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Gene Dmel\bgcn

General Information
Symbol	Dmel\bgcn	Species	D. melanogaster
Name	benign gonial cell neoplasm	Annotation symbol	CG30170
Feature type	protein_coding_gene	FlyBase ID	FBgn0004581
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	b(2)gcn, CG10331
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	60A4-60A4	Sequence location	2R:19,740,801..19,746,314 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene benign gonial cell neoplasm is referred to in FlyBase by the symbol Dmel\bgcn (CG30170, FBgn0004581). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: translation repressor activity, nucleic acid binding. There is experimental evidence that it is involved in the biological process: germ-line stem cell maintenance; oogenesis. 15 alleles are reported. The phenotypes of these alleles are annotated with: stem cell fusome; cystocyte; male germline stem cell; germline stem cell; fusome; germline cell; testis; gonad; female germline stem cell; germarium. It has one annotated transcript and one annotated polypeptide. Protein features are: Ankyrin repeat; Ankyrin repeat-containing domain; Domain of unknown function DUF1605; Helicase-associated domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed at stages throughout the pupal period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult testis. Comments on Affy2 ProbeSet: ProbeSet 1629714_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of bgcn. Gene sequence location is 2R:19740801..19746314.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	bgcn: benign gonial cell neoplasm Gametocyte differentiation defective; gonial proliferation unchecked; gonads of both males and females become engorged with gonial cells. Ovarioles appear sausage like; testes smaller than normal. Autonomous in transplants of young adult ovaries and testes into body cavity of wild-type females. pep: peppercorn (T. Schupbach) Female sterile; homozygous females contain many small egg chambers in their ovaries, which seem blocked in early stages of oogenesis. Follicle cells nevertheless synthesize a very small, round chorion around these egg chambers, giving them the appearance of small round peppercorns.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Richter et al., 2011, Nat. Cell Biol. 13(9): 1029--1039 Sequence features HFA04063 HFA04062 BKN45005 BKN26752
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 60A4-60A4   Limits computationally determined from genome sequence between P{lacW}eIF6k13214 and P{lacW}kenk11035&P{EP}CG17658EP730
Experimentally Determined Cytological Location
Cytogenetic map Notes References 60A3-60A3     (Ohlstein, 2000.4.13) 60A-60A   (determined by in situ hybridisation)   (Ohlstein et al., 2000)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)	shu (Munn and Steward, 2000)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\bgcn for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) bgcn-RA FBtr0072232  NM_079108   4021   1215
Additional Transcript Data & Comments
Reported size (kB)	4.1 (northern blot) (Ohlstein et al., 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein bgcn-PA   FBpp0072141   139.3   1215   7.15     NP_523832   AAF47077
Additional Polypeptide Data & Comments
Reported size (kDa)	1215 (aa); 139 (kD) (Ohlstein et al., 2000)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ankyrin repeat (IPR002110) Helicase-associated domain (IPR007502) Domain of unknown function DUF1605 (IPR011709) Ankyrin repeat-containing domain (IPR020683)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF47077   AF255662 AAF91348   AY089246 AAL89984   BF494623   CO265112   EC072774   EF055932 ABK32574   EF055933 ABK32575   EF055934 ABK32576   EF055935 ABK32577   EF055936 ABK32578   EF055937 ABK32579   EF055938 ABK32580   EF055939 ABK32581   EF055940 ABK32582   EF055941 ABK32583   EF055942 ABK32584   EF055943 ABK32585   EF055954 ABK32596   EF055955 ABK32597   EF055956 ABK32598   EF055957 ABK32599   EF055958 ABK32600   EF055959 ABK32601   EF055960 ABK32602   EF055961 ABK32603   EF055962 ABK32604   EF055963 ABK32605   EF055964 ABK32606   EF055965 ABK32607   X97775
UniProtKB/Swiss-Prot	Q9W1I2
UniProtKB/TrEMBL	Q8T4D2 A1YJU7 A1YJU8 A1YJW9 A1YJU6 A1YJV5 A1YJV0 A1YJW8 A1YJV6 A1YJX6 A1YJX3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference adult stage | male     (Ohlstein et al., 2000) adult stage & oogenesis   germarium   (Ohlstein et al., 2000) cystocyte   (Ohlstein et al., 2000) female germline stem cell   (Ohlstein et al., 2000) cystoblast   (Ohlstein et al., 2000)
Additional Descriptive Data
	bgcn transcripts are abundant in males and very rare in females. By in sity hybridization, they are detected in 5-8 cells at the tip of the germarium. The expression occurs in the germline stem cells, the cystoblasts, and perhaps very young cystocytes. (Ohlstein et al., 2000)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0004581    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0004581 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed at stages throughout the pupal period, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0004581 expression level Developmental Stage   Expression Level embryo 00-02hr    26 embryo 02-04hr    46 embryo 04-06hr    116 embryo 06-08hr    46 embryo 08-10hr    50 embryo 10-12hr    44 embryo 12-14hr    31 embryo 14-16hr    34 embryo 16-18hr    27 embryo 18-20hr    20 embryo 20-22hr    30 embryo 22-24hr    34 larva L1    46 larva L2    27 larva L3 12hr old    53 larva L3 puffstage 1-2    96 larva L3 puffstage 3-6    214 larva L3 puffstage 7-9    212 white prepupae new    233 white prepupae 12hr    411 white prepupae 24hr    636 pupae 2d postWPP    608 pupae 3d postWPP    486 pupae 4d postWPP    509 adult male 01day    757 adult male 05day    1244 adult male 30day    1210 adult female 01day    33 adult female 05day    22 adult female 30day    21 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    26 embryo 02-04hr    46 embryo 04-06hr  (116) embryo 06-08hr    46 embryo 08-10hr    50 embryo 10-12hr    44 embryo 12-14hr    31 embryo 14-16hr    34 embryo 16-18hr    27 embryo 18-20hr    20 embryo 20-22hr    30 embryo 22-24hr    34 larva L1    46 larva L2    27 larva L3 12hr old    53 larva L3 puffstage 1-2    96 larva L3 puffstage 3-6  (214) larva L3 puffstage 7-9  (212) white prepupae new  (233) white prepupae 12hr  (411) white prepupae 24hr  (636) pupae 2d postWPP  (608) pupae 3d postWPP  (486) pupae 4d postWPP  (509) adult male 01day  (757) adult male 05day  (1244) adult male 30day  (1210) adult female 01day    33 adult female 05day    22 adult female 30day    21 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    26 embryo 02-04hr    46 embryo 04-06hr    116 embryo 06-08hr    46 embryo 08-10hr    50 embryo 10-12hr    44 embryo 12-14hr    31 embryo 14-16hr    34 embryo 16-18hr    27 embryo 18-20hr    20 embryo 20-22hr    30 embryo 22-24hr    34 larva L1    46 larva L2    27 larva L3 12hr old    53 larva L3 puffstage 1-2    96 larva L3 puffstage 3-6    214 larva L3 puffstage 7-9    212 white prepupae new    233 white prepupae 12hr    411 white prepupae 24hr    636 pupae 2d postWPP    608 pupae 3d postWPP    486 pupae 4d postWPP    509 adult male 01day    757 adult male 05day    1244 adult male 30day    1210 adult female 01day    33 adult female 05day    22 adult female 30day    21 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    26 embryo 02-04hr    46 embryo 04-06hr    116 embryo 06-08hr    46 embryo 08-10hr    50 embryo 10-12hr    44 embryo 12-14hr    31 embryo 14-16hr    34 embryo 16-18hr    27 embryo 18-20hr    20 embryo 20-22hr    30 embryo 22-24hr    34 larva L1    46 larva L2    27 larva L3 12hr old    53 larva L3 puffstage 1-2    96 larva L3 puffstage 3-6    214 larva L3 puffstage 7-9    212 white prepupae new    233 white prepupae 12hr    411 white prepupae 24hr    636 pupae 2d postWPP    608 pupae 3d postWPP    486 pupae 4d postWPP    509 adult male 01day    757 adult male 05day    1244 adult male 30day    1210 adult female 01day    33 adult female 05day    22 adult female 30day    21 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    26 embryo 02-04hr    46 embryo 04-06hr    116 embryo 06-08hr    46 embryo 08-10hr    50 embryo 10-12hr    44 embryo 12-14hr    31 embryo 14-16hr    34 embryo 16-18hr    27 embryo 18-20hr    20 embryo 20-22hr    30 embryo 22-24hr    34 larva L1    46 larva L2    27 larva L3 12hr old    53 larva L3 puffstage 1-2    96 larva L3 puffstage 3-6    214 larva L3 puffstage 7-9    212 white prepupae new    233 white prepupae 12hr    411 white prepupae 24hr    636 pupae 2d postWPP    608 pupae 3d postWPP    486 pupae 4d postWPP    509 adult male 01day    757 adult male 05day    1244 adult male 30day    1210 adult female 01day    33 adult female 05day    22 adult female 30day    21 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0004581 expression level Developmental Stage   Expression Level embryo 00-02hr    26 embryo 02-04hr    46 embryo 04-06hr    116 embryo 06-08hr    46 embryo 08-10hr    50 embryo 10-12hr    44 embryo 12-14hr    31 embryo 14-16hr    34 embryo 16-18hr    27 embryo 18-20hr    20 embryo 20-22hr    30 embryo 22-24hr    34 larva L1    46 larva L2    27 larva L3 12hr old    53 larva L3 puffstage 1-2    96 larva L3 puffstage 3-6    214 larva L3 puffstage 7-9    212 white prepupae new    233 white prepupae 12hr    411 white prepupae 24hr    636 pupae 2d postWPP    608 pupae 3d postWPP    486 pupae 4d postWPP    509 adult male 01day    757 adult male 05day    1244 adult male 30day    1210 adult female 01day    33 adult female 05day    22 adult female 30day    21 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    26 embryo 02-04hr    46 embryo 04-06hr  116 embryo 06-08hr    46 embryo 08-10hr    50 embryo 10-12hr    44 embryo 12-14hr    31 embryo 14-16hr    34 embryo 16-18hr    27 embryo 18-20hr    20 embryo 20-22hr    30 embryo 22-24hr    34 larva L1    46 larva L2    27 larva L3 12hr old    53 larva L3 puffstage 1-2    96 larva L3 puffstage 3-6  (214) larva L3 puffstage 7-9  (212) white prepupae new  (233) white prepupae 12hr  (411) white prepupae 24hr  (636) pupae 2d postWPP  (608) pupae 3d postWPP  (486) pupae 4d postWPP  (509) adult male 01day  (757) adult male 05day  (1244) adult male 30day  (1210) adult female 01day    33 adult female 05day    22 adult female 30day    21 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    26 embryo 02-04hr    46 embryo 04-06hr    116 embryo 06-08hr    46 embryo 08-10hr    50 embryo 10-12hr    44 embryo 12-14hr    31 embryo 14-16hr    34 embryo 16-18hr    27 embryo 18-20hr    20 embryo 20-22hr    30 embryo 22-24hr    34 larva L1    46 larva L2    27 larva L3 12hr old    53 larva L3 puffstage 1-2    96 larva L3 puffstage 3-6    214 larva L3 puffstage 7-9    212 white prepupae new    233 white prepupae 12hr    411 white prepupae 24hr    636 pupae 2d postWPP    608 pupae 3d postWPP    486 pupae 4d postWPP    509 adult male 01day    757 adult male 05day    1244 adult male 30day    1210 adult female 01day    33 adult female 05day    22 adult female 30day    21 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    26 embryo 02-04hr    46 embryo 04-06hr    116 embryo 06-08hr    46 embryo 08-10hr    50 embryo 10-12hr    44 embryo 12-14hr    31 embryo 14-16hr    34 embryo 16-18hr    27 embryo 18-20hr    20 embryo 20-22hr    30 embryo 22-24hr    34 larva L1    46 larva L2    27 larva L3 12hr old    53 larva L3 puffstage 1-2    96 larva L3 puffstage 3-6    214 larva L3 puffstage 7-9    212 white prepupae new    233 white prepupae 12hr    411 white prepupae 24hr    636 pupae 2d postWPP    608 pupae 3d postWPP    486 pupae 4d postWPP    509 adult male 01day    757 adult male 05day    1244 adult male 30day    1210 adult female 01day    33 adult female 05day    22 adult female 30day    21 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    26 embryo 02-04hr    46 embryo 04-06hr    116 embryo 06-08hr    46 embryo 08-10hr    50 embryo 10-12hr    44 embryo 12-14hr    31 embryo 14-16hr    34 embryo 16-18hr    27 embryo 18-20hr    20 embryo 20-22hr    30 embryo 22-24hr    34 larva L1    46 larva L2    27 larva L3 12hr old    53 larva L3 puffstage 1-2    96 larva L3 puffstage 3-6    214 larva L3 puffstage 7-9    212 white prepupae new    233 white prepupae 12hr    411 white prepupae 24hr    636 pupae 2d postWPP    608 pupae 3d postWPP    486 pupae 4d postWPP    509 adult male 01day    757 adult male 05day    1244 adult male 30day    1210 adult female 01day    33 adult female 05day    22 adult female 30day    21 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0004581    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0004581 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0004581 expression level Tissue   Expression Level Larval Central Nervous System    10.35 Larval Midgut    5.6 Larval Hindgut no informative data Larval Malpighian Tubules    5.9 Larval Fat Body no informative data Larval Salivary Gland    3.9 Larval Trachea    9.175 Larval Carcass    9.2 Adult Head    5.2 Adult Eye    2.625 Adult Brain    4 Adult Thoracic-Abdominal Ganglion    7.1 Adult Crop no informative data Adult Midgut    6.6 Adult Hindgut    9.1 Adult Malpighian Tubules    7.4 Adult Fat Body no informative data Adult Salivary Gland    8.4 Adult Heart    4.6 Adult VirginFemale Spermatheca    9 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    4.8 Adult Testis    302.8 Adult Male Accessory Gland    18.7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    10.35 Larval Midgut    5.6 Larval Hindgut no informative data Larval Malpighian Tubules    5.9 Larval Fat Body no informative data Larval Salivary Gland    3.9 Larval Trachea    9.175 Larval Carcass    9.2 Adult Head    5.2 Adult Eye    2.625 Adult Brain    4 Adult Thoracic-Abdominal Ganglion    7.1 Adult Crop no informative data Adult Midgut    6.6 Adult Hindgut    9.1 Adult Malpighian Tubules    7.4 Adult Fat Body no informative data Adult Salivary Gland    8.4 Adult Heart    4.6 Adult VirginFemale Spermatheca    9 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    4.8 Adult Testis    302.8 Adult Male Accessory Gland    18.7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    10.35 Larval Midgut    5.6 Larval Hindgut no informative data Larval Malpighian Tubules    5.9 Larval Fat Body no informative data Larval Salivary Gland    3.9 Larval Trachea    9.175 Larval Carcass    9.2 Adult Head    5.2 Adult Eye    2.625 Adult Brain    4 Adult Thoracic-Abdominal Ganglion    7.1 Adult Crop no informative data Adult Midgut    6.6 Adult Hindgut    9.1 Adult Malpighian Tubules    7.4 Adult Fat Body no informative data Adult Salivary Gland    8.4 Adult Heart    4.6 Adult VirginFemale Spermatheca    9 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    4.8 Adult Testis    302.8 Adult Male Accessory Gland    18.7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    10.35 Larval Midgut    5.6 Larval Hindgut no informative data Larval Malpighian Tubules    5.9 Larval Fat Body no informative data Larval Salivary Gland    3.9 Larval Trachea    9.175 Larval Carcass    9.2 Adult Head    5.2 Adult Eye    2.625 Adult Brain    4 Adult Thoracic-Abdominal Ganglion    7.1 Adult Crop no informative data Adult Midgut    6.6 Adult Hindgut    9.1 Adult Malpighian Tubules    7.4 Adult Fat Body no informative data Adult Salivary Gland    8.4 Adult Heart    4.6 Adult VirginFemale Spermatheca    9 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    4.8 Adult Testis    302.8 Adult Male Accessory Gland    18.7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0004581 expression level Tissue   Expression Level Larval Central Nervous System    10.35 Larval Midgut    5.6 Larval Hindgut no informative data Larval Malpighian Tubules    5.9 Larval Fat Body no informative data Larval Salivary Gland    3.9 Larval Trachea    9.175 Larval Carcass    9.2 Adult Head    5.2 Adult Eye    2.625 Adult Brain    4 Adult Thoracic-Abdominal Ganglion    7.1 Adult Crop no informative data Adult Midgut    6.6 Adult Hindgut    9.1 Adult Malpighian Tubules    7.4 Adult Fat Body no informative data Adult Salivary Gland    8.4 Adult Heart    4.6 Adult VirginFemale Spermatheca    9 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    4.8 Adult Testis    302.8 Adult Male Accessory Gland    18.7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    10.35 Larval Midgut    5.6 Larval Hindgut no informative data Larval Malpighian Tubules    5.9 Larval Fat Body no informative data Larval Salivary Gland    3.9 Larval Trachea    9.175 Larval Carcass    9.2 Adult Head    5.2 Adult Eye    2.625 Adult Brain    4 Adult Thoracic-Abdominal Ganglion    7.1 Adult Crop no informative data Adult Midgut    6.6 Adult Hindgut    9.1 Adult Malpighian Tubules    7.4 Adult Fat Body no informative data Adult Salivary Gland    8.4 Adult Heart    4.6 Adult VirginFemale Spermatheca    9 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    4.8 Adult Testis    302.8 Adult Male Accessory Gland    18.7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    10.35 Larval Midgut    5.6 Larval Hindgut no informative data Larval Malpighian Tubules    5.9 Larval Fat Body no informative data Larval Salivary Gland    3.9 Larval Trachea    9.175 Larval Carcass    9.2 Adult Head    5.2 Adult Eye    2.625 Adult Brain    4 Adult Thoracic-Abdominal Ganglion    7.1 Adult Crop no informative data Adult Midgut    6.6 Adult Hindgut    9.1 Adult Malpighian Tubules    7.4 Adult Fat Body no informative data Adult Salivary Gland    8.4 Adult Heart    4.6 Adult VirginFemale Spermatheca    9 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    4.8 Adult Testis    302.8 Adult Male Accessory Gland    18.7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    10.35 Larval Midgut    5.6 Larval Hindgut no informative data Larval Malpighian Tubules    5.9 Larval Fat Body no informative data Larval Salivary Gland    3.9 Larval Trachea    9.175 Larval Carcass    9.2 Adult Head    5.2 Adult Eye    2.625 Adult Brain    4 Adult Thoracic-Abdominal Ganglion    7.1 Adult Crop no informative data Adult Midgut    6.6 Adult Hindgut    9.1 Adult Malpighian Tubules    7.4 Adult Fat Body no informative data Adult Salivary Gland    8.4 Adult Heart    4.6 Adult VirginFemale Spermatheca    9 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    4.8 Adult Testis    302.8 Adult Male Accessory Gland    18.7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut no informative data Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop no informative data Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    5.2   NA  Eye    2.625   NA  Brain    4   10.35  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    7.1   NA  Crop    no informative data   5.6  Midgut    6.6   no informative data  Hindgut    9.1   5.9  Malpighian Tubules    7.4   no informative data  Fat Body    no informative data   3.9  Salivary Gland    8.4   NA  Heart    4.6   9.175  Trachea    NA   NA  VirginFemale Spermatheca    9   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    4.8   NA  Testis    302.8   NA  Male Accessory Gland    18.7   9.2  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_28
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004581 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG30170-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for bgcn Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable bgcn1 bgcnQS2 bgcnz2-1185 bgcnz2-1748 bgcnz2-3112 viable, with Scer\GAL4pnr-MD237 bgcnGD10012 Sterility Allele female sterile bgcn1 bgcnQS2 bgcnQW34 female sterile | recessive bgcn1 bgcnoe1 bgcnQS2 bgcnQW34 bgcnz2-1185 bgcnz2-1748 bgcnz2-3112 male sterile | recessive bgcn1 bgcnoe1 bgcnQS2 bgcnz2-1185 bgcnz2-1748 bgcnz2-3112 Other Phenotypes Allele cytokinesis defective bgcnQS2 hyperplasia bgcnQS2 meiotic cell cycle defective bgcnQS2 tumorigenic bgcn1 bgcnQS2 bgcnQW34 Phenotype manifest in Allele cystocyte bgcn1 female germline stem cell bgcnQS2 fusome bgcn1 germarium bgcn1 germline cell bgcn1 bgcnQS2 bgcnz2-1185 bgcnz2-1748 bgcnz2-3112 germline stem cell bgcn1 bgcnQS2 gonad bgcn1 bgcnQS2 bgcnoe1 bgcnz2-1185 bgcnz2-1748 bgcnz2-3112 male germline stem cell bgcnQS2 ovary | adult stage bgcnQS2 bgcnQW34 stem cell fusome bgcnQS2 testis bgcnQS2
Classical Alleles ( 11 )
For All Classical Alleles Show
Allele of bgcn Class Mutagen Stocks Known lesion bgcn1 ethyl methanesulfonate 5 Yes bgcnKG08129 1 -- bgcnSH1616 1 -- bgcnQS2 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes bgcnoe1 P-element activity 0 -- bgcnQW34 ethyl methanesulfonate 0 -- bgcnunspecified 0 -- bgcnz2-0702 ethyl methanesulfonate 0 -- bgcnz2-1185 0 Yes bgcnz2-1748 0 Yes bgcnz2-3112 0 Yes
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of bgcn Class Mutagen Stocks Known lesion bgcnGD10012 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes bgcnKK106752 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes bgcnbgcnP.T:Avic\GFP 0 Yes bgcnhs.PO in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)b23 (Munn and Steward, 2000, Ohlstein et al., 2000) Df(2R)BSC600 (Christensen et al., 2008.9.3) Df(2R)BSC610 (Christensen et al., 2008.9.3) Df(2R)BSC660 (Christensen et al., 2008.12.28) Df(2R)BSC695 (Christensen et al., 2008.12.28) Df(2R)bw-D23 (Schupbach and Wieschaus, 1991) Df(2R)bw-S46 (Schupbach and Wieschaus, 1991)
Not disrupted in	Df(2R)OV1 (Ohlstein et al., 2000)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10012} NA P{KK106752} NA heat-shock construct P{hs-bgcn.O} NA characterization construct P{bgcn-GFP} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}bgcnoe1 No P{lacW}wibgSH1616 No miscellaneous insertions P{SUPor-P}bgcnKG08129 NA
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function
CV term Evidence References
translation repressor activity, nucleic acid binding inferred from direct assay (Shen et al., 2009)
Biological Process
CV term Evidence References
germ-line stem cell maintenance inferred from direct assay (Li et al., 2009) oogenesis inferred from mutant phenotype (Schupbach and Wieschaus, 1991)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
helicase activity inferred from electronic annotation with InterPro:IPR007502 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Lasko, 2000)
Biological Process
CV term Evidence References
cystoblast division non-traceable author statement (Swiss-Prot Project Members, 2000.10.1) traceable author statement (Williamson and Lehmann, 1996) fusome organization traceable author statement (Deng and Lin, 2001) germ cell development traceable author statement (Fuller, 1998) male meiosis traceable author statement (Fuller, 1998) spermatogenesis traceable author statement (Fuller, 1998) spermatogonial cell division traceable author statement (Deng and Lin, 2001)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions bgcn allele Gene References bgcn1 bam (Ohlstein et al., 2000) bgcnQS2 bam (Gonczy et al., 1997) zpg (Gilboa et al., 2003)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 71021 DroID - A comprehensive database of gene and protein interactions. • FBgn0004581 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 47873
Orthologs
Genome-wide drosophilid orthologs	Dana\GF12453 Dere\bgcn Dgri\GH20199 Dmoj\GI20725 Dper\GL10928 Dpse\GA15695 Dsec\GM15503 Dsim\bgcn Dvir\GJ20461 Dwil\GK15867 Dyak\bgcn
Curated drosophilid orthologs	Dere\bgcn (Bauer DuMont et al., 2006.10.11) Dpse\GA15695   Dsan\bgcn (Bauer DuMont et al., 2006.10.11) Dsim\bgcn (Flores et al., 2007, Bauer DuMont et al., 2006.10.11) Dtei\bgcn (Bauer DuMont et al., 2006.10.11) Dyak\bgcn (Bauer DuMont et al., 2006.10.11)
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0085838 FBgn0217870 FBgn0207601 FBgn0085884 FBgn0170421 FBgn0075712 FBgn0148538 FBgn0143460 FBgn0127663 FBgn0085883 FBgn0089490
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	6054 bgcn1/SM5 14687 y1 w67c23; P{SUPor-P}bgcnKG08129 29502 w*; P{FRT(whs)}G13 P{lacW}wibgSH1616 bgcnSH1616, l(2)SH1616SH1616/CyO
Kyoto	108568 bgcn1/SM5 101302 b1 bgcn1 / SM1 101843 w1 ; b1 bgcn1 / SM1 102021 w1 ; b1 bgcn1 / SM6a ; TM6B
VDRC	v108334 P{KK106752}VIE-260B v25590 w1118; P{GD10012}v25590 v25591 w1118; P{GD10012}v25591
Genomic Clones ( 1 )
	BACR05F24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 3 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT03323
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	31583 EK141547
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004581 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 47873
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: bgcn CG10331 (McKearin, 2000.8.3, FlyBase, 1996-) Source for merge of: bgcn PNBP (Millburn, 2000.10.11)
Additional comments	Source for merge of bgcn CG10331 was sequence comparison (date:000815). (FlyBase Genome Annotators, 2002-2003, FlyBase, 1996-)
Other Comments
	bgcn is essential for the localization of bam protein to the fusome. (Lavoie et al., 1999) bam and bgcn cooperatively regulate cystoblast differentiation by controlling localization of bam protein to the fusome. (Lavoie et al., 1999) Germ cells lacking bgcn become trapped in a stem cell-like state. (Lavoie et al., 1999) Mosaic analysis demonstrates bam and bgcn act autonomously in the germline to restrict germ cell proliferation during spermatogenesis. Results suggest bam and bgcn regulate progression through the male germline stem cell lineage by cell-intrinsically restricting the proliferation of amplifying germ cells. bgcn function is not required for the proper expression of bam protein. (Gonczy et al., 1997) Germ cells accumulating in bam or bgcn mutants testis most resemble amplifying germ cells, because they undergo incomplete cytokinesis and progress through the cell cycle in synchrony within a cyst. (Gonczy et al., 1997) Mutants display germline hyperplastic phenotype. (Mechler, 1994) The bgcn locus affects early oogenesis: mutations cause the production of few, defective germ cells. (Schupbach and Wieschaus, 1991)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079108 RefSeq (Proteins) • NP_523832 DDBJ / EMBL / GenBank • AAF47077 AAF91348 AAL89984 ABK32574 ABK32575 ABK32576 ABK32577 ABK32578 ABK32579 ABK32580 ABK32581 ABK32582 ABK32583 ABK32584 ABK32585 ABK32596 ABK32597 ABK32598 ABK32599 ABK32600 ABK32601 ABK32602 ABK32603 ABK32604 ABK32605 ABK32606 ABK32607 AF255662 AY089246 BF494623 EF055932 EF055933 EF055934 EF055935 EF055936 EF055937 EF055938 EF055939 EF055940 EF055941 EF055942 EF055943 EF055954 EF055955 EF055956 EF055957 EF055958 EF055959 EF055960 EF055961 EF055962 EF055963 EF055964 EF055965 X97775 Entrez Gene - A searchable database of RefSeq genes. • 47873 UniProtKB/Swiss-Prot • Q9W1I2 UniProtKB/TrEMBL • A1YJU6 A1YJU7 A1YJU8 A1YJV0 A1YJV5 A1YJV6 A1YJW8 A1YJW9 A1YJX3 A1YJX6 Q8T4D2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ankyrin repeat (IPR002110) Helicase-associated domain (IPR007502) Domain of unknown function DUF1605 (IPR011709) Ankyrin repeat-containing domain (IPR020683)
Linkouts
	BioGRID - A database of protein and genetic interactions • 71021 DroID - A comprehensive database of gene and protein interactions. • FBgn0004581 DRSC - Results from RNAi screens. • FBgn0004581 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004581 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG30170-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004581 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 47873 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 47873 modMine - Data generated by the modENCODE project. • FBgn0004581 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0085838 FBgn0217870 FBgn0207601 FBgn0085884 FBgn0170421 FBgn0075712 FBgn0148538 FBgn0143460 FBgn0127663 FBgn0085883 FBgn0089490
Synonyms & Secondary IDs ( 26 )
Reported As
Symbol Synonym	b(2)cgn (Mechler, 1990) b(2)gcn (Gateff et al., 1996, Gateff et al., 1996, Watson et al., 1994, Mechler, 1994, Gateff, 1994, Loffler et al., 1990, Gateff and Mechler, 1989) bcgn (Wakimoto et al., 2004) ben(2)gcn   bgcn (Mukai et al., 2006, Terry et al., 2006, Richter et al., 2011, Christensen et al., 2008.9.3, Bauer DuMont et al., 2007, Sturgill et al., 2007, Christensen et al., 2008.9.3, Christensen et al., 2008.12.28, Christensen et al., 2008.12.28, Parma et al., 2007, Jung et al., 2007, Xie et al., 2005, Li et al., 2009, Shen et al., 2009, Insco et al., 2009, Vibranovski et al., 2009, Insco et al., 2009, Jin et al., 2008, Gan et al., 2010, Janic et al., 2010, Wasbrough et al., 2010, Wasbrough et al., 2010) Bgcn (Flores et al., 2007, Maines et al., 2008, Li et al., 2009, Kim et al., 2010) BGCN (Fuller and Spradling, 2007) CG10330 (McKearin, 2000.8.3, ) CG10331 (Dimova et al., 2003, McKearin, 2000.8.3, ) cg10331 (Lasko, 2000) CG30170 (Keleman et al., 2009.8.5, Vibranovski et al., 2009) fs(2)eo6   fs(2)eo-C   fs(2)eoQS2   gcn   pep (Schupbach and Wieschaus, 1991, ) PNBP (Lukacsovich et al., 1999, ) unnamed (Protin, 1996.5.9)
Name Synonym	benign-(2)-gonial-cell-neoplasm   benign gonial (Kim et al., 2010) benign gonial cell neoplasia (Mukai et al., 2006) benign gonial cell neoplasm (Flores et al., 2007, Terry et al., 2006, Bauer DuMont et al., 2007, Fuller and Spradling, 2007, Parma et al., 2007, Jung et al., 2007, Li et al., 2009, Vibranovski et al., 2009, Gan et al., 2010, Wasbrough et al., 2010) cell neoplasm (Kim et al., 2010) gonial-cell-neoplasm   peppercorn   Putative nuclear binding protein (Lukacsovich et al., 1999)
Secondary FlyBase IDs
	FBgn0000965 FBgn0001096 FBgn0003066 FBgn0026784 FBgn0034917 FBgn0050170
References ( 103 )
Generate a list of	All references relating to this gene ( 103 )
List References by type	Research paper  ( 36 ) Supplementary material  ( 5 ) Review  ( 22 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 14 ) FlyBase analysis  ( 4 ) DNA/RNA sequence record  ( 7 ) Protein sequence record  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 5 )
	Richter et al., 2011, Nat. Cell Biol. 13(9): 1029--1039 The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements. [FBrf0215050] Gan et al., 2010, Genome Biol. 11(4): R42 Monovalent and unpoised status of most genes in undifferentiated cell-enriched Drosophila testis. [FBrf0211027] Janic et al., 2010, Science 330(6012): 1824--1827 Ectopic expression of germline genes drives malignant brain tumor growth in Drosophila. [FBrf0212713] Kim et al., 2010, J. Biol. Chem. 285(7): 4741--4746 Direct inhibition of pumilo activity by bam and bgcn in Drosophila germ line stem cell differentiation. [FBrf0209919] Wasbrough et al., 2010, J. Proteomics 73(11): 2171--2185 The Drosophila melanogaster sperm proteome-II (DmSP-II). [FBrf0211978] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...