Gene Dmel\fru

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General Information

Symbol

Dmel\fru

Species

D. melanogaster

Name

fruitless

Annotation symbol

CG14307

Feature type

protein_coding_gene

FlyBase ID

FBgn0004652

Gene Model Status

Current

Stock availability

34 publicly available

Also Known As

CG7689, CG7690, CG7688, BTB-VI, sat

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

91A6-91B3

Sequence location

3R:14,239,995..14,371,308 [-]

Genomic Maps

Select View:

Summary Information

Automatically generated summary

See sections below for more information

The gene fruitless is referred to in FlyBase by the symbol Dmel\fru (CG14307, FBgn0004652). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: sequence-specific DNA binding transcription factor activity. There is experimental evidence for 13 unique biological process terms, many of which group under: multi-organism reproductive process; mating; single-organism developmental process; system development; cellular component organization or biogenesis; multicellular organismal development; courtship behavior; male courtship behavior, veined wing extension; neuron differentiation; developmental process involved in reproduction. 103 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; adult segment; embryonic/larval neuron; adult antennal lobe; thoracic segment; male accessory gland; non-connected developing system; external compound sense organ; male abdominal 5 muscle. It has 15 annotated transcripts and 15 annotated polypeptides. Protein features are: BTB/POZ; BTB/POZ fold; BTB/POZ-like; Zinc finger C2H2-type/integrase DNA-binding domain; Zinc finger, C2H2; Zinc finger, C2H2-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, during late pupal stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression in all larval and adult organs/tissues ranges from low to undetected. Expression at high levels in the following post-embryonic organs or tissues: adult eye. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system, larval trachea. Gene sequence location is 3R:14239995..14371308.

User Contributed Data

Beta version, feedback welcome

External Summaries

Phenotypic Description from the Red Book (Lindsley & Zimm 1992)

Gene/Allele symbols may differ from current usage

fru: fruitless (J.C. Hall)

Males court but do not mate with females; fru males court other males (especially when such flies also are homozygous for fru) and stimulate vigorous courtship on the part of fru or wild-type males. Mutant males produce volatile compounds different from those generated by normal males, on criteria of gas chromatography and bioassays of behavioral effects of these compounds; females appear to be unaffected by fru, which is not allelic to sr.

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

Alleles

fru[MI05389]

fru[MI07841]

FB2013_02

All updates

Click here to see a list of all updates to this record from FB2010_08 and on.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

91A6-91B3

Limits computationally determined from genome sequence between P{PZ}sprd⁰⁵²⁸⁴ and P{PZ}cdi⁰⁷⁰¹³&P{lacW}nos^j3B6

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

91A-91B

(Laski, 1994.9.5)

91B1-91B8

(determined by in situ hybridisation)

(Spradling et al., 1999)

91B-91B

(determined by in situ hybridisation)

(Ito et al., 1995)

91B1-91B8

(BDGP Project Members, 1994-1999)

91B1-91B2

The sterility and chain formation phenotypes of In(3R)fru males co-map to the distal In(3R)fru breakpoint.

(Gailey and Hall, 1989)

Experimentally Determined Recombination Data

Location

(Laski, 1994.9.5)

Left of (cM)

Right of (cM)

(Moses et al., 1989)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\fru for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Gene model reviewed during 5.44

Stop-codon suppression (UGA) postulated; FBrf0216884.

gene_with_stop_codon_read_through ; SO:0000697

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.46

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

fru-RA

FBtr0083646

NM_169821

5546

516

fru-RB

FBtr0083641

NM_169816

4159

789

fru-RC

FBtr0083642

NM_169820

5140

854

fru-RD

FBtr0083647

NM_169822

2254

665

fru-RE

FBtr0083643

NM_169819

3539

955

fru-RF

FBtr0083644

NM_079673

6960

688

fru-RG

FBtr0083645

NM_169817

6798

796

fru-RH

FBtr0083640

NM_169818

8399

695

fru-RI

FBtr0083648

NM_206516

2842

870

fru-RJ

FBtr0083649

NM_206515

2994

906

fru-RK

FBtr0083650

NM_206514

6650

705

fru-RL

FBtr0083651

NM_206513

3402

854

fru-RM

FBtr0083652

NM_206512

2845

854

fru-RN

FBtr0301284

NM_001170177

3554

960

fru-RO

FBtr0330040

NM_001275783

8399

882

Additional Transcript Data & Comments

Reported size (kB)

9.0, 8.0, 7.9, 7.4, 6.4, 5.4, 4.4 (northern blot)

(Ryner et al., 1996)

5.0, 4.3 (northern blot); 2.852 (longest cDNA)

(Ito et al., 1996)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

fru-PA

FBpp0083066

55.1

516

5.75

NP_732349

AAF55564

fru-PB

FBpp0083061

84.0

789

7.67

NP_732344

AAF55562

fru-PC

FBpp0083062

91.9

854

6.83

NP_732348

AAF55565

fru-PD

FBpp0083067

72.4

665

7.93

NP_732350

AAN13777

fru-PE

FBpp0083063

102.9

955

7.02

NP_732347

AAN13776

fru-PF

FBpp0083064

73.1

688

7.45

NP_524397

AAN13774

fru-PG

FBpp0083065

86.5

796

7.55

NP_732345

AAF55563

fru-PH

FBpp0083060

75.5

695

7.32

NP_732346

AAN13775

fru-PI

FBpp0089355

93.8

870

6.92

NP_996238

AAS65173

fru-PJ

FBpp0089356

97.6

906

6.88

NP_996237

AAS65174

fru-PK

FBpp0089357

76.7

705

7.32

NP_996236

AAS65172

fru-PL

FBpp0089358

91.9

854

6.83

NP_996235

AAS65175

fru-PM

FBpp0089359

91.9

854

6.83

NP_996234

AAS65176

fru-PN

FBpp0290499

103.4

960

7.02

NP_001163648

ACZ94944

fru-PO

FBpp0303073

97.7

882

7.28

NP_001262712

AGB96092

Additional Polypeptide Data & Comments

Reported size (kDa)

855 (aa)

(Ito et al., 1996)

776, 675 (aa)

(Ryner et al., 1996)

Comments

Multiple fru proteins are produced from alternatively spliced fru transcripts. A female-specific form of fru protein lacks 101 N-terminal amino acids present in a male-specific fru protein. Differences are also found in the zinc finger pairs present at the carboxy terminus. In related proteins, these zinc finger pairs confer distinct DNA-binding specificity and are expressed in cell-specific patterns.

(Ryner et al., 1996)

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

BTB/POZ-like (IPR000210)

Zinc finger, C2H2 (IPR007087)

BTB/POZ (IPR013069)

BTB/POZ fold (IPR011333)

Zinc finger, C2H2-like (IPR015880)

Zinc finger C2H2-type/integrase DNA-binding domain (IPR013087)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Q8IN81

UniProtKB/TrEMBL

E1JIP5

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism | ubiquitous

(Fisher et al., 2012)

Comment:maternally deposited

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | faint & ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | faint & ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | faint & ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

third instar larval stage

mushroom body

(Ito et al., 1996)

optic lobe

(Ito et al., 1996)

ventral nerve cord

(Ito et al., 1996)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | male

central nervous system | restricted

head

adult head

adult stage | female

adult head

(Ryner et al., 1996)

central nervous system | restricted

(Ryner et al., 1996)

(Ito et al., 1996)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

pupal stage | male

brain | restricted

(Goto et al., 2011)

pupal stage P6 | male

ventral nerve cord | restricted

(Goto et al., 2011)

pharate adult stage & male -- adult stage & male

central nervous system | restricted

(Billeter and Goodwin, 2004)

central nervous system | anterior & restricted

(Billeter and Goodwin, 2004)

central nervous system | posterior & restricted

(Billeter and Goodwin, 2004)

thoracico-abdominal ganglion | restricted

(Billeter and Goodwin, 2004)

pars intercerebralis | restricted

(Billeter and Goodwin, 2004)

adult protocerebrum | faint & restricted

(Billeter and Goodwin, 2004)

adult stage | male

ventral nerve cord | restricted

(Billeter and Goodwin, 2004)

adult stage

neuron | subset

(Al-Anzi et al., 2009)

adult brain | restricted

(Al-Anzi et al., 2009)

thoracico-abdominal ganglion | restricted

(Al-Anzi et al., 2009)

subesophageal ganglion | restricted

(Al-Anzi et al., 2009)

adult mushroom body | restricted

(Al-Anzi et al., 2009)

Additional Descriptive Data

fru protein is detected in around 1000 neurons in the male pupal brain, including a cluster of neurons located dorsal and medially to the antennal lobe (mAL neurons). Expression is also observed in a subset of neurons in the ventral nerve cord. Almost all neurons that express fru protein also express hb protein. A subset of the neurons marked by fru are also labelled by Scer\GAL4^fru-NP0021.

(Goto et al., 2011)

fru is expressed in two neurons of the subesophageal ganglion, and four to eight neurons in the neurosecretory cluster that contains the insulin-like producing neurons.

(Al-Anzi et al., 2009)

Expression of fru in the central nervous system peaks in intensity at the second day of pupation and becomes two-fold weaker in adults. It is seen in approximately 20 neuronal clusters distributed throughout the CNS, corresponding to approximately 2000 cells. Expression of fru is seen in the cortex of the pars intercerebralis.

(Billeter and Goodwin, 2004)

The 776aa form of fru protein is male specific.

(Ryner et al., 1996)

The 675aa form of fru protein is female specific.

(Ryner et al., 1996)

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	gene max expression
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression in all larval and adult organs/tissues ranges from low to undetected. Expression at high levels in the following post-embryonic organs or tissues: adult eye. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system, larval trachea.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (>999.999)

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		6
central nervous system, larvae L3		3
central nervous system, pupae P8		8
head, virgin 1-day female		7
head, virgin 4-day female		7
head, virgin 20-day female		4
head, mated 1-day female		7
head, mated 4-day female		5
head, mated 20-day female		4
head, mated 1-day male		7
head, mated 4-day male		7
head, mated 20-day male		6
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		1
digestive system, 1-day adult		0
digestive system, 4-day adult		1
digestive system, 20-day adult		0
fat body, larvae L3 wandering		2
fat body, white prepupae		0
fat body, pupae P8		3
carcass, larvae L3 wandering		2
carcass, 1-day adult		2
carcass, 4-day adult		2
carcass, 20-day adult		1
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		3
accessory gland, mated 4-day male		1
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		6
central nervous system, larvae L3		3
central nervous system, pupae P8		8
head, virgin 1-day female		7
head, virgin 4-day female		7
head, virgin 20-day female		4
head, mated 1-day female		7
head, mated 4-day female		5
head, mated 20-day female		4
head, mated 1-day male		7
head, mated 4-day male		7
head, mated 20-day male		6
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		1
digestive system, 1-day adult		0
digestive system, 4-day adult		1
digestive system, 20-day adult		0
fat body, larvae L3 wandering		2
fat body, white prepupae		0
fat body, pupae P8		3
carcass, larvae L3 wandering		2
carcass, 1-day adult		2
carcass, 4-day adult		2
carcass, 20-day adult		1
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		3
accessory gland, mated 4-day male		1
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		6
central nervous system, larvae L3		3
central nervous system, pupae P8		8
head, virgin 1-day female		7
head, virgin 4-day female		7
head, virgin 20-day female		4
head, mated 1-day female		7
head, mated 4-day female		5
head, mated 20-day female		4
head, mated 1-day male		7
head, mated 4-day male		7
head, mated 20-day male		6
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		1
digestive system, 1-day adult		0
digestive system, 4-day adult		1
digestive system, 20-day adult		0
fat body, larvae L3 wandering		2
fat body, white prepupae		0
fat body, pupae P8		3
carcass, larvae L3 wandering		2
carcass, 1-day adult		2
carcass, 4-day adult		2
carcass, 20-day adult		1
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		3
accessory gland, mated 4-day male		1
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		6
central nervous system, larvae L3		3
central nervous system, pupae P8		8
head, virgin 1-day female		7
head, virgin 4-day female		7
head, virgin 20-day female		4
head, mated 1-day female		7
head, mated 4-day female		5
head, mated 20-day female		4
head, mated 1-day male		7
head, mated 4-day male		7
head, mated 20-day male		6
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		1
digestive system, 1-day adult		0
digestive system, 4-day adult		1
digestive system, 20-day adult		0
fat body, larvae L3 wandering		2
fat body, white prepupae		0
fat body, pupae P8		3
carcass, larvae L3 wandering		2
carcass, 1-day adult		2
carcass, 4-day adult		2
carcass, 20-day adult		1
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		3
accessory gland, mated 4-day male		1
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		6
central nervous system, larvae L3		3
central nervous system, pupae P8		8
head, virgin 1-day female		7
head, virgin 4-day female		7
head, virgin 20-day female		4
head, mated 1-day female		7
head, mated 4-day female		5
head, mated 20-day female		4
head, mated 1-day male		7
head, mated 4-day male		7
head, mated 20-day male		6
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		1
digestive system, 1-day adult		0
digestive system, 4-day adult		1
digestive system, 20-day adult		0
fat body, larvae L3 wandering		2
fat body, white prepupae		0
fat body, pupae P8		3
carcass, larvae L3 wandering		2
carcass, 1-day adult		2
carcass, 4-day adult		2
carcass, 20-day adult		1
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		3
accessory gland, mated 4-day male		1
Expression Level Scale		Very low Low Moderate

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		6
central nervous system, larvae L3		3
central nervous system, pupae P8		8
head, virgin 1-day female		7
head, virgin 4-day female		7
head, virgin 20-day female		4
head, mated 1-day female		7
head, mated 4-day female		5
head, mated 20-day female		4
head, mated 1-day male		7
head, mated 4-day male		7
head, mated 20-day male		6
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		1
digestive system, 1-day adult		0
digestive system, 4-day adult		1
digestive system, 20-day adult		0
fat body, larvae L3 wandering		2
fat body, white prepupae		0
fat body, pupae P8		3
carcass, larvae L3 wandering		2
carcass, 1-day adult		2
carcass, 4-day adult		2
carcass, 20-day adult		1
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		3
accessory gland, mated 4-day male		1
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		6
central nervous system, larvae L3		3
central nervous system, pupae P8		8
head, virgin 1-day female		7
head, virgin 4-day female		7
head, virgin 20-day female		4
head, mated 1-day female		7
head, mated 4-day female		5
head, mated 20-day female		4
head, mated 1-day male		7
head, mated 4-day male		7
head, mated 20-day male		6
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		1
digestive system, 1-day adult		0
digestive system, 4-day adult		1
digestive system, 20-day adult		0
fat body, larvae L3 wandering		2
fat body, white prepupae		0
fat body, pupae P8		3
carcass, larvae L3 wandering		2
carcass, 1-day adult		2
carcass, 4-day adult		2
carcass, 20-day adult		1
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		3
accessory gland, mated 4-day male		1
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		6
central nervous system, larvae L3		3
central nervous system, pupae P8		8
head, virgin 1-day female		7
head, virgin 4-day female		7
head, virgin 20-day female		4
head, mated 1-day female		7
head, mated 4-day female		5
head, mated 20-day female		4
head, mated 1-day male		7
head, mated 4-day male		7
head, mated 20-day male		6
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		1
digestive system, 1-day adult		0
digestive system, 4-day adult		1
digestive system, 20-day adult		0
fat body, larvae L3 wandering		2
fat body, white prepupae		0
fat body, pupae P8		3
carcass, larvae L3 wandering		2
carcass, 1-day adult		2
carcass, 4-day adult		2
carcass, 20-day adult		1
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		3
accessory gland, mated 4-day male		1
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, during late pupal stages, in adult male stages.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		0
embryo 12-14hr		0
embryo 14-16hr		0
embryo 16-18hr		0
embryo 18-20hr		1
embryo 20-22hr		4
embryo 22-24hr		3
larva L1		3
larva L2		4
larva L3 12hr old		9
larva L3 puffstage 1-2		3
larva L3 puffstage 3-6		3
larva L3 puffstage 7-9		1
white prepupae new		1
white prepupae 12hr		1
white prepupae 24hr		2
pupae 2d postWPP		8
pupae 3d postWPP		13
pupae 4d postWPP		3
adult male 01day		3
adult male 05day		3
adult male 30day		3
adult female 01day		2
adult female 05day		1
adult female 30day		1
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		0
embryo 12-14hr		0
embryo 14-16hr		0
embryo 16-18hr		0
embryo 18-20hr		1
embryo 20-22hr		4
embryo 22-24hr		3
larva L1		3
larva L2		4
larva L3 12hr old		9
larva L3 puffstage 1-2		3
larva L3 puffstage 3-6		3
larva L3 puffstage 7-9		1
white prepupae new		1
white prepupae 12hr		1
white prepupae 24hr		2
pupae 2d postWPP		8
pupae 3d postWPP		13
pupae 4d postWPP		3
adult male 01day		3
adult male 05day		3
adult male 30day		3
adult female 01day		2
adult female 05day		1
adult female 30day		1
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		0
embryo 12-14hr		0
embryo 14-16hr		0
embryo 16-18hr		0
embryo 18-20hr		1
embryo 20-22hr		4
embryo 22-24hr		3
larva L1		3
larva L2		4
larva L3 12hr old		9
larva L3 puffstage 1-2		3
larva L3 puffstage 3-6		3
larva L3 puffstage 7-9		1
white prepupae new		1
white prepupae 12hr		1
white prepupae 24hr		2
pupae 2d postWPP		8
pupae 3d postWPP		13
pupae 4d postWPP		3
adult male 01day		3
adult male 05day		3
adult male 30day		3
adult female 01day		2
adult female 05day		1
adult female 30day		1
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		0
embryo 12-14hr		0
embryo 14-16hr		0
embryo 16-18hr		0
embryo 18-20hr		1
embryo 20-22hr		4
embryo 22-24hr		3
larva L1		3
larva L2		4
larva L3 12hr old		9
larva L3 puffstage 1-2		3
larva L3 puffstage 3-6		3
larva L3 puffstage 7-9		1
white prepupae new		1
white prepupae 12hr		1
white prepupae 24hr		2
pupae 2d postWPP		8
pupae 3d postWPP		13
pupae 4d postWPP		3
adult male 01day		3
adult male 05day		3
adult male 30day		3
adult female 01day		2
adult female 05day		1
adult female 30day		1
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		0
embryo 12-14hr		0
embryo 14-16hr		0
embryo 16-18hr		0
embryo 18-20hr		1
embryo 20-22hr		4
embryo 22-24hr		3
larva L1		3
larva L2		4
larva L3 12hr old		9
larva L3 puffstage 1-2		3
larva L3 puffstage 3-6		3
larva L3 puffstage 7-9		1
white prepupae new		1
white prepupae 12hr		1
white prepupae 24hr		2
pupae 2d postWPP		8
pupae 3d postWPP		13
pupae 4d postWPP		3
adult male 01day		3
adult male 05day		3
adult male 30day		3
adult female 01day		2
adult female 05day		1
adult female 30day		1
Expression Level Scale		Very low Low Moderate

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		0
embryo 12-14hr		0
embryo 14-16hr		0
embryo 16-18hr		0
embryo 18-20hr		1
embryo 20-22hr		4
embryo 22-24hr		3
larva L1		3
larva L2		4
larva L3 12hr old		9
larva L3 puffstage 1-2		3
larva L3 puffstage 3-6		3
larva L3 puffstage 7-9		1
white prepupae new		1
white prepupae 12hr		1
white prepupae 24hr		2
pupae 2d postWPP		8
pupae 3d postWPP		13
pupae 4d postWPP		3
adult male 01day		3
adult male 05day		3
adult male 30day		3
adult female 01day		2
adult female 05day		1
adult female 30day		1
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		0
embryo 12-14hr		0
embryo 14-16hr		0
embryo 16-18hr		0
embryo 18-20hr		1
embryo 20-22hr		4
embryo 22-24hr		3
larva L1		3
larva L2		4
larva L3 12hr old		9
larva L3 puffstage 1-2		3
larva L3 puffstage 3-6		3
larva L3 puffstage 7-9		1
white prepupae new		1
white prepupae 12hr		1
white prepupae 24hr		2
pupae 2d postWPP		8
pupae 3d postWPP		13
pupae 4d postWPP		3
adult male 01day		3
adult male 05day		3
adult male 30day		3
adult female 01day		2
adult female 05day		1
adult female 30day		1
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		0
embryo 12-14hr		0
embryo 14-16hr		0
embryo 16-18hr		0
embryo 18-20hr		1
embryo 20-22hr		4
embryo 22-24hr		3
larva L1		3
larva L2		4
larva L3 12hr old		9
larva L3 puffstage 1-2		3
larva L3 puffstage 3-6		3
larva L3 puffstage 7-9		1
white prepupae new		1
white prepupae 12hr		1
white prepupae 24hr		2
pupae 2d postWPP		8
pupae 3d postWPP		13
pupae 4d postWPP		3
adult male 01day		3
adult male 05day		3
adult male 30day		3
adult female 01day		2
adult female 05day		1
adult female 30day		1
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		17
Schneider line 2 Sg4		12
embryonic 1182-4H		11
embryonic GM2		6
embryonic Kc167		10
embryonic S1		12
embryonic S3		16
leg disc CME L1		8
wing disc CME-W2		10
wing disc ML-DmD8		11
wing disc ML-DmD9		17
wing disc ML-DmD16-c3		7
wing disc ML-DmD21		10
wing disc ML-DmD32		18
haltere disc ML-DmD17-c3		27
eye-antennal disc ML-DmD11		13
antennal disc ML-DmD20-c5		7
mixed discs ML-DmD4-c1		3
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		2
tumorous blood cells mbn2		12
ovary fGS/OSS		13
ovary OSC		9
ovary OSS		5
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		17
Schneider line 2 Sg4		12
embryonic 1182-4H		11
embryonic GM2		6
embryonic Kc167		10
embryonic S1		12
embryonic S3		16
leg disc CME L1		8
wing disc CME-W2		10
wing disc ML-DmD8		11
wing disc ML-DmD9		17
wing disc ML-DmD16-c3		7
wing disc ML-DmD21		10
wing disc ML-DmD32		18
haltere disc ML-DmD17-c3		(27)
eye-antennal disc ML-DmD11		13
antennal disc ML-DmD20-c5		7
mixed discs ML-DmD4-c1		3
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		2
tumorous blood cells mbn2		12
ovary fGS/OSS		13
ovary OSC		9
ovary OSS		5
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		17
Schneider line 2 Sg4		12
embryonic 1182-4H		11
embryonic GM2		6
embryonic Kc167		10
embryonic S1		12
embryonic S3		16
leg disc CME L1		8
wing disc CME-W2		10
wing disc ML-DmD8		11
wing disc ML-DmD9		17
wing disc ML-DmD16-c3		7
wing disc ML-DmD21		10
wing disc ML-DmD32		18
haltere disc ML-DmD17-c3		27
eye-antennal disc ML-DmD11		13
antennal disc ML-DmD20-c5		7
mixed discs ML-DmD4-c1		3
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		2
tumorous blood cells mbn2		12
ovary fGS/OSS		13
ovary OSC		9
ovary OSS		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		17
Schneider line 2 Sg4		12
embryonic 1182-4H		11
embryonic GM2		6
embryonic Kc167		10
embryonic S1		12
embryonic S3		16
leg disc CME L1		8
wing disc CME-W2		10
wing disc ML-DmD8		11
wing disc ML-DmD9		17
wing disc ML-DmD16-c3		7
wing disc ML-DmD21		10
wing disc ML-DmD32		18
haltere disc ML-DmD17-c3		27
eye-antennal disc ML-DmD11		13
antennal disc ML-DmD20-c5		7
mixed discs ML-DmD4-c1		3
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		2
tumorous blood cells mbn2		12
ovary fGS/OSS		13
ovary OSC		9
ovary OSS		5
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		17
Schneider line 2 Sg4		12
embryonic 1182-4H		11
embryonic GM2		6
embryonic Kc167		10
embryonic S1		12
embryonic S3		16
leg disc CME L1		8
wing disc CME-W2		10
wing disc ML-DmD8		11
wing disc ML-DmD9		17
wing disc ML-DmD16-c3		7
wing disc ML-DmD21		10
wing disc ML-DmD32		18
haltere disc ML-DmD17-c3		27
eye-antennal disc ML-DmD11		13
antennal disc ML-DmD20-c5		7
mixed discs ML-DmD4-c1		3
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		2
tumorous blood cells mbn2		12
ovary fGS/OSS		13
ovary OSC		9
ovary OSS		5
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		17
Schneider line 2 Sg4		12
embryonic 1182-4H		11
embryonic GM2		6
embryonic Kc167		10
embryonic S1		12
embryonic S3		16
leg disc CME L1		8
wing disc CME-W2		10
wing disc ML-DmD8		11
wing disc ML-DmD9		17
wing disc ML-DmD16-c3		7
wing disc ML-DmD21		10
wing disc ML-DmD32		18
haltere disc ML-DmD17-c3		27
eye-antennal disc ML-DmD11		13
antennal disc ML-DmD20-c5		7
mixed discs ML-DmD4-c1		3
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		2
tumorous blood cells mbn2		12
ovary fGS/OSS		13
ovary OSC		9
ovary OSS		5
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		17
Schneider line 2 Sg4		12
embryonic 1182-4H		11
embryonic GM2		6
embryonic Kc167		10
embryonic S1		12
embryonic S3		16
leg disc CME L1		8
wing disc CME-W2		10
wing disc ML-DmD8		11
wing disc ML-DmD9		17
wing disc ML-DmD16-c3		7
wing disc ML-DmD21		10
wing disc ML-DmD32		18
haltere disc ML-DmD17-c3		27
eye-antennal disc ML-DmD11		13
antennal disc ML-DmD20-c5		7
mixed discs ML-DmD4-c1		3
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		2
tumorous blood cells mbn2		12
ovary fGS/OSS		13
ovary OSC		9
ovary OSS		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		17
Schneider line 2 Sg4		12
embryonic 1182-4H		11
embryonic GM2		6
embryonic Kc167		10
embryonic S1		12
embryonic S3		16
leg disc CME L1		8
wing disc CME-W2		10
wing disc ML-DmD8		11
wing disc ML-DmD9		17
wing disc ML-DmD16-c3		7
wing disc ML-DmD21		10
wing disc ML-DmD32		18
haltere disc ML-DmD17-c3		27
eye-antennal disc ML-DmD11		13
antennal disc ML-DmD20-c5		7
mixed discs ML-DmD4-c1		3
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		2
tumorous blood cells mbn2		12
ovary fGS/OSS		13
ovary OSC		9
ovary OSS		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Cell Line		Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		2
cold shock, 4-day adult		2
heat shock, 4-day adult		4
Cadmium 50 mM 6 hrs, larvae L3		3
Cadmium 50 mM 12 hrs, larvae L3		2
Cadmium 50 mM 48 hrs, 4-day adult		4
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		6
Copper 15 mM 48 hrs, 4-day adult		2
Zinc 5 mM 12 hrs, larvae L3		4
Zinc 4.5 mM 48 hrs, 4-day adult		3
Ethanol 2.5% 3 hrs, larvae L3		2
Ethanol 5% 3 hrs, larvae L3		4
Ethanol 10% 3 hrs, larvae L3		3
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		2
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		2
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		2
cold shock, 4-day adult		2
heat shock, 4-day adult		4
Cadmium 50 mM 6 hrs, larvae L3		3
Cadmium 50 mM 12 hrs, larvae L3		2
Cadmium 50 mM 48 hrs, 4-day adult		4
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		6
Copper 15 mM 48 hrs, 4-day adult		2
Zinc 5 mM 12 hrs, larvae L3		4
Zinc 4.5 mM 48 hrs, 4-day adult		3
Ethanol 2.5% 3 hrs, larvae L3		2
Ethanol 5% 3 hrs, larvae L3		4
Ethanol 10% 3 hrs, larvae L3		3
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		2
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		2
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		2
cold shock, 4-day adult		2
heat shock, 4-day adult		4
Cadmium 50 mM 6 hrs, larvae L3		3
Cadmium 50 mM 12 hrs, larvae L3		2
Cadmium 50 mM 48 hrs, 4-day adult		4
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		6
Copper 15 mM 48 hrs, 4-day adult		2
Zinc 5 mM 12 hrs, larvae L3		4
Zinc 4.5 mM 48 hrs, 4-day adult		3
Ethanol 2.5% 3 hrs, larvae L3		2
Ethanol 5% 3 hrs, larvae L3		4
Ethanol 10% 3 hrs, larvae L3		3
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		2
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		2
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		2
cold shock, 4-day adult		2
heat shock, 4-day adult		4
Cadmium 50 mM 6 hrs, larvae L3		3
Cadmium 50 mM 12 hrs, larvae L3		2
Cadmium 50 mM 48 hrs, 4-day adult		4
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		6
Copper 15 mM 48 hrs, 4-day adult		2
Zinc 5 mM 12 hrs, larvae L3		4
Zinc 4.5 mM 48 hrs, 4-day adult		3
Ethanol 2.5% 3 hrs, larvae L3		2
Ethanol 5% 3 hrs, larvae L3		4
Ethanol 10% 3 hrs, larvae L3		3
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		2
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		2
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		2
cold shock, 4-day adult		2
heat shock, 4-day adult		4
Cadmium 50 mM 6 hrs, larvae L3		3
Cadmium 50 mM 12 hrs, larvae L3		2
Cadmium 50 mM 48 hrs, 4-day adult		4
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		6
Copper 15 mM 48 hrs, 4-day adult		2
Zinc 5 mM 12 hrs, larvae L3		4
Zinc 4.5 mM 48 hrs, 4-day adult		3
Ethanol 2.5% 3 hrs, larvae L3		2
Ethanol 5% 3 hrs, larvae L3		4
Ethanol 10% 3 hrs, larvae L3		3
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		2
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		2
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		2
cold shock, 4-day adult		2
heat shock, 4-day adult		4
Cadmium 50 mM 6 hrs, larvae L3		3
Cadmium 50 mM 12 hrs, larvae L3		2
Cadmium 50 mM 48 hrs, 4-day adult		4
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		6
Copper 15 mM 48 hrs, 4-day adult		2
Zinc 5 mM 12 hrs, larvae L3		4
Zinc 4.5 mM 48 hrs, 4-day adult		3
Ethanol 2.5% 3 hrs, larvae L3		2
Ethanol 5% 3 hrs, larvae L3		4
Ethanol 10% 3 hrs, larvae L3		3
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		2
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		2
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		2
cold shock, 4-day adult		2
heat shock, 4-day adult		4
Cadmium 50 mM 6 hrs, larvae L3		3
Cadmium 50 mM 12 hrs, larvae L3		2
Cadmium 50 mM 48 hrs, 4-day adult		4
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		6
Copper 15 mM 48 hrs, 4-day adult		2
Zinc 5 mM 12 hrs, larvae L3		4
Zinc 4.5 mM 48 hrs, 4-day adult		3
Ethanol 2.5% 3 hrs, larvae L3		2
Ethanol 5% 3 hrs, larvae L3		4
Ethanol 10% 3 hrs, larvae L3		3
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		2
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		2
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		2
cold shock, 4-day adult		2
heat shock, 4-day adult		4
Cadmium 50 mM 6 hrs, larvae L3		3
Cadmium 50 mM 12 hrs, larvae L3		2
Cadmium 50 mM 48 hrs, 4-day adult		4
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		6
Copper 15 mM 48 hrs, 4-day adult		2
Zinc 5 mM 12 hrs, larvae L3		4
Zinc 4.5 mM 48 hrs, 4-day adult		3
Ethanol 2.5% 3 hrs, larvae L3		2
Ethanol 5% 3 hrs, larvae L3		4
Ethanol 10% 3 hrs, larvae L3		3
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		2
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		2
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010)

mE2_34_mRNA_expression_cluster_10

External Data & Images

Linkouts

BDGP expression data

•

GH19932

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0004652

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG14307-RH;CG14307-RD;CG14307-RC;CG14307-RB;CG14307-RA;HDC14322;CG14307-RA

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

lethal, with Scer\GAL4^D42, fru^{BM.Scer\UAS.cUa}

fru^sat

lethal, with Scer\GAL4^D42, fru^sat

fru^{BM.Scer\UAS.cUa}

lethal (with Df(3R)Cha7)

lethal (with Df(3R)fru^w24)

lethal (with fru^4-40)

fru^M5

lethal (with fru^M5)

fru^4-40

lethal (with fru^sat15)

lethal (with fru^w9)

lethal (with fru^w12)

fru^w9

lethal (with fru^w27)

lethal | heat sensitive, with fru^AM.hs

fru^sat

lethal | heat sensitive, with fru^sat

fru^AM.hs

lethal | partially (with Df(3R)fru^w24)

fru^0-1

lethal | partially | pupal stage (with fru^w12)

fru^w27

lethal | partially | pupal stage (with fru^w27)

fru^w12

lethal | prepupal stage (with Df(3R)fru^w24)

fru^AJ96u3

lethal | prepupal stage (with fru^AJ96u3)

lethal | prepupal stage (with fru^P14)

fru^AJ96u3

lethal | prepupal stage (with fru^sat15)

fru^AJ96u3

lethal | prepupal stage | recessive

fru^AJ96u3

lethal | pupal stage (with Df(3R)fru^w24)

lethal | pupal stage (with fru^AJ96u3)

lethal | pupal stage (with fru^sat15)

fru^w12

lethal | pupal stage (with fru^w12)

lethal | pupal stage (with fru^w27)

lethal | pupal stage | recessive

fru^AJ96u3

lethal | recessive

partially lethal - majority die, with Scer\GAL4^D42, fru^{B.Scer\UAS.cUa}

fru^sat

partially lethal - majority die, with Scer\GAL4^D42, fru^{E.Scer\UAS.cUa}

fru^sat

partially lethal - majority die, with Scer\GAL4^D42, fru^sat

partially lethal - majority live

fru^ΔC

partially lethal - majority live (with Df(3R)fru^w24)

fru^ΔC

partially lethal - majority live (with fru^sat15)

fru^ΔC

partially lethal - majority live (with fru^ΔC)

fru^sat15

viable

viable (with fru^4-40)

viable (with fru⁴)

fru^AJ96u3

viable (with fru^AJ96u3)

viable (with fru^M5)

viable (with fru^P14)

viable (with fru^sat15)

Sterility

Allele

female fertile (with fru^4-40)

female fertile (with fru^C)

fru^4-40

female fertile (with fru^F)

fru^4-40

female semi-fertile (with fru^4-40)

female semi-fertile (with fru^M)

fru^4-40

female semi-fertile (with fru^Δtra)

fru^4-40

fertile

male fertile

fru^0-1

male fertile (with fru^0-1)

male fertile (with fru¹)

fru^0-1

male fertile (with fru^M5)

fru^0-1

male semi-sterile | recessive

male sterile

male sterile, with Scer\GAL4^Gp150-52A

fru^{dsRNA.M.Scer\UAS}

male sterile (with Df(3R)fru^w24)

male sterile (with fru^0-1)

male sterile (with fru¹)

male sterile (with fru³)

male sterile (with fru^4-40)

male sterile (with fru⁴)

male sterile (with fru^AJ96u3)

male sterile (with fru^M5)

male sterile (with fru^sat15)

male sterile (with fru^w9)

male sterile (with fru^w12)

male sterile (with fru^w27)

male sterile | partially (with fru^0-1)

male sterile | partially (with fru¹)

fru^sat15

male sterile | partially (with fru³)

fru^0-1

male sterile | partially (with fru^4-40)

fru^0-1

male sterile | partially (with fru⁴)

fru^0-1

male sterile | partially (with fru^sat15)

male sterile | recessive

semi-fertile

semi-fertile (with Df(3R)fru^w24)

fru^ΔC

semi-fertile (with fru³)

fru^ΔC

semi-fertile (with fru^4-40)

fru^ΔC

semi-fertile (with fru^sat15)

fru^ΔC

semi-fertile (with fru^ΔC)

semi-fertile | male

fru^GAL4.P1.D

semi-fertile | male (with fru³)

fru^GAL4.P1.D

semi-fertile | male (with fru⁴)

fru^GAL4.P1.D

semi-fertile | male (with fru^AJ96u3)

fru^GAL4.P1.D

semi-fertile | male (with fru^GAL4.P1.D)

sterile | recessive

fru^sat

Other Phenotypes

Allele

behavior defective

behavior defective | male

courtship behavior defective

courtship behavior defective, with Scer\GAL4^17d

fru^{dsRNA.M.Scer\UAS}

courtship behavior defective, with Scer\GAL4^c309

fru^{dsRNA.M.Scer\UAS}

courtship behavior defective, with Scer\GAL4^ey-OK107

fru^{dsRNA.M.Scer\UAS}

courtship behavior defective, with Scer\GAL4^Gp150-52A

fru^{dsRNA.M.Scer\UAS}

courtship behavior defective, with Scer\GAL4^H24

fru^{dsRNA.M.Scer\UAS}

courtship behavior defective, with Scer\GAL4^{Orco.2.642.T:Hsim\VP22}

fru^{dsRNA.M.Scer\UAS}

courtship behavior defective, with Scer\GAL4^Tab2-201Y

fru^{dsRNA.M.Scer\UAS}

courtship behavior defective (with fru³)

fru^ΔC

courtship behavior defective (with fru^4-40)

fru^ΔC

courtship behavior defective (with fru^NP0021)

fru^sat

courtship behavior defective (with fru^sat15)

fru^ΔC

courtship behavior defective (with fru^sat)

fru^NP0021

courtship behavior defective (with fru^ΔC)

courtship behavior defective | chemical conditional

courtship behavior defective | female

fru^M

courtship behavior defective | female (with fru^4-40)

fru^M

courtship behavior defective | female (with fru^M)

fru^4-40

courtship behavior defective | male

courtship behavior defective | male, with Scer\GAL4^SG18.1

fru^{dsRNA.M.Scer\UAS}

courtship behavior defective | male (with Df(3R)fru^w24)

courtship behavior defective | male (with fru^0-1)

courtship behavior defective | male (with fru¹)

courtship behavior defective | male (with fru³)

courtship behavior defective | male (with fru^4-40)

courtship behavior defective | male (with fru⁴)

courtship behavior defective | male (with fru^AJ96u3)

fru^GAL4.P1.D

courtship behavior defective | male (with fru^F)

fru^4-40

courtship behavior defective | male (with fru^GAL4.P1.D)

courtship behavior defective | male (with fru^M5)

courtship behavior defective | male (with fru^P14)

fru^4-40

courtship behavior defective | male (with fru^sat15)

courtship behavior defective | male (with fru^w9)

courtship behavior defective | male (with fru^w12)

courtship behavior defective | male (with fru^w27)

courtship behavior defective | male | recessive

courtship behavior defective | male limited

fru^GAL4.P1.D

courtship behavior defective | recessive

fru^sat

hypoactive | dominant | male

fru^w9

hypoactive | male (with Df(3R)fru^w24)

hypoactive | male (with fru¹)

hypoactive | male (with fru^4-40)

hypoactive | male (with fru^M5)

hypoactive | male (with fru^sat15)

hypoactive | male (with fru^w9)

hypoactive | male (with fru^w12)

hypoactive | male (with fru^w27)

mating defective

fru^0-1

mating defective, with Scer\GAL4^Tdc2.PC

fru^{dsRNA.M.Scer\UAS}

mating defective (with fru^0-1)

fru¹

mating defective (with fru¹)

mating defective (with fru³)

fru¹

mating defective (with fru⁴)

fru¹

mating defective (with fru^sat15)

fru¹

mating defective (with fru^sat)

fru¹

mating defective | recessive

neuroanatomy defective

fru^ΔC

neuroanatomy defective, with Scer\GAL4^fru.16

neuroanatomy defective, with Scer\GAL4^sca-537.4

fru^{B.Scer\UAS.cSa}

neuroanatomy defective, with Scer\GAL4^sca-537.4, fru^{MB.Scer\UAS.cSa}/fru^sat15

fru^w12

neuroanatomy defective, with Scer\GAL4^sca-537.4, fru^sat15/fru^{MA.Scer\UAS.cSa}

fru^w12

neuroanatomy defective, with Scer\GAL4^sca-537.4, fru^sat15/fru^{MC.Scer\UAS.cSa}

fru^w12

neuroanatomy defective, with Scer\GAL4^sca-537.4, fru^w12/fru^{MA.Scer\UAS.cSa}

fru^sat15

neuroanatomy defective, with Scer\GAL4^sca-537.4, fru^w12/fru^{MB.Scer\UAS.cSa}

fru^sat15

neuroanatomy defective, with Scer\GAL4^sca-537.4, fru^w12/fru^{MC.Scer\UAS.cSa}

fru^sat15

neuroanatomy defective, with Scer\GAL4^sca-537.4, fru^w12/fru^sat15

neuroanatomy defective (with Df(3R)fru^w24)

neuroanatomy defective (with fru³)

fru^ΔC

neuroanatomy defective (with fru^AJ96u3)

neuroanatomy defective (with fru^{MA.Scer\UAS.cSa}), with Scer\GAL4^sca-537.4, fru^sat15

fru^w12

neuroanatomy defective (with fru^{MA.Scer\UAS.cSa}), with Scer\GAL4^sca-537.4, fru^w12

fru^sat15

neuroanatomy defective (with fru^{MB.Scer\UAS.cSa}), with Scer\GAL4^sca-537.4, fru^sat15

fru^w12

neuroanatomy defective (with fru^{MB.Scer\UAS.cSa}), with Scer\GAL4^sca-537.4, fru^w12

fru^sat15

neuroanatomy defective (with fru^{MC.Scer\UAS.cSa}), with Scer\GAL4^sca-537.4, fru^sat15

fru^w12

neuroanatomy defective (with fru^{MC.Scer\UAS.cSa}), with Scer\GAL4^sca-537.4, fru^w12

fru^sat15

neuroanatomy defective (with fru^P14)

neuroanatomy defective (with fru^sat15)

neuroanatomy defective (with fru^sat15), with Scer\GAL4^sca-537.4, fru^{MA.Scer\UAS.cSa}

fru^w12

neuroanatomy defective (with fru^sat15), with Scer\GAL4^sca-537.4, fru^{MB.Scer\UAS.cSa}

fru^w12

neuroanatomy defective (with fru^sat15), with Scer\GAL4^sca-537.4, fru^{MC.Scer\UAS.cSa}

fru^w12

neuroanatomy defective (with fru^sat15), with Scer\GAL4^sca-537.4, fru^w12

neuroanatomy defective (with fru^w12)

neuroanatomy defective (with fru^w12), with Scer\GAL4^sca-537.4, fru^{MA.Scer\UAS.cSa}

fru^sat15

neuroanatomy defective (with fru^w12), with Scer\GAL4^sca-537.4, fru^{MB.Scer\UAS.cSa}

fru^sat15

neuroanatomy defective (with fru^w12), with Scer\GAL4^sca-537.4, fru^{MC.Scer\UAS.cSa}

fru^sat15

neuroanatomy defective (with fru^w12), with Scer\GAL4^sca-537.4, fru^sat15

neuroanatomy defective (with fru^w27)

fru^w12

neuroanatomy defective (with fru^ΔC)

fru³

neuroanatomy defective | adult stage | female, with Scer\GAL4^Poxn.14, fru^P1.LexA/fru^sat15

fru^{MC.Scer\UAS.T:BPV-1\AU1}

neuroanatomy defective | adult stage | female (with fru^P1.LexA), with Scer\GAL4^Poxn.14, fru^{MC.Scer\UAS.T:BPV-1\AU1}

fru^sat15

neuroanatomy defective | adult stage | female (with fru^sat15), with Scer\GAL4^Poxn.14, fru^{MC.Scer\UAS.T:BPV-1\AU1}

fru^P1.LexA

neuroanatomy defective | adult stage | male

fru^P1.LexA

neuroanatomy defective | adult stage | male, with Scer\GAL4^Poxn.14

neuroanatomy defective | adult stage | male (with fru^4-40)

fru^P1.LexA

neuroanatomy defective | adult stage | male (with fru^P1.LexA)

neuroanatomy defective | adult stage | male (with fru^sat15)

fru^P1.LexA

neuroanatomy defective | adult stage | male (with fru^ΔC)

fru^P1.LexA

song defective (with Df(3R)fru^w24)

song defective (with fru¹)

song defective (with fru³)

song defective (with fru^4-40)

song defective (with fru⁴)

song defective (with fru^M5)

fru^w12

song defective (with fru^w9)

song defective (with fru^w12)

song defective (with fru^w27)

song defective | recessive

fru^sat

Phenotype manifest in

Allele

aCC neuron (with fru^P14)

fru^w12

aCC neuron (with fru^w12)

fru^P14

adult abdomen & motor neuron (with Df(3R)fru^w24)

fru^w27

adult abdomen & motor neuron (with fru^w12)

fru^w27

adult abdomen & motor neuron (with fru^w27)

fru^w12

adult brain & neuron | medial | male

fru^NP0021

adult brain | female

fru^M

antennal lobe glomerulus DA1

fru^Δtra

antennal lobe glomerulus VA1

fru^Δtra

antennal lobe glomerulus VL2

fru^Δtra

anterior scutellar bristle (with fru^AJ96u3)

fru^w27

anterior scutellar bristle (with fru^w27)

fru^AJ96u3

dMP2 neuron (with fru^sat15)

fru^w12

dMP2 neuron (with fru^w12)

fru^sat15

embryonic/larval glial cell (with fru^sat15)

fru^w12

embryonic/larval glial cell (with fru^w12)

fru^sat15

eye, with Scer\GAL4^GMR.PF

fru^NP0021

joint (with Df(3R)fru^w24)

joint (with fru^AJ96u3)

fru^w27

joint (with fru^P14)

fru^w12

joint (with fru^sat15)

fru^w12

joint (with fru^w12)

joint (with fru^w27)

longitudinal connective, with Scer\GAL4^sca-537.4

fru^{B.Scer\UAS.cSa}

longitudinal connective, with Scer\GAL4^sca-537.4, fru^{MB.Scer\UAS.cSa}/fru^sat15

fru^w12

longitudinal connective, with Scer\GAL4^sca-537.4, fru^sat15/fru^{MA.Scer\UAS.cSa}

fru^w12

longitudinal connective, with Scer\GAL4^sca-537.4, fru^sat15/fru^{MC.Scer\UAS.cSa}

fru^w12

longitudinal connective, with Scer\GAL4^sca-537.4, fru^w12/fru^{MA.Scer\UAS.cSa}

fru^sat15

longitudinal connective, with Scer\GAL4^sca-537.4, fru^w12/fru^{MB.Scer\UAS.cSa}

fru^sat15

longitudinal connective, with Scer\GAL4^sca-537.4, fru^w12/fru^{MC.Scer\UAS.cSa}

fru^sat15

longitudinal connective, with Scer\GAL4^sca-537.4, fru^w12/fru^sat15

longitudinal connective (with Df(3R)fru^w24)

longitudinal connective (with fru^AJ96u3)

longitudinal connective (with fru^{MA.Scer\UAS.cSa}), with Scer\GAL4^sca-537.4, fru^sat15

fru^w12

longitudinal connective (with fru^{MA.Scer\UAS.cSa}), with Scer\GAL4^sca-537.4, fru^w12

fru^sat15

longitudinal connective (with fru^{MB.Scer\UAS.cSa}), with Scer\GAL4^sca-537.4, fru^sat15

fru^w12

longitudinal connective (with fru^{MB.Scer\UAS.cSa}), with Scer\GAL4^sca-537.4, fru^w12

fru^sat15

longitudinal connective (with fru^{MC.Scer\UAS.cSa}), with Scer\GAL4^sca-537.4, fru^sat15

fru^w12

longitudinal connective (with fru^{MC.Scer\UAS.cSa}), with Scer\GAL4^sca-537.4, fru^w12

fru^sat15

longitudinal connective (with fru^P14)

longitudinal connective (with fru^sat15)

longitudinal connective (with fru^sat15), with Scer\GAL4^sca-537.4, fru^{MA.Scer\UAS.cSa}

fru^w12

longitudinal connective (with fru^sat15), with Scer\GAL4^sca-537.4, fru^{MB.Scer\UAS.cSa}

fru^w12

longitudinal connective (with fru^sat15), with Scer\GAL4^sca-537.4, fru^{MC.Scer\UAS.cSa}

fru^w12

longitudinal connective (with fru^sat15), with Scer\GAL4^sca-537.4, fru^w12

longitudinal connective (with fru^w12)

longitudinal connective (with fru^w12), with Scer\GAL4^sca-537.4, fru^{MA.Scer\UAS.cSa}

fru^sat15

longitudinal connective (with fru^w12), with Scer\GAL4^sca-537.4, fru^{MB.Scer\UAS.cSa}

fru^sat15

longitudinal connective (with fru^w12), with Scer\GAL4^sca-537.4, fru^{MC.Scer\UAS.cSa}

fru^sat15

longitudinal connective (with fru^w12), with Scer\GAL4^sca-537.4, fru^sat15

macrochaeta | ectopic (with Df(3R)fru^w24)

macrochaeta | ectopic (with fru^P14)

fru^w12

macrochaeta | ectopic (with fru^sat15)

fru^w12

macrochaeta | ectopic (with fru^w12)

macrochaeta | ectopic (with fru^w27)

fru^w12

male abdominal 5 muscle

male abdominal 5 muscle (with Df(3R)fru^w24)

male abdominal 5 muscle (with fru^0-1)

male abdominal 5 muscle (with fru¹)

male abdominal 5 muscle (with fru³)

male abdominal 5 muscle (with fru^4-40)

male abdominal 5 muscle (with fru⁴)

male abdominal 5 muscle (with fru^F)

fru^4-40

male abdominal 5 muscle (with fru^M5)

male abdominal 5 muscle (with fru^NP0021)

fru^sat

male abdominal 5 muscle (with fru^sat)

fru^NP0021

male abdominal 5 muscle (with fru^w9)

male abdominal 5 muscle (with fru^w12)

male abdominal 5 muscle (with fru^w27)

male abdominal 5 muscle (with fru^ΔC)

fru³

male abdominal 5 muscle | ectopic | female, with Scer\GAL4^D42

fru^{B.Scer\UAS.cUa}

male abdominal 5 muscle | ectopic | female, with Scer\GAL4^D42, fru^{B.Scer\UAS.cUa}

fru^sat

male abdominal 5 muscle | ectopic | female, with Scer\GAL4^D42, fru^sat

fru^{B.Scer\UAS.cUa}

male abdominal 5 muscle | ectopic | female (with fru^4-40)

male abdominal 5 muscle | ectopic | female (with fru^M)

fru^4-40

male abdominal 5 muscle | ectopic | female (with fru^Δtra)

fru^4-40

male accessory gland

fru^ΔC

male accessory gland (with fru³)

fru^ΔC

male accessory gland (with fru^ΔC)

fru³

presumptive embryonic/larval central nervous system, with Scer\GAL4^sca-537.4

fru^{B.Scer\UAS.cSa}

presumptive embryonic/larval central nervous system, with Scer\GAL4^sca-537.4, fru^{MB.Scer\UAS.cSa}/fru^sat15

fru^w12

presumptive embryonic/larval central nervous system, with Scer\GAL4^sca-537.4, fru^sat15/fru^{MA.Scer\UAS.cSa}

fru^w12

presumptive embryonic/larval central nervous system, with Scer\GAL4^sca-537.4, fru^sat15/fru^{MC.Scer\UAS.cSa}

fru^w12

presumptive embryonic/larval central nervous system, with Scer\GAL4^sca-537.4, fru^w12/fru^{MA.Scer\UAS.cSa}

fru^sat15

presumptive embryonic/larval central nervous system, with Scer\GAL4^sca-537.4, fru^w12/fru^{MB.Scer\UAS.cSa}

fru^sat15

presumptive embryonic/larval central nervous system, with Scer\GAL4^sca-537.4, fru^w12/fru^{MC.Scer\UAS.cSa}

fru^sat15

presumptive embryonic/larval central nervous system, with Scer\GAL4^sca-537.4, fru^w12/fru^sat15

presumptive embryonic/larval central nervous system (with Df(3R)fru^w24)

presumptive embryonic/larval central nervous system (with fru^AJ96u3)

presumptive embryonic/larval central nervous system (with fru^{MA.Scer\UAS.cSa}), with Scer\GAL4^sca-537.4, fru^sat15

fru^w12

presumptive embryonic/larval central nervous system (with fru^{MA.Scer\UAS.cSa}), with Scer\GAL4^sca-537.4, fru^w12

fru^sat15

presumptive embryonic/larval central nervous system (with fru^{MB.Scer\UAS.cSa}), with Scer\GAL4^sca-537.4, fru^sat15

fru^w12

presumptive embryonic/larval central nervous system (with fru^{MB.Scer\UAS.cSa}), with Scer\GAL4^sca-537.4, fru^w12

fru^sat15

presumptive embryonic/larval central nervous system (with fru^{MC.Scer\UAS.cSa}), with Scer\GAL4^sca-537.4, fru^sat15

fru^w12

presumptive embryonic/larval central nervous system (with fru^{MC.Scer\UAS.cSa}), with Scer\GAL4^sca-537.4, fru^w12

fru^sat15

presumptive embryonic/larval central nervous system (with fru^P14)

fru^AJ96u3

presumptive embryonic/larval central nervous system (with fru^sat15)

presumptive embryonic/larval central nervous system (with fru^sat15), with Scer\GAL4^sca-537.4, fru^{MA.Scer\UAS.cSa}

fru^w12

presumptive embryonic/larval central nervous system (with fru^sat15), with Scer\GAL4^sca-537.4, fru^{MB.Scer\UAS.cSa}

fru^w12

presumptive embryonic/larval central nervous system (with fru^sat15), with Scer\GAL4^sca-537.4, fru^{MC.Scer\UAS.cSa}

fru^w12

presumptive embryonic/larval central nervous system (with fru^sat15), with Scer\GAL4^sca-537.4, fru^w12

presumptive embryonic/larval central nervous system (with fru^w12)

fru^sat15

presumptive embryonic/larval central nervous system (with fru^w12), with Scer\GAL4^sca-537.4, fru^{MA.Scer\UAS.cSa}

fru^sat15

presumptive embryonic/larval central nervous system (with fru^w12), with Scer\GAL4^sca-537.4, fru^{MB.Scer\UAS.cSa}

fru^sat15

presumptive embryonic/larval central nervous system (with fru^w12), with Scer\GAL4^sca-537.4, fru^{MC.Scer\UAS.cSa}

fru^sat15

presumptive embryonic/larval central nervous system (with fru^w12), with Scer\GAL4^sca-537.4, fru^sat15

prothoracic leg taste bristle chemosensory neuron | female, with Scer\GAL4^Poxn.14, fru^P1.LexA/fru^sat15

fru^{MC.Scer\UAS.T:BPV-1\AU1}

prothoracic leg taste bristle chemosensory neuron | female (with fru^P1.LexA), with Scer\GAL4^Poxn.14, fru^{MC.Scer\UAS.T:BPV-1\AU1}

fru^sat15

prothoracic leg taste bristle chemosensory neuron | female (with fru^sat15), with Scer\GAL4^Poxn.14, fru^{MC.Scer\UAS.T:BPV-1\AU1}

fru^P1.LexA

prothoracic leg taste bristle chemosensory neuron | male

fru^P1.LexA

prothoracic leg taste bristle chemosensory neuron | male, with Scer\GAL4^Poxn.14

prothoracic leg taste bristle chemosensory neuron | male (with fru^4-40)

fru^P1.LexA

prothoracic leg taste bristle chemosensory neuron | male (with fru^P1.LexA)

prothoracic leg taste bristle chemosensory neuron | male (with fru^sat15)

fru^P1.LexA

prothoracic leg taste bristle chemosensory neuron | male (with fru^ΔC)

fru^P1.LexA

serotonergic neuron

serotonergic neuron, with Scer\GAL4^fru.16

sternopleural bristle (with fru^AJ96u3)

fru^w27

sternopleural bristle (with fru^w27)

fru^AJ96u3

tibia (with fru^w12)

fru^w27

tibia (with fru^w27)

fru^w12

vas deferens (with fru³)

fru^ΔC

vas deferens (with fru^ΔC)

fru³

vMP2 neuron (with fru^sat15)

fru^w12

vMP2 neuron (with fru^w12)

fru^sat15

wing (with Df(3R)fru^w24)

fru^w27

wing (with fru^AJ96u3)

fru^w27

wing (with fru^P14)

fru^w12

wing (with fru^sat15)

fru^w12

wing (with fru^w12)

wing (with fru^w27)

Classical Alleles ( 63 )

For All Classical Alleles Show

Allele of fru	Class	Mutagen	Stocks	Known lesion
fru^NP0021	loss of function allele	P-element activity	2	Yes
fru³		P-element activity	1	Yes
fru^5-HA-1629			1	--
fru^c00050		piggyBac transposase	1	--
fru^c00086		piggyBac transposase	1	--
fru^c00354		piggyBac transposase	1	--
fru^C009			1	--
fru^c02866		piggyBac transposase	1	--
fru^c06337		piggyBac transposase	1	--
fru^d03344		P-element activity	1	--
fru^e00829		piggyBac transposase	1	--
fru^e02702		piggyBac transposase	1	--
fru^e04090		piggyBac transposase	1	--
fru^EY02366			1	--
fru^EY09280		P-element activity	1	--
fru^f01804		piggyBac transposase	1	--
fru^f02684			1	--
fru^f02987		piggyBac transposase	1	--
fru^f03529		piggyBac transposase	1	--
fru^f04244			1	--
fru^f04786		piggyBac transposase	1	--
fru^f07715		piggyBac transposase	1	--
fru^KG00116		P-element activity	1	--
fru^KG03989			1	--
fru^MB01996			1	--
fru^MB02472			1	--
fru^MI01523			1	--
fru^MI01850			1	--
fru^MI05389			1	--
fru^MI05459			1	--
fru^MI06350			1	--
fru^0-1		P-element activity	0	Yes
fru¹		X ray	0	Yes
fru^4-40		P-element activity	0	Yes
fru⁴		P-element activity	0	Yes
fru^AJ96u3	loss of function allele	P-element activity	0	Yes
fru^C-5'half		FLPase SCEI endonuclease recombination ends-in gene targeting	0	Yes
fru^C		FLPase	0	Yes
fru^CB-5903-3			0	--
fru^F-5'half		FLPase SCEI endonuclease recombination ends-in gene targeting	0	Yes
fru^F33.55		spontaneous	0	Yes
fru^F		FLPase	0	Yes
fru^FLP		recombination gene targeting by homologous recombination	0	Yes
fru^GAL4.GFP		FLPase SCEI endonuclease recombination ends-in gene targeting	0	Yes
fru^GAL4.P1.B		FLPase SCEI endonuclease ends-out gene targeting	0	Yes
fru^GAL4.P1.D		cre recombinase	0	Yes
fru^M-5'half		FLPase SCEI endonuclease recombination ends-in gene targeting	0	Yes
fru^M5			0	Yes
fru^M		FLPase	0	Yes
fru^MI07841			0	--
fru^P1.LexA		recombination SCEI endonuclease FLPase ends-out gene targeting	0	Yes
fru^P14			0	Yes
fru^sat15		Delta2-3	0	Yes
fru^sat		P-element activity Delta2-3	0	Yes
fru^satr2			0	Yes
fru^w12		X ray	0	Yes
fru^w13		X ray	0	--
fru^w27		X ray	0	Yes
fru^w9		X ray	0	Yes
fru^X-3'half		FLPase SCEI endonuclease recombination ends-in gene targeting	0	Yes
fru^ΔC		ethyl methanesulfonate	0	Yes
fru^Δtra-5'half		FLPase SCEI endonuclease recombination ends-in gene targeting	0	Yes
fru^Δtra		FLPase	0	Yes

Alleles Carried on Transgenic Constructs ( 42 )

For All Alleles Carried on Transgenic Constructs Show

Allele of fru	Mutagen	Stocks	Known lesion
fru^JF01182	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
fru^KK112763	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
fru^A.hs	in vitro construct - regulatory fusion	0	Yes
fru^{A.Scer\UAS.cSa}	in vitro construct - regulatory fusion	0	Yes
fru^{A.Scer\UAS.cUa}	in vitro construct - regulatory fusion	0	Yes
fru^AM.hs	in vitro construct - regulatory fusion	0	Yes
fru^{AM.Scer\UAS.cUa}	in vitro construct - regulatory fusion	0	Yes
fru^B.hs	in vitro construct - regulatory fusion	0	Yes
fru^{B.Scer\UAS.cSa}	in vitro construct - regulatory fusion	0	Yes
fru^{B.Scer\UAS.cUa}	in vitro construct - regulatory fusion	0	Yes
fru^{BM.Scer\UAS.cUa}	in vitro construct - regulatory fusion	0	Yes
fru^C-5'donor	in vitro construct - genomic fragment in vitro construct - site directed mutagenesis in vitro construct	0	Yes
fru^C.hs	in vitro construct - regulatory fusion	0	Yes
fru^{C.Scer\UAS.cSa}	in vitro construct - regulatory fusion	0	Yes
fru^{C.Scer\UAS.cUa}	in vitro construct - regulatory fusion	0	Yes
fru^D.hs	in vitro construct - regulatory fusion	0	Yes
fru^{D.Scer\UAS.cUa}	in vitro construct - regulatory fusion	0	Yes
fru^{dsRNA.C.Scer\UAS}	in vitro construct - regulatory fusion in vitro construct - RNAi	0	Yes
fru^dsRNA.cDa	in vitro construct - RNAi	0	Yes
fru^dsRNA.cDb	in vitro construct - RNAi	0	Yes
fru^{dsRNA.M.Scer\UAS}	in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes
fru^E.hs	in vitro construct - regulatory fusion	0	Yes
fru^{E.Scer\UAS.cUa}	in vitro construct - regulatory fusion	0	Yes
fru^{EM.Scer\UAS.cUa}	in vitro construct - regulatory fusion	0	Yes
fru^F-5'donor	in vitro construct - genomic fragment in vitro construct - site directed mutagenesis in vitro construct	0	Yes
fru^Fwt.Act5C	in vitro construct - deletion	0	Yes
fru^GD4349	in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes
fru^{M+FREmut.Act5C}	in vitro construct - site directed mutagenesis	0	Yes
fru^M+Fwt.Act5C	in vitro construct - regulatory fusion	0	Yes
fru^{M+FΔB-M.Act5C}	in vitro construct - deletion	0	Yes
fru^M+REds.Act5C	in vitro construct	0	Yes
fru^{M+REmut.Act5C}	in vitro construct	0	Yes
fru^M+REwt.Act5C	in vitro construct	0	Yes
fru^M-5'donor	in vitro construct - genomic fragment in vitro construct - site directed mutagenesis in vitro construct	0	Yes
fru^{MA.Scer\UAS.cSa}	in vitro construct - regulatory fusion	0	Yes
fru^{MB.Scer\UAS.cSa}	in vitro construct - regulatory fusion	0	Yes
fru^{MC.Scer\UAS.cSa}	in vitro construct - regulatory fusion	0	Yes
fru^{MC.Scer\UAS.T:BPV-1\AU1}	in vitro construct - regulatory fusion in vitro construct - coding region fusion	0	Yes
fru^{P1.LexA.Scer\SceI.RS}	in vitro construct	0	Yes
fru^{t.GAL4.GFP.donor}	in vitro construct - genomic fragment in vitro construct - site directed mutagenesis in vitro construct	0	Yes
fru^X-3'donor	in vitro construct - genomic fragment in vitro construct - site directed mutagenesis in vitro construct	0	Yes
fru^{Δtra-5'donor}	in vitro construct - genomic fragment in vitro construct - site directed mutagenesis in vitro construct	0	Yes

Aneuploid Aberrations

Disrupted in

Df(3R)BSC509

(Christensen et al., 2008.4.15)

Df(3R)Cha1a

(Gailey and Hall, 1989)

Df(3R)Cha7

(Gailey and Hall, 1989)

Df(3R)Cha^M5

(Goodwin et al., 2000, Gailey and Hall, 1989, Castrillon et al., 1993, Villella et al., 1997)

Df(3R)DG1

(Gailey and Hall, 1989)

Df(3R)DG2

(Gailey and Hall, 1989)

Df(3R)DG5

(Gailey and Hall, 1989)

Df(3R)Exel6179

(Ryder, 2004.4.26)

Df(3R)fru^4-40

(Lee and Hall, 2001, Anand et al., 2001)

Df(3R)fru^sat15

(Anand et al., 2001)

Df(3R)fru^w10

(Anand et al., 2001)

Df(3R)fru^w24

(Goodwin et al., 2000, Ryner et al., 1996)

Df(3R)fru^w25

(Anand et al., 2001)

Df(3R)gl-BX1

(Gailey and Hall, 1989)

Df(3R)gl-BX10

(Gailey and Hall, 1989)

Df(3R)P14

(Goodwin et al., 2000, Gailey and Hall, 1989, Villella et al., 1997)

In(3R)fru

(Gailey and Hall, 1989, Villella et al., 1997)

Not disrupted in

Df(3R)BX6

(Gailey and Hall, 1989)

Df(3R)Cha5

(Gailey and Hall, 1989, Villella et al., 1997)

Df(3R)DG3

(Gailey and Hall, 1989)

Df(3R)DG4

(Gailey and Hall, 1989)

Partially disrupted in

Df(3R)BX5

(Gailey and Hall, 1989)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

GAL4 construct

heat-shock construct

characterization construct

P{FRT(fru.P1.LexA.Scer\SceI.RS)}

P{fru.C-5'donor}

P{fru.GAL4.GFP.donor}

P{fru.M-5'donor}

P{fru.X-3'donor}

P{fru.Δtra-5'donor}

Insertions

Type of insertions

Name

Expression data

insertion of mobile activating element

P{EPgy2}fru^EY02366

P{EPgy2}fru^EY09280

P{XP}fru^d03344

miscellaneous insertions

insertion of enhancer trap

P{lacW}l(3)SH033^SH033

P{lwB}fru^sat

P{PZ}fru³

P{PZ}fru⁴

insertion of enhancer trap binary system

Mi{ET1}fru^MB01996

Mi{ET1}fru^MB02472

P{GawB}fru^NP0021

Gene Ontology: Function, Process & Cellular Component ( 20 unique terms )

Terms Based on Experimental Evidence ( 13 terms )

Molecular Function ( 0 terms)

Biological Process

CV term

Evidence

References

aggressive behavior