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Gene Dmel\5-HT7

General Information
Symbol	Dmel\5-HT7	Species	D. melanogaster
Name	Serotonin receptor 7	Annotation symbol	CG12073
Feature type	protein_coding_gene	FlyBase ID	FBgn0004573
Gene Model Status	Current	Stock availability	9 publicly available
Also Known As	5-HT7, 5HT-dro1, 5-HT7Dro, 5-HT7Dro
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	100B1-100B1	Sequence location	3R:26,793,958..26,842,597 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Serotonin receptor 7 is referred to in FlyBase by the symbol Dmel\5-HT7 (CG12073, FBgn0004573). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: G-protein coupled amine receptor activity; serotonin receptor activity. There is experimental evidence that it is involved in the biological process: male courtship behavior, proboscis-mediated licking; female mating behavior; male mating behavior; courtship behavior; male courtship behavior, orientation prior to leg tapping and wing vibration; male courtship behavior, veined wing vibration. 11 alleles are reported. The phenotype of these alleles is annotated with: Malpighian tubule. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Dopamine receptor family; G protein-coupled receptor, rhodopsin-like; GPCR, rhodopsin-like, 7TM. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult salivary gland. Comments on Affy2 ProbeSet: ProbeSet 1632131_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of 5-HT7. Gene sequence location is 3R:26793958..26842597.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 100B1-100B1   Limits computationally determined from genome sequence between P{lacW}l(3)s2500s2500 and P{PZ}Aph-407028&P{PZ}dcorK215
Experimentally Determined Cytological Location
Cytogenetic map Notes References 100A-100A   (determined by in situ hybridisation)   (Boschert et al., 1991.12.17) 100A-100A   (determined by in situ hybridisation)   (Boschert et al., 1991) 100A-100A   (determined by in situ hybridisation)   (Saudou et al., 1992) 99F-100A   (determined by in situ hybridisation)   (Witz et al., 1990)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\5-HT7 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) 5-HT7-RA FBtr0085746  NM_079860   3506   564 5-HT7-RB FBtr0334508  NM_001276202   4486   564
Additional Transcript Data & Comments
Reported size (kB)	5.5 (northern blot) (Saudou et al., 1992, Witz et al., 1990)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein 5-HT7-PA   FBpp0085108   60.9   564   8.06     NP_524599   AAF57104 5-HT7-PB   FBpp0306575   60.9   564   8.06     NP_001263131   AGB96510
Additional Polypeptide Data & Comments
Reported size (kDa)	564 (aa) (Witz et al., 1990)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • G protein-coupled receptor, rhodopsin-like (IPR000276) Dopamine receptor family (IPR000929) GPCR, rhodopsin-like, 7TM (IPR017452) 5-Hydroxytryptamine receptor family (IPR002231)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201540   AE014297 AAF57104   AE014297 AGB96510   AI542400   AW941548   AY118491 AAM49860   BG639923   BI367246   BI371960   BI374506   CO177612   CO310725   CO334015   CO334035   CO344626   CZ487840   CZ487841   DD177576   EC057310   EC072605   EC081016   EC090824   EC215876   EC239913   EC248023   EC257489   GH759431   GH793410   GH809729   GH829202   GH872909   GH879805   GH883083   GH920736   M55533 AAA28305
UniProtKB/Swiss-Prot	P20905
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 13 -- 16   embryonic/larval midgut interstitial cell   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 16 -- 17   ventral midline   (Saudou et al., 1992) adult stage   adult head   (Witz et al., 1990)
Additional Descriptive Data
	5-HT7 transcripts are detected in RNA from adult heads but not bodies. (Witz et al., 1990) 5-HT7 transcripts are detected throughout development with a peak in 16-24hr embryos. They are found in adult heads but not bodies. In embryos, expression starts in stage 16 and is restricted to the CNS. 5-HT7 transcripts are expressed in lateral rows of cells on each side of the midline and at a low level in midline cells. (Saudou et al., 1992)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult salivary gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    22.9 Larval Midgut    26.4 Larval Hindgut    4.6 Larval Malpighian Tubules    85.6 Larval Fat Body    1.9 Larval Salivary Gland    1.5 Larval Trachea    1.625 Larval Carcass    1.775 Adult Head    13.3 Adult Eye    5.55 Adult Brain    70.2 Adult Thoracic-Abdominal Ganglion    74 Adult Crop    17.8 Adult Midgut    5.8 Adult Hindgut    4.1 Adult Malpighian Tubules    3.4 Adult Fat Body    4.8 Adult Salivary Gland    117.5 Adult Heart    5.775 Adult VirginFemale Spermatheca    3.6 Adult InseminatedFemale Spermatheca    4.2 Adult Ovary    1.6 Adult Testis    1.3 Adult Male Accessory Gland    14 Adult Carcass    4.6 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    22.9 Larval Midgut    26.4 Larval Hindgut    4.6 Larval Malpighian Tubules    85.6 Larval Fat Body    1.9 Larval Salivary Gland    1.5 Larval Trachea    1.625 Larval Carcass    1.775 Adult Head    13.3 Adult Eye    5.55 Adult Brain    70.2 Adult Thoracic-Abdominal Ganglion    74 Adult Crop    17.8 Adult Midgut    5.8 Adult Hindgut    4.1 Adult Malpighian Tubules    3.4 Adult Fat Body    4.8 Adult Salivary Gland    117.5 Adult Heart    5.775 Adult VirginFemale Spermatheca    3.6 Adult InseminatedFemale Spermatheca    4.2 Adult Ovary    1.6 Adult Testis    1.3 Adult Male Accessory Gland    14 Adult Carcass    4.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    22.9 Larval Midgut    26.4 Larval Hindgut    4.6 Larval Malpighian Tubules    85.6 Larval Fat Body    1.9 Larval Salivary Gland    1.5 Larval Trachea    1.625 Larval Carcass    1.775 Adult Head    13.3 Adult Eye    5.55 Adult Brain    70.2 Adult Thoracic-Abdominal Ganglion    74 Adult Crop    17.8 Adult Midgut    5.8 Adult Hindgut    4.1 Adult Malpighian Tubules    3.4 Adult Fat Body    4.8 Adult Salivary Gland    117.5 Adult Heart    5.775 Adult VirginFemale Spermatheca    3.6 Adult InseminatedFemale Spermatheca    4.2 Adult Ovary    1.6 Adult Testis    1.3 Adult Male Accessory Gland    14 Adult Carcass    4.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    22.9 Larval Midgut    26.4 Larval Hindgut    4.6 Larval Malpighian Tubules    85.6 Larval Fat Body    1.9 Larval Salivary Gland    1.5 Larval Trachea    1.625 Larval Carcass    1.775 Adult Head    13.3 Adult Eye    5.55 Adult Brain    70.2 Adult Thoracic-Abdominal Ganglion    74 Adult Crop    17.8 Adult Midgut    5.8 Adult Hindgut    4.1 Adult Malpighian Tubules    3.4 Adult Fat Body    4.8 Adult Salivary Gland    117.5 Adult Heart    5.775 Adult VirginFemale Spermatheca    3.6 Adult InseminatedFemale Spermatheca    4.2 Adult Ovary    1.6 Adult Testis    1.3 Adult Male Accessory Gland    14 Adult Carcass    4.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    22.9 Larval Midgut    26.4 Larval Hindgut    4.6 Larval Malpighian Tubules    85.6 Larval Fat Body    1.9 Larval Salivary Gland    1.5 Larval Trachea    1.625 Larval Carcass    1.775 Adult Head    13.3 Adult Eye    5.55 Adult Brain    70.2 Adult Thoracic-Abdominal Ganglion    74 Adult Crop    17.8 Adult Midgut    5.8 Adult Hindgut    4.1 Adult Malpighian Tubules    3.4 Adult Fat Body    4.8 Adult Salivary Gland    117.5 Adult Heart    5.775 Adult VirginFemale Spermatheca    3.6 Adult InseminatedFemale Spermatheca    4.2 Adult Ovary    1.6 Adult Testis    1.3 Adult Male Accessory Gland    14 Adult Carcass    4.6 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    22.9 Larval Midgut    26.4 Larval Hindgut    4.6 Larval Malpighian Tubules    85.6 Larval Fat Body    1.9 Larval Salivary Gland    1.5 Larval Trachea    1.625 Larval Carcass    1.775 Adult Head    13.3 Adult Eye    5.55 Adult Brain    70.2 Adult Thoracic-Abdominal Ganglion    74 Adult Crop    17.8 Adult Midgut    5.8 Adult Hindgut    4.1 Adult Malpighian Tubules    3.4 Adult Fat Body    4.8 Adult Salivary Gland    117.5 Adult Heart    5.775 Adult VirginFemale Spermatheca    3.6 Adult InseminatedFemale Spermatheca    4.2 Adult Ovary    1.6 Adult Testis    1.3 Adult Male Accessory Gland    14 Adult Carcass    4.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    22.9 Larval Midgut    26.4 Larval Hindgut    4.6 Larval Malpighian Tubules    85.6 Larval Fat Body    1.9 Larval Salivary Gland    1.5 Larval Trachea    1.625 Larval Carcass    1.775 Adult Head    13.3 Adult Eye    5.55 Adult Brain    70.2 Adult Thoracic-Abdominal Ganglion    74 Adult Crop    17.8 Adult Midgut    5.8 Adult Hindgut    4.1 Adult Malpighian Tubules    3.4 Adult Fat Body    4.8 Adult Salivary Gland    117.5 Adult Heart    5.775 Adult VirginFemale Spermatheca    3.6 Adult InseminatedFemale Spermatheca    4.2 Adult Ovary    1.6 Adult Testis    1.3 Adult Male Accessory Gland    14 Adult Carcass    4.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    22.9 Larval Midgut    26.4 Larval Hindgut    4.6 Larval Malpighian Tubules    85.6 Larval Fat Body    1.9 Larval Salivary Gland    1.5 Larval Trachea    1.625 Larval Carcass    1.775 Adult Head    13.3 Adult Eye    5.55 Adult Brain    70.2 Adult Thoracic-Abdominal Ganglion    74 Adult Crop    17.8 Adult Midgut    5.8 Adult Hindgut    4.1 Adult Malpighian Tubules    3.4 Adult Fat Body    4.8 Adult Salivary Gland    117.5 Adult Heart    5.775 Adult VirginFemale Spermatheca    3.6 Adult InseminatedFemale Spermatheca    4.2 Adult Ovary    1.6 Adult Testis    1.3 Adult Male Accessory Gland    14 Adult Carcass    4.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    13.3   NA  Eye    5.55   NA  Brain    70.2   22.9  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    74   NA  Crop    17.8   26.4  Midgut    5.8   4.6  Hindgut    4.1   85.6  Malpighian Tubules    3.4   1.9  Fat Body    4.8   1.5  Salivary Gland    117.5   NA  Heart    5.775   1.625  Trachea    NA   NA  VirginFemale Spermatheca    3.6   NA  InseminatedFemale Spermatheca    4.2   NA  Ovary    1.6   NA  Testis    1.3   NA  Male Accessory Gland    no informative data   1.775  Carcass    4.6 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    5 central nervous system, pupae P8    17 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    7 head, mated 4-day male    8 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    6 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    5 central nervous system, pupae P8    17 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    7 head, mated 4-day male    8 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    6 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    5 central nervous system, pupae P8    17 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    7 head, mated 4-day male    8 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    6 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    5 central nervous system, pupae P8    17 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    7 head, mated 4-day male    8 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    6 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    5 central nervous system, pupae P8    17 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    7 head, mated 4-day male    8 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    6 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    5 central nervous system, pupae P8    17 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    7 head, mated 4-day male    8 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    6 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    5 central nervous system, pupae P8    17 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    7 head, mated 4-day male    8 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    6 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    5 central nervous system, pupae P8    17 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    7 head, mated 4-day male    8 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    6 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    3 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    4 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    2 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    3 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    4 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    2 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    3 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    4 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    2 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    3 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    4 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    2 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    3 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    4 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    2 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    3 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    4 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    2 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    3 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    4 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    2 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    3 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    4 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    2 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_14 mE1_20_mRNA_expression_cluster_13
External Data & Images
Linkouts	BDGP expression data • LD04507 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004573 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12073-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for 5-HT7 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable 5-HT7f05214 Sterility Allele fertile 5-HT7f05214 Other Phenotypes Allele courtship behavior defective, with Scer\GAL45-HT7.ERGP 5-HT7dsRNA.Sym.Scer\UAS mating behavior defective, with Scer\GAL45-HT7.ERGP 5-HT7dsRNA.Sym.Scer\UAS short lived, with Scer\GAL4Ilp2.PW 5-HT7Scer\UAS.cKa starvation stress response defective, with Scer\GAL4Ilp2.PW 5-HT7Scer\UAS.cKa Phenotype manifest in Allele Malpighian tubule, with Scer\GAL4c42 5-HT7Scer\UAS.cKa Malpighian tubule, with Scer\GAL4tsh-c724 5-HT7Scer\UAS.cKa
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of 5-HT7 Class Mutagen Stocks Known lesion 5-HT7f05214 piggyBac transposase 2 -- 5-HT7MB01344 1 -- 5-HT7MB04445 1 -- 5-HT7MI00215 1 -- 5-HT7MI01380 1 --
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of 5-HT7 Class Mutagen Stocks Known lesion 5-HT7HMS00471 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes 5-HT7JF02576 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes 5-HT7KK109754 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes 5-HT7dsRNA.Sym.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes 5-HT7GD704 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes 5-HT7Scer\UAS.cKa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6260 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD704} NA P{KK109754} NA P{TRiP.HMS00471} NA P{TRiP.JF02576} NA P{UAS-5-HT7.dsRNA} NA P{UAS-5-HT7.K} NA GAL4 construct P{5-HT7-GAL4.B} No
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}5-HT7MI00215 NA Mi{MIC}5-HT7MI01380 NA PBac{WH}5-HT7f05214 NA insertion of enhancer trap binary system Mi{ET1}5-HT7MB01344 No Mi{ET1}5-HT7MB04445 No
Gene Ontology: Function, Process & Cellular Component ( 14 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
courtship behavior inferred from mutant phenotype (Becnel et al., 2011) female mating behavior inferred from mutant phenotype (Becnel et al., 2011) male courtship behavior, orientation prior to leg tapping and wing vibration inferred from mutant phenotype (Becnel et al., 2011) male courtship behavior, proboscis-mediated licking inferred from mutant phenotype (Becnel et al., 2011) male courtship behavior, veined wing vibration inferred from mutant phenotype (Becnel et al., 2011) male mating behavior inferred from mutant phenotype (Becnel et al., 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
dopamine neurotransmitter receptor activity inferred from electronic annotation with InterPro:IPR000929 (FlyBase Curators et al., 2004-) G-protein coupled amine receptor activity inferred from sequence or structural similarity (Radford et al., 2002) serotonin receptor activity inferred from sequence or structural similarity (Brody and Cravchik, 2000) inferred from sequence or structural similarity with UniProtKB:Q64264 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1991.2.1) traceable author statement (Tierney, 2001)
Biological Process
CV term Evidence References
adenylate cyclase-activating serotonin receptor signaling pathway non-traceable author statement (Swiss-Prot Project Members, 1991.2.1) traceable author statement (Tierney, 2001) serotonin receptor signaling pathway inferred from sequence or structural similarity (Brody and Cravchik, 2000) inferred from sequence or structural similarity with UniProtKB:Q64264 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
integral to membrane inferred from sequence or structural similarity (Brody and Cravchik, 2000) integral to plasma membrane inferred from electronic annotation with InterPro:IPR000929, InterPro:IPR002231 (FlyBase Curators et al., 2004-) non-traceable author statement (Swiss-Prot Project Members, 1991.2.1) plasma membrane inferred from sequence or structural similarity with mouse Htr2c (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
5-HT7 - ATPsyn-γ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Atpα anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Bap55 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - CG10077 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - CG10830 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - CG11266 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - CG12264 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - CG15098 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - CG2064 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - CG2065 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - CG3164 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - CG31729 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - CG32138 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - CG4169 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - CG6543 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - CG7033 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - CG7668 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - CG8258 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Cctγ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Cdc42 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Chc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Chd64 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - CtBP anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Eno anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Gfat2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Gp210 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Jupiter anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Kap-α3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Karyβ3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Kr-h2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - MRP anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Map205 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Mec2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Nedd4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Past1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Pgam5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Prp8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Psa anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Pvr anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - R anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - RanGAP anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Ranbp9 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Ras64B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Rop anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - RpS10b anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - RpS19a anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Rpn1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Rpt1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Rpt2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Rpt4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Rpt5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Rpt6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Scamp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Sec23 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Sec61α anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Shc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Srp54 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Srp72 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Su(dx) anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Syx7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Tcp-1ζ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Tcp-1η anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Vap-33-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Vha55 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - Vha68-2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - alt anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - bor anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - cher anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - eIF3-S8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - eIF6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - emb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - fax anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - gho anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - kcc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - kst anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - l(1)G0156 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - nop5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - poe anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - polo anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - porin anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - vnc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - yata anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - α-Spec anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - βCop anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) 5-HT7 - γCop anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions 5-HT7 allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0004573 DroID - A comprehensive database of gene and protein interactions. • FBgn0004573
Orthologs
OrthoDB Orthologs (43) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6G7CJ4 Dipteran inclusive ortholog search EOG6JT0F3 Insect inclusive ortholog search EOG69W19T Arthropod inclusive ortholog search EOG69W0WS Metazoa inclusive ortholog search EOG6VF2RM
Orthologs in Drosophila Species (EOG6G7CJ4)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\5-HT7     Drosophila simulans   Dsim\GD16708 Y   Drosophila sechellia   Dsec\GM12116 Y   Drosophila erecta   Dere\GG11898 Y   Drosophila yakuba   Dyak\GE23347 Y   Drosophila ananassae   Dana\GF23300 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA11376 Y   Drosophila persimilis   Dper\GL13974 Y   Drosophila willistoni   Dwil\GK13099 Y   Drosophila virilis   Dvir\GJ10661 Y   Drosophila mojavensis   Dmoj\GI10445 Y   Drosophila grimshawi   Dgri\GH14351 Y
Orthologs in non-Drosophila Dipterans (EOG6JT0F3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL009573   Aedes aegypti Yellow fever mosquito  Aaeg\GPR5HT5B   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL016993   Anopheles gambiae Malaria mosquito  Agam\GPRNNA20   Anopheles gambiae Malaria mosquito  Agam\GPR5HT7   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ015747   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ016039
Orthologs in non-Dipteran Insects (EOG69W19T)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB45788   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG000347   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG036914   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH11430   Atta cephalotes Leafcutter ant  Acep\ACEP21770   Atta cephalotes Leafcutter ant  Acep\ACEP21771   Camponotus floridanus Florida carpenter ant  Cflo\CFLO14069   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16345   Linepithema humile Argentine ant  Lhum\LH13147   Pogonomyrmex barbatus Red harvester ant  Pbar\PB27304   Solenopsis invicta Red fire ant  Sinv\SINV23899   Solenopsis invicta Red fire ant  Sinv\SINV23901   Acyrthosiphon pisum Pea aphid  Apim\ACYPI51052   Bombyx mori Silkmoth  Bmor\BGIBMGA002287   Pediculus humanus Human body louse  Phum\PHUM204430   Tribolium castaneum Red flour beetle  Tcas\TC011667
Orthologs in non-Insect Arthropods (EOG69W0WS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_19892   Daphnia pulex Water flea  Dpux\BICD2   Daphnia pulex Water flea  Dpux\bstXIR   Ixodes scapularis Deer tick  Isca\ISCW019072   Ixodes scapularis Deer tick  Isca\ISCW019070
Orthologs in non-Arthropod Metazoa (EOG6VF2RM)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\ser-7   Caenorhabditis elegans Nematode  Cele\tyra-3   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_005097gn
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD16708 Drosophila sechellia Dsec\GM12116 Drosophila erecta Dere\GG11898 Drosophila yakuba Dyak\GE23347 Drosophila ananassae Dana\GF23300 Drosophila pseudoobscura pseudoobscura Dpse\GA11376 Drosophila persimilis Dper\GL13974 Drosophila willistoni Dwil\GK13099 Drosophila virilis Dvir\GJ10661 Drosophila mojavensis Dmoj\GI10445 Drosophila grimshawi Dgri\GH14351
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	18848 w1118; PBac{WH}5-HT7f05214 27273 y1 v1; P{TRiP.JF02576}attP2 41466 y1 w*; Mi{MIC}5-HT7MI01380 23066 y1 w67c23; Mi{ET1}5-HT7MB01344 32471 y1 sc* v1; P{TRiP.HMS00471}attP2 24705 w1118; Mi{ET1}5-HT7MB04445 CG31008MB04445 30667 y1 w*; Mi{MIC}5-HT7MI00215/TM6B, Tb1
Harvard	- PBac{WH}5-HT7f05214
VDRC	v104804 P{KK109754}VIE-260B
Genomic Clones ( 2 )
	BACR03C06 BACR06P08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 27 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD04507
Other clones	DPiM_LD04507
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE52963 RE55463 RE62116
Other clones	17382 99575 175577 214283.26 282853 283209 CK01.14D.A2 CK01.66B.E9 EK053917 EK222349 EK308622 EK308715 EP19628 RP003085578 RP003296045 RP003303925 RP003329011 RP003349981 RP003404876 RP003455123 RP003527084 SD08703
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004573 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43669
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	5-HT7 receptor stimulates adenylate cyclase. Expression starts in late embryos and is restricted to distinct cell populations in the CNS. (Saudou et al., 1992)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079860 NM_001276202 RefSeq (Proteins) • NP_524599 NP_001263131 DDBJ / EMBL / GenBank • AA201540 AAA28305 AAF57104 AAM49860 AGB96510 AW941548 AY118491 CZ487840 CZ487841 DD177576 M55533 Entrez Gene - A searchable database of RefSeq genes. • 43669 UniProtKB/Swiss-Prot • P20905
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • G protein-coupled receptor, rhodopsin-like (IPR000276) Dopamine receptor family (IPR000929) GPCR, rhodopsin-like, 7TM (IPR017452) 5-Hydroxytryptamine receptor family (IPR002231) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD04507
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0004573 DroID - A comprehensive database of gene and protein interactions. • FBgn0004573 DRSC - Results from RNAi screens. • FBgn0004573 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004573 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12073-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004573 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43669 modMine - Data generated by the modENCODE project. • FBgn0004573
Synonyms & Secondary IDs ( 23 )
Reported As
Symbol Synonym	5-HT7 (Guan et al., 2011, Perkins et al., 2009.8.10, Rodriguez Moncalvo and Campos, 2009, Mackay et al., 2012) 5HT-7 (Guan et al., 2011) 5HT7 (Dierick and Greenspan, 2007) 5-HT7Dro (Maroteaux, 1995.5.31, Johnson et al., 2009) 5-HT7 (Tierney, 2001, Kahsai et al., 2012, Johnson et al., 2011, Luo et al., 2012) 5-HT7Dro (Becnel et al., 2008, Becnel et al., 2011, Johnson et al., 2011) 5HT7Dro (Kerr et al., 2004) 5-HT7Dro (Tierney, 2001) 5-HTdro1 (Obosi et al., 1996) 5-HT7Dro (Johnson et al., 2009) 5-HT-dro (Tierney, 2001) 5HT-dro (Saudou et al., 1990, ) 5HT-dro1 (Tierney, 2001, Boschert et al., 1991, Boschert et al., 1991, ) 5-HTdro1 (Tierney, 2001) 5-HT-dro1 (Tierney, 2001) 5htdror (Feng et al., 1996) 5HT-R1   CG12073 (Keleman et al., 2009.8.5, Ni et al., 2010.12.1) Dm5HTdro1 (Blenau and Baumann, 2001) DRO1 (Han et al., 1998)
Name Synonym	Serotonin receptor (Ma et al., 2001, Becnel et al., 2011) Serotonin receptor 1   Serotonin receptor 7
Secondary FlyBase IDs
References ( 54 )
Generate a list of	All references relating to this gene ( 54 )
List References by type	Research paper  ( 22 ) Supplementary material  ( 3 ) Review  ( 2 ) Personal communication to FlyBase  ( 17 ) Abstract  ( 3 ) FlyBase analysis  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 ) DNA/RNA sequence record  ( 1 )
Recent research papers ( 7 )
	Kahsai et al., 2012, Neuroscience 208: 11--26 Distribution of metabotropic receptors of serotonin, dopamine, GABA, glutamate, and short neuropeptide F in the central complex of Drosophila. [FBrf0217851] Luo et al., 2012, Cell. Molec. Life Sci. 69(3): 471--484 Insulin-producing cells in the brain of adult Drosophila are regulated by the serotonin 5-HT(1A) receptor. [FBrf0217219] Mackay et al., 2012, Nature 482(7384): 173--178 The Drosophila melanogaster Genetic Reference Panel. [FBrf0217434] Vesala et al., 2012, Insect Mol. Biol. 21(1): 107--118 Cold tolerance and cold-induced modulation of gene expression in two Drosophila virilis group species with different distributions. [FBrf0217233] Becnel et al., 2011, PLoS ONE 6(6): e20800 The Serotonin 5-HT(7)Dro Receptor Is Expressed in the Brain of Drosophila, and Is Essential for Normal Courtship and Mating. [FBrf0213968] Guan et al., 2011, Learn. Mem. 18(4): 191--206 Altered gene regulation and synaptic morphology in Drosophila learning and memory mutants. [FBrf0213277] Johnson et al., 2011, Neuroscience 192: 372--381 Serotonin receptor activity is necessary for olfactory learning and memory in Drosophila melanogaster. [FBrf0215034] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...