Gene Dmel\Eig71Ed

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General Information

Symbol

Dmel\Eig71Ed

Species

D. melanogaster

Name

Ecdysone-induced gene 71Ed

Annotation symbol

CG7350

Feature type

protein_coding_gene

FlyBase ID

FBgn0004591

Created / Updated

2003-12-01/2003-12-01

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

71E5-71E5

Sequence location

3L:15,645,644..15,646,204 [+]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

The gene Ecdysone-induced gene 71Ed is referred to in FlyBase by the symbol Eig71Ed (CG7350, FBgn0004591). It has the cytological map location 71E5. Its sequence location is 3L:15645644..15646204. Its molecular function is unknown. It is involved in the biological processes: autophagic cell death; salivary gland cell autophagic cell death. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

71E5-71E5

Limits computationally determined from genome sequence between P{EP}Tfb2^EP572 and P{lacW}th^j5C8&P{PZ}Mbs⁰³⁸⁰²

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

71C-71E

(determined by in situ hybridisation)

(Wright et al., 1996)

71E3-71E5

(determined by in situ hybridisation)

(Restifo and Guild, 1986)

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

In direction of increasing cytology: Eig71Ea- Eig71Eb+ Eig71Ec- Eig71Ed+ Eig71Ee- Eig71Ef- Eig71Eg+ Eig71Eh- Eig71Ei+ Eig71Ej- Eig71Ek+

(Wright et al., 1996)

Gene Order (overall orientation not stated)

References

Overall orientation not stated: Eig71Ea- Eig71Eb+ Eig71Ec- Eig71Ed+ Eig71Ee- Eig71Ef- Eig71Eg+

(Restifo and Guild, 1986)

Overall orientation not stated: Eig71Ea- Eig71Eb+ Eig71Ec- Eig71Ed+ Eig71Ee- Eig71Ef- Eig71Eg+ Eig71Eh- Eig71Ei+ Eig71Ej- Eig71Ek+

(Crossgrove et al., 1996)

Gene Model & Products

Please see the GBrowse view of Dmel\Eig71Ed for information on other features

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Eig71Ed-RA

FBtr0075572

NM_079367

416

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Eig71Ed-PA

FBpp0075325

11.4

8.73

NP_524091

AAF49598

Additional Polypeptide Data & Comments

Reported size (kD)

Comments

External Data

Linkouts

PANTHER - Protein classification by function, families, and pathways

•

FBgn0004591

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Insect protein of unknown function (IPR003475)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Q27241

Maps to

Does NOT map to

Identified with

LP04160

(BDGP Project Members, 2000-)

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

DEDB - Drosophila exon database: splicing graphs

•

4005

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0004591

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0004591

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0004591

Alleles & Phenotypes

Summary of Allele Phenotypes

Phenotype manifest in

Allele

Classical Alleles ( 0 )

For All Classical Alleles Show

Allele of Eig71Ed	Class	Mutagen	Stocks	Known lesion

Alleles Carried on Transgenic Constructs ( 2 )

For All Alleles Carried on Transgenic Constructs Show

Allele of Eig71Ed	Class	Mutagen	Stocks	Known lesion
Eig71Ed^GD15751		in vitro construct \| RNAi in vitro construct \| regulatory fusion	1	Yes
Eig71Ed^GD512		in vitro construct \| RNAi in vitro construct \| regulatory fusion	2	Yes

Aneuploid Aberrations

Useful deficiency

Df(3L)Brd6

Useful duplication

Dp(3;3)M71

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD15751}

P{GD512}

Insertions

Type of insertions

Name

Expression data

Related Comments

Please look at the allele reports for the complete phenotype data

The RNA transcribed from this gene shows a decrease in length during the period in which it accumulates. This is due to a progressively shorter poly(A) tail.

(Restifo and Guild, 1986)

Eig71Ea, Eig71Eb, Eig71Ec, Eig71Ed, Eig71Ee and Eig71Ef have very reduced levels of transcript accumulation in hemizygous br^rbp-1 larvae and pupae compared to wild type.

(Guay and Guild, 1991)

Ecdysteroid-regulated gene.

(Andres et al., 1993)

71E region contains a cluster of 11 developmentally regulated genes. The transcriptional structure, gene organisation and expression pattern are studied.

(Wright et al., 1996)

The br complex (BR-C) early gene encoded by the Z1 isoform (rbp) directly activates late gene transcription (genes from the 71E salivary glands late puff) by interacting with late gene cis-acting regulatory elements and this interaction is responsible for the temporal linkage of early and late ecdysone-induced gene expression.

(Crossgrove et al., 1996)

Gene Ontology: Function, Process & Cellular Component ( 2 )

Molecular Function

CV term

Evidence

References

Biological Process

CV term

Evidence

References

autophagic cell death

inferred from expression pattern

(Gorski et al., 2003)

salivary gland cell autophagic cell death

inferred from expression pattern

(Gorski et al., 2003)

Cellular Component

CV term

Evidence

References

Sequence Ontology: Class of Gene

protein_coding_gene

nuclear_gene

Interactions & Pathways

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

Eig71Ed allele

Gene

References

External Data

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

65020

Orthologs

Genome-wide drosophilid orthologs

Dere\GG15918

Dsec\GM25550

Dsim\GD14563

Dwil\GK15124

Dyak\GE23155

Curated drosophilid orthologs

Dpse\GA20285

Linkouts

Functional Complementation between Species

Inter-Species Misexpression Data

Produces phenotype in

Produces NO phenotype in

Stocks & Reagents

Stocks Listed in FlyBase ( 3 )

VDRC

v42506

w¹¹¹⁸; P{GD512}v42506

v40805

w¹¹¹⁸ P{GD15751}v40805

v42504

w¹¹¹⁸; P{GD512}v42504/TM3

Genomic Clones ( 2 )

cDNA Clones ( 42 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

LP04160

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Affy Oligo

Linkouts

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0004591

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0004591

Antibody Information

Other Information

Discoverer

Etymology

Identification

Position Effect Variegation Data

Relationship to Other Genes

Source for database identity of

Source for database merge of

Source for merge of: Eig71Ed BcDNA:LP04160 Source for merge of Eig71Ed BcDNA:LP04160 was a shared cDNA (date:030728).

(FlyBase, 1996-)

Additional comments

Comments About Role

Comments About Molecular Function

Other Comments

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NM_079367

RefSeq (Proteins)

•

NP_524091

DDBJ / EMBL / GenBank

•

UniProtKB/TrEMBL

•

Q27241

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Insect protein of unknown function (IPR003475)

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

65020

DEDB - Drosophila exon database: splicing graphs

•

4005

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0004591

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0004591

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0004591

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0004591

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0004591

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0004591

PANTHER - Protein classification by function, families, and pathways

•

FBgn0004591

Synonyms & Secondary IDs ( 11 )

Reported As

Symbol Synonym

BcDNA:LP04160

CG7350

Eig71Ed

(Zraly et al., 2006, Reiter et al., 2007)

gene IV

(Restifo and Guild, 1986)

gene-IV

(Restifo and Guild, 1986)

L71

(Thummel, 2001, Mendez et al., 2002)

L71-4

(White et al., 1999, Wright, 1995.4.6, Wright, 1995.3.29, Crossgrove et al., 1996, Wright et al., 1996, Fletcher and Thummel, 1995, Fletcher and Thummel, 1995, )

Name Synonym

71E-Gene-IV

(Andres et al., 1993)

Ecdysone-induced gene 71Ed

Gene IV

(Andres and Thummel, 1992)

Secondary FlyBase IDs

FBgn0063120

References ( 24 )

Generate a list of

All references relating to this gene ( 24 )

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Recent research papers ( 2 )

Reiter et al., 2007, Fly 1(3): 164--171: Accentuate the Negative. [FBrf0200136]
Zraly et al., 2006, J. Biol. Chem. 281(46): 35305--35315: Hormone-response genes are direct in vivo regulatory targets of Brahma (SWI/SNF) complex function. [FBrf0192654]

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Recent reviews (0)

All reviews listed in FlyBase were published before 2006

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