l(1)zw10, mit(1)15, EG:BACR7C10.3 , zw-10, abe
a subunit of the RZZ complex located at the kinetochores of chromosomes - the RZZ complex plays an essential role in the spindle assembly checkpoint that ensures proper connections between chromosomes and the mitotic spindle. - found on the Golgi stacks and endoplasmic reticulum where it functions in membrane formation and trafficking.
Gene model reviewed during 5.47
Gene model reviewed during 5.50
There is only one protein coding transcript and one polypeptide associated with this gene
721 (aa); 85 (kD observed)
Component of the RZZ complex composed of rod, Zw10 and Zwilch.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Zw10 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Zw10 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Zw10 mit(1)15
Source for merge of: mit(1)15 CG9900
Renamed to 'Zw10' to replace the placeholder symbol 'mit(1)15' and to better reflect usage in the literature.
inter se allelism tests have not been performed.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in S2R+ cells: cell morphology is aberrant, indicative of a failure in cell cycle/mitosis progression. This phenotype is not seen in Kc167 cells.
Candidate gene for testis length quantitative trait locus.
mit(1)15 can localise to mini-chromosomes that contain the fully functional centromere and to acentric mini-chromosomes that contain only 225-290kb of sub-telomeric DNA.
mit(1)15 is required for proper chromosome segregation during both meiotic divisions. Function in chromosome segregation must affect both separation of sister chromatids (during mitosis and meiosis II) and the separation of homologous chromosomes (during meiosis I).
High levels of meiotic nondisjunction due to delay of chromosome migration to the poles at anaphase. Also there is a high frequency of cytokinesis failure.
Mutations in mit(1)15 can cause essentially random mitotic segregation of chromosomes.
Based on map position and phenotype mit(1)15 is thought to be synonymous with abe.
One of a group of fourteen loci identified as temperature-sensitive lethal mutations (Baker) that exhibit, at semirestrictive temperatures, elevated frequencies of clones of homozygous mwh cells in the wings of surviving mit(1);mwh/+ males and of y clones and y//mwh twin spots in the abdomens of y mit(1); T(1;3)scJ4, y+ mwh/+ males. The presence of large clones is consistent with origin via mitotic exchange, mitotic nondisjunction of both homologues, or mutation; twin spots are not expected to result from somatic mutation; only mitotic nondisjunction produces y Sb+ clones in T(1;3)scJ4, y+ Sb/+. Preponderance of small clones suggests origin via chromosome breakage.