FB2020_06, released Dec 22, 2020

Gene: Dmel\Mdr65

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General Information
Symbol
Dmel\Mdr65
Species
D. melanogaster
Name
Multi drug resistance 65
Annotation Symbol
CG10181
Feature Type
protein_coding_gene
FlyBase ID
FBgn0004513
Gene Model Status
Current
Stock Availability
5 publicly available
Gene Snapshot
Multi drug resistance 65 (Mdr65) encodes a member of the MRP/ABCC subfamily of ATP-binding cassette (ABC) transporters. It is involved in humoral/CNS barrier drug exclusion and response to insecticide. [Date last reviewed: 2019-09-12]
Other Summaries
Also Known As

Multiple drug resistance 65, P-glycoprotein, P-gp

Key Links
Genomic Location
Cytogenetic map
65A10-65A10
Sequence location
3L:6,240,500..6,245,746 [-]
Recombination map

3-16

RefSeq locus
NT_037436 REGION:6240500..6245746
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (14 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables ATPase-coupled xenobiotic transmembrane transporter activity
inferred from direct assay
(Mayer et al., 2009)
enables efflux transmembrane transporter activity
inferred from direct assay
(Mayer et al., 2009)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR003439, InterPro:IPR011527, InterPro:IPR017871
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables ATPase activity
inferred from electronic annotation with InterPro:IPR003439, InterPro:IPR017871
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables ATPase-coupled transmembrane transporter activity
inferred from biological aspect of ancestor with PANTHER:PTN000657189
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (6 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in establishment of glial blood-brain barrier
inferred from direct assay
(Mayer et al., 2009)
involved_in renal tubular secretion
inferred from expression pattern
(Chahine and O'Donnell, 2009)
involved_in response to insecticide
inferred from mutant phenotype
(Denecke et al., 2017)
involved_in response to toxic substance
inferred from expression pattern
(Chahine and O'Donnell, 2009)
involved_in xenobiotic transport
inferred from direct assay
(Mayer et al., 2009)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in transmembrane transport
inferred from biological aspect of ancestor with PANTHER:PTN000657189
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
part_of ATP-binding cassette (ABC) transporter complex
inferred from direct assay
(Mayer et al., 2009)
located_in pleated septate junction
inferred from direct assay
(Mayer et al., 2009)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in integral component of membrane
inferred from biological aspect of ancestor with PANTHER:PTN002517083
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. (Q00748)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
ABCB ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY - FULL TRANSPORTERS -
The ATP-binding cassette (ABC) transporter family are primary active transporters that use ATP hydrolysis to drive the transport of substrates across the membrane. The ABCB full transporters encode the functional transporter in one polypeptide. (Adapted from FBrf0224053).
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Mdr65 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Mdr65-RA
FBtr0077011
NM_057483
4135
1302
Additional Transcript Data and Comments
Reported size (kB)

4.124 (longest cDNA)

(Wu et al., 1991)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Mdr65-PA
FBpp0076719
143.8
1302
6.44
NP_476831
AAF50669
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

1302 (aa)

(Wu et al., 1991)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mdr65 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
subperineurial glial cell
(Mayer et al., 2009)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data

Mdr65 protein is localized to the subperineurial glial cells forming the blood-brain barrier.

(Mayer et al., 2009)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of ATP-binding cassette (ABC) transporter complex
inferred from direct assay
(Mayer et al., 2009)
located_in pleated septate junction
inferred from direct assay
(Mayer et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Mdr65 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 4 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Mdr65
Transgenic constructs containing regulatory region of Mdr65
Deletions and Duplications ( 1 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (20)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ABCB4
11 of 15
Yes
Yes
Hsap\ABCB1
8 of 15
No
No
1  
Hsap\ABCB5
8 of 15
No
No
Hsap\ABCB11
8 of 15
No
No
Hsap\ABCB8
2 of 15
No
No
Hsap\ABCB10
1 of 15
No
No
Hsap\ABCC1
1 of 15
No
No
1  
Hsap\ABCC2
1 of 15
No
No
Hsap\ABCC3
1 of 15
No
No
Hsap\ABCC4
1 of 15
No
No
1  
Hsap\ABCC5
1 of 15
No
No
1  
Hsap\ABCC6
1 of 15
No
No
Hsap\ABCC8
1 of 15
No
No
Hsap\ABCC9
1 of 15
No
No
Hsap\ABCC10
1 of 15
No
No
Hsap\ABCC11
1 of 15
No
No
Hsap\ABCC12
1 of 15
No
No
Hsap\CFTR
1 of 15
No
No
10  
Hsap\TAP1
1 of 15
No
No
Hsap\TAP2
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (21)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Abcb4
10 of 15
Yes
Yes
Mmus\Abcb1a
8 of 15
No
No
Mmus\Abcb1b
8 of 15
No
No
Mmus\Abcb5
6 of 15
No
No
Mmus\Abcb11
6 of 15
No
No
Mmus\Abcb8
2 of 15
No
No
Mmus\Abcb9
1 of 15
No
Yes
Mmus\Abcb10
1 of 15
No
No
Mmus\Abcc1
1 of 15
No
No
Mmus\Abcc2
1 of 15
No
No
Mmus\Abcc3
1 of 15
No
No
Mmus\Abcc4
1 of 15
No
No
Mmus\Abcc5
1 of 15
No
No
Mmus\Abcc6
1 of 15
No
No
Mmus\Abcc8
1 of 15
No
No
Mmus\Abcc9
1 of 15
No
No
Mmus\Abcc10
1 of 15
No
No
Mmus\Abcc12
1 of 15
No
No
Mmus\Cftr
1 of 15
No
No
Mmus\Tap1
1 of 15
No
No
Mmus\Tap2
1 of 15
No
No
Rattus norvegicus (Norway rat) (21)
Rnor\Abcb4
8 of 13
Yes
Yes
Rnor\Abcb1b
6 of 13
No
No
Rnor\Abcb5
6 of 13
No
No
Rnor\Abcb1a
5 of 13
No
No
Rnor\Abcb11
5 of 13
No
No
Rnor\Abcb8
1 of 13
No
No
Rnor\Abcb9
1 of 13
No
No
Rnor\Abcb10
1 of 13
No
No
Rnor\Abcc1
1 of 13
No
No
Rnor\Abcc2
1 of 13
No
No
Rnor\Abcc3
1 of 13
No
No
Rnor\Abcc4
1 of 13
No
No
Rnor\Abcc5
1 of 13
No
No
Rnor\Abcc6
1 of 13
No
No
Rnor\Abcc8
1 of 13
No
No
Rnor\Abcc9
1 of 13
No
No
Rnor\Abcc10
1 of 13
No
No
Rnor\Abcc12
1 of 13
No
No
Rnor\LOC103689996
1 of 13
No
No
Rnor\Tap1
1 of 13
No
No
Rnor\Tap2
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (18)
Xtro\LOC100494740
4 of 12
Yes
No
Xtro\abcb5
2 of 12
No
Yes
Xtro\LOC100485969
2 of 12
No
Yes
Xtro\LOC100489579
2 of 12
No
Yes
Xtro\LOC100489744
2 of 12
No
Yes
Xtro\LOC100494753
2 of 12
No
Yes
Xtro\LOC100496268
2 of 12
No
No
Xtro\LOC108647865
2 of 12
No
Yes
Xtro\abcb8
1 of 12
No
No
Xtro\abcc1
1 of 12
No
No
Xtro\abcc3
1 of 12
No
No
Xtro\abcc4
1 of 12
No
No
Xtro\abcc6
1 of 12
No
No
Xtro\abcc10
1 of 12
No
No
Xtro\cftr
1 of 12
No
No
Xtro\LOC101732668
1 of 12
No
Yes
Xtro\tap1
1 of 12
No
No
Xtro\tap2
1 of 12
No
No
Danio rerio (Zebrafish) (25)
Drer\abcb4
7 of 15
Yes
No
Drer\abcb5
5 of 15
No
No
Drer\abcb11a
5 of 15
No
No
Drer\abcb11b
5 of 15
No
No
Drer\abcb8
2 of 15
No
No
Drer\tap1
2 of 15
No
No
Drer\abcb9
1 of 15
No
No
Drer\abcb10
1 of 15
No
No
Drer\abcc1
1 of 15
No
No
Drer\abcc2
1 of 15
No
No
Drer\abcc4
1 of 15
No
No
Drer\abcc5
1 of 15
No
No
Drer\abcc6a
1 of 15
No
No
Drer\abcc6b.1
1 of 15
No
No
Drer\abcc6b.2
1 of 15
No
No
Drer\abcc8b
1 of 15
No
No
Drer\abcc8
1 of 15
No
No
Drer\abcc9
1 of 15
No
No
Drer\abcc10
1 of 15
No
No
Drer\abcc12
1 of 15
No
No
Drer\abcc13
1 of 15
No
No
Drer\cftr
1 of 15
No
No
Drer\LOC101883977
1 of 15
No
Yes
Drer\tap2a
1 of 15
No
No
Drer\tap2t
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (30)
Cele\pgp-2
10 of 15
Yes
No
Cele\pgp-1
9 of 15
No
No
Cele\pgp-9
9 of 15
No
No
Cele\pgp-4
7 of 15
No
No
Cele\pgp-12
7 of 15
No
Yes
Cele\pgp-5
6 of 15
No
No
Cele\pgp-6
6 of 15
No
Yes
Cele\pgp-7
6 of 15
No
Yes
Cele\pgp-8
6 of 15
No
Yes
Cele\pgp-11
6 of 15
No
Yes
Cele\pgp-13
6 of 15
No
Yes
Cele\pgp-14
6 of 15
No
Yes
Cele\pgp-3
5 of 15
No
No
Cele\pgp-10
5 of 15
No
Yes
Cele\cft-1
1 of 15
No
No
Cele\haf-1
1 of 15
No
No
Cele\haf-2
1 of 15
No
No
Cele\haf-3
1 of 15
No
No
Cele\haf-4
1 of 15
No
No
Cele\haf-6
1 of 15
No
No
Cele\haf-7
1 of 15
No
No
Cele\haf-8
1 of 15
No
No
Cele\mrp-1
1 of 15
No
No
Cele\mrp-2
1 of 15
No
No
Cele\mrp-3
1 of 15
No
No
Cele\mrp-4
1 of 15
No
No
Cele\mrp-5
1 of 15
No
No
Cele\mrp-6
1 of 15
No
No
Cele\mrp-7
1 of 15
No
No
Cele\mrp-8
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (22)
Atha\ABCB1
7 of 9
Yes
No
Atha\ABCB2
7 of 9
Yes
No
Atha\ABCB3
7 of 9
Yes
No
Atha\ABCB4
7 of 9
Yes
No
Atha\ABCB5
7 of 9
Yes
No
Atha\ABCB7
7 of 9
Yes
No
Atha\ABCB9
7 of 9
Yes
No
Atha\ABCB11
7 of 9
Yes
No
Atha\ABCB12
7 of 9
Yes
No
Atha\ABCB13
7 of 9
Yes
No
Atha\ABCB15
7 of 9
Yes
No
Atha\ABCB17
7 of 9
Yes
No
Atha\ABCB19
7 of 9
Yes
No
Atha\ABCB21
7 of 9
Yes
No
Atha\PGP10
7 of 9
Yes
No
Atha\ABCB14
6 of 9
No
No
Atha\ABCB16
6 of 9
No
Yes
Atha\ABCB18
6 of 9
No
No
Atha\ABCB22
6 of 9
No
No
Atha\ABCB6
3 of 9
No
Yes
Atha\ABCB20
3 of 9
No
Yes
Atha\ABCB29
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (10)
Scer\STE6
7 of 15
Yes
No
1  
Scer\BPT1
1 of 15
No
No
Scer\MDL1
1 of 15
No
No
Scer\MDL2
1 of 15
No
No
Scer\NFT1
1 of 15
No
No
Scer\VMR1
1 of 15
No
No
Scer\YBT1
1 of 15
No
No
Scer\YCF1
1 of 15
No
No
Scer\YKR104W
1 of 15
No
No
Scer\YOR1
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (3)
Spom\pmd1
10 of 12
Yes
No
Spom\mam1
3 of 12
No
Yes
Spom\mdl1
1 of 12
No
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091900Z9 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila simulans
Dsim\GD13132
Drosophila sechellia
Dsec\GM13846
Drosophila erecta
Dere\GG14065
Drosophila yakuba
Dyak\GE20489
Drosophila ananassae
Dana\GF10905
Drosophila pseudoobscura pseudoobscura
Dpse\GA10136
Drosophila persimilis
Dper\GL22523
Drosophila willistoni
Dwil\GK13588
Drosophila virilis
Dvir\GJ12000
Drosophila mojavensis
Dmoj\GI13225
Drosophila grimshawi
Dgri\GH23394
Drosophila grimshawi
Dgri\GH16282
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500JH )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17010834
Musca domestica
House fly
Mdoa\17010833
Musca domestica
House fly
Mdoa\17005466
Glossina morsitans
Tsetse fly
Gmor\GMOY008705
Glossina morsitans
Tsetse fly
Gmor\GMOY007393
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_00005
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_00004
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_13163
Mayetiola destructor
Hessian fly
Mdes\Mdes007343
Mayetiola destructor
Hessian fly
Mdes\Mdes009295
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL010379
Anopheles darlingi
American malaria mosquito
Adar\ADAC007126
Anopheles gambiae
Malaria mosquito
Agam\AGAP005639
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ016887
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0BCM )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA000724
Bombyx mori
Silkmoth
Bmor\BGIBMGA009452
Bombyx mori
Silkmoth
Bmor\BGIBMGA000725
Bombyx mori
Silkmoth
Bmor\BGIBMGA007494
Danaus plexippus
Monarch butterfly
Dple\DPOGS207748-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS207747-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS207818-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS206135-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS207749-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS207746-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS213261-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL008785
Heliconius melpomene
Postman butterfly
Hmel\HMEL004840
Heliconius melpomene
Postman butterfly
Hmel\HMEL011973
Apis florea
Little honeybee
Aflo\2147508467
Apis mellifera
Western honey bee
Amel\GB55378
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20391
Bombus terrestris
Buff-tailed bumblebee
Bter\15214933
Linepithema humile
Argentine ant
Lhum\LH12477
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000b30
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG021290
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_09994
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_09993
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_01739
Tribolium castaneum
Red flour beetle
Tcas\TC003797
Tribolium castaneum
Red flour beetle
Tcas\TC003402
Pediculus humanus
Human body louse
Phum\PHUM177140
Pediculus humanus
Human body louse
Phum\PHUM261630
Pediculus humanus
Human body louse
Phum\PHUM578820
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_04434
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_08525
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0BAA )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR015362
Strigamia maritima
European centipede
Smar\SMAR011846
Strigamia maritima
European centipede
Smar\SMAR009573
Strigamia maritima
European centipede
Smar\SMAR011622
Ixodes scapularis
Black-legged tick
Isca\ISCW017811
Stegodyphus mimosarum
African social velvet spider
Smim\KFM57755.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM59307.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM72296.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM72297.1
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_347265
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_347264
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0HVA )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcb1_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcb10A
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcb1A
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcb8
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcb9A
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcb10B
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcb1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcb9B
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcb1_3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcb4a
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcb1_4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcb1b
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcb4b
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcb9C
Ciona intestinalis
Vase tunicate
Cint\LOC100184731
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000007058
Ciona intestinalis
Vase tunicate
Cint\LOC100182256
Ciona intestinalis
Vase tunicate
Cint\LOC100184484
Ciona intestinalis
Vase tunicate
Cint\LOC100176183
Ciona intestinalis
Vase tunicate
Cint\LOC100180385
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000018443
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000009135
Gallus gallus
Domestic chicken
Ggal\ABCB11
Gallus gallus
Domestic chicken
Ggal\ABCB1
Gallus gallus
Domestic chicken
Ggal\ABCB10
Gallus gallus
Domestic chicken
Ggal\ABCB1
Gallus gallus
Domestic chicken
Ggal\LOC420606
Gallus gallus
Domestic chicken
Ggal\ABCB9
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (21)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG10226
7 of 10
Mdr49
7 of 10
Mdr50
7 of 10
CG1824
2 of 10
CG3156
2 of 10
ABCB7
1 of 10
Cftr
1 of 10
CG4562
1 of 10
CG7627
1 of 10
CG7806
1 of 10
CG9270
1 of 10
CG10505
1 of 10
CG11898
1 of 10
CG31792
1 of 10
CG31793
1 of 10
Hmt-1
1 of 10
l(2)03659
1 of 10
Mrp4
1 of 10
MRP
1 of 10
rdog
1 of 10
Sur
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 3 )
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    Mdr65HMS01449
    exacerbates  neurodegenerative disease
    modeled by Zzzz\CAG127Q.UAS.Tag:HA
    (Yadav and Tapadia, 2013)
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ABCB4; ATP binding cassette subfamily B member 4
    11 of 15
    171060
    ABCB1; ATP binding cassette subfamily B member 1
    8 of 15
    171050
     
    ABCB5; ATP binding cassette subfamily B member 5
    8 of 15
    611785
        ABCB11; ATP binding cassette subfamily B member 11
        8 of 15
        603201
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Interactions Browser
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        eas
        suppressible
        Mdr65
        (Howlett and Tanouye, 2013)
        para
        suppressible
        Mdr65
        (Howlett and Tanouye, 2013)
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        3L
        Recombination map

        3-16

        Cytogenetic map
        65A10-65A10
        Sequence location
        3L:6,240,500..6,245,746 [-]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        65A10-65A10
        Limits computationally determined from genome sequence between P{PZ}l(3)0209402094 and P{lacW}l(3)L4060L4060
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        3-16

        (FlyBase, 2016)

        3-14.5

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (5)
        Genomic Clones (14)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (17)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           

          polyclonal

          (Mayer et al., 2009)
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of

          Source for identity of: Mdr65 CG10181

          (Gabrielian, 1999.11)
          Source for database merge of
          Additional comments
          Other Comments
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 47 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          modMine - A data warehouse for the modENCODE project
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          FlyMine - An integrated database for Drosophila genomics
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Synonyms and Secondary IDs (11)
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (76)