Gene Dmel\fs(1)h

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General Information

Symbol

Dmel\fs(1)h

Species

D. melanogaster

Name

female sterile (1) homeotic

Annotation symbol

CG2252

Feature type

protein_coding_gene

FlyBase ID

FBgn0004656

Created / Updated

2003-12-01/2003-12-01

Genomic Location

Chromosome (arm)

Recombination map

1-21.65

Cytogenetic map

7D3-7D5

Sequence location

X:7,933,976..7,955,469 [-]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

The gene female sterile (1) homeotic is referred to in FlyBase by the symbol fs(1)h (CG2252, FBgn0004656). It has the cytological map location 7D3-7D5. Its sequence location is X:7933976..7955469. Its molecular function is described as: DNA binding; protein kinase activity. It is involved in the biological process regulation of transcription from RNA polymerase II promoter. 33 alleles are reported. The phenotypes of these alleles are annotated with: metathoracic segment; egg; hypostomal sclerite; mouth hooks; embryonic head. It has 5 annotated transcripts and 5 annotated polypeptides.

External Summaries

Phenotypic Description from the Red Book (Lindsley & Zimm 1992)

Gene/Allele symbols may differ from current usage

fs(1)h: female sterile (1) homeotic

Many mutant alleles at this locus are nonconditional lethals, but there are three temperature-sensitive hypomorphic alleles. fs(1)h1 is the weakest of these and many of the phenotypic studies have been carried out on it and on Df(1)C128, which is deficient for the locus. Temperature-sensitive genotypes display two periods of sensitivity to elevated temperature; one is during oogenesis and affects embryonic development and the other is during the pupal stage and affects adult survival. Adult survival of fs(1)h1 homozygotes and fs(1)h1/Df(1)C128 heterozygotes is normal at 20 and 25, but 10% and 0 respectively at 28.5. As mentioned above, the TSP for lethality is the pupal stage. fs(1)h15 shown to be lethal in germ-line clones (Perrimon, Engstrom, and Mahowald, 1984a, Dev. Biol. 105: 404-14). Fertility of fs(1)h homozygotes and fs(1)h/Df(1)C128 temperature sensitive with the former becoming completely sterile at 29 and the latter at 25; temperature-sensitive periods for fs(1)h/Df(1)C128 females during pregastrulation embryogenesis and perhaps late oogenesis. Eggs laid at restrictive temperatures exhibited normal preblastoderm development, although about half the nuclei are haploid; nuclear behavior during blastoderm formation disrupted and development arrested in blastoderm or early gastrulation. Larvae and adults surviving semi-permissive temperatures display homeotic anomalies; dead embryos, and newly hatched larvae frequently have missing thoracic and anterior abdominal segments; surviving adults exhibit a sex ratio skewed in favor of males and frequently show missing halteres and less frequently third legs; effects are more severe in progeny of fs(1)h/Df(1)C128 than homozygous fs(1)h females, in daughters than sons, and at 25 than 23; small areas of homeotic transformations of anterior metathoracic to anterior mesothoracic structures also seen. The maternal effect of fs(1)h interacts synergistically with Ubx130, Df(3R)red, and trx, but not bx3 or pbx.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

7D3-7D5

Limits computationally determined from genome sequence between P{EP}sn^EP1217 and P{EP}Ubc-E2H^EP1303

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

7D5-7D6

There is a discrepancy between the in situ localisation (12C) and the molecular localisation based on the flanking sequence (7D5--7D6) for the "l(1)G0495" (fs(1)h^G0495) line. The available data suggests that it is most likely that the molecular localisation (7D5--7D6) is correct and that the in situs were misinterpreted.