FB2021_01, released Feb 18, 2021

Gene: Dmel\Oct-TyrR

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General Information
Symbol
Dmel\Oct-TyrR
Species
D. melanogaster
Name
Octopamine-Tyramine receptor
Annotation Symbol
CG7485
Feature Type
protein_coding_gene
FlyBase ID
FBgn0004514
Gene Model Status
Current
Stock Availability
15 publicly available
Gene Snapshot
Octopamine-Tyramine receptor (Oct-TyrR) encodes a Tyramine 1 class receptor. When heterologously expressed it shows agonist specific coupling, with tyramine being more potent than octopamine in the inhibition of adenylyl cyclase activity and octopamine being more potent than tyramine in the release of calcium from internal stores. [Date last reviewed: 2019-03-14]
Other Summaries
Also Known As

TyrR, l(3)neo30, Ocr, hono, honoka

Key Links
Genomic Location
Cytogenetic map
79B1-79B2
Sequence location
3L:22,035,003..22,065,279 [+]
Recombination map

3-47

RefSeq locus
NT_037436 REGION:22035003..22065279
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (11 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables G protein-coupled amine receptor activity
inferred from direct assay
(Chatwin et al., 2003, Robb et al., 1994)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables G protein-coupled amine receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN002798402
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity
(Radford et al., 2002, Brody and Cravchik, 2000)
enables G protein-coupled receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN002798190
(assigned by GO_Central )
(Gaudet et al., 2011)
enables octopamine receptor activity
inferred from electronic annotation with InterPro:IPR002002
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
involved_in octopamine or tyramine signaling pathway
inferred from direct assay
(Chatwin et al., 2003, Robb et al., 1994)
inferred from mutant phenotype
(Nagaya et al., 2002)
involved_in positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway
inferred from direct assay
(Robb et al., 1994)
involved_in regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway
inferred from direct assay
(Chatwin et al., 2003, Robb et al., 1994)
involved_in sensory perception of smell
inferred from mutant phenotype
(Kutsukake et al., 2000)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN001205212
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in octopamine or tyramine signaling pathway
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in integral component of plasma membrane
inferred from direct assay
(Chatwin et al., 2003, Robb et al., 1994)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
located_in integral component of membrane
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
located_in integral component of plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN002798190
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in plasma membrane
inferred from sequence or structural similarity with FLYBASE:5-HT7; FB:FBgn0004573
(Saudou et al., 1990)
inferred from sequence or structural similarity with HGNC:5286
(Saudou et al., 1990)
inferred from sequence or structural similarity with FLYBASE:mAChR-A; FB:FBgn0000037
(Arakawa et al., 1990)
inferred from sequence or structural similarity with HGNC:285
(Arakawa et al., 1990)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the G-protein coupled receptor 1 family. (P22270)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
TYRAMINE RECEPTORS -
Tyramine receptors belong to the Class A GPCR family. In mammalian systems, tyramine is a member of the trace amines, but in insects octopamine and tyramine are thought to be the main neurotransmitters. (Adapted from PMID:17088868, FBrf0214056 and FBrf0190865).
OCTOPAMINE RECEPTORS -
Octopamine receptors belong to the Class A GPCR family. In mammalian systems, octopamine is a member of the trace amines, but in insects octopamine and tyramine are thought to be the main neurotransmitters. (Adapted from PMID:17088868, FBrf0214056 and FBrf0190865).
Protein Function (UniProtKB)
Receptor for both octopamine and tyramine, invertebrate neurotransmitters, and neuromodulators. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The rank order of potency for agonists is tyramine > octopamine > dopamine > epinephrine > norepinephrine > serotonin > histamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > cyproheptadine > dihydroergotamine > clonidine > synephrine. Tyramine has a functional role in the olfactory system as a neurotransmitter or a neuromodulator.
(UniProt, P22270)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
Ocr: Octopamine receptor (J.C. Hall)
Independent cDNAs were cloned into expression vectors and transfected into CHO-1 (Arakawa et al., 1990) or Cos-7 (Saudou et al., 1990) cells. Membranes from such cells had high-affinity binding activity to the adrenergic receptor agonist yohimbine; other agonists or antagonists used to compete with this substance showed the octopamine analog, synephrine, to have the highest agonist affinity, higher than octopamine itself; these results along with others which showed greater affinity of the cloned/transduced protein for yohimbine and chlorpromazine than for metoclopramide, suggested that this Drosophila receptor is an "octopamine-1" subtype (Arakawa et al., 1990). Membranes preparations from the Cos-cell transfectants also had high affinity for yohimbine, and tyramine (e.g. greater than octopamine), suggesting to Saudou et al. (1990) that this Drosophila gene encodes a tyramine receptor. Stably transfected mouse cell lines were also made (Saudou et al., 1990); additions of monoamines to them (e.g. tyramine, octopamine) do not by themselves lead to changes in cAMP levels, but forskolin-elicited cAMP increases were reduced by added tyramine (which was more effective than octopamine). Rough anatomical localization revealed a head-enriched mRNA (3.6 kb: Arakawa et al., 1990; 3.5 kb: Saudou et al., 1990).
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Oct-TyrR for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Oct-TyrR-RA
FBtr0078479
NM_079695
3682
601
Oct-TyrR-RB
FBtr0301930
NM_001170023
3675
601
Additional Transcript Data and Comments
Reported size (kB)

3.6 (northern blot)

(Arakawa et al., 1990)

4.3 (northern blot)

(Saudou et al., 1990)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Oct-TyrR-PA
FBpp0078132
64.7
601
8.09
NP_524419
AAF51802
Oct-TyrR-PB
FBpp0291142
64.7
601
8.09
NP_001163494
ACZ94765
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

601 aa isoforms: Oct-TyrR-PA, Oct-TyrR-PB
Additional Polypeptide Data and Comments
Reported size (kDa)

601 (aa); 65 (kD predicted)

(Arakawa et al., 1990)

601 (aa)

(Saudou et al., 1990)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Oct-TyrR using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Saudou et al., 1990)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult Malpighian tubule
(Blumenthal, 2003)
adult brain
(El-Kholy et al., 2015)
male reproductive system
(El-Kholy et al., 2015)
third instar larval stage
embryonic/larval brain
(El-Kholy et al., 2015)
embryonic/larval trachea
(El-Kholy et al., 2015)
embryonic/larval Malpighian tubule
(El-Kholy et al., 2015)
Additional Descriptive Data

TyrR transcripts are relatively rare and are enriched in adult heads relative to adult bodies.

(Arakawa et al., 1990)

TyrR transcripts are detected in adult heads but not bodies.

(Saudou et al., 1990)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in integral component of plasma membrane
inferred from direct assay
(Chatwin et al., 2003, Robb et al., 1994)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Oct-TyrR in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 20 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Oct-TyrR
Transgenic constructs containing regulatory region of Oct-TyrR
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation
Gene not disrupted in
Df(3L)Pc-MK
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
Inferred from location
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (8)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ADRA2B
2 of 15
Yes
No
Hsap\ADRA2C
2 of 15
Yes
No
Hsap\HTR1A
2 of 15
Yes
No
Hsap\ADRA2A
1 of 15
No
No
Hsap\DRD2
1 of 15
No
No
6  
Hsap\DRD3
1 of 15
No
No
Hsap\HTR1D
1 of 15
No
No
1  
Hsap\MAS1
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Adra2a
2 of 15
Yes
No
Mmus\Adra2c
2 of 15
Yes
No
Mmus\Htr1a
2 of 15
Yes
No
Mmus\Adra2b
1 of 15
No
No
Mmus\Drd2
1 of 15
No
No
Mmus\Drd3
1 of 15
No
No
Mmus\Htr1d
1 of 15
No
No
Rattus norvegicus (Norway rat) (7)
Rnor\Adra2a
2 of 13
Yes
No
Rnor\Adra2b
2 of 13
Yes
No
Rnor\Adra2c
2 of 13
Yes
No
Rnor\Htr1a
2 of 13
Yes
No
Rnor\Drd2
1 of 13
No
No
Rnor\Drd3
1 of 13
No
No
Rnor\Htr1d
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (7)
Xtro\adra2b
2 of 12
Yes
No
Xtro\adra2c
2 of 12
Yes
No
Xtro\adra2a
1 of 12
No
Yes
Xtro\drd2
1 of 12
No
No
Xtro\htr1a
1 of 12
No
No
Xtro\htr1d
1 of 12
No
Yes
Xtro\LOC100493940
1 of 12
No
Yes
Danio rerio (Zebrafish) (15)
Drer\adra2a
3 of 15
Yes
No
Drer\adra2b
3 of 15
Yes
No
Drer\adra2c
3 of 15
Yes
No
Drer\adra2da
3 of 15
Yes
No
Drer\adra2db
3 of 15
Yes
No
Drer\LOC100330650
3 of 15
Yes
No
Drer\htr1aa
2 of 15
No
No
Drer\drd2a
1 of 15
No
No
Drer\drd2b
1 of 15
No
No
Drer\drd2l
1 of 15
No
No
Drer\drd3
1 of 15
No
No
Drer\drd4-rs
1 of 15
No
No
Drer\htr1ab
1 of 15
No
No
Drer\htr1d
1 of 15
No
No
Drer\htr1fb
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (9)
Cele\ser-2
9 of 15
Yes
Yes
Cele\tyra-3
5 of 15
No
Yes
Cele\tyra-2
4 of 15
No
Yes
Cele\dop-3
1 of 15
No
No
Cele\dop-4
1 of 15
No
No
Cele\octr-1
1 of 15
No
No
Cele\ser-1
1 of 15
No
No
Cele\ser-4
1 of 15
No
No
Cele\ser-6
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091906H7 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00007923
Drosophila simulans
Dsim\GD15016
Drosophila sechellia
Dsec\GM22427
Drosophila erecta
Dere\GG16242
Drosophila yakuba
Dyak\GE23022
Drosophila ananassae
Dana\GF10941
Drosophila pseudoobscura pseudoobscura
Dpse\GA20386
Drosophila persimilis
Dper\GL25423
Drosophila willistoni
Dwil\GK10695
Drosophila virilis
Dvir\GJ13904
Drosophila mojavensis
Dmoj\GI13571
Drosophila grimshawi
Dgri\GH14438
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091503B0 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17019162
Glossina morsitans
Tsetse fly
Gmor\GMOY002382
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_10982
Mayetiola destructor
Hessian fly
Mdes\Mdes015213
Aedes aegypti
Yellow fever mosquito
Aaeg\GPRTYR
Anopheles darlingi
American malaria mosquito
Adar\ADAC009398
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ013218
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W08LZ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA011067
Danaus plexippus
Monarch butterfly
Dple\DPOGS205267-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL016209
Apis florea
Little honeybee
Aflo\2257821524
Apis mellifera
Western honey bee
Amel\tyr1
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP13424
Bombus terrestris
Buff-tailed bumblebee
Bter\15203929
Linepithema humile
Argentine ant
Lhum\LH20865
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00157c
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG001406
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08538
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10963
Tribolium castaneum
Red flour beetle
Tcas\TC004545
Pediculus humanus
Human body louse
Phum\PHUM238080
Rhodnius prolixus
Kissing bug
Rpro\RPRC008712
Cimex lectularius
Bed bug
Clec\CLEC002446
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007379
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_15640
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_15639
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X08HK )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR006454
Ixodes scapularis
Black-legged tick
Isca\ISCW013655
Ixodes scapularis
Black-legged tick
Isca\ISCW005195
Stegodyphus mimosarum
African social velvet spider
Smim\KFM59046.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM61746.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur25g01530
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G06VI )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Htr1b_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Htr1aL_5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-5ht1a
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hrh1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-MachrM4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-5ht1F
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Drd1_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Adra1a
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-MachrM5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Drd1_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-5ht7
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hrh2_3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Htr1b
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_009149gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-5ht2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-MachrM3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Drd2L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Htr1a
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Drd2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Drd1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Drd1_3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hrh2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Htr1aL_4
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000018919
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000019975
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000020513
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000004433
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000013284
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000004781
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000003264
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000024198
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000008896
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000002943
Ciona intestinalis
Vase tunicate
Cint\LOC100176265
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000014975
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000015953
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000026029
Gallus gallus
Domestic chicken
Ggal\HTR1A
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000023521
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000008949
Gallus gallus
Domestic chicken
Ggal\HTR1D
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000009640
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000024171
Gallus gallus
Domestic chicken
Ggal\HTR2A
Gallus gallus
Domestic chicken
Ggal\HTR1F
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000000469
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000003050
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000007794
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000019018
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000006362
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000004066
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000015974
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000006540
Gallus gallus
Domestic chicken
Ggal\HTR2C
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000003270
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000015117
Gallus gallus
Domestic chicken
Ggal\HTR1E
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000001416
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000010778
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000001383
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000005085
Gallus gallus
Domestic chicken
Ggal\HTR1B
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000004930
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000013994
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000013995
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000012040
Gallus gallus
Domestic chicken
Ggal\Gga.320
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000008365
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000012894
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000026998
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000015608
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000016013
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (20)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Dop2R
3 of 10
5-HT7
2 of 10
Dop1R2
2 of 10
DopEcR
2 of 10
Octα2R
2 of 10
Octβ1R
2 of 10
Octβ3R
2 of 10
TyrRII
2 of 10
TyrR
2 of 10
5-HT1A
1 of 10
5-HT1B
1 of 10
5-HT2B
1 of 10
CG12290
1 of 10
CG13579
1 of 10
Dop1R1
1 of 10
mAChR-A
1 of 10
mAChR-B
1 of 10
mAChR-C
1 of 10
Oamb
1 of 10
Octβ2R
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Interactions Browser
    Summary of Genetic Interactions
    esyN Network Diagram
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map

    3-47

    Cytogenetic map
    79B1-79B2
    Sequence location
    3L:22,035,003..22,065,279 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    79B1-79B2
    Limits computationally determined from genome sequence between P{lacW}l(3)j1B10j1B10 and P{lacW}l(3)j2C4j2C4
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    79C-79D
    (determined by in situ hybridisation)
    (Kutsukake et al., 2000)
    79D1-79D4
    (determined by in situ hybridisation)
    (Spradling et al., 1999)
    79D1-79D4
    (BDGP Project Members, 1994-1999)
    99A10-99B1
    (determined by in situ hybridisation)
    (Arakawa et al., 1990)
    79D-79D
    (determined by in situ hybridisation)
    (Cooley et al., 1988)
    Stated as 99A10--B1, subsequently revised (see FBrf0126774).
    (Arakawa et al., 1990)
    Experimentally Determined Recombination Data
    Location

    3-47

    (FlyBase, 2016)

    3-44.0

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (15)
    Genomic Clones (32)
    cDNA Clones (16)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of

        Source for identity of: hono l(3)neo30

        (Kutsukake et al., 2000)

        Source for identity of: Oct-TyrR TyrR

        (FlyBase, 2009-)
        Source for database merge of

        Source for merge of: Ocr CG7485

        (Misra, 2000.4.14)

        Source for merge of: Ocr l(3)neo30

        (Kutsukake et al., 2000)
        Additional comments

        FlyBase Curator comment: The product of the CG7485 (FBgn0004514) gene has been characterized and referred to as both an "octopamine receptor" (e.g. FBrf0052683) and a "tyramine receptor" (e.g. FBrf0051655). Several other studies have explicitly referred to it as a mixed-type "octopamine/tyramine receptor" (e.g. FBrf0068659, FBrf0099466, FBrf0155846, FBrf0189828). The FlyBase symbol/name has been changed from 'TyrR/Tyramine receptor' to 'Oct-TyrR/Octopamine-Tyramine receptor' to reflect this.

        (FlyBase, 2009-)
        Other Comments

        Tyramine, rather than octopamine, is likely to be the true ligand of the TyrR product. Tyramine seems to function as a neuromodulator.

        (Nagaya et al., 2002)

        Mutants show defective olfactory behaviour.

        (Kutsukake et al., 2000)

        The octopamine/tyramine receptor, when permanently expressed in a heterologous cell line both inhibits adenylate cyclase activity and leads to elevation of intracellular calcium levels by separate G-protein coupled pathways.

        (Robb et al., 1994)

        Identification: On the basis of sequence similarity to the human Β2-adrenergicreceptor. Sequence and pharmacological considerations indicate that the TyrR product may be an evolutionary precursor to mammalian adrenergic receptors.

        (Arakawa et al., 1990)
        Origin and Etymology
        Discoverer
        Etymology

        'honoka' means 'faint smell' in Japanese.

        (Kutsukake et al., 2000)
        Identification
        External Crossreferences and Linkouts ( 38 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        Linkouts
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        Synonyms and Secondary IDs (34)
        Reported As
        Symbol Synonym
        CG7485
        (Bayliss et al., 2013, Stowers, 2011, Perkins et al., 2009, Hauser et al., 2006, Cazzamali et al., 2005, Evans and Maqueira, 2005)
        DmTAR1
        (Qi et al., 2017, Bayliss et al., 2013)
        DmTyrR
        (Roeder et al., 2003)
        Dmoct/tyr
        (Blenau and Baumann, 2001)
        DrmOTR
        (Cazzamali et al., 2005)
        OA-R
        (Buchner, 1991)
        OAR_DROME
        (Maqueira et al., 2005)
        OTR
        (Cazzamali et al., 2005)
        OcR
        (Chatwin et al., 2003)
        Ocr
        (Brody and Cravchik, 2000, Coulier et al., 2000, Endo et al., 2000)
        Oct-TyrR
        (Deng, 2020.1.10, Feuillette et al., 2020, Deng et al., 2019, Highfill et al., 2019, Meltzer et al., 2019, Rao and Deng, 2019.10.23, Levis, 2018.8.30, Bazargani and Attwell, 2017, Damrau et al., 2017, Clandinin and Owens, 2016-, Crocker et al., 2016, Ma et al., 2016, Deady and Sun, 2015, Soshnev et al., 2013)
        Oct/Tyr
        (Bazargani and Attwell, 2017)
        OctoR1
        (Hall et al., 1991)
        OctyR99AB
        (Feng et al., 1996)
        TAR1
        (Bayliss et al., 2013)
        TYR
        (Han et al., 1998)
        TyR
        Tyr
        (Zumstein et al., 2004)
        Tyr-OctR
        (Youn et al., 2018)
        Tyr-dro
        (Saudou et al., 1990)
        TyrR
        (El-Kholy et al., 2015, Stowers, 2011, Pospisilik et al., 2010, Anaka et al., 2008, Enan, 2005)
        hono
        (Schützler et al., 2019, Hirsh and Burnette, 2001.5.9, Endo et al., 2000)
        l(3)neo30
        (Kutsukake et al., 2000, Spradling et al., 1999, BDGP Project Members, 1994-1999, Cooley et al., 1988)
        tar1
        (Li et al., 2017)
        Name Synonyms
        Oct/Tyr receptor
        (Bayliss et al., 2013)
        Octopamine receptor
        Octopamine receptor 1
        (Hall et al., 1991)
        Octopamine-Tyramine receptor
        Octopamine/Tyramine receptor
        (Bayliss et al., 2013)
        Tyramine receptor
        (Anaka et al., 2008, Saudou et al., 1990)
        Tyramine-receptor
        honoka
        (Schützler et al., 2019, Kutsukake et al., 2000)
        octopamine/tyramine receptor
        (Ma et al., 2016, Faisal et al., 2014, Cazzamali et al., 2005)
        tyramine receptor
        (Stowers, 2011, Zumstein et al., 2004, Blumenthal, 2003)
        Secondary FlyBase IDs
        • FBgn0002983
        • FBgn0004109
        • FBgn0011463
        • FBgn0037148
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (106)