Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\l(2)41Ae using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\l(2)41Ae in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
l(2)41Ae is NOT a single locus, but rather a large region (referred to as the '41Ae region') that is defined by the breakpoints of Df(2R)34-2 and includes the genes uex, Haspin, CG17683, CG40127 and CG17665.
The "l(2)41Ae" locus fails to complement mutations in 7 genes ("l(2)NC37", "l(2)NC38", "l(2)NC133", "l(2)NC110", "l(2)NC70", "l(2)IR3" and "l(2)IR23"). The "l(2)41Ae" locus has previously been shown to have complex complementation behaviour (FBrf0028786). This information suggests that the "l(2)41Ae" "locus" may contain mutations in different genes.
The "l(2)41Ae" locus may be a deletion as it fails to complement seven different complementation groups isolated in this study.
Complementation map shaped like a figure eight and highly complex. Four heteroallelic combinations exhibit partial complementation: l(2)41Ae10/l(2)41Ae15 shows 17% survival, l(2)41Ae10/l(2)41Ae19 8% survival, l(2)41Ae9/l(2)41Ae28 10% survival and l(2)41Ae21/l(2)41Ae28 21% viability. The remaining combinations exhibit noncomplementation or complete complementation. In spite of the fact that among alleles l(2)41Ae35 to l(2)41Ae40, there is only one noncomplementing pair of alleles, l(2)41Ae35 and l(2)41Ae36, these mutants are designated alleles of l(2)41Ae on the basis of their inclusion in Df(2R)M41A4, Df(2R)M41A8, Df(2R)M41A10 and Df(2R)M41A50j and the extensive complementation characteristic of l(2)41Ae alleles.
l(2)41Ae locus exhibits high EMS mutability and the lethal alleles exhibit a complex interallelic complementation.
Heterozygotes not Minute