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Gene Dmel\svr

General Information
Symbol	Dmel\svr	Species	D. melanogaster
Name	silver	Annotation symbol	CG4122
Feature type	protein_coding_gene	FlyBase ID	FBgn0004648
Gene Model Status	Current	Stock availability	29 publicly available
Also Known As	CPD, EG:171D11.3, CG18503
Genomic Location
Chromosome (arm)	X	Recombination map	1-0.0
Cytogenetic map	1B5-1B7	Sequence location	X:390,479..403,113 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene silver is referred to in FlyBase by the symbol Dmel\svr (CG4122, FBgn0004648). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: carboxypeptidase activity; metallocarboxypeptidase activity. There is experimental evidence that it is involved in the biological process: long-term memory; imaginal disc-derived wing morphogenesis; phagocytosis, engulfment. 73 alleles are reported. The phenotypes of these alleles are annotated with: adult segment; organ system subdivision; organ system; thoracic segment; adult; region of integument; sense organ; cell cluster organ; wing vein L1; mechanosensory sensory organ. It has 10 annotated transcripts and 10 annotated polypeptides. Protein features are: Carbohydrate-binding-like fold; Carboxypeptidase, regulatory domain; Carboxypeptidase-like, regulatory domain; Peptidase M14, carboxypeptidase A. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult salivary gland. Comments on Affy2 ProbeSet: ProbeSet 1633733_a_at completely aligns to an exonic region of only a subset of 6 of the 8 FlyBase-annotated transcript isoforms of svr. Gene sequence location is X:390479..403113.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	svr: silver Color of legs, wings, veins, and integument pale and silvery. Bristles and trident pattern on thorax dark. Tyrosinase formed in adult (Horowitz). Wings of all males and some females pointed. Viability fair. Larval mouth parts normal in color. RK2.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 1B5-1B7   Limits computationally determined from genome sequence between P{EP}CG17896EP1320&P{EP}EP1398 and P{EP}svrEP356&P{EP}argEP452
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	1-0.0 (Goldschmidt, 1944)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\svr for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.50
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) svr-RB FBtr0070081  NM_080293   5898   1406 svr-RC FBtr0070083  NM_176679   5985   1259 svr-RD FBtr0070084  NM_206599   5912   1404 svr-RE FBtr0070085  NM_206598   3157   433 svr-RF FBtr0070086  NM_206597   3143   435 svr-RG FBtr0070087  NM_206596   5836   1439 svr-RH FBtr0290016  NM_166846   5850   1437 svr-RI FBtr0290017  NM_001144669   5354   1292 svr-RJ FBtr0340146     3105   433 svr-RK FBtr0340147     5151   1411
Additional Transcript Data & Comments
Reported size (kB)	6-7, 3.9, 3.3, 2.5, 1.5 (compiled cDNA) (Settle et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein svr-PB   FBpp0070080   158.8   1406   6.74     NP_525032   AAF45514 svr-PC   FBpp0070082   142.4   1259   6.75     NP_788852   AAO41630 svr-PD   FBpp0089123   158.5   1404   6.42     NP_996322   AAS65237 svr-PE   FBpp0089124   48.3   433   4.96     NP_996321   AAS65238 svr-PF   FBpp0089125   48.6   435   6.27     NP_996320   AAS65240 svr-PG   FBpp0089126   162.7   1439   6.31     NP_996319   AAS65239 svr-PH   FBpp0288455   162.4   1437   5.97     NP_726675   AAF45515 svr-PI   FBpp0288456   146.3   1292   6.27     NP_001138141   ACL82874 svr-PJ   FBpp0309132   48.3   433   4.96       svr-PK   FBpp0309133   159.5   1411   6.16
Additional Polypeptide Data & Comments
Reported size (kDa)	1119 (aa); 126.5 (kD predicted) (Settle et al., 1995)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Carboxypeptidase, regulatory domain (IPR014766) Peptidase M14, carboxypeptidase A (IPR000834) Carboxypeptidase-like, regulatory domain (IPR008969) Carbohydrate-binding-like fold (IPR013784) MEROPS - An information resource for peptidases and the proteins that inhibit them • M14.011
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA567954   AA695126   AA941041   AA949925   AE014298 AAF45514   AE014298 AAF45515   AE014298 AAO41630   AE014298 AAS65237   AE014298 AAS65238   AE014298 AAS65239   AE014298 AAS65240   AE014298 ACL82874   AF545816 AAN73045   AF545817 AAN73046   AF545818 AAN73047   AF545819 AAN73048   AF545820 AAN73049   AI113459   AI135362   AI260641   AI295074   AI297884   AI404316   AL009147 CAA15634   AL009147 CAA15635   AQ025323   BH854521   BI164592   BI164789   BI165004   BI167620   BI167699   BI170139   BI170404   BI216719   BI235612   BI235638   BI362385   BI366399   BI367906   BI369241   BI370971   BI371417   BI484809   BI486383   BI573761   BI577855   BI578610   BI580720   BI583572   BI584664   BI585632   BI593340   BI607878   BI608339   BI617256   BP541732   BQ102885   BT015253   BT029935   BT099720   BT100053   BT100310   CK657906   CK659454   CO177020   CO178212   CO179143   CO180184   CO180370   CO183841   CO186344   CO189220   CO192025   CO194142   CO261815   CO262884   CO267615   CO270963   CO273495   CO274150   CO274403   CO277132   CO278142   CO279026   CO281300   CO282432   CO286134   CO286235   CO286994   CO287509   CO287802   CO287823   CO288137   CO290161   CO290422   CO292796   CO293414   CO293439   CO295043   CO295613   CO297341   CO299747   CO300502   CO302063   CO302744   CO303850   CO304252   CO304870   CO306396   CO307971   CO310101   CO311617   CO312346   CO313078   CO314028   CO314575   CO314893   CO325064   CO325777   CO328085   CO331706   CO333562   CO340461   CO340845   CO340886   CO341208   CO342629   CO343153   CO344572   CZ472818   CZ474038   CZ474307   CZ474763   CZ475329   CZ475330   CZ475337   CZ482265   CZ482330   CZ483666   DN153942   DN154010   EC051482   EC051818   EC052858   EC053342   EC053346   EC055460   EC056126   EC056886   EC058601   EC058885   EC060496   EC063738   EC064055   EC064728   EC067275   EC068341   EC068782   EC072052   EC072578   EC073266   EC074458   EC075106   EC075457   EC077317   EC080420   EC083991   EC087689   EC088025   EC088234   EC088373   EC088564   EC196733   EC196734   EC198143   EC198467   EC199203   EC203706   EC206464   EC207218   EC207587   EC207795   EC209603   EC212476   EC212945   EC213937   EC218501   EC218920   EC219570   EC222670   EC225294   EC225295   EC226901   EC227073   EC228084   EC228121   EC229046   EC229374   EC230127   EC230349   EC231902   EC232230   EC233679   EC235429   EC235794   EC235999   EC236395   EC241236   EC242646   EC245447   EC245801   EC248726   EC252116   EC255937   EC256136   EC256488   EC257096   EC257264   EC258582   EL884391   EL884627   EL884628   EL884736   EV585647   U03883 AAC46486   U29591 AAA91650   U29592 AAA91651   Z31732
UniProtKB/Swiss-Prot	P42787
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Settle et al., 1995)
Additional Descriptive Data
	svr transcripts are detected in Northern blots of embryonic RNA. (Settle et al., 1995)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
extracellular region inferred from direct assay (Karlsson et al., 2004) perinuclear region of cytoplasm inferred from direct assay (Sidyelyeva et al., 2010)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult salivary gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    26.725 Larval Midgut    35.1 Larval Hindgut    41.5 Larval Malpighian Tubules    37.5 Larval Fat Body    88.4 Larval Salivary Gland    122.3 Larval Trachea    30.35 Larval Carcass    27.3 Adult Head    32.5 Adult Eye    8.775 Adult Brain    26.4 Adult Thoracic-Abdominal Ganglion    18.8 Adult Crop    49.6 Adult Midgut    47.1 Adult Hindgut    41.9 Adult Malpighian Tubules    13.8 Adult Fat Body    81.6 Adult Salivary Gland    113.4 Adult Heart    26.7 Adult VirginFemale Spermatheca    21.7 Adult InseminatedFemale Spermatheca    22.7 Adult Ovary    52.9 Adult Testis    10.8 Adult Male Accessory Gland    77.7 Adult Carcass    53.1 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    26.725 Larval Midgut    35.1 Larval Hindgut    41.5 Larval Malpighian Tubules    37.5 Larval Fat Body    88.4 Larval Salivary Gland    122.3 Larval Trachea    30.35 Larval Carcass    27.3 Adult Head    32.5 Adult Eye    8.775 Adult Brain    26.4 Adult Thoracic-Abdominal Ganglion    18.8 Adult Crop    49.6 Adult Midgut    47.1 Adult Hindgut    41.9 Adult Malpighian Tubules    13.8 Adult Fat Body    81.6 Adult Salivary Gland    113.4 Adult Heart    26.7 Adult VirginFemale Spermatheca    21.7 Adult InseminatedFemale Spermatheca    22.7 Adult Ovary    52.9 Adult Testis    10.8 Adult Male Accessory Gland    77.7 Adult Carcass    53.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    26.725 Larval Midgut    35.1 Larval Hindgut    41.5 Larval Malpighian Tubules    37.5 Larval Fat Body    88.4 Larval Salivary Gland    122.3 Larval Trachea    30.35 Larval Carcass    27.3 Adult Head    32.5 Adult Eye    8.775 Adult Brain    26.4 Adult Thoracic-Abdominal Ganglion    18.8 Adult Crop    49.6 Adult Midgut    47.1 Adult Hindgut    41.9 Adult Malpighian Tubules    13.8 Adult Fat Body    81.6 Adult Salivary Gland    113.4 Adult Heart    26.7 Adult VirginFemale Spermatheca    21.7 Adult InseminatedFemale Spermatheca    22.7 Adult Ovary    52.9 Adult Testis    10.8 Adult Male Accessory Gland    77.7 Adult Carcass    53.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    26.725 Larval Midgut    35.1 Larval Hindgut    41.5 Larval Malpighian Tubules    37.5 Larval Fat Body    88.4 Larval Salivary Gland    122.3 Larval Trachea    30.35 Larval Carcass    27.3 Adult Head    32.5 Adult Eye    8.775 Adult Brain    26.4 Adult Thoracic-Abdominal Ganglion    18.8 Adult Crop    49.6 Adult Midgut    47.1 Adult Hindgut    41.9 Adult Malpighian Tubules    13.8 Adult Fat Body    81.6 Adult Salivary Gland    113.4 Adult Heart    26.7 Adult VirginFemale Spermatheca    21.7 Adult InseminatedFemale Spermatheca    22.7 Adult Ovary    52.9 Adult Testis    10.8 Adult Male Accessory Gland    77.7 Adult Carcass    53.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    26.725 Larval Midgut    35.1 Larval Hindgut    41.5 Larval Malpighian Tubules    37.5 Larval Fat Body    88.4 Larval Salivary Gland    122.3 Larval Trachea    30.35 Larval Carcass    27.3 Adult Head    32.5 Adult Eye    8.775 Adult Brain    26.4 Adult Thoracic-Abdominal Ganglion    18.8 Adult Crop    49.6 Adult Midgut    47.1 Adult Hindgut    41.9 Adult Malpighian Tubules    13.8 Adult Fat Body    81.6 Adult Salivary Gland    113.4 Adult Heart    26.7 Adult VirginFemale Spermatheca    21.7 Adult InseminatedFemale Spermatheca    22.7 Adult Ovary    52.9 Adult Testis    10.8 Adult Male Accessory Gland    77.7 Adult Carcass    53.1 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    26.725 Larval Midgut    35.1 Larval Hindgut    41.5 Larval Malpighian Tubules    37.5 Larval Fat Body    88.4 Larval Salivary Gland    122.3 Larval Trachea    30.35 Larval Carcass    27.3 Adult Head    32.5 Adult Eye    8.775 Adult Brain    26.4 Adult Thoracic-Abdominal Ganglion    18.8 Adult Crop    49.6 Adult Midgut    47.1 Adult Hindgut    41.9 Adult Malpighian Tubules    13.8 Adult Fat Body    81.6 Adult Salivary Gland    113.4 Adult Heart    26.7 Adult VirginFemale Spermatheca    21.7 Adult InseminatedFemale Spermatheca    22.7 Adult Ovary    52.9 Adult Testis    10.8 Adult Male Accessory Gland    77.7 Adult Carcass    53.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    26.725 Larval Midgut    35.1 Larval Hindgut    41.5 Larval Malpighian Tubules    37.5 Larval Fat Body    88.4 Larval Salivary Gland    122.3 Larval Trachea    30.35 Larval Carcass    27.3 Adult Head    32.5 Adult Eye    8.775 Adult Brain    26.4 Adult Thoracic-Abdominal Ganglion    18.8 Adult Crop    49.6 Adult Midgut    47.1 Adult Hindgut    41.9 Adult Malpighian Tubules    13.8 Adult Fat Body    81.6 Adult Salivary Gland    113.4 Adult Heart    26.7 Adult VirginFemale Spermatheca    21.7 Adult InseminatedFemale Spermatheca    22.7 Adult Ovary    52.9 Adult Testis    10.8 Adult Male Accessory Gland    77.7 Adult Carcass    53.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    26.725 Larval Midgut    35.1 Larval Hindgut    41.5 Larval Malpighian Tubules    37.5 Larval Fat Body    88.4 Larval Salivary Gland    122.3 Larval Trachea    30.35 Larval Carcass    27.3 Adult Head    32.5 Adult Eye    8.775 Adult Brain    26.4 Adult Thoracic-Abdominal Ganglion    18.8 Adult Crop    49.6 Adult Midgut    47.1 Adult Hindgut    41.9 Adult Malpighian Tubules    13.8 Adult Fat Body    81.6 Adult Salivary Gland    113.4 Adult Heart    26.7 Adult VirginFemale Spermatheca    21.7 Adult InseminatedFemale Spermatheca    22.7 Adult Ovary    52.9 Adult Testis    10.8 Adult Male Accessory Gland    77.7 Adult Carcass    53.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    32.5   NA  Eye    8.775   NA  Brain    26.4   26.725  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    49.6   no informative data  Midgut    no informative data   41.5  Hindgut    41.9   no informative data  Malpighian Tubules    no informative data   88.4  Fat Body    81.6   122.3  Salivary Gland    113.4   NA  Heart    26.7   30.35  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    52.9   NA  Testis    no informative data   NA  Male Accessory Gland    77.7   no informative data  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    20 central nervous system, pupae P8    33 head, virgin 1-day female    26 head, virgin 4-day female    28 head, virgin 20-day female    33 head, mated 1-day female    21 head, mated 4-day female    27 head, mated 20-day female    24 head, mated 1-day male    38 head, mated 4-day male    44 head, mated 20-day male    49 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    27 digestive system, larvae L3 wandering    22 digestive system, 1-day adult    13 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering    34 fat body, white prepupae    57 fat body, pupae P8    29 carcass, larvae L3 wandering    10 carcass, 1-day adult    14 carcass, 4-day adult    15 carcass, 20-day adult    16 ovary, virgin 4-day female    29 ovary, mated 4-day female    22 testis, mated 4-day male    4 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    20 central nervous system, pupae P8  (33) head, virgin 1-day female  26 head, virgin 4-day female  (28) head, virgin 20-day female  (33) head, mated 1-day female    21 head, mated 4-day female  (27) head, mated 20-day female    24 head, mated 1-day male  (38) head, mated 4-day male  (44) head, mated 20-day male  (49) salivary gland, larvae L3 wandering    9 salivary gland, white prepupae  (27) digestive system, larvae L3 wandering    22 digestive system, 1-day adult    13 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering  (34) fat body, white prepupae  (57) fat body, pupae P8  (29) carcass, larvae L3 wandering    10 carcass, 1-day adult    14 carcass, 4-day adult    15 carcass, 20-day adult    16 ovary, virgin 4-day female  (29) ovary, mated 4-day female    22 testis, mated 4-day male    4 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    20 central nervous system, pupae P8    33 head, virgin 1-day female    26 head, virgin 4-day female    28 head, virgin 20-day female    33 head, mated 1-day female    21 head, mated 4-day female    27 head, mated 20-day female    24 head, mated 1-day male    38 head, mated 4-day male    44 head, mated 20-day male    49 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    27 digestive system, larvae L3 wandering    22 digestive system, 1-day adult    13 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering    34 fat body, white prepupae    57 fat body, pupae P8    29 carcass, larvae L3 wandering    10 carcass, 1-day adult    14 carcass, 4-day adult    15 carcass, 20-day adult    16 ovary, virgin 4-day female    29 ovary, mated 4-day female    22 testis, mated 4-day male    4 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    20 central nervous system, pupae P8    33 head, virgin 1-day female    26 head, virgin 4-day female    28 head, virgin 20-day female    33 head, mated 1-day female    21 head, mated 4-day female    27 head, mated 20-day female    24 head, mated 1-day male    38 head, mated 4-day male    44 head, mated 20-day male    49 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    27 digestive system, larvae L3 wandering    22 digestive system, 1-day adult    13 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering    34 fat body, white prepupae    57 fat body, pupae P8    29 carcass, larvae L3 wandering    10 carcass, 1-day adult    14 carcass, 4-day adult    15 carcass, 20-day adult    16 ovary, virgin 4-day female    29 ovary, mated 4-day female    22 testis, mated 4-day male    4 accessory gland, mated 4-day male    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    20 central nervous system, pupae P8    33 head, virgin 1-day female    26 head, virgin 4-day female    28 head, virgin 20-day female    33 head, mated 1-day female    21 head, mated 4-day female    27 head, mated 20-day female    24 head, mated 1-day male    38 head, mated 4-day male    44 head, mated 20-day male    49 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    27 digestive system, larvae L3 wandering    22 digestive system, 1-day adult    13 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering    34 fat body, white prepupae    57 fat body, pupae P8    29 carcass, larvae L3 wandering    10 carcass, 1-day adult    14 carcass, 4-day adult    15 carcass, 20-day adult    16 ovary, virgin 4-day female    29 ovary, mated 4-day female    22 testis, mated 4-day male    4 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    20 central nervous system, pupae P8  (33) head, virgin 1-day female  26 head, virgin 4-day female  28 head, virgin 20-day female  (33) head, mated 1-day female    21 head, mated 4-day female  27 head, mated 20-day female    24 head, mated 1-day male  (38) head, mated 4-day male  (44) head, mated 20-day male  (49) salivary gland, larvae L3 wandering    9 salivary gland, white prepupae  27 digestive system, larvae L3 wandering    22 digestive system, 1-day adult    13 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering  (34) fat body, white prepupae  (57) fat body, pupae P8  29 carcass, larvae L3 wandering    10 carcass, 1-day adult    14 carcass, 4-day adult    15 carcass, 20-day adult    16 ovary, virgin 4-day female  29 ovary, mated 4-day female    22 testis, mated 4-day male    4 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    20 central nervous system, pupae P8    33 head, virgin 1-day female    26 head, virgin 4-day female    28 head, virgin 20-day female    33 head, mated 1-day female    21 head, mated 4-day female    27 head, mated 20-day female    24 head, mated 1-day male    38 head, mated 4-day male    44 head, mated 20-day male    49 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    27 digestive system, larvae L3 wandering    22 digestive system, 1-day adult    13 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering    34 fat body, white prepupae    57 fat body, pupae P8    29 carcass, larvae L3 wandering    10 carcass, 1-day adult    14 carcass, 4-day adult    15 carcass, 20-day adult    16 ovary, virgin 4-day female    29 ovary, mated 4-day female    22 testis, mated 4-day male    4 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    20 central nervous system, pupae P8    33 head, virgin 1-day female    26 head, virgin 4-day female    28 head, virgin 20-day female    33 head, mated 1-day female    21 head, mated 4-day female    27 head, mated 20-day female    24 head, mated 1-day male    38 head, mated 4-day male    44 head, mated 20-day male    49 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    27 digestive system, larvae L3 wandering    22 digestive system, 1-day adult    13 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering    34 fat body, white prepupae    57 fat body, pupae P8    29 carcass, larvae L3 wandering    10 carcass, 1-day adult    14 carcass, 4-day adult    15 carcass, 20-day adult    16 ovary, virgin 4-day female    29 ovary, mated 4-day female    22 testis, mated 4-day male    4 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    26 embryo 04-06hr    18 embryo 06-08hr    17 embryo 08-10hr    20 embryo 10-12hr    13 embryo 12-14hr    18 embryo 14-16hr    17 embryo 16-18hr    21 embryo 18-20hr    17 embryo 20-22hr    20 embryo 22-24hr    23 larva L1    14 larva L2    14 larva L3 12hr old    13 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    28 larva L3 puffstage 7-9    28 white prepupae new    36 white prepupae 12hr    21 white prepupae 24hr    20 pupae 2d postWPP    23 pupae 3d postWPP    21 pupae 4d postWPP    11 adult male 01day    15 adult male 05day    15 adult male 30day    13 adult female 01day    17 adult female 05day    24 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (28) embryo 02-04hr  26 embryo 04-06hr    18 embryo 06-08hr    17 embryo 08-10hr    20 embryo 10-12hr    13 embryo 12-14hr    18 embryo 14-16hr    17 embryo 16-18hr    21 embryo 18-20hr    17 embryo 20-22hr    20 embryo 22-24hr    23 larva L1    14 larva L2    14 larva L3 12hr old    13 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6  (28) larva L3 puffstage 7-9  (28) white prepupae new  (36) white prepupae 12hr    21 white prepupae 24hr    20 pupae 2d postWPP    23 pupae 3d postWPP    21 pupae 4d postWPP    11 adult male 01day    15 adult male 05day    15 adult male 30day    13 adult female 01day    17 adult female 05day    24 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    26 embryo 04-06hr    18 embryo 06-08hr    17 embryo 08-10hr    20 embryo 10-12hr    13 embryo 12-14hr    18 embryo 14-16hr    17 embryo 16-18hr    21 embryo 18-20hr    17 embryo 20-22hr    20 embryo 22-24hr    23 larva L1    14 larva L2    14 larva L3 12hr old    13 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    28 larva L3 puffstage 7-9    28 white prepupae new    36 white prepupae 12hr    21 white prepupae 24hr    20 pupae 2d postWPP    23 pupae 3d postWPP    21 pupae 4d postWPP    11 adult male 01day    15 adult male 05day    15 adult male 30day    13 adult female 01day    17 adult female 05day    24 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    26 embryo 04-06hr    18 embryo 06-08hr    17 embryo 08-10hr    20 embryo 10-12hr    13 embryo 12-14hr    18 embryo 14-16hr    17 embryo 16-18hr    21 embryo 18-20hr    17 embryo 20-22hr    20 embryo 22-24hr    23 larva L1    14 larva L2    14 larva L3 12hr old    13 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    28 larva L3 puffstage 7-9    28 white prepupae new    36 white prepupae 12hr    21 white prepupae 24hr    20 pupae 2d postWPP    23 pupae 3d postWPP    21 pupae 4d postWPP    11 adult male 01day    15 adult male 05day    15 adult male 30day    13 adult female 01day    17 adult female 05day    24 adult female 30day    24 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    26 embryo 04-06hr    18 embryo 06-08hr    17 embryo 08-10hr    20 embryo 10-12hr    13 embryo 12-14hr    18 embryo 14-16hr    17 embryo 16-18hr    21 embryo 18-20hr    17 embryo 20-22hr    20 embryo 22-24hr    23 larva L1    14 larva L2    14 larva L3 12hr old    13 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    28 larva L3 puffstage 7-9    28 white prepupae new    36 white prepupae 12hr    21 white prepupae 24hr    20 pupae 2d postWPP    23 pupae 3d postWPP    21 pupae 4d postWPP    11 adult male 01day    15 adult male 05day    15 adult male 30day    13 adult female 01day    17 adult female 05day    24 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  28 embryo 02-04hr  26 embryo 04-06hr    18 embryo 06-08hr    17 embryo 08-10hr    20 embryo 10-12hr    13 embryo 12-14hr    18 embryo 14-16hr    17 embryo 16-18hr    21 embryo 18-20hr    17 embryo 20-22hr    20 embryo 22-24hr    23 larva L1    14 larva L2    14 larva L3 12hr old    13 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6  28 larva L3 puffstage 7-9  28 white prepupae new  (36) white prepupae 12hr    21 white prepupae 24hr    20 pupae 2d postWPP    23 pupae 3d postWPP    21 pupae 4d postWPP    11 adult male 01day    15 adult male 05day    15 adult male 30day    13 adult female 01day    17 adult female 05day    24 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    26 embryo 04-06hr    18 embryo 06-08hr    17 embryo 08-10hr    20 embryo 10-12hr    13 embryo 12-14hr    18 embryo 14-16hr    17 embryo 16-18hr    21 embryo 18-20hr    17 embryo 20-22hr    20 embryo 22-24hr    23 larva L1    14 larva L2    14 larva L3 12hr old    13 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    28 larva L3 puffstage 7-9    28 white prepupae new    36 white prepupae 12hr    21 white prepupae 24hr    20 pupae 2d postWPP    23 pupae 3d postWPP    21 pupae 4d postWPP    11 adult male 01day    15 adult male 05day    15 adult male 30day    13 adult female 01day    17 adult female 05day    24 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    26 embryo 04-06hr    18 embryo 06-08hr    17 embryo 08-10hr    20 embryo 10-12hr    13 embryo 12-14hr    18 embryo 14-16hr    17 embryo 16-18hr    21 embryo 18-20hr    17 embryo 20-22hr    20 embryo 22-24hr    23 larva L1    14 larva L2    14 larva L3 12hr old    13 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    28 larva L3 puffstage 7-9    28 white prepupae new    36 white prepupae 12hr    21 white prepupae 24hr    20 pupae 2d postWPP    23 pupae 3d postWPP    21 pupae 4d postWPP    11 adult male 01day    15 adult male 05day    15 adult male 30day    13 adult female 01day    17 adult female 05day    24 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    35 embryonic 1182-4H    25 embryonic GM2    14 embryonic Kc167    17 embryonic S1    29 embryonic S3    88 leg disc CME L1    31 wing disc CME-W2    48 wing disc ML-DmD8    20 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    35 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    43 tumorous blood cells mbn2    35 ovary fGS/OSS    6 ovary OSC    13 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4  (35) embryonic 1182-4H    25 embryonic GM2    14 embryonic Kc167    17 embryonic S1  (29) embryonic S3  (88) leg disc CME L1  (31) wing disc CME-W2  (48) wing disc ML-DmD8    20 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    14 wing disc ML-DmD21  (35) wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2  (43) tumorous blood cells mbn2  (35) ovary fGS/OSS    6 ovary OSC    13 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    35 embryonic 1182-4H    25 embryonic GM2    14 embryonic Kc167    17 embryonic S1    29 embryonic S3    88 leg disc CME L1    31 wing disc CME-W2    48 wing disc ML-DmD8    20 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    35 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    43 tumorous blood cells mbn2    35 ovary fGS/OSS    6 ovary OSC    13 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    35 embryonic 1182-4H    25 embryonic GM2    14 embryonic Kc167    17 embryonic S1    29 embryonic S3    88 leg disc CME L1    31 wing disc CME-W2    48 wing disc ML-DmD8    20 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    35 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    43 tumorous blood cells mbn2    35 ovary fGS/OSS    6 ovary OSC    13 ovary OSS    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    35 embryonic 1182-4H    25 embryonic GM2    14 embryonic Kc167    17 embryonic S1    29 embryonic S3    88 leg disc CME L1    31 wing disc CME-W2    48 wing disc ML-DmD8    20 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    35 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    43 tumorous blood cells mbn2    35 ovary fGS/OSS    6 ovary OSC    13 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4  (35) embryonic 1182-4H    25 embryonic GM2    14 embryonic Kc167    17 embryonic S1  29 embryonic S3  (88) leg disc CME L1  31 wing disc CME-W2  (48) wing disc ML-DmD8    20 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    14 wing disc ML-DmD21  (35) wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2  (43) tumorous blood cells mbn2  (35) ovary fGS/OSS    6 ovary OSC    13 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    35 embryonic 1182-4H    25 embryonic GM2    14 embryonic Kc167    17 embryonic S1    29 embryonic S3    88 leg disc CME L1    31 wing disc CME-W2    48 wing disc ML-DmD8    20 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    35 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    43 tumorous blood cells mbn2    35 ovary fGS/OSS    6 ovary OSC    13 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    35 embryonic 1182-4H    25 embryonic GM2    14 embryonic Kc167    17 embryonic S1    29 embryonic S3    88 leg disc CME L1    31 wing disc CME-W2    48 wing disc ML-DmD8    20 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    35 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    43 tumorous blood cells mbn2    35 ovary fGS/OSS    6 ovary OSC    13 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    19 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    21 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    19 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    21 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    19 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    21 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    19 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    21 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    19 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    21 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    19 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    21 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    19 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    21 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    19 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    21 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_27 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004648 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4122-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | larval stage svr8 lethal | larval stage | recessive svr8 svrPG33 lethal | recessive svrPG33 svrPG47 partially lethal - majority die | recessive svrdwp viable svr1 svr73L12 svrpoi viable | poor svrcc svrcc-y viable | recessive svrPoi Sterility Allele fertile svrdwp fertile | poor svrcc-y Other Phenotypes Allele body color defective svr1 svrcc svrcc-y svrdwp svrpoi body color defective | recessive svr1 cold stress response defective | recessive svr1 svrpoi electrophoretic variant svr73L12 svrpoi memory defective | recessive svr1 svrpoi visible svr1 svrpoi visible (with svr1) svrPG33 visible (with svrPG33) svr1 svrpoi visible (with svrpoi) svrPG33 visible | recessive svrcc svrcc-y svrdwp svrpoi-dish Phenotype manifest in Allele anterior crossvein svr1 svrpoi microchaeta svrpoi-dish posterior crossvein svr1 svrpoi wing svr1 svrPoi svrPoi-s svrdwp svrpoi svrpoi-Ca svrpoi-bl svrpoi-ll svrpoi-s svrpoi-si svrpoi-sq wing blade svr1 svrpoi wing blade (with svr1) svrPG33 wing blade (with svrPG33) svr1 svrpoi wing blade (with svrpoi) svrPG33 wing vein (with svr1) svrPG33 wing vein (with svrPG33) svr1 svrpoi wing vein (with svrpoi) svrPG33 wing vein L1 svrpoi wing vein L2 svrpoi wing vein L3 svr1 svrpoi wing vein L4 svr1 svrpoi wing vein L5 svr1
Classical Alleles ( 61 )
For All Classical Alleles Show
Allele of svr Class Mutagen Stocks Known lesion svr1 hypomorphic allele - genetic evidence 4 Yes svrpoi-dish spontaneous 3 -- svrpoi spontaneous 2 Yes svrCB-0879-3 1 -- svrd02452 P-element activity 1 -- svrd04628 P-element activity 1 -- svre04517 piggyBac transposase 1 -- svre04576 piggyBac transposase 1 -- svrEP356 P-element activity 1 Yes svrf01187 piggyBac transposase 1 -- svrKG02090 P-element activity 1 -- svrNP2073 1 -- svrNP2198 1 -- svrNP3600 1 -- svrPG33 Delta2-3 1 -- svr10 ethyl methanesulfonate 0 -- svr11 ethyl methanesulfonate 0 -- svr126 0 -- svr12 ethyl methanesulfonate 0 -- svr13 ethyl methanesulfonate 0 -- svr14 ethyl methanesulfonate 0 -- svr15 ethyl methanesulfonate 0 -- svr16 ethyl methanesulfonate 0 -- svr17 ethyl nitrosourea 0 -- svr18 ethyl nitrosourea 0 -- svr19 ethyl nitrosourea 0 -- svr20 ethyl nitrosourea 0 -- svr264-104 X ray 0 -- svr2 ethyl methanesulfonate 0 -- svr3 ethyl methanesulfonate 0 -- svr4 methyl methanesulfonate 0 -- svr5-HA-2117 0 -- svr5 methyl methanesulfonate 0 -- svr6 X ray 0 -- svr73L12 spontaneous 0 Yes svr7 X ray 0 -- svr8 ethyl methanesulfonate 0 -- svr9 ethyl methanesulfonate 0 -- svrcc-y spontaneous 0 -- svrcc spontaneous 0 -- svrd05072 P-element activity 0 -- svrd05858 P-element activity 0 -- svrd06759 P-element activity 0 -- svrd06768 P-element activity 0 -- svrdwp 0 -- svrGG01306 0 -- svrGG01527 0 -- svrPG47 Delta2-3 0 -- svrpoi-bl spontaneous 0 -- svrpoi-Ca spontaneous 0 -- svrpoi-h heat-treatment 0 -- svrpoi-ll spontaneous 0 -- svrPoi-s spontaneous 0 -- svrpoi-s spontaneous 0 -- svrpoi-si spontaneous 0 -- svrpoi-sq spontaneous 0 -- svrPoi spontaneous 0 -- svrts1 ethyl methanesulfonate 0 -- svrts2 ethyl nitrosourea 0 -- svrts3 ethyl nitrosourea 0 -- svrunspecified 0 --
Alleles Carried on Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Allele of svr Class Mutagen Stocks Known lesion svr1B-2-3-t2.Scer\UAS in vitro construct - regulatory fusion 2 Yes svr1A-2-3-t2.Scer\UAS in vitro construct - regulatory fusion 1 Yes svr1B-2-1A-t2.Scer\UAS in vitro construct - regulatory fusion in vitro construct 1 Yes svr1B-2-t2.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 1 Yes svr1B-short.Scer\UAS in vitro construct - regulatory fusion 1 Yes svr2-3-t2.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 1 Yes svrsvr1A-short.Scer\UAS in vitro construct - regulatory fusion 1 Yes svr1B-2-1B-t2.Scer\UAS in vitro construct - regulatory fusion in vitro construct 0 Yes svr1B-2-3-t1.Scer\UAS in vitro construct - regulatory fusion 0 Yes svrGD3168 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes svrNIG.4122R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes svrt13.4 in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Duplicated in	Dp(1;1)100 (Dobzhansky, 1932) Dp(1;1)105 (Dobzhansky, 1932) Dp(1;1)112 (Dobzhansky, 1932) Dp(1;f)100 (Morgan, 1938) Dp(1;f)102 (Dobzhansky, 1932) Dp(1;f)106 (Dobzhansky, 1932) Dp(1;f)107 (Dobzhansky, 1932) Dp(1;f)118 (Dobzhansky, 1932) Dp(1;f)118YM (Yamamoto and Miklos, 1977) Dp(1;f)136 (Dobzhansky, 1932) Dp(1;f)137 (Dobzhansky, 1932) Dp(1;Y)59k9-4 (Kramers et al., 1983, Kramers et al., 1991) Dp(1;Y)y267g19.1 (Lefevre, 1981, Schalet, 1986) Ts(1Lt;2Lt)Bld
Not disrupted in	Df(1)260-1 (Sutton, 1943) Df(1)403 (Kramers et al., 1991) Df(1)A94 (Kramers et al., 1991) Df(1)cin-arth (Kramers et al., 1983, Kramers et al., 1991) Df(1)HA18 (Schalet, 1986) Df(1)MMG2 (Green, 1982) Df(1)MMG4 (Green, 1982) Df(1)S39 (Kramers et al., 1991) Df(1)Sp(br-dor) (Schalet, 1986) Df(1)Sp(J1a) (Schalet, 1986) Df(1)Sp(J1b) (Schalet, 1986) Df(1)Sp(J1c) (Schalet, 1986) Df(1)sta (Kramers et al., 1991) In(1)272-13 (Sutton, 1943) In(1)sc260-14 (Sutton, 1943) In(1)sc260-22 (Sutton, 1943) In(1)y4Lsc8R   T(1;2;3)sc260-18 (Sutton, 1943) T(1;2;3)sc260-29 (Sutton, 1943) T(1;2)sc260-17 (Sutton, 1943) T(1;3)sc260-20 (Sutton, 1943) T(1;?)sc260-23 (Sutton, 1943) Tp(1;2)sc260-27 (Sutton, 1943) Tp(2;1)sc260-26 (Sutton, 1943)
Not duplicated in	Dp(1;3)sta (Kramers et al., 1991) Ts(1Lt;3Rt)sc260-20
Disrupted in	Df(1)Exel6221 (Ryder, 2004.4.26) Df(1)MMG3 (Green, 1982) Df(1)svr (Kramers et al., 1983, Kramers et al., 1991, Park and Yamamoto, 1993, Sutton, 1943, California Institute of Technology, 1940) Df(1)y74k24.1 (Kramers et al., 1983, Kramers et al., 1991) Df(1)y-(1) (Settle et al., 1995) Df(1)y-(2) (Settle et al., 1995)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3168} NA P{NIG.4122R} NA P{UAS-svr.1A-2-3-t2} NA P{UAS-svr.1A-short} NA P{UAS-svr.1B-2-1A-t2} NA P{UAS-svr.1B-2-1B-t2} NA P{UAS-svr.1B-2-3-t1} NA P{UAS-svr.1B-2-3-t2} NA P{UAS-svr.1B-2-t2} NA P{UAS-svr.1B-short} NA P{UAS-svr.2-3-t2} NA characterization construct P{svrt13.4} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}svrEP356 NA P{Mae-UAS.6.11}svrGG01306 NA P{Mae-UAS.6.11}svrGG01527 NA P{XP}svrd02452 NA P{XP}svrd04628 NA P{XP}svrd05072 NA P{XP}svrd05858 NA P{XP}svrd06759 NA P{XP}svrd06768 NA miscellaneous insertions ?{}svr73L12 NA P{RS3}svrCB-0879-3 NA P{RS5}svr5-HA-2117 NA P{SUPor-P}svrKG02090 NA PBac{RB}svre04517 NA PBac{RB}svre04576 NA PBac{WH}svrf01187 NA insertion of enhancer trap binary system P{GawB}svrNP2073 No P{GawB}svrNP2198 No P{GawB}svrNP3600 No P{GawB}svrPG33 No P{GawB}svrPG47 No
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function
CV term Evidence References
carboxypeptidase activity inferred from direct assay (Sidyelyeva et al., 2006) inferred from mutant phenotype (Sidyelyeva et al., 2010) metallocarboxypeptidase activity inferred from direct assay (Sidyelyeva and Fricker, 2002)
Biological Process
CV term Evidence References
imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Sidyelyeva et al., 2006) long-term memory inferred from mutant phenotype (Sidyelyeva et al., 2010) phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006)
Cellular Component
CV term Evidence References
extracellular region inferred from direct assay (Karlsson et al., 2004) perinuclear region of cytoplasm inferred from direct assay (Sidyelyeva et al., 2010)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
carbohydrate binding inferred from electronic annotation with InterPro:IPR013784 (FlyBase Curators et al., 2004-) metallocarboxypeptidase activity non-traceable author statement (Bernasconi, 1993.12.1, Burtis, 1995.6.13) zinc ion binding inferred from electronic annotation with InterPro:IPR000834 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
chitin-based cuticle development non-traceable author statement (Swiss-Prot Project Members, 1995.6.1) proteolysis inferred from electronic annotation with InterPro:IPR000834 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions svr allele Gene References svrEP356 pnr (Pena-Rangel et al., 2002) unspecified a
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 57568 DroID - A comprehensive database of gene and protein interactions. • FBgn0004648 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 30998
Orthologs
OrthoDB Orthologs (48) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG60023J Dipteran inclusive ortholog search EOG644KT7 Insect inclusive ortholog search EOG631ZSX Arthropod inclusive ortholog search EOG68PK13 Metazoa inclusive ortholog search EOG6PW1RD
Orthologs in Drosophila Species (EOG60023J)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\svr     Drosophila simulans   Dsim\GD16509 Y   Drosophila sechellia   Dsec\GM19071 Y   Drosophila erecta   Dere\GG12791 Y   Drosophila yakuba   Dyak\GE16618 Y   Drosophila ananassae   Dana\GF21938 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA29134 Y   Drosophila persimilis   Dper\GL20387 Y   Drosophila willistoni   Dwil\GK16509 Y   Drosophila virilis   Dvir\GJ14862 Y   Drosophila mojavensis   Dmoj\GI15159 Y   Drosophila grimshawi   Dgri\GH24780 Y
Orthologs in non-Drosophila Dipterans (EOG644KT7)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL017499   Anopheles gambiae Malaria mosquito  Agam\AGAP002414   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ009464
Orthologs in non-Dipteran Insects (EOG631ZSX)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB41454   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG012195   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH23302   Atta cephalotes Leafcutter ant  Acep\ACEP25813   Camponotus floridanus Florida carpenter ant  Cflo\CFLO13716   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19565   Linepithema humile Argentine ant  Lhum\LH13835   Pogonomyrmex barbatus Red harvester ant  Pbar\PB12238   Acyrthosiphon pisum Pea aphid  Apim\ACYPI004424   Acyrthosiphon pisum Pea aphid  Apim\ACYPI002524   Bombyx mori Silkmoth  Bmor\BGIBMGA012806   Bombyx mori Silkmoth  Bmor\BGIBMGA012807   Pediculus humanus Human body louse  Phum\PHUM392810   Tribolium castaneum Red flour beetle  Tcas\GLEAN_15532
Orthologs in non-Insect Arthropods (EOG68PK13)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_250728   Ixodes scapularis Deer tick  Isca\ISCW007964
Orthologs in non-Arthropod Metazoa (EOG6PW1RD)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\T27A8.1 Y Caenorhabditis elegans Nematode  Cele\F59A3.1 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_019777gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_017575gn Y Danio rerio Zebrafish  Drer\zgc:152928 Y Danio rerio Zebrafish  Drer\si:dkey-11p6.1 Y Danio rerio Zebrafish  Drer\cpd Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000017956 Y Xenopus tropicalis Western clawed frog  Xtro\cpm Y Gallus gallus Domestic chicken  Ggal\CPD Y Gallus gallus Domestic chicken  Ggal\CPM Y Mus musculus House mouse  Mmus\Cpd Y Mus musculus House mouse  Mmus\Cpm Y Rattus norvegicus Norway rat  Rnor\Cpd Y Rattus norvegicus Norway rat  Rnor\Cpm Y Homo sapiens Human  Hsap\ENSG00000135678 Y Homo sapiens Human  Hsap\CPD Y
Human Orthologs (2)
Gene OMIM HGNC Hsap\ENSG00000135678     Hsap\CPD
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD16509 Drosophila sechellia Dsec\GM19071 Drosophila erecta Dere\GG12791 Drosophila yakuba Dyak\GE16618 Drosophila ananassae Dana\GF21938 Drosophila pseudoobscura pseudoobscura Dpse\GA29134 Drosophila persimilis Dper\GL20387 Drosophila willistoni Dwil\GK16509 Drosophila virilis Dvir\GJ14862 Drosophila mojavensis Dmoj\GI15159 Drosophila grimshawi Dgri\GH24780
Stocks & Reagents
Stocks Listed in FlyBase ( 29 )
Bloomington	124 svr1 126 svrpoi
Harvard	- P{XP}svrd02452 - P{XP}svrd04628 - PBac{RB}svre04517 - PBac{RB}svre04576 - PBac{WH}svrf01187
Kyoto	101191 svr1 105746 svr1 105747 svrpoi 101192 svrpoi-dish 105748 svrpoi-dish bbG3
	More stocks available...
Genomic Clones ( 1 )
	BACR08O05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 189 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD28490 LP12324 LP15968
Other clones	FI13044 IP15787
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH09748 GH13060 GH23969 GM02182 HL02042 LD23786 LP04580 LP08595 LP17227 RE04293 RE04535 RE04801 RE08042 RE08141 RE11505 RE11833 RE23946 RE29142 RE31504 RE31542 RE46928 RE51927 RE53777 RE55362 RE57759 RE58296 RE67965 RE69801 RE71612 RE72496 RE74943 RH11350 RH11853 RH12750 RH22221 RH23919 RH25253 RH47529
Other clones	1657 11157 12444 12681 16244 17007 21144 30129 38129 38340 39676 44964 50451 53757 61422 70089 72035 72184 73391 74619 77162 77520 77738 78878 83136 100055 101790 102351 106144 108474 117851 118454 121279 144991 153149 161888 164924 183239 214385.1 273358 273967 CK01.2B.G10 CK01.15D.A12 CK01.20B.E7 CK01.27D.E3 CK01.31B.D2 CK01.31B.F1 CK01.53D.D2 CK01.64A.E6 CK01.70B.F2 CK01.79C.E12 CK01.84A.A12 CK01.84A.C5 CK01.85D.H5 CK01.94A.G7 CK01.95A.B4 CK01.103A.B2 CK01.104B.F1 CK01.117B.E10 CK01.133A.C4 Dmel_dig_004341_0587_2266 EC01167 EC01467 EC26516 EC32629 EC37516 EC051482 EC051818 EC052858 EC053342 EC053346 EC055460 EC056126 EC256136 EC256488 EC257096 EC257264 EC258582 EK018913 EK043445 EK052151 EK056053 EK058607 EK061850 EK062203 EK064539 EK066049 EK066836 EK066911 EK067831 EK073228 EK073929 EK079821 EK086637 EK101202 EK111148 EK113362 EK114022 EK123122 EK128947 EK133306 EK139052 EK150951 EK151125 EK156412 EK160458 EK176446 EK178361 EK183001 EK184822 EK195506 EK197432 EK200959 EK202857 EK202925 EK208427 EK210940 EK216730 EK220509 EK225558 EK228524 EK231222 EK234733 EK237045 EK238162 EK242949 EK244210 EK246609 EK250942 EK256317 EK301161 EK307304 EP08540 EP10706 EP11440 EP11520 EP12039 EP15235 EP16210 EP19527 FGC004G10 IP15687 IP15887 IP15987 RH09282 UUGC0279
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004648 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 30998
Antibody Information
Other Information
Discoverer
	Bridges, 23rd July 1923.
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: svr CG4122 (Nusskern, 1999.11)
Source for database merge of	Source for merge of: svr CG18503 (Ashburner, 2000.5.29) Source for merge of: svr CpepE (FlyBase, 1996-)
Additional comments	Source for merge of svr CpepE was sequence comparison (date:000117). (FlyBase, 1996-) may be allelic to pld: pallid
Other Comments
	S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. (Stroschein-Stevenson et al., 2006) svr has been cloned and sequenced. (Bernasconi, 1994)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080293 NM_166846 NM_176679 NM_206596 NM_206597 NM_206598 NM_206599 NM_001144669 RefSeq (Proteins) • NP_525032 NP_726675 NP_788852 NP_996319 NP_996320 NP_996321 NP_996322 NP_001138141 DDBJ / EMBL / GenBank • AA949925 AAA91650 AAA91651 AAC46486 AAF45514 AAF45514.2 AAF45515 AAF45515.3 AAN73045 AAN73046 AAN73047 AAN73048 AAN73049 AAO41630 AAO41630.1 AAS65237 AAS65237.1 AAS65238 AAS65238.1 AAS65239 AAS65239.1 AAS65240 AAS65240.1 ACL82874 AF545816 AF545817 AF545818 AF545819 AF545820 AI295074 AI297884 AL009147 AQ025323 BH854521 CAA15634 CAA15635 CZ472818 CZ474038 CZ474307 CZ474763 CZ475329 CZ475330 CZ475337 CZ482265 CZ482330 CZ483666 U03883 U29591 U29592 Z31732 Entrez Gene - A searchable database of RefSeq genes. • 30998 UniProtKB/Swiss-Prot • P42787
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Carboxypeptidase, regulatory domain (IPR014766) Peptidase M14, carboxypeptidase A (IPR000834) Carboxypeptidase-like, regulatory domain (IPR008969) Carbohydrate-binding-like fold (IPR013784) MEROPS - An information resource for peptidases and the proteins that inhibit them • M14.011
Linkouts
	BioGRID - A database of protein and genetic interactions • 57568 DroID - A comprehensive database of gene and protein interactions. • FBgn0004648 DRSC - Results from RNAi screens. • FBgn0004648 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004648 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4122-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004648 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 30998 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 30998 modMine - Data generated by the modENCODE project. • FBgn0004648
Synonyms & Secondary IDs ( 25 )
Reported As
Symbol Synonym	cc   CG4122 (Karlsson et al., 2004, Bourbon et al., 2002, Benos, 2000.12.13, Larschan et al., 2007, Larschan et al., 2007) CG18503 (Benos, 2000.12.13, Ashburner, 2000.5.29, ) CG32818   CP (Bernasconi, 1994) CPD (Sidyelyeva and Fricker, 2002, Tanco et al., 2010) CpepE   CypD (Cao et al., 2008) dwp   EG:171D11.3 (Benos et al., 2001, Benos, 2000.12.13, ) EP(X)0356 (Pena-Rangel et al., 2002) l(1)1Bd   poi   slv (Dobzhansky, 1932, ) svr (Cao et al., 2008, Sidyelyeva et al., 2006, Stroschein-Stevenson et al., 2006, Mudiganti et al., 2010, Anaka et al., 2008, Wright, 1987, Sidyelyeva et al., 2010, Tanco et al., 2010, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym	carboxypeptidase (Bernasconi, 1993.12.1) carboxypeptidase D (Sidyelyeva and Fricker, 2002) Carboxypeptidase D (Sidyelyeva et al., 2006) Carboxypeptidase E   chlorotic   DmSilver (Pillmann et al., 2011) dwarp   pointed   silver (Cao et al., 2008, Wright, 1987, Sidyelyeva et al., 2010, Tanco et al., 2010) Silver (Pillmann et al., 2011)
Secondary FlyBase IDs
	FBgn0000268 FBgn0000521 FBgn0003652 FBgn0012063 FBgn0029527 FBgn0052818
References ( 75 )
Generate a list of	All references relating to this gene ( 75 )
List References by type	Research paper  ( 43 ) Supplementary material  ( 5 ) Review  ( 3 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 1 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 3 ) Stock list  ( 2 ) Curated genome annotation  ( 3 ) Protein sequence record  ( 1 ) Book  ( 3 )
Recent research papers ( 1 )
	Pillmann et al., 2011, BMC Bioinformatics 12: 270 Predicting mutually exclusive spliced exons based on exon length, splice site and reading frame conservation, and exon sequence homology. [FBrf0214445] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...