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Gene Dmel\fs(1)h

General Information
Symbol	Dmel\fs(1)h	Species	D. melanogaster
Name	female sterile (1) homeotic	Annotation symbol	CG2252
Feature type	protein_coding_gene	FlyBase ID	FBgn0004656
Gene Model Status	Current	Stock availability	32 publicly available
Also Known As	fsh, fs(1)1456, fs(1)M16
Genomic Location
Chromosome (arm)	X	Recombination map	1-21.65
Cytogenetic map	7D3-7D5	Sequence location	X:7,933,976..7,955,469 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene female sterile (1) homeotic is referred to in FlyBase by the symbol Dmel\fs(1)h (CG2252, FBgn0004656). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: protein kinase activity; DNA binding. There is experimental evidence that it is involved in the biological process: terminal region determination; negative regulation of transcription, DNA-dependent. 53 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/first instar larval cuticle; embryonic head; cephalopharyngeal skeleton; egg; metathoracic segment; mouth hooks; hypostomal sclerite. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: Bromodomain; Bromodomain, conserved site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, larval trachea, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, adult spermathecae, adult male accessory gland, larval/adult carcass. Gene sequence location is X:7933976..7955469.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	fs(1)h: female sterile (1) homeotic Many mutant alleles at this locus are nonconditional lethals, but there are three temperature-sensitive hypomorphic alleles. fs(1)h1 is the weakest of these and many of the phenotypic studies have been carried out on it and on Df(1)C128, which is deficient for the locus. Temperature-sensitive genotypes display two periods of sensitivity to elevated temperature; one is during oogenesis and affects embryonic development and the other is during the pupal stage and affects adult survival. Adult survival of fs(1)h1 homozygotes and fs(1)h1/Df(1)C128 heterozygotes is normal at 20 and 25, but 10% and 0 respectively at 28.5. As mentioned above, the TSP for lethality is the pupal stage. fs(1)h15 shown to be lethal in germ-line clones (Perrimon, Engstrom, and Mahowald, 1984a, Dev. Biol. 105: 404-14). Fertility of fs(1)h homozygotes and fs(1)h/Df(1)C128 temperature sensitive with the former becoming completely sterile at 29 and the latter at 25; temperature-sensitive periods for fs(1)h/Df(1)C128 females during pregastrulation embryogenesis and perhaps late oogenesis. Eggs laid at restrictive temperatures exhibited normal preblastoderm development, although about half the nuclei are haploid; nuclear behavior during blastoderm formation disrupted and development arrested in blastoderm or early gastrulation. Larvae and adults surviving semi-permissive temperatures display homeotic anomalies; dead embryos, and newly hatched larvae frequently have missing thoracic and anterior abdominal segments; surviving adults exhibit a sex ratio skewed in favor of males and frequently show missing halteres and less frequently third legs; effects are more severe in progeny of fs(1)h/Df(1)C128 than homozygous fs(1)h females, in daughters than sons, and at 25 than 23; small areas of homeotic transformations of anterior metathoracic to anterior mesothoracic structures also seen. The maternal effect of fs(1)h interacts synergistically with Ubx130, Df(3R)red, and trx, but not bx3 or pbx.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Carreira et al., 2011, BMC Dev. Biol. 11: 32 Sequence features BKN51107 BKN50119 HFA18778 BKN21636
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 7D3-7D5   Limits computationally determined from genome sequence between P{EP}snEP1217 and P{EP}Ubc-E2HEP1303
Experimentally Determined Cytological Location
Cytogenetic map Notes References 7D3-7D4   (determined by in situ hybridisation)   (Peter et al., 2002) 12C-12C   (determined by in situ hybridisation) 7D3--4 (determined by in situ hybridisation)   (Schaefer et al., 1999.12.2) 7D5-7D6   (determined by in situ hybridisation)   (Haynes et al., 1989) 7D4-7D6   (determined by in situ hybridisation)   (Digan et al., 1986) 7D5-7D6   There is a discrepancy between the in situ localisation (12C) and the molecular localisation based on the flanking sequence (7D5--7D6) for the "l(1)G0495" (fs(1)hG0495) line. The available data suggests that it is most likely that the molecular localisation (7D5--7D6) is correct and that the in situs were misinterpreted.   (Schaefer, 2003.12.4)
Experimentally Determined Recombination Data
Location	1-21.65   1- (Mohler, 1977)
Left of (cM)	mys (Monastirioti et al., 1996) v (Mohler, 1977)
Right of (cM)	cv (Mohler, 1977) sn sws Tbh (Monastirioti et al., 1996)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\fs(1)h for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) fs(1)h-RA FBtr0071118  NM_167144   6052   1110 fs(1)h-RB FBtr0071119  NM_078523   7790   2038 fs(1)h-RC FBtr0071120  NM_206647   5940   1110 fs(1)h-RD FBtr0071121  NM_206646   5933   1110 fs(1)h-RE FBtr0071122  NM_206645   5664   1110 fs(1)h-RF FBtr0301309  NM_001169228   5024   1110
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein fs(1)h-PA   FBpp0071073   110.6   1110   9.83     NP_727228   AAN09226 fs(1)h-PB   FBpp0071074   205.3   2038   9.75     NP_511078   AAF46312 fs(1)h-PC   FBpp0089297   110.6   1110   9.83     NP_996370   AAS65277 fs(1)h-PD   FBpp0089298   110.6   1110   9.83     NP_996369   AAS65278 fs(1)h-PE   FBpp0089299   110.6   1110   9.83     NP_996368   AAS65279 fs(1)h-PF   FBpp0290524   110.6   1110   9.83     NP_001162699   ACZ95234
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Bromodomain, conserved site (IPR018359) Bromodomain (IPR001487)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA390990   AA392953   AA433225   AA538764   AA539770   AA540279   AA541025   AA696733   AA817497   AA940845   AA951157   AA978801   AE014298 AAF46312   AE014298 AAN09226   AE014298 AAS65277   AE014298 AAS65278   AE014298 AAS65279   AE014298 ACZ95234   AI113539   AI124291   AI389996   AI402856   AI402904   AI403425   AI513161   AI513449   AI514343   AI515417   AI515626   AI518439   AI519296   AI534164   AJ426759   AJ426760   AQ025338   AQ025375   AW943496   BG639240   BG639363   BG639687   BH900886   BI242220   BI352452   BI372203   BI628847   BP548650   BP552373   BQ103381   BT015270 AAT94499   BT124880   CK657143   CK658074   CK660885   CL844338   CO179270   CO181064   CO185294   CO188416   CO276593   CO277030   CO281394   CO284848   CO288911   CO290162   CO290358   CO296428   CO296436   CO298265   CO301066   CO308532   CO309648   CO314075   CO320157   CO321535   CO321745   CO322114   CO323208   CO328514   CO335529   CO336551   CO336922   CO338066   CO340669   CO341994   CO345439   CO345531   CZ471033   CZ473514   CZ473830   EC056915   EC058388   EC062884   EC063019   EC065533   EC068206   EC073407   EC083083   EC084381   EC196434   EC200431   EC207655   EC211343   EC211768   EC212012   EC212998   EC213049   EC214150   EC224971   EC226605   EC227551   EC229666   EC230781   EC236899   EC245268   EC247623   EC252224   EC257242   EC258654   EC259775   EC262353   EC266765   EG974100   EL871211   EL871330   EL871331   EL884110   EL884237   EL884238   M15762 AAA70424   M15763 AAA70423   M15764   M23221 AAA28540   M23222 AAA28541   M23223   Z32001   Z32106   Z32313
UniProtKB/Swiss-Prot	P13709
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0004656    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0004656 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0004656 expression level Developmental Stage   Expression Level embryo 00-02hr    4278 embryo 02-04hr    5032 embryo 04-06hr    4048 embryo 06-08hr    4888 embryo 08-10hr    3630 embryo 10-12hr    1866 embryo 12-14hr    2116 embryo 14-16hr    2729 embryo 16-18hr    1986 embryo 18-20hr    1788 embryo 20-22hr    1709 embryo 22-24hr    1471 larva L1    1198 larva L2    822 larva L3 12hr old    907 larva L3 puffstage 1-2    519 larva L3 puffstage 3-6    1482 larva L3 puffstage 7-9    1298 white prepupae new    1366 white prepupae 12hr    1285 white prepupae 24hr    1741 pupae 2d postWPP    1007 pupae 3d postWPP    622 pupae 4d postWPP    758 adult male 01day    740 adult male 05day    932 adult male 30day    959 adult female 01day    2183 adult female 05day    2618 adult female 30day    2935 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4278) embryo 02-04hr  (5032) embryo 04-06hr  (4048) embryo 06-08hr  (4888) embryo 08-10hr  (3630) embryo 10-12hr  (1866) embryo 12-14hr  (2116) embryo 14-16hr  (2729) embryo 16-18hr  (1986) embryo 18-20hr  (1788) embryo 20-22hr  (1709) embryo 22-24hr  (1471) larva L1  (1198) larva L2  (822) larva L3 12hr old  (907) larva L3 puffstage 1-2  (519) larva L3 puffstage 3-6  (1482) larva L3 puffstage 7-9  (1298) white prepupae new  (1366) white prepupae 12hr  (1285) white prepupae 24hr  (1741) pupae 2d postWPP  (1007) pupae 3d postWPP  (622) pupae 4d postWPP  (758) adult male 01day  (740) adult male 05day  (932) adult male 30day  (959) adult female 01day  (2183) adult female 05day  (2618) adult female 30day  (2935) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4278) embryo 02-04hr  (5032) embryo 04-06hr  (4048) embryo 06-08hr  (4888) embryo 08-10hr  (3630) embryo 10-12hr  (1866) embryo 12-14hr  (2116) embryo 14-16hr  (2729) embryo 16-18hr  (1986) embryo 18-20hr  (1788) embryo 20-22hr  (1709) embryo 22-24hr  1471 larva L1    1198 larva L2    822 larva L3 12hr old    907 larva L3 puffstage 1-2    519 larva L3 puffstage 3-6  1482 larva L3 puffstage 7-9    1298 white prepupae new    1366 white prepupae 12hr    1285 white prepupae 24hr  (1741) pupae 2d postWPP    1007 pupae 3d postWPP    622 pupae 4d postWPP    758 adult male 01day    740 adult male 05day    932 adult male 30day    959 adult female 01day  (2183) adult female 05day  (2618) adult female 30day  (2935) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4278 embryo 02-04hr    5032 embryo 04-06hr    4048 embryo 06-08hr    4888 embryo 08-10hr    3630 embryo 10-12hr    1866 embryo 12-14hr    2116 embryo 14-16hr    2729 embryo 16-18hr    1986 embryo 18-20hr    1788 embryo 20-22hr    1709 embryo 22-24hr    1471 larva L1    1198 larva L2    822 larva L3 12hr old    907 larva L3 puffstage 1-2    519 larva L3 puffstage 3-6    1482 larva L3 puffstage 7-9    1298 white prepupae new    1366 white prepupae 12hr    1285 white prepupae 24hr    1741 pupae 2d postWPP    1007 pupae 3d postWPP    622 pupae 4d postWPP    758 adult male 01day    740 adult male 05day    932 adult male 30day    959 adult female 01day    2183 adult female 05day    2618 adult female 30day    2935 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4278 embryo 02-04hr    5032 embryo 04-06hr    4048 embryo 06-08hr    4888 embryo 08-10hr    3630 embryo 10-12hr    1866 embryo 12-14hr    2116 embryo 14-16hr    2729 embryo 16-18hr    1986 embryo 18-20hr    1788 embryo 20-22hr    1709 embryo 22-24hr    1471 larva L1    1198 larva L2    822 larva L3 12hr old    907 larva L3 puffstage 1-2    519 larva L3 puffstage 3-6    1482 larva L3 puffstage 7-9    1298 white prepupae new    1366 white prepupae 12hr    1285 white prepupae 24hr    1741 pupae 2d postWPP    1007 pupae 3d postWPP    622 pupae 4d postWPP    758 adult male 01day    740 adult male 05day    932 adult male 30day    959 adult female 01day    2183 adult female 05day    2618 adult female 30day    2935 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0004656 expression level Developmental Stage   Expression Level embryo 00-02hr    4278 embryo 02-04hr    5032 embryo 04-06hr    4048 embryo 06-08hr    4888 embryo 08-10hr    3630 embryo 10-12hr    1866 embryo 12-14hr    2116 embryo 14-16hr    2729 embryo 16-18hr    1986 embryo 18-20hr    1788 embryo 20-22hr    1709 embryo 22-24hr    1471 larva L1    1198 larva L2    822 larva L3 12hr old    907 larva L3 puffstage 1-2    519 larva L3 puffstage 3-6    1482 larva L3 puffstage 7-9    1298 white prepupae new    1366 white prepupae 12hr    1285 white prepupae 24hr    1741 pupae 2d postWPP    1007 pupae 3d postWPP    622 pupae 4d postWPP    758 adult male 01day    740 adult male 05day    932 adult male 30day    959 adult female 01day    2183 adult female 05day    2618 adult female 30day    2935 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4278) embryo 02-04hr  (5032) embryo 04-06hr  (4048) embryo 06-08hr  (4888) embryo 08-10hr  (3630) embryo 10-12hr  (1866) embryo 12-14hr  (2116) embryo 14-16hr  (2729) embryo 16-18hr  (1986) embryo 18-20hr  (1788) embryo 20-22hr  (1709) embryo 22-24hr  (1471) larva L1  (1198) larva L2  (822) larva L3 12hr old  (907) larva L3 puffstage 1-2  (519) larva L3 puffstage 3-6  (1482) larva L3 puffstage 7-9  (1298) white prepupae new  (1366) white prepupae 12hr  (1285) white prepupae 24hr  (1741) pupae 2d postWPP  (1007) pupae 3d postWPP  (622) pupae 4d postWPP  (758) adult male 01day  (740) adult male 05day  (932) adult male 30day  (959) adult female 01day  (2183) adult female 05day  (2618) adult female 30day  (2935) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4278) embryo 02-04hr  (5032) embryo 04-06hr  (4048) embryo 06-08hr  (4888) embryo 08-10hr  (3630) embryo 10-12hr  1866 embryo 12-14hr  2116 embryo 14-16hr  (2729) embryo 16-18hr  1986 embryo 18-20hr  1788 embryo 20-22hr  1709 embryo 22-24hr  1471 larva L1    1198 larva L2    822 larva L3 12hr old    907 larva L3 puffstage 1-2    519 larva L3 puffstage 3-6  1482 larva L3 puffstage 7-9    1298 white prepupae new    1366 white prepupae 12hr    1285 white prepupae 24hr  1741 pupae 2d postWPP    1007 pupae 3d postWPP    622 pupae 4d postWPP    758 adult male 01day    740 adult male 05day    932 adult male 30day    959 adult female 01day  2183 adult female 05day  (2618) adult female 30day  (2935) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4278 embryo 02-04hr    5032 embryo 04-06hr    4048 embryo 06-08hr    4888 embryo 08-10hr    3630 embryo 10-12hr    1866 embryo 12-14hr    2116 embryo 14-16hr    2729 embryo 16-18hr    1986 embryo 18-20hr    1788 embryo 20-22hr    1709 embryo 22-24hr    1471 larva L1    1198 larva L2    822 larva L3 12hr old    907 larva L3 puffstage 1-2    519 larva L3 puffstage 3-6    1482 larva L3 puffstage 7-9    1298 white prepupae new    1366 white prepupae 12hr    1285 white prepupae 24hr    1741 pupae 2d postWPP    1007 pupae 3d postWPP    622 pupae 4d postWPP    758 adult male 01day    740 adult male 05day    932 adult male 30day    959 adult female 01day    2183 adult female 05day    2618 adult female 30day    2935 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4278 embryo 02-04hr    5032 embryo 04-06hr    4048 embryo 06-08hr    4888 embryo 08-10hr    3630 embryo 10-12hr    1866 embryo 12-14hr    2116 embryo 14-16hr    2729 embryo 16-18hr    1986 embryo 18-20hr    1788 embryo 20-22hr    1709 embryo 22-24hr    1471 larva L1    1198 larva L2    822 larva L3 12hr old    907 larva L3 puffstage 1-2    519 larva L3 puffstage 3-6    1482 larva L3 puffstage 7-9    1298 white prepupae new    1366 white prepupae 12hr    1285 white prepupae 24hr    1741 pupae 2d postWPP    1007 pupae 3d postWPP    622 pupae 4d postWPP    758 adult male 01day    740 adult male 05day    932 adult male 30day    959 adult female 01day    2183 adult female 05day    2618 adult female 30day    2935 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0004656    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0004656 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, larval trachea, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, adult spermathecae, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004656 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2252-RB;CG2252-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for fs(1)h Stages(s) 1-3 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele cell lethal | germline clone fs(1)hh3 lethal fs(1)hG0495 lethal | embryonic stage fs(1)hCXE1 fs(1)hG0093 fs(1)hPA fs(1)hPE fs(1)hrnc lethal | embryonic stage | maternal effect | heat sensitive (with fs(1)h1) fs(1)hPA fs(1)hrnc lethal | embryonic stage | maternal effect | heat sensitive (with fs(1)hPA) fs(1)h1 lethal | embryonic stage | maternal effect | heat sensitive (with fs(1)hrnc) fs(1)h1 lethal | embryonic stage | maternal effect | partially | heat sensitive (with fs(1)h1) fs(1)h4 lethal | embryonic stage | maternal effect | partially | heat sensitive (with fs(1)h4) fs(1)h1 lethal | embryonic stage | recessive fs(1)hrnc lethal | embryonic stage | recessive | rescuable maternal effect fs(1)h6 lethal | heat sensitive fs(1)h1 lethal | heat sensitive (with fs(1)h1) fs(1)h1033B fs(1)hCXE1 lethal | heat sensitive (with fs(1)h1033B) fs(1)h1 lethal | heat sensitive (with fs(1)hCXE1) fs(1)h1 lethal | larval stage fs(1)h15 lethal | larval stage | male fs(1)h3 fs(1)h17 fs(1)h18 lethal | larval stage | recessive fs(1)h4 fs(1)h14 fs(1)hh3 lethal | maternal effect | heat sensitive fs(1)h1 lethal | pupal stage | heat sensitive fs(1)h1 fs(1)h2 fs(1)h6 lethal | recessive fs(1)h17 fs(1)h18 fs(1)hG0093 fs(1)hG0495 lethal | rescuable maternal effect fs(1)h6 viable fs(1)hEY10625 Sterility Allele female sterile | heat sensitive fs(1)h1 fs(1)h4 fs(1)hPA fs(1)hrnc female sterile | heat sensitive (with Df(1)C128) fs(1)h1 female sterile | heat sensitive (with fs(1)h1) fs(1)h4 fs(1)hPA fs(1)hrnc female sterile | heat sensitive (with fs(1)h4) fs(1)h1 female sterile | heat sensitive (with fs(1)hPA) fs(1)h1 female sterile | heat sensitive (with fs(1)hrnc) fs(1)h1 female sterile | maternal effect | recessive | heat sensitive fs(1)h1 fs(1)h2 female sterile | recessive fs(1)h6 fertile fs(1)hEY10625 Phenotype manifest in Allele abdominal segment 2 | maternal effect | heat sensitive (with fs(1)h1) fs(1)h4 fs(1)hrnc fs(1)hPA abdominal segment 2 | maternal effect | heat sensitive (with fs(1)h4) fs(1)h1 abdominal segment 2 | maternal effect | heat sensitive (with fs(1)hPA) fs(1)h1 abdominal segment 2 | maternal effect | heat sensitive (with fs(1)hrnc) fs(1)h1 cephalopharyngeal skeleton fs(1)hrnc fs(1)hPA cephalopharyngeal skeleton | maternal effect | heat sensitive (with fs(1)h1) fs(1)hPA cephalopharyngeal skeleton | maternal effect | heat sensitive (with fs(1)hPA) fs(1)h1 egg fs(1)h6 embryonic/first instar larval cuticle fs(1)hrnc fs(1)hPE fs(1)hPA embryonic/first instar larval cuticle | maternal effect | heat sensitive (with fs(1)h1) fs(1)h4 embryonic/first instar larval cuticle | maternal effect | heat sensitive (with fs(1)h4) fs(1)h1 embryonic head fs(1)hrnc filzkorper | maternal effect | heat sensitive (with fs(1)h1) fs(1)hrnc fs(1)hPA filzkorper | maternal effect | heat sensitive (with fs(1)hPA) fs(1)h1 filzkorper | maternal effect | heat sensitive (with fs(1)hrnc) fs(1)h1 hypostomal sclerite fs(1)hrnc larval head | maternal effect | heat sensitive (with fs(1)h1) fs(1)hrnc larval head | maternal effect | heat sensitive (with fs(1)hrnc) fs(1)h1 metathoracic segment fs(1)h4 fs(1)h6 metathoracic segment | maternal effect fs(1)h1 fs(1)h2 mouth hooks fs(1)hrnc
Classical Alleles ( 50 )
For All Classical Alleles Show
Allele of fs(1)h Class Mutagen Stocks Known lesion fs(1)h18 PM hybrid dysgenesis MR MRh12 2 Yes fs(1)h1 ethyl methanesulfonate 2 Yes fs(1)h4 ethyl methanesulfonate diepoxybutane 2 Yes fs(1)hG0093 P-element activity 2 -- fs(1)hG0495 P-element activity 2 -- fs(1)hrnc antimorphic allele - genetic evidence ethyl methanesulfonate 2 Yes fs(1)hCB-0428-3 1 -- fs(1)hd03703 P-element activity 1 -- fs(1)hd04280 P-element activity 1 -- fs(1)hEP439 P-element activity 1 -- fs(1)hEY03938 P-element activity 1 -- fs(1)hEY10625 P-element activity 1 -- fs(1)hf00220 1 -- fs(1)hGS1147 1 Yes fs(1)hGS5099 1 Yes fs(1)hKG06011 P-element activity 1 -- fs(1)hNP0717 1 -- fs(1)hNP1020 1 -- fs(1)hNP1101 1 -- fs(1)hNP2065 1 -- fs(1)hNP6116 1 -- fs(1)hNP7115 1 -- fs(1)h1033B Delta2-3 0 Yes fs(1)h10 X ray 0 -- fs(1)h11 ethyl methanesulfonate 0 -- fs(1)h12 ethyl methanesulfonate 0 -- fs(1)h13 ethyl methanesulfonate 0 -- fs(1)h14 ethyl methanesulfonate 0 -- fs(1)h15 ethyl methanesulfonate 0 -- fs(1)h16 ethyl methanesulfonate 0 -- fs(1)h17 spontaneous 0 Yes fs(1)h2 ethyl methanesulfonate 0 -- fs(1)h3 ethyl methanesulfonate 0 -- fs(1)h5-HA-2187 0 -- fs(1)h5 PM hybrid dysgenesis 0 -- fs(1)h6 ethyl methanesulfonate 0 -- fs(1)h7 X ray 0 -- fs(1)h8 X ray 0 Yes fs(1)h9 X ray 0 -- fs(1)hc06857 piggyBac transposase 0 -- fs(1)hCPTI001383 piggyBac transposase 0 Yes fs(1)hcx20.8 0 Yes fs(1)hCXE1 Delta2-3 0 Yes fs(1)hEP1033 P-element activity 0 -- fs(1)hGG01199 0 -- fs(1)hGG01481 0 -- fs(1)hh3 0 -- fs(1)hNP4077 0 -- fs(1)hPA Delta2-3 0 Yes fs(1)hPE Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of fs(1)h Class Mutagen Stocks Known lesion fs(1)hGD4452 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes fs(1)hGL00006 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes fs(1)hKK101585 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(1)C128 (Zheng et al., 2003, Eeken et al., 1985, Digan et al., 1986, Shearn, 1989, Monastirioti et al., 1996, Florence and Faller, 2008) Df(1)CXE1 (Florence and Faller, 2008) Df(1)Desi-S3 (Florence and McGinnis, 1998, Zheng et al., 2003) Df(1)hl-a (Zheng et al., 2003) Df(1)PE (Florence and Faller, 2008) Df(1)RA2 (Schalet, 1986)
Duplicated in	Dp(1;2)sn+72d (Florence and McGinnis, 1998, Eeken et al., 1985, Monastirioti et al., 1996, Florence and Faller, 2008)
Not disrupted in	Df(1)C128 (Florence and McGinnis, 1998) Df(1)ct4b1 (Eeken et al., 1985) Df(1)ct-J4 (Florence and McGinnis, 1998, Eeken et al., 1985) Df(1)GE202 (Florence and McGinnis, 1998, Zheng et al., 2003) Df(1)HA11 (Florence and McGinnis, 1998) Df(1)KA14 (Florence and McGinnis, 1998) Df(1)RA2 (Florence and McGinnis, 1998, Zheng et al., 2003, Eeken et al., 1985) Df(1)Sp8A (Schalet, 1986)
Not duplicated in	Dp(1;3)sn13a1 (Florence and McGinnis, 1998, Eeken et al., 1985)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4452} NA P{KK101585} NA P{TRiP.GL00006} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}fs(1)hEP439 NA P{EP}fs(1)hEP1033 NA P{EPgy2}fs(1)hEY03938 NA P{EPgy2}fs(1)hEY10625 NA P{GSV1}fs(1)hGS1147 NA P{GSV2}fs(1)hGS5099 NA P{Mae-UAS.6.11}fs(1)hGG01199 NA P{Mae-UAS.6.11}fs(1)hGG01481 NA P{XP}fs(1)hd03703 NA P{XP}fs(1)hd04280 NA miscellaneous insertions copia{}fs(1)h17 NA P{CaSpeR}fs(1)hcx20.8 NA P{RS3}fs(1)hCB-0428-3 NA P{RS5}fs(1)h5-HA-2187 NA P{SUPor-P}fs(1)hKG06011 NA PBac{681.P.FSVS-1}fs(1)hCPTI001383 NA PBac{PB}fs(1)hc06857 NA PBac{WH}fs(1)hf00220 NA insertion of enhancer trap binary system P{GawB}fs(1)hNP0717 No P{GawB}fs(1)hNP1020 No P{GawB}fs(1)hNP1101 No P{GawB}fs(1)hNP2065 No P{GawB}fs(1)hNP4077 No P{GawB}fs(1)hNP6116 No P{GawB}fs(1)hNP7115 No insertion of enhancer trap P{lacW}fs(1)hG0093 No P{lacW}fs(1)hG0495 No
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
negative regulation of transcription, DNA-dependent inferred from mutant phenotype (Florence and Faller, 2008) terminal region determination inferred from mutant phenotype (Florence and Faller, 2008)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
DNA binding non-traceable author statement (Swiss-Prot Project Members, 1990.1.1) protein kinase activity non-traceable author statement (Manning, 2002.11.16)
Biological Process
CV term Evidence References
regulation of transcription from RNA polymerase II promoter non-traceable author statement (Swiss-Prot Project Members, 1990.1.1)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions fs(1)h allele Gene References fs(1)h1 ash2 (Shearn, 1989) trx (Shearn, 1989) fs(1)hTA54 Dfd (Florence and McGinnis, 1998) unspecified ash1 (Shearn, 1989) pbl (Gregory et al., 2007)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58193 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0004656 DroID - A comprehensive database of gene and protein interactions. • FBgn0004656 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31722
Orthologs
Genome-wide drosophilid orthologs	Dere\GG17589 Dgri\GH17935 Dmoj\GI15407 Dper\GL14811 Dpse\GA26201 Dsec\GM11218 Dsim\GD16134 Dwil\GK15212 Dyak\GE17489
Curated drosophilid orthologs	Dpse\GA15323
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AGAP002807-PA Anopheles gambiae (mosquito) XP_624214.2 Apis mellifera (honey bee) XP_001944541.1 Acyrthosiphon pisum (pea aphid) 128954 Branchiostoma floridae (lancelet) XP_001896320.1 Brugia malayi (roundworm nematode) ENSBTAP00000013992 Bos taurus (bovine) CAL0003781 Candida albicans (a form of yeast) CE42644 Caenorhabditis elegans (worm) ENSCAFP00000029360 Canis familiaris (dog) Chro.70137 Cryptosporidium hominis (obligate parasite) cgd7_1130 Cryptosporidium parvum (protozoan parasite) CPIJ004311 Culex pipens (mosquito) ENSCPOP00000001274 Cavia porcellus (guinea pig) RP05652 Caenorhabditis remanei (nematode) 169335 Capitella spl (polychaete worm) 302185 Daphnia pulex (daphnia) ENSDARP00000038787 Danio rerio (zebra fish) ENSECAP00000019958 Equus caballus (horse) ENSGACP00000013356 Gymnopilus aculeatus (mushroom) ENSGALP00000009694 Gallus gallus (chicken) 191322 Hypsipyla robusta (cedar shoot borer) ENSP00000263377 Homo sapiens (human) ISCW010077-PA Ixodes scapularis (deer tick) ENSMODP00000018187 Monodelphis domestica (gray opossum) ENSMMUP00000028168 Macaca mulatta (rhesus monkey) ENSMUSP00000003726 Mus musculus (house mouse) XP_001603224.1 Nasonia vitripennis (wasp) ENSOANP00000004526 Ornithorynchus anatinus (platypus) ENSORLP00000008239 Oryzias latipes (japanese killifish) ENSPPYP00000010837 Pongo pygmaeus (orangutan) 143063 Phytophthora sojae (root rot pathogen) ENSPTRP00000018122 Pan troglodytes (chimpanzee) PVX_081275 Plasmodium vivax (protozoal parasite) ENSRNOP00000057094 Rattus norvegicus (norway rat) YDL070W Saccharomyces cerevisiae (budding yeast) Smp_147950 Schistosoma mansoni (trematode parasite) XP_001185640.1 Strongylocentrotus purpuratus (purple sea urchin) XP_967957.2 Tribolium castaneum (red flour beetle) ENSTNIP00000006103 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000037735 Takifugu rubripes (pufferfish Takifugu) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14571 LH13398 ISCW010077 FBgn0234952 FBgn0229382 FBgn0221579 FBgn0208100 FBgn0203549 FBgn0196374 FBgn0170479 JGI_V11_27648 JGI_V11_261209 JGI_V11_302185 JGI_V11_266525 FBgn0247576 FBgn0247368 FBgn0075847 FBgn0071472 FBgn0157118 FBgn0152415 FBgn0148889 FBgn0143850 FBgn0138156 FBgn0050417 FBgn0130503 FBgn0129876 FBgn0129874 FBgn0129873 FBgn0129731 FBgn0125405 FBgn0125403 FBgn0112245 FBgn0109813 FBgn0097994 FBgn0090330 CPIJ004311 ACYPI005684 GB15224 AAEL002125 AAEL002090 PB25076 PHUM211000 GLEAN_11178
Stocks & Reagents
Stocks Listed in FlyBase ( 32 )
Bloomington	5285 fs(1)h18/FM7c 10097 w1118 P{EP}fs(1)hEP439 14600 y1 P{SUPor-P}fs(1)hKG06011 5278 C(1;YL)1, y1 fs(1)hrnc/FM7c 5286 sn3 fs(1)h4 v1/FM0
Harvard	- P{XP}fs(1)hd03703 - P{XP}fs(1)hd04280 - PBac{WH}fs(1)hf00220
Kyoto	108151 fs(1)h18/FM7c
VDRC	v108662 P{KK101585}VIE-260B v51227 w1118; P{GD4452}v51227 v51305 w1118; P{GD4452}v51305
	More stocks available...
Genomic Clones ( 1 )
	BACR24A02 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 110 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD26482
Other clones	DPiM_LD26482 MIP08027
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH09871 GH21435 GH22177 GH22237 GH22859 GM08283 GM19324 LD09917 LD12150 LD18103 LD18365 LD19720 LD20802 LD23113 LD23123 LD31478 LD32962 LD37947 LD38832 LD45355 LD45725 LD47239 LD47523 LD47763 LP06130 LP14617 LP19832 LP23216 RE39496 RE59104 RH57606 SD04422 SD06685
Other clones	696 33952 41884 42282 54645 59904 60725 60729 61704 64189 79648 80445 80471 84096 103613 108810 119229 155808 177426 214247.16 214275.27 214317.20 214477.18 542457 557977 AA433225 AI124291 CK01.3B.C4 CK01.44C.C3 CK01.75B.F11 CK01.88B.D10 CK01.94A.H1 CK01.94D.F12 CK01.112C.E1 EC13443 EK007632 EK040047 EK058924 EK069645 EK073229 EK073756 EK121521 EK122708 EK157038 EK167003 EK172643 EK180012 EK185853 EK186308 EK187244 EK189943 EK213622 EK213638 EK218722 EK234936 EK258626 EK282543 EN10643 EN12743 EN13504 EN15902 EP09332 EP11108 EP13610 EP22045 EP22228 FGM001A05 FGM218D05 IP03346 IP03446 IP15470 IP15570 LD40160 UUGC0785
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004656 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31722
Antibody Information
Other Information
Discoverer
Etymology
	Named "rancor" after a (mythological) animal from (fictitious) Tatooine with a similar phenotype. (Florence and McGinnis, 1998)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: fs(1)h CG2252 (Zhang, 1999.11)
Source for database merge of	Source for merge of: fs(1)h anon-EST:fe1G2 (FlyBase, 1996-) Source for merge of: fs(1)h l(1)G0093 l(1)G0495 (Peter et al., 2002) Source for merge of: fs(1)h rnc (Florence et al., 2001)
Additional comments	Source for merge of fs(1)h anon-EST:fe1G2 was sequence comparison (date:030707). (FlyBase, 1996-)
Other Comments
	When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of S phase cells, and/or aneuploidy, an increase in the proportion of G2/M phase cells, a decrease in mitotic index, a decrease in cytokinetic index and a decrease in the ratio of cells in prometaphase and metaphase versus the total number of mitotic cells are seen. (Bettencourt-Dias et al., 2004) "7D5--6" was stated as revision. (Schaefer, 2003.12.4) Used in an investigation to address the relationship between retrotransposons and retroviruses and the coadaptation of these retroelements to their host genomes. Results indicate retrotransposons are heterogeneous in contrast to retroviruses, suggesting different modes of evolution by slippage-like mechanisms. (Terzian et al., 1997) A protein sequence motif called the bromodomain has been found in fs(1)h and brm. (Haynes et al., 1992) Fertility of fs(1)h homozygotes and fs(1)h/Df(1)C128 temperature-sensitive with the former becoming completely sterile at 29oC and the latter at 25oC; temperature-sensitive periods for fs(1)h/Df(1)C128 females during pregastrulation embryogenesis and perhaps late oogenesis. Eggs laid at restrictive temperatures exhibited normal preblastoderm development, although about half the nuclei are haploid; nuclear behavior during blastoderm formation disrupted and development arrested in blastoderm or early gastrulation. Larvae and adults surviving semi-permissive temperatures display homeotic anomalies; dead embryos and newly hatched larvae frequently have missing thoracic and anterior abdominal segments; surviving adults exhibit a sex ratio skewed in favor of males and frequently show missing halteres and less frequently third legs; effects are more severe in progeny of fs(1)h/Df(1)C128 than homozygous fs(1)h females, in daughters than sons and at 25oC than 23oC; small areas of homeotic transformations of anterior metathoracic to anterior mesothoracic structures also seen. The maternal effect of fs(1)h interacts synergistically with Ubx130, Df(3R)red1 and trx, but not Ubxbx-3 or Ubx. Most alleles are nonconditional lethals; fine structure mapping places two nonconditional alleles tested distal to the three tested conditional alleles. (Lindsley and Zimm, 1992) Ubx, Kr and eve expression are altered in fs(1)h mutant embryos. Defects in the segmental organisation in fs(1)h-deficient progeny are mediated primarily, but not exclusively, through a restriction in the Kr expression domain. (Huang and Dawid, 1990) Immunocytochemical staining demonstrates that fs(1)h is involved in establishment of a correct expression pattern for Kr, eve, en and Ubx. (Huang and Dawid, 1989) Interactions with a mutation of the fs(1)h homeotic gene were used to confirm that ash1 and ash2 are members of a functionally related group of genes whose alleles have similar transformation properties to mutations of trx. (Shearn, 1989) The temperature sensitive period for lethality is the pupal stage. (Perrimon et al., 1984)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078523 NM_167144 NM_206645 NM_206646 NM_206647 NM_001169228 RefSeq (Proteins) • NP_511078 NP_727228 NP_996368 NP_996369 NP_996370 NP_001162699 DDBJ / EMBL / GenBank • AA433225 AAA28540 AAA28541 AAA70422 AAA70423 AAA70424 AAF46312 AAN09226 AAS65277 AAS65278 AAS65279 AAT94499 ACZ95234 AI124291 AI514343 AJ426759 AJ426760 AQ025338 AQ025375 AW943496 BH900886 BT015270 CL844338 CZ471033 CZ473514 CZ473830 M15762 M15763 M15764 M23221 M23222 M23223 Z32001 Z32106 Z32313 Entrez Gene - A searchable database of RefSeq genes. • 31722 UniProtKB/Swiss-Prot • P13709
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Bromodomain, conserved site (IPR018359) Bromodomain (IPR001487)
Linkouts
	BioGRID - A database of protein and genetic interactions • 58193 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0004656 DroID - A comprehensive database of gene and protein interactions. • FBgn0004656 DRSC - Results from RNAi screens. • FBgn0004656 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004656 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2252-RB;CG2252-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004656 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31722 InParanoid A subset of ortholog calls from InParanoid. • AGAP002807-PA Anopheles gambiae (mosquito) XP_624214.2 Apis mellifera (honey bee) XP_001944541.1 Acyrthosiphon pisum (pea aphid) 128954 Branchiostoma floridae (lancelet) XP_001896320.1 Brugia malayi (roundworm nematode) ENSBTAP00000013992 Bos taurus (bovine) CAL0003781 Candida albicans (a form of yeast) CE42644 Caenorhabditis elegans (worm) ENSCAFP00000029360 Canis familiaris (dog) Chro.70137 Cryptosporidium hominis (obligate parasite) cgd7_1130 Cryptosporidium parvum (protozoan parasite) CPIJ004311 Culex pipens (mosquito) ENSCPOP00000001274 Cavia porcellus (guinea pig) RP05652 Caenorhabditis remanei (nematode) 169335 Capitella spl (polychaete worm) 302185 Daphnia pulex (daphnia) ENSDARP00000038787 Danio rerio (zebra fish) ENSECAP00000019958 Equus caballus (horse) ENSGACP00000013356 Gymnopilus aculeatus (mushroom) ENSGALP00000009694 Gallus gallus (chicken) 191322 Hypsipyla robusta (cedar shoot borer) ENSP00000263377 Homo sapiens (human) ISCW010077-PA Ixodes scapularis (deer tick) ENSMODP00000018187 Monodelphis domestica (gray opossum) ENSMMUP00000028168 Macaca mulatta (rhesus monkey) ENSMUSP00000003726 Mus musculus (house mouse) XP_001603224.1 Nasonia vitripennis (wasp) ENSOANP00000004526 Ornithorynchus anatinus (platypus) ENSORLP00000008239 Oryzias latipes (japanese killifish) ENSPPYP00000010837 Pongo pygmaeus (orangutan) 143063 Phytophthora sojae (root rot pathogen) ENSPTRP00000018122 Pan troglodytes (chimpanzee) PVX_081275 Plasmodium vivax (protozoal parasite) ENSRNOP00000057094 Rattus norvegicus (norway rat) YDL070W Saccharomyces cerevisiae (budding yeast) Smp_147950 Schistosoma mansoni (trematode parasite) XP_001185640.1 Strongylocentrotus purpuratus (purple sea urchin) XP_967957.2 Tribolium castaneum (red flour beetle) ENSTNIP00000006103 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000037735 Takifugu rubripes (pufferfish Takifugu) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/femalesthom.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31722 modMine - Data generated by the modENCODE project. • FBgn0004656 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14571 LH13398 ISCW010077 FBgn0234952 FBgn0229382 FBgn0221579 FBgn0208100 FBgn0203549 FBgn0196374 FBgn0170479 JGI_V11_27648 JGI_V11_261209 JGI_V11_302185 JGI_V11_266525 FBgn0247576 FBgn0247368 FBgn0075847 FBgn0071472 FBgn0157118 FBgn0152415 FBgn0148889 FBgn0143850 FBgn0138156 FBgn0050417 FBgn0130503 FBgn0129876 FBgn0129874 FBgn0129873 FBgn0129731 FBgn0125405 FBgn0125403 FBgn0112245 FBgn0109813 FBgn0097994 FBgn0090330 CPIJ004311 ACYPI005684 GB15224 AAEL002125 AAEL002090 PB25076 PHUM211000 GLEAN_11178
Synonyms & Secondary IDs ( 23 )
Reported As
Symbol Synonym	anon-EST:fe1G2   anon-EST:Liang-1.81   CG2252 (Ida et al., 2009, Keleman et al., 2009.8.5, Ni et al., 2011.7.19) clone 1.81 (Liang and Biggin, 1998) fs(1)26/26A   fs(1)1456 (Foe et al., 1993, Perrimon et al., 1986, Mohler and Carroll, 1984) fs(1)h (Gregory et al., 2007, Chang et al., 2007, Florence and Faller, 2008, Ayroles et al., 2009, Ida et al., 2009, Popodi et al., 2010-, Florence, 2010.5.7, Maia et al., 2007) Fs(1)hL (Florence and Faller, 2008) Fs(1)hS (Florence and Faller, 2008) fs(1)M16 (Perrimon et al., 1986, Mohler and Carroll, 1984, Mohler, 1977) fs(1)R10.4   fsh (Florence et al., 2001, Huang et al., 1999, Papoulas et al., 1998, Terzian et al., 1997, Huang et al., 1996, Lin et al., 1997, Denis and Green, 1996, Huang et al., 1995, Muchardt and Yaniv, 1993, Haynes et al., 1992, Huang and Dawid, 1990, Haynes et al., 1989, ) fst(1)h (Madueno et al., 1995) l(1)7Da (Zheng et al., 2003, ) l(1)G0093 (Schaefer et al., 1999.12.2, ) l(1)G0495 (Schaefer et al., 1999.12.2, ) N72 (Schalet, 1986) ORE-1 (Maia et al., 2007) rnc (Florence and McGinnis, 1998, )
Name Synonym	anon-fast-evolving-1G2   female sterile (1) homeotic (Chang et al., 2007, Florence and Faller, 2008) female sterile (1) homoeotic   rancor (Florence and McGinnis, 1998)
Secondary FlyBase IDs
	FBgn0000809 FBgn0001447 FBgn0025246 FBgn0025884 FBgn0040137 FBgn0040199
References ( 81 )
Generate a list of	All references relating to this gene ( 81 )
List References by type	Research paper  ( 43 ) Supplementary material  ( 3 ) Review  ( 5 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 8 ) FlyBase analysis  ( 3 ) Curated genome annotation  ( 2 ) Book  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 5 ) Automatic genome annotation  ( 1 )
Recent research papers ( 1 )
	Carreira et al., 2011, BMC Dev. Biol. 11: 32 Genetic basis of wing morphogenesis in Drosophila: sexual dimorphism and non-allometric effects of shape variation. [FBrf0214273] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...