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General Information
Symbol
Dmel\GluRIIA
Species
D. melanogaster
Name
Glutamate receptor IIA
Annotation Symbol
CG6992
Feature Type
FlyBase ID
FBgn0004620
Gene Model Status
Stock Availability
Gene Snapshot
Glutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. [Date last reviewed: 2018-09-06]
Also Known As

DGluRIIA, DGluR-II, DGluR-IIA, GluR, GluRII-A

Key Links
Genomic Location
Cytogenetic map
Sequence location
2L:5,555,072..5,558,994 [+]
Recombination map

2-17

RefSeq locus
NT_033779 REGION:5555072..5558994
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (21 terms)
Molecular Function (7 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN001826301
(assigned by GO_Central )
inferred from sequence or structural similarity
inferred from biological aspect of ancestor with PANTHER:PTN000437926
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000437926
(assigned by GO_Central )
Biological Process (9 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:KaiR1D; FB:FBgn0038837
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN001826301
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN001826301
(assigned by GO_Central )
Cellular Component (5 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from sequence or structural similarity with RGDID:2735
inferred from biological aspect of ancestor with PANTHER:PTN000437926
(assigned by GO_Central )
Protein Family (UniProt)
-
Summaries
Gene Group (FlyBase)
NON-NMDA IONOTROPIC GLUTAMATE RECEPTORS - GLURII NEUROMUSCULAR JUNCTION-SUBTYPE -
In Drosophila, neuromuscular junction type A and type B glutamate receptors are heterotetramers assembled from either GluRIIA or GluRIIB plus other GluRII subunits. In response to the neurotransmitter, glutamate, they conduct Ca2+. (Adapted from FBrf0228432).
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\GluRIIA for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0079106
3253
907
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0078739
104.4
907
6.06
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\GluRIIA using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

GluRIIA mRNA localizes to cytoplasmic puncta in muscles 6 and 7 and is not associated with the neuromuscular junction.

GluRIIA expression is first detected in late stage 12 embryos. The first expression is in a segmentally repeated pattern in abdominal segments 2-7. The pattern consists of one dorsal group and one ventral group of somatic mesodermal cells in each hemisegment. By mid stage 13, expression is also observed in a lateral group of cells. As development proceeds, the pattern becomes more extensive and complex and comprises cells of the developing dorsal, lateral, and ventral somatic muscles. Expression is apparent in the thoracic segments at stage 14. By stage 16, expression is strong in all somatic muscles and in pharyngeal muscle. Weaker expression is observed in visceral muscle. Expression in larval muscles was assayed to determine if staining is observed throughout the muscle fibers or only in the areas of innervation. Results indicate that expression occurs throughout the individual muscle fibers and not just at synaptic sites.

GluRIIA transcripts are observed in late embryos, 2nd and 3rd instar larvae, early and late pupae, and early adults. They are most prominent in late embryos at the same time that they are observed in the somatic musculature by in situ hybridization.

Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\GluRIIA in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 8 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 27 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of GluRIIA
Transgenic constructs containing regulatory region of GluRIIA
Deletions and Duplications ( 4 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (18)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
4 of 15
Yes
No
4 of 15
Yes
No
4 of 15
Yes
No
4 of 15
Yes
No
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
1  
3 of 15
No
No
2 of 15
No
No
1  
2 of 15
No
No
2  
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
Yes
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (17)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
4 of 15
Yes
No
4 of 15
Yes
No
4 of 15
Yes
No
4 of 15
Yes
No
3 of 15
No
No
3 of 15
No
Yes
3 of 15
No
No
3 of 15
No
No
2 of 15
No
No
2  
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
Yes
Rattus norvegicus (Norway rat) (17)
4 of 13
Yes
No
4 of 13
Yes
No
4 of 13
Yes
No
4 of 13
Yes
No
3 of 13
No
Yes
3 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
Yes
2 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (15)
4 of 12
Yes
No
3 of 12
No
Yes
3 of 12
No
Yes
3 of 12
No
No
3 of 12
No
Yes
2 of 12
No
No
2 of 12
No
No
2 of 12
No
No
2 of 12
No
No
2 of 12
No
No
2 of 12
No
No
2 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
Yes
Danio rerio (Zebrafish) (32)
4 of 15
Yes
No
4 of 15
Yes
No
4 of 15
Yes
No
4 of 15
Yes
No
3 of 15
No
Yes
3 of 15
No
Yes
3 of 15
No
Yes
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
Yes
2 of 15
No
Yes
2 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (15)
4 of 15
Yes
No
4 of 15
Yes
Yes
3 of 15
No
No
3 of 15
No
No
3 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (20)
2 of 9
Yes
No
2 of 9
Yes
No
2 of 9
Yes
No
2 of 9
Yes
No
2 of 9
Yes
No
2 of 9
Yes
No
2 of 9
Yes
No
2 of 9
Yes
No
2 of 9
Yes
No
2 of 9
Yes
No
2 of 9
Yes
No
2 of 9
Yes
No
2 of 9
Yes
No
2 of 9
Yes
No
2 of 9
Yes
No
2 of 9
Yes
No
2 of 9
Yes
No
2 of 9
Yes
No
2 of 9
Yes
No
2 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091901ZM )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500D3 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Mayetiola destructor
Hessian fly
Mayetiola destructor
Hessian fly
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01QX )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0764 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G02LN )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (43)
5 of 10
5 of 10
4 of 10
4 of 10
4 of 10
4 of 10
4 of 10
4 of 10
3 of 10
3 of 10
3 of 10
3 of 10
3 of 10
3 of 10
3 of 10
3 of 10
3 of 10
3 of 10
3 of 10
3 of 10
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    RNA-RNA
    Physical Interaction
    Assay
    References
    RNA-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2L
    Recombination map

    2-17

    Cytogenetic map
    Sequence location
    2L:5,555,072..5,558,994 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    25E6-25E6
    Limits computationally determined from genome sequence between P{lacW}Hel25Ek11511 and P{lacW}l(2)k06502k06502
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    25F-25F
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Location
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (16)
    Genomic Clones (6)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (49)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       
      Commercially Available Antibodies
       
      Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
      Other Information
      Relationship to Other Genes
      Source for database identify of

      Source for identity of: GluRIIA CG6992

      Source for database merge of
      Additional comments
      Other Comments

      GluRIIC is required for synaptic localisation of GluRIIA and GluRIIB proteins. Either GluRIIA or GluRIIB, but not both, is required for synaptic localisation of GluRIIC protein. GluRIIA and GluRIIB proteins compete with each other for access to GluRIIC protein and subsequent localisation to the synapse.

      Study of mutants reveals that a decrease in postsynaptic receptors leads to an increase in presynaptic transmitter release, indicating that postsynaptic activity controls a retrograde signal that regulates presynaptic function.

      Developmental changes of GluRIIA distribution in wild-type embryos are characterised. GluRIIA receptors are found clustered in the non-nerve-contacted areas at the beginning of synaptogenesis. As synapse formation proceeds these clusters disperse and are found at the neuromuscular junction. By rearing parats1 embryos, at restrictive temperatures, starting at different times during synaptogenesis, it is found that neural activity at a certain period of development profoundly affects the distribution of GluRIIA receptors.

      Temporal and spatial expression patterns during embryogenesis and in larval muscle are determined.

      Glutamate receptor channels in Drosophila embryos and larvae have been studied using the patch-clamp technique.

      Receptor localization can be determined by application of L-glutamate and monitering with patch clamping techniques.

      In aneural pros mutants functional glutamate receptors are expressed at normal time and distribution over the muscle surface but subsequently fail to cluster to the neuromuscular junction as they would in wild type. The second phase of glutamate receptor synthesis characteristic of wild type fails to occur. The few pros mutants where innervation occurs, but is delayed, show late clustering and late second phase synthesis of glutamate receptors, indicating that these events are innervation-dependent. Likewise, if the neuromuscular junction occurs at an aberrant site, so does the glutamate receptor cluster.

      GluRIIA expression in the postsynaptic membrane is reduced by changes in presynaptic electrical activity. Presynaptic electrical activity during embryonic synaptogenesis is constitutively required for GluRIIA expression at the NMJ and to induce receptor clustering at the NMJ.

      GluRIIA has been cloned and sequenced.

      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 43 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      FlyMine - An integrated database for Drosophila genomics
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (genetic) - An integrated Molecular Interaction Database
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Synonyms and Secondary IDs (34)
      Reported As
      Symbol Synonym
      DmelGluRIIA
      Glu-RII
      GluRIIA
      (Basargekar et al., 2020, Han et al., 2020, Kondo et al., 2020, Lecompte et al., 2020, Wang et al., 2020, Yu et al., 2020, Berke et al., 2019, Böhme et al., 2019, Chen et al., 2019, Goel et al., 2019, Gratz et al., 2019, Hall et al., 2019, Harbison et al., 2019, Kamimura et al., 2019, Patrón et al., 2019, Rao and Deng, 2019.10.23, Tegeder et al., 2019, Akbergenova et al., 2018, Harris et al., 2018, Hauswirth et al., 2018, Koon et al., 2018, Wentzel et al., 2018, Xing et al., 2018, Chen et al., 2017, Genç et al., 2017, Kiragasi et al., 2017, Mallik et al., 2017, Newman et al., 2017, Orr et al., 2017, Orr et al., 2017, Perry et al., 2017, Transgenic RNAi Project members, 2017-, Van Vactor and Sigrist, 2017, Wang et al., 2017, Yeates et al., 2017, Zhang et al., 2017, Zhang et al., 2017, Crocker et al., 2016, Harris et al., 2016, Lee and Schwarz, 2016, Penney et al., 2016, Sarov et al., 2016, Spring et al., 2016, Sturgeon et al., 2016, Ziegler et al., 2016, Brusich et al., 2015, Davis and Müller, 2015, Deivasigamani et al., 2015, Gaviño et al., 2015, Harris et al., 2015, Hu et al., 2015, Kim et al., 2015, Koles et al., 2015, Muhammad et al., 2015, Ramos et al., 2015, Romano et al., 2015, Gardiol and St Johnston, 2014, Ghosh et al., 2014, Kerr et al., 2014, Machamer et al., 2014, Morel et al., 2014, Petzoldt et al., 2014, Romano et al., 2014, Sulkowski et al., 2014, Wang et al., 2014, Xing et al., 2014, Castellanos et al., 2013, Lee et al., 2013, Lee et al., 2013, Maldonado et al., 2013, Shi et al., 2013, Younger et al., 2013, Catalán et al., 2012, Chen et al., 2012, Chorna and Hasan, 2012, Dickman et al., 2012, Fuentes-Medel et al., 2012, Fukui et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Jordán-Álvarez et al., 2012, Kim et al., 2012, Müller and Davis, 2012, Owald et al., 2012, Owald et al., 2012, Timmerman and Sanyal, 2012, Tsai et al., 2012, Tsubouchi et al., 2012, Cheng et al., 2011, Ganesan et al., 2011, Liu et al., 2011, Miśkiewicz et al., 2011, Müller et al., 2011, Pilgram et al., 2011, Sun et al., 2011, Weyhersmüller et al., 2011, Chen et al., 2010, Croset et al., 2010, Higashi-Kovtun et al., 2010, Long et al., 2010, Marie et al., 2010, Morimoto et al., 2010, Nahm et al., 2010, Tsurudome et al., 2010, Wang et al., 2010, Benton et al., 2009, Chen et al., 2009, Dickman and Davis, 2009, Frank et al., 2009, Karr et al., 2009, Kumar et al., 2009, Kurshan et al., 2009, Lee et al., 2009, Lin et al., 2009, Menon et al., 2009, Ramachandran et al., 2009, Ren et al., 2009, Ataman et al., 2008, Bogdanik et al., 2008, Chai et al., 2008, Chang et al., 2008, Liebl et al., 2008, Romero et al., 2008, Schmid et al., 2008, Augustin et al., 2007, Haas et al., 2007, Heckscher et al., 2007, Kazama et al., 2007, Kohsaka et al., 2007, Li et al., 2007, Nair et al., 2007, Pack-Chung et al., 2007, Pan and Broadie, 2007, Rohrbough et al., 2007, Zeitlinger et al., 2007, Zhang et al., 2007, Ataman et al., 2006, Dudu et al., 2006, Frank et al., 2006, Kittel et al., 2006, Kittel et al., 2006, Sandmann et al., 2006, Schmid et al., 2006, Chen and Featherstone, 2005, Chen et al., 2005, Liebl and Featherstone, 2005, Rasse et al., 2005, Rohrbough et al., 2004, Kazama et al., 2003, Renden and Broadie, 2003)
      Name Synonyms
      Glutamate receptor IIA
      glutamate IIA receptor
      glutamate receptor
      glutamate receptor IIA
      glutamate receptor subunit IIA
      Secondary FlyBase IDs
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (282)