5HT7, 5-HT7, 5HT-dro1, 5-HT7Dro, 5-HT7Dro
seven-pass transmembrane protein implicated in regulation of courtship behavior, mating, olfactory learning and memory
Please see the JBrowse view of Dmel\5-HT7 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.47
5.5 (northern blot)
564 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\5-HT7 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
5-HT7 transcripts are detected throughout development with a peak in 16-24hr embryos. They are found in adult heads but not bodies. In embryos, expression starts in stage 16 and is restricted to the CNS. 5-HT7 transcripts are expressed in lateral rows of cells on each side of the midline and at a low level in midline cells.
5-HT7 transcripts are detected in RNA from adult heads but not bodies.
JBrowse - Visual display of RNA-Seq signals
View Dmel\5-HT7 in JBrowse
3-102
3-98.8
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
5-HT7 receptor stimulates adenylate cyclase. Expression starts in late embryos and is restricted to distinct cell populations in the CNS.
