FlyBase Gene Report: Dmel\Mdr65

General Information

Symbol

Dmel\Mdr65

Species

D. melanogaster

Name

Multi drug resistance 65

Annotation Symbol

CG10181

Feature Type

protein_coding_gene

FlyBase ID

FBgn0004513

Gene Model Status

Current

Stock Availability

5 publicly available

Enzyme Name (EC)

ABC-type xenobiotic transporter (7.6.2.2)

Gene Summary

Multi drug resistance 65 (Mdr65) encodes a member of the MRP/ABCC subfamily of ATP-binding cassette (ABC) transporters. It is involved in humoral/CNS barrier drug exclusion and response to insecticide. [Date last reviewed: 2019-09-12] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Multiple drug resistance 65, P-gp, P-glycoprotein

Key Links

Genomic Location

Cytogenetic map

65A10-65A10

Sequence location

3L:6,240,500..6,245,746 [-]

Recombination map

3-16

RefSeq locus

NT_037436 REGION:6240500..6245746

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables ABC-type xenobiotic transporter activity

inferred from direct assay

(Mayer et al., 2009)

enables efflux transmembrane transporter activity

inferred from direct assay

(Mayer et al., 2009)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables ABC-type xenobiotic transporter activity

inferred from biological aspect of ancestor with PANTHER:PTN007780261

(assigned by GO_Central )

(Gaudet et al., 2011)

enables ATP binding

inferred from electronic annotation with InterPro:IPR003439, InterPro:IPR011527, InterPro:IPR017871

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables ATPase-coupled transmembrane transporter activity

inferred from biological aspect of ancestor with PANTHER:PTN000657189

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (6 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in establishment of glial blood-brain barrier

inferred from direct assay

(Mayer et al., 2009)

involved_in renal tubular secretion

inferred from expression pattern

(Chahine and O'Donnell, 2009)

involved_in response to insecticide

inferred from mutant phenotype

(Denecke et al., 2017)

involved_in response to toxic substance

inferred from expression pattern

(Chahine and O'Donnell, 2009)

involved_in xenobiotic transport

inferred from direct assay

(Mayer et al., 2009)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in transmembrane transport

inferred from biological aspect of ancestor with PANTHER:PTN000657189

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

part_of ATP-binding cassette (ABC) transporter complex

inferred from direct assay

(Mayer et al., 2009)

located_in pleated septate junction

inferred from direct assay

(Mayer et al., 2009)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in integral component of membrane

inferred from biological aspect of ancestor with PANTHER:PTN002517083

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

ABCB ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY - FULL TRANSPORTERS

Protein Family (UniProt)

Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. (Q00748)

Protein Signatures (InterPro)

Catalytic Activity (EC)

Experimental Evidence

ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2) (7.6.2.2)

Predictions / Assertions

ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2) (7.6.2.2)

Summaries

Gene Snapshot

Gene Group (FlyBase)

ABCB ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY - FULL TRANSPORTERS -: The ATP-binding cassette (ABC) transporter family are primary active transporters that use ATP hydrolysis to drive the transport of substrates across the membrane. The ABCB full transporters encode the functional transporter in one polypeptide. (Adapted from FBrf0224053).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Mdr65 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q00748)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Mdr65-RA

FBtr0077011

NM_057483

4135

1302

Additional Transcript Data and Comments

Reported size (kB)

4.124 (longest cDNA)

(Wu et al., 1991)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Mdr65-PA

FBpp0076719

143.8

1302

6.44

Q00748

NP_476831

AAF50669

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

1302 (aa)

(Wu et al., 1991)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mdr65 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Mdr65_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that the Fly Cell Atlas project found the gene expressed in that cell type. Darker colors mean that more cells of that cell type express the gene:

low

high

Colorless tiles indicate that there is no scRNAseq data for the gene in that cell type.

Colored tiles in ribbon indicate that expression data (RNA and/or protein) has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

Colored tiles in the ribbon indicate the average RNA expression level of the gene at the indicated stages:

low

high

as determined by RNA-seq (RPKM) using whole organism samples modENCODE, Brown et al., 2014. For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 13 -- 16

embryonic central brain glial cell

(Fisher et al., 2012)

embryonic central brain surface glia

(Fisher et al., 2012)

lateral cord glial cell

(Fisher et al., 2012)

lateral cord surface glial cell

(Fisher et al., 2012)

ventral midline of embryo

(Fisher et al., 2012)

midline glial cell

(Kearney et al., 2004)

wandering third instar larval stage

embryonic/larval salivary gland

(Tapadia and Lakhotia, 2005)

embryonic/larval brain | restricted

(Tapadia and Lakhotia, 2005)

wing disc | restricted

(Tapadia and Lakhotia, 2005)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

subperineurial glial cell

(Mayer et al., 2009)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Mdr65 protein is localized to the subperineurial glial cells forming the blood-brain barrier.

(Mayer et al., 2009)

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of ATP-binding cassette (ABC) transporter complex

inferred from direct assay

(Mayer et al., 2009)

located_in pleated septate junction

inferred from direct assay

(Mayer et al., 2009)

Expression Deduced from Reporters

Reporter: P{GMR54C07-GAL4}

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- larval stage

embryonic/larval CNS subperineurial glial cell

(Kremer et al., 2017)

third instar larval stage

embryonic/larval CNS subperineurial glial cell

(Spéder and Brand, 2014)

adult stage

subperineurial glial cell

(Hill et al., 2019)

adult brain subperineurial glial cell

(Kremer et al., 2017)

CNS subperineurial glial cell

(Kremer et al., 2017)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Mdr65 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Mdr65

View exonic expression by tissue for Dmel\Mdr65

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0004513

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38726/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0004513

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004513

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0004513

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10181

Flygut - An atlas of the Drosophila adult midgut

FBgn0004513

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Mdr65

Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 4 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Mdr65

Transgenic constructs containing regulatory region of Mdr65

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3L)Exel6108

(Ryder, 2004.4.26)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority live

Mdr65^KO

viable

Mdr65^KO

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Mdr65^GD2330

viable, with Scer\GAL4^Mef2.PR

Mdr65^GD2330

viable, with Scer\GAL4^pnr-MD237

Mdr65^GD2330

viable, with Scer\GAL4^tin.CΔ4

Mdr65^GD2330

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (20)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\ABCB4

11 of 15

Yes

8 of 15

8 of 15

8 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (21)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Abcb4

10 of 15

Yes

8 of 15

8 of 15

6 of 15

6 of 15

2 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (21)

Rnor\Abcb4

8 of 13

Yes

6 of 13

6 of 13

5 of 13

5 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (18)

Xtro\LOC100494740

4 of 12

Yes

Xtro\abcb5

2 of 12

Yes

Xtro\LOC100485969

2 of 12

Yes

Xtro\LOC100489579

2 of 12

Yes

Xtro\LOC100489744

2 of 12

Yes

Xtro\LOC100494753

2 of 12

Yes

Xtro\LOC100496268

2 of 12

Xtro\LOC108647865

2 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Xtro\tap1

1 of 12

Xtro\tap2

1 of 12

Danio rerio (Zebrafish) (25)

Drer\abcb4

7 of 15

Yes

5 of 15

5 of 15

5 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\tap2a

1 of 15

Drer\tap2t

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (30)

Cele\pgp-2

10 of 15

Yes

9 of 15

9 of 15

7 of 15

7 of 15

Yes

Cele\pgp-5

6 of 15

Cele\pgp-6

6 of 15

Yes

Cele\pgp-7

6 of 15

Yes

Cele\pgp-8

6 of 15

Yes

Cele\pgp-11

6 of 15

Yes

Cele\pgp-13

6 of 15

Yes

Cele\pgp-14

6 of 15

Yes

Cele\pgp-3

5 of 15

Cele\pgp-10

5 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Arabidopsis thaliana (thale-cress) (22)

Atha\ABCB1

7 of 9

Yes

Atha\ABCB2

7 of 9

Yes

Atha\ABCB3

7 of 9

Yes

Atha\ABCB4

7 of 9

Yes

Atha\ABCB5

7 of 9

Yes

Atha\ABCB7

7 of 9

Yes

Atha\ABCB9

7 of 9

Yes

Atha\ABCB11

7 of 9

Yes

Atha\ABCB12

7 of 9

Yes

Atha\ABCB13

7 of 9

Yes

Atha\ABCB15

7 of 9

Yes

Atha\ABCB17

7 of 9

Yes

Atha\ABCB19

7 of 9

Yes

Atha\ABCB21

7 of 9

Yes

Atha\PGP10

7 of 9

Yes

Atha\ABCB14

6 of 9

Atha\ABCB16

6 of 9

Yes

Atha\ABCB18

6 of 9

Atha\ABCB22

6 of 9

Atha\ABCB6

3 of 9

Yes

Atha\ABCB20

3 of 9

Yes

Atha\ABCB29

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (10)

Scer\STE6

7 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\pmd1

10 of 12

Yes

Spom\mam1

3 of 12

Yes

Spom\mdl1

1 of 12

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (21)

Gene Symbol

Score

Source

Alignment

7 of 10

7 of 10

7 of 10

2 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

MRP

1 of 10

rdog

1 of 10

Sur

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 3 )

Human Ortholog

Disease

Evidence

References

ABCB4; ATP binding cassette subfamily B member 4

model of cholecystitis

IEA

(FlyBase, 2019-)

model of intrahepatic cholestasis of pregnancy 3

IEA

(FlyBase, 2019-)

model of progressive familial intrahepatic cholestasis 3

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Mdr65^HMS01449

exacerbates neurodegenerative disease

modeled by Zzzz\CAG^{127Q.UAS.Tag:HA}

(Yadav and Tapadia, 2013)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ABCB4; ATP binding cassette subfamily B member 4

11 of 15

171060

ABCB1; ATP binding cassette subfamily B member 1

8 of 15

171050

inflammatory bowel disease 13

ABCB5; ATP binding cassette subfamily B member 5

8 of 15

611785

ABCB11; ATP binding cassette subfamily B member 11

8 of 15

603201

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

eas

suppressible

Mdr65

(Howlett and Tanouye, 2013)

para

suppressible

Mdr65

(Howlett and Tanouye, 2013)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

64179

DroID - A comprehensive database of gene and protein interactions.

FBgn0004513

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0004513

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

ABC transporters

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-16

Cytogenetic map

65A10-65A10

Sequence location

3L:6,240,500..6,245,746 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

65A10-65A10

Limits computationally determined from genome sequence between P{PZ}l(3)02094⁰²⁰⁹⁴ and P{lacW}l(3)L4060^L4060

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-16

(FlyBase, 2016)

3-14.5

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (5)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

28664

y¹ v¹; P{TRiP.JF03079}attP2

30619

y¹ w^*; Mi{MIC}Mdr65^MI00104

35035

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01449}attP2

14757

y¹ w^67c23; P{SUPor-P}Mdr65^KG08723 ry⁵⁰⁶

VDRC

v330546

P{VSH330546}attP40

Genomic Clones (14)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (17)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE14657

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0004513

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0004513

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

38726

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Mayer et al., 2009)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Mdr65 CG10181

(Gabrielian, 1999.11)

Source for database merge of

Additional comments

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 52 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

38726

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q00748

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q00748

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q8MRC4

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q00748

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0004513

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0004513

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38726/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0004513

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Mdr65_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004513

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0004513

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10181

Flygut - An atlas of the Drosophila adult midgut

FBgn0004513

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0004513

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

38726

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG10181

MARRVEL_MODEL - MARRVEL (model organism gene)

38726

modMine - A data warehouse for the modENCODE project

FBgn0004513

Linkouts

BioGRID - A database of protein and genetic interactions.

64179

DroID - A comprehensive database of gene and protein interactions.

FBgn0004513

DRSC - Results frm RNAi screens

FBgn0004513

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0004513

FlyMine - An integrated database for Drosophila genomics

FBgn0004513

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

ABC transporters

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

CG10181

(Meadows, 2018.10.31, Paulsen et al., 2013, Ni et al., 2011.7.19, Khanna et al., 2010, Chahine and O'Donnell, 2009, Perkins et al., 2009)

DmMdr65

(He et al., 2019)

MDR65

(Luo et al., 2013, Chahine and O'Donnell, 2009)

Mdr65

(Byers et al., 2021, Douris et al., 2020, Etges, 2019, Harbison et al., 2019, Trinh et al., 2019, Zhang et al., 2018, Denecke et al., 2017, Hindle et al., 2017, Sun et al., 2017, Kang et al., 2016, Gellatly et al., 2015, DeSalvo et al., 2014, Howlett and Tanouye, 2013, Japanese National Institute of Genetics, 2012.5.21, Mayer et al., 2009)

Mdr65A

(Begun and Whitley, 2000)

P-glycoprotein

(Chen et al., 2016)

P-gp

(Chen et al., 2016, Luo et al., 2013)

mdr65

(Saini et al., 2020, Yadav and Tapadia, 2016, Yadav and Tapadia, 2013, Ricardo and Lehmann, 2009, Ricardo and Lehmann, 2009, Tapadia and Lakhotia, 2005)

Name Synonyms

Multi drug resistance 65

Multiple drug resistance 65

(Khanna et al., 2010)

P-glycoprotein

(Luo et al., 2013)

P-glycoprotein65-Dm

(Nasonkin et al., 1999)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

References (80)

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