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Gene Dmel\CaMKII

General Information
Symbol	Dmel\CaMKII	Species	D. melanogaster
Name	Calcium/calmodulin-dependent protein kinase II	Annotation symbol	CG18069
Feature type	protein_coding_gene	FlyBase ID	FBgn0004624
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	calcium/calmodulin-dependent protein kinase II, Ca2+/calmodulin-dependent protein kinase II, dCaMKII, CaM KII, CaMK II, CaM
Genomic Location
Chromosome (arm)	4	Recombination map
Cytogenetic map	102F6-102F7	Sequence location	4:1,056,643..1,074,329 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Calcium/calmodulin-dependent protein kinase II is referred to in FlyBase by the symbol Dmel\CaMKII (CG18069, FBgn0004624). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein serine/threonine kinase activity; calmodulin-dependent protein kinase activity. There is experimental evidence that it is involved in the biological process: synaptic transmission; learning or memory; regulation of filopodium assembly; long-term memory; regulation of ovulation; male courtship behavior. 18 alleles are reported. The phenotypes of these alleles are annotated with: bouton; adult abdomen; neuromuscular junction; motor neuron; embryonic/larval neuromuscular junction; wing; synapse; axon. It has 9 annotated transcripts and 9 annotated polypeptides. Protein features are: Calcium/calmodulin-dependent protein kinase II, association-domain; Calcium/calmodulin-dependent/calcium-dependent protein kinase; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase, catalytic domain; Serine/threonine-protein kinase-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 12-24 hour embryonic stages, during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult thoracico-abdominal ganglion. Comments on Affy2 ProbeSet: ProbeSet 1640534_s_at completely aligns to an exonic region of only a subset of 7 of the 9 FlyBase-annotated transcript isoforms of CaMKII. Gene sequence location is 4:1056643..1074329.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Controlled Vocabulary Terms regulation of ovulation
FB2012_01	Sequence features BKN50918 HFA17214 BKN50783 BKN27335 Controlled Vocabulary Terms embryonic/larval hypodermal muscle A1-7 ventral longitudinal muscle 4 intense terminal button postsynaptic density A1-7 ventral longitudinal muscle 3 A1-7 ventral longitudinal muscle 1 embryonic stage 17(iv) axon faint motor neuron A1-7 ventral longitudinal muscle 2 embryonic stage 17(i) References Yang et al., 2010, EMBO J. 29(18): 3196--3207
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 102F6-102F7
Experimentally Determined Cytological Location
Cytogenetic map Notes References 102E-102F   (determined by in situ hybridisation)   (Cho et al., 1991)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CaMKII for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CaMKII-RA FBtr0089218  NM_166810   2844   490 CaMKII-RB FBtr0089219  NM_166811   2947   509 CaMKII-RC FBtr0089217  NM_079896   3024   490 CaMKII-RD FBtr0100146  NM_166812   3150   530 CaMKII-RE FBtr0100147  NM_166813   3087   509 CaMKII-RG FBtr0100148  NM_001014696   3108   516 CaMKII-RH FBtr0300377  NM_001169360   2310   490 CaMKII-RI FBtr0300378  NM_001169361   3036   530 CaMKII-RJ FBtr0300379  NM_001169362   1835   531
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CaMKII-PA   FBpp0088282   55.5   490   7.48     NP_726633   AAF59388 CaMKII-PB   FBpp0088283   57.6   509   7.34     NP_726634   AAF59390 CaMKII-PC   FBpp0088281   55.5   490   7.48     NP_524635   AAF59389 CaMKII-PD   FBpp0099496   59.9   530   7.46     NP_726635   AAN06568 CaMKII-PE   FBpp0099497   57.6   509   7.34     NP_726636   AAN06569 CaMKII-PG   FBpp0099498   58.4   516   7.48     NP_001014696   AAX53595 CaMKII-PH   FBpp0289606   55.5   490   7.48     NP_001162831   ACZ95100 CaMKII-PI   FBpp0289607   59.9   530   7.46     NP_001162832   ACZ95101 CaMKII-PJ   FBpp0289608   60.0   531   7.46     NP_001162833   ACZ95102
Additional Polypeptide Data & Comments
Reported size (kDa)	530, 516, 509, 490 (aa); 60, 58, 55 (kD) (Ohsako et al., 1993) 490 (aa); 55 (kD) (Cho et al., 1991)
Comments	There are four forms of CaMKII kinase which differ by insertions or deletions near the carboxy terminus of the putative link segment which is thought to join the amino- and carboxy-terminal globules. They were purified from transfected mammalian cells and Drosophila head extracts and their catalytic properties described. Catalytic activity is dependent on Ca2+ and calmodulin before autophosphorylation. Ca2+-independent activity is observed after autophosphorylation. (Ohsako et al., 1993) There are four forms of CaMKII kinase which differ by insertions or deletions near the carboxy terminus of the putative link segment which is thought to join the amino and carboxy-terminal globules. They were purified from transfected mammalian cells and Drosophila head extracts and their catalytic properties described. Catalytic activity is dependent on Ca2+ and calmodulin before autophosphorylation. Ca2+-independent activity is observed after autophosphorylation. (Ohsako et al., 1993, Ohsako et al., 1993) There are four forms of CaMKII kinase which differ by insertions or deletions near the carboxy terminus of the putative link segment which is thought to join the amino and carboxy-terminal globules. They were purified from transfected mammalian cells and Drosophila head extracts and their catalytic properties described. Catalytic activity is dependent on Ca2+ and calmodulin before autophosphorylation. Ca2+-independent activity is observed after autophosphorylation. The 516aa isoform is a minor form in adult heads. (Ohsako et al., 1993) One of several products generated by alternative splicing. (FlyBase, 1992-, FlyBase, 1992-, FlyBase, 1992-, FlyBase, 1992-) CaMKII protein purified 200-fold from adult Drosophila heads was shown to have kinase activity and to aquire Ca2+-independent activity after autophosphorylaton. CaMKII protein expressed from a Drosophila cDNA in COS cells was shown to have the same properties. Four autophosphorylation sites are conserved between the rat and the Drosophila enzymes. (Cho et al., 1991)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Calcium/calmodulin-dependent/calcium-dependent protein kinase (IPR020636) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442) Calcium/calmodulin-dependent protein kinase II, association-domain (IPR013543)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202570   AA202590   AA390873   AA392839   AA440742   AA540677   AA695708   AA695931   AA697269   AA951116   AA951609   AE014135 AAF59388   AE014135 AAF59389   AE014135 AAF59390   AE014135 AAN06568   AE014135 AAN06569   AE014135 AAX53595   AC010838   AE014135 ACZ95100   AE014135 ACZ95101   AE014135 ACZ95102   AI512033   AW943083   BG632097   BG633636   BI162226   BI162862   BI165294   BI167773   BI168838   BI169747   BI172571   BI172592   BI213223   BI213894   BI213915   BI214991   BI230559   BI231345   BI235240   BI235263   BI235388   BI238253   BI239900   BI356474   BI362865   BI364288   BI365874   BI367040   BI367831   BI368312   BI372023   BI372453   BI373463   BI374073   BI374744   BI375428   BI482212   BI483083   BI484366   BI484876   BI485692   BI486134   BI486150   BI486156   BI486785   BI574533   BI577405   BI579677   BP548805   BP548806   BT021958   BT029114   BT050453   CA806289   CA807506   CK445222   CO177336   CO177417   CO178523   CO178735   CO179163   CO179248   CO182474   CO185814   CO188675   CO188687   CO189142   CO190660   CO196367   CO196500   CO262168   CO262781   CO263509   CO263869   CO264048   CO264102   CO264114   CO264129   CO264401   CO265551   CO266486   CO266494   CO266514   CO266639   CO267948   CO268695   CO269860   CO270810   CO271155   CO272253   CO273930   CO274153   CO274584   CO274763   CO274936   CO275124   CO275187   CO275219   CO275416   CO275658   CO276047   CO277979   CO278132   CO278212   CO278596   CO278698   CO278891   CO278948   CO278991   CO279748   CO279892   CO280790   CO281214   CO281507   CO282225   CO282344   CO283674   CO284003   CO284206   CO284543   CO285849   CO287036   CO287718   CO289101   CO289111   CO289315   CO290067   CO290445   CO290464   CO290837   CO290901   CO291236   CO291771   CO292035   CO292107   CO292349   CO292445   CO294033   CO294422   CO294439   CO294496   CO295196   CO295745   CO297213   CO297446   CO297703   CO297734   CO298682   CO298704   CO299924   CO300927   CO301266   CO301328   CO302127   CO302614   CO303414   CO303705   CO304202   CO304683   CO304878   CO305114   CO305370   CO305513   CO305798   CO306206   CO307095   CO307511   CO308112   CO308187   CO308257   CO309887   CO310216   CO310507   CO310673   CO310870   CO312801   CO314476   CO314599   CO314649   CO314733   CO314765   CO315087   CO315419   CO315687   CO316343   CO316365   CO318428   CO318550   CO319409   CO320788   CO321294   CO321899   CO322319   CO322425   CO323254   CO324660   CO324784   CO326692   CO328315   CO328394   CO328405   CO328432   CO328883   CO328951   CO329009   CO329119   CO329384   CO330039   CO330253   CO330328   CO330404   CO331082   CO331432   CO332603   CO332639   CO339026   CO339060   CO339506   CO339706   CO339879   CO340528   CO340656   CO340703   CO340954   CO341344   CO341933   CO342000   CO342006   CO342060   CO342119   CO343228   CO343390   CO344408   CO345070   D13330 BAA02593   D13331 BAA02594   D13332 BAA02595   D13333 BAA02596   DN154264   EC052847   EC053068   EC053544   EC057468   EC057827   EC058380   EC059479   EC059592   EC060786   EC060836   EC061483   EC061611   EC062448   EC062671   EC063544   EC064468   EC064549   EC065455   EC065965   EC067149   EC067625   EC067667   EC068271   EC068561   EC068578   EC069284   EC069687   EC070213   EC070219   EC070302   EC070370   EC072664   EC072783   EC073042   EC074011   EC074224   EC074327   EC074533   EC074818   EC075838   EC076745   EC077145   EC078352   EC078947   EC079077   EC079271   EC080517   EC081449   EC083756   EC084015   EC084365   EC084836   EC084969   EC085764   EC086331   EC086813   EC086873   EC088297   EC088337   EC088365   EC089255   EC089881   EC089882   EC090128   EC195112   EC196485   EC196631   EC197083   EC197575   EC198081   EC198549   EC199034   EC199165   EC199424   EC199883   EC200017   EC200553   EC201071   EC201459   EC201961   EC202099   EC202516   EC204911   EC204922   EC207243   EC207896   EC207990   EC208873   EC209473   EC209668   EC209687   EC209735   EC209761   EC210131   EC210132   EC210417   EC210720   EC210915   EC212609   EC212681   EC212891   EC213300   EC217498   EC218523   EC218529   EC218725   EC218774   EC218800   EC219464   EC220182   EC221468   EC221736   EC222167   EC222563   EC223434   EC223704   EC225126   EC225137   EC225183   EC226051   EC226400   EC226472   EC226557   EC227279   EC227766   EC228127   EC228602   EC229055   EC229289   EC229734   EC230311   EC230825   EC231634   EC232708   EC233217   EC235893   EC235922   EC235928   EC237281   EC237745   EC237981   EC238181   EC238278   EC238341   EC238475   EC238806   EC239773   EC242124   EC243230   EC243481   EC243666   EC244026   EC244833   EC245152   EC245873   EC246607   EC246923   EC246978   EC248695   EC248744   EC248962   EC249104   EC249156   EC249229   EC249533   EC249830   EC250487   EC250740   EC251535   EC251631   EC251964   EC252225   EC252400   EC252902   EC252927   EC253387   EC253510   EC253760   EC255271   EC255459   EC256630   EC256683   EC257104   EC258070   EC258323   EC258666   EC258939   EC259063   EC259253   EC259274   EC259296   EC259420   EC260340   EL875349   EL875350   EL884076   EL884077   EL884194   EL884195   ES689215   ES689225   EV577037   EV597023   EV598592   GH941573   GH943560   GH943874   GH945222   GH945415   GH946973   GH948516   GH949489   GH950687   GH951682   GH951838   GH952969   GH953384   GH953459   GH953640   GH953746   GH954354   GH954511   GH955433   GH956301   GH958786   GH961314   GH963532   GH965908   GH968304   GH968431   GH968748   GH969139   GH969194   GH971143   GH972194   GH973703   GH974589   GH974735   GH975743   GH976076   GH976170   GH976688   GH977388   GH981307   GH981694   GH982801   HQ384015   M74583 AAA51459   S65712 AAB28244   S65716 AAB28245   S65717 AAB28246   S65719 AAB28247   S65724 AAB28248   U22420 AAA64214
UniProtKB/Swiss-Prot	Q00168
UniProtKB/TrEMBL	Q24045 A4V133 A4V134 D1YSG7 D1YSG8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 5 -- 7   organism | uniform   (Rachidi et al., 1999) embryonic stage 8 -- 11   germ band   (Rachidi et al., 1999) embryonic stage 8 -- 12   posterior midgut primordium   (Rachidi et al., 1999) anterior midgut primordium   (Rachidi et al., 1999) embryonic stage 10 -- 14   embryonic neuroblast   (Rachidi et al., 1999) embryonic stage 13   midgut primordium   (Rachidi et al., 1999) embryonic stage 14 -- 17   embryonic/larval central nervous system   (Rachidi et al., 1999) antenno-maxillary complex   (Rachidi et al., 1999) first instar larval stage   embryonic/larval central nervous system | uniform   (Rachidi et al., 1999) second instar larval stage -- third instar larval stage   thoracic segment of ventral nerve cord   (Rachidi et al., 1999) embryonic/larval brain   (Rachidi et al., 1999) prepupal stage P1   embryonic/larval brain   (Rachidi et al., 1999) eye disc   (Rachidi et al., 1999) pupal stage   optic lobe   (Rachidi et al., 1999) supraesophageal ganglion   (Rachidi et al., 1999) adult stage   retina   (Rachidi et al., 1999) Kenyon cell   (Rachidi et al., 1999) optic lobe neuron   (Rachidi et al., 1999) neuron of fan-shaped body   (Rachidi et al., 1999) neuron of ellipsoid body   (Rachidi et al., 1999)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference adult stage   adult head   (Cho et al., 1991) immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 16   embryonic/larval hypodermal muscle | faint & uniform   (Kazama et al., 2003) Comment:14 hr AEL embryonic stage 17   embryonic/larval hypodermal muscle | faint   (Kazama et al., 2003) Comment:17-22 hr AEL A1-7 ventral longitudinal muscle 1 | faint   (Kazama et al., 2003) Comment:17-22 hr AEL A1-7 ventral longitudinal muscle 2 | faint   (Kazama et al., 2003) Comment:17-22 hr AEL A1-7 ventral longitudinal muscle 3 | faint   (Kazama et al., 2003) Comment:17-22 hr AEL A1-7 ventral longitudinal muscle 4 | faint   (Kazama et al., 2003) Comment:17-22 hr AEL embryonic stage 17(i)   motor neuron   • terminal button (Kazama et al., 2003) Comment:17 hr AEL motor neuron   • axon (Kazama et al., 2003) Comment:17 hr AEL embryonic stage 17(iv)   motor neuron   • terminal button | intense (Kazama et al., 2003) Comment:22 hr AEL A1-7 ventral longitudinal muscle 1   • postsynaptic density | intense (Kazama et al., 2003) Comment:22 hr AEL A1-7 ventral longitudinal muscle 2   • postsynaptic density | intense (Kazama et al., 2003) Comment:22 hr AEL A1-7 ventral longitudinal muscle 3   • postsynaptic density | intense (Kazama et al., 2003) Comment:22 hr AEL A1-7 ventral longitudinal muscle 4   • postsynaptic density | intense (Kazama et al., 2003) Comment:22 hr AEL mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011) western blot Stage Tissue/Position (including subcellular localization) Reference adult stage   adult head   (Ohsako et al., 1993)
Additional Descriptive Data
	CaMkII protein is expressed uniformly in body wall muscles at 14 hrs AEL. By 22 hrs AEL, CaMKII can be faintly detected in the axons and terminal buttons of motor neurons innervating the A1-7 ventral longitudinal muscles 1-4 (muscles 6, 7, 12 and 13). By 22 hrs AEL, CaMKII immunoreactivity intensely labels the motor neuron terminal buttons, and the corresponding postsynaptic densities. (Kazama et al., 2003) CaMKII protein is expressed at much greater levels in adult head than body. (Cho et al., 1991)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0004624    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0004624 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 12-24 hour embryonic stages, during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0004624 expression level Developmental Stage   Expression Level embryo 00-02hr    1224 embryo 02-04hr    1194 embryo 04-06hr    1067 embryo 06-08hr    1236 embryo 08-10hr    1971 embryo 10-12hr    1847 embryo 12-14hr    3243 embryo 14-16hr    1577 embryo 16-18hr    4458 embryo 18-20hr    2973 embryo 20-22hr    3110 embryo 22-24hr    5195 larva L1    2043 larva L2    1718 larva L3 12hr old    1148 larva L3 puffstage 1-2    1184 larva L3 puffstage 3-6    1581 larva L3 puffstage 7-9    2156 white prepupae new    1909 white prepupae 12hr    2694 white prepupae 24hr    2617 pupae 2d postWPP    3631 pupae 3d postWPP    4346 pupae 4d postWPP    1342 adult male 01day    1696 adult male 05day    1221 adult male 30day    672 adult female 01day    854 adult female 05day    1583 adult female 30day    1185 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1224) embryo 02-04hr  (1194) embryo 04-06hr  (1067) embryo 06-08hr  (1236) embryo 08-10hr  (1971) embryo 10-12hr  (1847) embryo 12-14hr  (3243) embryo 14-16hr  (1577) embryo 16-18hr  (4458) embryo 18-20hr  (2973) embryo 20-22hr  (3110) embryo 22-24hr  (5195) larva L1  (2043) larva L2  (1718) larva L3 12hr old  (1148) larva L3 puffstage 1-2  (1184) larva L3 puffstage 3-6  (1581) larva L3 puffstage 7-9  (2156) white prepupae new  (1909) white prepupae 12hr  (2694) white prepupae 24hr  (2617) pupae 2d postWPP  (3631) pupae 3d postWPP  (4346) pupae 4d postWPP  (1342) adult male 01day  (1696) adult male 05day  (1221) adult male 30day  (672) adult female 01day  (854) adult female 05day  (1583) adult female 30day  (1185) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1224 embryo 02-04hr    1194 embryo 04-06hr    1067 embryo 06-08hr    1236 embryo 08-10hr  (1971) embryo 10-12hr  (1847) embryo 12-14hr  (3243) embryo 14-16hr  (1577) embryo 16-18hr  (4458) embryo 18-20hr  (2973) embryo 20-22hr  (3110) embryo 22-24hr  (5195) larva L1  (2043) larva L2  (1718) larva L3 12hr old    1148 larva L3 puffstage 1-2    1184 larva L3 puffstage 3-6  (1581) larva L3 puffstage 7-9  (2156) white prepupae new  (1909) white prepupae 12hr  (2694) white prepupae 24hr  (2617) pupae 2d postWPP  (3631) pupae 3d postWPP  (4346) pupae 4d postWPP    1342 adult male 01day  (1696) adult male 05day    1221 adult male 30day    672 adult female 01day    854 adult female 05day  (1583) adult female 30day    1185 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1224 embryo 02-04hr    1194 embryo 04-06hr    1067 embryo 06-08hr    1236 embryo 08-10hr    1971 embryo 10-12hr    1847 embryo 12-14hr    3243 embryo 14-16hr    1577 embryo 16-18hr    4458 embryo 18-20hr    2973 embryo 20-22hr    3110 embryo 22-24hr    5195 larva L1    2043 larva L2    1718 larva L3 12hr old    1148 larva L3 puffstage 1-2    1184 larva L3 puffstage 3-6    1581 larva L3 puffstage 7-9    2156 white prepupae new    1909 white prepupae 12hr    2694 white prepupae 24hr    2617 pupae 2d postWPP    3631 pupae 3d postWPP    4346 pupae 4d postWPP    1342 adult male 01day    1696 adult male 05day    1221 adult male 30day    672 adult female 01day    854 adult female 05day    1583 adult female 30day    1185 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1224 embryo 02-04hr    1194 embryo 04-06hr    1067 embryo 06-08hr    1236 embryo 08-10hr    1971 embryo 10-12hr    1847 embryo 12-14hr    3243 embryo 14-16hr    1577 embryo 16-18hr    4458 embryo 18-20hr    2973 embryo 20-22hr    3110 embryo 22-24hr    5195 larva L1    2043 larva L2    1718 larva L3 12hr old    1148 larva L3 puffstage 1-2    1184 larva L3 puffstage 3-6    1581 larva L3 puffstage 7-9    2156 white prepupae new    1909 white prepupae 12hr    2694 white prepupae 24hr    2617 pupae 2d postWPP    3631 pupae 3d postWPP    4346 pupae 4d postWPP    1342 adult male 01day    1696 adult male 05day    1221 adult male 30day    672 adult female 01day    854 adult female 05day    1583 adult female 30day    1185 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0004624 expression level Developmental Stage   Expression Level embryo 00-02hr    1224 embryo 02-04hr    1194 embryo 04-06hr    1067 embryo 06-08hr    1236 embryo 08-10hr    1971 embryo 10-12hr    1847 embryo 12-14hr    3243 embryo 14-16hr    1577 embryo 16-18hr    4458 embryo 18-20hr    2973 embryo 20-22hr    3110 embryo 22-24hr    5195 larva L1    2043 larva L2    1718 larva L3 12hr old    1148 larva L3 puffstage 1-2    1184 larva L3 puffstage 3-6    1581 larva L3 puffstage 7-9    2156 white prepupae new    1909 white prepupae 12hr    2694 white prepupae 24hr    2617 pupae 2d postWPP    3631 pupae 3d postWPP    4346 pupae 4d postWPP    1342 adult male 01day    1696 adult male 05day    1221 adult male 30day    672 adult female 01day    854 adult female 05day    1583 adult female 30day    1185 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1224) embryo 02-04hr  (1194) embryo 04-06hr  (1067) embryo 06-08hr  (1236) embryo 08-10hr  (1971) embryo 10-12hr  (1847) embryo 12-14hr  (3243) embryo 14-16hr  (1577) embryo 16-18hr  (4458) embryo 18-20hr  (2973) embryo 20-22hr  (3110) embryo 22-24hr  (5195) larva L1  (2043) larva L2  (1718) larva L3 12hr old  (1148) larva L3 puffstage 1-2  (1184) larva L3 puffstage 3-6  (1581) larva L3 puffstage 7-9  (2156) white prepupae new  (1909) white prepupae 12hr  (2694) white prepupae 24hr  (2617) pupae 2d postWPP  (3631) pupae 3d postWPP  (4346) pupae 4d postWPP  (1342) adult male 01day  (1696) adult male 05day  (1221) adult male 30day  (672) adult female 01day  (854) adult female 05day  (1583) adult female 30day  (1185) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1224 embryo 02-04hr    1194 embryo 04-06hr    1067 embryo 06-08hr    1236 embryo 08-10hr  1971 embryo 10-12hr  1847 embryo 12-14hr  (3243) embryo 14-16hr  1577 embryo 16-18hr  (4458) embryo 18-20hr  (2973) embryo 20-22hr  (3110) embryo 22-24hr  (5195) larva L1  2043 larva L2  1718 larva L3 12hr old    1148 larva L3 puffstage 1-2    1184 larva L3 puffstage 3-6  1581 larva L3 puffstage 7-9  2156 white prepupae new  1909 white prepupae 12hr  (2694) white prepupae 24hr  (2617) pupae 2d postWPP  (3631) pupae 3d postWPP  (4346) pupae 4d postWPP    1342 adult male 01day  1696 adult male 05day    1221 adult male 30day    672 adult female 01day    854 adult female 05day  1583 adult female 30day    1185 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1224 embryo 02-04hr    1194 embryo 04-06hr    1067 embryo 06-08hr    1236 embryo 08-10hr    1971 embryo 10-12hr    1847 embryo 12-14hr    3243 embryo 14-16hr    1577 embryo 16-18hr    4458 embryo 18-20hr    2973 embryo 20-22hr    3110 embryo 22-24hr    5195 larva L1    2043 larva L2    1718 larva L3 12hr old    1148 larva L3 puffstage 1-2    1184 larva L3 puffstage 3-6    1581 larva L3 puffstage 7-9    2156 white prepupae new    1909 white prepupae 12hr    2694 white prepupae 24hr    2617 pupae 2d postWPP    3631 pupae 3d postWPP    4346 pupae 4d postWPP    1342 adult male 01day    1696 adult male 05day    1221 adult male 30day    672 adult female 01day    854 adult female 05day    1583 adult female 30day    1185 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1224 embryo 02-04hr    1194 embryo 04-06hr    1067 embryo 06-08hr    1236 embryo 08-10hr    1971 embryo 10-12hr    1847 embryo 12-14hr    3243 embryo 14-16hr    1577 embryo 16-18hr    4458 embryo 18-20hr    2973 embryo 20-22hr    3110 embryo 22-24hr    5195 larva L1    2043 larva L2    1718 larva L3 12hr old    1148 larva L3 puffstage 1-2    1184 larva L3 puffstage 3-6    1581 larva L3 puffstage 7-9    2156 white prepupae new    1909 white prepupae 12hr    2694 white prepupae 24hr    2617 pupae 2d postWPP    3631 pupae 3d postWPP    4346 pupae 4d postWPP    1342 adult male 01day    1696 adult male 05day    1221 adult male 30day    672 adult female 01day    854 adult female 05day    1583 adult female 30day    1185 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0004624    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0004624 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult thoracico-abdominal ganglion. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0004624 expression level Tissue   Expression Level Larval Central Nervous System    505.3 Larval Midgut no informative data Larval Hindgut    34.3 Larval Malpighian Tubules    6.4 Larval Fat Body    21.5 Larval Salivary Gland    19.5 Larval Trachea    9.7 Larval Carcass    69.675 Adult Head    171.8 Adult Eye    20.825 Adult Brain    586.7 Adult Thoracic-Abdominal Ganglion    422.9 Adult Crop    76.1 Adult Midgut    14.5 Adult Hindgut    40.5 Adult Malpighian Tubules    5.1 Adult Fat Body    19.4 Adult Salivary Gland no informative data Adult Heart    14.15 Adult VirginFemale Spermatheca    8.2 Adult InseminatedFemale Spermatheca    15.3 Adult Ovary    9.3 Adult Testis    7.6 Adult Male Accessory Gland    30.7 Adult Carcass    38.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  505.3 Larval Midgut no informative data Larval Hindgut    34.3 Larval Malpighian Tubules    6.4 Larval Fat Body    21.5 Larval Salivary Gland    19.5 Larval Trachea    9.7 Larval Carcass    69.675 Adult Head    171.8 Adult Eye    20.825 Adult Brain  (586.7) Adult Thoracic-Abdominal Ganglion    422.9 Adult Crop    76.1 Adult Midgut    14.5 Adult Hindgut    40.5 Adult Malpighian Tubules    5.1 Adult Fat Body    19.4 Adult Salivary Gland no informative data Adult Heart    14.15 Adult VirginFemale Spermatheca    8.2 Adult InseminatedFemale Spermatheca    15.3 Adult Ovary    9.3 Adult Testis    7.6 Adult Male Accessory Gland    30.7 Adult Carcass    38.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    505.3 Larval Midgut no informative data Larval Hindgut    34.3 Larval Malpighian Tubules    6.4 Larval Fat Body    21.5 Larval Salivary Gland    19.5 Larval Trachea    9.7 Larval Carcass    69.675 Adult Head    171.8 Adult Eye    20.825 Adult Brain    586.7 Adult Thoracic-Abdominal Ganglion    422.9 Adult Crop    76.1 Adult Midgut    14.5 Adult Hindgut    40.5 Adult Malpighian Tubules    5.1 Adult Fat Body    19.4 Adult Salivary Gland no informative data Adult Heart    14.15 Adult VirginFemale Spermatheca    8.2 Adult InseminatedFemale Spermatheca    15.3 Adult Ovary    9.3 Adult Testis    7.6 Adult Male Accessory Gland    30.7 Adult Carcass    38.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    505.3 Larval Midgut no informative data Larval Hindgut    34.3 Larval Malpighian Tubules    6.4 Larval Fat Body    21.5 Larval Salivary Gland    19.5 Larval Trachea    9.7 Larval Carcass    69.675 Adult Head    171.8 Adult Eye    20.825 Adult Brain    586.7 Adult Thoracic-Abdominal Ganglion    422.9 Adult Crop    76.1 Adult Midgut    14.5 Adult Hindgut    40.5 Adult Malpighian Tubules    5.1 Adult Fat Body    19.4 Adult Salivary Gland no informative data Adult Heart    14.15 Adult VirginFemale Spermatheca    8.2 Adult InseminatedFemale Spermatheca    15.3 Adult Ovary    9.3 Adult Testis    7.6 Adult Male Accessory Gland    30.7 Adult Carcass    38.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0004624 expression level Tissue   Expression Level Larval Central Nervous System    505.3 Larval Midgut no informative data Larval Hindgut    34.3 Larval Malpighian Tubules    6.4 Larval Fat Body    21.5 Larval Salivary Gland    19.5 Larval Trachea    9.7 Larval Carcass    69.675 Adult Head    171.8 Adult Eye    20.825 Adult Brain    586.7 Adult Thoracic-Abdominal Ganglion    422.9 Adult Crop    76.1 Adult Midgut    14.5 Adult Hindgut    40.5 Adult Malpighian Tubules    5.1 Adult Fat Body    19.4 Adult Salivary Gland no informative data Adult Heart    14.15 Adult VirginFemale Spermatheca    8.2 Adult InseminatedFemale Spermatheca    15.3 Adult Ovary    9.3 Adult Testis    7.6 Adult Male Accessory Gland    30.7 Adult Carcass    38.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  505.3 Larval Midgut no informative data Larval Hindgut    34.3 Larval Malpighian Tubules    6.4 Larval Fat Body    21.5 Larval Salivary Gland    19.5 Larval Trachea    9.7 Larval Carcass    69.675 Adult Head    171.8 Adult Eye    20.825 Adult Brain  586.7 Adult Thoracic-Abdominal Ganglion    422.9 Adult Crop    76.1 Adult Midgut    14.5 Adult Hindgut    40.5 Adult Malpighian Tubules    5.1 Adult Fat Body    19.4 Adult Salivary Gland no informative data Adult Heart    14.15 Adult VirginFemale Spermatheca    8.2 Adult InseminatedFemale Spermatheca    15.3 Adult Ovary    9.3 Adult Testis    7.6 Adult Male Accessory Gland    30.7 Adult Carcass    38.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    505.3 Larval Midgut no informative data Larval Hindgut    34.3 Larval Malpighian Tubules    6.4 Larval Fat Body    21.5 Larval Salivary Gland    19.5 Larval Trachea    9.7 Larval Carcass    69.675 Adult Head    171.8 Adult Eye    20.825 Adult Brain    586.7 Adult Thoracic-Abdominal Ganglion    422.9 Adult Crop    76.1 Adult Midgut    14.5 Adult Hindgut    40.5 Adult Malpighian Tubules    5.1 Adult Fat Body    19.4 Adult Salivary Gland no informative data Adult Heart    14.15 Adult VirginFemale Spermatheca    8.2 Adult InseminatedFemale Spermatheca    15.3 Adult Ovary    9.3 Adult Testis    7.6 Adult Male Accessory Gland    30.7 Adult Carcass    38.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    505.3 Larval Midgut no informative data Larval Hindgut    34.3 Larval Malpighian Tubules    6.4 Larval Fat Body    21.5 Larval Salivary Gland    19.5 Larval Trachea    9.7 Larval Carcass    69.675 Adult Head    171.8 Adult Eye    20.825 Adult Brain    586.7 Adult Thoracic-Abdominal Ganglion    422.9 Adult Crop    76.1 Adult Midgut    14.5 Adult Hindgut    40.5 Adult Malpighian Tubules    5.1 Adult Fat Body    19.4 Adult Salivary Gland no informative data Adult Heart    14.15 Adult VirginFemale Spermatheca    8.2 Adult InseminatedFemale Spermatheca    15.3 Adult Ovary    9.3 Adult Testis    7.6 Adult Male Accessory Gland    30.7 Adult Carcass    38.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    171.8   NA  Eye    20.825   NA  Brain    586.7   505.3  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    422.9   NA  Crop    76.1   no informative data  Midgut    14.5   34.3  Hindgut    40.5   6.4  Malpighian Tubules    5.1   21.5  Fat Body    19.4   19.5  Salivary Gland    no informative data   NA  Heart    14.15   9.7  Trachea    NA   NA  VirginFemale Spermatheca    8.2   NA  InseminatedFemale Spermatheca    15.3   NA  Ovary    9.3   NA  Testis    7.6   NA  Male Accessory Gland    30.7   69.675  Carcass    38.7 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_29
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004624 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18069-RC
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL429BD, Tn10\tetRScer\UAS.T:Hsim\VP16 CaMKIIT287D.Tn10\tetO lethal, with Scer\GAL4Appl.G1a CaMKIIT287D.Scer\UAS lethal, with Scer\GAL4elav-C155 CaMKIIT287D.Scer\UAS lethal, with Scer\GAL4elav-C155, Tn10\tetRScer\UAS.T:Hsim\VP16 CaMKIIT287D.Tn10\tetO lethal, with Scer\GAL4MJ85b, Tn10\tetRScer\UAS.T:Hsim\VP16 CaMKIIT287D.Tn10\tetO lethal | recessive CaMKIIunspecified viable CaMKII118E-9 viable, with Scer\GAL4Appl.G1a CaMKIIT287A.Scer\UAS viable, with Scer\GAL4elav-C155 CaMKIIT287A.Scer\UAS viable, with Scer\GAL4pnr-MD237 CaMKIIGD9506 Other Phenotypes Allele courtship behavior defective, with Scer\GAL430Y, Tn10\tetRScer\UAS.T:Hsim\VP16 CaMKIIT287D.Tn10\tetO courtship behavior defective, with Scer\GAL4MJ85b, Tn10\tetRScer\UAS.T:Hsim\VP16 CaMKIIT287D.Tn10\tetO courtship behavior defective | male | tetracycline conditional, with Scer\GAL430Y, Scer\GAL80Cha.PK, Tn10\tetRScer\UAS.T:Hsim\VP16 CaMKIIT287D.Tn10\tetO courtship behavior defective | male | tetracycline conditional, with Scer\GAL430Y, Tn10\tetRScer\UAS.T:Hsim\VP16 CaMKIIT287D.Tn10\tetO locomotor behavior defective | third instar larval stage, with Scer\GAL4Appl.G1a CaMKIIT287D.Scer\UAS locomotor behavior defective | third instar larval stage, with Scer\GAL4elav-C155 CaMKIIT287D.Scer\UAS memory defective, with Scer\GAL4CaMKII.7 CaMKIIdsRNA.Scer\UAS neuroanatomy defective, with Scer\GAL4109(2)80 CaMKIIScer\UAS.cKa CaMKIIT287A.Scer\UAS CaMKIIT287D.Scer\UAS neuroanatomy defective, with Scer\GAL4D42 CaMKIIT287D.Scer\UAS neuroanatomy defective, with Scer\GAL4unspecified CaMKIIT287D.Scer\UAS neurophysiology defective, with Scer\GAL4Appl.G1a CaMKIIT287D.Scer\UAS neurophysiology defective, with Scer\GAL4D42 CaMKIIT287D.Scer\UAS neurophysiology defective, with Scer\GAL4elav-C155 CaMKIIT287D.Scer\UAS neurophysiology defective | third instar larval stage, with Scer\GAL4how-24B CaMKIIT287D.Scer\UAS small body, with Scer\GAL4MJ85b, Tn10\tetRScer\UAS.T:Hsim\VP16 CaMKIIT287D.Tn10\tetO Phenotype manifest in Allele adult abdomen, with Scer\GAL429BD, Tn10\tetRScer\UAS.T:Hsim\VP16 CaMKIIT287D.Tn10\tetO adult heart | P-stage CaMKII102EFb-1 axon, with Scer\GAL4D42 CaMKIIT287D.Scer\UAS bouton, with Scer\GAL4D42 CaMKIIT287D.Scer\UAS bouton | supernumerary, with Scer\GAL4elav-C155 CaMKIIT287D.Scer\UAS embryonic/larval neuromuscular junction, with Scer\GAL4elav-C155 CaMKIIT287D.Scer\UAS embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4how-24B CaMKIIT287D.Scer\UAS filopodium & dendrite, with Scer\GAL4109(2)80 CaMKIIScer\UAS.cKa CaMKIIT287A.Scer\UAS CaMKIIT287D.Scer\UAS motor neuron, with Scer\GAL4D42 CaMKIIT287D.Scer\UAS neuromuscular junction, with Scer\GAL4unspecified CaMKIIT287D.Scer\UAS neuromuscular junction & bouton, with Scer\GAL4unspecified CaMKIIT287D.Scer\UAS neuromuscular junction & postsynaptic membrane, with Scer\GAL4unspecified CaMKIIT287D.Scer\UAS synapse, with Scer\GAL4D42 CaMKIIT287D.Scer\UAS wing, with Scer\GAL429BD, Tn10\tetRScer\UAS.T:Hsim\VP16 CaMKIIT287D.Tn10\tetO
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of CaMKII Class Mutagen Stocks Known lesion CaMKII[EY14097] P-element activity 1 -- CaMKII102EFb-1 0 Yes CaMKII118E-9 0 -- CaMKIICPTI000944 piggyBac transposase 0 Yes CaMKIIunspecified 0 --
Alleles Carried on Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CaMKII Class Mutagen Stocks Known lesion CaMKIIGD9506 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CaMKIIT287D.Scer\UAS in vitro construct - regulatory fusion in vitro construct - coding region fusion 2 Yes CaMKIIGL00237 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CaMKIIJF03336 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CaMKIIKK107335 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CaMKIIScer\UAS.cKa in vitro construct - regulatory fusion 1 Yes CaMKIIT287A.Scer\UAS in vitro construct - regulatory fusion in vitro construct - coding region fusion 1 Yes CaMKII3'UTR.Scer\UAS.T:Avic\GFP-EYFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes CaMKII3'UTR.Scer\UAS.T:MS2\MCP.BS in vitro construct - regulatory fusion 0 Yes CaMKIIdsRNA.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes CaMKIINUT.Scer\UAS.T:Avic\GFP-EYFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes CaMKIIScer\UAS.T:MS2\MCP.BS in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes CaMKIIT287D.Tn10\tetO in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9506} NA P{KK107335} NA P{tetO-CaMKII.T287D} NA P{TRiP.GL00237} NA P{TRiP.JF03336} NA P{UAS-CaMKII.3'UTR.EYFP} NA P{UAS-CaMKII.3'UTR.MS2bs} NA P{UAS-CaMKII.EYFP.NUT} NA P{UAS-CaMKII.hpn} NA P{UAS-CaMKII.mbs2bs} NA P{UAS-CaMKII.R3} NA P{UAS-CaMKII.T287A} NA P{UAS-CaMKII.T287D} NA reporter construct P{CaMKII-lacZ.7} No characterization construct P{CaMKII-GAL4.7} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}CaMKIIEY14097 NA miscellaneous insertions P{hsp26-pt-T}CaMKII118E-9 NA PBac{602.P.SVS-1}CaMKIICPTI000944 NA
Gene Ontology: Function, Process & Cellular Component ( 19 unique terms )
Terms Based on Experimental Evidence ( 13 terms )
Molecular Function
CV term Evidence References
calmodulin-dependent protein kinase activity inferred from direct assay AND inferred from sequence or structural similarity (Cho et al., 1991) protein serine/threonine kinase activity inferred from direct assay (Koh et al., 1999)
Biological Process
CV term Evidence References
learning or memory inferred from mutant phenotype (Griffith et al., 1993) long-term memory inferred from mutant phenotype (Ashraf et al., 2006) male courtship behavior inferred from mutant phenotype (Mehren and Griffith, 2004, Mehren and Griffith, 2006) regulation of filopodium assembly inferred from mutant phenotype (Andersen et al., 2005) regulation of ovulation inferred from genetic interaction with Oamb (Lee et al., 2009) synaptic transmission inferred from mutant phenotype (Koh et al., 1999)
Cellular Component
CV term Evidence References
axon inferred from direct assay (Ashraf et al., 2006) dendrite inferred from direct assay (Ashraf et al., 2006) plasma membrane inferred from direct assay (Khanna et al., 2010) postsynaptic membrane inferred from direct assay (Ashraf et al., 2006) presynaptic active zone inferred from direct assay (Ashraf et al., 2006)
Terms Based on Predictions or Assertions ( 9 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441 (FlyBase Curators et al., 2004-) calmodulin binding inferred from electronic annotation with InterPro:IPR013543 (FlyBase Curators et al., 2004-) traceable author statement (Montell, 1999) calmodulin-dependent protein kinase activity inferred from sequence or structural similarity with NCBI:NP_001212 (FlyBase, 1992-) protein serine/threonine kinase activity non-traceable author statement (Morrison et al., 2000)
Biological Process
CV term Evidence References
courtship behavior traceable author statement (Sokolowski, 2001) learning or memory non-traceable author statement (Sokolowski, 2001) neuromuscular junction development non-traceable author statement (Sokolowski, 2001) protein phosphorylation inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR008271, InterPro:IPR013543 (FlyBase Curators et al., 2004-) non-traceable author statement (Morrison et al., 2000) traceable author statement (Montell, 1999)
Cellular Component
CV term Evidence References
calcium- and calmodulin-dependent protein kinase complex inferred from sequence or structural similarity (Cho et al., 1991)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CaMKII allele Gene References CaMKIIScer\UAS.cKa mys (Beumer et al., 2002) CaMKIIT287D.Scer\UAS GluRIIA (Haghighi et al., 2003) Rat\CamKII-I (Haghighi et al., 2003)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68654 DroID - A comprehensive database of gene and protein interactions. • FBgn0004624 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43828
Orthologs
Genome-wide drosophilid orthologs	Dana\GF22825 Dere\GG16421 Dgri\GH23972 Dmoj\GI14101 Dper\GL18383 Dsec\GM13012 Dsim\GD24361 Dvir\GJ20463 Dwil\GK13605 Dyak\GE14490
Curated drosophilid orthologs	Dpse\GA14780
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL013823-PA Aedes aegypti (mosquito) AAEL013824-PA Aedes aegypti (mosquito) AGAP000028-PA Anopheles gambiae (mosquito) XP_624082.2 Apis mellifera (honey bee) XP_001945479.1 Acyrthosiphon pisum (pea aphid) At1g50700.1 Arabidopsis thaliana (wall cress) At1g61950.1 Arabidopsis thaliana (wall cress) 120049 Branchiostoma floridae (lancelet) BGIBMGA000408-PA Bombyx mori (silk worm) ENSBTAP00000039621 Bos taurus (bovine) CN14372 Caenorhabditis brenneri (small nematode) CN19553 Caenorhabditis brenneri (small nematode) CBP01170 Caenorhabditis briggsae (nematode) ENSCAFP00000017850 Canis familiaris (dog) Chro.30121 Cryptosporidium hominis (obligate parasite) ENSCINP00000004087 Ciona intestinalis (sea squirt) JA03878 Caenorhabditis japonica (nematode) CMF051C Cyanidioschyzon merolae (red alga) cgd3_920 Cryptosporidium parvum (protozoan parasite) CPIJ017648 Culex pipens (mosquito) ENSCPOP00000003730 Cavia porcellus (guinea pig) RP32809 Caenorhabditis remanei (nematode) 184782 Capitella spl (polychaete worm) 198415 Daphnia pulex (daphnia) ENSDARP00000089438 Danio rerio (zebra fish) ENSECAP00000001198 Equus caballus (horse) ENSGACP00000002103 Gymnopilus aculeatus (mushroom) ENSGALP00000008145 Gallus gallus (chicken) 155666 Hypsipyla robusta (cedar shoot borer) ENSP00000339740 Homo sapiens (human) ISCW015680-PA Ixodes scapularis (deer tick) 106573 Lottia gigantea (owl limpet) LmjF27.2470 Leishmania major (virus) 32484 Monocosta brevicollis (choanoflagellate) ENSMODP00000000649 Monodelphis domestica (gray opossum) ENSMMUP00000011271 Macaca mulatta (rhesus monkey) ENSMUSP00000019133 Mus musculus (house mouse) 220432 Nematostella vectensis (starlet anemone) XP_001606166.1 Nasonia vitripennis (wasp) ENSOANP00000003644 Ornithorynchus anatinus (platypus) ENSORLP00000013394 Oryzias latipes (japanese killifish) LOC_Os01g59360.1 Oryza sativa (asian rice) PFF0520w Plasmodium falciparum (protozoal parasite) PHUM001971-PA Pediculus humanus (human body louse) PP22650 Pristionchus pacificus (nematode) 225603 Physcomitrella patens (moss) 86218 Physcomitrella patens (moss) ENSPPYP00000016769 Pongo pygmaeus (orangutan) 81648 Phytophthora ramorum (sudden oak death pathogen) 143401 Phytophthora sojae (root rot pathogen) 206507 Populus trichocarpa (black cottonwood) 410888 Populus trichocarpa (black cottonwood) ENSPTRP00000028140 Pan troglodytes (chimpanzee) PVX_000555 Plasmodium vivax (protozoal parasite) ENSRNOP00000005359 Rattus norvegicus (norway rat) 4892551 Sorghum bicolor (sorghum) 5036814 Sorghum bicolor (sorghum) Smp_011660.1 Schistosoma mansoni (trematode parasite) 50756 Trichoplax adhaerens (metazoa) TA16180 Theileria annulata (apicomplexan parasite) XP_966888.1 Tribolium castaneum (red flour beetle) Tc00.1047053506513.50 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053508919.70 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000010420 Tetraodon nigroviridis (green spotted pufferfish) TP01_1073 Theileria parva (parasitic protozoan) 24056 Thalassiosira pseudonana (marine diatom) ENSTRUP00000018844 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000041159 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11719 NV14677 LH14652 ISCW015680 FBgn0232094 FBgn0215613 FBgn0207603 FBgn0167943 JGI_V11_198415 FBgn0155984 FBgn0136855 FBgn0131429 FBgn0108653 FBgn0099819 CPIJ017648 BGIBMGA000408 ACYPI002846 GB17817 AGAP000028 AAEL013824 AAEL013823 PHUM536570 GLEAN_02587
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	29662 w*; P{UAS-CaMKII.R3}2 29663 w*; P{UAS-CaMKII.T287A}3B3 29664 w*; P{UAS-CaMKII.T287D}6B1 29665 w*; P{UAS-CaMKII.T287D}10A 29401 y1 v1; P{TRiP.JF03336}attP2 22325 y1 w1118; P{EPgy2}CaMKIIEY14097 35330 y1 sc* v1; P{TRiP.GL00237}attP2/TM3, Sb1
VDRC	v100265 P{KK107335}VIE-260B v38930 w1118 P{GD9506}v38930 v47280 w1118; P{GD9506}v47280
Genomic Clones ( 2 )
	BACR13D24 BACR22J20 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 480 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP15240 LD31422
Other clones	FI03620
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH03272 GM04788 HL02109 LD02711 LD02905 LD11702 LD11978 LD15615 LD20445 LD32233 LD43659 LP14194 RE01603 RE02120 RE05154 RE08235 RE09731 RE11014 RE14260 RE15101 RE15125 RE18582 RE19532 RE19562 RE21168 RE21402 RE31059 RE31083 RE31228 RE34660 RE36529 RE42641 RE47542 RE49368 RE51268 RE52712 RE53679 RE54263 RE56988 RE59418 RE60749 RE61586 RE62417 RE63237 RE64870 RE65923 RE67455 RE68056 RE69026 RE69513 RE69531 RE69538 RE70249 RE71073 RE73744 RH24457
Other clones	5141 11753 13071 14482 14746 15341 16606 16873 18226 18515 19792 19793 28414 28500 28784 28946 29058 29488 29987 31760 32662 33756 34449 34932 35122 35631 35651 36734 37888 39185 39325 41461 41882 42199 44019 44716 46223 53130 53855 54788 54825 55257 56896 58279 59456 59721 61535 62231 62618 64359 64917 66469 66940 70457 70745 71035 71353 74131 75103 75299 76162 76354 76604 76693 76731 78226 82719 83302 84149 84322 97073 99302 99396 99511 100417 105124 108152 108653 109266 117418 117882 117902 118102 118343 121270 122378 124141 125206 144362 145667 146237 147390 148141 149346 153299 153605 153606 156681 158138 158466 160918 161222 167054 173127 173649 174700 177463 178217 183256 190444 191523 191858 191971 192379 194683 211072.1 214319.2 214339.3 214349.1 214533.1 272901 274062 276983 277208 CK01.8A.G12 CK01.10C.A6 CK01.12A.C12 CK01.18D.G10 CK01.24C.G12 CK01.27C.C3 CK01.34C.G8 CK01.36A.C8 CK01.49B.C4 CK01.49B.G8 CK01.51B.D12 CK01.64A.H10 CK01.64C.G9 CK01.64D.E12 CK01.71D.F2 CK01.72C.C6 CK01.74C.B10 CK01.75A.C6 CK01.77B.G6 CK01.78B.F2 CK01.83C.G10 CK01.89B.D1 CK01.89B.H3 CK01.89D.C10 CK01.93C.H6 CK01.95A.F9 CK01.95A.H8 CK01.97A.H11 CK01.97C.F3 CK01.99D.D2 CK01.102C.B8 CK01.110B.E6 CK01.113A.H9 CK01.114D.C12 CK01.118A.C2 CK01.120D.G1 CK01.121A.A12 CK01.129D.C2 CK01.130A.E6 CK01.143B.B12 CK01.167A.F7 CK01.169C.D6 Dmel_dig_013157_0594_1555 Dmel_neb_009217_0868_1993 Dmel_neb_014523_0879_0843 EC22755 EC052847 EC053068 EC053544 EC251535 EC251964 EC252225 EC252400 EC252902 EC252927 EC253510 EC253760 EC255271 EC255459 EC256630 EC256683 EC258070 EC258323 EC258666 EC258939 EC259253 EC259274 EC259420 EK003733 EK005006 EK012635 EK041442 EK041460 EK043146 EK049006 EK053207 EK053420 EK056940 EK057443 EK058637 EK058843 EK060953 EK064662 EK066559 EK070110 EK070123 EK070741 EK072963 EK074017 EK074046 EK075331 EK075522 EK076845 EK084545 EK086340 EK088708 EK089731 EK092425 EK096141 EK100351 EK102124 EK106404 EK112655 EK113407 EK114534 EK115401 EK116001 EK116524 EK116706 EK116803 EK117534 EK118204 EK119528 EK127947 EK128933 EK129338 EK130523 EK131156 EK132041 EK132401 EK132719 EK135902 EK136327 EK136724 EK137250 EK137506 EK137524 EK137549 EK138954 EK142930 EK146546 EK146603 EK146641 EK147114 EK154857 EK156218 EK157329 EK159844 EK160255 EK164047 EK165016 EK165508 EK166253 EK170356 EK170432 EK173504 EK173541 EK176926 EK179711 EK180612 EK180727 EK183209 EK184549 EK186745 EK187864 EK188113 EK190038 EK194456 EK194831 EK198139 EK199039 EK199216 EK199908 EK200209 EK205540 EK206638 EK206915 EK206934 EK207056 EK208906 EK211513 EK216410 EK217011 EK219663 EK220802 EK221862 EK222250 EK222847 EK229988 EK236616 EK237124 EK237338 EK237614 EK237737 EK239004 EK241411 EK242605 EK244107 EK245556 EK246629 EK247452 EK248362 EK248848 EK249445 EK250517 EK253542 EK254725 EK256651 EK256939 EK257210 EK261347 EK262204 EK264625 EK264739 EK272117 EK272739 EK278034 EK288137 EK290644 EK291607 EK291729 EK291837 EK292050 EK292730 EK294417 EK294823 EK294964 EK295201 EK297916 EK299732 EK304026 EK304124 EP00639 EP00714 EP02138 EP04450 EP08945 EP09130 EP09143 EP09208 EP09548 EP10829 EP11057 EP11153 EP11629 EP12308 EP13447 EP13616 EP13622 EP13730 EP13860 EP16341 EP16710 EP19225 EP21241 EP22344 ESG012c.E21_G01 ESG018b.E21.1_C02 FGM001H06 GM04335 IP15340 IP15440 IP15540 RC0-DA0001-120700-110-C06 RC0-DA0001-120700-110-F03 RP004022997 RP004081678 RP004097909 RP004113026 RP004115860 RP004125064 RP004126778 RP004129905 RP004130253 RP004137637 RP004152782 RP004155621 RP004174427 RP004184273 RP004195470 RP004214318 RP004217096 RP004229498 RP004230481 RP004232697 RP004233216 RP004245735 RP004250067 RP004265423 RP004293374 RP004312600 RP004325617 RP004328044 RP004335837 RP004358017 RP004360663 RP004377356 RP004401286 RP004416912 RP004444730 RP004445490 RP004450631 RP004455808 RP004456607 RP004485877 RP004512573 RP004536656
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004624 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43828
Antibody Information
	monoclonal (Takamatsu et al., 2003)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: CaMKII CG18069 (Zhao, 1999.11)
Source for database merge of	Source for merge of: CaMKII l(4)102EFb (Johnson et al., 2002)
Additional comments
Other Comments
	CaMKII activity increases levels of p-Akt1 in larval motor nerve terminals in a Fak56D-dependent manner. (Chun-Jen Lin et al., 2011) Nonsense-mediated mRNA decay (NMD) down-regulates a distinct splice isoform(s) of this gene. (Hansen et al., 2009) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) CaMKII protein phosphorylates eag protein at Thr-787. (Wang et al., 2002) dlg1 and CaMKII protein colocalise at synapses and exist in the same protein complex. (Koh et al., 1999) The CaMKII protein is the kinase that phosphorylates phosrestin 1, the product of the Arr2 gene. The earliest light induced phosphorylation in the photoreceptor is the phosphorylation of a single site of Arr2 by a kinase dependent on both Ca2+ and calmodulin. The kinase that is responsible for the phosphorylation of Arr2 is CaMKII. Results suggest CaMKII may play a role in regulating light adaptation in photoreceptors. (Kahn and Matsumoto, 1997) The basic catalytic functions of six CaMKII isoforms are characterised. Results reveal the protein family is functionally homologous to the rat CaM kinase II. (Gupta Roy and Griffith, 1996) Isoforms of CaMKII have similar biochemical properties, they exhibit differential activity by mutant Cam proteins. Data supports a role for the C-terminal variable region of CaMKII in the mechanism of activation and demonstrate that stimulation of CaMKII catalytic activity by Cam is a multistep process, with separate binding and activation steps. (GuptaRoy et al., 1996) A key regulator of plasticity in synaptic physiology and behaviour, alterations in its activity produce pleiotropic effects that involve synaptic transmission and development as well as various aspects of behaviour. (Greenspan et al., 1995) A fifth form of CaMKII is isolated, it is maternally derived and is identical to the 530 amino acid polypeptide except for the missing exon 11. (Takamatsu et al., 1994) Study of transformed lines expressing a specific inhibitor of CaMKII (Rat\CamKII-I) suggests an important role of CaMKII in the stability of synaptic transmission. (Wang et al., 1994) CaMKII activity can be inhibited by a synthetic peptide corresponding to the rat autoinhibitory domain of CaM kinase. Results suggest that CaMKII activity is required for plastic behaviour in an intact animal. (Griffith et al., 1993) CaMKII is alternatively spliced, producing a variety of protein isoforms. (Griffith and Greenspan, 1993) A large gene with at least 16 exons encoding 4 forms of Cam kinase by alternate splicing. (Ohsako et al., 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079896 NM_166810 NM_166811 NM_166812 NM_166813 NM_001014696 NM_001169360 NM_001169361 NM_001169362 RefSeq (Proteins) • NP_524635 NP_726633 NP_726634 NP_726635 NP_726636 NP_001014696 NP_001162831 NP_001162832 NP_001162833 DDBJ / EMBL / GenBank • AA951116 AAA51459 AAA64214 AAB28244 AAB28245 AAB28246 AAB28247 AAB28248 AAF59388 AAF59388.2 AAF59388.3 AAF59389 AAF59389.2 AAF59389.3 AAF59390 AAF59390.2 AAN06568 AAN06569 AAX53595 AC010838 ACZ95100 ACZ95101 ACZ95102 AW943083 BAA02593 BAA02594 BAA02595 BAA02596 D13330 D13331 D13332 D13333 M74583 S65712 S65716 S65717 S65719 S65724 U22420 Entrez Gene - A searchable database of RefSeq genes. • 43828 UniProtKB/Swiss-Prot • Q00168 UniProtKB/TrEMBL • A4V133 A4V134 D1YSG7 D1YSG8 Q24045
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Calcium/calmodulin-dependent/calcium-dependent protein kinase (IPR020636) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442) Calcium/calmodulin-dependent protein kinase II, association-domain (IPR013543)
Linkouts
	BioGRID - A database of protein and genetic interactions • 68654 DroID - A comprehensive database of gene and protein interactions. • FBgn0004624 DRSC - Results from RNAi screens. • FBgn0004624 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004624 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18069-RC FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004624 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43828 InParanoid A subset of ortholog calls from InParanoid. • AAEL013823-PA Aedes aegypti (mosquito) AAEL013824-PA Aedes aegypti (mosquito) AGAP000028-PA Anopheles gambiae (mosquito) XP_624082.2 Apis mellifera (honey bee) XP_001945479.1 Acyrthosiphon pisum (pea aphid) At1g50700.1 Arabidopsis thaliana (wall cress) At1g61950.1 Arabidopsis thaliana (wall cress) 120049 Branchiostoma floridae (lancelet) BGIBMGA000408-PA Bombyx mori (silk worm) ENSBTAP00000039621 Bos taurus (bovine) CN14372 Caenorhabditis brenneri (small nematode) CN19553 Caenorhabditis brenneri (small nematode) CBP01170 Caenorhabditis briggsae (nematode) ENSCAFP00000017850 Canis familiaris (dog) Chro.30121 Cryptosporidium hominis (obligate parasite) ENSCINP00000004087 Ciona intestinalis (sea squirt) JA03878 Caenorhabditis japonica (nematode) CMF051C Cyanidioschyzon merolae (red alga) cgd3_920 Cryptosporidium parvum (protozoan parasite) CPIJ017648 Culex pipens (mosquito) ENSCPOP00000003730 Cavia porcellus (guinea pig) RP32809 Caenorhabditis remanei (nematode) 184782 Capitella spl (polychaete worm) 198415 Daphnia pulex (daphnia) ENSDARP00000089438 Danio rerio (zebra fish) ENSECAP00000001198 Equus caballus (horse) ENSGACP00000002103 Gymnopilus aculeatus (mushroom) ENSGALP00000008145 Gallus gallus (chicken) 155666 Hypsipyla robusta (cedar shoot borer) ENSP00000339740 Homo sapiens (human) ISCW015680-PA Ixodes scapularis (deer tick) 106573 Lottia gigantea (owl limpet) LmjF27.2470 Leishmania major (virus) 32484 Monocosta brevicollis (choanoflagellate) ENSMODP00000000649 Monodelphis domestica (gray opossum) ENSMMUP00000011271 Macaca mulatta (rhesus monkey) ENSMUSP00000019133 Mus musculus (house mouse) 220432 Nematostella vectensis (starlet anemone) XP_001606166.1 Nasonia vitripennis (wasp) ENSOANP00000003644 Ornithorynchus anatinus (platypus) ENSORLP00000013394 Oryzias latipes (japanese killifish) LOC_Os01g59360.1 Oryza sativa (asian rice) PFF0520w Plasmodium falciparum (protozoal parasite) PHUM001971-PA Pediculus humanus (human body louse) PP22650 Pristionchus pacificus (nematode) 225603 Physcomitrella patens (moss) 86218 Physcomitrella patens (moss) ENSPPYP00000016769 Pongo pygmaeus (orangutan) 81648 Phytophthora ramorum (sudden oak death pathogen) 143401 Phytophthora sojae (root rot pathogen) 206507 Populus trichocarpa (black cottonwood) 410888 Populus trichocarpa (black cottonwood) ENSPTRP00000028140 Pan troglodytes (chimpanzee) PVX_000555 Plasmodium vivax (protozoal parasite) ENSRNOP00000005359 Rattus norvegicus (norway rat) 4892551 Sorghum bicolor (sorghum) 5036814 Sorghum bicolor (sorghum) Smp_011660.1 Schistosoma mansoni (trematode parasite) 50756 Trichoplax adhaerens (metazoa) TA16180 Theileria annulata (apicomplexan parasite) XP_966888.1 Tribolium castaneum (red flour beetle) Tc00.1047053506513.50 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053508919.70 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000010420 Tetraodon nigroviridis (green spotted pufferfish) TP01_1073 Theileria parva (parasitic protozoan) 24056 Thalassiosira pseudonana (marine diatom) ENSTRUP00000018844 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000041159 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /newgene/camks2-1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43828 modMine - Data generated by the modENCODE project. • FBgn0004624 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11719 NV14677 LH14652 ISCW015680 FBgn0232094 FBgn0215613 FBgn0207603 FBgn0167943 JGI_V11_198415 FBgn0155984 FBgn0136855 FBgn0131429 FBgn0108653 FBgn0099819 CPIJ017648 BGIBMGA000408 ACYPI002846 GB17817 AGAP000028 AAEL013824 AAEL013823 PHUM536570 GLEAN_02587
Synonyms & Secondary IDs ( 31 )
Reported As
Symbol Synonym	Ca2+/calmodulin-dependent protein kinase II (Ohsako, 1993.3.4, Ohsako, 1993.3.4, Ohsako, 1993.3.4, Ohsako, 1993.3.4) Calcium/calmodulin-dependent protein kinase (Morley and Montgomery, 2001) calcium/calmodulin-dependent protein kinase II (Griffith, 1993.11.23, Griffith, 1993.11.23, Griffith, 1993.11.23, Griffith, 1993.11.23, Griffith, 1993.11.23) CaM (Greenspan et al., 1995, Cho et al., 1991) Cam   CaM II (Coleman and Neckameyer, 2001) CaMKII (Riddle et al., 2008, Pradeep et al., 2009, White-Grindley and Si, 2006, Ashraf et al., 2006, Ashraf et al., 2006, GuptaRoy et al., 2000, Broughton et al., 2003, Bostrom et al., 2009, Mehren and Griffith, 2004, Lee and Han, 2008, van der Plas et al., 2006, Dubnau et al., 2003, Harrisingh et al., 2007, Marques, 2005, Park et al., 2002, Johansson et al., 2007, Barbee et al., 2006, Hodge et al., 2006, Shakiryanova et al., 2007, Lee et al., 2009, Hall, 2003, Hansen et al., 2009, Ruedi and Hughes, 2009, Mehren and Griffith, 2006, Yao and Wu, 2001, Baker et al., 2007, Wong et al., 2009, Sun et al., 2004, Morimoto et al., 2010, Kazama et al., 2003, Morimoto-Tanifuji et al., 2004, Chun-Jen Lin et al., 2011, Yang et al., 2010) CAMKII (Kalinovsky and Scheiffele, 2004, Jasper et al., 2002) CaMK-II (Tombes et al., 2003) camKII (Solano et al., 2003, Locke et al., 2000) CaM KII (Ejima and Griffith, 2003, Rachidi et al., 1999) CamKII (Haghighi et al., 2002, Dubnau and Tully, 1998, Lee et al., 2009) CaMK II (Kahn et al., 1998, Weber et al., 2007) Camkii (Schwartz et al., 2009) CAMKIId (Morrison et al., 2000) CamKIIα   CAMKIIα (Sutton and Schuman, 2006) CaM kinase (Broughton et al., 1996) CDPK1 (Winge, 1995.3.9) CG18069 (Morrison et al., 2000, Hansen et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009, Khanna et al., 2010, Ni et al., 2011.7.19, Cammarato et al., 2011) dCaMKII (Takamatsu et al., 2002, Iourgenko and Levin, 2000, Takamatsu et al., 2003) DCK (Cho, 1994.10.30)
Name Synonym	Ca2+/Calmodulin-dependent protein kinase II (Lee and Han, 2008) Ca2+/calmodulin-dependent protein kinase II (Yao and Wu, 2001) Calcium/calmodulin-dependent protein kinase (Khanna et al., 2010) Calcium/calmodulin-dependent protein kinase II (Cammarato et al., 2011) calcium/ calmodulin-dependent protein kinase II (GuptaRoy et al., 2000) calcium/calmodulin-dependent protein kinase II (Broughton et al., 2003, Bostrom et al., 2009, Kazama et al., 2003, Morimoto-Tanifuji et al., 2004, Takamatsu et al., 2003) calmodulin-dependent kinase (Harris and Lim, 2001) calmodulin-dependent protein kinase II (Harrisingh et al., 2007) Calmodulin kinase II (Shakiryanova et al., 2007) CaM kinase (Griffith and Greenspan, 1993, Griffith et al., 1993) CaM kinase II (Xu et al., 1998, Greenspan et al., 1995, Takamatsu et al., 1994, Pu et al., 2006) CaM-kinase-II (Hall, 2003)
Secondary FlyBase IDs
References ( 151 )
Generate a list of	All references relating to this gene ( 151 )
List References by type	Research paper  ( 69 ) Supplementary material  ( 9 ) Review  ( 25 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 22 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 11 ) Curated genome annotation  ( 2 ) Computer file  ( 1 ) Conference report  ( 1 ) Automatic genome annotation  ( 1 ) Letter  ( 1 )
Recent research papers ( 3 )
	Chun-Jen Lin et al., 2011, Genetics 188(3): 601--613 The Metabotropic Glutamate Receptor Activates the Lipid Kinase PI3K in Drosophila Motor Neurons Through the Calcium/Calmodulin-Dependent Protein Kinase II and the Nonreceptor Tyrosine Protein Kinase DFak. [FBrf0214227] Morimoto et al., 2010, Neuroscience 165(4): 1284--1292 Subunit-specific and homeostatic regulation of glutamate receptor localization by CaMKII in Drosophila neuromuscular junctions. [FBrf0209866] Yang et al., 2010, EMBO J. 29(18): 3196--3207 Metabolic regulation of Drosophila apoptosis through inhibitory phosphorylation of Dronc. [FBrf0211843] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...