FlyBase Gene Report: Dmel\svr

General Information

Symbol

Dmel\svr

Species

D. melanogaster

Name

silver

Annotation Symbol

CG4122

Feature Type

protein_coding_gene

FlyBase ID

FBgn0004648

Gene Model Status

Current

Stock Availability

28 publicly available

Gene Summary

Required for the proper melanization and sclerotization of the cuticle. (UniProt, P42787)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Red Book
Interactive Fly

Also Known As

EG:171D11.3 , CPD, slv

Key Links

Genomic Location

Cytogenetic map

1B5-1B7

Sequence location

X:496,446..509,072 [+]

Recombination map

1-0

RefSeq locus

NC_004354 REGION:496446..509072

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

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Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (14 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables carboxypeptidase activity

inferred from mutant phenotype

(Pauls et al., 2019, Sidyelyeva et al., 2010)

inferred from direct assay

(Sidyelyeva et al., 2006)

enables metallocarboxypeptidase activity

inferred from direct assay

(Sidyelyeva and Fricker, 2002)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables metallocarboxypeptidase activity

inferred from biological aspect of ancestor with PANTHER:PTN000164240

(assigned by GO_Central )

(Gaudet et al., 2011)

enables zinc ion binding

inferred from electronic annotation with InterPro:IPR000834

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (7 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in imaginal disc-derived wing morphogenesis

inferred from mutant phenotype

(Sidyelyeva et al., 2006)

involved_in long-term memory

inferred from mutant phenotype

(Sidyelyeva et al., 2010)

involved_in negative regulation of protein phosphorylation

inferred from mutant phenotype

(assigned by UniProt )

(Dopie et al., 2015)

involved_in neuropeptide processing

inferred from mutant phenotype

(Pauls et al., 2019)

involved_in positive regulation of actin filament polymerization

inferred from mutant phenotype

(assigned by UniProt )

(Dopie et al., 2015)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in peptide metabolic process

inferred from biological aspect of ancestor with PANTHER:PTN000164240

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in protein processing

inferred from biological aspect of ancestor with PANTHER:PTN000164240

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

located_in endomembrane system

inferred from high throughput direct assay

(Tan et al., 2009)

located_in extracellular region

inferred from high throughput direct assay

(Karlsson et al., 2004)

located_in perinuclear region of cytoplasm

inferred from direct assay

(Sidyelyeva et al., 2010)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in extracellular space

inferred from biological aspect of ancestor with PANTHER:PTN000164240

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

M14 METALLOCARBOXYPEPTIDASES

Protein Family (UniProt)

Belongs to the peptidase M14 family. (P42787)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

M14 METALLOCARBOXYPEPTIDASES -: M14 metallopeptidases belong to MEROPS family M14. They hydrolyse single, C-terminal amino acids from polypeptide chains and have a recognition site for the free C-terminal carboxyl group, which is a key determinant of specificity. Their functions are numerous and diverse, and include digestion of food and processing of bioactive peptides. (Adapted from FBrf0239469.)

Protein Function (UniProtKB)

Required for the proper melanization and sclerotization of the cuticle.

(UniProt, P42787)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

svr: silver

Color of legs, wings, veins, and integument pale and silvery. Bristles and trident pattern on thorax dark. Tyrosinase formed in adult (Horowitz). Wings of all males and some females pointed. Viability fair. Larval mouth parts normal in color. RK2.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\svr for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.50

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

svr-RB

FBtr0070081

NM_080293

5890

1406

svr-RD

FBtr0070084

NM_206599

5904

1404

svr-RE

FBtr0070085

NM_206598

3144

433

svr-RF

FBtr0070086

NM_206597

3130

435

svr-RG

FBtr0070087

NM_206596

5828

1439

svr-RH

FBtr0290016

NM_166846

5842

1437

svr-RI

FBtr0290017

NM_001144669

5267

1292

svr-RJ

FBtr0340146

NM_001297813

3092

433

svr-RL

FBtr0344737

NM_001297814

2851

435

svr-RM

FBtr0344738

NM_176679

5611

1406

svr-RN

FBtr0344739

NM_001297815

4986

1439

Additional Transcript Data and Comments

Reported size (kB)

6-7, 3.9, 3.3, 2.5, 1.5 (compiled cDNA)

(Settle et al., 1995)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

svr-PB

FBpp0070080

158.8

1406

6.74

NP_525032

AAF45514

svr-PD

FBpp0089123

158.5

1404

6.42

NP_996322

AAS65237

svr-PE

FBpp0089124

48.3

433

4.96

NP_996321

AAS65238

svr-PF

FBpp0089125

48.6

435

6.27

NP_996320

AAS65240

svr-PG

FBpp0089126

162.7

1439

6.31

NP_996319

AAS65239

svr-PH

FBpp0288455

162.4

1437

5.97

NP_726675

AAF45515

svr-PI

FBpp0288456

146.3

1292

6.27

NP_001138141

ACL82874

svr-PJ

FBpp0309132

48.3

433

4.96

NP_001284742

AHN59213

svr-PL

FBpp0311069

48.6

435

6.27

NP_001284743

AHN59214

svr-PM

FBpp0311070

158.8

1406

6.74

NP_788852

AAO41630

svr-PN

FBpp0311071

162.7

1439

6.31

NP_001284744

AHN59215

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1406 aa isoforms: svr-PB, svr-PM

435 aa isoforms: svr-PF, svr-PL

433 aa isoforms: svr-PE, svr-PJ

1439 aa isoforms: svr-PG, svr-PN

Additional Polypeptide Data and Comments

Reported size (kDa)

1119 (aa); 126.5 (kD predicted)

(Settle et al., 1995)

Comments

External Data

Domain

There are 3 carboxypeptidase-like domains. Only the first two domains seem to have kept a catalytic activity.

(UniProt, P42787)

Crossreferences

InterPro - A database of protein families, domains and functional sites

MEROPS - An information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them.

M14.011

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\svr using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

svr_1
svr_2

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Settle et al., 1995)

Additional Descriptive Data

svr transcripts are detected in Northern blots of embryonic RNA.

(Settle et al., 1995)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in endomembrane system

inferred from high throughput direct assay

(Tan et al., 2009)

located_in extracellular region

inferred from high throughput direct assay

(Karlsson et al., 2004)

located_in perinuclear region of cytoplasm

inferred from direct assay

(Sidyelyeva et al., 2010)

Expression Deduced from Reporters

Reporter: P{GawB}svr^PG33

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 9 -- 17

plasmatocyte

(Waltzer et al., 2003)

larval stage

Kenyon cell

(Pauls et al., 2019)

neuron | subset of embryonic/larval central nervous system

(Pauls et al., 2019)

embryonic/larval corpus cardiacum

(Pauls et al., 2019)

ring gland

(Pauls et al., 2019)

adult stage

neuron | subset of adult central nervous system

(Pauls et al., 2019)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\svr in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\svr

View exonic expression by tissue for Dmel\svr

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0004648

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG4122-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4122

Flygut - An atlas of the Drosophila adult midgut

FBgn0004648

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 65 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 15 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of svr

Transgenic constructs containing regulatory region of svr

Aberrations (Deficiencies and Duplications) ( 45 )

Inferred from experimentation ( 45 )

Gene duplicated in

Gene not disrupted in

Df(1)260-1

(Sutton, 1943)

Df(1)403

(Kramers et al., 1991)

Df(1)A94

(Kramers et al., 1991)

Df(1)cin-arth

(Kramers et al., 1991, Kramers et al., 1983)

Df(1)MMG2

(Green, 1982)

Df(1)MMG4

(Green, 1982)

Df(1)S39

(Kramers et al., 1991)

(Schalet, 1986)

(Schalet, 1986)

(Schalet, 1986)

(Schalet, 1986)

(Kramers et al., 1991)

(Sutton, 1943)

(Sutton, 1943)

(Sutton, 1943)

(Sutton, 1943)

(Sutton, 1943)

(Sutton, 1943)

(Sutton, 1943)

(Sutton, 1943)

(Sutton, 1943)

(Sutton, 1943)

Gene not duplicated in

Dp(1;3)sta

(Kramers et al., 1991)

Gene disrupted in

(Ryder, 2004.4.26)

(Green, 1982)

(Park and Yamamoto, 1993, Kramers et al., 1991, Kramers et al., 1983, Sutton, 1943, California Institute of Technology, 1940)

Df(1)y74k24.1

(Kramers et al., 1991, Kramers et al., 1983)

Df(1)y^-(1)

(Settle et al., 1995)

Df(1)y^-(2)

(Settle et al., 1995)

Inferred from location ( 0 )

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

lethal - all die before end of larval stage

svr⁸

lethal - all die before end of larval stage | recessive

partially lethal

partially lethal - majority die | recessive

svr^dwp

viable

viable | recessive

svr^Poi

Sterility

Allele

fertile

svr^dwp

semi-sterile

svr^cc-y

Other Phenotypes

Allele

abnormal body color

abnormal body color | recessive

svr¹

abnormal cold stress response | recessive

abnormal memory | recessive

electrophoretic variant

some die during larval stage

svr⁸

some die during larval stage | recessive

visible

visible (with svr¹)

svr^PG33

visible (with svr^PG33)

visible (with svr^poi)

svr^PG33

visible | recessive

Phenotype manifest in

Allele

anterior crossvein

microchaeta

svr^poi-dish

posterior crossvein

wing

wing blade

wing blade (with svr¹)

svr^PG33

wing blade (with svr^PG33)

wing blade (with svr^poi)

svr^PG33

wing vein (with svr¹)

svr^PG33

wing vein (with svr^PG33)

wing vein (with svr^poi)

svr^PG33

wing vein L1

svr^poi

wing vein L2

svr^poi

wing vein L3

wing vein L4

wing vein L5

svr¹

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (8)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\CPD

12 of 15

Yes

Hsap\CPE

4 of 15

Yes

Hsap\CPM

3 of 15

Hsap\CPN1

3 of 15

Yes

Hsap\AEBP1

2 of 15

Yes

Hsap\CPXM1

2 of 15

Yes

Hsap\CPXM2

2 of 15

Yes

Hsap\CPZ

2 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (8)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Cpd

12 of 15

Yes

Mmus\Cpe

4 of 15

Yes

Mmus\Cpm

3 of 15

Mmus\Cpn1

3 of 15

Yes

Mmus\Aebp1

2 of 15

Yes

Mmus\Cpxm1

2 of 15

Yes

Mmus\Cpxm2

2 of 15

Yes

Mmus\Cpz

2 of 15

Yes

Rattus norvegicus (Norway rat) (7)

Rnor\Cpd

11 of 13

Yes

Rnor\Aebp1

2 of 13

Yes

Rnor\Cpe

2 of 13

Yes

Rnor\Cpn1

2 of 13

Yes

Rnor\Cpxm1

2 of 13

Yes

Rnor\Cpz

2 of 13

Yes

Rnor\Cpm

1 of 13

Xenopus tropicalis (Western clawed frog) (8)

Xtro\cpd

2 of 12

Yes

Xtro\cpd

2 of 12

Yes

Xtro\cpm

2 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (8)

Drer\cpda

12 of 15

Yes

Drer\cpdb

6 of 15

Yes

Drer\cpe

4 of 15

Yes

Drer\cpm

2 of 15

Drer\cpn1

2 of 15

Yes

Drer\aebp1

1 of 15

Drer\cpxm1a

1 of 15

Drer\si:ch1073-459j12.1

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (4)

Cele\cpd-1

6 of 15

Yes

Cele\cpd-2

6 of 15

Yes

Cele\egl-21

2 of 15

Cele\suro-1

1 of 15

Arabidopsis thaliana (thale-cress) (1)

Atha\SOL1

5 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091900KK )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA29134

Drosophila persimilis

Dper\GL20387

Drosophila willistoni

Dwil\GK16509

Drosophila virilis

Dvir\GJ14862

Drosophila mojavensis

Dmoj\GI15159

Drosophila grimshawi

Dgri\GH24780

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500DU )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17009412

Musca domestica

House fly

Mdoa\17018308

Glossina morsitans

Tsetse fly

Gmor\GMOY009834

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_04774

Mayetiola destructor

Hessian fly

Mdes\Mdes006689

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL017499

Anopheles darlingi

American malaria mosquito

Adar\ADAC001270

Anopheles gambiae

Malaria mosquito

Agam\AGAP002414

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ009464

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W05DI )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA005320

Bombyx mori

Silkmoth

Bmor\BGIBMGA012807

Danaus plexippus

Monarch butterfly

Dple\DPOGS207768-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS206855-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL006139

Heliconius melpomene

Postman butterfly

Hmel\HMEL017562

Apis florea

Little honeybee

Aflo\2327959572

Apis florea

Little honeybee

Aflo\4367335540

Apis mellifera

Western honey bee

Amel\GB41454

Apis mellifera

Western honey bee

Amel\GB43684

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP20270

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP22695

Bombus terrestris

Buff-tailed bumblebee

Bter\15214714

Bombus terrestris

Buff-tailed bumblebee

Bter\15214563

Linepithema humile

Argentine ant

Lhum\LH18456

Linepithema humile

Argentine ant

Lhum\LH13835

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:00139f

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000efd

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG012195

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_08368

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_07016

Tribolium castaneum

Red flour beetle

Tcas\TC012672

Tribolium castaneum

Red flour beetle

Tcas\GLEAN_15532

Tribolium castaneum

Red flour beetle

Tcas\TC005500

Pediculus humanus

Human body louse

Phum\PHUM216210

Pediculus humanus

Human body louse

Phum\PHUM392810

Pediculus humanus

Human body louse

Phum\PHUM098090

Rhodnius prolixus

Kissing bug

Rpro\RPRC015124

Cimex lectularius

Bed bug

Clec\CLEC011913

Cimex lectularius

Bed bug

Clec\CLEC011911

Cimex lectularius

Bed bug

Clec\CLEC005976

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI004824

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI002524

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_07544

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_03928

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_09264

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X059O )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR007778

Strigamia maritima

European centipede

Smar\SMAR009219

Ixodes scapularis

Black-legged tick

Isca\ISCW001311

Ixodes scapularis

Black-legged tick

Isca\ISCW019087

Ixodes scapularis

Black-legged tick

Isca\ISCW007964

Ixodes scapularis

Black-legged tick

Isca\ISCW004264

Stegodyphus mimosarum

African social velvet spider

Smim\KFM74875.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM61888.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM71636.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur30g02140

Tetranychus urticae

Two-spotted spider mite

Turt\tetur05g03460

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_97944

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_53984

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_250728

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_39340

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G06A9 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-CbpdDL_2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-CbpdDL_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-CpdL

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_027454gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-CbpdEL

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-CbpdDL_3

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-CbpdDL

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-CbpdEL_1

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000012109

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000011276

Gallus gallus

Domestic chicken

Ggal\CPZ

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000027788

Gallus gallus

Domestic chicken

Ggal\CPXM2

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000026047

Gallus gallus

Domestic chicken

Ggal\CPN1

Gallus gallus

Domestic chicken

Ggal\CPD

Gallus gallus

Domestic chicken

Ggal\CPM

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (2)

Gene Symbol

Score

Source

Alignment

4 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

CPN1; carboxypeptidase N subunit 1

model of carboxypeptidase N deficiency

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

svr^EP356

ameliorates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Cao et al., 2008)

ameliorates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Cao et al., 2008)

exacerbates Alzheimer's disease

modeled by Hsap\APP^{Aβ42.GMR.Tag:SS(rPENK)}

(Cao et al., 2008)

svr^KG02090

exacerbates Alzheimer's disease

modeled by Hsap\APP^{Aβ42.GMR.Tag:SS(rPENK)}

(Cao et al., 2008)

svr¹²⁶

exacerbates Alzheimer's disease

modeled by Hsap\APP^{Aβ42.GMR.Tag:SS(rPENK)}

(Cao et al., 2008)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CPD; carboxypeptidase D

12 of 15

603102

CPE; carboxypeptidase E

4 of 15

114855

CPM; carboxypeptidase M

3 of 15

114860

CPN1; carboxypeptidase N subunit 1

3 of 15

603103

CARBOXYPEPTIDASE N DEFICIENCY

carboxypeptidase N deficiency

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

svr

enhanceable

svr

suppressible

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

pnr

suppressible

svr

(Pena-Rangel et al., 2002)

suppressible

suppressible

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

57568

DroID - A comprehensive database of gene and protein interactions.

FBgn0004648

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

30998

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-0

Cytogenetic map

1B5-1B7

Sequence location

X:496,446..509,072 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

1B5-1B7

Limits computationally determined from genome sequence between P{EP}CG17896^EP1320&P{EP}EP1398 and P{EP}svr^EP356&P{EP}arg^EP452

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-0

(FlyBase, 2016)

1-0.0

(Comeron et al., 2012, Goldschmidt, 1944)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (28)

124

126

127

31407

w¹¹¹⁸; P{UAS-svr.2-3-t2}3

31408

w¹¹¹⁸; P{UAS-svr.1B-2-t2}3

31405

w¹¹¹⁸; P{UAS-svr.1B-short}3

101191

105746

105747

101192

105748

v330524

More stocks available...

Genomic Clones (13)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (189)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0004648

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0004648

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

30998

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: svr CG4122

(Nusskern, 1999.11)

Source for database merge of

Source for merge of: svr CG18503

(Ashburner, 2000.5.29)

Source for merge of: svr CpepE

(FlyBase, 1996-)

Additional comments

Source for merge of svr CpepE was sequence comparison ( date:000117 ).

(FlyBase, 1996-)

may be allelic to pld: pallid

Other Comments

S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

(Stroschein-Stevenson et al., 2006)

svr has been cloned and sequenced.

(Bernasconi, 1994)

Origin and Etymology

Discoverer

Bridges, 23rd July 1923.

Etymology

Identification

External Crossreferences and Linkouts ( 99 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

30998

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P42787

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0004648

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

svr_1
svr_2

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4122

Flygut - An atlas of the Drosophila adult midgut

FBgn0004648

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

30998

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG4122

MEROPS - An information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them.

M14.011

modMine - A data warehouse for the modENCODE project

FBgn0004648

Linkouts

BioGRID - A database of protein and genetic interactions.

57568

DroID - A comprehensive database of gene and protein interactions.

FBgn0004648

DRSC - Results frm RNAi screens

FBgn0004648

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0004648

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG4122-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0004648

FlyMine - An integrated database for Drosophila genomics

FBgn0004648

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

30998

Synonyms and Secondary IDs (25)

Reported As

Symbol Synonym

CG18503

(Ashburner, 2000.5.29, Benos, 2000.12.13)

CG32818

CG4122

(Meadows, 2018.4.4, Aradska et al., 2015, Ni et al., 2010.12.1, Larschan et al., 2007, Larschan et al., 2007, Karlsson et al., 2004, Bourbon et al., 2002, Benos, 2000.12.13)

(Bernasconi, 1994)

CPD

(Tanco et al., 2010, Sidyelyeva and Fricker, 2002)

CpepE

CypD

(Cao et al., 2008)

EG:171D11.3

(Benos et al., 2001, Benos, 2000.12.13)

EP(X)0356

(Pena-Rangel et al., 2002)

dwp

l(1)1Bd

poi

slv

(Dobzhansky, 1932)

svr

(Aboukilila et al., 2020, Hung et al., 2020, Rust et al., 2020, Lu et al., 2016, Carnes et al., 2015, Borner et al., 2014, Yamamoto et al., 2013-, Japanese National Institute of Genetics, 2012.5.21, Mudiganti et al., 2010, Sidyelyeva et al., 2010, Tanco et al., 2010, Tan et al., 2009, Anaka et al., 2008, Cao et al., 2008, Sidyelyeva et al., 2006, Stroschein-Stevenson et al., 2006, Wright, 1987)

Name Synonyms

Carboxypeptidase D

(Sidyelyeva et al., 2006)

Carboxypeptidase E

DmSilver

(Pillmann et al., 2011)

Silver

(Pillmann et al., 2011)

carboxypeptidase

(Bernasconi, 1993.12.1)

carboxypeptidase D

(Sidyelyeva and Fricker, 2002)

chlorotic

dwarp

pointed

silver

(Carnes et al., 2015, Winbush et al., 2012, Sidyelyeva et al., 2010, Tanco et al., 2010, Cao et al., 2008, Wright, 1987)

Secondary FlyBase IDs

FBgn0000268
FBgn0000521
FBgn0003652
FBgn0012063
FBgn0029527
FBgn0052818

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (106)

The following external sites may use different assemblies or annotations than FlyBase.

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