
Mmus\Abcb1a
9 of 15
No
No
Mmus\Abcb4
9 of 15
No
No
Mmus\Abcb5
7 of 15
No
No
Mmus\Abcb11
7 of 15
No
No
Mmus\Abcb8
1 of 15
No
No
Mmus\Abcb9
1 of 15
No
Yes
Mmus\Abcb10
1 of 15
No
No
Mmus\Abcc1
1 of 15
No
No
Mmus\Abcc2
1 of 15
No
No
Mmus\Abcc3
1 of 15
No
No
Mmus\Abcc4
1 of 15
No
No
Mmus\Abcc5
1 of 15
No
No
Mmus\Abcc6
1 of 15
No
No
Mmus\Abcc8
1 of 15
No
No
Mmus\Abcc9
1 of 15
No
No
Mmus\Abcc10
1 of 15
No
No
Mmus\Abcc12
1 of 15
No
No
Mmus\Cftr
1 of 15
No
No
Mmus\Tap1
1 of 15
No
No
Mmus\Tap2
1 of 15
No
No
Rattus norvegicus (Norway rat) (20)
Rnor\Abcb1b
8 of 13
Yes
Yes
Rnor\Abcb4
7 of 13
No
No
Rnor\Abcb5
7 of 13
No
Yes
Rnor\Abcb1a
6 of 13
No
Yes
Rnor\Abcb11
6 of 13
No
No
Rnor\Abcb9
1 of 13
No
No
Rnor\Abcb10
1 of 13
No
No
Rnor\Abcc1
1 of 13
No
No
Rnor\Abcc2
1 of 13
No
No
Rnor\Abcc3
1 of 13
No
No
Rnor\Abcc4
1 of 13
No
No
Rnor\Abcc5
1 of 13
No
No
Rnor\Abcc6
1 of 13
No
No
Rnor\Abcc8
1 of 13
No
No
Rnor\Abcc9
1 of 13
No
No
Rnor\Abcc10
1 of 13
No
No
Rnor\Abcc12
1 of 13
No
No
Rnor\LOC103689996
1 of 13
No
No
Rnor\Tap1
1 of 13
No
No
Rnor\Tap2
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (18)
Xtro\LOC100494740
5 of 12
Yes
Yes
Xtro\abcb5
2 of 12
No
Yes
Xtro\LOC100485969
2 of 12
No
Yes
Xtro\LOC100489579
2 of 12
No
Yes
Xtro\LOC100489744
2 of 12
No
Yes
Xtro\LOC100494753
2 of 12
No
Yes
Xtro\LOC100496268
2 of 12
No
No
Xtro\LOC108647865
2 of 12
No
Yes
Xtro\abcb8
1 of 12
No
No
Xtro\abcc1
1 of 12
No
No
Xtro\abcc3
1 of 12
No
No
Xtro\abcc4
1 of 12
No
No
Xtro\abcc6
1 of 12
No
No
Xtro\abcc10
1 of 12
No
No
Xtro\cftr
1 of 12
No
No
Xtro\LOC101732668
1 of 12
No
Yes
Xtro\tap1
1 of 12
No
No
Xtro\tap2
1 of 12
No
No
Danio rerio (Zebrafish) (25)
Drer\abcb4
8 of 15
Yes
No
Drer\abcb5
6 of 15
No
No
Drer\abcb11a
6 of 15
No
No
Drer\abcb11b
6 of 15
No
Yes
Drer\abcb8
1 of 15
No
No
Drer\abcb9
1 of 15
No
No
Drer\abcb10
1 of 15
No
No
Drer\abcc1
1 of 15
No
No
Drer\abcc2
1 of 15
No
No
Drer\abcc4
1 of 15
No
No
Drer\abcc5
1 of 15
No
No
Drer\abcc6a
1 of 15
No
No
Drer\abcc6b.1
1 of 15
No
No
Drer\abcc6b.2
1 of 15
No
No
Drer\abcc8b
1 of 15
No
No
Drer\abcc8
1 of 15
No
No
Drer\abcc9
1 of 15
No
No
Drer\abcc10
1 of 15
No
No
Drer\abcc12
1 of 15
No
No
Drer\abcc13
1 of 15
No
No
Drer\cftr
1 of 15
No
No
Drer\LOC101883977
1 of 15
No
Yes
Drer\tap1
1 of 15
No
No
Drer\tap2a
1 of 15
No
No
Drer\tap2t
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (30)
Cele\pgp-2
11 of 15
Yes
Yes
Cele\pgp-9
9 of 15
No
No
Cele\pgp-1
8 of 15
No
No
Cele\pgp-4
8 of 15
No
Yes
Cele\pgp-5
7 of 15
No
Yes
Cele\pgp-3
6 of 15
No
Yes
Cele\pgp-6
6 of 15
No
Yes
Cele\pgp-7
6 of 15
No
Yes
Cele\pgp-8
6 of 15
No
Yes
Cele\pgp-11
5 of 15
No
No
Cele\pgp-12
5 of 15
No
No
Cele\pgp-13
5 of 15
No
No
Cele\pgp-14
5 of 15
No
No
Cele\pgp-10
4 of 15
No
No
Cele\cft-1
1 of 15
No
No
Cele\haf-1
1 of 15
No
No
Cele\haf-2
1 of 15
No
No
Cele\haf-3
1 of 15
No
No
Cele\haf-4
1 of 15
No
No
Cele\haf-6
1 of 15
No
No
Cele\haf-7
1 of 15
No
No
Cele\haf-8
1 of 15
No
No
Cele\mrp-1
1 of 15
No
No
Cele\mrp-2
1 of 15
No
No
Cele\mrp-3
1 of 15
No
No
Cele\mrp-4
1 of 15
No
No
Cele\mrp-5
1 of 15
No
No
Cele\mrp-6
1 of 15
No
No
Cele\mrp-7
1 of 15
No
No
Cele\mrp-8
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (22)
Atha\ABCB2
9 of 9
Yes
Yes
Atha\PGP10
9 of 9
Yes
Yes
Atha\ABCB1
8 of 9
No
Yes
Atha\ABCB3
8 of 9
No
No
Atha\ABCB4
8 of 9
No
No
Atha\ABCB5
8 of 9
No
No
Atha\ABCB7
8 of 9
No
No
Atha\ABCB9
8 of 9
No
No
Atha\ABCB11
8 of 9
No
No
Atha\ABCB12
8 of 9
No
No
Atha\ABCB13
8 of 9
No
Yes
Atha\ABCB15
8 of 9
No
Yes
Atha\ABCB17
8 of 9
No
Yes
Atha\ABCB19
8 of 9
No
Yes
Atha\ABCB21
8 of 9
No
No
Atha\ABCB14
7 of 9
No
Yes
Atha\ABCB18
7 of 9
No
Yes
Atha\ABCB22
7 of 9
No
Yes
Atha\ABCB16
6 of 9
No
Yes
Atha\ABCB6
3 of 9
No
Yes
Atha\ABCB20
3 of 9
No
Yes
Atha\ABCB29
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (10)
Scer\STE6
7 of 15
Yes
No
 
Scer\BPT1
1 of 15
No
No
Scer\MDL1
1 of 15
No
No
Scer\MDL2
1 of 15
No
No
Scer\NFT1
1 of 15
No
No
Scer\VMR1
1 of 15
No
No
Scer\YBT1
1 of 15
No
No
Scer\YCF1
1 of 15
No
No
Scer\YKR104W
1 of 15
No
No
Scer\YOR1
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (3)
Spom\pmd1
10 of 12
Yes
No
Spom\mam1
3 of 12
No
Yes
Spom\mdl1
1 of 12
No
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190109 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00005769
Drosophila simulans
Dsim\GD25799
Drosophila sechellia
Dsec\GM20322
Drosophila erecta
Dere\GG22536
Drosophila yakuba
Dyak\GE13408
Drosophila ananassae
Dana\GF11993
Drosophila pseudoobscura pseudoobscura
Dpse\GA17746
Drosophila persimilis
Dper\GL10597
Drosophila willistoni
Dwil\GK20875
Drosophila virilis
Dvir\GJ21146
Drosophila mojavensis
Dmoj\GI19571
Drosophila grimshawi
Dgri\GH21602
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500JH )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17010834
Musca domestica
House fly
Mdoa\17010833
Musca domestica
House fly
Mdoa\17005466
Glossina morsitans
Tsetse fly
Gmor\GMOY008705
Glossina morsitans
Tsetse fly
Gmor\GMOY007393
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_00005
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_00004
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_13163
Mayetiola destructor
Hessian fly
Mdes\Mdes007343
Mayetiola destructor
Hessian fly
Mdes\Mdes009295
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL010379
Anopheles darlingi
American malaria mosquito
Adar\ADAC007126
Anopheles gambiae
Malaria mosquito
Agam\AGAP005639
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ016887
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0BCM )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA000724
Bombyx mori
Silkmoth
Bmor\BGIBMGA009452
Bombyx mori
Silkmoth
Bmor\BGIBMGA000725
Bombyx mori
Silkmoth
Bmor\BGIBMGA007494
Danaus plexippus
Monarch butterfly
Dple\DPOGS207748-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS207747-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS207818-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS206135-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS207749-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS207746-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS213261-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL008785
Heliconius melpomene
Postman butterfly
Hmel\HMEL004840
Heliconius melpomene
Postman butterfly
Hmel\HMEL011973
Apis florea
Little honeybee
Aflo\2147508467
Apis mellifera
Western honey bee
Amel\GB55378
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20391
Bombus terrestris
Buff-tailed bumblebee
Bter\15214933
Linepithema humile
Argentine ant
Lhum\LH12477
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000b30
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG021290
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_09994
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_09993
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_01739
Tribolium castaneum
Red flour beetle
Tcas\TC003797
Tribolium castaneum
Red flour beetle
Tcas\TC003402
Pediculus humanus
Human body louse
Phum\PHUM177140
Pediculus humanus
Human body louse
Phum\PHUM261630
Pediculus humanus
Human body louse
Phum\PHUM578820
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_04434
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_08525
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0BAA )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR015362
Strigamia maritima
European centipede
Smar\SMAR011846
Strigamia maritima
European centipede
Smar\SMAR009573
Strigamia maritima
European centipede
Smar\SMAR011622
Ixodes scapularis
Black-legged tick
Isca\ISCW017811
Stegodyphus mimosarum
African social velvet spider
Smim\KFM57755.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM59307.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM72296.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM72297.1
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_347265
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_347264
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0HVA )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcb1_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcb10A
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcb1A
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcb8
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcb9A
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcb10B
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcb1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcb9B
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcb1_3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcb4a
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcb1_4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcb1b
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcb4b
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcb9C
Ciona intestinalis
Vase tunicate
Cint\LOC100184731
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000007058
Ciona intestinalis
Vase tunicate
Cint\LOC100182256
Ciona intestinalis
Vase tunicate
Cint\LOC100184484
Ciona intestinalis
Vase tunicate
Cint\LOC100176183
Ciona intestinalis
Vase tunicate
Cint\LOC100180385
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000018443
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000009135
Gallus gallus
Domestic chicken
Ggal\ABCB11
Gallus gallus
Domestic chicken
Ggal\ABCB1
Gallus gallus
Domestic chicken
Ggal\ABCB10
Gallus gallus
Domestic chicken
Ggal\ABCB1
Gallus gallus
Domestic chicken
Ggal\LOC420606
Gallus gallus
Domestic chicken
Ggal\ABCB9
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (21)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG10226
7 of 10
Mdr50
7 of 10
Mdr65
7 of 10
CG1824
2 of 10
CG3156
2 of 10
ABCB7
1 of 10
CG4562
1 of 10
CG5789
1 of 10
CG7627
1 of 10
CG7806
1 of 10
CG9270
1 of 10
CG10505
1 of 10
CG11898
1 of 10
CG31792
1 of 10
CG31793
1 of 10
Hmt-1
1 of 10
l(2)03659
1 of 10
Mrp4
1 of 10
MRP
1 of 10
rdog
1 of 10
Sur
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 5 )
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    Mdr49HMS00400
    exacerbates  neurodegenerative disease
    modeled by Zzzz\CAG127Q.UAS.Tag:HA
    (Yadav and Tapadia, 2013)
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ABCB4; ATP binding cassette subfamily B member 4
    9 of 15
    171060
    ABCB11; ATP binding cassette subfamily B member 11
    9 of 15
    603201
    ABCB1; ATP binding cassette subfamily B member 1
    8 of 15
    171050
     
    ABCB5; ATP binding cassette subfamily B member 5
    8 of 15
    611785
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Interactions Browser
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Hmgcr
        suppressible
        Mdr49
        (Ricardo and Lehmann, 2009, Ricardo and Lehmann, 2009)
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2R
        Recombination map

        2-67

        Cytogenetic map
        49E1-49E4
        Sequence location
        2R:12,940,323..12,946,347 [-]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        49E1-49E4
        Limits computationally determined from genome sequence between P{PZ}l(2)0142401424 and P{lacW}Psck07834&P{lacW}Su(z)2k06344
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        49E-49F
        (determined by in situ hybridisation)
        (Wu et al., 1991)
        Experimentally Determined Recombination Data
        Location

        2-67

        (FlyBase, 2016)

        2-71.3

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (8)
        Genomic Clones (22)
        cDNA Clones (79)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequences
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of
        Source for database merge of
        Additional comments
        Other Comments

        dsRNA has been made from templates generated with primers directed against this gene.

        (Pilot et al., 2006)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 47 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Synonyms and Secondary IDs (9)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (80)