FB2020_06, released Dec 22, 2020

Gene: Dmel\zfh1

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General Information
Symbol
Dmel\zfh1
Species
D. melanogaster
Name
Zn finger homeodomain 1
Annotation Symbol
CG1322
Feature Type
protein_coding_gene
FlyBase ID
FBgn0004606
Gene Model Status
Current
Stock Availability
16 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Also Known As

zfh-1, zinc finger homeodomain 1, Zinc-finger homeodomain protein 1, l(3)00865

Key Links
Genomic Location
Cytogenetic map
100A4-100A5
Sequence location
3R:30,765,926..30,789,202 [+]
Recombination map

3-101

RefSeq locus
NT_033777 REGION:30765926..30789202
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (19 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from direct assay
(Postigo et al., 1999)
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding
inferred from direct assay
(Postigo et al., 1999)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN001227065
(assigned by GO_Central )
(Gaudet et al., 2011)
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN001227065
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (14 terms)
Terms Based on Experimental Evidence (12 terms)
CV Term
Evidence
References
involved_in axonal fasciculation
inferred from mutant phenotype
(Lee and Lundell, 2007)
involved_in garland nephrocyte differentiation
inferred from mutant phenotype
(Sellin et al., 2006)
involved_in germ cell migration
inferred from mutant phenotype
(Moore et al., 1998)
involved_in hemocyte development
inferred from mutant phenotype
(Frandsen et al., 2008)
involved_in lymph gland development
inferred from mutant phenotype
(Sellin et al., 2006)
involved_in mesoderm development
inferred from expression pattern
(Lai et al., 1991)
inferred from genetic interaction with FLYBASE:sna; FB:FBgn0003448
(Lai et al., 1991)
inferred from genetic interaction with FLYBASE:twi; FB:FBgn0003900
(Lai et al., 1991)
involved_in motor neuron axon guidance
inferred from mutant phenotype
(Zarin et al., 2014, Lee and Lundell, 2007, Layden et al., 2006)
involved_in muscle cell cellular homeostasis
inferred from mutant phenotype
(Boukhatmi and Bray, 2018)
involved_in negative regulation of muscle cell differentiation
inferred from mutant phenotype
(Boukhatmi and Bray, 2018)
involved_in negative regulation of transcription by RNA polymerase II
inferred from direct assay
(Postigo et al., 1999)
involved_in nervous system development
inferred from expression pattern
(Lai et al., 1991)
involved_in somatic stem cell division
inferred from mutant phenotype
(Leatherman and DiNardo, 2008)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in anatomical structure development
inferred from biological aspect of ancestor with PANTHER:PTN001227065
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN001227065
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Lai et al., 1991)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in chromatin
inferred from biological aspect of ancestor with PANTHER:PTN001227065
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family. (P28166)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
C2H2 ZINC FINGER TRANSCRIPTION FACTORS -
Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys2His2 zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).
ZINC FINGER HOMEOBOX TRANSCRIPTION FACTORS -
Zinc finger homeobox transcription factors are sequence-specific DNA binding proteins that regulate transcription. This class includes proteins with homeodomain and C2H2 and C2H2-like zinc finger motifs. (Adapted from FBrf0232555 and PMID:18797923).
Protein Function (UniProtKB)
Involved in the development of the embryonic central nervous system, embryonic mesoderm and adult musculature.
(UniProt, P28166)
Summary (Interactive Fly)

transcription factor - zinc finger domain and homeodomain - mutation results in various degrees of local errors in mesodermal cell fate or positioning - a transcription factor network, comprised of , and , induces the expression of the Unc5 and Beaten-path guidance receptors and the Fasciclin 2 and Neuroglian adhesion molecules to guide individual dorsal motor neuron axons

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\zfh1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.55

Low-frequency RNA-Seq exon junction(s) not annotated.

gene_with_stop_codon_read_through ; SO:0000697

Stop-codon suppression (UAG) postulated; FBrf0216884.

Gene model reviewed during 5.44

Gene model reviewed during 5.56

Sequence Ontology: Class of Gene
gene_with_stop_codon_read_through
(Jungreis et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
zfh1-RA
FBtr0085702
NM_170523
3560
747
zfh1-RB
FBtr0085701
NM_057502
6522
1054
zfh1-RE
FBtr0331180
NM_170522
6522
1206
Additional Transcript Data and Comments
Reported size (kB)

7.5 (northern blot)

(Fortini et al., 1991)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
zfh1-PA
FBpp0085064
83.8
747
7.54
NP_733402
AAF57084
zfh1-PB
FBpp0085063
116.6
1054
7.15
NP_476850
AAF57083
zfh1-PE
FBpp0303607
133.0
1206
7.52
NP_733401
AAN14258
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)

1060 (aa); 145 (kD observed); 117 (kD predicted)

(Fortini et al., 1991)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\zfh1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
central nervous system | restricted
(Lai et al., 1991)
mesoderm
(Lai et al., 1991)
cardioblast
(Lai et al., 1991)
embryonic precursor cell of adult muscle
(Lai et al., 1991)
primordial germ cell
(Lai et al., 1991)
embryonic/larval visceral muscle
(Lai et al., 1991)
embryonic/larval somatic muscle
(Lai et al., 1991)
gonad
(Lai et al., 1991)
embryonic/larval dorsal vessel
(Lai et al., 1991)
embryonic stage 9 -- 11
visceral mesoderm | restricted
(Kusch and Reuter, 1999)
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
head mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
trunk mesoderm anlage
(Fisher et al., 2012)
embryonic stage 7 -- 8
anterior endoderm anlage
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
mesectoderm anlage
(Kearney et al., 2004)
embryonic stage 9 -- 10
head mesoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
cardiogenic mesoderm
(Fisher et al., 2012)
embryonic neuroblast of ventral nerve cord primordium
(Fisher et al., 2012)
fat body/gonad primordium
(Fisher et al., 2012)
lateral cord glial cell
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
midline ventral glial cell
(Fisher et al., 2012)
pericardial cell primordium

Comment: reported as pericardial cell specific anlage

(Fisher et al., 2012)
plasmatocyte primordium

Comment: reported as plasmatocytes anlage

(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic central brain glial cell
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
embryonic leading edge cell
(Fisher et al., 2012)
embryonic/larval fat body
(Fisher et al., 2012)
embryonic/larval lymph gland
(Fisher et al., 2012)
embryonic/larval pericardial cell
(Fisher et al., 2012)
lateral cord glial cell
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
ventral nerve cord
(Fisher et al., 2012)
dorsal median cell
(Kearney et al., 2004)
larval midline neuron
(Kearney et al., 2004)
embryonic stage 11
MP1 neuron

Comment: transient expression

(Wheeler et al., 2006)
MP3 precursor

Comment: transient expression

(Wheeler et al., 2006)
VUM precursor | subset
(Wheeler et al., 2006)
neuroblast MNB

Comment: transient expression

(Wheeler et al., 2006)
embryonic ventral midline neuroblast
(Kang et al., 2009)
embryonic stage 13
VUM motor neuron | subset
(Wheeler et al., 2006)
embryonic stage 17
VUM motor neuron
(Wheeler et al., 2006)
embryonic stage 5 -- 6
mesectoderm
(Kearney et al., 2004)
embryonic stage 9 -- 12
midline primordium | subset
(Kearney et al., 2004)
embryonic stage 1 -- 2
pole plasm
(Yatsu et al., 2008)
embryonic stage 4 -- 5
primordial germ cell
(Yatsu et al., 2008)
embryonic stage 14 -- 16
primordial germ cell
(Yatsu et al., 2008)
embryonic stage 12 -- 14
embryonic midline of ventral nerve cord
(Kang et al., 2009)
embryonic stage 15
neuron of embryonic/larval central nervous system
(Kang et al., 2009)
Additional Descriptive Data

zfh1 is expressed in neuroblasts along the ventral midline at embryonic stage 11 and then symmetrically along the midline at stages 13 and 15. It is then expressed in CNS neurons at stage 15.

(Kang et al., 2009)

Expression assayed at stages 9, 11, 13, and 17. Expression may be continuous between assayed stages in some tissues.

(Wheeler et al., 2006)

The zfh1 transcript distribution pattern corresponds closely to that of zfh1 protein.

(Lai et al., 1991)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
distribution deduced from reporter
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 16 -- 17
scutellar pulsatile organ

Comment: precursor

(Tögel et al., 2008)
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
visceral muscle
(Lai et al., 1991)
mesoderm
(Lai et al., 1991)
embryonic precursor cell of adult muscle
(Lai et al., 1991)
cardioblast
(Bodmer, 1993, Lai et al., 1991)
central nervous system | restricted
(Lai et al., 1991)
embryonic/larval dorsal vessel
(Tsigkari et al., 2012, Bodmer, 1993, Lai et al., 1991)
VUM neuron
(Lai et al., 1991)
ventral intersegmental neuron
(Lai et al., 1991)
primordial germ cell
(Lai et al., 1991)
gonad

Comment: somatic component

(Tsigkari et al., 2012, Lai et al., 1991)
lateral ipsisegmental neuron
(Lai et al., 1991)
pericardial cell
(Bodmer, 1993)
RP neuron
(Lai et al., 1991)
aCC neuron
(Lai et al., 1991)
somatic muscle
(Lai et al., 1991)
embryonic pericardial cell
• nucleus

Comment: expressed in non-eve-expressing pericardial cells

(Su et al., 1999)
embryonic/larval central nervous system | restricted
(Tsigkari et al., 2012)
trunk mesoderm
(Tsigkari et al., 2012)
embryonic stage 15 -- 17
GW neuron
(Lundell et al., 2003)
embryonic stage 12 -- 15
RP2 motor neuron
(Bhat and Apsel, 2004)
adult stage | male & spermatogenesis
cyst progenitor cell
(Chen et al., 2013, Issigonis et al., 2009)
larval stage
dorsal neurohemal organ
(Vogler and Urban, 2008)
apterous-expressing neuron of the lateral cluster of the thorax Ap4
(Vogler and Urban, 2008)
adult stage | male
cyst progenitor cell
(Leatherman and DiNardo, 2008)
male germline cyst
(Leatherman and DiNardo, 2008)
embryonic stage 14 -- 16
peripheral glial cell
(Ohayon et al., 2009)
embryonic peripheral glial cell 1 -- embryonic peripheral glial cell 12
(Ohayon et al., 2009)
third instar larval stage
adepithelial cell of wing disc
(Boukhatmi and Bray, 2018)
adult stage
plasmatocyte
(Boukhatmi and Bray, 2018)
thoracic adult muscle precursor cell
(Boukhatmi and Bray, 2018)
embryonic stage 15
embryonic precursor cell of adult muscle
(Figeac et al., 2010)
oogenesis & adult stage | female
stalk follicle cell
(Chang et al., 2013)
embryonic stage 17
GW neuron
(Karcavich and Doe, 2005)
embryonic stage 13 -- 16
B-subperineurial glial cell of abdomen

Comment: in 10-50% of examined hemisegments

(Beckervordersandforth et al., 2008)
A-subperineurial glial cell
(Beckervordersandforth et al., 2008)
lateral ventral subperineurial glial cell
(Beckervordersandforth et al., 2008)
medial dorsal subperineurial glial cell
(Beckervordersandforth et al., 2008)
dorsal lateral subperineurial glial cell
(Beckervordersandforth et al., 2008)
ventral lateral subperineurial glial cell
(Beckervordersandforth et al., 2008)
medial ventral subperineurial glial cell
(Beckervordersandforth et al., 2008)
dorsal channel glial cell

Comment: in 10-50% of examined hemisegments

(Beckervordersandforth et al., 2008)
ventral channel glial cell
(Beckervordersandforth et al., 2008)
embryonic/larval neuron
(Beckervordersandforth et al., 2008)
Additional Descriptive Data

zfh1 is expressed in muscle precursor cells in the wing disc. In early stages, expression is uniform but in later stages levels are reduced in cells with high ct expression that will give rise to the direct flight muscles. The cells in which zfh1 expression remains high give rise to the indirect flight muscles. zfh1 expression is observed in sparse nuclei embedded in the lamina in adult IFM. These are persistant muscle progenitor cells that remain undifferentiated in the adult. zfh1 is also expressed in another cell population in muscle that were identified as plasmatocytes.

(Boukhatmi and Bray, 2018)

zfh1 is expressed in all AMPs (adult muscle precursor cells.

(Figeac et al., 2010)

zfh1 is expressed in all peripheral glial cells at embryonic stages 14 and 16 and in ePG12 but is excluded from other neurons and accessory cells.

(Ohayon et al., 2009)

zfh1 protein levels are high in cyst progenitor cells and then drop in cyst cell daughters.

(Leatherman and DiNardo, 2008)

Markers that uniquely identify the cells of the NB3-7 lineage were used to examine the serotonin expressing cell lineages.

(Lundell et al., 2003)

zfh1 protein is initially expressed in a subset of heart precursor cells. Later expression is observed in all cells that form the dorsal vessel, cardial cells as well as pericardial cells.

(Bodmer, 1993)

zfh1 protein is abundant in staged extracts from embryos between 3 and 18 hours. zfh1 protein is first detected in the presumptive procephalic mesoderm and then in the ventral mesoderm and pole cells. In late stage 8, strong staining is seen in a ~30 cell-wide band of ventral mesoderm. In stage 11, zfh1 protein is detected mainly in ectodermally-derived CNS structures and is thought to be present in most identifiable motor neurons including the aCC, RP, VUM, ventral intersegmental, and lateral ipsisegmental neurons. In stage 13, zfh1 protein is abundant in the CNS as well as in some mesodermally derived structures, including the dorsal vessel, gonadal support cells, and laterally located adult muscle precursor cells of the thoracic and abdominal segments. At stage 15, two rows of dorsal vessel cardioblasts are strongly stained as dorsal closure is completed. The CNS has condensed and shows staining of segmentally repeated subsets of neurons. Weak staining persists in the somatic and visceral musculature.

(Lai et al., 1991)
Marker for
 
RP2 motor neuron
(Bhat and Apsel, 2004)
VUM motor neuron
(Fontana and Crews, 2012)
cyst cell of testis
(Srinivasan et al., 2012)
cyst progenitor cell
(Chen et al., 2013, Leatherman and Dinardo, 2010, Issigonis et al., 2009, Sheng et al., 2009)
embryonic pericardial cell
(Albrecht et al., 2006, Su et al., 1999)
embryonic precursor cell of adult muscle
(Figeac et al., 2010)
embryonic/larval cardial cell
(Bodmer, 1993)
motor neuron
(Sanyal, 2009)
stalk follicle cell
(Chang et al., 2013)
Subcellular Localization
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Lai et al., 1991)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\zfh1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 27 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 22 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of zfh1
Transgenic constructs containing regulatory region of zfh1
Deletions and Duplications ( 19 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4A3.eya
lethal | recessive
lethal - all die before end of embryonic stage | recessive
viable, with Scer\GAL4A3.eya, Scer\GAL80ts.αTub84B
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female sterile, with Scer\GAL4bab1-Pgal4-2
female sterile, with Scer\GAL4tj.PU
Other Phenotypes
Allele
neuroanatomy defective
neuroanatomy defective, with Scer\GAL4eg-Mz360
neuroanatomy defective, with Scer\GAL4elav-C155
neuroanatomy defective, with Scer\GAL4s.gcm
neuroanatomy defective (with zfh15)
neuroanatomy defective (with zfh175.26)
sleep defective | adult stage, with Scer\GAL4elav.PLu
some die during embryonic stage | recessive
visible | adult stage, with Scer\GAL4GMR35H09
visible | heat sensitive
visible | male limited, with Scer\GAL4Bx-MS1096
wild-type
Phenotype manifest in
Allele
A1-7 dorsal acute muscle 1, with Scer\GAL4how-24B
A1-7 dorsal oblique muscle 1, with Scer\GAL4how-24B
abdominal posterior fascicle & axon, with Scer\GAL4elav-C155
abdominal segmental nerve
abdominal segmental nerve (with zfh15)
abdominal segmental nerve (with zfh175.26)
cardioblast
cyst progenitor cell | somatic clone
dMP2 neuron & axon, with Scer\GAL422B
embryonic/larval dorsal trunk
embryonic/larval dorsal vessel
embryonic/larval lymph gland
embryonic/larval lymph gland | embryonic stage
embryonic/larval pericardial cell
embryonic/larval somatic muscle
embryonic somatic muscle (with Df(3R)GC14)
EW1 neuron & axon, with Scer\GAL4eg-Mz360
EW2 neuron & axon, with Scer\GAL4eg-Mz360
EW3 neuron & axon, with Scer\GAL4eg-Mz360
EW neuron, with Scer\GAL4eg-Mz360
eye | heat sensitive
fat body/gonad primordium
garland cell
germline cell
gonad | precursor
gonadal sheath proper primordium
gonadal sheath proper primordium | male (with Df(3R)GC14)
hemocyte | embryonic stage
indirect flight muscle, with Scer\GAL4GMR35H09
intersegmental nerve
intersegmental nerve (with zfh15)
intersegmental nerve (with zfh175.26)
macrochaeta & thorax | conditional ts
male germline cell | supernumerary, with Scer\GAL4A3.eya, Scer\GAL80ts.αTub84B
motor nerve & axon, with Scer\GAL4s.gcm
muscle cell | supernumerary, with Scer\GAL41151
myoblast, with Scer\GAL41151
nucleus | adult stage, with Scer\GAL4GMR35H09
ovary, with Scer\GAL4bab1-Pgal4-2
ovary, with Scer\GAL4tj.PU
pericardial cell
presumptive embryonic/larval central nervous system | heat sensitive
somatic cell of testis | supernumerary, with Scer\GAL4A3.eya, Scer\GAL80ts.αTub84B
testis, with Scer\GAL4A3.eya, Scer\GAL80ts.αTub84B
wing, with Scer\GAL4GMR35H09
wing | male limited, with Scer\GAL4Bx-MS1096
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ZEB2
10 of 15
Yes
Yes
Hsap\ZEB1
9 of 15
No
Yes
Hsap\HINFP
1 of 15
No
No
Hsap\MECOM
1 of 15
No
No
Hsap\PRDM16
1 of 15
No
No
Hsap\ZNF91
1 of 15
No
No
Hsap\ZNF236
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Zeb1
9 of 15
Yes
Yes
Mmus\Zeb2
9 of 15
Yes
Yes
1  
Mmus\Hinfp
1 of 15
No
No
Mmus\Mecom
1 of 15
No
No
Mmus\Prdm16
1 of 15
No
No
Mmus\Zfp236
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (3)
Rnor\Zeb2
8 of 13
Yes
Yes
Rnor\Zeb1
7 of 13
No
Yes
Rnor\Hinfp
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (3)
Xtro\zeb1
5 of 12
Yes
Yes
Xtro\zeb2
5 of 12
Yes
Yes
Xtro\hinfp
1 of 12
No
No
Danio rerio (Zebrafish) (7)
Drer\zeb2a
8 of 15
Yes
Yes
Drer\zeb1a
7 of 15
No
Yes
Drer\zeb1b
6 of 15
No
Yes
Drer\zeb2b
6 of 15
No
Yes
Drer\hinfp
1 of 15
No
No
Drer\zgc:112083
1 of 15
No
No
Drer\znf1004
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\zag-1
9 of 15
Yes
Yes
Cele\Y56A3A.28
1 of 15
No
Yes
Cele\ZK686.5
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\MIG1
1 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\scr1
1 of 12
Yes
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919027K )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00009138
Drosophila simulans
Dsim\GD21545
Drosophila sechellia
Dsec\GM12904
Drosophila sechellia
Dsec\GM12905
Drosophila erecta
Dere\GG11775
Drosophila yakuba
Dyak\GE10901
Drosophila ananassae
Dana\GF22922
Drosophila pseudoobscura pseudoobscura
Dpse\GA12131
Drosophila persimilis
Dper\GL13515
Drosophila virilis
Dvir\GJ24242
Drosophila mojavensis
Dmoj\GI22121
Drosophila grimshawi
Dgri\GH14214
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150BGD )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17007169
Glossina morsitans
Tsetse fly
Gmor\GMOY006469
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_00562
Mayetiola destructor
Hessian fly
Mdes\Mdes001537
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL002451
Anopheles darlingi
American malaria mosquito
Adar\ADAC000352
Anopheles gambiae
Malaria mosquito
Agam\AGAP000779
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ012784
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0DBO )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA002551
Danaus plexippus
Monarch butterfly
Dple\DPOGS210231-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL005606
Apis florea
Little honeybee
Aflo\2491522772
Apis mellifera
Western honey bee
Amel\GB49657
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP12515
Bombus terrestris
Buff-tailed bumblebee
Bter\15216157
Linepithema humile
Argentine ant
Lhum\LH19365
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0011ec
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG010485
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04155
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00812
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02569
Tribolium castaneum
Red flour beetle
Tcas\TC011114
Pediculus humanus
Human body louse
Phum\PHUM017930
Rhodnius prolixus
Kissing bug
Rpro\RPRC009393
Cimex lectularius
Bed bug
Clec\CLEC010103
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008075
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_15056
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0D9G )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR012800
Ixodes scapularis
Black-legged tick
Isca\ISCW015893
Stegodyphus mimosarum
African social velvet spider
Smim\KFM67857.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g04210
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g04230
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g04220
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_225224
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 3 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ZEB2; zinc finger E-box binding homeobox 2
    10 of 15
    605802
    ZEB1; zinc finger E-box binding homeobox 1
    9 of 15
    189909
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement
    View in Interactions Browser
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    zfh1
    suppressible
    eve
    (Su et al., 1999)
    zfh1
    enhanceable
    eve
    (Zarin et al., 2014)
    zfh1
    enhanceable
    tin
    (Franch-Marro and Casanova, 2000)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    eve
    enhanceable
    zfh1
    (Zarin et al., 2014)
    grn
    suppressible
    zfh1
    (Garces and Thor, 2006)
    Mef2
    suppressible
    zfh1
    (Boukhatmi and Bray, 2018)
    tin
    enhanceable
    zfh1
    (Franch-Marro and Casanova, 2000)
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map

    3-101

    Cytogenetic map
    100A4-100A5
    Sequence location
    3R:30,765,926..30,789,202 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    100A4-100A5
    Limits computationally determined from genome sequence between P{PZ}ncd05884 and P{lacW}l(3)s2500s2500
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    100A1-100A2
    (BDGP Project Members, 1994-1999)
    100A1-100A2
    (determined by in situ hybridisation)
    (Spradling et al., 1999, Lai et al., 1993, Fortini et al., 1991)
    Experimentally Determined Recombination Data
    Location

    3-101

    (FlyBase, 2016)

    3-98.7

    (Comeron et al., 2012)

    3-

    (Moore et al., 1998)
    Left of (cM)
    Right of (cM)
    (Moore et al., 1998)
    Notes
    Stocks and Reagents
    Stocks (16)
    Genomic Clones (25)
    cDNA Clones (70)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       

      monoclonal antibody

      (Bhat and Apsel, 2004)

      polyclonal

      (Lai et al., 1991)
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of

      Source for identity of: zfh1 CG1322

      (Yao, 1999.11)
      Source for database merge of
      Additional comments
      Other Comments

      DNA-protein interactions: genome-wide binding profile assayed for zfh1 protein in 0-12 hr embryos; see mE1_TFBS_zfh1 collection report.

      (Negre et al., 2011)

      zfh1 is required for ventral motor axon exit from the CNS.

      (Layden et al., 2006)

      Expression is enriched in embryonic gonads.

      (Shigenobu et al., 2006)

      RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a greater than three-fold increase in AttA activity in response to heat-killed E.coli after ecdysone treatment in S2 cells.

      (Kleino et al., 2005)

      byn, supported by fkh, mediates the early specification of the caudal visceral mesoderm along with zfh1.

      (Kusch and Reuter, 1999)

      zfh1 is specifically required for the formation of the eve-expressing subset of pericardial cells (EPCs), without affecting the formation of their siblings, the founders of a dorsal body wall muscle (DA1). zfh1 specifies EPC development independently of numb.

      (Su et al., 1999)

      tin is not required for early zfh1 expression throughout the mesoderm or for the refinement of this expression to lateral mesodermal clusters during stage 10. tin activity is required for aspects of zfh1 expression beginning at stage 11.

      (Broihier et al., 1998)

      Loss of zfh1 activity disrupts the development of two distinct mesodermal populations: the caudal visceral mesoderm and the gonadal mesoderm. Ectopic expression of zfh1 is sufficient to induce additional gonadal mesodermal cells and to alter the temporal course of gene expression within these cells.

      (Broihier et al., 1998)

      zfh1 function is required for the transition of germ cells from the endoderm to the mesoderm, suggesting zfh1 is required for interactions between germ cells and somatic gonadal precursors (SGPs). Maternal zfh1 is not required for proper germ cell migration. zfh1 function is also required for aspects of caudal visceral mesoderm-specific gene expression and for the migration of these cells. tin and zfh1 cooperate in the specification of two tissues derived from the lateral mesoderm: the gonadal mesoderm and the fat body. zfh1 is a primary regulator of gonadal mesoderm, as it is both able to promote ectopic gonadal mesoderm formation and to alter the temporal course of gene expression in these cells.

      (Broihier et al., 1998)

      Mutants are isolated in an EMS mutagenesis screen to identify zygotic mutations affecting germ cell migration at discrete points during embryogenesis: mutants exhibit germ cell migration defects.

      (Moore et al., 1998)

      zfh1 is required for the development of both fat body and gonadal mesoderm in the embryo.

      (Moore et al., 1998)

      Identification: Enhancer trap screen designed to discover genes involved in the cellular aspects of defense mechanisms, as well as in melanotic tumor formation processes linked to blood cell disregulation.

      (Braun et al., 1997)

      One of the homeodomain loci identified in a screen for genes encoding DNA binding proteins capable of binding to a consensus Engrailed binding site.

      (Kalionis and O'Farrell, 1993)

      Phenotypic analysis reveals that the gene is not required for the initial segregation of the mesoderm or differentiation of mesodermally derived tissues, but loss of zfh1 function results in varying degrees of local errors in cell fate or positioning.

      (Lai et al., 1993)

      The product of zfh1 possesses one homeodomain and nine C2H2 zinc fingers. The novel arrangement of interspersed homeodomain and zinc-finger motifs in the primary sequences of the zfh1 and zfh2 gene products may signify an unusual mechanism of transcriptional regulation by these products.

      (Fortini et al., 1991)

      Mesodermal expression of zfh1 is largely dependent upon twi and sna.

      (Lai et al., 1991)

      The expression pattern of zfh1 suggests that the protein may be involved in neurogenesis and may have additional functions in mesoderm development.

      (Lai et al., 1991)
      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 54 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      SignaLink - A signaling pathway resource with multi-layered regulatory networks.
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      FlyMine - An integrated database for Drosophila genomics
      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Synonyms and Secondary IDs (22)
      Reported As
      Symbol Synonym
      CG1322
      (Schertel et al., 2013, Guo et al., 2011, Ni et al., 2010.12.1, Hazelett et al., 2009, Keleman et al., 2009.8.5, Krejcí et al., 2009, Perkins et al., 2009)
      ZFH-1
      (Whitworth et al., 2012, Casper et al., 2011, Issigonis and Matunis, 2011, Issigonis et al., 2009, Udolph et al., 2009, Mathews et al., 2006, Tian et al., 2004, Furlong et al., 2001)
      ZFH1
      (Percival-Smith, 2017, Greenspan et al., 2015, Tanentzapf et al., 2007, Lovato et al., 2005)
      ZFh1
      (Ben-Zvi and Volk, 2019)
      Zfh-1
      (Bischof et al., 2018, Monahan and Starz-Gaiano, 2016, Smendziuk et al., 2015, Ocorr et al., 2014, Chen et al., 2013, Morillo Prado et al., 2013, Singh et al., 2013, Wang et al., 2013, Zhang et al., 2013, Lim et al., 2012, Matunis et al., 2012, Morillo Prado et al., 2012, Sano et al., 2012, Tsigkari et al., 2012, Vanderploeg et al., 2012, Wong and Jones, 2012, Zoller and Schulz, 2012, Zhu and Bhat, 2011, Freeman et al., 2010, Leatherman and Dinardo, 2010, Monk et al., 2010, Leal et al., 2009, Sheng et al., 2009, Udolph et al., 2009, Wong et al., 2008, Albrecht et al., 2006, Clark et al., 2006, Nguyen and Frasch, 2006, Zaffran et al., 2006, Karcavich and Doe, 2005, Miskolczi-McCallum et al., 2005, Reim et al., 2005, Garces and Thor, 2004, Yedvobnick et al., 2004, Johnson et al., 2003, Lundell et al., 2003, Cripps and Olson, 2002, Novotny et al., 2002, Stein et al., 2002, Isshiki et al., 2001, Mehta and Bhat, 2001, Tio et al., 2001, Zaffran and Frasch, 2000, Gunthorpe et al., 1999, Su et al., 1999, Chu et al., 1998, Park et al., 1996, Wu et al., 1995, Bodmer, 1993)
      Zfh1
      (Sênos Demarco et al., 2020, Straub et al., 2020, Waghmare et al., 2020, Ismail et al., 2019, La Marca et al., 2019, Sreejith et al., 2019, Drechsler et al., 2018, Losada-Perez, 2018, Richardson and Portela, 2018, Schwartz and Rhiner, 2018, Schwarz et al., 2018, Tamirisa et al., 2018, Zhai et al., 2018, Banisch et al., 2017, Chaturvedi et al., 2017, Pons et al., 2017, Tang et al., 2017, Kotov et al., 2016, Mbodj et al., 2016, Baëza et al., 2015, Dorn and Dorn, 2015, Qian et al., 2015, Stratoulias and Heino, 2015, Tarayrah et al., 2015, Ahmad et al., 2014, Resende et al., 2013, Zhang et al., 2013, Boukhatmi et al., 2012, Matunis et al., 2012, Siddall et al., 2012, Wong and Jones, 2012, Zhu et al., 2012, Bravo-Ambrosio and Kaprielian, 2011, de Cuevas and Matunis, 2011, Zheng et al., 2011, Zhu and Bhat, 2011, Berger et al., 2010, Figeac et al., 2010, Gaziova and Bhat, 2009, Sanyal, 2009, Beckervordersandforth et al., 2008, Vogler and Urban, 2008, Bhat, 2007, Newfeld and Johnson, 2007, Albrecht et al., 2006, Beckett and Baylies, 2006, Betschinger et al., 2006, de Velasco et al., 2006, Gilboa and Lehmann, 2006, Sandmann et al., 2006, Merianda et al., 2005, Alvarez et al., 2003, Vogler and Urban, 2003, Buescher and Chia, 1997, Baylies and Bate, 1996)
      Zfh1a
      (Santiago-Martinez et al., 2006)
      l(3)00865
      (Braun et al., 1997)
      zfh-1
      (Feng et al., 2017, Zarin et al., 2014, Siles et al., 2013, Matunis et al., 2012, Zoller and Schulz, 2012, Okegbe and DiNardo, 2011, Neely et al., 2010, Krejcí et al., 2009, Sheng et al., 2009, DeFalco et al., 2008, Leatherman and DiNardo, 2008, Lee and Lundell, 2007, de Velasco et al., 2006, Liu et al., 2006, Sellin et al., 2006, Tsigari and Skoulakis, 2006, Vogler and Urban, 2006, Lee and Lundell, 2005, Wawersik and Van, 2005, Layden et al., 2004, Santos and Lehmann, 2004, Vogler and Urban, 2004, De Falco et al., 2003, DeFalco et al., 2003, Marhold et al., 2003, Novotny et al., 2001, Starz-Gaiano and Lehmann, 2001, Cheah et al., 2000, Han et al., 1999, Krempler and Brenig, 1999, Lockwood et al., 1999, Mukai et al., 1999, Postigo and Dean, 1999, Postigo et al., 1999, Su et al., 1999, Wai et al., 1999, Zilian et al., 1999, Broihier et al., 1998, Broihier et al., 1998, Buescher et al., 1998, Lehmann et al., 1998, Moore et al., 1998, Moore et al., 1998, Ranganayakulu et al., 1998, Shen, 1998, Skeath and Doe, 1998, Hemavathy et al., 1997, Rongo et al., 1997, Su et al., 1997, Su et al., 1997, Yang et al., 1997, Casal and Leptin, 1996, Abmayr et al., 1995, Justice et al., 1995, Xu et al., 1995, Zaffran et al., 1995, Kalionis and O'Farrell, 1993, Hashimoto et al., 1992, Fortini et al., 1991, Lai et al., 1991)
      zfh1
      (Parniewska and Stocker, 2020, Sun et al., 2020, Camara et al., 2019, Chang et al., 2019, Herrera and Bach, 2019, Li et al., 2019, Shokri et al., 2019, Tiwari et al., 2019, Witt et al., 2019, Wu et al., 2019, Albert et al., 2018, Boukhatmi and Bray, 2018, Lavoy et al., 2018, Karaiskos et al., 2017, Lobell et al., 2017, Transgenic RNAi Project members, 2017-, Bürglin and Affolter, 2016, Peng et al., 2016, Yu et al., 2016, Bivik et al., 2015, Dequéant et al., 2015, Doggett et al., 2015, Enriquez et al., 2015, Li et al., 2015, Schertel et al., 2015, Ashwal-Fluss et al., 2014, Maimon et al., 2014, Rembold et al., 2014, Slattery et al., 2014, Valanne, 2014, Zarin et al., 2014, Aleksic et al., 2013, Bausek, 2013, Chang et al., 2013, Jin et al., 2013, Pancratov et al., 2013, Schertel et al., 2013, Amoyel and Bach, 2012, Fontana and Crews, 2012, Japanese National Institute of Genetics, 2012.5.21, Larschan et al., 2012, Srinivasan et al., 2012, Jungreis et al., 2011, Nègre et al., 2011, Park et al., 2011, Stagg et al., 2011, Vallejo et al., 2011, Flaherty et al., 2010, Frise et al., 2010, Ismat et al., 2010, Neely et al., 2010, The modENCODE Consortium, 2010, The modENCODE Consortium, 2010, Hazelett et al., 2009, Kang et al., 2009, Krejcí et al., 2009, Liu et al., 2009, Ohayon et al., 2009, Sellin et al., 2009, Southall and Brand, 2009, Frandsen et al., 2008, Frise et al., 2008, Rogulja-Ortmann et al., 2008, Tögel et al., 2008, Wheeler et al., 2008, Yatsu et al., 2008, Johnson et al., 2007, Leatherman and DiNardo, 2007, Sellin et al., 2007, Choksi et al., 2006, Friedman and Perrimon, 2006, Garces and Thor, 2006, Layden et al., 2006, Liu et al., 2006, Shigenobu et al., 2006, Wheeler et al., 2006, Burgler and Macdonald, 2005)
      zfl-1
      (Chinnadurai, 2002)
      zhf1
      (Song et al., 2009)
      Name Synonyms
      Zinc Finger Homeodomain 1
      (Wong et al., 2008)
      Zinc-finger homeodomain protein 1
      (Lim et al., 2012, Matunis et al., 2012, Beckervordersandforth et al., 2008)
      Zn finger homeodomain 1
      (Carpenter et al., 2009, Wheeler et al., 2008, Choksi et al., 2006, Liu et al., 2006)
      Zn homeodomain 1
      (Wheeler et al., 2006)
      zinc finger homeodomain 1
      (Enriquez et al., 2015, Wang et al., 2013, DeFalco et al., 2008)
      zinc finger homeodomain protein-1
      (Wawersik and Van, 2005)
      zinc finger homeodomain-1
      (Issigonis et al., 2009)
      zinc-finger homeobox gene
      (Garces and Thor, 2006)
      zinc-finger homeodomain protein 1
      (Rogulja-Ortmann et al., 2008)
      zinc-finger homeodomain1
      (Kang et al., 2009)
      Secondary FlyBase IDs
      • FBgn0010733
      Datasets (1)
      Study focus (1)
      Experimental Role
      Project
      Project Type
      Title
      • bait_protein
      modENCODE_regulation_TFs
      Genome-wide localization of transcription factors by ChIP-chip and ChIP-Seq.
      References (349)