Gβe, Gbe, Gβe, Gβ
Gene model reviewed during 5.45
There is only one protein coding transcript and one polypeptide associated with this gene
346 (aa); 39 (kD observed)
G proteins are composed of 3 units, alpha, beta and gamma.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gβ76C using the Feature Mapper tool.
Gβ76C protein is localized to the photoreceptor cells of the retina. It is also detected in the lamina and the medulla, presumably in axons of the photoreceptor cells that project to these optic ganglia.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Gβ76C in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Gβ76C is an eye specific G-protein β subunit which is essential for G-protein-receptor coupling in vivo. Mutants are also severely defective in the deactivation of the light response demonstrating an essential role for the Gβ76C subunit in terminating the active state of the signalling cascade.
An in situ 35S-labelled guanosine 5'-3-0-(thio)triphosphate (35S GTPγS) binding procedure can assay light stimulated G protein activity in eyes. Results demonstrate Gβ76C functions as the β subunit of a heterotrimeric G protein that couples photoactivation of rhodopsin to downstream components in the phototransduction cascade.