A Database of Drosophila Genes & Genomes

FB2012_01, released January 20th, 2012
 

Gene Dmel\fs(1)h

General Information
SymbolDmel\fs(1)hSpeciesD. melanogaster
Namefemale sterile (1) homeoticAnnotation symbolCG2252
Feature typeprotein_coding_geneFlyBase IDFBgn0004656
Gene Model StatusCurrent Stock availability 32 publicly available
Also Known Asfsh, fs(1)1456, fs(1)M16
Genomic Location
Chromosome (arm)XRecombination map1-21.65
Cytogenetic map7D3-7D5Sequence locationX:7,933,976..7,955,469 [-]

Genomic Maps

GBrowse View Help
modENCODE GBrowse
detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
The gene female sterile (1) homeotic is referred to in FlyBase by the symbol Dmel\fs(1)h (CG2252, FBgn0004656). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: protein kinase activity; DNA binding. There is experimental evidence that it is involved in the biological process: terminal region determination; negative regulation of transcription, DNA-dependent. 53 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/first instar larval cuticle; embryonic head; cephalopharyngeal skeleton; egg; metathoracic segment; mouth hooks; hypostomal sclerite. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: Bromodomain; Bromodomain, conserved site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, larval trachea, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, adult spermathecae, adult male accessory gland, larval/adult carcass. Gene sequence location is X:7933976..7955469.

External Summaries
hide Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage
fs(1)h: female sterile (1) homeotic
Many mutant alleles at this locus are nonconditional lethals, but there are three temperature-sensitive hypomorphic alleles. fs(1)h1 is the weakest of these and many of the phenotypic studies have been carried out on it and on Df(1)C128, which is deficient for the locus. Temperature-sensitive genotypes display two periods of sensitivity to elevated temperature; one is during oogenesis and affects embryonic development and the other is during the pupal stage and affects adult survival. Adult survival of fs(1)h1 homozygotes and fs(1)h1/Df(1)C128 heterozygotes is normal at 20 and 25, but 10% and 0 respectively at 28.5. As mentioned above, the TSP for lethality is the pupal stage. fs(1)h15 shown to be lethal in germ-line clones (Perrimon, Engstrom, and Mahowald, 1984a, Dev. Biol. 105: 404-14). Fertility of fs(1)h homozygotes and fs(1)h/Df(1)C128 temperature sensitive with the former becoming completely sterile at 29 and the latter at 25; temperature-sensitive periods for fs(1)h/Df(1)C128 females during pregastrulation embryogenesis and perhaps late oogenesis. Eggs laid at restrictive temperatures exhibited normal preblastoderm development, although about half the nuclei are haploid; nuclear behavior during blastoderm formation disrupted and development arrested in blastoderm or early gastrulation. Larvae and adults surviving semi-permissive temperatures display homeotic anomalies; dead embryos, and newly hatched larvae frequently have missing thoracic and anterior abdominal segments; surviving adults exhibit a sex ratio skewed in favor of males and frequently show missing halteres and less frequently third legs; effects are more severe in progeny of fs(1)h/Df(1)C128 than homozygous fs(1)h females, in daughters than sons, and at 25 than 23; small areas of homeotic transformations of anterior metathoracic to anterior mesothoracic structures also seen. The maternal effect of fs(1)h interacts synergistically with Ubx130, Df(3R)red, and trx, but not bx3 or pbx.
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Description
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What does this section not display?
This section does not currently display links that were removed or gene model changes.
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FB2012_01
References
Sequence features
FB2011_10
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
7D3-7D5  
Limits computationally determined from genome sequence between P{EP}snEP1217 and P{EP}Ubc-E2HEP1303  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
7D3-7D4  
(determined by in situ hybridisation)  
12C-12C  
(determined by in situ hybridisation) 7D3--4 (determined by in situ hybridisation)  
7D5-7D6  
(determined by in situ hybridisation)  
7D4-7D6  
(determined by in situ hybridisation)  
7D5-7D6  
There is a discrepancy between the in situ localisation (12C) and the molecular localisation based on the flanking sequence (7D5--7D6) for the "l(1)G0495" (fs(1)hG0495) line. The available data suggests that it is most likely that the molecular localisation (7D5--7D6) is correct and that the in situs were misinterpreted.  
Experimentally Determined Recombination Data
Location
1-21.65
 
Left of (cM)
Right of (cM)
Notes
hide Gene Model & Products
Please see the GBrowse view of Dmel\fs(1)h for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
detailed view FBtr0071119 FBtr0071122 FBtr0301309 FBtr0071121 FBtr0071120 FBtr0071118 FBtr0071105 FBpp0089298 FBpp0071073 FBpp0089297 FBpp0089299 FBpp0290524 FBpp0071074 FBti0143938 FBti0015686 FBti0071576 FBti0108626 FBti0037232 FBti0108187 FBti0066320 FBti0034587 FBti0035681 FBti0028105 FBti0077091 FBti0049152 FBti0024538 FBti0058872 FBti0071855 FBti0036824 FBti0034180 FBti0111161 FBti0033864 FBti0038083 FBti0055479 FBti0055292 FBti0077090 FBti0034119 FBti0007313 FBti0007355 FBti0040123 FBti0054224 FBti0018655 FBti0013939
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
FBtr0071118
  6052
  1110
FBtr0071119
  7790
  2038
FBtr0071120
  5940
  1110
FBtr0071121
  5933
  1110
FBtr0071122
  5664
  1110
FBtr0301309
  5024
  1110
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
FBpp0071073  
110.6  
1110  
9.83  
FBpp0071074  
205.3  
2038  
9.75  
FBpp0089297  
110.6  
1110  
9.83  
FBpp0089298  
110.6  
1110  
9.83  
FBpp0089299  
110.6  
1110  
9.83  
FBpp0290524  
110.6  
1110  
9.83  
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
Bromodomain (IPR001487)
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
 
 
 
 
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
hide Mapped Features
Mapped Features have been reorganized, please see this article for details.
Additional mapped features and mutations can be found on GBrowse or related reports.
Type
Symbol & Location
Additional Notes
References
hide External Data
Linkouts
Crossreferences
hide Expression Data
hideTranscript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
hidePolypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
hide High-Throughput Expression Data
or
Untitled Document detailed view fs(1)h-RB fs(1)h-RE fs(1)h-RF fs(1)h-RD fs(1)h-RC fs(1)h-RA mys-RA
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

modENCODE Temporal Expression Data for FBgn0004656


   Styles
Linear
Logarithmic
Heatmap
   Scales
max expr for FBgn0004656
Very low expression bin max
Moderate expression bin max
High expression bin max
Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages.
[download data (TSV)]

Guide to modENCODE expression level colors
 
No expression (0 - 0)
 
Extremely low expression (1 - 10)
 
Very low expression (11 - 100)
 
Low expression (101 - 400)
 
Moderate expression (401 - 1400)
 
Moderately high expression (1401 - 4000)
 
High expression (4001 - 10000)
 
Very high expression (10001 - 100000)
 
Extremely high expression (100001 - 2000000)

Linear, scaled to maximum FBgn0004656 expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 4278
embryo 02-04hr
 
 5032
embryo 04-06hr
 
 4048
embryo 06-08hr
 
 4888
embryo 08-10hr
 
 3630
embryo 10-12hr
 
 1866
embryo 12-14hr
 
 2116
embryo 14-16hr
 
 2729
embryo 16-18hr
 
 1986
embryo 18-20hr
 
 1788
embryo 20-22hr
 
 1709
embryo 22-24hr
 
 1471
larva L1
 
 1198
larva L2
 
 822
larva L3 12hr old
 
 907
larva L3 puffstage 1-2
 
 519
larva L3 puffstage 3-6
 
 1482
larva L3 puffstage 7-9
 
 1298
white prepupae new
 
 1366
white prepupae 12hr
 
 1285
white prepupae 24hr
 
 1741
pupae 2d postWPP
 
 1007
pupae 3d postWPP
 
 622
pupae 4d postWPP
 
 758
adult male 01day
 
 740
adult male 05day
 
 932
adult male 30day
 
 959
adult female 01day
 
 2183
adult female 05day
 
 2618
adult female 30day
 
 2935
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
Linear, scaled to Very low expression
Developmental Stage   Expression Level
embryo 00-02hr
 (4278)
embryo 02-04hr
 (5032)
embryo 04-06hr
 (4048)
embryo 06-08hr
 (4888)
embryo 08-10hr
 (3630)
embryo 10-12hr
 (1866)
embryo 12-14hr
 (2116)
embryo 14-16hr
 (2729)
embryo 16-18hr
 (1986)
embryo 18-20hr
 (1788)
embryo 20-22hr
 (1709)
embryo 22-24hr
 (1471)
larva L1
 (1198)
larva L2
 (822)
larva L3 12hr old
 (907)
larva L3 puffstage 1-2
 (519)
larva L3 puffstage 3-6
 (1482)
larva L3 puffstage 7-9
 (1298)
white prepupae new
 (1366)
white prepupae 12hr
 (1285)
white prepupae 24hr
 (1741)
pupae 2d postWPP
 (1007)
pupae 3d postWPP
 (622)
pupae 4d postWPP
 (758)
adult male 01day
 (740)
adult male 05day
 (932)
adult male 30day
 (959)
adult female 01day
 (2183)
adult female 05day
 (2618)
adult female 30day
 (2935)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
Linear, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 (4278)
embryo 02-04hr
 (5032)
embryo 04-06hr
 (4048)
embryo 06-08hr
 (4888)
embryo 08-10hr
 (3630)
embryo 10-12hr
 (1866)
embryo 12-14hr
 (2116)
embryo 14-16hr
 (2729)
embryo 16-18hr
 (1986)
embryo 18-20hr
 (1788)
embryo 20-22hr
 (1709)
embryo 22-24hr
 1471
larva L1
 
 1198
larva L2
 
 822
larva L3 12hr old
 
 907
larva L3 puffstage 1-2
 
 519
larva L3 puffstage 3-6
 1482
larva L3 puffstage 7-9
 
 1298
white prepupae new
 
 1366
white prepupae 12hr
 
 1285
white prepupae 24hr
 (1741)
pupae 2d postWPP
 
 1007
pupae 3d postWPP
 
 622
pupae 4d postWPP
 
 758
adult male 01day
 
 740
adult male 05day
 
 932
adult male 30day
 
 959
adult female 01day
 (2183)
adult female 05day
 (2618)
adult female 30day
 (2935)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 4278
embryo 02-04hr
 
 5032
embryo 04-06hr
 
 4048
embryo 06-08hr
 
 4888
embryo 08-10hr
 
 3630
embryo 10-12hr
 
 1866
embryo 12-14hr
 
 2116
embryo 14-16hr
 
 2729
embryo 16-18hr
 
 1986
embryo 18-20hr
 
 1788
embryo 20-22hr
 
 1709
embryo 22-24hr
 
 1471
larva L1
 
 1198
larva L2
 
 822
larva L3 12hr old
 
 907
larva L3 puffstage 1-2
 
 519
larva L3 puffstage 3-6
 
 1482
larva L3 puffstage 7-9
 
 1298
white prepupae new
 
 1366
white prepupae 12hr
 
 1285
white prepupae 24hr
 
 1741
pupae 2d postWPP
 
 1007
pupae 3d postWPP
 
 622
pupae 4d postWPP
 
 758
adult male 01day
 
 740
adult male 05day
 
 932
adult male 30day
 
 959
adult female 01day
 
 2183
adult female 05day
 
 2618
adult female 30day
 
 2935
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 4278
embryo 02-04hr
 
 5032
embryo 04-06hr
 
 4048
embryo 06-08hr
 
 4888
embryo 08-10hr
 
 3630
embryo 10-12hr
 
 1866
embryo 12-14hr
 
 2116
embryo 14-16hr
 
 2729
embryo 16-18hr
 
 1986
embryo 18-20hr
 
 1788
embryo 20-22hr
 
 1709
embryo 22-24hr
 
 1471
larva L1
 
 1198
larva L2
 
 822
larva L3 12hr old
 
 907
larva L3 puffstage 1-2
 
 519
larva L3 puffstage 3-6
 
 1482
larva L3 puffstage 7-9
 
 1298
white prepupae new
 
 1366
white prepupae 12hr
 
 1285
white prepupae 24hr
 
 1741
pupae 2d postWPP
 
 1007
pupae 3d postWPP
 
 622
pupae 4d postWPP
 
 758
adult male 01day
 
 740
adult male 05day
 
 932
adult male 30day
 
 959
adult female 01day
 
 2183
adult female 05day
 
 2618
adult female 30day
 
 2935
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
log, scaled to maximum FBgn0004656 expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 4278
embryo 02-04hr
 
 5032
embryo 04-06hr
 
 4048
embryo 06-08hr
 
 4888
embryo 08-10hr
 
 3630
embryo 10-12hr
 
 1866
embryo 12-14hr
 
 2116
embryo 14-16hr
 
 2729
embryo 16-18hr
 
 1986
embryo 18-20hr
 
 1788
embryo 20-22hr
 
 1709
embryo 22-24hr
 
 1471
larva L1
 
 1198
larva L2
 
 822
larva L3 12hr old
 
 907
larva L3 puffstage 1-2
 
 519
larva L3 puffstage 3-6
 
 1482
larva L3 puffstage 7-9
 
 1298
white prepupae new
 
 1366
white prepupae 12hr
 
 1285
white prepupae 24hr
 
 1741
pupae 2d postWPP
 
 1007
pupae 3d postWPP
 
 622
pupae 4d postWPP
 
 758
adult male 01day
 
 740
adult male 05day
 
 932
adult male 30day
 
 959
adult female 01day
 
 2183
adult female 05day
 
 2618
adult female 30day
 
 2935
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Very low expression
Developmental Stage   Expression Level
embryo 00-02hr
 (4278)
embryo 02-04hr
 (5032)
embryo 04-06hr
 (4048)
embryo 06-08hr
 (4888)
embryo 08-10hr
 (3630)
embryo 10-12hr
 (1866)
embryo 12-14hr
 (2116)
embryo 14-16hr
 (2729)
embryo 16-18hr
 (1986)
embryo 18-20hr
 (1788)
embryo 20-22hr
 (1709)
embryo 22-24hr
 (1471)
larva L1
 (1198)
larva L2
 (822)
larva L3 12hr old
 (907)
larva L3 puffstage 1-2
 (519)
larva L3 puffstage 3-6
 (1482)
larva L3 puffstage 7-9
 (1298)
white prepupae new
 (1366)
white prepupae 12hr
 (1285)
white prepupae 24hr
 (1741)
pupae 2d postWPP
 (1007)
pupae 3d postWPP
 (622)
pupae 4d postWPP
 (758)
adult male 01day
 (740)
adult male 05day
 (932)
adult male 30day
 (959)
adult female 01day
 (2183)
adult female 05day
 (2618)
adult female 30day
 (2935)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
log, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 (4278)
embryo 02-04hr
 (5032)
embryo 04-06hr
 (4048)
embryo 06-08hr
 (4888)
embryo 08-10hr
 (3630)
embryo 10-12hr
 1866
embryo 12-14hr
 2116
embryo 14-16hr
 (2729)
embryo 16-18hr
 1986
embryo 18-20hr
 1788
embryo 20-22hr
 1709
embryo 22-24hr
 1471
larva L1
 
 1198
larva L2
 
 822
larva L3 12hr old
 
 907
larva L3 puffstage 1-2
 
 519
larva L3 puffstage 3-6
 1482
larva L3 puffstage 7-9
 
 1298
white prepupae new
 
 1366
white prepupae 12hr
 
 1285
white prepupae 24hr
 1741
pupae 2d postWPP
 
 1007
pupae 3d postWPP
 
 622
pupae 4d postWPP
 
 758
adult male 01day
 
 740
adult male 05day
 
 932
adult male 30day
 
 959
adult female 01day
 2183
adult female 05day
 (2618)
adult female 30day
 (2935)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 4278
embryo 02-04hr
 
 5032
embryo 04-06hr
 
 4048
embryo 06-08hr
 
 4888
embryo 08-10hr
 
 3630
embryo 10-12hr
 
 1866
embryo 12-14hr
 
 2116
embryo 14-16hr
 
 2729
embryo 16-18hr
 
 1986
embryo 18-20hr
 
 1788
embryo 20-22hr
 
 1709
embryo 22-24hr
 
 1471
larva L1
 
 1198
larva L2
 
 822
larva L3 12hr old
 
 907
larva L3 puffstage 1-2
 
 519
larva L3 puffstage 3-6
 
 1482
larva L3 puffstage 7-9
 
 1298
white prepupae new
 
 1366
white prepupae 12hr
 
 1285
white prepupae 24hr
 
 1741
pupae 2d postWPP
 
 1007
pupae 3d postWPP
 
 622
pupae 4d postWPP
 
 758
adult male 01day
 
 740
adult male 05day
 
 932
adult male 30day
 
 959
adult female 01day
 
 2183
adult female 05day
 
 2618
adult female 30day
 
 2935
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 4278
embryo 02-04hr
 
 5032
embryo 04-06hr
 
 4048
embryo 06-08hr
 
 4888
embryo 08-10hr
 
 3630
embryo 10-12hr
 
 1866
embryo 12-14hr
 
 2116
embryo 14-16hr
 
 2729
embryo 16-18hr
 
 1986
embryo 18-20hr
 
 1788
embryo 20-22hr
 
 1709
embryo 22-24hr
 
 1471
larva L1
 
 1198
larva L2
 
 822
larva L3 12hr old
 
 907
larva L3 puffstage 1-2
 
 519
larva L3 puffstage 3-6
 
 1482
larva L3 puffstage 7-9
 
 1298
white prepupae new
 
 1366
white prepupae 12hr
 
 1285
white prepupae 24hr
 
 1741
pupae 2d postWPP
 
 1007
pupae 3d postWPP
 
 622
pupae 4d postWPP
 
 758
adult male 01day
 
 740
adult male 05day
 
 932
adult male 30day
 
 959
adult female 01day
 
 2183
adult female 05day
 
 2618
adult female 30day
 
 2935
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
Heatmap
Developmental Stage   Expression Level
embryo 00-02hr
 
 
embryo 02-04hr
 
 
embryo 04-06hr
 
 
embryo 06-08hr
 
 
embryo 08-10hr
 
 
embryo 10-12hr
 
 
embryo 12-14hr
 
 
embryo 14-16hr
 
 
embryo 16-18hr
 
 
embryo 18-20hr
 
 
embryo 20-22hr
 
 
embryo 22-24hr
 
 
larva L1
 
 
larva L2
 
 
larva L3 12hr old
 
 
larva L3 puffstage 1-2
 
 
larva L3 puffstage 3-6
 
 
larva L3 puffstage 7-9
 
 
white prepupae new
 
 
white prepupae 12hr
 
 
white prepupae 24hr
 
 
pupae 2d postWPP
 
 
pupae 3d postWPP
 
 
pupae 4d postWPP
 
 
adult male 01day
 
 
adult male 05day
 
 
adult male 30day
 
 
adult female 01day
 
 
adult female 05day
 
 
adult female 30day
 
 

FlyAtlas Anatomical Expression Data for FBgn0004656


   Styles
Linear
Logarithmic
Heatmap
Back-to-back
   Scales
max expr for FBgn0004656
Moderate expression bin max
High level expression bin max
Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, larval trachea, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, adult spermathecae, adult male accessory gland, larval/adult carcass.
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Guide to FlyAtlas expression level colors
 
No expression (0 - 9.999)
 
Low expression (10 - 99.999)
 
Moderate expression (100 - 499.999)
 
High level expression (500 - 999.999)
 
Very high expression (1000 - 25000)

Heatmap
Tissue   Expression Level
Larval Central Nervous System no informative data
Larval Midgut no informative data
Larval Hindgut no informative data
Larval Malpighian Tubules no informative data
Larval Fat Body no informative data
Larval Salivary Gland no informative data
Larval Trachea no informative data
Larval Carcass no informative data
Adult Head no informative data
Adult Eye no informative data
Adult Brain no informative data
Adult Thoracic-Abdominal Ganglion no informative data
Adult Crop no informative data
Adult Midgut no informative data
Adult Hindgut no informative data
Adult Malpighian Tubules no informative data
Adult Fat Body no informative data
Adult Salivary Gland no informative data
Adult Heart no informative data
Adult VirginFemale Spermatheca no informative data
Adult InseminatedFemale Spermatheca no informative data
Adult Ovary no informative data
Adult Testis no informative data
Adult Male Accessory Gland no informative data
Adult Carcass no informative data

modENCODE Temporal Expression Data (Graveley et al., 2011)
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
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A cluster of genes with similar mRNA expression dynamics across development.
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Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyExpress - Embryonic expression images (BDGP data)
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hide Summary of Allele Phenotypes
Lethality
Allele
Sterility
Allele
Phenotype manifest in
Allele
hide Classical Alleles ( 50 )
For All Classical Alleles Show

Allele of fs(1)hClassMutagenStocksKnown lesion
fs(1)h182 Yes
fs(1)h12 Yes
fs(1)h42 Yes
fs(1)hG00932 --
fs(1)hG04952 --
fs(1)hrncantimorphic allele - genetic evidence2 Yes
fs(1)hCB-0428-3
1 --
fs(1)hd037031 --
fs(1)hd042801 --
fs(1)hEP4391 --
fs(1)hEY039381 --
fs(1)hEY106251 --
fs(1)hf00220
1 --
fs(1)hGS1147
1 Yes
fs(1)hGS5099
1 Yes
fs(1)hKG060111 --
fs(1)hNP0717
1 --
fs(1)hNP1020
1 --
fs(1)hNP1101
1 --
fs(1)hNP2065
1 --
fs(1)hNP6116
1 --
fs(1)hNP7115
1 --
fs(1)h1033B0 Yes
fs(1)h100 --
fs(1)h110 --
fs(1)h120 --
fs(1)h130 --
fs(1)h140 --
fs(1)h150 --
fs(1)h160 --
fs(1)h170 Yes
fs(1)h20 --
fs(1)h30 --
fs(1)h5-HA-2187
0 --
fs(1)h50 --
fs(1)h60 --
fs(1)h70 --
fs(1)h80 Yes
fs(1)h90 --
fs(1)hc068570 --
fs(1)hCPTI0013830 Yes
fs(1)hcx20.8
0 Yes
fs(1)hCXE10 Yes
fs(1)hEP10330 --
fs(1)hGG01199
0 --
fs(1)hGG01481
0 --
fs(1)hh3
0 --
fs(1)hNP4077
0 --
fs(1)hPA0 Yes
fs(1)hPE0 Yes
hide Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show

Allele of fs(1)hClassMutagenStocksKnown lesion
fs(1)hGD44522 Yes
fs(1)hGL000061 Yes
fs(1)hKK1015851 Yes
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Disrupted in
Duplicated in
Not disrupted in
Not duplicated in
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Transgenic Constructs
Type of construct
Name
Expression data
Insertions
Type of insertions
Name
Expression data
insertion of enhancer trap
hide Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
hide Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term
References
Cellular Component ( 0 terms)
hide Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term
References
non-traceable author statement
non-traceable author statement
Biological Process
CV term
References
Cellular Component ( 0 terms)
hide Sequence Ontology: Class of Gene
hide Interactions & Pathways
hide Summary of Physical Interactions
Protein-protein
Interacting group
Assay
References
hide Summary of Genetic Interactions
Interacts with
Please look at the allele data for full details of the genetic interactions
fs(1)h allele
Gene
References
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Linkouts
BioGRID - A database of protein and genetic interactions
DPiM - DPiM, Drosophila Protein interaction Map
DroID - A comprehensive database of gene and protein interactions.
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
hide Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs
Linkouts
InParanoid A subset of ortholog calls from InParanoid.
OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs.
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hide Stocks Listed in FlyBase ( 32 )
Bloomington
Harvard
Kyoto
VDRC
hide Genomic Clones ( 1 )
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
hide cDNA Clones ( 110 )
Please Note
This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
hide RNAi & Array Information
Linkouts
DRSC - Results from RNAi screens.
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
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hide Etymology
Named "rancor" after a (mythological) animal from (fictitious) Tatooine with a similar phenotype.
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hide Relationship to Other Genes
Source for database identity of
Source for identity of: fs(1)h CG2252
Source for database merge of
Source for merge of: fs(1)h anon-EST:fe1G2
Source for merge of: fs(1)h l(1)G0093 l(1)G0495
Source for merge of: fs(1)h rnc
Additional comments
Source for merge of fs(1)h anon-EST:fe1G2 was sequence comparison (date:030707).
hide Other Comments
When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of S phase cells, and/or aneuploidy, an increase in the proportion of G2/M phase cells, a decrease in mitotic index, a decrease in cytokinetic index and a decrease in the ratio of cells in prometaphase and metaphase versus the total number of mitotic cells are seen.
"7D5--6" was stated as revision.
Used in an investigation to address the relationship between retrotransposons and retroviruses and the coadaptation of these retroelements to their host genomes. Results indicate retrotransposons are heterogeneous in contrast to retroviruses, suggesting different modes of evolution by slippage-like mechanisms.
A protein sequence motif called the bromodomain has been found in fs(1)h and brm.
Fertility of fs(1)h homozygotes and fs(1)h/Df(1)C128 temperature-sensitive with the former becoming completely sterile at 29oC and the latter at 25oC; temperature-sensitive periods for fs(1)h/Df(1)C128 females during pregastrulation embryogenesis and perhaps late oogenesis. Eggs laid at restrictive temperatures exhibited normal preblastoderm development, although about half the nuclei are haploid; nuclear behavior during blastoderm formation disrupted and development arrested in blastoderm or early gastrulation. Larvae and adults surviving semi-permissive temperatures display homeotic anomalies; dead embryos and newly hatched larvae frequently have missing thoracic and anterior abdominal segments; surviving adults exhibit a sex ratio skewed in favor of males and frequently show missing halteres and less frequently third legs; effects are more severe in progeny of fs(1)h/Df(1)C128 than homozygous fs(1)h females, in daughters than sons and at 25oC than 23oC; small areas of homeotic transformations of anterior metathoracic to anterior mesothoracic structures also seen. The maternal effect of fs(1)h interacts synergistically with Ubx130, Df(3R)red1 and trx, but not Ubxbx-3 or Ubx. Most alleles are nonconditional lethals; fine structure mapping places two nonconditional alleles tested distal to the three tested conditional alleles.
Ubx, Kr and eve expression are altered in fs(1)h mutant embryos. Defects in the segmental organisation in fs(1)h-deficient progeny are mediated primarily, but not exclusively, through a restriction in the Kr expression domain.
Immunocytochemical staining demonstrates that fs(1)h is involved in establishment of a correct expression pattern for Kr, eve, en and Ubx.
Interactions with a mutation of the fs(1)h homeotic gene were used to confirm that ash1 and ash2 are members of a functionally related group of genes whose alleles have similar transformation properties to mutations of trx.
The temperature sensitive period for lethality is the pupal stage.
hide External Crossreferences & Linkouts
Sequence Crossreferences
RefSeq (Transcripts)
RefSeq (Proteins)
Entrez Gene - A searchable database of RefSeq genes.
Other Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
Bromodomain (IPR001487)
Linkouts
BioGRID - A database of protein and genetic interactions
DPiM - DPiM, Drosophila Protein interaction Map
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results from RNAi screens.
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
InParanoid A subset of ortholog calls from InParanoid.
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
modMine - Data generated by the modENCODE project.
OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs.
hide Synonyms & Secondary IDs ( 23 )
Reported As
Symbol Synonym
anon-EST:fe1G2
 
anon-EST:Liang-1.81
 
fs(1)26/26A
 
fs(1)R10.4
 
Name Synonym
anon-fast-evolving-1G2
 
female sterile (1) homeotic
female sterile (1) homoeotic
 
Secondary FlyBase IDs
  • FBgn0000809
  • FBgn0001447
  • FBgn0025246
  • FBgn0025884
  • FBgn0040137
  • FBgn0040199
hide References ( 81 )
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hide Recent research papers ( 1 )
Carreira et al., 2011, BMC Dev. Biol. 11: 32
Genetic basis of wing morphogenesis in Drosophila: sexual dimorphism and non-allometric effects of shape variation. [FBrf0214273]
hide Recent reviews (0)
All reviews listed in FlyBase were published before 2010