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Gene Dmel\inaC

General Information
Symbol	Dmel\inaC	Species	D. melanogaster
Name	inactivation no afterpotential C	Annotation symbol	CG6518
Feature type	protein_coding_gene	FlyBase ID	FBgn0004784
Gene Model Status	Current	Stock availability	13 publicly available
Also Known As	PKC, eye-PKC, eye PKC, PKCi, dPKC53E(ey)
Genomic Location
Chromosome (arm)	2R	Recombination map	2-82
Cytogenetic map	53E1-53E1	Sequence location	2R:12,786,040..12,789,080 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene inactivation no afterpotential C is referred to in FlyBase by the symbol Dmel\inaC (CG6518, FBgn0004784). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: female gonad development; adaptation of rhodopsin mediated signaling; phototransduction; response to ethanol; response to light stimulus; detection of light stimulus involved in sensory perception; cellular component movement; deactivation of rhodopsin mediated signaling; phospholipase C-inhibiting G-protein coupled receptor signaling pathway; phagocytosis, engulfment. 21 alleles are reported. The phenotypes of these alleles are annotated with: photoreceptor; eye; retina; ovary; gustatory receptor neuron; ovarian sheath; photoreceptor cell; egg chamber; germarium. It has one annotated transcript and one annotated polypeptide. Protein features are: AGC-kinase, C-terminal; C2 calcium-dependent membrane targeting; C2 calcium/lipid-binding domain, CaLB; C2 domain; C2 membrane targeting protein; Diacylglycerol/phorbol-ester binding; Protein kinase C, alpha/beta/gamma types; Protein kinase C-like, phorbol ester/diacylglycerol binding; Protein kinase, ATP binding site; Protein kinase, C-terminal; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine- / dual specificity protein kinase, catalytic domain; Serine/threonine-protein kinase, active site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of no expression detected. Peak expression observed during late pupal stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye. Comments on Affy2 ProbeSet: ProbeSet 1637807_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of inaC. Gene sequence location is 2R:12786040..12789080.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	inaC (J.C. Hall) Same basic phenotype as inaA; also, inaC lacks off transient of ERG, and (in such physiological recordings) there is a slow return to baseline potential at stimulus offset. Pkc2: Protein kinase-c2: Structural gene for protein kinase C (PKC); expressed primarily in photoreceptors of adult flies.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 53E1-53E1   Limits computationally determined from genome sequence between P{lacW}CG6426k10209&P{lacW}vegk07202 and P{lacW}l(2)k07408k07408
Experimentally Determined Cytological Location
Cytogenetic map Notes References 53E-53E   (determined by in situ hybridisation)   (Smith et al., 1991) 53E4-53E7   inaC maps within 50kb of Pkc53E. (determined by in situ hybridisation)   (Schaeffer et al., 1989)
Experimentally Determined Recombination Data
Location	2-82
Left of (cM)
Right of (cM)	L
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\inaC for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) inaC-RA FBtr0087047  NM_057515   2351   700
Additional Transcript Data & Comments
Reported size (kB)	2.5 (northern blot) (Schaeffer et al., 1989)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein inaC-PA   FBpp0086196   79.8   700   7.48     NP_476863   AAF57934
Additional Polypeptide Data & Comments
Reported size (kDa)	700 (aa) (Schaeffer et al., 1989)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • C2 membrane targeting protein (IPR018029) C2 calcium-dependent membrane targeting (IPR000008) Protein kinase, catalytic domain (IPR000719) AGC-kinase, C-terminal (IPR000961) Protein kinase C-like, phorbol ester/diacylglycerol binding (IPR002219) Serine/threonine- / dual specificity protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) C2 calcium/lipid-binding domain, CaLB (IPR008973) Protein kinase-like domain (IPR011009) Protein kinase C, alpha/beta/gamma types (IPR014375) Protein kinase, ATP binding site (IPR017441) Protein kinase, C-terminal (IPR017892) Diacylglycerol/phorbol-ester binding (IPR020454) C2 domain (IPR020477)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF57934   AC004641   AI062670   AI107141   AI107755   AI238312   AI238906   AI387164   AI387790   AI388713   AI389010   AI403006   AI403653   AI404920   AI404945   AI405179   AI517825   AW940954   BI243244   BI568749   BI572910   BI572917   BI585345   BI585347   BI589498   BI589512   BI589518   BI589527   BI628068   BT004495 AAO42659   CO178935   CO189915   CO196622   CO266662   CO266733   CO272259   CO277872   CO279547   CO300913   CO315241   CO333041   EC051036   EC052022   EC052396   EC053901   EC053909   EC054382   EC055287   EC055992   EC056054   EC056080   EC057960   EC067842   EC069815   EC071812   EC084545   EC085223   EC088453   EC198326   EC209608   EC216685   EC228762   EC234389   EC244395   EC244961   EC249775   EC249861   EL870465   EL876485   EL876820   EL885376   EV591147   J04845 AAA28817
UniProtKB/Swiss-Prot	P13677
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
expression microarray Stage Tissue/Position (including subcellular localization) Reference adult stage | male     (Arbeitman et al., 2004) adult stage   eye   (Xu et al., 2004) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 13 -- 16   Bolwig organ   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference pupal stage | late     (Schaeffer et al., 1989) adult stage   photoreceptor cell   (Schaeffer et al., 1989)   (Schaeffer et al., 1989) eye   (Schaeffer et al., 1989) ocellus   (Schaeffer et al., 1989) head   (Schaeffer et al., 1989)
Additional Descriptive Data
	Eye-enriched transcripts determined by ratio of expression level in wild-type heads. versus expression level in so heads. (Xu et al., 2004) inaC transcripts are detected in late pupae and adults by northern blots. In adults they are found in RNA from heads but not bodies. In situ hybridization shows that they are specific to photoreceptor cells and are expressed in both the eye and the ocelli. (Schaeffer et al., 1989)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference adult stage   rhabdomere   (Smith et al., 1991) eye   (Smith et al., 1991) ocellus   (Smith et al., 1991) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
	inaC protein is localized to the photoreceptor cells in both compound eyes and ocelli. Most of the signal is confined to the rhabdomeres of the photoreceptor cells. An inaC-:-Ecol\lacZ reporter construct was used to show that it is expressed in all types of photoreceptor cells in the eye and ocelli. (Smith et al., 1991)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
plasma membrane inferred from direct assay (Khanna et al., 2010) rhabdomere inferred from direct assay (Smith et al., 1991, Wang et al., 2005)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    3.675 Larval Midgut    2.5 Larval Hindgut    3.5 Larval Malpighian Tubules    2.6 Larval Fat Body    7 Larval Salivary Gland    2.8 Larval Trachea    80.6 Larval Carcass    3.025 Adult Head    1548 Adult Eye    5030.375 Adult Brain    96.8 Adult Thoracic-Abdominal Ganglion    3.7 Adult Crop    2.9 Adult Midgut    6.2 Adult Hindgut    3.5 Adult Malpighian Tubules    1.5 Adult Fat Body    3.1 Adult Salivary Gland    5.1 Adult Heart    7.45 Adult VirginFemale Spermatheca    1.5 Adult InseminatedFemale Spermatheca    4 Adult Ovary    1.8 Adult Testis    2.6 Adult Male Accessory Gland    37.5 Adult Carcass    3.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    3.675 Larval Midgut    2.5 Larval Hindgut    3.5 Larval Malpighian Tubules    2.6 Larval Fat Body    7 Larval Salivary Gland    2.8 Larval Trachea    80.6 Larval Carcass    3.025 Adult Head  (1548) Adult Eye  (5030.375) Adult Brain    96.8 Adult Thoracic-Abdominal Ganglion    3.7 Adult Crop    2.9 Adult Midgut    6.2 Adult Hindgut    3.5 Adult Malpighian Tubules    1.5 Adult Fat Body    3.1 Adult Salivary Gland    5.1 Adult Heart    7.45 Adult VirginFemale Spermatheca    1.5 Adult InseminatedFemale Spermatheca    4 Adult Ovary    1.8 Adult Testis    2.6 Adult Male Accessory Gland    37.5 Adult Carcass    3.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    3.675 Larval Midgut    2.5 Larval Hindgut    3.5 Larval Malpighian Tubules    2.6 Larval Fat Body    7 Larval Salivary Gland    2.8 Larval Trachea    80.6 Larval Carcass    3.025 Adult Head  (1548) Adult Eye  (5030.375) Adult Brain    96.8 Adult Thoracic-Abdominal Ganglion    3.7 Adult Crop    2.9 Adult Midgut    6.2 Adult Hindgut    3.5 Adult Malpighian Tubules    1.5 Adult Fat Body    3.1 Adult Salivary Gland    5.1 Adult Heart    7.45 Adult VirginFemale Spermatheca    1.5 Adult InseminatedFemale Spermatheca    4 Adult Ovary    1.8 Adult Testis    2.6 Adult Male Accessory Gland    37.5 Adult Carcass    3.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    3.675 Larval Midgut    2.5 Larval Hindgut    3.5 Larval Malpighian Tubules    2.6 Larval Fat Body    7 Larval Salivary Gland    2.8 Larval Trachea    80.6 Larval Carcass    3.025 Adult Head    1548 Adult Eye    5030.375 Adult Brain    96.8 Adult Thoracic-Abdominal Ganglion    3.7 Adult Crop    2.9 Adult Midgut    6.2 Adult Hindgut    3.5 Adult Malpighian Tubules    1.5 Adult Fat Body    3.1 Adult Salivary Gland    5.1 Adult Heart    7.45 Adult VirginFemale Spermatheca    1.5 Adult InseminatedFemale Spermatheca    4 Adult Ovary    1.8 Adult Testis    2.6 Adult Male Accessory Gland    37.5 Adult Carcass    3.4 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    3.675 Larval Midgut    2.5 Larval Hindgut    3.5 Larval Malpighian Tubules    2.6 Larval Fat Body    7 Larval Salivary Gland    2.8 Larval Trachea    80.6 Larval Carcass    3.025 Adult Head    1548 Adult Eye    5030.375 Adult Brain    96.8 Adult Thoracic-Abdominal Ganglion    3.7 Adult Crop    2.9 Adult Midgut    6.2 Adult Hindgut    3.5 Adult Malpighian Tubules    1.5 Adult Fat Body    3.1 Adult Salivary Gland    5.1 Adult Heart    7.45 Adult VirginFemale Spermatheca    1.5 Adult InseminatedFemale Spermatheca    4 Adult Ovary    1.8 Adult Testis    2.6 Adult Male Accessory Gland    37.5 Adult Carcass    3.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    3.675 Larval Midgut    2.5 Larval Hindgut    3.5 Larval Malpighian Tubules    2.6 Larval Fat Body    7 Larval Salivary Gland    2.8 Larval Trachea    80.6 Larval Carcass    3.025 Adult Head  (1548) Adult Eye  (5030.375) Adult Brain    96.8 Adult Thoracic-Abdominal Ganglion    3.7 Adult Crop    2.9 Adult Midgut    6.2 Adult Hindgut    3.5 Adult Malpighian Tubules    1.5 Adult Fat Body    3.1 Adult Salivary Gland    5.1 Adult Heart    7.45 Adult VirginFemale Spermatheca    1.5 Adult InseminatedFemale Spermatheca    4 Adult Ovary    1.8 Adult Testis    2.6 Adult Male Accessory Gland    37.5 Adult Carcass    3.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    3.675 Larval Midgut    2.5 Larval Hindgut    3.5 Larval Malpighian Tubules    2.6 Larval Fat Body    7 Larval Salivary Gland    2.8 Larval Trachea    80.6 Larval Carcass    3.025 Adult Head  1548 Adult Eye  (5030.375) Adult Brain    96.8 Adult Thoracic-Abdominal Ganglion    3.7 Adult Crop    2.9 Adult Midgut    6.2 Adult Hindgut    3.5 Adult Malpighian Tubules    1.5 Adult Fat Body    3.1 Adult Salivary Gland    5.1 Adult Heart    7.45 Adult VirginFemale Spermatheca    1.5 Adult InseminatedFemale Spermatheca    4 Adult Ovary    1.8 Adult Testis    2.6 Adult Male Accessory Gland    37.5 Adult Carcass    3.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    3.675 Larval Midgut    2.5 Larval Hindgut    3.5 Larval Malpighian Tubules    2.6 Larval Fat Body    7 Larval Salivary Gland    2.8 Larval Trachea    80.6 Larval Carcass    3.025 Adult Head    1548 Adult Eye    5030.375 Adult Brain    96.8 Adult Thoracic-Abdominal Ganglion    3.7 Adult Crop    2.9 Adult Midgut    6.2 Adult Hindgut    3.5 Adult Malpighian Tubules    1.5 Adult Fat Body    3.1 Adult Salivary Gland    5.1 Adult Heart    7.45 Adult VirginFemale Spermatheca    1.5 Adult InseminatedFemale Spermatheca    4 Adult Ovary    1.8 Adult Testis    2.6 Adult Male Accessory Gland    37.5 Adult Carcass    3.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1548   NA  Eye    5030.375   NA  Brain    96.8   3.675  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    3.7   NA  Crop    2.9   2.5  Midgut    6.2   3.5  Hindgut    3.5   2.6  Malpighian Tubules    1.5   7  Fat Body    3.1   2.8  Salivary Gland    5.1   NA  Heart    7.45   no informative data  Trachea    NA   NA  VirginFemale Spermatheca    1.5   NA  InseminatedFemale Spermatheca    4   NA  Ovary    1.8   NA  Testis    2.6   NA  Male Accessory Gland    37.5   3.025  Carcass    3.4 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    4 head, virgin 1-day female    123 head, virgin 4-day female    115 head, virgin 20-day female    91 head, mated 1-day female    91 head, mated 4-day female    100 head, mated 20-day female    75 head, mated 1-day male    134 head, mated 4-day male    160 head, mated 20-day male    153 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    4 head, virgin 1-day female  (123) head, virgin 4-day female  (115) head, virgin 20-day female  (91) head, mated 1-day female  (91) head, mated 4-day female  (100) head, mated 20-day female  (75) head, mated 1-day male  (134) head, mated 4-day male  (160) head, mated 20-day male  (153) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    4 head, virgin 1-day female  (123) head, virgin 4-day female  (115) head, virgin 20-day female    91 head, mated 1-day female    91 head, mated 4-day female    100 head, mated 20-day female    75 head, mated 1-day male  (134) head, mated 4-day male  (160) head, mated 20-day male  (153) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    4 head, virgin 1-day female    123 head, virgin 4-day female    115 head, virgin 20-day female    91 head, mated 1-day female    91 head, mated 4-day female    100 head, mated 20-day female    75 head, mated 1-day male    134 head, mated 4-day male    160 head, mated 20-day male    153 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    4 head, virgin 1-day female    123 head, virgin 4-day female    115 head, virgin 20-day female    91 head, mated 1-day female    91 head, mated 4-day female    100 head, mated 20-day female    75 head, mated 1-day male    134 head, mated 4-day male    160 head, mated 20-day male    153 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    4 head, virgin 1-day female  (123) head, virgin 4-day female  (115) head, virgin 20-day female  (91) head, mated 1-day female  (91) head, mated 4-day female  (100) head, mated 20-day female  (75) head, mated 1-day male  (134) head, mated 4-day male  (160) head, mated 20-day male  (153) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    4 head, virgin 1-day female  123 head, virgin 4-day female  115 head, virgin 20-day female    91 head, mated 1-day female    91 head, mated 4-day female    100 head, mated 20-day female    75 head, mated 1-day male  134 head, mated 4-day male  (160) head, mated 20-day male  (153) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    4 head, virgin 1-day female    123 head, virgin 4-day female    115 head, virgin 20-day female    91 head, mated 1-day female    91 head, mated 4-day female    100 head, mated 20-day female    75 head, mated 1-day male    134 head, mated 4-day male    160 head, mated 20-day male    153 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of no expression detected. Peak expression observed during late pupal stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    3 white prepupae 24hr    4 pupae 2d postWPP    13 pupae 3d postWPP    46 pupae 4d postWPP    24 adult male 01day    41 adult male 05day    40 adult male 30day    43 adult female 01day    17 adult female 05day    10 adult female 30day    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    3 white prepupae 24hr    4 pupae 2d postWPP    13 pupae 3d postWPP  (46) pupae 4d postWPP    24 adult male 01day  (41) adult male 05day  (40) adult male 30day  (43) adult female 01day    17 adult female 05day    10 adult female 30day    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    3 white prepupae 24hr    4 pupae 2d postWPP    13 pupae 3d postWPP    46 pupae 4d postWPP    24 adult male 01day    41 adult male 05day    40 adult male 30day    43 adult female 01day    17 adult female 05day    10 adult female 30day    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    3 white prepupae 24hr    4 pupae 2d postWPP    13 pupae 3d postWPP    46 pupae 4d postWPP    24 adult male 01day    41 adult male 05day    40 adult male 30day    43 adult female 01day    17 adult female 05day    10 adult female 30day    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    3 white prepupae 24hr    4 pupae 2d postWPP    13 pupae 3d postWPP    46 pupae 4d postWPP    24 adult male 01day    41 adult male 05day    40 adult male 30day    43 adult female 01day    17 adult female 05day    10 adult female 30day    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    3 white prepupae 24hr    4 pupae 2d postWPP    13 pupae 3d postWPP  (46) pupae 4d postWPP    24 adult male 01day  (41) adult male 05day  (40) adult male 30day  (43) adult female 01day    17 adult female 05day    10 adult female 30day    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    3 white prepupae 24hr    4 pupae 2d postWPP    13 pupae 3d postWPP    46 pupae 4d postWPP    24 adult male 01day    41 adult male 05day    40 adult male 30day    43 adult female 01day    17 adult female 05day    10 adult female 30day    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    3 white prepupae 24hr    4 pupae 2d postWPP    13 pupae 3d postWPP    46 pupae 4d postWPP    24 adult male 01day    41 adult male 05day    40 adult male 30day    43 adult female 01day    17 adult female 05day    10 adult female 30day    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_00
External Data & Images
Linkouts	BDGP expression data • GH24781 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004784 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6518-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable inaCe00783 viable, with Scer\GAL4pnr-MD237 inaCGD1328 Sterility Allele fertile inaCe00783 Other Phenotypes Allele behavior defective, with Scer\GAL4hs.PB inaCPKCi.Scer\UAS chemical resistant, with Scer\GAL4npf.1 inaCPKCi.Scer\UAS neurophysiology defective inaC2 neurophysiology defective, with Scer\GAL4MJ94 inaCPKCi.Scer\UAS neurophysiology defective | recessive inaC2 neurophysiology defective | semidominant inaC2 visual behavior defective inaC2 visual behavior defective | recessive inaC2 wild-type inaC+tSa inaChs.PA Phenotype manifest in Allele egg chamber, with Scer\GAL4ptc-559.1 inaCPKCi.Scer\UAS eye inaC2 germarium, with Scer\GAL4ptc-559.1 inaCPKCi.Scer\UAS gustatory receptor neuron, with Scer\GAL4MJ94 inaCPKCi.Scer\UAS ovarian sheath, with Scer\GAL4ptc-559.1 inaCPKCi.Scer\UAS ovary, with Scer\GAL4ptc-559.1 inaCPKCi.Scer\UAS photoreceptor inaC2 photoreceptor cell inaC1 inaC2 retina inaC2
Classical Alleles ( 9 )
For All Classical Alleles Show
Allele of inaC Class Mutagen Stocks Known lesion inaCe00783 piggyBac transposase 2 -- inaC2 amorphic allele - genetic evidence ethyl methanesulfonate 1 Yes inaC1 ethyl methanesulfonate 1 Yes inaC3 ethyl methanesulfonate 0 -- inaC4 ethyl methanesulfonate 0 -- inaC5 ethyl methanesulfonate 0 Yes inaC6 ethyl methanesulfonate 0 -- inaC7 ethyl methanesulfonate 0 -- inaC8 ethyl methanesulfonate 0 --
Alleles Carried on Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Allele of inaC Class Mutagen Stocks Known lesion inaCGD1328 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes inaCPKCi.Scer\UAS in vitro construct - regulatory fusion 2 Yes inaCJF01212 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes inaCJF01443 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes inaCJF02391 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes inaCJF02958 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes inaCKK105562 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes inaC+tSa in vitro construct - genomic fragment 0 Yes inaC6.8.T:Ecol\lacZ in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes inaChs.PA in vitro construct - regulatory fusion 0 Yes inaCI700D.hs in vitro construct - regulatory fusion 0 Yes inaCNIG.6518R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel6065 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data heat-shock construct P{hs-inaC.A} NA P{hs-inaC.I700D} NA UAS construct P{GD1328} NA P{KK105562} NA P{NIG.6518R} NA P{TRiP.JF01212} NA P{TRiP.JF01443} NA P{TRiP.JF02391} NA P{TRiP.JF02958} NA P{UAS-PKCi.B} NA reporter construct P{eye-PKC-LacZ} No characterization construct P{eye-PKC} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{RB}inaCe00783 NA
Gene Ontology: Function, Process & Cellular Component ( 23 unique terms )
Terms Based on Experimental Evidence ( 13 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with UniProtKB:Q24008 (assigned by UniProtKB) (Kumar and Shieh, 2001)
Biological Process
CV term Evidence References
adaptation of rhodopsin mediated signaling inferred from mutant phenotype (Smith et al., 1991, Hardie et al., 1993, Ranganathan et al., 1991) cellular component movement inferred from mutant phenotype (Cohen et al., 2002) deactivation of rhodopsin mediated signaling inferred from mutant phenotype (Smith et al., 1991, Hardie et al., 1993, Ranganathan et al., 1991) detection of light stimulus involved in sensory perception inferred from mutant phenotype (Popescu et al., 2006) female gonad development inferred from mutant phenotype (Cohen et al., 2002) phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006) phospholipase C-inhibiting G-protein coupled receptor signaling pathway inferred from mutant phenotype (Gu et al., 2005) phototransduction inferred from genetic interaction with rdgB (Smith et al., 1991) inferred from mutant phenotype (Fitzgibbon and Hunt, 1995) response to ethanol inferred from direct assay (Chen et al., 2008) response to light stimulus inferred from mutant phenotype (Wang et al., 2008)
Cellular Component
CV term Evidence References
plasma membrane inferred from direct assay (Khanna et al., 2010) rhabdomere inferred from direct assay (Smith et al., 1991, Wang et al., 2005)
Terms Based on Predictions or Assertions ( 12 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR000961, InterPro:IPR002290, InterPro:IPR014375, InterPro:IPR017441, InterPro:IPR017892 (FlyBase Curators et al., 2004-) calcium-dependent protein kinase C activity non-traceable author statement (Swiss-Prot Project Members, 1990.4.1) diacylglycerol binding inferred from sequence or structural similarity with InterPro:IPR002219 (FlyBase, 1992-) protein kinase C activity inferred from sequence or structural similarity with EMBL:M18330 (Schaeffer et al., 1989) non-traceable author statement (Swiss-Prot Project Members, 1990.4.1) protein serine/threonine kinase activity non-traceable author statement (Morrison et al., 2000) zinc ion binding inferred from electronic annotation with InterPro:IPR014375 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
adaptation of rhodopsin mediated signaling non-traceable author statement (Montell, 1999) calcium-mediated signaling traceable author statement (Montell, 1999) deactivation of rhodopsin mediated signaling non-traceable author statement (Swiss-Prot Project Members, 1990.4.1) traceable author statement (Hardie, 2001, Montell, 1999) intracellular signal transduction inferred from electronic annotation with InterPro:IPR002219 (FlyBase Curators et al., 2004-) protein phosphorylation inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR000961, InterPro:IPR002290, InterPro:IPR008271, InterPro:IPR014375, InterPro:IPR017892 (FlyBase Curators et al., 2004-) non-traceable author statement (Morrison et al., 2000)
Cellular Component
CV term Evidence References
inaD signaling complex traceable author statement (Montell, 1999, Harteneck, 2003)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
inaC - 128up anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - ATPsyn-γ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - Aats-ile anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - Arpc2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - Atx2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - BCAS2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - CG10077 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - CG10306 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - CG11107 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - CG11266 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - CG13220 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - CG15220 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - CG15735 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - CG2021 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - CG34163 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - CG3689 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - CG40045 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - CG4169 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - CG4553 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - CG4858 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - CG5746 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - CG6724 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - CG7033 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - CG8545 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - Cdc5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - Cyt-c-p anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - EfTuM anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - Gp210 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - Hsp23 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - Int6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - Jupiter anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - NHP2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - Ns1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - Ns2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - P32 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - Pgam5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - Pkc53E anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - Pp1-87B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - Prp8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - Rab2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - Rbp1-like anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - RpL24-like anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - RpL35A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - RpLP0 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - Rpd3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - Rpt5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - Rrp4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - Rrp40 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - SF1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - Saf-B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - Sec23 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - SmD3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - SmG anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - Tango7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - cathD anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - eIF3-S8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - flw anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - grp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - isoQC anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - kst anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - mRpL51 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - mRpL9 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - mRpS28 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - mts anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - nop5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - pic anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - sqh anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - tyf anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) inaC - α-Spec anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions inaC allele Gene References inaC2 rdgB (Smith et al., 1991)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62602 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0004784 DroID - A comprehensive database of gene and protein interactions. • FBgn0004784 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36897 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P13677
Orthologs
OrthoDB Orthologs (64) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6Z3706 Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search EOG61KB55
Orthologs in Drosophila Species (EOG6Z3706)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\inaC     Drosophila simulans   Dsim\GD11232 Y   Drosophila sechellia   Dsec\GM21738     Drosophila erecta   Dere\GG20644     Drosophila yakuba   Dyak\GE11833 Y   Drosophila ananassae   Dana\GF11423 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19657     Drosophila persimilis   Dper\GL11569 Y   Drosophila willistoni   Dwil\GK22030 Y   Drosophila virilis   Dvir\GJ21015 Y   Drosophila mojavensis   Dmoj\GI21162 Y   Drosophila grimshawi   Dgri\GH22649 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (EOG61KB55)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\E01H11.1 Y Caenorhabditis elegans Nematode  Cele\pkc-1 Y Caenorhabditis elegans Nematode  Cele\tpa-1 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027848gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_001049gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008678gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026498gn Y Danio rerio Zebrafish  Drer\prkcba Y Danio rerio Zebrafish  Drer\prkcq Y Danio rerio Zebrafish  Drer\BX005175.1 Y Danio rerio Zebrafish  Drer\prkceb Y Danio rerio Zebrafish  Drer\prkcea Y Danio rerio Zebrafish  Drer\prkchb Y Danio rerio Zebrafish  Drer\prkcbb Y Danio rerio Zebrafish  Drer\prkcg Y Danio rerio Zebrafish  Drer\prkca Y Danio rerio Zebrafish  Drer\ENSDARG00000086250 Y Danio rerio Zebrafish  Drer\prkcha Y Danio rerio Zebrafish  Drer\prkcd Y Xenopus tropicalis Western clawed frog  Xtro\prkcb Y Xenopus tropicalis Western clawed frog  Xtro\prkcd Y Xenopus tropicalis Western clawed frog  Xtro\prkch Y Xenopus tropicalis Western clawed frog  Xtro\prkcg Y Xenopus tropicalis Western clawed frog  Xtro\prkcq Y Xenopus tropicalis Western clawed frog  Xtro\prkce Y Gallus gallus Domestic chicken  Ggal\PRKCD Y Gallus gallus Domestic chicken  Ggal\PRKCA Y Gallus gallus Domestic chicken  Ggal\PRKCB Y Gallus gallus Domestic chicken  Ggal\PRKCH Y Gallus gallus Domestic chicken  Ggal\ENSGALG00000023876 Y Gallus gallus Domestic chicken  Ggal\PRKCE Y Mus musculus House mouse  Mmus\Prkcq Y Mus musculus House mouse  Mmus\Prkch Y Mus musculus House mouse  Mmus\ENSMUSG00000021948 Y Mus musculus House mouse  Mmus\Prkce Y Mus musculus House mouse  Mmus\Prkcc Y Mus musculus House mouse  Mmus\ENSMUSG00000052889 Y Mus musculus House mouse  Mmus\Prkca Y Rattus norvegicus Norway rat  Rnor\Prkch Y Rattus norvegicus Norway rat  Rnor\Prkca Y Rattus norvegicus Norway rat  Rnor\Prkce Y Rattus norvegicus Norway rat  Rnor\Prkcg Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000012061 Y Rattus norvegicus Norway rat  Rnor\Prkcd Y Rattus norvegicus Norway rat  Rnor\Prkcq Y Homo sapiens Human  Hsap\PRKCQ Y Homo sapiens Human  Hsap\PRKCD Y Homo sapiens Human  Hsap\PRKCE Y Homo sapiens Human  Hsap\PRKCH Y Homo sapiens Human  Hsap\PRKCA Y Homo sapiens Human  Hsap\PRKCG Y Homo sapiens Human  Hsap\PRKCB Y
Human Orthologs (7)
Gene OMIM HGNC Hsap\PRKCQ     Hsap\PRKCD     Hsap\PRKCE     Hsap\PRKCH     Hsap\PRKCA     Hsap\PRKCG     Hsap\PRKCB
AAA Orthologs (8) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD11232 Drosophila yakuba Dyak\GE11833 Drosophila ananassae Dana\GF11423 Drosophila persimilis Dper\GL11569 Drosophila willistoni Dwil\GK22030 Drosophila virilis Dvir\GJ21015 Drosophila mojavensis Dmoj\GI21162 Drosophila grimshawi Dgri\GH22649
Stocks & Reagents
Stocks Listed in FlyBase ( 13 )
Bloomington	42240 w*; inaC1 42241 w*; inaC2 4589 w*; P{UAS-PKCi.B}4A 17885 w1118; PBac{RB}inaCe00783 31271 y1 v1; P{TRiP.JF01212}attP2 31651 y1 v1; P{TRiP.JF01443}attP2 36776 y1 v1; P{TRiP.JF02391}attP2
Harvard	- PBac{RB}inaCe00783
Kyoto	107811 w*; P{UAS-PKCi.B}4A
VDRC	v101719 P{KK105562}VIE-260B v2895 w1118; P{GD1328}v2895 v2894 w1118; P{GD1328}v2894/TM3
	More stocks available...
Genomic Clones ( 2 )
	BACR03E17 BACR09M08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 53 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH24781
Other clones	DPiM_GH24781
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH01958 GH05596 GH06453 GH14335 GH15043 GH17615 GH18445 GH19696 GH20079 GH22359 GH23136 GH24820 GH25113 GH28889 RE40823 RH06974 RH07258 RH21748 RH21923 RH27868 RH29092 RH29556 RH30669 RH35623 RH66461
Other clones	Dmel_neb_013062_0338_2651 EC051036 EC052022 EC052396 EC053901 EC053909 EC054382 EC055287 EC055992 EC056054 EC056080 EK006908 EK045559 EK058010 EK106450 EK127323 EK135158 EK147156 EK147356 EK179652 EK239745 EK305524 IP02543 IP06437 IP06737 IP16627
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004784 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36897
Antibody Information
	polyclonal (Smith et al., 1991)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Authors show two copies of inaC are required for wild-type deactivation of the visual response, leading them to conclude inaC is haploinsufficient. (Wang et al., 2008) S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. (Stroschein-Stevenson et al., 2006) When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in mitotic index seen. (Bettencourt-Dias et al., 2004) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) The second PDZ domain of inaD protein interacts with the last three residues in the carboxyl-terminal tail of inaC protein. The in vivo activity of inaC protein depends on its association with inaD protein. (Adamski et al., 1998) Reflectance measurements performed on inaC and trp photoreceptor mutants confirm that the pupil can serve as a useful tool in fly phototransduction research. (Hofstee and Stavenga, 1996) inaC, the eye specific protein kinase C, is dispensable for the phosphorylation of Arr2 in vivo. (Matsumoto et al., 1994) Intracellular voltage clamping demonstrated that light adaptation is severely reduced in inaC mutants, suggesting that the eye specific PKC encoded by inaC is required for adaptation. Whole cell current recordings from isolated ommatidia showed that in the absence of PKC the single photon-induced quantum bumps fail to terminate normally. (Hardie et al., 1993) The protein kinase C (PKC) enzyme in Drosophila is encoded by a gene family made up of three genes which are expressed primarily in adult flies. The deduced amino acid sequences of these genes are quite similar to each other and those of the mammalian PKC family (Schaeffer et al., 1989).   Structural gene for protein kinase C (PKC). Isolated from Drosophila clones obtained with mammalian probes. Expressed primarily in photoreceptors of adult flies. Mutant alleles have same basic phenotype as inaA; also, inaC lacks off transient of ERG and (in such physiological recordings) there is a slow return to baseline potential at stimulus offset. Structural gene for protein kinase C (PKC); expressed primarily in photoreceptors of adult flies. Mutant alleles have same basic phenotype as inaA; also, inaC lacks off transient of ERG and (in such physiological recordings) there is a slow return to baseline potential at stimulus offset.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057515 RefSeq (Proteins) • NP_476863 DDBJ / EMBL / GenBank • AAA28817 AAF57934 AAO42659 AC004641 AI404920 AW940954 BT004495 J04845 Entrez Gene - A searchable database of RefSeq genes. • 36897 UniProtKB/Swiss-Prot • P13677
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • C2 membrane targeting protein (IPR018029) C2 calcium-dependent membrane targeting (IPR000008) Protein kinase, catalytic domain (IPR000719) AGC-kinase, C-terminal (IPR000961) Protein kinase C-like, phorbol ester/diacylglycerol binding (IPR002219) Serine/threonine- / dual specificity protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) C2 calcium/lipid-binding domain, CaLB (IPR008973) Protein kinase-like domain (IPR011009) Protein kinase C, alpha/beta/gamma types (IPR014375) Protein kinase, ATP binding site (IPR017441) Protein kinase, C-terminal (IPR017892) Diacylglycerol/phorbol-ester binding (IPR020454) C2 domain (IPR020477) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH24781
Linkouts
	BioGRID - A database of protein and genetic interactions • 62602 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0004784 DroID - A comprehensive database of gene and protein interactions. • FBgn0004784 DRSC - Results from RNAi screens. • FBgn0004784 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004784 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6518-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004784 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36897 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36897 modMine - Data generated by the modENCODE project. • FBgn0004784 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P13677
Synonyms & Secondary IDs ( 25 )
Reported As
Symbol Synonym	CG6518 (Arbeitman et al., 2004, Morrison et al., 2000, Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Ni et al., 2009, Khanna et al., 2010, Ni et al., 2008, Ni et al., 2010.12.1) Dpkc2 (Franke et al., 1994) dPKC53E (Siegfried et al., 1990) dPKC53E(ey) (Franke et al., 1994, Schaeffer et al., 1989, ) ePKC (Bahner et al., 2000) eye PKC (Hardie, 2001, Broughton et al., 1996) eye-PKC (Harris and Lim, 2001, Kumar and Shieh, 2001, Tsunoda et al., 2001, Liu et al., 2000, Adamski et al., 1998, Ranganathan and Ross, 1997, Tsunoda et al., 1997, Smith, 1996, Smith et al., 1991, Zuker, 1992, Sanxaridis et al., 2007, Popescu et al., 2006, Cronin et al., 2006, Peng et al., 2008) InaC (Pedra et al., 2004, Jaken, 2000) INAC (Delmas et al., 2004, Han et al., 2006, Kwon and Montell, 2006, Wang et al., 2005, Wang et al., 2008, Han et al., 2007) inaC (Yang et al., 2005, Wang et al., 2005, Hiesinger et al., 2006, Stroschein-Stevenson et al., 2006, Elsaesser et al., 2010, Sanxaridis et al., 2007, Mishra et al., 2007, Popescu et al., 2006, Landry et al., 2007, Bao and Friedrich, 2009, Guan et al., 2011, Cronin et al., 2004, Ni et al., 2009, Meyer et al., 2008, Venkatachalam et al., 2010, Mecklenburg et al., 2010, Voolstra et al., 2010, Wasbrough et al., 2010, Taraszka et al., 2005, Japanese National Institute of Genetics, 2012.5.21, Senthilan et al., 2012, Nfonsam et al., 2012) PKC (Mehren et al., 2004, Roderick and Bootman, 2003, Wheeler and Nijhout, 2003, Fanning and Anderson, 1999, Suh et al., 2001, Vanden Broeck, 2001, Greenspan and Ferveur, 2000, Xu et al., 1998, Montell, 1998, Brodu and Casanova, 2006, Nelson et al., 2005, Lee et al., 2009, Hall, 2003, Huang et al., 2010, Sanxaridis and Tsunoda, 2010, Venkatachalam et al., 2010, Chen et al., 2008) pkc-2 (Ranganathan et al., 1991) Pkc2   PKC 53E (Morrison et al., 2000) PKCi (Cohen et al., 2002, Chen et al., 2008) unnamed (Kane et al., 1997)
Name Synonym	eye-PKC (Wang et al., 2008) eye-protein-kinase C (Cronin et al., 2006) eye-specific PKC (Scott and Zuker, 1998) inactivation no afterpotential C (Ni et al., 2009, Wang et al., 2008, Baig et al., 2010) Inactivation no afterpotential C (Bao and Friedrich, 2009, Khanna et al., 2010) PKC-eye (Buchner, 1991) Protein-kinase-2   protein kinase C (Montell, 2000, Oliver et al., 1999, Nelson et al., 2005, Lee et al., 2009, Huang et al., 2010, Venkatachalam et al., 2010) protein-kinase-C (Hall, 2003) Protein kinase-c2
Secondary FlyBase IDs
	FBgn0001262 FBgn0003092
References ( 148 )
Generate a list of	All references relating to this gene ( 148 )
List References by type	Research paper  ( 78 ) Supplementary material  ( 8 ) Review  ( 36 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 6 ) FlyBase analysis  ( 2 ) Stock list  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 ) Letter  ( 1 )
Recent research papers ( 3 )
	Nfonsam et al., 2012, PLoS ONE 7(8): e44583 Analysis of the Transcriptomes Downstream of Eyeless and the Hedgehog, Decapentaplegic and Notch Signaling Pathways in Drosophila melanogaster. [FBrf0219414] Senthilan et al., 2012, Cell 150(5): 1042--1054 Drosophila auditory organ genes and genetic hearing defects. [FBrf0219321] Guan et al., 2011, Learn. Mem. 18(4): 191--206 Altered gene regulation and synaptic morphology in Drosophila learning and memory mutants. [FBrf0213277] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...