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Gene Dmel\ogre

General Information
Symbol	Dmel\ogre	Species	D. melanogaster
Name	optic ganglion reduced	Annotation symbol	CG3039
Feature type	protein_coding_gene	FlyBase ID	FBgn0004646
Gene Model Status	Current	Stock availability	13 publicly available
Also Known As	l(1)ogre, inx1
Genomic Location
Chromosome (arm)	X	Recombination map	1-18.8
Cytogenetic map	6E4-6E4	Sequence location	X:6,867,648..6,885,351 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene optic ganglion reduced is referred to in FlyBase by the symbol Dmel\ogre (CG3039, FBgn0004646). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: phototransduction. 15 alleles are reported. The phenotypes of these alleles are annotated with: lamina monopolar neuron; central nervous system; optic lobe; photoreceptor cell. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: Innexin. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult fat body, larval trachea, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, larval/adult hindgut, adult heart, larval salivary gland, adult spermathecae, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1628323_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of ogre. Gene sequence location is X:6867648..6885351.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	ogre: optic ganglia-reduced (J.C. Hall) Original allele (ogre1) recovered on the basis of simple lethality (Niklas and Cline, 1983); viable mutant (ogre2) isolated with respect to inability of adults to orient to vertical line of black-white contrast (Lipshitz and Kankel, 1985); optic lobes generally disorganized, as seen in adults expressing the viable allele, or in late pupae/pharate adults expressing a lethal allele; such lethals (all except ogre2) cause the behavioral and anatomical abnormalities just noted when heterozygous with viable allele; viability associated with one of these heteroallelic types, i.e., ogre1/ogre2 is poor, especially when reared at 18C (vs 29C); temperature shift experiments using this combination implies gene action in late larval stage; hemizygosity for lethal alleles causes development to cease in late larval-pupal stages, when parts of CNS appear abnormal (e.g., holes in sections of brain and thoracic ganglia, with severe defects appearing in the optic lobe formation centers); holes in CNS are also seen in "escapers", e.g., rare adults hemizygous for alleles other than ogre2, or heterozygous for ogre1 and ogre2; mosaic analysis suggests that CNS defects are due to action of this gene in those developing tissues (Lipshsitz and Kankel, 1985).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Transcripts ogre-RE Polypeptides ogre-PE Clones 11314 214403.14 GH10669
FB2012_01	Sequence features BKN25730 HFA18809
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 6E4-6E4   Limits computationally determined from genome sequence between P{EP}EP1338 and P{EP}inx7EP1641
Experimentally Determined Cytological Location
Cytogenetic map Notes References 6E2-6E4   (determined by in situ hybridisation)   (Watanabe and Kankel, 1990)
Experimentally Determined Recombination Data
Location	1-18.8 (Nicklas and Cline, 1983, )
Left of (cM)	stout (Nicklas and Cline, 1983) l(1)6Ed (Nicklas and Cline, 1983, Watanabe and Kankel, 1990)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\ogre for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.42
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) ogre-RA FBtr0071036  NM_080085   2176   362 ogre-RB FBtr0071037  NM_167101   1802   362 ogre-RC FBtr0309873     2163   362 ogre-RD FBtr0309874     2794   362 ogre-RE FBtr0309875     1689   362
Additional Transcript Data & Comments
Reported size (kB)	2.9 (northern blot) (Watanabe and Kankel, 1990)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein ogre-PA   FBpp0070995   42.6   362   9.08     NP_524824   AAF46225 ogre-PB   FBpp0070996   42.6   362   9.08     NP_727147   AAF46226 ogre-PC   FBpp0301607   42.6   362   9.08       ogre-PD   FBpp0301608   42.6   362   9.08       ogre-PE   FBpp0301609   42.6   362   9.08
Additional Polypeptide Data & Comments
Reported size (kDa)	362 (aa); 43 (kD) (Watanabe and Kankel, 1990)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Innexin (IPR000990)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA568069   AE014298 AAF46225   AE014298 AAF46226   AI064671   AI106743   AI114019   AI257257   AI257464   AW941989   BF502962   BI163114   BI163249   BI163501   BI165337   BI167162   BI168282   BI168381   BI168508   BI171286   BI171537   BI228267   BI228608   BI232171   BI232474   BI235109   BI243342   BI357654   BI358058   BI365556   BI367877   BI372217   BI373612   BI373990   BI374813   BI375321   BI483875   BI486113   BI566263   BI576323   BI577893   BI578289   BI583096   BP547698   BT004911 AAO49164   CO178644   CO182593   CO190142   CO193932   CO262962   CO263899   CO267770   CO270754   CO271175   CO272042   CO272328   CO272447   CO277908   CO278105   CO280395   CO282090   CO282770   CO282891   CO284697   CO289501   CO290370   CO291440   CO294772   CO295368   CO296967   CO298546   CO298652   CO298784   CO300425   CO300798   CO301589   CO304038   CO304051   CO304755   CO305261   CO306318   CO308433   CO311713   CO319265   CO321378   CO323485   CO323539   CO325811   CO325894   CO326344   CO330841   CO333928   CO339736   CO340964   CO343349   EC062150   EC062479   EC064792   EC065830   EC071353   EC071792   EC071998   EC072301   EC073276   EC074495   EC077157   EC078345   EC082054   EC082660   EC083259   EC083808   EC085466   EC086096   EC086880   EC089205   EC089694   EC089773   EC091165   EC195842   EC197326   EC199702   EC201809   EC202449   EC203314   EC204404   EC205427   EC206928   EC208121   EC208969   EC210340   EC215046   EC215685   EC222125   EC224250   EC232349   EC233103   EC233818   EC234086   EC239050   EC239051   EC240742   EC242506   EC245409   EC245804   EC247991   EC252128   EC257594   EC257675   EC257901   EC257911   EC260579   S77931   X61180 CAA43486
UniProtKB/Swiss-Prot	P27716
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 5   embryonic cortex   (Curtin et al., 1999) embryonic stage 8   cephalic furrow   (Curtin et al., 1999) germ band   (Curtin et al., 1999) embryonic stage 16 -- 17   embryonic/larval epidermis | segmentally repeated   (Curtin et al., 1999) embryonic/larval proventriculus   (Curtin et al., 1999) embryonic/larval foregut   (Curtin et al., 1999) embryonic/larval hindgut   (Curtin et al., 1999) adult stage   lamina   (Curtin et al., 1999)
Additional Descriptive Data
	ogre transcripts are detected in embryonic, early larval and late larval RNA on northern blots. Other stages were not tested. (Watanabe and Kankel, 1990) 2.9kb ogre transcript levels are reduced in the ogre1 mutant. (Watanabe and Kankel, 1990) Expression is almost identical to that of inx2 transcript. (Curtin et al., 1999)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
	ogre protein is found in optic formation centers and giant neuroblasts in third instar larvae. (Watanabe and Kankel, 1990)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0004646    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0004646 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0004646 expression level Developmental Stage   Expression Level embryo 00-02hr    576 embryo 02-04hr    5966 embryo 04-06hr    20794 embryo 06-08hr    21303 embryo 08-10hr    21959 embryo 10-12hr    17040 embryo 12-14hr    17535 embryo 14-16hr    9139 embryo 16-18hr    5385 embryo 18-20hr    4087 embryo 20-22hr    2619 embryo 22-24hr    3197 larva L1    2925 larva L2    3389 larva L3 12hr old    2403 larva L3 puffstage 1-2    2633 larva L3 puffstage 3-6    4411 larva L3 puffstage 7-9    7351 white prepupae new    10340 white prepupae 12hr    5085 white prepupae 24hr    9280 pupae 2d postWPP    7074 pupae 3d postWPP    7942 pupae 4d postWPP    3557 adult male 01day    2839 adult male 05day    2113 adult male 30day    1872 adult female 01day    3104 adult female 05day    2586 adult female 30day    2243 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (576) embryo 02-04hr  (5966) embryo 04-06hr  (20794) embryo 06-08hr  (21303) embryo 08-10hr  (21959) embryo 10-12hr  (17040) embryo 12-14hr  (17535) embryo 14-16hr  (9139) embryo 16-18hr  (5385) embryo 18-20hr  (4087) embryo 20-22hr  (2619) embryo 22-24hr  (3197) larva L1  (2925) larva L2  (3389) larva L3 12hr old  (2403) larva L3 puffstage 1-2  (2633) larva L3 puffstage 3-6  (4411) larva L3 puffstage 7-9  (7351) white prepupae new  (10340) white prepupae 12hr  (5085) white prepupae 24hr  (9280) pupae 2d postWPP  (7074) pupae 3d postWPP  (7942) pupae 4d postWPP  (3557) adult male 01day  (2839) adult male 05day  (2113) adult male 30day  (1872) adult female 01day  (3104) adult female 05day  (2586) adult female 30day  (2243) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    576 embryo 02-04hr  (5966) embryo 04-06hr  (20794) embryo 06-08hr  (21303) embryo 08-10hr  (21959) embryo 10-12hr  (17040) embryo 12-14hr  (17535) embryo 14-16hr  (9139) embryo 16-18hr  (5385) embryo 18-20hr  (4087) embryo 20-22hr  (2619) embryo 22-24hr  (3197) larva L1  (2925) larva L2  (3389) larva L3 12hr old  (2403) larva L3 puffstage 1-2  (2633) larva L3 puffstage 3-6  (4411) larva L3 puffstage 7-9  (7351) white prepupae new  (10340) white prepupae 12hr  (5085) white prepupae 24hr  (9280) pupae 2d postWPP  (7074) pupae 3d postWPP  (7942) pupae 4d postWPP  (3557) adult male 01day  (2839) adult male 05day  (2113) adult male 30day  (1872) adult female 01day  (3104) adult female 05day  (2586) adult female 30day  (2243) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    576 embryo 02-04hr    5966 embryo 04-06hr  (20794) embryo 06-08hr  (21303) embryo 08-10hr  (21959) embryo 10-12hr  (17040) embryo 12-14hr  (17535) embryo 14-16hr    9139 embryo 16-18hr    5385 embryo 18-20hr    4087 embryo 20-22hr    2619 embryo 22-24hr    3197 larva L1    2925 larva L2    3389 larva L3 12hr old    2403 larva L3 puffstage 1-2    2633 larva L3 puffstage 3-6    4411 larva L3 puffstage 7-9    7351 white prepupae new  10340 white prepupae 12hr    5085 white prepupae 24hr    9280 pupae 2d postWPP    7074 pupae 3d postWPP    7942 pupae 4d postWPP    3557 adult male 01day    2839 adult male 05day    2113 adult male 30day    1872 adult female 01day    3104 adult female 05day    2586 adult female 30day    2243 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    576 embryo 02-04hr    5966 embryo 04-06hr    20794 embryo 06-08hr    21303 embryo 08-10hr    21959 embryo 10-12hr    17040 embryo 12-14hr    17535 embryo 14-16hr    9139 embryo 16-18hr    5385 embryo 18-20hr    4087 embryo 20-22hr    2619 embryo 22-24hr    3197 larva L1    2925 larva L2    3389 larva L3 12hr old    2403 larva L3 puffstage 1-2    2633 larva L3 puffstage 3-6    4411 larva L3 puffstage 7-9    7351 white prepupae new    10340 white prepupae 12hr    5085 white prepupae 24hr    9280 pupae 2d postWPP    7074 pupae 3d postWPP    7942 pupae 4d postWPP    3557 adult male 01day    2839 adult male 05day    2113 adult male 30day    1872 adult female 01day    3104 adult female 05day    2586 adult female 30day    2243 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0004646 expression level Developmental Stage   Expression Level embryo 00-02hr    576 embryo 02-04hr    5966 embryo 04-06hr    20794 embryo 06-08hr    21303 embryo 08-10hr    21959 embryo 10-12hr    17040 embryo 12-14hr    17535 embryo 14-16hr    9139 embryo 16-18hr    5385 embryo 18-20hr    4087 embryo 20-22hr    2619 embryo 22-24hr    3197 larva L1    2925 larva L2    3389 larva L3 12hr old    2403 larva L3 puffstage 1-2    2633 larva L3 puffstage 3-6    4411 larva L3 puffstage 7-9    7351 white prepupae new    10340 white prepupae 12hr    5085 white prepupae 24hr    9280 pupae 2d postWPP    7074 pupae 3d postWPP    7942 pupae 4d postWPP    3557 adult male 01day    2839 adult male 05day    2113 adult male 30day    1872 adult female 01day    3104 adult female 05day    2586 adult female 30day    2243 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (576) embryo 02-04hr  (5966) embryo 04-06hr  (20794) embryo 06-08hr  (21303) embryo 08-10hr  (21959) embryo 10-12hr  (17040) embryo 12-14hr  (17535) embryo 14-16hr  (9139) embryo 16-18hr  (5385) embryo 18-20hr  (4087) embryo 20-22hr  (2619) embryo 22-24hr  (3197) larva L1  (2925) larva L2  (3389) larva L3 12hr old  (2403) larva L3 puffstage 1-2  (2633) larva L3 puffstage 3-6  (4411) larva L3 puffstage 7-9  (7351) white prepupae new  (10340) white prepupae 12hr  (5085) white prepupae 24hr  (9280) pupae 2d postWPP  (7074) pupae 3d postWPP  (7942) pupae 4d postWPP  (3557) adult male 01day  (2839) adult male 05day  (2113) adult male 30day  (1872) adult female 01day  (3104) adult female 05day  (2586) adult female 30day  (2243) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    576 embryo 02-04hr  (5966) embryo 04-06hr  (20794) embryo 06-08hr  (21303) embryo 08-10hr  (21959) embryo 10-12hr  (17040) embryo 12-14hr  (17535) embryo 14-16hr  (9139) embryo 16-18hr  (5385) embryo 18-20hr  (4087) embryo 20-22hr  (2619) embryo 22-24hr  (3197) larva L1  (2925) larva L2  (3389) larva L3 12hr old  2403 larva L3 puffstage 1-2  (2633) larva L3 puffstage 3-6  (4411) larva L3 puffstage 7-9  (7351) white prepupae new  (10340) white prepupae 12hr  (5085) white prepupae 24hr  (9280) pupae 2d postWPP  (7074) pupae 3d postWPP  (7942) pupae 4d postWPP  (3557) adult male 01day  (2839) adult male 05day  2113 adult male 30day  1872 adult female 01day  (3104) adult female 05day  (2586) adult female 30day  2243 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    576 embryo 02-04hr    5966 embryo 04-06hr  (20794) embryo 06-08hr  (21303) embryo 08-10hr  (21959) embryo 10-12hr  17040 embryo 12-14hr  17535 embryo 14-16hr    9139 embryo 16-18hr    5385 embryo 18-20hr    4087 embryo 20-22hr    2619 embryo 22-24hr    3197 larva L1    2925 larva L2    3389 larva L3 12hr old    2403 larva L3 puffstage 1-2    2633 larva L3 puffstage 3-6    4411 larva L3 puffstage 7-9    7351 white prepupae new  10340 white prepupae 12hr    5085 white prepupae 24hr    9280 pupae 2d postWPP    7074 pupae 3d postWPP    7942 pupae 4d postWPP    3557 adult male 01day    2839 adult male 05day    2113 adult male 30day    1872 adult female 01day    3104 adult female 05day    2586 adult female 30day    2243 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    576 embryo 02-04hr    5966 embryo 04-06hr    20794 embryo 06-08hr    21303 embryo 08-10hr    21959 embryo 10-12hr    17040 embryo 12-14hr    17535 embryo 14-16hr    9139 embryo 16-18hr    5385 embryo 18-20hr    4087 embryo 20-22hr    2619 embryo 22-24hr    3197 larva L1    2925 larva L2    3389 larva L3 12hr old    2403 larva L3 puffstage 1-2    2633 larva L3 puffstage 3-6    4411 larva L3 puffstage 7-9    7351 white prepupae new    10340 white prepupae 12hr    5085 white prepupae 24hr    9280 pupae 2d postWPP    7074 pupae 3d postWPP    7942 pupae 4d postWPP    3557 adult male 01day    2839 adult male 05day    2113 adult male 30day    1872 adult female 01day    3104 adult female 05day    2586 adult female 30day    2243 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0004646    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0004646 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult fat body, larval trachea, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, larval/adult hindgut, adult heart, larval salivary gland, adult spermathecae, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0004646 expression level Tissue   Expression Level Larval Central Nervous System    900.5 Larval Midgut    28.1 Larval Hindgut    156.1 Larval Malpighian Tubules no informative data Larval Fat Body    79 Larval Salivary Gland    224.1 Larval Trachea    534.85 Larval Carcass    456.3 Adult Head    457.6 Adult Eye    415.375 Adult Brain    622.7 Adult Thoracic-Abdominal Ganglion    649.5 Adult Crop    329.3 Adult Midgut    57.9 Adult Hindgut    314.4 Adult Malpighian Tubules no informative data Adult Fat Body    504.2 Adult Salivary Gland no informative data Adult Heart    194.15 Adult VirginFemale Spermatheca    137.4 Adult InseminatedFemale Spermatheca    132.1 Adult Ovary    93.4 Adult Testis    93.3 Adult Male Accessory Gland    507.7 Adult Carcass    248.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (900.5) Larval Midgut    28.1 Larval Hindgut    156.1 Larval Malpighian Tubules no informative data Larval Fat Body    79 Larval Salivary Gland    224.1 Larval Trachea  534.85 Larval Carcass    456.3 Adult Head    457.6 Adult Eye    415.375 Adult Brain  (622.7) Adult Thoracic-Abdominal Ganglion  (649.5) Adult Crop    329.3 Adult Midgut    57.9 Adult Hindgut    314.4 Adult Malpighian Tubules no informative data Adult Fat Body  504.2 Adult Salivary Gland no informative data Adult Heart    194.15 Adult VirginFemale Spermatheca    137.4 Adult InseminatedFemale Spermatheca    132.1 Adult Ovary    93.4 Adult Testis    93.3 Adult Male Accessory Gland  507.7 Adult Carcass    248.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    900.5 Larval Midgut    28.1 Larval Hindgut    156.1 Larval Malpighian Tubules no informative data Larval Fat Body    79 Larval Salivary Gland    224.1 Larval Trachea    534.85 Larval Carcass    456.3 Adult Head    457.6 Adult Eye    415.375 Adult Brain    622.7 Adult Thoracic-Abdominal Ganglion    649.5 Adult Crop    329.3 Adult Midgut    57.9 Adult Hindgut    314.4 Adult Malpighian Tubules no informative data Adult Fat Body    504.2 Adult Salivary Gland no informative data Adult Heart    194.15 Adult VirginFemale Spermatheca    137.4 Adult InseminatedFemale Spermatheca    132.1 Adult Ovary    93.4 Adult Testis    93.3 Adult Male Accessory Gland    507.7 Adult Carcass    248.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    900.5 Larval Midgut    28.1 Larval Hindgut    156.1 Larval Malpighian Tubules no informative data Larval Fat Body    79 Larval Salivary Gland    224.1 Larval Trachea    534.85 Larval Carcass    456.3 Adult Head    457.6 Adult Eye    415.375 Adult Brain    622.7 Adult Thoracic-Abdominal Ganglion    649.5 Adult Crop    329.3 Adult Midgut    57.9 Adult Hindgut    314.4 Adult Malpighian Tubules no informative data Adult Fat Body    504.2 Adult Salivary Gland no informative data Adult Heart    194.15 Adult VirginFemale Spermatheca    137.4 Adult InseminatedFemale Spermatheca    132.1 Adult Ovary    93.4 Adult Testis    93.3 Adult Male Accessory Gland    507.7 Adult Carcass    248.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0004646 expression level Tissue   Expression Level Larval Central Nervous System    900.5 Larval Midgut    28.1 Larval Hindgut    156.1 Larval Malpighian Tubules no informative data Larval Fat Body    79 Larval Salivary Gland    224.1 Larval Trachea    534.85 Larval Carcass    456.3 Adult Head    457.6 Adult Eye    415.375 Adult Brain    622.7 Adult Thoracic-Abdominal Ganglion    649.5 Adult Crop    329.3 Adult Midgut    57.9 Adult Hindgut    314.4 Adult Malpighian Tubules no informative data Adult Fat Body    504.2 Adult Salivary Gland no informative data Adult Heart    194.15 Adult VirginFemale Spermatheca    137.4 Adult InseminatedFemale Spermatheca    132.1 Adult Ovary    93.4 Adult Testis    93.3 Adult Male Accessory Gland    507.7 Adult Carcass    248.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (900.5) Larval Midgut    28.1 Larval Hindgut    156.1 Larval Malpighian Tubules no informative data Larval Fat Body    79 Larval Salivary Gland    224.1 Larval Trachea  534.85 Larval Carcass    456.3 Adult Head    457.6 Adult Eye    415.375 Adult Brain  622.7 Adult Thoracic-Abdominal Ganglion  649.5 Adult Crop    329.3 Adult Midgut    57.9 Adult Hindgut    314.4 Adult Malpighian Tubules no informative data Adult Fat Body  504.2 Adult Salivary Gland no informative data Adult Heart    194.15 Adult VirginFemale Spermatheca    137.4 Adult InseminatedFemale Spermatheca    132.1 Adult Ovary    93.4 Adult Testis    93.3 Adult Male Accessory Gland  507.7 Adult Carcass    248.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    900.5 Larval Midgut    28.1 Larval Hindgut    156.1 Larval Malpighian Tubules no informative data Larval Fat Body    79 Larval Salivary Gland    224.1 Larval Trachea    534.85 Larval Carcass    456.3 Adult Head    457.6 Adult Eye    415.375 Adult Brain    622.7 Adult Thoracic-Abdominal Ganglion    649.5 Adult Crop    329.3 Adult Midgut    57.9 Adult Hindgut    314.4 Adult Malpighian Tubules no informative data Adult Fat Body    504.2 Adult Salivary Gland no informative data Adult Heart    194.15 Adult VirginFemale Spermatheca    137.4 Adult InseminatedFemale Spermatheca    132.1 Adult Ovary    93.4 Adult Testis    93.3 Adult Male Accessory Gland    507.7 Adult Carcass    248.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    900.5 Larval Midgut    28.1 Larval Hindgut    156.1 Larval Malpighian Tubules no informative data Larval Fat Body    79 Larval Salivary Gland    224.1 Larval Trachea    534.85 Larval Carcass    456.3 Adult Head    457.6 Adult Eye    415.375 Adult Brain    622.7 Adult Thoracic-Abdominal Ganglion    649.5 Adult Crop    329.3 Adult Midgut    57.9 Adult Hindgut    314.4 Adult Malpighian Tubules no informative data Adult Fat Body    504.2 Adult Salivary Gland no informative data Adult Heart    194.15 Adult VirginFemale Spermatheca    137.4 Adult InseminatedFemale Spermatheca    132.1 Adult Ovary    93.4 Adult Testis    93.3 Adult Male Accessory Gland    507.7 Adult Carcass    248.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules no informative data Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    457.6   NA  Eye    415.375   NA  Brain    622.7   900.5  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    649.5   NA  Crop    329.3   28.1  Midgut    57.9   156.1  Hindgut    314.4   no informative data  Malpighian Tubules    no informative data   79  Fat Body    504.2   224.1  Salivary Gland    no informative data   NA  Heart    194.15   534.85  Trachea    NA   NA  VirginFemale Spermatheca    137.4   NA  InseminatedFemale Spermatheca    132.1   NA  Ovary    93.4   NA  Testis    93.3   NA  Male Accessory Gland    507.7   456.3  Carcass    248.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_11
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004646 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3039-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for ogre Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele cell lethal | germline clone | larval stage ogre1 lethal ogre1 ogre3 ogre4 ogre5 ogreunspecified lethal | embryonic stage ogre5 lethal | larval stage | recessive ogre1 ogre3 ogre4 lethal | recessive ogre1 ogre5 lethal | recessive | heat sensitive ogre2 viable ogre2 ogref07788 viable, with Scer\GAL4pnr-MD237 ogreGD3264 Sterility Allele fertile ogref07788 Other Phenotypes Allele neurophysiology defective ogre2 neurophysiology defective | adult stage ogre2 wild-type ogre+t12.5 Phenotype manifest in Allele central nervous system ogre2 ogre3 ogre4 ogreunspecified lamina monopolar neuron ogre2 optic lobe ogre2 ogre3 ogre4 ogreunspecified photoreceptor cell ogre2
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of ogre Class Mutagen Stocks Known lesion ogre5-45fP 8 Yes ogref07788 piggyBac transposase 2 -- ogre1 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- ogre2 ethyl methanesulfonate 0 -- ogre3 ethyl nitrosourea 0 -- ogre4 ethyl nitrosourea 0 -- ogre5 spontaneous 0 Yes ogreunspecified 0 --
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of ogre Class Mutagen Stocks Known lesion ogreGD3264 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ogreJF02595 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ogreKK104770 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ogre+t12.5 in vitro construct - genomic fragment 0 Yes ogreScer\UAS.cCa in vitro construct - regulatory fusion 0 Yes ogreScer\UAS.ΔC.cCb in vitro construct - coding region fusion 0 Yes ogretCH322-155A19 in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)ct-J6 (Nicklas and Cline, 1983) Df(1)HA32 (Gong et al., 2004, Kankel et al., 1989) Df(1)ogre18-183 (Watanabe and Kankel, 1990) Df(1)Sxl-bt (Gong et al., 2004, Nicklas and Cline, 1983, Watanabe and Kankel, 1990)
Duplicated in	Dp(1;Y)ct+y+ (Nicklas and Cline, 1983)
Not disrupted in	Df(1)ct-J4 (Nicklas and Cline, 1983) Df(1)HA32 (Nicklas and Cline, 1983, Watanabe and Kankel, 1990) Df(1)RF19 (Nicklas and Cline, 1983) Df(1)Sp8A (Schalet, 1986) Df(1)Sxl-bt (Kankel et al., 1989) Df(1)Sxl-ra (Nicklas and Cline, 1983)
Not duplicated in	Dp(1;2)sn+72d (Nicklas and Cline, 1983)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3264} NA P{KK104770} NA P{TRiP.JF02595} NA P{UAS-ogre.C} NA P{UAS-ogreΔC} NA characterization construct P{4K12.5Xh} NA P{UAS-ogre::shakBo1-107:s98-172:o183-end} NA P{UAS-ogre::shakBo1-182:s173-241:o252-end} NA P{UAS-ogre::shakBo1-182:s173-end} NA P{UAS-ogre::shakBs1-97:o108-end} NA P{UAS-ogre::shakBs1-172:o183-end} NA PBac{CH322-155A19} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}ogref07788 NA insertion of enhancer trap P{lacW}ogre5-45fP No
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
phototransduction inferred from mutant phenotype (Curtin et al., 2002)
Cellular Component
CV term Evidence References
basolateral plasma membrane inferred from direct assay (Bohrmann and Zimmermann, 2008) gap junction inferred from direct assay (Bohrmann and Zimmermann, 2008) plasma membrane inferred from direct assay (Khanna et al., 2010)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
nervous system development non-traceable author statement (Swiss-Prot Project Members, 1992.8.1) visual behavior inferred from sequence or structural similarity (Phelan et al., 1998)
Cellular Component
CV term Evidence References
gap junction non-traceable author statement (Swiss-Prot Project Members, 1992.8.1) integral to membrane non-traceable author statement (Swiss-Prot Project Members, 1992.8.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions ogre allele Gene References ogre2 ogre::shakB (Curtin et al., 2002) unspecified shakB (Curtin et al., 2002)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 69639 DroID - A comprehensive database of gene and protein interactions. • FBgn0004646 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45382
Orthologs
Genome-wide drosophilid orthologs	Dana\GF20330 Dere\GG17645 Dgri\GH24274 Dmoj\GI21582 Dper\GL26811 Dpse\GA26182 Dsec\GM17487 Dsim\GD16171 Dvir\GJ15803 Dwil\GK25296 Dyak\GE17553
Curated drosophilid orthologs	Dpse\GA15810   Dsim\ogre (Swanson et al., 2001)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL014846-PA Aedes aegypti (mosquito) AGAP001476-PA Anopheles gambiae (mosquito) XP_001121323.1 Apis mellifera (honey bee) XP_001946431.1 Acyrthosiphon pisum (pea aphid) 219379 Daphnia pulex (daphnia) XP_001603984.1 Nasonia vitripennis (wasp) PHUM006854-PA Pediculus humanus (human body louse) PP02802 Pristionchus pacificus (nematode) PP14178 Pristionchus pacificus (nematode) PP24708 Pristionchus pacificus (nematode) XP_968503.1 Tribolium castaneum (red flour beetle) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV17062 LH12526 ISCW010070 FBgn0235012 FBgn0227255 FBgn0202990 FBgn0187801 FBgn0172396 JGI_V11_219379 FBgn0247558 FBgn0164392 FBgn0144312 FBgn0131730 FBgn0109867 FBgn0097337 ACYPI004359 ACYPI004128 AGAP001476 AAEL014846 PB21400 PHUM124400 PHUM403140 GLEAN_11064
Stocks & Reagents
Stocks Listed in FlyBase ( 13 )
Bloomington	19110 w1118 PBac{WH}ogref07788 27283 y1 v1; P{TRiP.JF02595}attP2 3709 y1 P{lacW}elav5-45fD w* P{lacW}ogre5-45fP P{lacW}3-52d P{lacW}3-76a 16 C(1)RM, y1 P{lacW}elav5-45fD w* P{lacW}ogre5-45fP P{lacW}3-52d P{lacW}3-76a/0/C(1;Y)13, v1 f1
Harvard	- PBac{WH}ogref07788
Kyoto	107188 y1 P{lacW}elav5-45fD w* P{lacW}ogre5-45fP P{lacW}3-52d P{lacW}3-76a 107179 C(1)RM, y1 P{lacW}elav5-45fD w* P{lacW}ogre5-45fP P{lacW}3-52d P{lacW}3-76a/+ 107190 C(1)RM, y1 P{lacW}elav5-45fD w* P{lacW}ogre5-45fP P{lacW}3-52d P{lacW}3-76a/w1118/Y 105677 C(1)RM, y1 P{lacW}elav5-45fD w* P{lacW}ogre5-45fP P{lacW}3-52d P{lacW}3-76a/0/C(1;Y)13, v1 f1 107189 0/C(1;Y)*, y1 P{lacW}elav5-45fD w* P{lacW}ogre5-45fP P{lacW}3-52d P{lacW}3-76a y+/C(1)RM, y1 pn1
VDRC	v103816 P{KK104770}VIE-260B v7136 w1118; P{GD3264}v7136
	More stocks available...
Genomic Clones ( 2 )
	BACR04D11 BACR17C09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 143 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	HL01248
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH02894 GH07675 GH10669 LP05567 LP05842 RE02437 RE02601 RE02918 RE05210 RE07484 RE08883 RE09095 RE09265 RE13024 RE13339 RE25749 RE26203 RE28189 RE28548 RE30919 RE40950 RE44184 RE44725 RE50913 RE53742 RE59122 RE60950 RE61480 RE62502 RE63096 RE66834 RE69487 RE71656 RE72140 RH21544 RH32861 RH35464
Other clones	7798 8149 8502 11314 16857 28736 29828 34463 38718 39793 40160 44302 45542 45886 47255 53822 54323 55110 61948 63906 73651 76454 81793 99192 101306 104304 122828 125819 144266 154522 157173 166604 173062 173064 173167 175599 214211.15 214247.3 214341.6 214403.14 214447.12 214505.5 282503 AT18834 CK01.23A.F9 CK01.58A.E6 CK01.72A.E10 CK01.98A.F9 CK01.103C.A6 CK01.117D.D11 CK01.125D.C11 CK01.128C.D5 CK01.130C.E2 CK01.167B.D1 EC23081 EC37112 EK046751 EK057249 EK071207 EK073809 EK079335 EK086935 EK100137 EK102210 EK105714 EK106745 EK107217 EK127702 EK128833 EK136817 EK151813 EK153949 EK159516 EK161161 EK161715 EK166558 EK173228 EK173428 EK173847 EK178155 EK179427 EK181514 EK185553 EK190606 EK190755 EK207631 EK209604 EK215550 EK226002 EK243508 EK243530 EK246049 EK247811 EK250753 EK258139 EK277517 EK296303 EK308357 EP02554 EP02853 EP03715 EP11639 EP16627 EP22434 FGH119G06
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004646 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45382
Antibody Information
	polyclonal (Watanabe and Kankel, 1990, Bohrmann and Zimmermann, 2008)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: ogre CG3039 (Bayraktaroglu, 2000.4.13)
Additional comments
Other Comments
	Domain-swapping experiments for shakB and ogre indicate that residues crucial for innexin function are found in the intracellular loop and well as a short stretch N-terminal to the second transmembrane domain. (Curtin et al., 2002) Electroretinograms for molecular chimeras and rescue constructs for shakB and ogre indicate that innexins are not interchangeable in their roles of promoting normal neural development in flies. (Curtin et al., 2002) ogre RNA and protein expression during development has been studied. (Watanabe and Kankel, 1992) Genetic and developmental studies have indicated that the wild type function of ogre is crucial for and specific to postembryonic neurogenesis. (Watanabe and Kankel, 1990) The ogre locus has been cloned, and the expression of ogre RNA during development has been analysed. (Kankel et al., 1989) Developmental analysis has shown that effect of mutations at the locus are restricted to the developing and adult CNS. The time of ogre gene action is during the early and late larval period. (Lipshitz and Kankel, 1985) Original allele (ogre1) recovered on the basis of simple lethality (Niklas and Cline, 1983); viable mutant (ogre2) isolated with respect to inability of adults to orient to vertical line of black-white contrast (Lipshitz and Kankel, 1985); optic lobes generally disorganized, as seen in adults expressing the viable allele, or in late pupae/pharate adults expressing a lethal allele; such lethals (all except ogre2) cause the behavioral and anatomical abnormalities just noted when heterozygous with viable allele; viability associated with one of these heteroallelic types, i.e., ogre1/ogre2 is poor, especially when reared at 18oC (vs 29oC); temperature shift experiments using this combination implies gene action in late larval stage; hemizygosity for lethal alleles causes development to cease in late larval-pupal stages, when parts of CNS appear abnormal (e.g., holes in sections of brain and thoracic ganglia, with severe defects appearing in the optic lobe formation centers); holes in CNS are also seen in 'escapers', e.g., rare adults hemizygous for alleles other than ogre2, or heterozygous for ogre1 and ogre2; mosaic analysis suggests that CNS defects are due to action of this gene in those developing tissues (Lipshitz and Kankel, 1985).
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080085 NM_167101 RefSeq (Proteins) • NP_524824 NP_727147 DDBJ / EMBL / GenBank • AA568069 AAF46225 AAF46226 AAO49164 AW941989 BT004911 CAA43486 S77931 X61180 Entrez Gene - A searchable database of RefSeq genes. • 45382 UniProtKB/Swiss-Prot • P27716
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Innexin (IPR000990)
Linkouts
	BioGRID - A database of protein and genetic interactions • 69639 DroID - A comprehensive database of gene and protein interactions. • FBgn0004646 DRSC - Results from RNAi screens. • FBgn0004646 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004646 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3039-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004646 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45382 InParanoid A subset of ortholog calls from InParanoid. • AAEL014846-PA Aedes aegypti (mosquito) AGAP001476-PA Anopheles gambiae (mosquito) XP_001121323.1 Apis mellifera (honey bee) XP_001946431.1 Acyrthosiphon pisum (pea aphid) 219379 Daphnia pulex (daphnia) XP_001603984.1 Nasonia vitripennis (wasp) PHUM006854-PA Pediculus humanus (human body louse) PP02802 Pristionchus pacificus (nematode) PP14178 Pristionchus pacificus (nematode) PP24708 Pristionchus pacificus (nematode) XP_968503.1 Tribolium castaneum (red flour beetle) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45382 modMine - Data generated by the modENCODE project. • FBgn0004646 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV17062 LH12526 ISCW010070 FBgn0235012 FBgn0227255 FBgn0202990 FBgn0187801 FBgn0172396 JGI_V11_219379 FBgn0247558 FBgn0164392 FBgn0144312 FBgn0131730 FBgn0109867 FBgn0097337 ACYPI004359 ACYPI004128 AGAP001476 AAEL014846 PB21400 PHUM124400 PHUM403140 GLEAN_11064
Synonyms & Secondary IDs ( 18 )
Reported As
Symbol Synonym	cb-8   CB8   CG3039 (Keleman et al., 2009.8.5, Khanna et al., 2010) Dm-inx1 (Davies and Curtin, 1999.9.30) inx-1 (Chiusano et al., 2005) inx1 (Davies, 1999.9.16, Wu et al., 2011) Inx1 (Davies, 1999.9.16, Bohrmann and Zimmermann, 2008) jnL3 (Nicklas and Cline, 1983) l(1)6Ec   l(1)jnL3   l(1)ogre (Littleton and Ganetzky, 2000, Paricio, 1995.9.26, Paricio et al., 1995, Crompton et al., 1993, Meinertzhagen and Hanson, 1993, Kankel et al., 1989, Watanabe and Kankel, 1992, Watanabe and Kankel, 1990, Lipshitz and Kankel, 1985, ) ogre (Curtin et al., 2002, Lott et al., 2011, Lindsley and Zimm, 1992, Younger, 2009.7.13, Perkins et al., 2009.8.10, Venken et al., 2009, Quijano et al., 2008)
Name Synonym	contrast-blind-8   Innexin 1 (Bauer et al., 2004) innexin 1 (Bohrmann and Zimmermann, 2008) optic ganglia-reduced (Lindsley and Zimm, 1992) optic ganglion reduced   Optic ganglion reduced (Khanna et al., 2010)
Secondary FlyBase IDs
	FBgn0000265 FBgn0002988 FBgn0029926
References ( 67 )
Generate a list of	All references relating to this gene ( 67 )
List References by type	Research paper  ( 29 ) Supplementary material  ( 6 ) Review  ( 6 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 6 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Book  ( 1 ) Letter  ( 3 ) Protein sequence record  ( 1 ) Computer file  ( 2 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 3 )
	Lott et al., 2011, PLoS Biol. 9(2): e1000590 Noncanonical Compensation of Zygotic X Transcription in Early Drosophila melanogaster Development Revealed through Single-Embryo RNA-Seq. [FBrf0213135] Wu et al., 2011, Curr. Biol. 21(10): 848--854 Heterotypic Gap Junctions between Two Neurons in the Drosophila Brain Are Critical for Memory. [FBrf0213804] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...