• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\zfh2

General Information
Symbol	Dmel\zfh2	Species	D. melanogaster
Name	Zn finger homeodomain 2	Annotation symbol	CG1449
Feature type	protein_coding_gene	FlyBase ID	FBgn0004607
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	Zfh-2
Genomic Location
Chromosome (arm)	4	Recombination map
Cytogenetic map	102C3-102C4	Sequence location	4:522,442..560,981 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Zn finger homeodomain 2 is referred to in FlyBase by the symbol Dmel\zfh2 (CG1449, FBgn0004607). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: RNA polymerase II regulatory region sequence-specific DNA binding. There is experimental evidence that it is involved in the biological process: nervous system development; imaginal disc-derived wing morphogenesis. 12 alleles are reported. The phenotypes of these alleles are annotated with: wing disc; sclerite; medial costal vein; alula; wing; wing vein L1; wing hinge. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Homeobox; Homeobox, conserved site; Homeodomain-like; Homeodomain-related; Zinc finger, C2H2; Zinc finger, C2H2-like; Zinc finger, C2H2-type/integrase, DNA-binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1627320_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of zfh2. Gene sequence location is 4:522442..560981.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features BKN20913 HFA17178 Controlled Vocabulary Terms RNA polymerase II regulatory region sequence-specific DNA binding
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 102C3-102C4
Experimentally Determined Cytological Location
Cytogenetic map Notes References 102C1-102C2   (determined by in situ hybridisation)   (Fortini et al., 1991)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\zfh2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) zfh2-RA FBtr0089070  NM_079884   10613   3005 zfh2-RB FBtr0307167     11170   3003
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein zfh2-PA   FBpp0088139   332.0   3005   6.57     NP_524623   AAF59339 zfh2-PB   FBpp0297996   331.8   3003   6.59
Additional Polypeptide Data & Comments
Reported size (kDa)	3005 (aa); 332 (kD predicted) (Fortini et al., 1991) 3005 (aa) (Lundell and Hirsh, 1992)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Homeobox, conserved site (IPR017970) Zinc finger, C2H2-type/integrase, DNA-binding (IPR013087) Zinc finger, C2H2-like (IPR015880) Homeobox (IPR001356) Zinc finger, C2H2 (IPR007087) Homeodomain-like (IPR009057) Homeodomain-related (IPR012287)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014135 AAF59339   AC009535   AC010668   AC018478   AF242879   AF242880   AI134433   AI406135   AI533151   AI542796   AW940433   AY060681 AAL28229   AY312816 AAQ67630   AY312817 AAQ67631   AY312818 AAQ67632   AY312819 AAQ67633   AY312820 AAQ67634   AY312821 AAQ67635   AY312822 AAQ67636   AY312823 AAQ67637   AY312824 AAQ67638   AY312825 AAQ67639   AY312826 AAQ67640   AY312827 AAQ67641   AY312828 AAQ67642   AY312829 AAQ67643   AY312830 AAQ67644   AY312831 AAQ67645   AY312832 AAQ67646   AY312833 AAQ67647   AY312834 AAQ67648   AY312835 AAQ67649   AY312836 AAQ67650   AY312837 AAQ67651   AY312838 AAQ67652   AY312839 AAQ67653   BG639715   BT088973   CO178406   CO191104   CO263845   CO267728   CO270367   CO270684   CO280192   CO284497   CO294448   CO295904   CO295935   CO299791   CO299813   CO304677   CO304988   CO306572   CO308213   CO308501   CO311196   CO314100   CO317384   CO317843   CO318193   CO319597   CO320802   CO323063   CO323223   CO327612   CO328835   CO333507   CO340691   CO340734   CO341035   CO341416   CO344839   EC051878   EC053951   EC054366   EC056074   EC057514   EC061800   EC064101   EC065778   EC068656   EC069050   EC071314   EC073183   EC074655   EC075372   EC075640   EC076161   EC083727   EC087127   EC089604   EC195819   EC197314   EC200816   EC202947   EC203144   EC203775   EC204207   EC205394   EC206665   EC213029   EC222209   EC224862   EC226362   EC238165   EC238194   EC238636   EC238968   EC246769   EC248641   EC249031   EC254656   EC254692   EC254735   EC255149   EC258196   EL874403   EL874404   EL874483   EL874484   EL874554   EL874555   EL874626   EL874627   GH942088   GH943661   GH948756   GH955170   GH956185   GH960008   GH961983   GH962177   GH967174   GH967980   GH968773   GH970928   GH972261   GH981106   GH981149   GH983441   GH983950   M63450 AAA29051   U87286
UniProtKB/Swiss-Prot	P28167
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 13 -- 15   presumptive embryonic/larval central nervous system   (Lai et al., 1991) embryonic stage 15   embryonic/larval hindgut   (Lai et al., 1991)
Additional Descriptive Data
	The zfh2 transcript distribution pattern corresponds closely to that of zfh2 protein. (Lai et al., 1991)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference larval stage   abdominal 3 ventro-lateral cluster neuron -- abdominal 6 ventro-lateral cluster neuron   (Lundell and Hirsh, 1992) embryonic/larval central nervous system   (Lundell and Hirsh, 1992) immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   presumptive embryonic/larval central nervous system | lateral   (Lundell and Hirsh, 1992) embryonic stage 13 -- 15   presumptive embryonic/larval central nervous system   (Lai et al., 1991) embryonic stage 15   embryonic/larval hindgut   (Lai et al., 1991) embryonic stage 15 -- 17   EW2 neuron   (Lundell et al., 2003) EW3 neuron   (Lundell et al., 2003) embryonic stage 17   EW2 neuron   (Lundell and Hirsh, 1998) EW3 neuron   (Lundell and Hirsh, 1998) larval stage   abdominal 3 neuroblast dorso-lateral cluster -- abdominal 7 neuroblast dorso-lateral cluster   (Lundell and Hirsh, 1992) third instar larval stage   ventro-lateral serotonergic neuron | subset   (Lundell and Hirsh, 1998) dopaminergic neuron | subset   (Lundell and Hirsh, 1998)
Additional Descriptive Data
	zfh2 protein isexpressed in about 50 cells/segment in the lateral embryonic CNS atpositions consistent with the subsequent location of serotonin cells. Inlarvae, it is expressed in a dispersed pattern in about 20% of the cellsin the ventral ganglion. A subset of these also express Ddc and includedopamine and seratonin neurons. (Lundell and Hirsh, 1992) Markers that uniquely identify the cells of the NB3-7 lineage were used to examine the serotonin expressing cell lineages. (Lundell et al., 2003) zfh2 protein is first detected in the CNS at the middle of germ band retraction. It is present in at least 50 neurons per hemisegment as well as in cells of the brain. It is also detected at lower levels in the hindgut of older embryos (Lai et al., 1991) zfh2 is expressed in the lateral, but not the medial, of the paired ventro-lateral serotonergic neurons. (Lundell and Hirsh, 1998)
Marker for
Subcellular Localization
CV Term	nucleus (Lai et al., 1991)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0004607    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0004607 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0004607 expression level Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    224 embryo 04-06hr    825 embryo 06-08hr    1062 embryo 08-10hr    1413 embryo 10-12hr    882 embryo 12-14hr    2184 embryo 14-16hr    869 embryo 16-18hr    998 embryo 18-20hr    663 embryo 20-22hr    522 embryo 22-24hr    838 larva L1    553 larva L2    308 larva L3 12hr old    184 larva L3 puffstage 1-2    144 larva L3 puffstage 3-6    563 larva L3 puffstage 7-9    904 white prepupae new    900 white prepupae 12hr    974 white prepupae 24hr    1088 pupae 2d postWPP    483 pupae 3d postWPP    205 pupae 4d postWPP    105 adult male 01day    165 adult male 05day    128 adult male 30day    119 adult female 01day    55 adult female 05day    40 adult female 30day    45 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr  (224) embryo 04-06hr  (825) embryo 06-08hr  (1062) embryo 08-10hr  (1413) embryo 10-12hr  (882) embryo 12-14hr  (2184) embryo 14-16hr  (869) embryo 16-18hr  (998) embryo 18-20hr  (663) embryo 20-22hr  (522) embryo 22-24hr  (838) larva L1  (553) larva L2  (308) larva L3 12hr old  (184) larva L3 puffstage 1-2  (144) larva L3 puffstage 3-6  (563) larva L3 puffstage 7-9  (904) white prepupae new  (900) white prepupae 12hr  (974) white prepupae 24hr  (1088) pupae 2d postWPP  (483) pupae 3d postWPP  (205) pupae 4d postWPP  105 adult male 01day  (165) adult male 05day  (128) adult male 30day  (119) adult female 01day    55 adult female 05day    40 adult female 30day    45 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    224 embryo 04-06hr    825 embryo 06-08hr    1062 embryo 08-10hr  1413 embryo 10-12hr    882 embryo 12-14hr  (2184) embryo 14-16hr    869 embryo 16-18hr    998 embryo 18-20hr    663 embryo 20-22hr    522 embryo 22-24hr    838 larva L1    553 larva L2    308 larva L3 12hr old    184 larva L3 puffstage 1-2    144 larva L3 puffstage 3-6    563 larva L3 puffstage 7-9    904 white prepupae new    900 white prepupae 12hr    974 white prepupae 24hr    1088 pupae 2d postWPP    483 pupae 3d postWPP    205 pupae 4d postWPP    105 adult male 01day    165 adult male 05day    128 adult male 30day    119 adult female 01day    55 adult female 05day    40 adult female 30day    45 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    224 embryo 04-06hr    825 embryo 06-08hr    1062 embryo 08-10hr    1413 embryo 10-12hr    882 embryo 12-14hr    2184 embryo 14-16hr    869 embryo 16-18hr    998 embryo 18-20hr    663 embryo 20-22hr    522 embryo 22-24hr    838 larva L1    553 larva L2    308 larva L3 12hr old    184 larva L3 puffstage 1-2    144 larva L3 puffstage 3-6    563 larva L3 puffstage 7-9    904 white prepupae new    900 white prepupae 12hr    974 white prepupae 24hr    1088 pupae 2d postWPP    483 pupae 3d postWPP    205 pupae 4d postWPP    105 adult male 01day    165 adult male 05day    128 adult male 30day    119 adult female 01day    55 adult female 05day    40 adult female 30day    45 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    224 embryo 04-06hr    825 embryo 06-08hr    1062 embryo 08-10hr    1413 embryo 10-12hr    882 embryo 12-14hr    2184 embryo 14-16hr    869 embryo 16-18hr    998 embryo 18-20hr    663 embryo 20-22hr    522 embryo 22-24hr    838 larva L1    553 larva L2    308 larva L3 12hr old    184 larva L3 puffstage 1-2    144 larva L3 puffstage 3-6    563 larva L3 puffstage 7-9    904 white prepupae new    900 white prepupae 12hr    974 white prepupae 24hr    1088 pupae 2d postWPP    483 pupae 3d postWPP    205 pupae 4d postWPP    105 adult male 01day    165 adult male 05day    128 adult male 30day    119 adult female 01day    55 adult female 05day    40 adult female 30day    45 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0004607 expression level Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    224 embryo 04-06hr    825 embryo 06-08hr    1062 embryo 08-10hr    1413 embryo 10-12hr    882 embryo 12-14hr    2184 embryo 14-16hr    869 embryo 16-18hr    998 embryo 18-20hr    663 embryo 20-22hr    522 embryo 22-24hr    838 larva L1    553 larva L2    308 larva L3 12hr old    184 larva L3 puffstage 1-2    144 larva L3 puffstage 3-6    563 larva L3 puffstage 7-9    904 white prepupae new    900 white prepupae 12hr    974 white prepupae 24hr    1088 pupae 2d postWPP    483 pupae 3d postWPP    205 pupae 4d postWPP    105 adult male 01day    165 adult male 05day    128 adult male 30day    119 adult female 01day    55 adult female 05day    40 adult female 30day    45 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr  (224) embryo 04-06hr  (825) embryo 06-08hr  (1062) embryo 08-10hr  (1413) embryo 10-12hr  (882) embryo 12-14hr  (2184) embryo 14-16hr  (869) embryo 16-18hr  (998) embryo 18-20hr  (663) embryo 20-22hr  (522) embryo 22-24hr  (838) larva L1  (553) larva L2  (308) larva L3 12hr old  (184) larva L3 puffstage 1-2  (144) larva L3 puffstage 3-6  (563) larva L3 puffstage 7-9  (904) white prepupae new  (900) white prepupae 12hr  (974) white prepupae 24hr  (1088) pupae 2d postWPP  (483) pupae 3d postWPP  (205) pupae 4d postWPP  105 adult male 01day  (165) adult male 05day  128 adult male 30day  119 adult female 01day    55 adult female 05day    40 adult female 30day    45 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    224 embryo 04-06hr    825 embryo 06-08hr    1062 embryo 08-10hr  1413 embryo 10-12hr    882 embryo 12-14hr  2184 embryo 14-16hr    869 embryo 16-18hr    998 embryo 18-20hr    663 embryo 20-22hr    522 embryo 22-24hr    838 larva L1    553 larva L2    308 larva L3 12hr old    184 larva L3 puffstage 1-2    144 larva L3 puffstage 3-6    563 larva L3 puffstage 7-9    904 white prepupae new    900 white prepupae 12hr    974 white prepupae 24hr    1088 pupae 2d postWPP    483 pupae 3d postWPP    205 pupae 4d postWPP    105 adult male 01day    165 adult male 05day    128 adult male 30day    119 adult female 01day    55 adult female 05day    40 adult female 30day    45 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    224 embryo 04-06hr    825 embryo 06-08hr    1062 embryo 08-10hr    1413 embryo 10-12hr    882 embryo 12-14hr    2184 embryo 14-16hr    869 embryo 16-18hr    998 embryo 18-20hr    663 embryo 20-22hr    522 embryo 22-24hr    838 larva L1    553 larva L2    308 larva L3 12hr old    184 larva L3 puffstage 1-2    144 larva L3 puffstage 3-6    563 larva L3 puffstage 7-9    904 white prepupae new    900 white prepupae 12hr    974 white prepupae 24hr    1088 pupae 2d postWPP    483 pupae 3d postWPP    205 pupae 4d postWPP    105 adult male 01day    165 adult male 05day    128 adult male 30day    119 adult female 01day    55 adult female 05day    40 adult female 30day    45 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    224 embryo 04-06hr    825 embryo 06-08hr    1062 embryo 08-10hr    1413 embryo 10-12hr    882 embryo 12-14hr    2184 embryo 14-16hr    869 embryo 16-18hr    998 embryo 18-20hr    663 embryo 20-22hr    522 embryo 22-24hr    838 larva L1    553 larva L2    308 larva L3 12hr old    184 larva L3 puffstage 1-2    144 larva L3 puffstage 3-6    563 larva L3 puffstage 7-9    904 white prepupae new    900 white prepupae 12hr    974 white prepupae 24hr    1088 pupae 2d postWPP    483 pupae 3d postWPP    205 pupae 4d postWPP    105 adult male 01day    165 adult male 05day    128 adult male 30day    119 adult female 01day    55 adult female 05day    40 adult female 30day    45 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0004607    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0004607 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0004607 expression level Tissue   Expression Level Larval Central Nervous System    82.05 Larval Midgut    3.5 Larval Hindgut    42.3 Larval Malpighian Tubules    2 Larval Fat Body    4.9 Larval Salivary Gland    4.5 Larval Trachea    14.375 Larval Carcass    9 Adult Head    16 Adult Eye    4.6 Adult Brain    63.6 Adult Thoracic-Abdominal Ganglion    45 Adult Crop    6.2 Adult Midgut    4.7 Adult Hindgut    4.6 Adult Malpighian Tubules    3 Adult Fat Body    8.8 Adult Salivary Gland    9.8 Adult Heart    0.65 Adult VirginFemale Spermatheca    4.3 Adult InseminatedFemale Spermatheca    8.6 Adult Ovary    1.3 Adult Testis    1.2 Adult Male Accessory Gland    3.4 Adult Carcass    1.4 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    82.05 Larval Midgut    3.5 Larval Hindgut    42.3 Larval Malpighian Tubules    2 Larval Fat Body    4.9 Larval Salivary Gland    4.5 Larval Trachea    14.375 Larval Carcass    9 Adult Head    16 Adult Eye    4.6 Adult Brain    63.6 Adult Thoracic-Abdominal Ganglion    45 Adult Crop    6.2 Adult Midgut    4.7 Adult Hindgut    4.6 Adult Malpighian Tubules    3 Adult Fat Body    8.8 Adult Salivary Gland    9.8 Adult Heart    0.65 Adult VirginFemale Spermatheca    4.3 Adult InseminatedFemale Spermatheca    8.6 Adult Ovary    1.3 Adult Testis    1.2 Adult Male Accessory Gland    3.4 Adult Carcass    1.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    82.05 Larval Midgut    3.5 Larval Hindgut    42.3 Larval Malpighian Tubules    2 Larval Fat Body    4.9 Larval Salivary Gland    4.5 Larval Trachea    14.375 Larval Carcass    9 Adult Head    16 Adult Eye    4.6 Adult Brain    63.6 Adult Thoracic-Abdominal Ganglion    45 Adult Crop    6.2 Adult Midgut    4.7 Adult Hindgut    4.6 Adult Malpighian Tubules    3 Adult Fat Body    8.8 Adult Salivary Gland    9.8 Adult Heart    0.65 Adult VirginFemale Spermatheca    4.3 Adult InseminatedFemale Spermatheca    8.6 Adult Ovary    1.3 Adult Testis    1.2 Adult Male Accessory Gland    3.4 Adult Carcass    1.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    82.05 Larval Midgut    3.5 Larval Hindgut    42.3 Larval Malpighian Tubules    2 Larval Fat Body    4.9 Larval Salivary Gland    4.5 Larval Trachea    14.375 Larval Carcass    9 Adult Head    16 Adult Eye    4.6 Adult Brain    63.6 Adult Thoracic-Abdominal Ganglion    45 Adult Crop    6.2 Adult Midgut    4.7 Adult Hindgut    4.6 Adult Malpighian Tubules    3 Adult Fat Body    8.8 Adult Salivary Gland    9.8 Adult Heart    0.65 Adult VirginFemale Spermatheca    4.3 Adult InseminatedFemale Spermatheca    8.6 Adult Ovary    1.3 Adult Testis    1.2 Adult Male Accessory Gland    3.4 Adult Carcass    1.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0004607 expression level Tissue   Expression Level Larval Central Nervous System    82.05 Larval Midgut    3.5 Larval Hindgut    42.3 Larval Malpighian Tubules    2 Larval Fat Body    4.9 Larval Salivary Gland    4.5 Larval Trachea    14.375 Larval Carcass    9 Adult Head    16 Adult Eye    4.6 Adult Brain    63.6 Adult Thoracic-Abdominal Ganglion    45 Adult Crop    6.2 Adult Midgut    4.7 Adult Hindgut    4.6 Adult Malpighian Tubules    3 Adult Fat Body    8.8 Adult Salivary Gland    9.8 Adult Heart    0.65 Adult VirginFemale Spermatheca    4.3 Adult InseminatedFemale Spermatheca    8.6 Adult Ovary    1.3 Adult Testis    1.2 Adult Male Accessory Gland    3.4 Adult Carcass    1.4 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    82.05 Larval Midgut    3.5 Larval Hindgut    42.3 Larval Malpighian Tubules    2 Larval Fat Body    4.9 Larval Salivary Gland    4.5 Larval Trachea    14.375 Larval Carcass    9 Adult Head    16 Adult Eye    4.6 Adult Brain    63.6 Adult Thoracic-Abdominal Ganglion    45 Adult Crop    6.2 Adult Midgut    4.7 Adult Hindgut    4.6 Adult Malpighian Tubules    3 Adult Fat Body    8.8 Adult Salivary Gland    9.8 Adult Heart    0.65 Adult VirginFemale Spermatheca    4.3 Adult InseminatedFemale Spermatheca    8.6 Adult Ovary    1.3 Adult Testis    1.2 Adult Male Accessory Gland    3.4 Adult Carcass    1.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    82.05 Larval Midgut    3.5 Larval Hindgut    42.3 Larval Malpighian Tubules    2 Larval Fat Body    4.9 Larval Salivary Gland    4.5 Larval Trachea    14.375 Larval Carcass    9 Adult Head    16 Adult Eye    4.6 Adult Brain    63.6 Adult Thoracic-Abdominal Ganglion    45 Adult Crop    6.2 Adult Midgut    4.7 Adult Hindgut    4.6 Adult Malpighian Tubules    3 Adult Fat Body    8.8 Adult Salivary Gland    9.8 Adult Heart    0.65 Adult VirginFemale Spermatheca    4.3 Adult InseminatedFemale Spermatheca    8.6 Adult Ovary    1.3 Adult Testis    1.2 Adult Male Accessory Gland    3.4 Adult Carcass    1.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    82.05 Larval Midgut    3.5 Larval Hindgut    42.3 Larval Malpighian Tubules    2 Larval Fat Body    4.9 Larval Salivary Gland    4.5 Larval Trachea    14.375 Larval Carcass    9 Adult Head    16 Adult Eye    4.6 Adult Brain    63.6 Adult Thoracic-Abdominal Ganglion    45 Adult Crop    6.2 Adult Midgut    4.7 Adult Hindgut    4.6 Adult Malpighian Tubules    3 Adult Fat Body    8.8 Adult Salivary Gland    9.8 Adult Heart    0.65 Adult VirginFemale Spermatheca    4.3 Adult InseminatedFemale Spermatheca    8.6 Adult Ovary    1.3 Adult Testis    1.2 Adult Male Accessory Gland    3.4 Adult Carcass    1.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    16   NA  Eye    4.6   NA  Brain    63.6   82.05  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    45   NA  Crop    6.2   3.5  Midgut    4.7   42.3  Hindgut    4.6   2  Malpighian Tubules    3   4.9  Fat Body    8.8   4.5  Salivary Gland    9.8   NA  Heart    0.65   14.375  Trachea    NA   NA  VirginFemale Spermatheca    4.3   NA  InseminatedFemale Spermatheca    8.6   NA  Ovary    1.3   NA  Testis    1.2   NA  Male Accessory Gland    3.4   9  Carcass    1.4 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_11
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004607 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1449-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for zfh2 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal zfh21-M707.R zfh22-M371.R lethal | pupal stage, with Scer\GAL4pnr-MD237 zfh2GD4506 semi-lethal | pupal stage, with Scer\GAL4LP30 zfh2dsRNA.Scer\UAS viable zfh22-M390.R viable | poor zfh21-M707.R zfh22-M390.R zfh2MS209 Other Phenotypes Allele visible | adult stage A1, with Scer\GAL4LP30 zfh2dsRNA.Scer\UAS Phenotype manifest in Allele alula zfh2MS209 medial costal vein zfh2MS209 sclerite, with Scer\GAL4LP30 zfh2dsRNA.Scer\UAS wing, with Scer\GAL4LP30 zfh2dsRNA.Scer\UAS wing | proximal zfh22-M390.R zfh21-M707.R zfh2MS209 wing disc zfh2MS209 wing hinge, with Scer\GAL4LP30 zfh2dsRNA.Scer\UAS wing vein L1 zfh2MS209
Classical Alleles ( 9 )
For All Classical Alleles Show
Allele of zfh2 Class Mutagen Stocks Known lesion zfh25-HA-1838 1 -- zfh2c02999a 1 -- zfh2d09602 1 -- zfh2f05624 1 -- zfh2MS209 P-element activity 1 Yes zfh21-M707.R P-element activity 0 -- zfh22-M371.R P-element activity 0 -- zfh22-M390.R P-element activity 0 -- zfh2MS209R20 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of zfh2 Class Mutagen Stocks Known lesion zfh2GD4506 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes zfh2dsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes zfh2KK100817 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(4)C1-7a (Sousa-Neves et al., 2005) Df(4)C1-10a (Sousa-Neves et al., 2005)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4506} NA P{KK100817} NA P{UAS-zfh2.RNAi} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{hsp26-pt-T}zfh21-M707.R NA P{hsp26-pt-T}zfh22-M371.R NA P{hsp26-pt-T}zfh22-M390.R NA P{RS5}zfh25-HA-1838 NA PBac{PB}zfh2c02999a NA PBac{WH}zfh2f05624 NA insertion of mobile activating element P{XP}zfh2d09602 NA insertion of enhancer trap binary system P{GAL4}zfh2MS209 No
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function
CV term Evidence References
RNA polymerase II regulatory region sequence-specific DNA binding inferred from direct assay (Lundell and Hirsh, 1992)
Biological Process
CV term Evidence References
imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Whitworth and Russell, 2003) nervous system development inferred from expression pattern (Lai et al., 1991)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Lai et al., 1991)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
DNA binding non-traceable author statement (Swiss-Prot Project Members, 1994.10.1) traceable author statement (Lai et al., 1991) sequence-specific DNA binding transcription factor activity inferred from electronic annotation with InterPro:IPR001356 (FlyBase Curators et al., 2004-) zinc ion binding inferred from electronic annotation with InterPro:IPR007087, InterPro:IPR015880 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
central nervous system development non-traceable author statement (Swiss-Prot Project Members, 1994.10.1) regulation of transcription, DNA-dependent inferred from sequence or structural similarity with UniProtKB:Q15911 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity with UniProtKB:Q15911 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1994.10.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions zfh2 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68628 DroID - A comprehensive database of gene and protein interactions. • FBgn0004607 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43795
Orthologs
Genome-wide drosophilid orthologs	Dana\GF19021 Dere\GG16389 Dgri\GH24013 Dmoj\GI14048 Dper\GL18142 Dpse\GA13024 Dsim\GD24406 Dvir\GJ19746 Dwil\GK13603 Dyak\GE14550
Curated drosophilid orthologs	Dpse\GA13024   Dsim\zfh2
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL002335-PA Aedes aegypti (mosquito) XP_393785.3 Apis mellifera (honey bee) XP_001952854.1 Acyrthosiphon pisum (pea aphid) 120458 Branchiostoma floridae (lancelet) BGIBMGA012021-PA Bombyx mori (silk worm) ENSBTAP00000019489 Bos taurus (bovine) ENSCAFP00000012211 Canis familiaris (dog) JA01508 Caenorhabditis japonica (nematode) ENSCPOP00000011418 Cavia porcellus (guinea pig) 233159 Daphnia pulex (daphnia) ENSECAP00000020049 Equus caballus (horse) ENSGACP00000003157 Gymnopilus aculeatus (mushroom) ENSGALP00000025229 Gallus gallus (chicken) ENSP00000382394 Homo sapiens (human) ISCW017915-PA Ixodes scapularis (deer tick) 91252 Lottia gigantea (owl limpet) ENSMODP00000008393 Monodelphis domestica (gray opossum) ENSMMUP00000025513 Macaca mulatta (rhesus monkey) ENSMUSP00000026284 Mus musculus (house mouse) ENSOANP00000008073 Ornithorynchus anatinus (platypus) ENSORLP00000009865 Oryzias latipes (japanese killifish) ENSPPYP00000020962 Pongo pygmaeus (orangutan) ENSPTRP00000057710 Pan troglodytes (chimpanzee) ENSRNOP00000011641 Rattus norvegicus (norway rat) XP_001192612.1 Strongylocentrotus purpuratus (purple sea urchin) XP_969252.1 Tribolium castaneum (red flour beetle) ENSTNIP00000010947 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000000357 Takifugu rubripes (pufferfish Takifugu) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV31705 NV17422 LH22749 ISCW017916 ISCW017915 FBgn0232149 FBgn0215611 FBgn0206888 FBgn0195744 FBgn0181652 FBgn0181651 JGI_V11_30674 JGI_V11_233159 JGI_V11_35537 JGI_V11_40221 FBgn0073062 FBgn0155745 FBgn0136802 FBgn0131469 FBgn0108621 FBgn0096033 CPIJ018552 CPIJ006385 CPIJ006384 BGIBMGA012021 ACYPI002526 GB16706 AGAP000058 AAEL003558 AAEL002335 PB23462 PHUM190870 GLEAN_03891
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	25676 w*; P{GAL4}zfh2MS209/In(4)ciD, ciD panciD
Harvard	- P{XP}zfh2d09602 - PBac{WH}zfh2f05624 - PBac{PB}zfh2c02999a, PBac{PB}c02999b
Kyoto	125424 w1118; P{RS5}zfh25-HA-1838
VDRC	v13305 w1118; P{GD4506}v13305/TM3
Genomic Clones ( 2 )
	BACH57F14 BACR44L03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 104 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH11902
Other clones	IP22195
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH26340 SD09261
Other clones	28567 38481 39539 39716 64287 65789 66421 76189 78284 79415 80118 82176 101003 108544 118272 121326 122260 124287 147348 153348 153962 155797 163588 164845 164990 174424 214245.21 214257.19 214275.4 214309.15 214511.13 281783 CK01.10D.E9 CK01.30B.B2 CK01.32D.E3 CK01.41B.C1 CK01.71B.B2 CK01.127D.C12 CK01.128D.H10 EC051878 EC053951 EC054366 EC056074 EK050743 EK056637 EK098633 EK099763 EK136632 EK151619 EK153253 EK166163 EK176536 EK176563 EK189606 EK189964 EK206951 EK212140 EK212330 EK223728 EK235110 EK245545 EK246847 EK251461 EK257020 EK258529 EK267864 EK269423 EK270652 EK279306 EK288303 EK291508 EK307131 EP07703 EP11135 EP11234 EP11750 EP12416 EP19964 IP14419 IP14519 IP14619 IP14719 RP004084106 RP004102109 RP004193939 RP004204471 RP004210182 RP004233696 RP004235012 RP004248600 RP004260003 RP004400454 RP004420435 RP004450445 RP004460696 RP004471435 RP004528179 RP004528972 RP004550188 SD04877
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004607 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43795
Antibody Information
	polyclonal (Lai et al., 1991, Lundell and Hirsh, 1992)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: zfh2 CG1449 (Zhong, 1999.11)
Source for database merge of
Additional comments
Other Comments
	zfh2 is required for proximal wng development. (Whitworth and Russell, 2003) eg is necessary for the maintenance of en and zfh2 expression in the serotonin neurons. (Lundell and Hirsh, 1998) One of the homeodomain loci identified in a screen for genes encoding DNA binding proteins capable of binding to a consensus Engrailed binding site. (Kalionis and O'Farrell, 1993) Assayed in an analysis of chromosome 4 using pulsed field gel electrophoresis. (Locke and McDermid, 1993) Profile of zfh2 expression in the larval CNS shows intriguing overlap with Ddc expression in specific serotonin and dopamine neurons. The product of zfh2 binds to a protein binding site in the Ddc promoter. (Lundell and Hirsh, 1992) The product of zfh2 possesses three homeodomains and sixteen C2H2 zinc fingers. The novel arrangement of interspersed homeodomain and zinc-finger motifs in the primary sequences of the zfh1 and zfh2 gene products may signify an unusual mechanism of transcriptional regulation by these products. (Fortini et al., 1991) The expression pattern of zfh2 suggests that the protein may be involved in neurogenesis. (Lai et al., 1991)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079884 RefSeq (Proteins) • NP_524623 DDBJ / EMBL / GenBank • AAA29051 AAF59339 AAF59339.2 AAL28229 AAQ67630 AAQ67631 AAQ67632 AAQ67633 AAQ67634 AAQ67635 AAQ67636 AAQ67637 AAQ67638 AAQ67639 AAQ67640 AAQ67641 AAQ67642 AAQ67643 AAQ67644 AAQ67645 AAQ67646 AAQ67647 AAQ67648 AAQ67649 AAQ67650 AAQ67651 AAQ67652 AAQ67653 AC009535 AC010668 AC018478 AF242879 AF242880 AI134433 AW940433 AY060681 AY312816 AY312817 AY312818 AY312819 AY312820 AY312821 AY312822 AY312823 AY312824 AY312825 AY312826 AY312827 AY312828 AY312829 AY312830 AY312831 AY312832 AY312833 AY312834 AY312835 AY312836 AY312837 AY312838 AY312839 M63450 U87286 Entrez Gene - A searchable database of RefSeq genes. • 43795 UniProtKB/Swiss-Prot • P28167
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Homeobox, conserved site (IPR017970) Zinc finger, C2H2-type/integrase, DNA-binding (IPR013087) Zinc finger, C2H2-like (IPR015880) Homeobox (IPR001356) Zinc finger, C2H2 (IPR007087) Homeodomain-like (IPR009057) Homeodomain-related (IPR012287)
Linkouts
	BioGRID - A database of protein and genetic interactions • 68628 DroID - A comprehensive database of gene and protein interactions. • FBgn0004607 DRSC - Results from RNAi screens. • FBgn0004607 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004607 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1449-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004607 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43795 InParanoid A subset of ortholog calls from InParanoid. • AAEL002335-PA Aedes aegypti (mosquito) XP_393785.3 Apis mellifera (honey bee) XP_001952854.1 Acyrthosiphon pisum (pea aphid) 120458 Branchiostoma floridae (lancelet) BGIBMGA012021-PA Bombyx mori (silk worm) ENSBTAP00000019489 Bos taurus (bovine) ENSCAFP00000012211 Canis familiaris (dog) JA01508 Caenorhabditis japonica (nematode) ENSCPOP00000011418 Cavia porcellus (guinea pig) 233159 Daphnia pulex (daphnia) ENSECAP00000020049 Equus caballus (horse) ENSGACP00000003157 Gymnopilus aculeatus (mushroom) ENSGALP00000025229 Gallus gallus (chicken) ENSP00000382394 Homo sapiens (human) ISCW017915-PA Ixodes scapularis (deer tick) 91252 Lottia gigantea (owl limpet) ENSMODP00000008393 Monodelphis domestica (gray opossum) ENSMMUP00000025513 Macaca mulatta (rhesus monkey) ENSMUSP00000026284 Mus musculus (house mouse) ENSOANP00000008073 Ornithorynchus anatinus (platypus) ENSORLP00000009865 Oryzias latipes (japanese killifish) ENSPPYP00000020962 Pongo pygmaeus (orangutan) ENSPTRP00000057710 Pan troglodytes (chimpanzee) ENSRNOP00000011641 Rattus norvegicus (norway rat) XP_001192612.1 Strongylocentrotus purpuratus (purple sea urchin) XP_969252.1 Tribolium castaneum (red flour beetle) ENSTNIP00000010947 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000000357 Takifugu rubripes (pufferfish Takifugu) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/zcfhm21.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43795 modMine - Data generated by the modENCODE project. • FBgn0004607 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV31705 NV17422 LH22749 ISCW017916 ISCW017915 FBgn0232149 FBgn0215611 FBgn0206888 FBgn0195744 FBgn0181652 FBgn0181651 JGI_V11_30674 JGI_V11_233159 JGI_V11_35537 JGI_V11_40221 FBgn0073062 FBgn0155745 FBgn0136802 FBgn0131469 FBgn0108621 FBgn0096033 CPIJ018552 CPIJ006385 CPIJ006384 BGIBMGA012021 ACYPI002526 GB16706 AGAP000058 AAEL003558 AAEL002335 PB23462 PHUM190870 GLEAN_03891
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG1449 (Keleman et al., 2009.8.5) zfh2 (Riddle et al., 2008, Tran and Doe, 2007, Stark et al., 2005, Podemski et al., 2004, de Navascués and Modolell, 2007, Akdemir et al., 2007, Johansson et al., 2007, Terriente et al., 2008, Weake et al., 2011, Perea et al., 2009, Dichtel-Danjoy et al., 2009, Tran et al., 2010, Sun et al., 2004, Beltran et al., 2007) Zfh-2 (Mettler et al., 2006, Lundell et al., 2003, Isshiki et al., 2001, Karcavich and Doe, 2005, Benítez et al., 2009) zfh-2 (Sousa-Neves et al., 2005, Vogler and Urban, 2004, Baena-Lopez et al., 2003, Whitworth and Russell, 2003, Kramps et al., 2002, Podemski et al., 2001, Bowles et al., 2000, Leach et al., 2000, Locke et al., 2000, Whitworth and Russell, 2000, Locke et al., 1999, Locke et al., 1998, Lundell and Hirsh, 1998, Ahmed and Podemski, 1997, Lundell and Hirsh, 1993, Kalionis and O'Farrell, 1993, Hashimoto et al., 1992, Lai et al., 1991, Fortini et al., 1991, Guntur and Lundell, 2006, Guntur and Lundell, 2008, Dichtel-Danjoy et al., 2009) Zfh2 (Vogler and Urban, 2003, Nusinow et al., 2008, Tran and Doe, 2008, Spresser et al., 2008, Beckervordersandforth et al., 2008, Slawson et al., 2006) ZFH-2 (Lundell and Hirsh, 1994) ZFH2 (Kanai et al., 2005)
Name Synonym	Zinc finger homeodomain-2 (Guntur and Lundell, 2008) zinc finger homeodomain 2 (Perea et al., 2009, Terriente et al., 2008) Zn finger homeodomain 2
Secondary FlyBase IDs
References ( 84 )
Generate a list of	All references relating to this gene ( 84 )
List References by type	Research paper  ( 56 ) Supplementary material  ( 3 ) Review  ( 1 ) Personal communication to FlyBase  ( 3 ) Abstract  ( 9 ) FlyBase analysis  ( 2 ) Letter  ( 2 ) Curated genome annotation  ( 2 ) Protein sequence record  ( 1 ) DNA/RNA sequence record  ( 2 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 3 )
	Gabilondo et al., 2011, Mech. Dev. 128(3-4): 208--221 A targeted genetic screen identifies crucial players in the specification of the Drosophila abdominal Capaergic neurons. [FBrf0213290] Weake et al., 2011, Genes Dev. 25(14): 1499--1509 Post-transcription initiation function of the ubiquitous SAGA complex in tissue-specific gene activation. [FBrf0214372] Tran et al., 2010, Development 137(9): 1421--1430 Recombineering Hunchback identifies two conserved domains required to maintain neuroblast competence and specify early-born neuronal identity. [FBrf0210578] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...