FB2021_05, released October 15, 2021

Gene: Dmel\fs(1)h

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General Information
Symbol
Dmel\fs(1)h
Species
D. melanogaster
Name
female sterile (1) homeotic
Annotation Symbol
CG2252
Feature Type
protein_coding_gene
FlyBase ID
FBgn0004656
Gene Model Status
Current
Stock Availability
39 publicly available
Gene Summary
female sterile (1) homeotic (fs(1)h) encodes a Bromodomain and Extra-Terminal domain (BET) family of protein, characterized by the presence of two tandem bromodomains and an extra-terminal (ET) domain. BET proteins can bind acetylated lysine residues in histones and regulate transcription. The proteins encoded by fs(1)h and human BRD2 possess protein kinase activity. [Date last reviewed: 2021-01-21] (FlyBase Gene Snapshot)
All Summaries
Also Known As

fsh, Fs(1)h-L, fs(1)M16, fs(1)1456, l(1)7Da

Key Links
Genomic Location
Cytogenetic map
7D3-7D5
Sequence location
Recombination map
1-22
RefSeq locus
NC_004354 REGION:8037808..8061436
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (8 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables chromatin binding
inferred from direct assay
(Gaub et al., 2020)
enables P-TEFb complex binding
inferred from direct assay
(Bisgrove et al., 2007)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables chromatin binding
inferred from sequence or structural similarity with UniProtKB:P25440
(FlyBase Curators, 2008--)
enables lysine-acetylated histone binding
inferred from sequence or structural similarity with UniProtKB:P25440
(FlyBase Curators, 2008--)
Biological Process (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
involved_in dendrite morphogenesis
inferred from mutant phenotype
(Bagley et al., 2014)
involved_in negative regulation of transcription, DNA-templated
inferred from mutant phenotype
(Florence and Faller, 2008)
involved_in positive regulation of transcription elongation from RNA polymerase II promoter
inferred from mutant phenotype
(Gaub et al., 2020)
involved_in terminal region determination
inferred from mutant phenotype
(Florence and Faller, 2008)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from high throughput direct assay
(Lye et al., 2014)
inferred from direct assay
(Bagley et al., 2014, Bisgrove et al., 2007)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
female sterile (1) homeotic (fs(1)h) encodes a Bromodomain and Extra-Terminal domain (BET) family of protein, characterized by the presence of two tandem bromodomains and an extra-terminal (ET) domain. BET proteins can bind acetylated lysine residues in histones and regulate transcription. The proteins encoded by fs(1)h and human BRD2 possess protein kinase activity. [Date last reviewed: 2021-01-21]
Gene Group (FlyBase)
OTHER DNA BINDING DOMAIN TRANSCRIPTION FACTORS -
The Other DNA binding domain transcription factors group is a collection of DNA-binding transcription factors that do not fit into any of the other major domain-based transcription factor groups.
ATYPICAL PROTEIN KINASES -
Atypical kinases are protein kinases or putative protein kinases that do not share clear sequence similarity with conventional eukaryotic protein kinases, but they or their orthologs have been shown experimentally to have protein kinase activity. Atypical kinases are defined in FBrf0201870.
Protein Function (UniProtKB)
Required maternally for proper expression of other homeotic genes involved in pattern formation, such as Ubx.
(UniProt, P13709)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
fs(1)h: female sterile (1) homeotic
Many mutant alleles at this locus are nonconditional lethals, but there are three temperature-sensitive hypomorphic alleles. fs(1)h1 is the weakest of these and many of the phenotypic studies have been carried out on it and on Df(1)C128, which is deficient for the locus. Temperature-sensitive genotypes display two periods of sensitivity to elevated temperature; one is during oogenesis and affects embryonic development and the other is during the pupal stage and affects adult survival. Adult survival of fs(1)h1 homozygotes and fs(1)h1/Df(1)C128 heterozygotes is normal at 20 and 25, but 10% and 0 respectively at 28.5. As mentioned above, the TSP for lethality is the pupal stage. fs(1)h15 shown to be lethal in germ-line clones (Perrimon, Engstrom, and Mahowald, 1984a, Dev. Biol. 105: 404-14). Fertility of fs(1)h homozygotes and fs(1)h/Df(1)C128 temperature sensitive with the former becoming completely sterile at 29 and the latter at 25; temperature-sensitive periods for fs(1)h/Df(1)C128 females during pregastrulation embryogenesis and perhaps late oogenesis. Eggs laid at restrictive temperatures exhibited normal preblastoderm development, although about half the nuclei are haploid; nuclear behavior during blastoderm formation disrupted and development arrested in blastoderm or early gastrulation. Larvae and adults surviving semi-permissive temperatures display homeotic anomalies; dead embryos, and newly hatched larvae frequently have missing thoracic and anterior abdominal segments; surviving adults exhibit a sex ratio skewed in favor of males and frequently show missing halteres and less frequently third legs; effects are more severe in progeny of fs(1)h/Df(1)C128 than homozygous fs(1)h females, in daughters than sons, and at 25 than 23; small areas of homeotic transformations of anterior metathoracic to anterior mesothoracic structures also seen. The maternal effect of fs(1)h interacts synergistically with Ubx130, Df(3R)red, and trx, but not bx3 or pbx.
Summary (Interactive Fly)

double-bromodomain protein - trithorax group gene that cooperates with Zeste in activation - regulates dendrite morphology

Gene Model and Products
Number of Transcripts
9
Number of Unique Polypeptides
5

Please see the JBrowse view of Dmel\fs(1)h for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.50

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.46

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 5.56

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
fs(1)h-RA
FBtr0071118
NM_167144
9146
1110
fs(1)h-RB
FBtr0071119
NM_078523
8942
2038
fs(1)h-RC
FBtr0071120
NM_206647
9034
1110
fs(1)h-RD
FBtr0071121
NM_206646
9071
1110
fs(1)h-RE
FBtr0071122
NM_206645
8773
1110
fs(1)h-RF
FBtr0301309
NM_001169228
5081
1110
fs(1)h-RG
FBtr0333307
NM_001272392
9949
2046
fs(1)h-RH
FBtr0333308
NM_001272393
9076
1105
fs(1)h-RI
FBtr0333309
NM_001272394
8716
1115
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
fs(1)h-PA
FBpp0071073
110.6
1110
9.83
NP_727228
AAN09226
fs(1)h-PB
FBpp0071074
205.3
2038
9.75
NP_511078
AAF46312
fs(1)h-PC
FBpp0089297
110.6
1110
9.83
NP_996370
AAS65277
fs(1)h-PD
FBpp0089298
110.6
1110
9.83
NP_996369
AAS65278
fs(1)h-PE
FBpp0089299
110.6
1110
9.83
NP_996368
AAS65279
fs(1)h-PF
FBpp0290524
110.6
1110
9.83
NP_001162699
ACZ95234
fs(1)h-PG
FBpp0305499
206.1
2046
9.83
NP_001259321
AGB95166
fs(1)h-PH
FBpp0305500
110.0
1105
9.86
NP_001259322
AGB95167
fs(1)h-PI
FBpp0305501
111.1
1115
9.88
NP_001259323
AGB95168
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1110 aa isoforms: fs(1)h-PA, fs(1)h-PC, fs(1)h-PD, fs(1)h-PE, fs(1)h-PF
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\fs(1)h using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
dendritic arborizing neuron

Comment: short isoform

(Bagley et al., 2014)
Additional Descriptive Data

The short isoform of fs(1)h protein is expressed in all dendritic arborizing neurons.

(Bagley et al., 2014)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in nucleus
inferred from high throughput direct assay
(Lye et al., 2014)
inferred from direct assay
(Bagley et al., 2014, Bisgrove et al., 2007)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\fs(1)h in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 58 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 15 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of fs(1)h
Transgenic constructs containing regulatory region of fs(1)h
Aberrations (Deficiencies and Duplications) ( 14 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
cell lethal | germline clone
lethal
lethal, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
lethal | heat sensitive
lethal | heat sensitive (with fs(1)h1)
lethal | heat sensitive (with fs(1)h1033B)
lethal | heat sensitive (with fs(1)hCXE1)
lethal | maternal effect | heat sensitive
lethal | recessive
lethal | rescuable maternal effect
lethal - all die before end of larval stage
lethal - all die before end of larval stage | male
lethal - all die before end of larval stage | recessive
lethal - all die before end of pupal stage | heat sensitive
lethal - all die during embryonic stage
lethal - all die during embryonic stage | maternal effect | heat sensitive (with fs(1)h1)
lethal - all die during embryonic stage | maternal effect | heat sensitive (with fs(1)hPA)
lethal - all die during embryonic stage | maternal effect | heat sensitive (with fs(1)hrnc)
lethal - all die during embryonic stage | maternal effect | partially | heat sensitive (with fs(1)h1)
lethal - all die during embryonic stage | maternal effect | partially | heat sensitive (with fs(1)h4)
lethal - all die during embryonic stage | recessive
lethal - all die during embryonic stage | recessive | rescuable maternal effect
lethal - all die during pupal stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female sterile, with Scer\GAL4nos.PG, Scer\GAL4VP16.nos.UTR, Scer\GAL4VP16.otu
female sterile | heat sensitive
female sterile | heat sensitive (with Df(1)C128)
female sterile | heat sensitive (with fs(1)h1)
female sterile | heat sensitive (with fs(1)h4)
female sterile | heat sensitive (with fs(1)hPA)
female sterile | heat sensitive (with fs(1)hrnc)
female sterile | maternal effect | recessive | heat sensitive
female sterile | recessive
fertile
Other Phenotypes
Allele
abnormal neuroanatomy | first instar larval stage | somatic clone
abnormal neuroanatomy | somatic clone | third instar larval stage
abnormal neuroanatomy | third instar larval stage, with Df(1)C128, Scer\GAL419-12
abnormal neuroanatomy | third instar larval stage, with Scer\GAL419-12
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4109(2)80
abnormal neurophysiology | third instar larval stage, with Scer\GAL419-12
abnormal touch perception | third instar larval stage, with Scer\GAL419-12
short lived | heat sensitive, with Scer\GAL4tin.CΔ4
some die during embryonic stage
some die during embryonic stage | maternal effect | heat sensitive (with fs(1)h1)
some die during embryonic stage | maternal effect | heat sensitive (with fs(1)hPA)
some die during embryonic stage | maternal effect | heat sensitive (with fs(1)hrnc)
some die during embryonic stage | partially | heat sensitive (with fs(1)h1)
some die during embryonic stage | partially | heat sensitive (with fs(1)h4)
some die during embryonic stage | recessive
some die during embryonic stage | rescuable maternal effect
some die during larval stage
some die during larval stage | male
some die during larval stage | recessive
some die during pupal stage | heat sensitive
Phenotype manifest in
Allele
abdominal segment 2 | maternal effect | heat sensitive (with fs(1)h1)
abdominal segment 2 | maternal effect | heat sensitive (with fs(1)h4)
abdominal segment 2 | maternal effect | heat sensitive (with fs(1)hPA)
abdominal segment 2 | maternal effect | heat sensitive (with fs(1)hrnc)
cephalopharyngeal skeleton
cephalopharyngeal skeleton | maternal effect | heat sensitive (with fs(1)h1)
cephalopharyngeal skeleton | maternal effect | heat sensitive (with fs(1)hPA)
dendrite | first instar larval stage | somatic clone
dendrite | somatic clone | third instar larval stage
dendrite | third instar larval stage, with Df(1)C128, Scer\GAL419-12
dendrite | third instar larval stage, with Scer\GAL419-12
dendrite | third instar larval stage, with Scer\GAL4109(2)80
egg
embryonic/first instar larval cuticle
embryonic/first instar larval cuticle | maternal effect | heat sensitive (with fs(1)h1)
embryonic/first instar larval cuticle | maternal effect | heat sensitive (with fs(1)h4)
embryonic head
filzkorper | maternal effect | heat sensitive (with fs(1)h1)
filzkorper | maternal effect | heat sensitive (with fs(1)hPA)
filzkorper | maternal effect | heat sensitive (with fs(1)hrnc)
hypostomal sclerite
larval head | maternal effect | heat sensitive (with fs(1)h1)
larval head | maternal effect | heat sensitive (with fs(1)hrnc)
larval multidendritic class III neuron | first instar larval stage | somatic clone
larval multidendritic class III neuron | somatic clone | third instar larval stage
larval multidendritic class III neuron | third instar larval stage, with Df(1)C128, Scer\GAL419-12
larval multidendritic class III neuron | third instar larval stage, with Scer\GAL419-12
larval multidendritic class III neuron | third instar larval stage, with Scer\GAL4109(2)80
larval multidendritic class II neuron | somatic clone | third instar larval stage
larval multidendritic class I neuron | somatic clone | third instar larval stage
larval multidendritic class IV neuron | somatic clone | third instar larval stage
larval multidendritic class IV neuron | third instar larval stage, with Scer\GAL4109(2)80
metathoracic segment
metathoracic segment | maternal effect
mouth hook
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (16)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\BRD2
9 of 15
Yes
Yes
 
2  
Hsap\BRD4
9 of 15
Yes
Yes
Hsap\BRDT
9 of 15
Yes
Yes
Hsap\BRD3
8 of 15
No
Yes
Hsap\BAZ2B
2 of 15
No
No
Hsap\BAZ1A
1 of 15
No
No
Hsap\BAZ1B
1 of 15
No
No
Hsap\BAZ2A
1 of 15
No
No
Hsap\BPTF
1 of 15
No
No
Hsap\BRD8
1 of 15
No
No
Hsap\CCDC127
1 of 15
No
Yes
Hsap\CREBBP
1 of 15
No
No
Hsap\EP300
1 of 15
No
No
Hsap\KAT2A
1 of 15
No
No
1  
Hsap\KAT2B
1 of 15
No
No
1  
Hsap\PBRM1
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (16)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Brd2
9 of 15
Yes
Yes
Mmus\Brd4
9 of 15
Yes
Yes
Mmus\Brdt
9 of 15
Yes
Yes
Mmus\Brd3
7 of 15
No
Yes
Mmus\4933408B17Rik
1 of 15
No
No
Mmus\Baz1b
1 of 15
No
No
Mmus\Baz2a
1 of 15
No
No
Mmus\Baz2b
1 of 15
No
No
Mmus\Bptf
1 of 15
No
No
Mmus\Brd8
1 of 15
No
No
Mmus\Cecr2
1 of 15
No
No
Mmus\Crebbp
1 of 15
No
No
Mmus\Ep300
1 of 15
No
No
Mmus\Kat2a
1 of 15
No
No
Mmus\Kat2b
1 of 15
No
No
Mmus\Pbrm1
1 of 15
No
No
Rattus norvegicus (Norway rat) (13)
Rnor\Brd4
8 of 13
Yes
Yes
Rnor\Brd2
5 of 13
No
No
Rnor\Brd3
3 of 13
No
No
Rnor\Brdt
3 of 13
No
No
Rnor\LOC100909544
3 of 13
No
Yes
Rnor\Baz1a
1 of 13
No
No
Rnor\Baz1b
1 of 13
No
No
Rnor\Brd8
1 of 13
No
No
Rnor\Cecr2
1 of 13
No
No
Rnor\Crebbp
1 of 13
No
No
Rnor\Kat2a
1 of 13
No
No
Rnor\LOC108348112
1 of 13
No
Yes
Rnor\Pbrm1
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (15)
Xtro\brd2
5 of 12
Yes
Yes
Xtro\brd3
5 of 12
Yes
Yes
Xtro\brd4
4 of 12
No
Yes
Xtro\brdt
4 of 12
No
Yes
Xtro\baz1a
1 of 12
No
No
Xtro\baz1b
1 of 12
No
No
Xtro\baz2a
1 of 12
No
No
Xtro\baz2b
1 of 12
No
No
Xtro\bptf
1 of 12
No
No
Xtro\brd8
1 of 12
No
No
Xtro\cecr2
1 of 12
No
No
Xtro\crebbp
1 of 12
No
No
Xtro\kat2a
1 of 12
No
No
Xtro\kat2b
1 of 12
No
No
Xtro\pbrm1
1 of 12
No
No
Danio rerio (Zebrafish) (22)
Drer\brd2a
9 of 15
Yes
Yes
Drer\brdt
9 of 15
Yes
Yes
Drer\brd3a
8 of 15
No
Yes
Drer\brd4
7 of 15
No
Yes
Drer\brd3b
5 of 15
No
Yes
Drer\brd2b
3 of 15
No
Yes
Drer\baz1a
1 of 15
No
No
Drer\baz2ba
1 of 15
No
No
Drer\bptf
1 of 15
No
No
Drer\brd8
1 of 15
No
No
Drer\cecr2
1 of 15
No
No
Drer\crebbpa
1 of 15
No
No
Drer\crebbpb
1 of 15
No
No
Drer\crebbp
1 of 15
No
No
Drer\ep300a
1 of 15
No
No
Drer\ep300b
1 of 15
No
No
Drer\kat2a
1 of 15
No
No
Drer\kat2b
1 of 15
No
No
Drer\LOC100536981
1 of 15
No
No
Drer\pbrm1
1 of 15
No
No
Drer\pbrm1l
1 of 15
No
No
Drer\si:ch211-59d17.3
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (16)
Cele\bet-1
9 of 15
Yes
Yes
Cele\bet-2
5 of 15
No
Yes
Cele\F13C5.2
4 of 15
No
No
Cele\athp-2
1 of 15
No
No
Cele\baz-2
1 of 15
No
No
Cele\C29F9.5
1 of 15
No
No
Cele\C49F5.5
1 of 15
No
No
Cele\cbp-1
1 of 15
No
No
Cele\CE7X_3.2
1 of 15
No
Yes
Cele\F22F1.3
1 of 15
No
Yes
Cele\F53H1.4
1 of 15
No
No
Cele\F59F5.7
1 of 15
No
Yes
Cele\pbrm-1
1 of 15
No
No
Cele\pcaf-1
1 of 15
No
No
Cele\sepa-1
1 of 15
No
Yes
Cele\ZK1010.10
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (10)
Atha\GTE3
3 of 9
Yes
Yes
Atha\AT1G17790
2 of 9
No
Yes
Atha\BET9
2 of 9
No
Yes
Atha\GTE2
2 of 9
No
Yes
Atha\GTE4
2 of 9
No
Yes
Atha\GTE7
2 of 9
No
Yes
Atha\IMB1
2 of 9
No
Yes
Atha\BET10
1 of 9
No
No
Atha\GTE8
1 of 9
No
Yes
Atha\NPX1
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (9)
Scer\BDF1
10 of 15
Yes
Yes
Scer\BDF2
10 of 15
Yes
Yes
Scer\SPT7
2 of 15
No
Yes
Scer\GCN5
1 of 15
No
No
1  
Scer\ITC1
1 of 15
No
No
Scer\RSC1
1 of 15
No
No
Scer\RSC2
1 of 15
No
No
Scer\RSC4
1 of 15
No
No
Scer\YPL216W
1 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (3)
Spom\bdf1
8 of 12
Yes
Yes
Spom\SPAC631.02
7 of 12
No
Yes
Spom\spt7
1 of 12
No
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091902SR )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00005972
Drosophila simulans
Dsim\GD16134
Drosophila sechellia
Dsec\GM11218
Drosophila erecta
Dere\GG17589
Drosophila yakuba
Dyak\GE17489
Drosophila pseudoobscura pseudoobscura
Dpse\GA26201
Drosophila persimilis
Dper\GL14811
Drosophila willistoni
Dwil\GK15212
Drosophila mojavensis
Dmoj\GI15407
Drosophila grimshawi
Dgri\GH17935
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502GO )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17022148
Glossina morsitans
Tsetse fly
Gmor\GMOY003902
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_03730
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL002090
Anopheles darlingi
American malaria mosquito
Adar\ADAC006464
Anopheles gambiae
Malaria mosquito
Agam\AGAP002807
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ004311
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W03PC )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Danaus plexippus
Monarch butterfly
Dple\DPOGS204391-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL007823
Apis florea
Little honeybee
Aflo\2147541123
Apis mellifera
Western honey bee
Amel\GB49193
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25781
Bombus terrestris
Buff-tailed bumblebee
Bter\15212755
Bombus terrestris
Buff-tailed bumblebee
Bter\15202906
Linepithema humile
Argentine ant
Lhum\LH13398
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002fff
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG009808
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08090
Tribolium castaneum
Red flour beetle
Tcas\TC030673
Pediculus humanus
Human body louse
Phum\PHUM211000
Rhodnius prolixus
Kissing bug
Rpro\RPRC003784
Cimex lectularius
Bed bug
Clec\CLEC002802
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005684
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_14137
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X06G6 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR003490
Ixodes scapularis
Black-legged tick
Isca\ISCW010077
Stegodyphus mimosarum
African social velvet spider
Smim\KFM59840.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM66110.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur07g05350
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_302185
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G01QC )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Brd
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_003459gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_016632gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Brd2
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000023500
Gallus gallus
Domestic chicken
Ggal\BRDT
Gallus gallus
Domestic chicken
Ggal\BRD3
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000013295
Gallus gallus
Domestic chicken
Ggal\BRD2
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (11)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
tbrd-1
4 of 10
tbrd-3
4 of 10
tbrd-2
3 of 10
Acf
1 of 10
Brd8
1 of 10
dikar
1 of 10
Gcn5
1 of 10
Lpt
1 of 10
nej
1 of 10
polybromo
1 of 10
tou
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 1 )
Human Ortholog
Disease
Evidence
References
BRDT; bromodomain testis associated
model of  spermatogenic failure 21
IEA
(FlyBase, 2019-)
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
BRD2; bromodomain containing 2
9 of 15
601540
       
      BRD4; bromodomain containing 4
      9 of 15
      608749
          BRDT; bromodomain testis associated
          9 of 15
          602144
          BRD3; bromodomain containing 3
          8 of 15
          601541
              Functional Complementation Data
              Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
              Dmel gene
              Ortholog showing functional complementation
              Supporting References
              fs(1)h
              Hsap\BRD2
              (Bagley et al., 2014)
              Interactions
              Summary of Physical Interactions
              esyN Network Diagram
              Show neighbor-neighbor interactions:
              Select Layout:
              Legend:
              Protein
              RNA
              Selected Interactor(s)
              Interactions Browser
              View in Interactions Browser
              Please see the Physical Interaction reports below for full details
              protein-protein
              Physical Interaction
              Assay
              References
              fs(1)h - BEAF-32
              anti bait coimmunoprecipitation, western blot
              (Kellner et al., 2013)
              fs(1)h - Cp190
              anti bait coimmunoprecipitation, western blot, pull down
              (Kellner et al., 2013)
              fs(1)h - His3
              pull down, anti tag western blot
              (Kockmann et al., 2013)
              fs(1)h - His4
              pull down, anti tag western blot
              (Kockmann et al., 2013)
              fs(1)h - PIP4K
              anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
              (Rhee et al., 2014)
              fs(1)h - Pc
              pull down, peptide massfingerprinting, tandem affinity purification, Identification by mass spectrometry, western blot
              (Kang et al., 2015, Strübbe et al., 2011)
              fs(1)h - Psc
              cross-linking study, tandem affinity purification, Identification by mass spectrometry, anti tag coimmunoprecipitation, western blot, molecular weight estimation by staining
              (Kang et al., 2017)
              fs(1)h - Su(z)2
              cross-linking study, tandem affinity purification, Identification by mass spectrometry
              (Kang et al., 2017)
              fs(1)h - Trl
              anti bait coimmunoprecipitation, western blot, pull down
              (Kellner et al., 2013)
              fs(1)h - ash1
              ion exchange chromatography, anti tag coimmunoprecipitation, peptide massfingerprinting, anti tag western blot
              (Kockmann et al., 2013)
              fs(1)h - cnc
              anti tag coimmunoprecipitation, western blot
              (Chatterjee et al., 2016)
              fs(1)h - east
              anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
              (Rhee et al., 2014)
              fs(1)h - mod(mdg4)
              anti bait coimmunoprecipitation, western blot, pull down
              (Kellner et al., 2013)
              fs(1)h - su(Hw)
              pull down, western blot, anti bait coimmunoprecipitation
              (Kellner et al., 2013)
              Summary of Genetic Interactions
              esyN Network Diagram
              esyN Network Key:
              Suppression
              Enhancement
              View in Interactions Browser
              Please look at the allele data for full details of the genetic interactions
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              fs(1)h
              enhanceable
              ash2
              (Shearn, 1989)
              fs(1)h
              suppressible
              Rac1
              (Bagley et al., 2014)
              fs(1)h
              enhanceable
              trx
              (Shearn, 1989)
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              ct
              suppressible
              fs(1)h
              (Bagley et al., 2014)
              Dfd
              enhanceable
              fs(1)h
              (Florence and McGinnis, 1998)
              Dref
              enhanceable
              fs(1)h
              (Ida et al., 2009)
              pbl
              suppressible
              fs(1)h
              (Gregory et al., 2007)
              pbl
              enhanceable
              fs(1)h
              (Gregory et al., 2007)
              External Data
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              MIST (genetic) - An integrated Molecular Interaction Database
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Pathways
              Signaling Pathways (FlyBase)
              Metabolic Pathways
              FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
              External Data
              Linkouts
              Genomic Location and Detailed Mapping Data
              Chromosome (arm)
              X
              Recombination map
              1-22
              Cytogenetic map
              7D3-7D5
              Sequence location
              FlyBase Computed Cytological Location
              Cytogenetic map
              Evidence for location
              7D3-7D5
              Limits computationally determined from genome sequence between P{EP}snEP1217 and P{EP}Ubc-E2HEP1303
              Experimentally Determined Cytological Location
              Cytogenetic map
              Notes
              References
              7D5-7D6
              (Schäfer, 2003.12.4)
              7D3-7D4
              (determined by in situ hybridisation)
              (Peter et al., 2002)
              12C-12C
              (determined by in situ hybridisation) 7D3--4 (determined by in situ hybridisation)
              (Schäfer et al., 1999.12.2)
              7D5-7D6
              (determined by in situ hybridisation)
              (Haynes et al., 1989)
              7D4-7D6
              (determined by in situ hybridisation)
              (Digan et al., 1986)
              There is a discrepancy between the in situ localisation (12C) and the molecular localisation based on the flanking sequence (7D5--7D6) for the "l(1)G0495" (fs(1)hG0495) line. The available data suggests that it is most likely that the molecular localisation (7D5--7D6) is correct and that the in situs were misinterpreted.
              (Schäfer, 2003.12.4)
              Experimentally Determined Recombination Data
              Location

              1-22

              (FlyBase, 2016)

              1-22.2

              (Comeron et al., 2012)

              1-

              (Mohler, 1977)

              1-21.65

              Left of (cM)
              (Mohler, 1977)
              (Monastirioti et al., 1996)
              Right of (cM)
              (Monastirioti et al., 1996)
              (Mohler, 1977)
              Notes
              Stocks and Reagents
              Stocks (39)
              Genomic Clones (23)
              cDNA Clones (106)
               

              Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

              cDNA clones, fully sequenced
              BDGP DGC clones
              Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               

              polyclonal

              (Mazina et al., 2018, Kellner et al., 2013)
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of

              Source for identity of: fs(1)h CG2252

              (Zhang, 1999.11)
              Source for database merge of

              Source for merge of: fs(1)h rnc

              (Florence et al., 2001)

              Source for merge of: fs(1)h l(1)G0093 l(1)G0495

              (Peter et al., 2002)

              Source for merge of: fs(1)h anon- EST:fe1G2

              (FlyBase, 1996-)
              Additional comments

              Source for merge of fs(1)h anon- EST:fe1G2 was sequence comparison ( date:030707 ).

              (FlyBase, 1996-)
              Other Comments

              fs(1)h is necessary for the induction of dendrite branching caused by ct.

              (Bagley et al., 2014)

              DNA-protein interactions:GEO_GSE30820 .

              (Sakoparnig et al., 2012)

              When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of S phase cells, and/or aneuploidy, an increase in the proportion of G2/M phase cells, a decrease in mitotic index, a decrease in cytokinetic index and a decrease in the ratio of cells in prometaphase and metaphase versus the total number of mitotic cells are seen.

              (Bettencourt-Dias et al., 2004)

              "7D5--6" was stated as revision.

              (Schäfer, 2003.12.4)

              Used in an investigation to address the relationship between retrotransposons and retroviruses and the coadaptation of these retroelements to their host genomes. Results indicate retrotransposons are heterogeneous in contrast to retroviruses, suggesting different modes of evolution by slippage-like mechanisms.

              (Terzian et al., 1997)

              A protein sequence motif called the bromodomain has been found in fs(1)h and brm.

              (Haynes et al., 1992)

              Fertility of fs(1)h homozygotes and fs(1)h/Df(1)C128 temperature-sensitive with the former becoming completely sterile at 29oC and the latter at 25oC; temperature-sensitive periods for fs(1)h/Df(1)C128 females during pregastrulation embryogenesis and perhaps late oogenesis. Eggs laid at restrictive temperatures exhibited normal preblastoderm development, although about half the nuclei are haploid; nuclear behavior during blastoderm formation disrupted and development arrested in blastoderm or early gastrulation. Larvae and adults surviving semi-permissive temperatures display homeotic anomalies; dead embryos and newly hatched larvae frequently have missing thoracic and anterior abdominal segments; surviving adults exhibit a sex ratio skewed in favor of males and frequently show missing halteres and less frequently third legs; effects are more severe in progeny of fs(1)h/Df(1)C128 than homozygous fs(1)h females, in daughters than sons and at 25oC than 23oC; small areas of homeotic transformations of anterior metathoracic to anterior mesothoracic structures also seen. The maternal effect of fs(1)h interacts synergistically with Ubx130, Df(3R)red1 and trx, but not Ubxbx-3 or Ubx. Most alleles are nonconditional lethals; fine structure mapping places two nonconditional alleles tested distal to the three tested conditional alleles.

              (Lindsley and Zimm, 1992)

              Ubx, Kr and eve expression are altered in fs(1)h mutant embryos. Defects in the segmental organisation in fs(1)h-deficient progeny are mediated primarily, but not exclusively, through a restriction in the Kr expression domain.

              (Huang and Dawid, 1990)

              Immunocytochemical staining demonstrates that fs(1)h is involved in establishment of a correct expression pattern for Kr, eve, en and Ubx.

              (Huang and Dawid, 1989)

              Interactions with a mutation of the fs(1)h homeotic gene were used to confirm that ash1 and ash2 are members of a functionally related group of genes whose alleles have similar transformation properties to mutations of trx.

              (Shearn, 1989)

              The temperature sensitive period for lethality is the pupal stage.

              (Perrimon et al., 1984)
              Origin and Etymology
              Discoverer
              Etymology

              Named "rancor" after a (mythological) animal from (fictitious) Tatooine with a similar phenotype.

              (Florence and McGinnis, 1998)
              Identification
              External Crossreferences and Linkouts ( 97 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              modMine - A data warehouse for the modENCODE project
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              FlyMine - An integrated database for Drosophila genomics
              Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
              MIST (genetic) - An integrated Molecular Interaction Database
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Synonyms and Secondary IDs (34)
              Reported As
              Symbol Synonym
              Brd4
              (Haberle et al., 2019)
              CG2252
              (Haelterman et al., 2014, Christis and Munro, 2012, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Ida et al., 2009, Keleman et al., 2009.8.5)
              FSH
              (Kockmann et al., 2013)
              Fs(1)h
              (Sakamaki et al., 2017, Chatterjee et al., 2016, Kellner et al., 2013, Strübbe et al., 2011)
              Fs(1)h-L
              (Mourad and Cuvier, 2018, Cubeñas-Potts et al., 2017, Mourad et al., 2017, Li et al., 2015)
              Fs(1)h/Brd4
              (Mazina et al., 2017)
              Fs(1)hL
              (Florence and Faller, 2008)
              Fs(1)hS
              (Florence and Faller, 2008)
              Fsh
              (Comoglio and Paro, 2014, Jennings, 2013, Sakoparnig et al., 2012)
              N72
              (Schalet, 1986)
              ORE-1
              (Maia et al., 2007)
              anon-EST:Liang-1.81
              anon-EST:fe1G2
              clone 1.81
              (Liang and Biggin, 1998)
              dBRD4
              (Gaub et al., 2020)
              fs(1)1456
              (Foe et al., 1993, Perrimon et al., 1986, Mohler and Carroll, 1984)
              fs(1)26/26A
              fs(1)M16
              (Perrimon et al., 1986, Mohler and Carroll, 1984, Mohler, 1977)
              fs(1)R10.4
              fs(1)h
              (Khan et al., 2021, Feuillette et al., 2020, Hung et al., 2020, Zhang et al., 2020, Luna-Peláez et al., 2019, Pherson et al., 2019, Gene Disruption Project members, 2018-, Tamirisa et al., 2018, Lou et al., 2017, Sharma et al., 2017, Transgenic RNAi Project members, 2017-, Clandinin and Owens, 2016-, Copf, 2015, Kang et al., 2015, model organism Encyclopedia of Regulatory Network (modERN) Project, 2015-, Ashwal-Fluss et al., 2014, Bagley et al., 2014, Haelterman et al., 2014, Lye et al., 2014, Sopko et al., 2014, Jennings, 2013, Kockmann et al., 2013, Yamamoto et al., 2013-, Follmer et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Carreira et al., 2011, Florence, 2010.5.7, Popodi et al., 2010-, Ayroles et al., 2009, Ida et al., 2009, Florence and Faller, 2008, Bisgrove et al., 2007, Chang et al., 2007, Gregory et al., 2007, Maia et al., 2007)
              fs[1]h
              (Graves et al., 2020)
              fsh
              (Jennings, 2013, Florence et al., 2001, Huang et al., 1999, Papoulas et al., 1998, Lin et al., 1997, Terzian et al., 1997, Denis and Green, 1996, Huang et al., 1996, Huang et al., 1995, Muchardt and Yaniv, 1993, Haynes et al., 1992, Huang and Dawid, 1990, Haynes et al., 1989)
              fst(1)h
              (Madueno et al., 1995)
              l(1)7Da
              (Zheng et al., 2003)
              l(1)G0093
              (Schäfer et al., 1999.12.2)
              l(1)G0495
              (Schäfer et al., 1999.12.2)
              rnc
              (Florence and McGinnis, 1998)
              Name Synonyms
              Female sterile 1 homeotic
              (Copf, 2015)
              anon-fast-evolving-1G2
              female sterile (1) homeotic
              (Graves et al., 2020, Comoglio and Paro, 2014, Jennings, 2013, Lavagnino et al., 2013, Pool et al., 2012, Florence and Faller, 2008, Chang et al., 2007)
              female sterile (1) homoeotic
              female sterile 1 homeotic
              (Bagley et al., 2014)
              female sterile homeotic
              (Bisgrove et al., 2007)
              rancor
              (Florence and McGinnis, 1998)
              Secondary FlyBase IDs
              • FBgn0000809
              • FBgn0001447
              • FBgn0025246
              • FBgn0025884
              • FBgn0040137
              • FBgn0040199
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              References (161)