A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Gene Dmel\l(2)41Ae

General Information
SymbolDmel\l(2)41AeSpeciesD. melanogaster
Namelethal (2) 41AeAnnotation symbol
Feature typegeneFlyBase IDFBgn0004660
Gene Model StatusUnannotated Stock availability None publicly available
Also Known As41Ae, GroupIV
Genomic Location
Chromosome (arm)Recombination map2-55.1
Cytogenetic maph45-h46Sequence location
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Automatically generated summary

See sections below for more information
The gene lethal (2) 41Ae is referred to in FlyBase by the symbol Dmel\l(2)41Ae (FBgn0004660). It is a gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 37 alleles are reported. No phenotypic data is available. It has no annotated transcripts. Gene has not been localized to the genome sequence.

User Contributed Data
hide Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage
l(2)41Ae
Heterozygotes not Minute. Complementation map shaped like a figure eight and highly complex. Four heteroallelic combinations exhibit partial complementation: l(2)41Ae10/l(2)41Ae15 shows 17% survival, l(2)41Ae10/l(2)41Ae19 8% survival, l(2)41Ae9/l(2)41Ae28 10% survival, and l(2)41Ae21/l(2)41Ae28 21% viability. The remaining combinations exhibit noncomplementation or complete complementation. In spite of the fact that among alleles l(2)41Ae35 to l(2)41Ae40, there is only one noncomplementing pair of alleles, l(2)41Ae35 and l(2)41Ae36, these mutants are designated alleles of l(2)41Ae on the basis of their inclusion in Df(2R)M41A-4, Df(2R)M41A-8, Df(2R)M41A-10, and Df(2R)M41A-50j and the extensive complementation characteristic of l(2)41Ae alleles.
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Description
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FB2013_03
FB2013_02
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hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
h45-h46  
Left limit from non-inclusion within Tp(2;Y)Rsp31 (FBrf0030142) Right limit from inclusion within Df(2R)rl-5B (FBrf0028786)  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
h35-h35  
(determined by in situ hybridisation)  
(Dimitri, 1991)
Experimentally Determined Recombination Data
Location
2-55.1
 
2-
(Rollins et al., 1997, Rollins et al., 1998)
Left of (cM)
Right of (cM)
Notes
hide Gene Model & Products
Comments on Gene Model
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Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
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Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
hide Mapped Features
Type
Symbol & Location
Additional Notes
References
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Linkouts
Crossreferences
hide Expression Data
hideTranscript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
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Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term
Evidence
References
hide Expression Deduced from Reporters
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Associated Tools
Reference
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
hide FlyAtlas Anatomy Microarray
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Linkouts
hide Alleles & Phenotypes
hide Summary of Allele Phenotypes
Lethality
Allele
lethal (with l(2)41Ae16)
lethal (with l(2)41Ae17)
lethal | recessive
Phenotype manifest in
Allele
hide Classical Alleles ( 37 )
For All Classical Alleles Show

Allele of l(2)41AeClassMutagenStocksKnown lesion
l(2)41Ae100 Yes
l(2)41Ae110 Yes
l(2)41Ae120 Yes
l(2)41Ae130 Yes
l(2)41Ae140 Yes
l(2)41Ae150 Yes
l(2)41Ae160 Yes
l(2)41Ae170 Yes
l(2)41Ae180 Yes
l(2)41Ae190 Yes
l(2)41Ae200 Yes
l(2)41Ae220 Yes
l(2)41Ae240 Yes
l(2)41Ae260 Yes
l(2)41Ae270 Yes
l(2)41Ae290 Yes
l(2)41Ae300 Yes
l(2)41Ae310 Yes
l(2)41Ae320 Yes
l(2)41Ae330 Yes
l(2)41Ae34-4
0 --
l(2)41Ae340 Yes
l(2)41Ae35
0 --
l(2)41Ae36
0 --
l(2)41Ae37
0 --
l(2)41Ae38
0 --
l(2)41Ae3940 Yes
l(2)41Ae390 --
l(2)41Ae30 Yes
l(2)41Ae40
0 --
l(2)41Ae40 Yes
l(2)41Ae50 Yes
l(2)41Ae80 Yes
l(2)41Ae90 Yes
l(2)41AeIR140 --
l(2)41AeIR250 --
l(2)41AeIR260 --
hide Alleles Carried on Transgenic Constructs ( 0 )
For All Alleles Carried on Transgenic Constructs Show

Allele of l(2)41AeClassMutagenStocksKnown lesion
hide Aneuploid Aberrations
Disrupted in
(Hilliker and Holm, 1975, Hilliker, 1976, Ganetzky, 1977, Sharp et al., 1985, Eberl et al., 1993, Duffy et al., 1996, Koryakov and Zhimulev, 1996)
(Rollins et al., 1999, Hilliker and Holm, 1975, Sharp et al., 1985, Koryakov and Zhimulev, 1996, Dimitri et al., 1997)
(Rollins et al., 1999, Hilliker and Holm, 1975, Hilliker, 1976, Ganetzky, 1977, Eberl et al., 1993, Duffy et al., 1996, Koryakov and Zhimulev, 1996)
(Rollins et al., 1999)
(Rollins et al., 1999)
(Rollins et al., 1999)
(Hilliker, 1976, Ganetzky, 1977)
(Hilliker, 1976, Ganetzky, 1977)
(Hilliker, 1976, Ganetzky, 1977)
(Hilliker, 1976, Ganetzky, 1977)
(Hilliker, 1976, Ganetzky, 1977)
(Hilliker, 1976, Ganetzky, 1977)
Not disrupted in
(Hilliker and Holm, 1975)
(Hilliker, 1976, Ganetzky, 1977)
(Rollins et al., 1999)
(Rollins et al., 1999)
(Rollins et al., 1999)
(Rollins et al., 1999)
(Eberl et al., 1993)
(Eberl et al., 1993)
(Eberl et al., 1993)
(Hilliker, 1976, Ganetzky, 1977)
(Hilliker, 1976, Ganetzky, 1977)
(Hilliker, 1976)
(Rollins et al., 1999, Hilliker, 1976, Ganetzky, 1977)
(Hilliker, 1976, Ganetzky, 1977)
(Hilliker, 1976)
(Hilliker, 1976)
(Hilliker, 1976)
(Hilliker, 1976)
(Ganetzky, 1977)
(Ganetzky, 1977)
(Ganetzky, 1977)
(Rollins et al., 1999)
(Dimitri, 1991)
(Dimitri, 1991)
Duplicated in
(Brittnacher and Ganetzky, 1989)
(Brittnacher and Ganetzky, 1989)
(Brittnacher and Ganetzky, 1989)
(Brittnacher and Ganetzky, 1989)
(Brittnacher and Ganetzky, 1989)
Not duplicated in
(Brittnacher and Ganetzky, 1989)
(Brittnacher and Ganetzky, 1989)
(Brittnacher and Ganetzky, 1989)
(Brittnacher and Ganetzky, 1989)
(Brittnacher and Ganetzky, 1989)
(Brittnacher and Ganetzky, 1989)
(Brittnacher and Ganetzky, 1989)
(Brittnacher and Ganetzky, 1989)
(Brittnacher and Ganetzky, 1989)
(Brittnacher and Ganetzky, 1989)
(Brittnacher and Ganetzky, 1989)
(Brittnacher and Ganetzky, 1989)
(Brittnacher and Ganetzky, 1989)
(Brittnacher and Ganetzky, 1989)
(Brittnacher and Ganetzky, 1989)
(Brittnacher and Ganetzky, 1989)
(Brittnacher and Ganetzky, 1989)
(Brittnacher and Ganetzky, 1989)
(Brittnacher and Ganetzky, 1989)
(Brittnacher and Ganetzky, 1989)
(Brittnacher and Ganetzky, 1989)
(Brittnacher and Ganetzky, 1989)
(Brittnacher and Ganetzky, 1989)
(Brittnacher and Ganetzky, 1989)
(Brittnacher and Ganetzky, 1989)
(Brittnacher and Ganetzky, 1989)
hide Transgenic Constructs & Insertions
Transgenic Constructs
Type of construct
Name
Expression data
Insertions
Type of insertions
Name
Expression data
hide Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )
hide Terms Based on Experimental Evidence ( 0 terms )
hide Terms Based on Predictions or Assertions ( 0 terms )
hide Sequence Ontology: Class of Gene
gene
 
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Interacts with
Please look at the allele data for full details of the genetic interactions
l(2)41Ae allele
Gene
References
l(2)41Ae7
ct
(Rollins et al., 1999)
l(2)41Ae34-4
run
(Duffy et al., 1996)
unspecified
eve
(Duffy et al., 1996)
Kr
(Duffy et al., 1996)
hide External Data
Linkouts
DroID - A comprehensive database of gene and protein interactions.
•
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
•
hide Orthologs
hide OrthoDB Orthologs (0) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
OrthoDB orthology group searches
(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)
Drosophila inclusive ortholog search
No orthologs identified
Dipteran inclusive ortholog search
No orthologs identified
Insect inclusive ortholog search
No orthologs identified
Arthropod inclusive ortholog search
No orthologs identified
Metazoa inclusive ortholog search
No orthologs identified
Orthologs in Drosophila Species (None identified)
No orthologies identified
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
hide Human Orthologs (0)
Gene
OMIM
HGNC
hideAAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
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hide Genomic Clones ( 0 )
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cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
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Linkouts
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
•
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Source for database identity of
Source for database merge of
Additional comments
l(2)41Ae is NOT a single locus, but rather a large region (referred to as the '41Ae region') that is defined by the breakpoints of Df(2R)34-2 and includes the genes uex, Haspin, CG17683, CG40127 and CG17665.
(Coulthard et al., 2010)
The "l(2)41Ae" locus fails to complement mutations in 7 genes ("l(2)NC37", "l(2)NC38", "l(2)NC133", "l(2)NC110", "l(2)NC70", "l(2)IR3" and "l(2)IR23"). The "l(2)41Ae" locus has previously been shown to have complex complementation behaviour (FBrf0028786). This information suggests that the "l(2)41Ae""locus" may contain mutations in different genes.
(Dimitri et al., 2005)
The "l(2)41Ae" locus may be a deletion as it fails to complement seven different complementation groups isolated in this study.
(Myster et al., 2004)
'Nipped' mutations disrupt one or more of four recessive lethal complementation groups: l(2)41Ae, RpL38, Nipped-A and Nipped-B.
(Rollins et al., 1999)
Complementation map shaped like a figure eight and highly complex. Four heteroallelic combinations exhibit partial complementation: l(2)41Ae10/l(2)41Ae15 shows 17% survival, l(2)41Ae10/l(2)41Ae19 8% survival, l(2)41Ae9/l(2)41Ae28 10% survival and l(2)41Ae21/l(2)41Ae28 21% viability. The remaining combinations exhibit noncomplementation or complete complementation. In spite of the fact that among alleles l(2)41Ae35 to l(2)41Ae40, there is only one noncomplementing pair of alleles, l(2)41Ae35 and l(2)41Ae36, these mutants are designated alleles of l(2)41Ae on the basis of their inclusion in Df(2R)M41A4, Df(2R)M41A8, Df(2R)M41A10 and Df(2R)M41A50j and the extensive complementation characteristic of l(2)41Ae alleles.
 
hide Other Comments
'Nipped' mutations identify four essential complementation groups, l(2)41Ae, RpL38, Nipped-A and Nipped-B, that play distinct roles in regulating ct and N signalling.
(Rollins et al., 1999)
The Nipped-group genes regulate ct and Ubx.
(Rollins et al., 1997)
l(2)41Ae locus exhibits high EMS mutability and the lethal alleles exhibit a complex interallelic complementation.
(Hilliker, 1976)
Heterozygotes not Minute
 
hide External Crossreferences & Linkouts
Sequence Crossreferences
Other Crossreferences
Linkouts
DroID - A comprehensive database of gene and protein interactions.
•
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
•
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
•
hide Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym
41Ae
(Cenci et al., 2003, Dimitri et al., 2003)
GroupIV
(Ganetzky, 1977, Hilliker, 1976)
l(2)41Ae
(Dimitri et al., 2003, Coulthard et al., 2010)
l(2)C124
 
l(2)C147
 
l(2)EMS34-14
(Eberl et al., 1993)
l(2)Sp9b
 
l(2R)34-2
(Brittnacher and Ganetzky, 1989)
l(2R)A'
(Hilliker and Holm, 1975)
Name Synonym
lethal (2) 41Ae
 
Nipped
(Rollins et al., 1997)
Secondary FlyBase IDs
  • FBgn0002065
  • FBgn0002166
  • FBgn0002169
  • FBgn0020393
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