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Gene Dmel\retn

General Information
Symbol	Dmel\retn	Species	D. melanogaster
Name	retained	Annotation symbol	CG5403
Feature type	protein_coding_gene	FlyBase ID	FBgn0004795
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	dri, l(2)02535
Genomic Location
Chromosome (arm)	2R	Recombination map	2-
Cytogenetic map	59F5-59F5	Sequence location	2R:19,520,135..19,542,343 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene retained is referred to in FlyBase by the symbol Dmel\retn (CG5403, FBgn0004795). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: transcription regulatory region sequence-specific DNA binding; repressing transcription factor binding; DNA binding. There is experimental evidence that it is involved in the biological process: axon guidance; embryonic pattern specification; gliogenesis; muscle organ development; oogenesis; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; anterior/posterior pattern specification; male courtship behavior; regulation of female receptivity. 27 alleles are reported. The phenotypes of these alleles are annotated with: embryonic hindgut; embryonic/larval glial cell; adult mushroom body; interface glial cell; longitudinal connective; mushroom body beta-lobe; axon; embryonic/larval somatic muscle. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: ARID/BRIGHT DNA-binding domain; REKLES domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult eye, adult female reproductive system, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult hindgut, adult salivary gland. Comments on Affy2 ProbeSet: ProbeSet 1625481_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of retn. Gene sequence location is 2R:19520135..19542343.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features BKN28289 HFA04679 Controlled Vocabulary Terms embryonic/larval brain wing disc ventral nerve cord larval stage repressing transcription factor binding transcription regulatory region sequence-specific DNA binding posterior corpus allatum neuron epithelium lateral cord glial cell
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 59F5-59F5   Limits computationally determined from genome sequence between P{PZ}apt03041 and P{EP}eglEP938
Experimentally Determined Cytological Location
Cytogenetic map Notes References 59F2-59F4     (Gregory, 1996.6.27) 59F3-59F4   (determined by in situ hybridisation)   (Spradling et al., 1999) 59F3-59F4     (Beaton, 1997.12.27) 59F1-59F4   59F3--4   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	2- (Gregory, 1996.6.27)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\retn for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) retn-RA FBtr0072072  NM_057516   4289   906 retn-RB FBtr0072073  NM_176254   4304   911
Additional Transcript Data & Comments
Reported size (kB)	3.696 (compiled cDNA) (Gregory et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein retn-PA   FBpp0071981   96.8   906   6.13     NP_476864   AAF47037 retn-PB   FBpp0071982   97.4   911   6.20     NP_788434   AAO41347
Additional Polypeptide Data & Comments
Reported size (kDa)	901 (aa) (Gregory et al., 1996)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • ARID/BRIGHT DNA-binding domain (IPR001606) REKLES domain (IPR023334) PDB - Protein Data Bank. An information portal to biological macromolecular structures • 1C20 1KQQ
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202151   AA391966   AA439009   AA441156   AA949663   AA949802   AA950834   AE013599 AAF47037   AE013599 AAO41347   AC005639   AI455872   AI456624   AI514605   AI515768   AI518901   AI519077   AI520398   AI520423   AQ073271   AY118955 AAM50815   BG638563   BI162613   BI162614   BI234213   BI237353   BI239680   BI358056   BI483524   BI483554   CO177684   CO273111   CO277321   CO279954   CO283412   CO289530   CO295797   CO295868   CO303516   CO306132   CO307701   CO315045   CO324421   CZ488909   CZ488910   EC071926   EC074789   EC197065   EC203016   EC203161   EC203650   EC207119   EC209319   EC212889   EC226217   EC232260   EC245130   EC245345   EV579187   EV579508   EV592740   EV595751   EV596998   EV599629   GH941469   GH942955   GH945045   GH945125   GH948195   GH948997   GH949347   GH950863   GH950963   GH950969   GH951654   GH951862   GH951919   GH951978   GH952313   GH953438   GH953564   GH954122   GH955221   GH957018   GH959943   GH960194   GH960514   GH961004   GH961017   GH961157   GH961589   GH963034   GH963301   GH965412   GH965540   GH965667   GH966486   GH968232   GH969534   GH969930   GH970803   GH971004   GH973568   GH974433   GH977468   GH978931   GH979251   GH980457   GH981057   GH981367   GH981487   GH981618   U62542 AAB05771
UniProtKB/Swiss-Prot	Q24573
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 4   organism | ubiquitous   (Gregory et al., 1996) Comment:reference states <2 hr AEL embryonic stage 5 -- 6   organism | 40-60% egg length   (Gregory et al., 1996) Comment:reference states 2-3 hr AEL embryonic stage 5 -- 7   organism | 0-30% egg length   (Gregory et al., 1996) Comment:0-25% egg length organism | 70-100% egg length   (Gregory et al., 1996) Comment:75-100% egg length embryonic stage 6 -- 10   mesoderm   (Gregory et al., 1996) Comment:reference states 3-5 hr AEL embryonic stage 15 -- 16   posterior embryonic/larval midgut   (Gregory et al., 1996) labral segment   (Gregory et al., 1996) embryonic/larval salivary gland duct   (Gregory et al., 1996) anterior embryonic/larval midgut   (Gregory et al., 1996) embryonic/larval hindgut   (Gregory et al., 1996) pharyngeal muscle   (Gregory et al., 1996)
Additional Descriptive Data
	retn transcripts are expressed in a dynamic pattern during embryogenesis. They are distributed throughout the embryo during syncytial cleavage stages and at cellularization, are distributed in broad bands at the termini and in the center of the embryo. At germ band extension, the transcripts are found predominantly in the mesoderm and at later stages, are detected in the pharyngeal muscles, the amnioserosa, and in a distinct row of cells in the hindgut. They are also observed in the ring gland, in the clypeolabrum, in a ring of cells around the hindgut-midgut junction, and in several cells in each brain lobe. Ventrally, expression is observed in the salivary ducts, in a ring of cells at the foregut-midgut junction and in a repeated pattern in the CNS. (Gregory et al., 1996)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   presumptive embryonic salivary gland   (Haberman et al., 2003) embryonic stage 1 -- 4   organism | ubiquitous   (Gregory et al., 1996) Comment:reference states <2 hr AEL embryonic stage 3 -- 4   organism   • nucleus (Shandala et al., 1999) embryonic stage 4 -- 6   organism | 40-60% egg length   (Gregory et al., 1996) Comment:reference states 2-3 hr AEL embryonic stage 5 -- 6   organism | 0-30% egg length   (Gregory et al., 1996) Comment:reference states 2-3 hr AEL; 0-25% egg length organism | 70-100% egg length   (Gregory et al., 1996) Comment:reference specifies 75-100% egg length embryonic stage 6 -- 10   mesoderm   (Gregory et al., 1996) Comment:reference states 3-5 hr AEL embryonic stage 13 -- 14   large intestine primordium   (Iwaki et al., 2001) embryonic stage 15 -- 16   embryonic brain | restricted   (Gregory et al., 1996) amnioserosa   (Gregory et al., 1996) embryonic/larval foregut   (Gregory et al., 1996) embryonic ventral nervous system | segmentally repeated   (Gregory et al., 1996) ring gland   (Gregory et al., 1996) embryonic brain | posterior   (Shandala et al., 2002) neuron of ventral nerve cord   (Shandala et al., 2002) lateral cord glial cell   (Shandala et al., 2002) corpus allatum   (Shandala et al., 2002) epithelium | restricted of embryonic/larval hindgut   (Shandala et al., 2002) larval stage   embryonic/larval brain | posterior   (Shandala et al., 2002) epithelium of wing disc   (Shandala et al., 2002) adult stage | female   nurse cell   • nucleus (Shandala et al., 1999) oocyte   • nucleus (Shandala et al., 1999) follicle cell   • nucleus (Shandala et al., 1999)
Additional Descriptive Data
	retn protein is expressed in a dynamic pattern during embryogenesis. It is distributed evenly in syncytial nuclei and in contrast to the RNA is also uniformly distributed in late blastoderm embryos. At germ band extension, retn protein is found predominantly in the mesoderm. At later stages, protein is detected in the pharyngeal muscles, the amnioserosa, and in a distinct row of cells in the hindgut. It is also observed in the ring gland, clypeolabrum, a ring of cells around the hindgut-midgut junction, and several cells in each brain lobe. Ventrally, expression is observed in the salivary ducts, a ring of cells at the foregut-midgut junction and in a repeated pattern in the CNS. (Gregory et al., 1996)
Marker for
Subcellular Localization
CV Term	nucleus (Gregory et al., 1996)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0004795    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0004795 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0004795 expression level Developmental Stage   Expression Level embryo 00-02hr    13289 embryo 02-04hr    23820 embryo 04-06hr    8073 embryo 06-08hr    4646 embryo 08-10hr    4704 embryo 10-12hr    3536 embryo 12-14hr    3309 embryo 14-16hr    5081 embryo 16-18hr    3459 embryo 18-20hr    1574 embryo 20-22hr    4122 embryo 22-24hr    3748 larva L1    465 larva L2    295 larva L3 12hr old    134 larva L3 puffstage 1-2    109 larva L3 puffstage 3-6    238 larva L3 puffstage 7-9    299 white prepupae new    324 white prepupae 12hr    721 white prepupae 24hr    898 pupae 2d postWPP    615 pupae 3d postWPP    498 pupae 4d postWPP    639 adult male 01day    924 adult male 05day    1147 adult male 30day    1312 adult female 01day    3453 adult female 05day    6163 adult female 30day    6439 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (13289) embryo 02-04hr  (23820) embryo 04-06hr  (8073) embryo 06-08hr  (4646) embryo 08-10hr  (4704) embryo 10-12hr  (3536) embryo 12-14hr  (3309) embryo 14-16hr  (5081) embryo 16-18hr  (3459) embryo 18-20hr  (1574) embryo 20-22hr  (4122) embryo 22-24hr  (3748) larva L1  (465) larva L2  (295) larva L3 12hr old  (134) larva L3 puffstage 1-2  (109) larva L3 puffstage 3-6  (238) larva L3 puffstage 7-9  (299) white prepupae new  (324) white prepupae 12hr  (721) white prepupae 24hr  (898) pupae 2d postWPP  (615) pupae 3d postWPP  (498) pupae 4d postWPP  (639) adult male 01day  (924) adult male 05day  (1147) adult male 30day  (1312) adult female 01day  (3453) adult female 05day  (6163) adult female 30day  (6439) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (13289) embryo 02-04hr  (23820) embryo 04-06hr  (8073) embryo 06-08hr  (4646) embryo 08-10hr  (4704) embryo 10-12hr  (3536) embryo 12-14hr  (3309) embryo 14-16hr  (5081) embryo 16-18hr  (3459) embryo 18-20hr  (1574) embryo 20-22hr  (4122) embryo 22-24hr  (3748) larva L1    465 larva L2    295 larva L3 12hr old    134 larva L3 puffstage 1-2    109 larva L3 puffstage 3-6    238 larva L3 puffstage 7-9    299 white prepupae new    324 white prepupae 12hr    721 white prepupae 24hr    898 pupae 2d postWPP    615 pupae 3d postWPP    498 pupae 4d postWPP    639 adult male 01day    924 adult male 05day    1147 adult male 30day    1312 adult female 01day  (3453) adult female 05day  (6163) adult female 30day  (6439) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (13289) embryo 02-04hr  (23820) embryo 04-06hr    8073 embryo 06-08hr    4646 embryo 08-10hr    4704 embryo 10-12hr    3536 embryo 12-14hr    3309 embryo 14-16hr    5081 embryo 16-18hr    3459 embryo 18-20hr    1574 embryo 20-22hr    4122 embryo 22-24hr    3748 larva L1    465 larva L2    295 larva L3 12hr old    134 larva L3 puffstage 1-2    109 larva L3 puffstage 3-6    238 larva L3 puffstage 7-9    299 white prepupae new    324 white prepupae 12hr    721 white prepupae 24hr    898 pupae 2d postWPP    615 pupae 3d postWPP    498 pupae 4d postWPP    639 adult male 01day    924 adult male 05day    1147 adult male 30day    1312 adult female 01day    3453 adult female 05day    6163 adult female 30day    6439 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    13289 embryo 02-04hr    23820 embryo 04-06hr    8073 embryo 06-08hr    4646 embryo 08-10hr    4704 embryo 10-12hr    3536 embryo 12-14hr    3309 embryo 14-16hr    5081 embryo 16-18hr    3459 embryo 18-20hr    1574 embryo 20-22hr    4122 embryo 22-24hr    3748 larva L1    465 larva L2    295 larva L3 12hr old    134 larva L3 puffstage 1-2    109 larva L3 puffstage 3-6    238 larva L3 puffstage 7-9    299 white prepupae new    324 white prepupae 12hr    721 white prepupae 24hr    898 pupae 2d postWPP    615 pupae 3d postWPP    498 pupae 4d postWPP    639 adult male 01day    924 adult male 05day    1147 adult male 30day    1312 adult female 01day    3453 adult female 05day    6163 adult female 30day    6439 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0004795 expression level Developmental Stage   Expression Level embryo 00-02hr    13289 embryo 02-04hr    23820 embryo 04-06hr    8073 embryo 06-08hr    4646 embryo 08-10hr    4704 embryo 10-12hr    3536 embryo 12-14hr    3309 embryo 14-16hr    5081 embryo 16-18hr    3459 embryo 18-20hr    1574 embryo 20-22hr    4122 embryo 22-24hr    3748 larva L1    465 larva L2    295 larva L3 12hr old    134 larva L3 puffstage 1-2    109 larva L3 puffstage 3-6    238 larva L3 puffstage 7-9    299 white prepupae new    324 white prepupae 12hr    721 white prepupae 24hr    898 pupae 2d postWPP    615 pupae 3d postWPP    498 pupae 4d postWPP    639 adult male 01day    924 adult male 05day    1147 adult male 30day    1312 adult female 01day    3453 adult female 05day    6163 adult female 30day    6439 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (13289) embryo 02-04hr  (23820) embryo 04-06hr  (8073) embryo 06-08hr  (4646) embryo 08-10hr  (4704) embryo 10-12hr  (3536) embryo 12-14hr  (3309) embryo 14-16hr  (5081) embryo 16-18hr  (3459) embryo 18-20hr  (1574) embryo 20-22hr  (4122) embryo 22-24hr  (3748) larva L1  (465) larva L2  (295) larva L3 12hr old  134 larva L3 puffstage 1-2  109 larva L3 puffstage 3-6  (238) larva L3 puffstage 7-9  (299) white prepupae new  (324) white prepupae 12hr  (721) white prepupae 24hr  (898) pupae 2d postWPP  (615) pupae 3d postWPP  (498) pupae 4d postWPP  (639) adult male 01day  (924) adult male 05day  (1147) adult male 30day  (1312) adult female 01day  (3453) adult female 05day  (6163) adult female 30day  (6439) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (13289) embryo 02-04hr  (23820) embryo 04-06hr  (8073) embryo 06-08hr  (4646) embryo 08-10hr  (4704) embryo 10-12hr  (3536) embryo 12-14hr  (3309) embryo 14-16hr  (5081) embryo 16-18hr  (3459) embryo 18-20hr  1574 embryo 20-22hr  (4122) embryo 22-24hr  (3748) larva L1    465 larva L2    295 larva L3 12hr old    134 larva L3 puffstage 1-2    109 larva L3 puffstage 3-6    238 larva L3 puffstage 7-9    299 white prepupae new    324 white prepupae 12hr    721 white prepupae 24hr    898 pupae 2d postWPP    615 pupae 3d postWPP    498 pupae 4d postWPP    639 adult male 01day    924 adult male 05day    1147 adult male 30day    1312 adult female 01day  (3453) adult female 05day  (6163) adult female 30day  (6439) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  13289 embryo 02-04hr  (23820) embryo 04-06hr    8073 embryo 06-08hr    4646 embryo 08-10hr    4704 embryo 10-12hr    3536 embryo 12-14hr    3309 embryo 14-16hr    5081 embryo 16-18hr    3459 embryo 18-20hr    1574 embryo 20-22hr    4122 embryo 22-24hr    3748 larva L1    465 larva L2    295 larva L3 12hr old    134 larva L3 puffstage 1-2    109 larva L3 puffstage 3-6    238 larva L3 puffstage 7-9    299 white prepupae new    324 white prepupae 12hr    721 white prepupae 24hr    898 pupae 2d postWPP    615 pupae 3d postWPP    498 pupae 4d postWPP    639 adult male 01day    924 adult male 05day    1147 adult male 30day    1312 adult female 01day    3453 adult female 05day    6163 adult female 30day    6439 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    13289 embryo 02-04hr    23820 embryo 04-06hr    8073 embryo 06-08hr    4646 embryo 08-10hr    4704 embryo 10-12hr    3536 embryo 12-14hr    3309 embryo 14-16hr    5081 embryo 16-18hr    3459 embryo 18-20hr    1574 embryo 20-22hr    4122 embryo 22-24hr    3748 larva L1    465 larva L2    295 larva L3 12hr old    134 larva L3 puffstage 1-2    109 larva L3 puffstage 3-6    238 larva L3 puffstage 7-9    299 white prepupae new    324 white prepupae 12hr    721 white prepupae 24hr    898 pupae 2d postWPP    615 pupae 3d postWPP    498 pupae 4d postWPP    639 adult male 01day    924 adult male 05day    1147 adult male 30day    1312 adult female 01day    3453 adult female 05day    6163 adult female 30day    6439 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0004795    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0004795 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult eye, adult female reproductive system, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult hindgut, adult salivary gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0004795 expression level Tissue   Expression Level Larval Central Nervous System    29.5 Larval Midgut    15.1 Larval Hindgut    234.7 Larval Malpighian Tubules    9.9 Larval Fat Body no informative data Larval Salivary Gland    67.4 Larval Trachea    11.525 Larval Carcass    34.5 Adult Head    228.2 Adult Eye    676.225 Adult Brain    48.4 Adult Thoracic-Abdominal Ganglion    50.1 Adult Crop no informative data Adult Midgut    75.6 Adult Hindgut    458.7 Adult Malpighian Tubules no informative data Adult Fat Body    9.8 Adult Salivary Gland    112.2 Adult Heart    4.8 Adult VirginFemale Spermatheca    950.7 Adult InseminatedFemale Spermatheca    1056.3 Adult Ovary    1252.8 Adult Testis    62.4 Adult Male Accessory Gland    729 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    29.5 Larval Midgut    15.1 Larval Hindgut    234.7 Larval Malpighian Tubules    9.9 Larval Fat Body no informative data Larval Salivary Gland    67.4 Larval Trachea    11.525 Larval Carcass    34.5 Adult Head    228.2 Adult Eye  (676.225) Adult Brain    48.4 Adult Thoracic-Abdominal Ganglion    50.1 Adult Crop no informative data Adult Midgut    75.6 Adult Hindgut    458.7 Adult Malpighian Tubules no informative data Adult Fat Body    9.8 Adult Salivary Gland    112.2 Adult Heart    4.8 Adult VirginFemale Spermatheca  (950.7) Adult InseminatedFemale Spermatheca  (1056.3) Adult Ovary  (1252.8) Adult Testis    62.4 Adult Male Accessory Gland  (729) Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    29.5 Larval Midgut    15.1 Larval Hindgut    234.7 Larval Malpighian Tubules    9.9 Larval Fat Body no informative data Larval Salivary Gland    67.4 Larval Trachea    11.525 Larval Carcass    34.5 Adult Head    228.2 Adult Eye    676.225 Adult Brain    48.4 Adult Thoracic-Abdominal Ganglion    50.1 Adult Crop no informative data Adult Midgut    75.6 Adult Hindgut    458.7 Adult Malpighian Tubules no informative data Adult Fat Body    9.8 Adult Salivary Gland    112.2 Adult Heart    4.8 Adult VirginFemale Spermatheca    950.7 Adult InseminatedFemale Spermatheca  1056.3 Adult Ovary  (1252.8) Adult Testis    62.4 Adult Male Accessory Gland    729 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    29.5 Larval Midgut    15.1 Larval Hindgut    234.7 Larval Malpighian Tubules    9.9 Larval Fat Body no informative data Larval Salivary Gland    67.4 Larval Trachea    11.525 Larval Carcass    34.5 Adult Head    228.2 Adult Eye    676.225 Adult Brain    48.4 Adult Thoracic-Abdominal Ganglion    50.1 Adult Crop no informative data Adult Midgut    75.6 Adult Hindgut    458.7 Adult Malpighian Tubules no informative data Adult Fat Body    9.8 Adult Salivary Gland    112.2 Adult Heart    4.8 Adult VirginFemale Spermatheca    950.7 Adult InseminatedFemale Spermatheca    1056.3 Adult Ovary    1252.8 Adult Testis    62.4 Adult Male Accessory Gland    729 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0004795 expression level Tissue   Expression Level Larval Central Nervous System    29.5 Larval Midgut    15.1 Larval Hindgut    234.7 Larval Malpighian Tubules    9.9 Larval Fat Body no informative data Larval Salivary Gland    67.4 Larval Trachea    11.525 Larval Carcass    34.5 Adult Head    228.2 Adult Eye    676.225 Adult Brain    48.4 Adult Thoracic-Abdominal Ganglion    50.1 Adult Crop no informative data Adult Midgut    75.6 Adult Hindgut    458.7 Adult Malpighian Tubules no informative data Adult Fat Body    9.8 Adult Salivary Gland    112.2 Adult Heart    4.8 Adult VirginFemale Spermatheca    950.7 Adult InseminatedFemale Spermatheca    1056.3 Adult Ovary    1252.8 Adult Testis    62.4 Adult Male Accessory Gland    729 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    29.5 Larval Midgut    15.1 Larval Hindgut    234.7 Larval Malpighian Tubules    9.9 Larval Fat Body no informative data Larval Salivary Gland    67.4 Larval Trachea    11.525 Larval Carcass    34.5 Adult Head    228.2 Adult Eye  676.225 Adult Brain    48.4 Adult Thoracic-Abdominal Ganglion    50.1 Adult Crop no informative data Adult Midgut    75.6 Adult Hindgut    458.7 Adult Malpighian Tubules no informative data Adult Fat Body    9.8 Adult Salivary Gland    112.2 Adult Heart    4.8 Adult VirginFemale Spermatheca  (950.7) Adult InseminatedFemale Spermatheca  (1056.3) Adult Ovary  (1252.8) Adult Testis    62.4 Adult Male Accessory Gland  729 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    29.5 Larval Midgut    15.1 Larval Hindgut    234.7 Larval Malpighian Tubules    9.9 Larval Fat Body no informative data Larval Salivary Gland    67.4 Larval Trachea    11.525 Larval Carcass    34.5 Adult Head    228.2 Adult Eye    676.225 Adult Brain    48.4 Adult Thoracic-Abdominal Ganglion    50.1 Adult Crop no informative data Adult Midgut    75.6 Adult Hindgut    458.7 Adult Malpighian Tubules no informative data Adult Fat Body    9.8 Adult Salivary Gland    112.2 Adult Heart    4.8 Adult VirginFemale Spermatheca    950.7 Adult InseminatedFemale Spermatheca  1056.3 Adult Ovary  1252.8 Adult Testis    62.4 Adult Male Accessory Gland    729 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    29.5 Larval Midgut    15.1 Larval Hindgut    234.7 Larval Malpighian Tubules    9.9 Larval Fat Body no informative data Larval Salivary Gland    67.4 Larval Trachea    11.525 Larval Carcass    34.5 Adult Head    228.2 Adult Eye    676.225 Adult Brain    48.4 Adult Thoracic-Abdominal Ganglion    50.1 Adult Crop no informative data Adult Midgut    75.6 Adult Hindgut    458.7 Adult Malpighian Tubules no informative data Adult Fat Body    9.8 Adult Salivary Gland    112.2 Adult Heart    4.8 Adult VirginFemale Spermatheca    950.7 Adult InseminatedFemale Spermatheca    1056.3 Adult Ovary    1252.8 Adult Testis    62.4 Adult Male Accessory Gland    729 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop no informative data Adult Midgut     Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    228.2   NA  Eye    676.225   NA  Brain    48.4   29.5  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    50.1   NA  Crop    no informative data   15.1  Midgut    75.6   234.7  Hindgut    458.7   9.9  Malpighian Tubules    no informative data   no informative data  Fat Body    9.8   67.4  Salivary Gland    112.2   NA  Heart    4.8   11.525  Trachea    NA   NA  VirginFemale Spermatheca    950.7   NA  InseminatedFemale Spermatheca    1056.3   NA  Ovary    1252.8   NA  Testis    62.4   NA  Male Accessory Gland    729   34.5  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_01
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004795 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5403-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for retn Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage | partially | recessive | rescuable maternal effect retn1 retn2 lethal | embryonic stage | recessive retn02535 retn05096 lethal | partially (with retn1) retnRU50 retnz2-428 lethal | partially (with retn2) retnRU50 retnz2-428 lethal | partially (with retn89.GAL4) retnz2-428 lethal | partially (with retnRU50) retn1 retn2 lethal | partially (with retnz2-428) retn1 retn2 retn89.GAL4 lethal | recessive retn2R-R971 retn02535 retn05096 retnB142 retnx1N793 semi-lethal retn02535 Sterility Allele female sterile retnRO44 retnRU50 fertile | female | reduced retnz2-428 Other Phenotypes Allele behavior defective | female retnz2-428 courtship behavior defective | female (with retn2) retnRU50 retnz2-428 courtship behavior defective | female (with retn05096) retnz2-428 courtship behavior defective | female (with retnRU50) retn2 retnz2-428 courtship behavior defective | female (with retnz2-428) retn2 retn05096 retnRU50 neuroanatomy defective, with Scer\GAL4MZ1580 retnScer\UAS.cSa neuroanatomy defective (with retn1) retn2 neuroanatomy defective (with retn2) retn1 neuroanatomy defective | somatic clone | third instar larval stage retnJ1609 retnR971 Phenotype manifest in Allele adult mushroom body retnRO44 adult mushroom body (with retn89.GAL4) retnz2-428 adult mushroom body (with retn05096) retnz2-428 adult mushroom body (with retnz2-428) retn05096 retn89.GAL4 axon, with Scer\GAL4MZ1580 retnScer\UAS.cSa cephalopharyngeal skeleton | germline clone retn1 retn2 dorsal closure embryo | germline clone retn1 retn2 egg | germline clone retn1 retn2 embryonic/larval glial cell, with Scer\GAL4MZ1580 retnScer\UAS.cSa embryonic/larval hindgut | embryonic stage retn02535 retn1 embryonic/larval pericardial cell | germline clone retn1 retn2 embryonic/larval somatic muscle retn1 retn2 embryonic hindgut retnunspecified embryonic hindgut, with Scer\GAL4byn-Gal4 retnScer\UAS.cSa embryonic segment | germline clone retn1 retn2 extended germ band embryo | germline clone retn1 retn2 hypostomal sclerite | germline clone retn1 retn2 interface glial cell (with retn1) retn2 interface glial cell (with retn2) retn1 lateral process | germline clone retn1 retn2 longitudinal connective (with retn1) retn2 longitudinal connective (with retn2) retn1 mushroom body beta-lobe retnRO44 mushroom body beta-lobe (with retn89.GAL4) retnz2-428 mushroom body beta-lobe (with retn05096) retnz2-428 mushroom body beta-lobe (with retnz2-428) retn05096 retn89.GAL4 neuron | somatic clone retn2R-J1609 retn2R-R971 pharyngeal muscle | germline clone retn1 retn2 photoreceptor cell R1 | somatic clone retn89.GAL4 photoreceptor cell R2 | somatic clone retn89.GAL4 photoreceptor cell R3 | somatic clone retn89.GAL4 photoreceptor cell R4 | somatic clone retn89.GAL4 photoreceptor cell R5 | somatic clone retn89.GAL4 photoreceptor cell R6 | somatic clone retn89.GAL4 somatic muscle | germline clone retn1 retn2 subesophageal ganglion | somatic clone retn89.GAL4 syncytial blastoderm embryo | germline clone retn1 retn2
Classical Alleles ( 22 )
For All Classical Alleles Show
Allele of retn Class Mutagen Stocks Known lesion retnRO44 ethyl methanesulfonate 2 Yes retn02535 P-element activity 1 Yes retn1 ethyl methanesulfonate 1 Yes retnf06245 piggyBac transposase 1 -- retn05096 P-element activity 0 Yes retn108.GAL4 gene conversion 0 Yes retn117.GAL4 gene conversion 0 Yes retn139.GAL4 gene conversion 0 Yes retn28.GAL4 gene conversion 0 Yes retn2 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- retn2R-J1609 0 -- retn2R-R971 chemical 0 Yes retn89.GAL4 gene conversion 0 Yes retnB142 X ray ethyl methanesulfonate 0 Yes retnGAL4 gene conversion 0 Yes retnJ1609 ethyl methanesulfonate 0 Yes retnP1 P-element activity 0 -- retnR971 ethyl methanesulfonate 0 Yes retnRU50 ethyl methanesulfonate 0 Yes retnunspecified 0 -- retnx1N793 X ray ethyl methanesulfonate 0 -- retnz2-428 0 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of retn Class Mutagen Stocks Known lesion retnGLV21053 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes retnJF02082 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes retnKK108289 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes retnGMR.PB in vitro construct - regulatory fusion 0 Yes retnScer\UAS.cSa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)BSC659 (Christensen et al., 2008.12.28) Df(2R)BSC665 (Christensen et al., 2008.12.28) Df(2R)BSC695 (Christensen et al., 2008.12.28) Df(2R)BSC779 (Christensen et al., 2009.5.6) Df(2R)bwVDe2LPxKR (Spradling et al., 1999, BDGP Project Members, 1994-1999, Beaton, 1997.12.27) Df(2R)bw-D23 (Schupbach and Wieschaus, 1991) Df(2R)bw-S46 (Spradling et al., 1999, Schupbach and Wieschaus, 1991, BDGP Project Members, 1994-1999) Df(2R)Exel7180 (Ryder, 2004.4.26) Df(2R)tid (Shandala et al., 1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK108289} NA P{TRiP.GLV21053} NA P{TRiP.JF02082} NA characterization construct P{GMR-retn.B} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacZ}retnP1 No P{PZ}retn02535 No P{PZ}retn05096 No miscellaneous insertions PBac{WH}retnf06245 NA insertion of enhancer trap binary system P{GawB}retn28.GAL4 No P{GawB}retn89.GAL4 No P{GawB}retn108.GAL4 No P{GawB}retn117.GAL4 No P{GawB}retn139.GAL4 No P{GawB}retnGAL4 No
Gene Ontology: Function, Process & Cellular Component ( 17 unique terms )
Terms Based on Experimental Evidence ( 14 terms )
Molecular Function
CV term Evidence References
DNA binding inferred from direct assay (Gregory et al., 1996) inferred from direct assay (assigned by UniProtKB) (Iwahara et al., 2002) repressing transcription factor binding inferred from physical interaction with gro (Valentine et al., 1998) transcription regulatory region sequence-specific DNA binding inferred from direct assay (Valentine et al., 1998)
Biological Process
CV term Evidence References
anterior/posterior pattern specification inferred from mutant phenotype (Shandala et al., 1999) axon guidance inferred from mutant phenotype (Ditch et al., 2005, Berger et al., 2008) embryonic pattern specification inferred from mutant phenotype (Shandala et al., 1999) gliogenesis inferred from mutant phenotype (assigned by UniProtKB) (Shandala et al., 2003) male courtship behavior inferred from mutant phenotype (Ditch et al., 2005) muscle organ development inferred from mutant phenotype (Shandala et al., 1999) negative regulation of transcription from RNA polymerase II promoter inferred from mutant phenotype (Valentine et al., 1998) oogenesis inferred from mutant phenotype (Schupbach and Wieschaus, 1991) positive regulation of transcription, DNA-dependent inferred from mutant phenotype (assigned by UniProtKB) (Shandala et al., 2003) regulation of female receptivity inferred from mutant phenotype (Ditch et al., 2005)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Gregory et al., 1996, Valentine et al., 1998)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
DNA binding non-traceable author statement (Gregory, 1996.6.27) sequence-specific DNA binding transcription factor activity non-traceable author statement (Bradley et al., 2001)
Biological Process
CV term Evidence References
negative regulation of transcription from RNA polymerase II promoter non-traceable author statement (Courey and Jia, 2001) salivary gland development non-traceable author statement (Abrams et al., 2003) salivary gland morphogenesis non-traceable author statement (Bradley et al., 2001)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions retn allele Gene References retn02535 peb (Wilk et al., 2004) retnB142 aop (Rebay et al., 2000) Ras85D (Rebay et al., 2000) retnx1N793 aop (Rebay et al., 2000) phl (Rebay et al., 2000) Ras85D (Rebay et al., 2000)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 70031 DroID - A comprehensive database of gene and protein interactions. • FBgn0004795 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45976
Orthologs
Genome-wide drosophilid orthologs	Dana\GF13069 Dere\GG22872 Dgri\GH20664 Dmoj\GI19027 Dper\GL16874 Dpse\GA18855 Dsec\GM16032 Dsim\GD11780 Dvir\GJ19993 Dwil\GK23065 Dyak\GE14310
Curated drosophilid orthologs	Dpse\GA18855
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL010648-PA Aedes aegypti (mosquito) AGAP005156-PA Anopheles gambiae (mosquito) XP_001121514.1 Apis mellifera (honey bee) ENSBTAP00000011354 Bos taurus (bovine) CN23167 Caenorhabditis brenneri (small nematode) CBP34304 Caenorhabditis briggsae (nematode) CE31068 Caenorhabditis elegans (worm) ENSCAFP00000029071 Canis familiaris (dog) JA15976 Caenorhabditis japonica (nematode) CPIJ014253 Culex pipens (mosquito) ENSCPOP00000010633 Cavia porcellus (guinea pig) RP48943 Caenorhabditis remanei (nematode) ENSCSAVP00000014825 Ciona savignyi (sedentary tunicate) ENSDARP00000088317 Danio rerio (zebra fish) ENSGACP00000011075 Gymnopilus aculeatus (mushroom) ENSGALP00000002095 Gallus gallus (chicken) ENSP00000263620 Homo sapiens (human) ENSMODP00000007047 Monodelphis domestica (gray opossum) ENSMMUP00000027359 Macaca mulatta (rhesus monkey) ENSMUSP00000019708 Mus musculus (house mouse) XP_001600051.1 Nasonia vitripennis (wasp) ENSORLP00000010296 Oryzias latipes (japanese killifish) LOC_Os06g41730.1 Oryza sativa (asian rice) ENSPPYP00000010436 Pongo pygmaeus (orangutan) ENSRNOP00000039046 Rattus norvegicus (norway rat) 57024 Trichoplax adhaerens (metazoa) ENSTNIP00000009503 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000043756 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000057283 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0231925 FBgn0225027 FBgn0207134 FBgn0193644 FBgn0183519 FBgn0248832 FBgn0078855 FBgn0162841 FBgn0162770 FBgn0154478 FBgn0144475 FBgn0141766 FBgn0141447 FBgn0140433 FBgn0137713 FBgn0128127 FBgn0115029 FBgn0090102
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	26309 y1 v1; P{TRiP.JF02082}attP2 7097 al1 b1 c1 retn1/CyO 11200 cn1 P{PZ}retn02535/CyO; ry506 5106 cn1 bw1 retnRO44/CyO, l(2)DTS5131 35688 y1 sc* v1; P{TRiP.GLV21053}attP2/TM3, Sb1
Harvard	- PBac{WH}retnf06245
Kyoto	108045 cn1 bw1 retnRO44/CyO, l(2)DTS5131
VDRC	v100579 P{KK108289}VIE-260B
Genomic Clones ( 1 )
	BACR48M01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 102 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD35748
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD02276 LD10918 LD13429 LD16053 LD29824 LD30977 LD35593 LD36707 LD38349 LD40546 LD40579 LD41431 LD46135 RE29874 RE33570 RE36243 RE44723 RE66435 RE66465
Other clones	4938 10330 10394 39086 43367 66068 78213 119367 121628 144377 149561 CK01.66D.C6 CK01.91A.D12 Dmel_dig_008988_0705_2668 Dmel_dig_013196_0642_3123 Dmel_neb_004178_0897_2729 Dmel_neb_006525_0629_1189 Dmel_neb_006869_0869_3120 Dmel_neb_009504_0663_2684 EK054043 EK071248 EK109559 EK123825 EK152046 EK163061 EK193628 EK211615 EK211902 EK238843 EK241923 EK250327 EK255311 LD29637 RE01886 RP004067771 RP004101421 RP004120150 RP004127396 RP004129786 RP004145969 RP004151129 RP004151794 RP004152933 RP004154934 RP004163958 RP004166543 RP004167994 RP004186487 RP004192293 RP004199259 RP004230835 RP004231022 RP004232248 RP004235076 RP004235154 RP004235265 RP004240416 RP004252676 RP004254230 RP004256695 RP004267782 RP004290893 RP004363305 RP004379416 RP004419003 RP004421577 RP004435214 RP004440698 RP004457968 RP004479553 RP004488446 RP004490339 RP004492343 RP004515983 RP004519073 RP004533032 RP004538219 RP004539693 RP004539879 RP004544504 RP004547781 RP004551320
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004795 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45976
Antibody Information
	polyclonal (Gregory et al., 1996, Shandala et al., 1999)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: dri CG5403 (Zhang, 1999.11)
Source for database merge of	Source for merge of: dri l(2)02535 (Shandala et al., 1999) Source for merge of: retn BcDNA:LD35748 (Ditch et al., 2001, FlyBase, 1996-)
Additional comments	Source for merge of retn BcDNA:LD35748 was a shared cDNA (date:030728). (Ditch et al., 2001, FlyBase, 1996-) cDNA sequence of "l(2)02535" is in large parts identical to "dri" sequence. (Gerisch and Korge, 1997)
Other Comments
	retn is required for positioning of the longitudinal glia in the embryonic central nervous system. (Shandala et al., 2003) retn is essential for anterior-posterior patterning and for muscle development in the embryo. (Shandala et al., 1999) Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland. (Harvie et al., 1998) retn has been cloned and sequenced, and its expression pattern has been analysed. (Gregory et al., 1996) Identified in a screen for clones which bind an en homeodomain binding site. (Gregory et al., 1995) Mutations at the retn locus cause defects in midoogenesis. (Schupbach and Wieschaus, 1991)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057516 NM_176254 RefSeq (Proteins) • NP_476864 NP_788434 DDBJ / EMBL / GenBank • AAB05771 AAF47037 AAM50815 AAO41347 AC005639 AI518901 AQ073271 AY118955 CZ488909 CZ488910 U62542 Entrez Gene - A searchable database of RefSeq genes. • 45976 UniProtKB/Swiss-Prot • Q24573
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • ARID/BRIGHT DNA-binding domain (IPR001606) REKLES domain (IPR023334) PDB - Protein Data Bank. An information portal to biological macromolecular structures • 1C20 1KQQ
Linkouts
	BioGRID - A database of protein and genetic interactions • 70031 DroID - A comprehensive database of gene and protein interactions. • FBgn0004795 DRSC - Results from RNAi screens. • FBgn0004795 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004795 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5403-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004795 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45976 InParanoid A subset of ortholog calls from InParanoid. • AAEL010648-PA Aedes aegypti (mosquito) AGAP005156-PA Anopheles gambiae (mosquito) XP_001121514.1 Apis mellifera (honey bee) ENSBTAP00000011354 Bos taurus (bovine) CN23167 Caenorhabditis brenneri (small nematode) CBP34304 Caenorhabditis briggsae (nematode) CE31068 Caenorhabditis elegans (worm) ENSCAFP00000029071 Canis familiaris (dog) JA15976 Caenorhabditis japonica (nematode) CPIJ014253 Culex pipens (mosquito) ENSCPOP00000010633 Cavia porcellus (guinea pig) RP48943 Caenorhabditis remanei (nematode) ENSCSAVP00000014825 Ciona savignyi (sedentary tunicate) ENSDARP00000088317 Danio rerio (zebra fish) ENSGACP00000011075 Gymnopilus aculeatus (mushroom) ENSGALP00000002095 Gallus gallus (chicken) ENSP00000263620 Homo sapiens (human) ENSMODP00000007047 Monodelphis domestica (gray opossum) ENSMMUP00000027359 Macaca mulatta (rhesus monkey) ENSMUSP00000019708 Mus musculus (house mouse) XP_001600051.1 Nasonia vitripennis (wasp) ENSORLP00000010296 Oryzias latipes (japanese killifish) LOC_Os06g41730.1 Oryza sativa (asian rice) ENSPPYP00000010436 Pongo pygmaeus (orangutan) ENSRNOP00000039046 Rattus norvegicus (norway rat) 57024 Trichoplax adhaerens (metazoa) ENSTNIP00000009503 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000043756 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000057283 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /polycomb/deadrnr1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45976 modMine - Data generated by the modENCODE project. • FBgn0004795 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0231925 FBgn0225027 FBgn0207134 FBgn0193644 FBgn0183519 FBgn0248832 FBgn0078855 FBgn0162841 FBgn0162770 FBgn0154478 FBgn0144475 FBgn0141766 FBgn0141447 FBgn0140433 FBgn0137713 FBgn0128127 FBgn0115029 FBgn0090102 REDfly - A database of transcriptional regulatory elements. • FBgn0004795
Synonyms & Secondary IDs ( 16 )
Reported As
Symbol Synonym	2535 (Harvie et al., 1998) BcDNA:LD35748   CG5403 (Perkins et al., 2009.3.31, Qin et al., 2005, Keleman et al., 2009.8.5, Berger et al., 2008, Ni et al., 2011.7.19) Dead Ringer/Retain (Yuasa and Hiromi, 2005) dri (Chandrasekaran and Beckendorf, 2005, Schnorrer and Dickson, 2004, Kortschak et al., 2000, Luschnig et al., 2004, Johansen et al., 2003, Freeman et al., 2003, Haberman et al., 2003, Abrams et al., 2003, Michaut et al., 2003, Shandala et al., 2003, Shandala et al., 2003, Johansen et al., 2003, Iwaki and Lengyel, 2002, Lengyel and Iwaki, 2002, Berger et al., 2001, Bradley et al., 2001, Nepveu, 2001, Sibbons et al., 2001, Ditch et al., 2001, Riechmann et al., 2000, Chen and Courey, 2000, Andrew et al., 2000, Hader et al., 2000, Iwahara and Clubb, 1999, Shandala et al., 1999, Mannervik et al., 1999, Valentine et al., 1998, Gerisch and Korge, 1997, Treisman et al., 1997, Gregory et al., 1996, Gregory et al., 1995, Berger et al., 2008, Shandala et al., 2002) Dri (Stathopoulos and Levine, 2004, Stathopoulos and Levine, 2002, Iwaki et al., 2001, Dallas et al., 2000) DRI (Yuasa and Hiromi, 2004, Iwahara et al., 2002, Bradley and Andrew, 2001, Yuasa and Hiromi, 2007) EY2-10 (Rebay et al., 2000) l(2)02535 (Spradling et al., 1999, Gerisch and Korge, 1997, Beaton, 1997.12.27, Meister and Braun, 1995.10, BDGP Project Members, 1994-1999, ) retn (Ruaud et al., 2010, Sandmann et al., 2007, Christensen et al., 2008.12.28, Christensen et al., 2008.12.28, Christensen et al., 2008.12.28, Christensen et al., 2009.5.6, Qin et al., 2005, Shirangi et al., 2006, Shandala et al., 2002) retn/dri (Ditch et al., 2002) unnamed (Treisman and Rubin, 1996)
Name Synonym	dead ringer (Courey and Jia, 2001, Kortschak et al., 2000, Abrams et al., 2003, Bradley et al., 2001, Gregory, 1996.6.27, Gregory et al., 1995, Shandala et al., 2002) dead-ringer (Berger et al., 2008) Dead Ringer/Retain (Yuasa and Hiromi, 2007) retained (Ruaud et al., 2010, Qin et al., 2005, Shirangi et al., 2006, Shandala et al., 2002) Retained (Nie et al., 2009)
Secondary FlyBase IDs
	FBgn0010517 FBgn0014151 FBgn0063144
References ( 87 )
Generate a list of	All references relating to this gene ( 87 )
List References by type	Research paper  ( 36 ) Supplementary material  ( 2 ) Review  ( 12 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 16 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 4 ) Curated genome annotation  ( 2 ) Automatic genome annotation  ( 1 )
Recent research papers ( 2 )
	Quan et al., 2011, Nat. Biotechnol. 29(5): 449--452 Parallel on-chip gene synthesis and application to optimization of protein expression. [FBrf0213642] Ruaud et al., 2010, Development 137(1): 123--131 The Drosophila nuclear receptors DHR3 and betaFTZ-F1 control overlapping developmental responses in late embryos. [FBrf0209613] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...