fsh, Fs(1)h-L, fs(1)M16, fs(1)1456, l(1)G0093
Gene model reviewed during 5.50
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.46
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.56
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\fs(1)h using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\fs(1)h in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: fs(1)h CG2252
Source for merge of fs(1)h anon- EST:fe1G2 was sequence comparison ( date:030707 ).
DNA-protein interactions:GEO_GSE30820 .
When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of S phase cells, and/or aneuploidy, an increase in the proportion of G2/M phase cells, a decrease in mitotic index, a decrease in cytokinetic index and a decrease in the ratio of cells in prometaphase and metaphase versus the total number of mitotic cells are seen.
"7D5--6" was stated as revision.
Used in an investigation to address the relationship between retrotransposons and retroviruses and the coadaptation of these retroelements to their host genomes. Results indicate retrotransposons are heterogeneous in contrast to retroviruses, suggesting different modes of evolution by slippage-like mechanisms.
Fertility of fs(1)h homozygotes and fs(1)h/Df(1)C128 temperature-sensitive with the former becoming completely sterile at 29oC and the latter at 25oC; temperature-sensitive periods for fs(1)h/Df(1)C128 females during pregastrulation embryogenesis and perhaps late oogenesis. Eggs laid at restrictive temperatures exhibited normal preblastoderm development, although about half the nuclei are haploid; nuclear behavior during blastoderm formation disrupted and development arrested in blastoderm or early gastrulation. Larvae and adults surviving semi-permissive temperatures display homeotic anomalies; dead embryos and newly hatched larvae frequently have missing thoracic and anterior abdominal segments; surviving adults exhibit a sex ratio skewed in favor of males and frequently show missing halteres and less frequently third legs; effects are more severe in progeny of fs(1)h/Df(1)C128 than homozygous fs(1)h females, in daughters than sons and at 25oC than 23oC; small areas of homeotic transformations of anterior metathoracic to anterior mesothoracic structures also seen. The maternal effect of fs(1)h interacts synergistically with Ubx130, Df(3R)red1 and trx, but not Ubxbx-3 or Ubx. Most alleles are nonconditional lethals; fine structure mapping places two nonconditional alleles tested distal to the three tested conditional alleles.
Ubx, Kr and eve expression are altered in fs(1)h mutant embryos. Defects in the segmental organisation in fs(1)h-deficient progeny are mediated primarily, but not exclusively, through a restriction in the Kr expression domain.
Interactions with a mutation of the fs(1)h homeotic gene were used to confirm that ash1 and ash2 are members of a functionally related group of genes whose alleles have similar transformation properties to mutations of trx.
The temperature sensitive period for lethality is the pupal stage.
Named "rancor" after a (mythological) animal from (fictitious) Tatooine with a similar phenotype.