Band 4.1 protein with three potential SH3-binding sites - localization to adherens junctions allows Expanded to exert effects on multiple processes involved in disc development, including effects on cell proliferation, cell fate determination, and tissue polarity
Gene model reviewed during 5.43
Gene model reviewed during 5.52
Forms a complex with Kibra and Mer (PubMed:20159598). Interacts (via RXPPXY motif) with Kibra (via domain WW 1) (PubMed:20159598). Interacts with Mer and Hpo (via SARAH domain) (PubMed:20159598). Interacts with Schip1; the interaction results in recruitment of Schip1 to the apical cell membrane (PubMed:26954546). Interacts with ack and yki (PubMed:27462444).
Phosphorylated by Ack at several tyrosines including Tyr-227, Tyr-423, Tyr-679, Tyr-766 and Tyr-1103.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ex using the Feature Mapper tool.
ex protein is localized to the extreme apical cell surface.
GBrowse - Visual display of RNA-Seq signalsView Dmel\ex in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene is tested in an S2 cell phosphorylation experiment to assess teh hpo signal transduction pathway.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
ex has a common role in all disc tissues and can negatively regulate tissue growth, induce apoptosis, and perturb planar polarity.
Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland.
Clonal analysis reveals that ex functions in the apical cell domain to regulate the growth rate of imaginal discs.
Mutants display hyperplastic phenotype, with imaginal disc overgrowth.
The ex gene is necessary for proper growth control of imaginal discs.
Presumed additional alleles obtained by mobilization of P-element. All are recessive lethals that die during early larval stages.