FlyBase Gene Report: Dmel\l(2)41Ae

General Information

Symbol

Dmel\l(2)41Ae

Species

D. melanogaster

Name

lethal (2) 41Ae

Annotation Symbol

Feature Type

gene

FlyBase ID

FBgn0004660

Gene Model Status

Unannotated

Stock Availability

None publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Red Book
Interactive Fly

Also Known As

41Ae, GroupIV

Function

Gene Ontology (GO) Annotations (0 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

l(2)41Ae

Heterozygotes not Minute. Complementation map shaped like a figure eight and highly complex. Four heteroallelic combinations exhibit partial complementation: l(2)41Ae10/l(2)41Ae15 shows 17% survival, l(2)41Ae10/l(2)41Ae19 8% survival, l(2)41Ae9/l(2)41Ae28 10% survival, and l(2)41Ae21/l(2)41Ae28 21% viability. The remaining combinations exhibit noncomplementation or complete complementation. In spite of the fact that among alleles l(2)41Ae35 to l(2)41Ae40, there is only one noncomplementing pair of alleles, l(2)41Ae35 and l(2)41Ae36, these mutants are designated alleles of l(2)41Ae on the basis of their inclusion in Df(2R)M41A-4, Df(2R)M41A-8, Df(2R)M41A-10, and Df(2R)M41A-50j and the extensive complementation characteristic of l(2)41Ae alleles.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Transcript Data

Annotated Transcripts

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Polypeptides with Identical Sequences

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\l(2)41Ae using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

NA

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\l(2)41Ae in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\l(2)41Ae

View exonic expression by tissue for Dmel\l(2)41Ae

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 37 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 0 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of l(2)41Ae

Transgenic constructs containing regulatory region of l(2)41Ae

Aberrations (Deficiencies and Duplications) ( 67 )

Inferred from experimentation ( 67 )

Gene disrupted in

Df(2R)M41A4

(Duffy et al., 1996, Koryakov and Zhimulev, 1996, Eberl et al., 1993, Sharp et al., 1985, Ganetzky, 1977, Hilliker, 1976, Hilliker and Holm, 1975)

Df(2R)M41A8

(Rollins et al., 1999, Dimitri et al., 1997, Koryakov and Zhimulev, 1996, Sharp et al., 1985, Hilliker and Holm, 1975)

Df(2R)M41A10

(Rollins et al., 1999, Duffy et al., 1996, Koryakov and Zhimulev, 1996, Eberl et al., 1993, Ganetzky, 1977, Hilliker, 1976, Hilliker and Holm, 1975)

Df(2R)Nipped-E43

(Rollins et al., 1999)

Df(2R)Nipped-E299.1

(Rollins et al., 1999)

Df(2R)Nipped-E338

(Rollins et al., 1999)

Df(2R)rl-1G

(Ganetzky, 1977, Hilliker, 1976)

Df(2R)rl-4J

(Ganetzky, 1977, Hilliker, 1976)

Df(2R)rl-5B

(Ganetzky, 1977, Hilliker, 1976)

Df(2R)rl-12E

(Ganetzky, 1977, Hilliker, 1976)

Df(2R)rl-13D

(Ganetzky, 1977, Hilliker, 1976)

Df(2R)rl-F

(Ganetzky, 1977, Hilliker, 1976)

Gene not disrupted in

Df(2L)F

(Hilliker and Holm, 1975)

Df(2R)B

(Ganetzky, 1977, Hilliker, 1976)

Df(2R)Nipped-A^C25

(Rollins et al., 1999)

Df(2R)Nipped-C160.1

(Rollins et al., 1999)

Df(2R)Nipped-D263.3

(Rollins et al., 1999)

Df(2R)Nipped-D341.1

(Rollins et al., 1999)

Df(2R)PR50

(Eberl et al., 1993)

Df(2R)PRB

(Eberl et al., 1993)

Df(2R)PRF

(Eberl et al., 1993)

Df(2R)rl-2J

(Ganetzky, 1977, Hilliker, 1976)

Df(2R)rl-6C

(Ganetzky, 1977, Hilliker, 1976)

Df(2R)rl-9B

(Hilliker, 1976)

Df(2R)rl-10G

(Rollins et al., 1999, Ganetzky, 1977, Hilliker, 1976)

Df(2R)rl-14C

(Ganetzky, 1977, Hilliker, 1976)

(Hilliker, 1976)

(Hilliker, 1976)

(Hilliker, 1976)

(Hilliker, 1976)

(Ganetzky, 1977)

(Ganetzky, 1977)

(Ganetzky, 1977)

(Rollins et al., 1999)

T(Y;2)B

(Dimitri, 1991)

Ts(Y;2Lt)C+Ts(Y;2Rt)A

(Dimitri, 1991)

Gene duplicated in

Dp(2;f)e24

(Brittnacher and Ganetzky, 1989)

Dp(2;f)e57

(Brittnacher and Ganetzky, 1989)

Dp(2;f)e97

(Brittnacher and Ganetzky, 1989)

Dp(2;f)f45

(Brittnacher and Ganetzky, 1989)

Dp(2;f)f82

(Brittnacher and Ganetzky, 1989)

Gene not duplicated in

Dp(2;f)e1

(Brittnacher and Ganetzky, 1989)

Dp(2;f)e5

(Brittnacher and Ganetzky, 1989)

Dp(2;f)e29

(Brittnacher and Ganetzky, 1989)

Dp(2;f)e44

(Brittnacher and Ganetzky, 1989)

Dp(2;f)e51

(Brittnacher and Ganetzky, 1989)

Dp(2;f)e55

(Brittnacher and Ganetzky, 1989)

Dp(2;f)e58

(Brittnacher and Ganetzky, 1989)

Dp(2;f)e61

(Brittnacher and Ganetzky, 1989)

Dp(2;f)e70

(Brittnacher and Ganetzky, 1989)

Dp(2;f)e72

(Brittnacher and Ganetzky, 1989)

Dp(2;f)e74

(Brittnacher and Ganetzky, 1989)

Dp(2;f)e83

(Brittnacher and Ganetzky, 1989)

Dp(2;f)e87

(Brittnacher and Ganetzky, 1989)

Dp(2;f)f6

(Brittnacher and Ganetzky, 1989)

Dp(2;f)f15

(Brittnacher and Ganetzky, 1989)

Dp(2;f)f29

(Brittnacher and Ganetzky, 1989)

Dp(2;f)f48

(Brittnacher and Ganetzky, 1989)

Dp(2;f)f49

(Brittnacher and Ganetzky, 1989)

Dp(2;f)f52

(Brittnacher and Ganetzky, 1989)

Dp(2;f)f53

(Brittnacher and Ganetzky, 1989)

Dp(2;f)f62

(Brittnacher and Ganetzky, 1989)

Dp(2;f)f67

(Brittnacher and Ganetzky, 1989)

Dp(2;f)f74

(Brittnacher and Ganetzky, 1989)

Dp(2;f)f77

(Brittnacher and Ganetzky, 1989)

Dp(2;f)f80

(Brittnacher and Ganetzky, 1989)

Dp(2;f)f84

(Brittnacher and Ganetzky, 1989)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal (with l(2)41Ae¹⁶)

l(2)41Ae¹⁷

lethal (with l(2)41Ae¹⁷)

l(2)41Ae¹⁶

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (0)

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (0)

Mus musculus (laboratory mouse) (0)

Xenopus tropicalis (Western clawed frog) (0)

Danio rerio (Zebrafish) (0)

Caenorhabditis elegans (Nematode, roundworm) (0)

Anopheles gambiae (African malaria mosquito) (0)

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:l(2)41Ae. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Other Interaction Browsers

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

run

enhanceable

l(2)41Ae

(Duffy et al., 1996)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0004660

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-55.1

Cytogenetic map

h45-h46

Sequence location

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

h45-h46

Left limit from non-inclusion within Tp(2;Y)Rsp31 (FBrf0030142) Right limit from inclusion within Df(2R)rl-5B (FBrf0028786)

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

h35-h35

(determined by in situ hybridisation)

(Dimitri, 1991)

Experimentally Determined Recombination Data

Location

(Rollins et al., 1998, Rollins et al., 1997)

2-55.1

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (0)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Genomic Clones (0)

cDNA Clones (0)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

'Nipped' mutations identify four essential complementation groups, l(2)41Ae, RpL38, Nipped-A and Nipped-B, that play distinct roles in regulating ct and N signalling.

(Rollins et al., 1999)

The Nipped-group genes regulate ct and Ubx.

(Rollins et al., 1997)

l(2)41Ae locus exhibits high EMS mutability and the lethal alleles exhibit a complex interallelic complementation.

(Hilliker, 1976)

Heterozygotes not Minute

Relationship to Other Genes

Source for database merge of

Additional comments

l(2)41Ae is NOT a single locus, but rather a large region (referred to as the '41Ae region') that is defined by the breakpoints of Df(2R)34-2 and includes the genes uex, Haspin, CG17683, CG40127 and CG17665.

(Coulthard et al., 2010)

The "l(2)41Ae" locus fails to complement mutations in 7 genes ("l(2)NC37", "l(2)NC38", "l(2)NC133", "l(2)NC110", "l(2)NC70", "l(2)IR3" and "l(2)IR23"). The "l(2)41Ae" locus has previously been shown to have complex complementation behaviour (FBrf0028786). This information suggests that the "l(2)41Ae" "locus" may contain mutations in different genes.

(Dimitri et al., 2005)

The "l(2)41Ae" locus may be a deletion as it fails to complement seven different complementation groups isolated in this study.

(Myster et al., 2004)

'Nipped' mutations disrupt one or more of four recessive lethal complementation groups: l(2)41Ae, RpL38, Nipped-A and Nipped-B.

(Rollins et al., 1999)

Complementation map shaped like a figure eight and highly complex. Four heteroallelic combinations exhibit partial complementation: l(2)41Ae¹⁰/l(2)41Ae¹⁵ shows 17% survival, l(2)41Ae¹⁰/l(2)41Ae¹⁹ 8% survival, l(2)41Ae⁹/l(2)41Ae²⁸ 10% survival and l(2)41Ae²¹/l(2)41Ae²⁸ 21% viability. The remaining combinations exhibit noncomplementation or complete complementation. In spite of the fact that among alleles l(2)41Ae³⁵ to l(2)41Ae⁴⁰, there is only one noncomplementing pair of alleles, l(2)41Ae³⁵ and l(2)41Ae³⁶, these mutants are designated alleles of l(2)41Ae on the basis of their inclusion in Df(2R)M41A4, Df(2R)M41A8, Df(2R)M41A10 and Df(2R)M41A50j and the extensive complementation characteristic of l(2)41Ae alleles.

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

41Ae

(Cenci et al., 2003, Dimitri et al., 2003)

GroupIV

(Ganetzky, 1977, Hilliker, 1976)

l(2)41Ae

(Coulthard et al., 2010, Dimitri et al., 2003)

l(2)C124

l(2)C147

l(2)EMS34-14

(Eberl et al., 1993)

l(2)Sp9b

l(2R)34-2

(Brittnacher and Ganetzky, 1989)

l(2R)A'

(Hilliker and Holm, 1975)

Name Synonyms

Nipped

(Rollins et al., 1997)

lethal (2) 41Ae

Secondary FlyBase IDs

FBgn0002065
FBgn0002166
FBgn0002169
FBgn0020393

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 1 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0004660

References (28)

NA

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