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Gene Dmel\Su(H)

General Information
Symbol	Dmel\Su(H)	Species	D. melanogaster
Name	Suppressor of Hairless	Annotation symbol	CG3497
Feature type	protein_coding_gene	FlyBase ID	FBgn0004837
Gene Model Status	Current	Stock availability	16 publicly available
Also Known As	SuH, l(2)br7, l(2)35Bh, br7, dRBP-JK, BG:DS00929.10, CSL
Genomic Location
Chromosome (arm)	2L	Recombination map	2-50.5
Cytogenetic map	35B8-35B8	Sequence location	2L:15,039,496..15,043,335 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Suppressor of Hairless is referred to in FlyBase by the symbol Dmel\Su(H) (CG3497, FBgn0004837). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; protein binding; RNA polymerase II distal enhancer sequence-specific DNA binding; sequence-specific DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; DNA binding. There is experimental evidence that it is involved in the biological process: sensory organ precursor cell fate determination; crystal cell differentiation; imaginal disc-derived wing vein morphogenesis; wing disc dorsal/ventral pattern formation; Notch signaling pathway; negative regulation of transcription from RNA polymerase II promoter; long-term memory; positive regulation of S phase of mitotic cell cycle. 95 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; adult segment; imaginal precursor; portion of tissue; eo support cell; thoracic segment; sense organ; non-connected developing system; late extended germ band embryo. It has one annotated transcript and one annotated polypeptide. Protein features are: Beta-trefoil DNA-binding domain; Cell surface receptor IPT/TIG; Immunoglobulin E-set; Immunoglobulin-like fold; LAG1, DNA binding; p53-like transcription factor, DNA-binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval central nervous system, adult ovary. Gene sequence location is 2L:15039496..15043335.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Su(H): Suppressor of Hairless Homozygous lethal; hemizygotes die in the pupal stage, between head eversion and the beginning of eye pigmentation. Heterozygotes in the absence of H are wild type in phenotype. Suppresses H; Su(H)/+; H/+ have 7-10 more bristles that H/+ alone; besides affecting the bristle phenotype of H, all alleles tend to enhance its wing-vein phenotype of shortening L4 and L5. Su(H) is without effect on the lethal phenotype of homozygous H. One homozygous-lethal allele acts as a dominant enhancer of H. Most alleles are amorphic or hypomorphic; heterozygous deficiencies for the locus also suppress, and duplications enhance H (Nash, 1970). Enhanced genotypes have 10-15 fewer bristles and a far more extreme loss of microchaetae on the thorax than their unenhanced counterparts. The number of bristles in H/+ flies is inversely related to the dose of Su(H)+, with the number of bristles varying from fewer than ten with four doses to approximately 35 with one dose. Some combinations of hypomorphic alleles produce occasional escapers; survivors have distinctive phenotypes, which are described under entries for specific alleles. Su(H)3 A leaky allele; trans heterozygotes with Su(H)1 show 20% survival; almost viable with Su(H)7; semilethal with Su(H)2, Su(H)4, Su(H)6, and Su(H)8; lethal in combination with Su(H)16. Survivors have vestigial wings and halteres and eyes somewhat reduced and rough; bristles normal. Su(H)7 Homozygous lethal; in trans heterozygotes with other alleles produces rare escapers, which have an extreme mutant phenotype; wings and halteres similar to those of an extreme vestigial allele; eyes, although large, have rough glazed appearance and the flies are almost achaetous, having fewer than ten macrochaetae per fly; acrostichal hairs and other microchaetae reduced in number and disturbed in arrangement; tarsal claws also much reduced. Su(H)16 Homozygous lethal; acts as a dominant enhancer of H, with about the same effect as heterozygosity for a duplication for the locus.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 35B8-35B8   Limits computationally determined from genome sequence between P{EP}elBEP2039&P{PZ}osprJ571 and P{lacW}Su(H)k07904
Experimentally Determined Cytological Location
Cytogenetic map Notes References 35B8-35B9   (determined by in situ hybridisation)   (Ashburner et al., 1999) 35B8-35B9   (determined by in situ hybridisation)   (Spradling et al., 1999) 35B8-35B10   (determined by in situ hybridisation)   (Beaton and Laverty, 1998.3.6) 35B8-35B9   (determined by in situ hybridisation)   (Roch et al., 1998) 35B8-35B9     (BDGP Project Members, 1994-1999) 35B9-35B10   (determined by in situ hybridisation)   (Schweisguth and Posakony, 1992) 35B-35C   (determined by in situ hybridisation)   (Furukawa et al., 1991)
Experimentally Determined Recombination Data
Location	2-50.5   2-50.8 (Schweisguth and Posakony, 1992)
Left of (cM)
Right of (cM)	dyn-p25 l(2)35Be (Woodruff and Ashburner, 1979) l(2)35Bc (Ashburner, 1982)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Su(H) for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Su(H)-RA FBtr0080700  NM_057520   2943   594
Additional Transcript Data & Comments
Reported size (kB)	3.4 (northern blot) (Furukawa et al., 1991) 2.9 (northern blot) (Schweisguth and Posakony, 1992)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Su(H)-PA   FBpp0080261   66.9   594   7.02     NP_476868   AAF53434
Additional Polypeptide Data & Comments
Reported size (kDa)	594 (aa) (Schweisguth and Posakony, 1992) 550, 485 (aa); 62, 54 (kD predicted) (Furukawa et al., 1991) 75-80 (kD observed) (Gho et al., 1996)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cell surface receptor IPT/TIG (IPR002909) p53-like transcription factor, DNA-binding (IPR008967) Immunoglobulin-like fold (IPR013783) Immunoglobulin E-set (IPR014756) Beta-trefoil DNA-binding domain (IPR015350) LAG1, DNA binding (IPR015351)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA539138   AA736032   AA817421   AA820823   AE014134 AAF53434   AC092238   AE003411 AAF44914   AF088255 AAD39698   AF088256 AAD39699   AF088257 AAD39700   AF088258 AAD39701   AF088259 AAD39702   AF088260 AAD39703   AF088261 AAD39704   AF088262 AAD39705   AF088263 AAD39706   AF088264 AAD39707   AF088265 AAD39708   AF088266 AAD39709   AF088267 AAD39710   AF088268 AAD39711   AF088269 AAD39712   AF088270 AAD39713   AF088271 AAD39714   AF088272 AAD39715   AF088273 AAD39716   AF088274 AAD39717   AI114192   AI257221   AQ025847   AW940393   AX482635   AY069091 AAL39236   BG635811   BI231099   BI366177   BI369056   BI485719   CL525941   CO189394   CO285290   CO287440   CO298621   CO307893   CO313496   CO319315   CO326191   CO343004   EC066892   EC068168   EC068370   EC079751   EC083127   EC198395   EC206779   EC214973   EC235912   EC257304   EC259000   L26094   L26095   L26096   L26097   M94383 AAA28919   S69213 AAA06211   X58393 CAA41282   Z50244   Z50648
UniProtKB/Swiss-Prot	P28159
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References regulatory region FBsf0000435518 2L:15,039,093..15,039,547 evidence=Reporter construct (in vivo) (Barolo et al., 2000, Halfon, 2012.6.19) regulatory region FBsf0000435720 2L:15,050,611..15,057,557 evidence=Rescue construct (Schweisguth and Posakony, 1992, Halfon, 2012.6.19) regulatory region FBsf0000436128 2L:15,043,399..15,043,769 evidence=Reporter construct (in vivo) (Barolo et al., 2000, Halfon, 2012.6.19) regulatory region FBsf0000436401 2L:15,043,769..15,045,269 evidence=Reporter construct (in vivo) (Barolo et al., 2000, Halfon, 2012.6.19)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early     (Schweisguth and Posakony, 1992) embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   central brain anlage in statu nascendi   (Fisher et al., 2012) dorsal ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi dorsal head epidermis anlage in statu nascendi   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage in statu nascendi hindgut anlage in statu nascendi   (Fisher et al., 2012) organism | segmentally repeated   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi antennal anlage in statu nascendi   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage in statu nascendi visual anlage in statu nascendi   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage in statu nascendi embryonic stage 7 -- 8   hindgut anlage   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   inclusive hindgut primordium   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   cardiogenic mesoderm   (Fisher et al., 2012) central brain primordium   (Fisher et al., 2012) dorsal sensory complex primordium   (Fisher et al., 2012) embryonic neuroblast of ventral nerve cord primordium   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) lateral cord   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) proventriculus primordium   (Fisher et al., 2012) somatic muscle primordium   (Fisher et al., 2012) ventral imaginal precursor   (Fisher et al., 2012) Comment:reported as ventral imaginal precursor specific anlage ventral nerve cord primordium   (Fisher et al., 2012) ventral sensory complex anlage   (Fisher et al., 2012) embryonic stage 11 -- 17   tormogen cell   (Schweisguth and Posakony, 1992) trichogen cell   (Schweisguth and Posakony, 1992) external sensory organ   (Schweisguth and Posakony, 1992) embryonic stage 13 -- 16   dorsal sensory complex proper primordium   (Fisher et al., 2012) Comment:reported as dorsal/lateral sensory complexes embryonic brain   (Fisher et al., 2012) embryonic head epidermis   (Fisher et al., 2012) embryonic head sensory system   (Fisher et al., 2012) embryonic ventral epidermis   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) sensory nervous system primordium   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) ventral sensory complex primordium   (Fisher et al., 2012) third instar larval stage   ventral thoracic disc   (Schweisguth and Posakony, 1992) eye-antennal disc   (Schweisguth and Posakony, 1992) wing disc   (Schweisguth and Posakony, 1992) pupal stage P5(ii) -- pupal stage P6   adult muscle precursor cell   (Schweisguth and Posakony, 1992) Comment:reference states 16-24 hr APF epidermis   (Schweisguth and Posakony, 1992) Comment:reference states 16-24 hr APF macrochaeta   (Miller et al., 2009) Comment:assayed at 17h, 21h, 30h APF microchaeta   (Miller et al., 2009) Comment:assayed at 17h, 21h, 30h APF tormogen cell   (Miller et al., 2009) Comment:assayed at 17h, 21h, 30h APF pupal stage P6   tormogen cell   (Schweisguth and Posakony, 1992) Comment:reference states 24 hr APF trichogen cell   (Schweisguth and Posakony, 1992) Comment:reference states 24 hr APF northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Furukawa et al., 1991) embryonic stage -- adult stage     (Furukawa et al., 1992) adult stage | female     (Furukawa et al., 1991) adult stage | male     (Furukawa et al., 1991)
Additional Descriptive Data
	Su(H) transcripts are present throughout the syncytial embryo. During cellularization, the rapid disappearance of putative maternal transcripts reveals a transient striped pattern. Transcripts are next observed from stage 11 on in external sensory organs. In the thoracic and abdominal segments the es cells were identified as the tormogen and trichogen. In late third instar larvae, expression is observed in many larval and imaginal tissues but not in the CNS. Transcripts are broadly distributed in the discs but in a nonuniform pattern. In the wing disc, transcripts are most abundant in the posterior region of the wing pouch. In the leg disc, expression is also observed in a posterior zone of the disc. In the eye-antennal disc, low levels of expression are observed posterior to the morphogenetic furrow and and in the central antennal region while higher levels are observed in the vicinity of the furrow and along the margins of the disc. In 16-24hr pupae, Su(H) is expressed in many tissues including developing muscle and epidermis. In michrochaetae and macrochaetae, expression is observed in a couple of large cells that appear to be the tormogen and trichogen. Expression in the tormogen occurs at a higher level. (Schweisguth and Posakony, 1992) Su(H) is stronglyly detected in all macrochaete socket cells 17, 21 and 30 hours APF. It is also observed in microchaetes at these stages. (Miller et al., 2009) Su(H) transcripts are detected in RNA from embryos, adult males and adult females. (Furukawa et al., 1991) Su(H)@ transcripts are detected throughout development by RNAase protection. (Furukawa et al., 1992)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference adult stage   adult brain | ubiquitous   (Song et al., 2009) western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage   external sensory organ   (Gho et al., 1996) presumptive embryonic/larval peripheral nervous system | restricted   (Gho et al., 1996)   (Gho et al., 1996) third instar larval stage   proneural cluster   (Gho et al., 1996) sensory mother cell   (Gho et al., 1996) wing disc   (Gho et al., 1996) pupal stage   external sensory organ precursor cell IIb   (Gho et al., 1996) external sensory organ precursor cell IIa   (Gho et al., 1996) socket   (Gho et al., 1996) socket of interommatidial bristle   (Gho et al., 1996)
Additional Descriptive Data
	Su(H) protein is observed in the nucleus in all cells in the third instar wing disc. It was sometimes observed in the surrounding cytoplasm of both macrochaete and microchaete SOPs. It is observed in the nucleus and cytoplasm of socket cells. It does not co-localize with N protein at the apicolateral membrane in socket cells. (Gho et al., 1996)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cytoplasm inferred from direct assay (Gho et al., 1996) nucleus inferred from direct assay (Gho et al., 1996) protein complex inferred from physical interaction with N (Kelly et al., 2007) transcriptional repressor complex inferred from genetic interaction with ebi (Tsuda et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval central nervous system, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    10 central nervous system, pupae P8    4 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    18 ovary, mated 4-day female    16 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    10 central nervous system, pupae P8    4 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    18 ovary, mated 4-day female    16 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    10 central nervous system, pupae P8    4 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    18 ovary, mated 4-day female    16 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    10 central nervous system, pupae P8    4 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    18 ovary, mated 4-day female    16 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    10 central nervous system, pupae P8    4 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    18 ovary, mated 4-day female    16 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    10 central nervous system, pupae P8    4 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    18 ovary, mated 4-day female    16 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    10 central nervous system, pupae P8    4 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    18 ovary, mated 4-day female    16 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    10 central nervous system, pupae P8    4 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    18 ovary, mated 4-day female    16 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    52 embryo 04-06hr    19 embryo 06-08hr    20 embryo 08-10hr    21 embryo 10-12hr    18 embryo 12-14hr    16 embryo 14-16hr    15 embryo 16-18hr    9 embryo 18-20hr    5 embryo 20-22hr    10 embryo 22-24hr    9 larva L1    4 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    8 white prepupae 24hr    14 pupae 2d postWPP    8 pupae 3d postWPP    5 pupae 4d postWPP    5 adult male 01day    5 adult male 05day    6 adult male 30day    7 adult female 01day    9 adult female 05day    14 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (35) embryo 02-04hr  (52) embryo 04-06hr    19 embryo 06-08hr    20 embryo 08-10hr    21 embryo 10-12hr    18 embryo 12-14hr    16 embryo 14-16hr    15 embryo 16-18hr    9 embryo 18-20hr    5 embryo 20-22hr    10 embryo 22-24hr    9 larva L1    4 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    8 white prepupae 24hr    14 pupae 2d postWPP    8 pupae 3d postWPP    5 pupae 4d postWPP    5 adult male 01day    5 adult male 05day    6 adult male 30day    7 adult female 01day    9 adult female 05day    14 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    52 embryo 04-06hr    19 embryo 06-08hr    20 embryo 08-10hr    21 embryo 10-12hr    18 embryo 12-14hr    16 embryo 14-16hr    15 embryo 16-18hr    9 embryo 18-20hr    5 embryo 20-22hr    10 embryo 22-24hr    9 larva L1    4 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    8 white prepupae 24hr    14 pupae 2d postWPP    8 pupae 3d postWPP    5 pupae 4d postWPP    5 adult male 01day    5 adult male 05day    6 adult male 30day    7 adult female 01day    9 adult female 05day    14 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    52 embryo 04-06hr    19 embryo 06-08hr    20 embryo 08-10hr    21 embryo 10-12hr    18 embryo 12-14hr    16 embryo 14-16hr    15 embryo 16-18hr    9 embryo 18-20hr    5 embryo 20-22hr    10 embryo 22-24hr    9 larva L1    4 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    8 white prepupae 24hr    14 pupae 2d postWPP    8 pupae 3d postWPP    5 pupae 4d postWPP    5 adult male 01day    5 adult male 05day    6 adult male 30day    7 adult female 01day    9 adult female 05day    14 adult female 30day    14 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    52 embryo 04-06hr    19 embryo 06-08hr    20 embryo 08-10hr    21 embryo 10-12hr    18 embryo 12-14hr    16 embryo 14-16hr    15 embryo 16-18hr    9 embryo 18-20hr    5 embryo 20-22hr    10 embryo 22-24hr    9 larva L1    4 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    8 white prepupae 24hr    14 pupae 2d postWPP    8 pupae 3d postWPP    5 pupae 4d postWPP    5 adult male 01day    5 adult male 05day    6 adult male 30day    7 adult female 01day    9 adult female 05day    14 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (35) embryo 02-04hr  (52) embryo 04-06hr    19 embryo 06-08hr    20 embryo 08-10hr    21 embryo 10-12hr    18 embryo 12-14hr    16 embryo 14-16hr    15 embryo 16-18hr    9 embryo 18-20hr    5 embryo 20-22hr    10 embryo 22-24hr    9 larva L1    4 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    8 white prepupae 24hr    14 pupae 2d postWPP    8 pupae 3d postWPP    5 pupae 4d postWPP    5 adult male 01day    5 adult male 05day    6 adult male 30day    7 adult female 01day    9 adult female 05day    14 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    52 embryo 04-06hr    19 embryo 06-08hr    20 embryo 08-10hr    21 embryo 10-12hr    18 embryo 12-14hr    16 embryo 14-16hr    15 embryo 16-18hr    9 embryo 18-20hr    5 embryo 20-22hr    10 embryo 22-24hr    9 larva L1    4 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    8 white prepupae 24hr    14 pupae 2d postWPP    8 pupae 3d postWPP    5 pupae 4d postWPP    5 adult male 01day    5 adult male 05day    6 adult male 30day    7 adult female 01day    9 adult female 05day    14 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    52 embryo 04-06hr    19 embryo 06-08hr    20 embryo 08-10hr    21 embryo 10-12hr    18 embryo 12-14hr    16 embryo 14-16hr    15 embryo 16-18hr    9 embryo 18-20hr    5 embryo 20-22hr    10 embryo 22-24hr    9 larva L1    4 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    8 white prepupae 24hr    14 pupae 2d postWPP    8 pupae 3d postWPP    5 pupae 4d postWPP    5 adult male 01day    5 adult male 05day    6 adult male 30day    7 adult female 01day    9 adult female 05day    14 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    5 embryonic 1182-4H    4 embryonic GM2    5 embryonic Kc167    6 embryonic S1    8 embryonic S3    3 leg disc CME L1    6 wing disc CME-W2    5 wing disc ML-DmD8    4 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    5 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    6 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    5 ovary fGS/OSS    6 ovary OSC    5 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    5 embryonic 1182-4H    4 embryonic GM2    5 embryonic Kc167    6 embryonic S1    8 embryonic S3    3 leg disc CME L1    6 wing disc CME-W2    5 wing disc ML-DmD8    4 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    5 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    6 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    5 ovary fGS/OSS    6 ovary OSC    5 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    5 embryonic 1182-4H    4 embryonic GM2    5 embryonic Kc167    6 embryonic S1    8 embryonic S3    3 leg disc CME L1    6 wing disc CME-W2    5 wing disc ML-DmD8    4 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    5 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    6 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    5 ovary fGS/OSS    6 ovary OSC    5 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    5 embryonic 1182-4H    4 embryonic GM2    5 embryonic Kc167    6 embryonic S1    8 embryonic S3    3 leg disc CME L1    6 wing disc CME-W2    5 wing disc ML-DmD8    4 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    5 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    6 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    5 ovary fGS/OSS    6 ovary OSC    5 ovary OSS    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    5 embryonic 1182-4H    4 embryonic GM2    5 embryonic Kc167    6 embryonic S1    8 embryonic S3    3 leg disc CME L1    6 wing disc CME-W2    5 wing disc ML-DmD8    4 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    5 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    6 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    5 ovary fGS/OSS    6 ovary OSC    5 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    5 embryonic 1182-4H    4 embryonic GM2    5 embryonic Kc167    6 embryonic S1    8 embryonic S3    3 leg disc CME L1    6 wing disc CME-W2    5 wing disc ML-DmD8    4 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    5 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    6 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    5 ovary fGS/OSS    6 ovary OSC    5 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    5 embryonic 1182-4H    4 embryonic GM2    5 embryonic Kc167    6 embryonic S1    8 embryonic S3    3 leg disc CME L1    6 wing disc CME-W2    5 wing disc ML-DmD8    4 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    5 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    6 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    5 ovary fGS/OSS    6 ovary OSC    5 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    5 embryonic 1182-4H    4 embryonic GM2    5 embryonic Kc167    6 embryonic S1    8 embryonic S3    3 leg disc CME L1    6 wing disc CME-W2    5 wing disc ML-DmD8    4 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    5 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    6 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    5 ovary fGS/OSS    6 ovary OSC    5 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    4 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    4 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    4 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    4 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    4 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    4 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    4 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    4 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_01 mE1_20_mRNA_expression_cluster_05
External Data & Images
Linkouts	BDGP expression data • GH10914 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004837 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3497-RB;CG3497-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Su(H) Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Su(H)IB115 lethal (with Su(H)1) Su(H)EG37 lethal (with Su(H)EG37) Su(H)1 lethal | larval stage | recessive Su(H)8 lethal | neurogenic phenotype | rescuable maternal effect Su(H)2 Su(H)8 lethal | pupal stage | recessive Su(H)1 Su(H)2 Su(H)6 Su(H)8 Su(H)IB115 Su(H)k07904 lethal | recessive Su(H)1 Su(H)2 Su(H)6 Su(H)7 Su(H)8 Su(H)9 Su(H)11 Su(H)16 Su(H)EG37 Su(H)k07904 Su(H)M28 Su(H)P183 Su(H)sA21 Su(H)sK2 Su(H)sO10 partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 Su(H)GD1544 viable Su(H)EY07695 Sterility Allele fertile Su(H)EY07695 Other Phenotypes Allele hyperplasia | adult stage, with Scer\GAL4GMR.PF Su(H)Scer\UAS.cMa Su(H)WARE.Scer\UAS hyperplasia | third instar larval stage, with Scer\GAL4bi-omb-Gal4 Su(H)Scer\UAS.cMa Su(H)WARE.Scer\UAS memory defective | adult stage Su(H)hs.PS memory defective | adult stage | dominant Su(H)8 Su(H)IB115 mitotic cell cycle defective Su(H)8 mitotic cell cycle defective | cell autonomous | somatic clone Su(H)del47 neuroanatomy defective Su(H)dsRNA.cIa neuroanatomy defective | embryonic stage 13, with Scer\GAL4sim.P3.7 Su(H)Scer\UAS.T:Hsap\MYC,T:Hsim\VP16 neuroanatomy defective | embryonic stage 16, with Scer\GAL4sim.P3.7 Su(H)Scer\UAS.T:Hsap\MYC,T:Hsim\VP16 visible Su(H)16 Su(H)+t6.0 Su(H)RC-9Xm visible, with Scer\GAL4bi-md653 Su(H)Scer\UAS.cNa visible, with Scer\GAL4Eq1 Su(H)Scer\UAS.T:Hsap\MYC visible, with Scer\GAL4pnr-MD237 Su(H)miRNA.Scer\UAS visible | adult stage, with Scer\GAL4GMR.PF Su(H)Scer\UAS.cMa Su(H)WARE.Scer\UAS visible | recessive Su(H)8 Su(H)12 Su(H)del47 Su(H)k07904 visible | recessive | somatic clone Su(H)2 Su(H)16 Su(H)T4 wild-type Su(H)+t6.0 Su(H)F Su(H)RC-9Xm Su(H)RC-ΔASE Phenotype manifest in Allele A1-7 dorsal acute muscle 1, with Scer\GAL4eve.eme Su(H)Scer\UAS.T:Hsim\VP16 adult midgut Su(H)del47 adult midgut epithelium | somatic clone Su(H)del47 adult thorax, with Scer\GAL4pnr-MD237 Su(H)miRNA.Scer\UAS anterior crossvein, with Scer\GAL4ptc-559.1 Su(H)Scer\UAS.cKa central nervous system | germline clone Su(H)2 Su(H)8 chaeta, with Scer\GAL4Eq1 Su(H)Scer\UAS.T:Hsap\MYC chaeta, with Scer\GAL4pnr-MD237 Su(H)miRNA.Scer\UAS crystal cell | larval stage (with Su(H)6) Su(H)8 crystal cell | larval stage (with Su(H)8) Su(H)6 dMP2 neuron | ectopic | germline clone Su(H)8 dorsal double row Su(H)2 dorsal mesothoracic disc & neuron Su(H)del47 egg chamber | somatic clone Su(H)del47 embryonic/first instar larval cuticle & embryonic head | germ-line clone Su(H)2 Su(H)8 embryonic/first instar larval cuticle | germline clone | ventral Su(H)2 Su(H)8 embryonic/larval lymph gland (with Su(H)1) Su(H)IB115 embryonic/larval lymph gland (with Su(H)IB115) Su(H)1 embryonic/larval lymph gland | larval stage (with Su(H)6) Su(H)8 embryonic/larval lymph gland | larval stage (with Su(H)8) Su(H)6 embryonic/larval somatic muscle Su(H)8 embryonic/larval somatic muscle | germline clone Su(H)8 embryonic epidermis Su(H)8 embryonic hindgut, with Scer\GAL4455.2 Su(H)Scer\UAS.T:Hsim\VP16 embryonic hindgut, with Scer\GAL4byn-Gal4 Su(H)Scer\UAS.T:Hsim\VP16 embryonic large intestine, with Scer\GAL4byn-Gal4 Su(H)Scer\UAS.T:Hsim\VP16 embryonic proventriculus Su(H)2 eye Su(H)12 Su(H)3 Su(H)7 Su(H)del47 eye, with Scer\GAL4GMR.PF Su(H)Scer\UAS.cMa Su(H)WARE.Scer\UAS eye | somatic clone Su(H)unspecified eye-antennal disc Su(H)1 Su(H)2 Su(H)8 Su(H)IB115 Su(H)P183 eye disc, with Scer\GAL4GMR.PF Su(H)Scer\UAS.T:Hsim\VP16 eye disc & neuron | somatic clone | cell autonomous Su(H)8 eye disc | cell autonomous | somatic clone Su(H)del47 eye disc | somatic clone Su(H)del47 femur | distal | somatic clone Su(H)2 follicle cell | somatic clone Su(H)8 Su(H)del47 follicle stem cell | somatic clone, with Scer\GAL4Act.PU, Scer\GAL4e22c, Scer\GAL4tub.PU Su(H)Scer\UAS.cSa.T:Hsim\VP16 follicle stem cell | somatic clone, with Scer\GAL4tub.PU Su(H)Scer\UAS.cSa.T:Hsim\VP16 germarium region 1 | somatic clone Su(H)del47 germinal vesicle | somatic clone Su(H)del47 haltere Su(H)3 Su(H)7 imaginal disc Su(H)k07904 intestinal stem cell | somatic clone | supernumerary Su(H)del47 joint | somatic clone Su(H)2 keyhole structure Su(H)2 larval outer optic anlage | somatic clone Su(H)del47 leg | anterior compartment Su(H)2 macrochaeta Su(H)+t6.0 Su(H)2 Su(H)6 Su(H)7 Su(H)RC-9Xm Su(H)hs.PS Su(H)hs.PS.8 macrochaeta, with Scer\GAL4Bx-MS1096 Su(H)Scer\UAS.cMa macrochaeta & adult abdomen Su(H)hs.1.T:Hsap\MYC macrochaeta & leg Su(H)hs.1.T:Hsap\MYC macrochaeta | somatic clone Su(H)16 Su(H)8 Su(H)T4 mesothoracic dorsal acute muscle 1, with Scer\GAL4eve.eme Su(H)Scer\UAS.T:Hsim\VP16 mesothoracic tergum & sensory organ cell & pupa | somatic clone Su(H)16 Su(H)T4 mesothoracic tergum | medial, with Scer\GAL4pnr-MD237 Su(H)Scer\UAS.cKa metathoracic dorsal acute muscle 1, with Scer\GAL4eve.eme Su(H)Scer\UAS.T:Hsim\VP16 microchaeta Su(H)hs.1.T:Hsap\MYC Su(H)hs.PS microchaeta, with Scer\GAL4Bx-MS1096 Su(H)Scer\UAS.cMa microchaeta | somatic clone Su(H)8 midline glial cell | embryonic stage 13 | supernumerary, with Scer\GAL4sim.P3.7 Su(H)Scer\UAS.T:Hsap\MYC,T:Hsim\VP16 midline glial cell | embryonic stage 16 | supernumerary, with Scer\GAL4sim.P3.7 Su(H)Scer\UAS.T:Hsap\MYC,T:Hsim\VP16 neuroblast | germline clone Su(H)2 Su(H)8 neuron & eye | somatic clone Su(H)del47 neuron & eye | supernumerary | somatic clone Su(H)del47 neuron | ectopic Su(H)8 ommatidium Su(H)12 Su(H)del47 pericardial cell, with Scer\GAL4eve.eme Su(H)Scer\UAS.T:Hsim\VP16 pericardial cell | ectopic, with Scer\GAL4eve.eme Su(H)Scer\UAS.T:Hsim\VP16 peripheral nervous system | germline clone Su(H)2 Su(H)8 photoreceptor cell Su(H)P183 photoreceptor cell & axon & larva Su(H)E86 photoreceptor cell R8 & eye disc | ectopic | somatic clone Su(H)del47 photoreceptor cell R8 & eye disc | somatic clone Su(H)del47 photoreceptor cell R8 | cell autonomous | ectopic | somatic clone Su(H)8 plasmatocyte (with Su(H)1) Su(H)IB115 plasmatocyte (with Su(H)IB115) Su(H)1 proneural cluster Su(H)2 Su(H)8 Su(H)del47 proneural cluster, with Scer\GAL4klu-G410 Su(H)Scer\UAS.cKa proneural cluster & dorsal mesothoracic disc Su(H)2 Su(H)8 proventriculus inner layer primordium Su(H)2 proventriculus intermediate layer primordium Su(H)2 proventriculus outer layer primordium Su(H)2 RP2 motor neuron | ectopic | germline clone Su(H)8 RP2sib neuron | germline clone Su(H)8 sensory mother cell Su(H)1 Su(H)2 Su(H)8 Su(H)IB115 Su(H)del47 Su(H)hs.2.T:Hsap\MYC sensory mother cell | ectopic Su(H)2 sensory organ cell | P-stage | somatic clone Su(H)16 Su(H)T4 socket Su(H)+t6.0 tibia | proximal | somatic clone Su(H)2 tormogen cell Su(H)6 tormogen cell | ectopic Su(H)+t6.0 Su(H)RC-9Xm tormogen cell | somatic clone Su(H)8 trichogen cell Su(H)hs.PS.8 type II neuroblast | somatic clone Su(H)del47 U neuron | ectopic | germline clone Su(H)8 unguis Su(H)7 Usib neuron | germline clone Su(H)8 ventral double row Su(H)2 visceral mesoderm, with Scer\GAL4how-24B Su(H)Scer\UAS.T:Hsap\MYC,T:Hsim\VP16 vMP2 neuron | ectopic | germline clone Su(H)8 wing Su(H)1 Su(H)16 Su(H)2 Su(H)3 Su(H)7 Su(H)8 Su(H)k07904 Su(H)WRPW.Scer\UAS wing, with Scer\GAL4bi-md653 Su(H)Scer\UAS.cNa wing, with Scer\GAL4dpp.blk1 Su(H)Scer\UAS.T:Hsim\VP16 Su(H)Scer\UAS.T:SV40\nls2 wing, with Scer\GAL4ptc-559.1 Su(H)Scer\UAS.T:Hsim\VP16 Su(H)Scer\UAS.T:SV40\nls2 Su(H)Scer\UAS.cNa wing (with Su(H)2) Su(H)8 wing (with Su(H)8) Su(H)2 wing | proximal, with Scer\GAL4dpp.blk1 Su(H)Scer\UAS.T:SV40\nls2 wing | proximal, with Scer\GAL4ptc-559.1 Su(H)Scer\UAS.cKa wing disc Su(H)1 Su(H)2 Su(H)8 Su(H)IB115 wing disc, with Scer\GAL4ap-md544 Su(H)Scer\UAS.cNa wing disc, with Scer\GAL4Bx-MS1096 Su(H)Scer\UAS.cNa wing disc, with Scer\GAL4ptc-559.1 Su(H)Scer\UAS.T:SV40\nls2 Su(H)Scer\UAS.cKa wing disc | third instar larval stage, with Scer\GAL4bi-omb-Gal4 Su(H)Scer\UAS.cMa Su(H)WARE.Scer\UAS wing margin, with Scer\GAL4bi-md653 Su(H)WRPW.Scer\UAS wing margin, with Scer\GAL4dpp.blk1 Su(H)Scer\UAS.T:Hsap\MYC,T:Hsim\VP16 wing margin | distal, with Scer\GAL4ptc-559.1 Su(H)ΔH.Scer\UAS Su(H)Scer\UAS.T:SV40\nls2 wing margin | ectopic, with Scer\GAL4dpp.blk1 Su(H)Scer\UAS.T:Hsim\VP16 wing margin | ectopic, with Scer\GAL4ptc-559.1 Su(H)Scer\UAS.T:Hsim\VP16 wing margin bristle, with Scer\GAL4klu-G410 Su(H)Scer\UAS.cKa wing vein Su(H)2 Su(H)k07904 wing vein, with Scer\GAL4bi-md653 Su(H)Scer\UAS.cNa wing vein, with Scer\GAL4en-e16E Su(H)Scer\UAS.cNa wing vein L3 Su(H)2 wing vein L3, with Scer\GAL4dpp.blk1 Su(H)Scer\UAS.T:Hsim\VP16 Su(H)Scer\UAS.T:SV40\nls2 Su(H)Scer\UAS.cKa wing vein L3, with Scer\GAL4ptc-559.1 Su(H)ΔH.Scer\UAS
Classical Alleles ( 59 )
For All Classical Alleles Show
Allele of Su(H) Class Mutagen Stocks Known lesion Su(H)1 loss of function allele, amorphic allele - genetic evidence spontaneous ethyl methanesulfonate 5 -- Su(H)2 loss of function allele, amorphic allele - genetic evidence spontaneous natural population 2 Yes Su(H)k07904 P-element activity 2 -- Su(H)8 loss of function allele, amorphic allele - genetic evidence, hypomorphic allele - genetic evidence triethylenemelamine 1 -- Su(H)IB115 loss of function allele, amorphic allele - genetic evidence ethyl methanesulfonate 1 Yes Su(H)EY07695 P-element activity 1 -- Su(H)M28 P-element activity PM hybrid dysgenesis 1 -- Su(H)05 0 -- Su(H)10 ethyl methanesulfonate 0 -- Su(H)11 ethyl methanesulfonate 0 -- Su(H)12 hypomorphic allele - genetic evidence PM hybrid dysgenesis P-element activity 0 Yes Su(H)13 hypomorphic allele - genetic evidence PM hybrid dysgenesis P-element activity 0 Yes Su(H)14 hypomorphic allele - genetic evidence PM hybrid dysgenesis P-element activity 0 Yes Su(H)15 PM hybrid dysgenesis 0 -- Su(H)16 hypermorphic allele - genetic evidence, gain of function allele ethyl methanesulfonate 0 Yes Su(H)226.1 gamma ray 0 -- Su(H)3 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- Su(H)4 ethyl methanesulfonate 0 -- Su(H)5 ethyl methanesulfonate 0 -- Su(H)6 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes Su(H)7 ethyl methanesulfonate 0 -- Su(H)8B1 ethyl nitrosourea 0 -- Su(H)9 ethyl methanesulfonate 0 -- Su(H)AM1 ethyl methanesulfonate 0 -- Su(H)del47 P-element activity 0 Yes Su(H)E(H) gain of function allele 0 -- Su(H)E86 ethyl methanesulfonate 0 -- Su(H)eBC11 gain of function allele ethyl methanesulfonate 0 Yes Su(H)EG37 ethyl methanesulfonate 0 -- Su(H)hs.PS.8 Delta2-3 0 Yes Su(H)In-L101 natural population 0 -- Su(H)In-L12 natural population 0 -- Su(H)In-L14 natural population 0 -- Su(H)In-L18 natural population 0 -- Su(H)In-L19 natural population 0 -- Su(H)In-L21 natural population 0 -- Su(H)In-L31 natural population 0 -- Su(H)In-L3 natural population 0 -- Su(H)In-L4 natural population 0 -- Su(H)O5 gain of function allele ethyl methanesulfonate 0 Yes Su(H)P183 ethyl methanesulfonate 0 -- Su(H)rv1 Delta2-3 0 Yes Su(H)rv2 Delta2-3 0 Yes Su(H)sA21 ethyl methanesulfonate 0 -- Su(H)sK2 ethyl methanesulfonate 0 -- Su(H)sO10 ethyl methanesulfonate 0 -- Su(H)St-L106 natural population 0 -- Su(H)St-L111 natural population 0 -- Su(H)St-L120 natural population 0 -- Su(H)St-L124 natural population 0 -- Su(H)St-L127 natural population 0 -- Su(H)St-L13 natural population 0 -- Su(H)St-L26 natural population 0 -- Su(H)St-L27 natural population 0 -- Su(H)St-L28 natural population 0 -- Su(H)St-L5 natural population 0 -- Su(H)St-L7 natural population 0 -- Su(H)T4 gain of function allele ethyl methanesulfonate 0 Yes Su(H)unspecified 0 --
Alleles Carried on Transgenic Constructs ( 36 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Su(H) Class Mutagen Stocks Known lesion Su(H)HM05110 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Su(H)KK101550 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Su(H)Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 1 Yes Su(H)+t6.0 gain of function allele in vitro construct - genomic fragment 0 Yes Su(H)Act5C.PB in vitro construct - regulatory fusion 0 Yes Su(H)Act5C.PW in vitro construct - regulatory fusion 0 Yes Su(H)dsRNA.cHa in vitro construct - RNAi 0 Yes Su(H)dsRNA.cIa in vitro construct - RNAi 0 Yes Su(H)dsRNA.cWa in vitro construct - RNAi 0 Yes Su(H)dsRNA.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Su(H)F in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes Su(H)GD1544 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Su(H)hs.1.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Su(H)hs.2.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Su(H)hs.PS in vitro construct - regulatory fusion 0 Yes Su(H)hs.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct 0 Yes Su(H)miRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Su(H)MtnA.PA in vitro construct - regulatory fusion 0 Yes Su(H)MtnA.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Su(H)NIG.3497R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Su(H)RC-9Xm in vitro construct - site directed mutagenesis 0 Yes Su(H)RC-ΔASE in vitro construct - deletion 0 Yes Su(H)Scer\UAS.cGa in vitro construct - regulatory fusion 0 -- Su(H)Scer\UAS.cKa in vitro construct - regulatory fusion 0 Yes Su(H)Scer\UAS.cMa in vitro construct - regulatory fusion 0 Yes Su(H)Scer\UAS.cNa in vitro construct - regulatory fusion 0 Yes Su(H)Scer\UAS.cPa in vitro construct - regulatory fusion 0 Yes Su(H)Scer\UAS.cSa.T:Hsim\VP16 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Su(H)Scer\UAS.T:Hsap\MYC,T:Hsim\VP16 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Su(H)Scer\UAS.T:Hsim\VP16 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Su(H)Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Su(H)Scer\UAS.T:SV40\nls2 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Su(H)VDRC.cUa in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Su(H)WARE.Scer\UAS 0 -- Su(H)WRPW.Scer\UAS in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Su(H)ΔH.Scer\UAS in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)64j (Iyengar et al., 1999, O'Donnell et al., 1977, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979, Ashburner, 1982, Ashburner et al., 1990, Furukawa et al., 1992) Df(2L)A48 (Spradling et al., 1999, Ashburner et al., 1982, BDGP Project Members, 1994-1999, Ma et al., 2009, Grau et al., 1984) Df(2L)A72 (Ashburner et al., 1982, Ashburner et al., 1990) Df(2L)A215 (Ashburner et al., 1982) Df(2L)A220 (Ashburner et al., 1982, Roote, 1996.5.20) Df(2L)A246 (Ashburner et al., 1982) Df(2L)A263 (Ashburner et al., 1982, Furukawa et al., 1992) Df(2L)A264 (Ashburner et al., 1982) Df(2L)A267 (Ashburner et al., 1982, Ashburner et al., 1990) Df(2L)A376 (Ashburner et al., 1982, Ashburner, 1982) Df(2L)A377 (Ashburner et al., 1982, Ashburner, 1982) Df(2L)A400 (Ashburner et al., 1982, Ashburner, 1982) Df(2L)AntpCtxrv1 (Roote, 1996.8) Df(2L)ARR1 (Ashburner, 1982, Gubb et al., 1984, Ashburner et al., 1990, Furukawa et al., 1992, Roote, 1996.8) Df(2L)b80e4 (Ashburner et al., 1990) Df(2L)b84h50 (Spradling et al., 1999, Furukawa et al., 1992, BDGP Project Members, 1994-1999) Df(2L)b87e25 (Alexandrova et al., 1996) Df(2L)BSC299 (Christensen and Cook, 2007.5.8) Df(2L)do1 (Ashburner, 1982) Df(2L)el20 (Ashburner et al., 1990) Df(2L)el28 (Ashburner et al., 1990, Furukawa et al., 1992) Df(2L)el77 (Woodruff and Ashburner, 1979) Df(2L)Exel7061 (Ryder, 2004.4.26) Df(2L)fn1 (O'Donnell et al., 1977, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979, Ashburner et al., 1982, Grau et al., 1984) Df(2L)fn3 (Woodruff and Ashburner, 1979) Df(2L)fn5 (O'Donnell et al., 1977, Ashburner et al., 1982, Furukawa et al., 1992) Df(2L)fn7 (Woodruff and Ashburner, 1979) Df(2L)fn12 (O'Donnell et al., 1977, Woodruff and Ashburner, 1979, Ashburner et al., 1982, Ashburner et al., 1990) Df(2L)fn15 (O'Donnell et al., 1977, Ashburner et al., 1982) Df(2L)fn26 (O'Donnell et al., 1977, Ashburner et al., 1982, Ashburner et al., 1990) Df(2L)fn27 (O'Donnell et al., 1977, Ashburner et al., 1982, Ashburner, 1982, Ashburner et al., 1990) Df(2L)fn30 (O'Donnell et al., 1977, Ashburner et al., 1982) Df(2L)n78l3 (Ashburner et al., 1990) Df(2L)noc11 (Ashburner et al., 1990) Df(2L)osp29 (Furukawa et al., 1992, Grau et al., 1984) Df(2L)osp38 (Ashburner et al., 1990) Df(2L)Sco7 (Ashburner et al., 1990) Df(2L)Scorv4 (Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979) Df(2L)Scorv23 (Ashburner, 1982, Grau et al., 1984) Df(2L)TE35B-1 (Gubb et al., 1985) Df(2L)TE35B-2 (Gubb et al., 1985) Df(2L)TE35B-5 (Gubb et al., 1985) Df(2L)TE35B-6 (Gubb et al., 1985) Df(2L)TE35BC-1 (Ashburner et al., 1981, Ashburner, 1982, Gubb et al., 1984) Df(2L)TE35BC-4 (Ashburner, 1982, Gubb et al., 1984, Ashburner et al., 1990, Fortini and Artavanis-Tsakonas, 1994) Df(2L)TE35BC-6 (Gubb et al., 1984) Df(2L)TE35BC-7 (Gubb et al., 1984, Furukawa et al., 1992) Df(2L)TE35BC-8 (Gubb et al., 1984) Df(2L)TE35BC-23 (Gubb et al., 1984) Df(2L)TE35BC-24 (Iyengar et al., 1999, Gubb et al., 1984, Gho et al., 1996, Ma et al., 2009) Df(2L)TE35BC-28 (Gubb et al., 1984, Furukawa et al., 1992, Fortini and Artavanis-Tsakonas, 1994) Df(2L)TE35BC-29 (Gubb et al., 1984) Df(2L)TE35BC-31 (Gubb et al., 1984) Df(2L)TE35BC-34 (Gubb et al., 1984, Ashburner et al., 1990) Df(2L)TE35BC-35 (Gubb et al., 1984) Df(2L)TE35D-20 (Ashburner et al., 1990) Df(2L)TE35D-23 (Ashburner et al., 1990) Df(2L)W (Woodruff and Ashburner, 1979) In(2L)75c (Spradling et al., 1999, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979, Ashburner, 1982, Grau et al., 1984, BDGP Project Members, 1994-1999) In(2L)75cLC158.1R (Woodruff and Ashburner, 1979) In(2L)C158LScorv11R (Ashburner and Harrington, 1984) In(2L)C158LScorv17R (Ashburner and Harrington, 1984) In(2L)el18 (Ashburner et al., 1990) In(2L)TE35B-13 (Gubb et al., 1985) In(2LR)noc4LScorv9R (Ashburner and Harrington, 1984) In(2LR)TE35B-6LScorv9R (Ashburner and Harrington, 1984) T(Y;2)A80DR15P (Woodruff and Ashburner, 1979) Tp(2;2)A446 (Ashburner et al., 1982) Ts(2Lt;3Lt)TE35B-4+Ts(2Rt;3Rt)Scorv13 (Ashburner and Harrington, 1984) Ts(2Lt;3Lt)TE35BC-3+Ts(2Rt;3Rt)Scorv13 (Ashburner and Harrington, 1984) Ts(Y;2Lt)el4+Ts(YSt;2Rt)R15 (Roote, 1996.1.11, Roote, 1996.8)
Not disrupted in	Df(2L)A47 (Ashburner et al., 1982) Df(2L)A63 (Ashburner et al., 1982) Df(2L)A178 (Ashburner et al., 1982) Df(2L)A217 (Ashburner et al., 1982) Df(2L)A245 (Ashburner et al., 1982) Df(2L)A260 (Ashburner et al., 1982) Df(2L)A266 (Ashburner et al., 1982) Df(2L)A379 (Ashburner et al., 1982) Df(2L)A445 (Ashburner et al., 1982) Df(2L)b75 (Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979) Df(2L)b80k (Roote, 1996.8) Df(2L)b84a3 (Furukawa et al., 1992) Df(2L)b84a7 (Furukawa et al., 1992) Df(2L)el77 (Woodruff and Ashburner, 1979) Df(2L)fn2 (O'Donnell et al., 1977, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979, Ashburner et al., 1982, Grau et al., 1984) Df(2L)fn3 (O'Donnell et al., 1977, Woodruff and Ashburner, 1979, Ashburner et al., 1982, Ashburner, 1982) Df(2L)fn7 (O'Donnell et al., 1977, Woodruff and Ashburner, 1979, Ashburner et al., 1982, Ashburner, 1982) Df(2L)fn31 (O'Donnell et al., 1977, Ashburner et al., 1982, Ashburner, 1982) Df(2L)fn36 (O'Donnell et al., 1977, Ashburner et al., 1982) Df(2L)H20 (Ashburner et al., 1990) Df(2L)PZ07130-mr2 (Roote, 2000.6.13) Df(2L)PZ07130-mr3 (Roote, 2000.6.13) Df(2L)PZ07130-mr5 (Roote, 2000.6.13) Df(2L)PZ07130-mr7 (Roote, 2000.6.13) Df(2L)PZ07130-mr8 (Roote, 2000.6.13) Df(2L)r10 (Ashburner et al., 1990) Df(2L)RA5 (Ashburner et al., 1990) Df(2L)rd9 (Ashburner et al., 1990, Furukawa et al., 1992) Df(2L)RM5 (Ashburner et al., 1990) Df(2L)RN2 (Ashburner et al., 1990) Df(2L)Sco-1 (Ashburner, 1982) Df(2L)Scorv10 (Grau et al., 1984) Df(2L)Scorv16 (Ashburner et al., 1990, Grau et al., 1984) Df(2L)Scorv18 (Ashburner et al., 1990) Df(2L)Scorv19 (Ashburner et al., 1990, Grau et al., 1984) Df(2L)Scorv25 (Ashburner et al., 1990, Grau et al., 1984) Df(2L)SS1 (Ashburner et al., 1990, Grau et al., 1984) Df(2L)TE35B-3 (Gubb et al., 1985) Df(2L)TE35B-4 (Gubb et al., 1985) Df(2L)TE35B-7 (Gubb et al., 1985) Df(2L)TE35B-8 (Gubb et al., 1985) Df(2L)TE35B-9 (Gubb et al., 1985) Df(2L)TE35B-10 (Gubb et al., 1985) Df(2L)TE35B-11 (Gubb et al., 1985) Df(2L)TE35B-12 (Gubb et al., 1985) Df(2L)TE35B-15 (Gubb et al., 1985) Df(2L)TE35BC-3 (Ashburner, 1982, Gubb et al., 1984, Ashburner et al., 1990, Grau et al., 1984) Df(2L)TE35D-1 (Ashburner et al., 1990) Df(2L)TE35D-2 (Ashburner et al., 1990, Furukawa et al., 1992) Df(2L)TE35D-3 (Ashburner et al., 1990) Df(2L)TE35D-4 (Ashburner et al., 1990) Df(2L)TE35D-6 (Ashburner et al., 1990, Furukawa et al., 1992) Df(2L)TE35D-13 (Ashburner et al., 1990, Furukawa et al., 1992) Df(2L)TE35D-14 (Ashburner et al., 1990) Df(2L)TE35D-15 (Ashburner et al., 1990, Furukawa et al., 1992) Df(2L)TE35D-16 (Ashburner et al., 1990) Df(2L)TE35D-18 (Furukawa et al., 1992) Df(2L)TE35D-19 (Ashburner et al., 1990) Df(2L)TE35D-21 (Ashburner et al., 1990) Df(2L)TE35D-22 (Ashburner et al., 1990) Df(2L)W (Woodruff and Ashburner, 1979) In(2L)75cLC158.1R (Woodruff and Ashburner, 1979) In(2L)dpps22Ldppd36R (Ashburner et al., 1990) In(2LR)Scorv1-DV7 (Ashburner et al., 1990) T(2;3)Scorv7 (Ashburner et al., 1990, Grau et al., 1984, Woodruff and Ashburner, 1979) T(Y;2)J165DP58P (Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979) T(Y;2)R15DJ165P (Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)
Not duplicated in	Dp(2;2)Adh3 (Ashburner et al., 1982, Ashburner, 1982)
Duplicated in	Dp(2;1)Scorv23 (Ashburner, 1982, Ashburner et al., 1990, Grau et al., 1984) Dp(2;2)GYL (Ashburner, 1982, Ashburner et al., 1990) Dp(2;2)GYS (Ashburner, 1982) Dp(2;2)TE35B-54L (Ashburner et al., 1990, Gubb et al., 1997) Dp(2;3)osp3 (Ashburner et al., 1990) In(2L)C163.41LC158R (Ashburner, 1982, Ashburner et al., 1990) In(2L)C163.41LTE35B-210R (Gubb et al., 1997) In(2L)Scorv17LC158R (Ashburner, 1982, Ashburner et al., 1990) In(2LR)Scorv1LTE35B-15R (Gubb et al., 1997) Ts(2Lt;3Lt)G16+Ts(2Rt;3Rt)TE35B-3 (Gubb et al., 1997) Ts(2Lt;3Lt)G40+Ts(2Rt;3Rt)TE35B-28 (Gubb et al., 1997) Ts(2Lt;4Lt)DTD22+Ts(2Rt;4Rt)TE35B-50 (Gubb et al., 1997)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1544} NA P{KK101550} NA P{TRiP.HM05110} NA P{UAS-Su(H).dsRNA} NA P{UAS-Su(H).G} NA P{UAS-Su(H).K} NA P{UAS-Su(H).M} NA P{UAS-Su(H).miRNA} NA P{UAS-Su(H).myc} NA P{UAS-Su(H).N} NA P{UAS-Su(H).NLS} NA P{UAS-Su(H).P} NA P{UAS-Su(H).VP16.C} NA P{UAS-Su(H).VP16.S} NA P{UAS-Su(H).VP16} NA P{UAS-Su(H).WARE} NA P{UAS-Su(H).WRPW} NA P{UAS-Su(H).ΔH} NA reporter construct P{Su(H)-lacZ.5x} No P{Su(H)-lacZ.-403} No P{Su(H)-lacZ.-722} No P{Su(H)-lacZ.ASE5} No GAL4 construct P{Su(H)GBE-GAL4} No heat-shock construct P{hs-Su(H).F1} NA P{hs-Su(H).F2} NA P{Hs-Su(H)} NA characterization construct P{en::Su(H).FRT.T} NA P{en::Su(H).hs.2sev.T} NA P{Su(H)+6.0} NA P{Su(H)F} NA P{Su(H)RC-9Xm} NA P{Su(H)RC-ΔASE} NA P{Su(H)-GAL4.ASE5} NA P{Su(H)-GFP.ASE5} NA P{Su(H)-GFP.ASE.nls} NA P{Su(H)-GFP.ASE} NA P{Su(H)-GFP.ASEm.nuc} NA P{Su(H)-GFP.ASEm} NA P{VDRC.Su(H).U} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}l(2)SH0822SH0822 No P{lacW}Su(H)k07904 No insertion of mobile activating element P{EPgy2}Su(H)EY07695 NA miscellaneous insertions P{}Su(H)12 NA P{}Su(H)13 NA P{}Su(H)14 NA P{}Su(H)15 NA P{Hs-Su(H)}8 NA P{X6}Su(H)M28 NA
Gene Ontology: Function, Process & Cellular Component ( 28 unique terms )
Terms Based on Experimental Evidence ( 18 terms )
Molecular Function
CV term Evidence References
DNA binding inferred from direct assay (assigned by UniProtKB) (Morel and Schweisguth, 2000) protein binding inferred from physical interaction with ebi (Tsuda et al., 2006) inferred from physical interaction with N (Kelly et al., 2007) inferred from physical interaction with Smr (Tsuda et al., 2006) contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription inferred from genetic interaction with ebi (Tsuda et al., 2006) RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription inferred from direct assay (Lecourtois and Schweisguth, 1995) inferred from mutant phenotype (Tsuda et al., 2006) RNA polymerase II distal enhancer sequence-specific DNA binding inferred from direct assay (Miller et al., 2009) sequence-specific DNA binding inferred from direct assay (Tsuda et al., 2006)
Biological Process
CV term Evidence References
crystal cell differentiation inferred from mutant phenotype (Duvic et al., 2002) imaginal disc-derived wing vein morphogenesis inferred from mutant phenotype (Nagel et al., 2005) long-term memory inferred from mutant phenotype (Song et al., 2009) negative regulation of transcription from RNA polymerase II promoter inferred from genetic interaction with Sox15 (Miller et al., 2009) Notch signaling pathway inferred from genetic interaction with N (Fortini and Artavanis-Tsakonas, 1994) inferred from mutant phenotype (Wesley and Mok, 2003) inferred from mutant phenotype (assigned by UniProtKB) (Morel and Schweisguth, 2000) positive regulation of S phase of mitotic cell cycle inferred from mutant phenotype (Firth and Baker, 2005) sensory organ precursor cell fate determination inferred from mutant phenotype (Koelzer and Klein, 2003) inferred from mutant phenotype (assigned by UniProtKB) (Morel and Schweisguth, 2000) wing disc dorsal/ventral pattern formation inferred from genetic interaction with Psn (Koelzer and Klein, 2006)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Gho et al., 1996) nucleus inferred from direct assay (Gho et al., 1996) protein complex inferred from physical interaction with N (Kelly et al., 2007) transcriptional repressor complex inferred from genetic interaction with ebi (Tsuda et al., 2006)
Terms Based on Predictions or Assertions ( 13 terms )
Molecular Function
CV term Evidence References
DNA binding non-traceable author statement (Bardin et al., 2004) traceable author statement (Majumdar et al., 1997) RNA polymerase II core promoter proximal region sequence-specific DNA binding inferred from electronic annotation with InterPro:IPR015350 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
asymmetric cell division traceable author statement (Bardin et al., 2004) cell fate determination traceable author statement (Bardin et al., 2004) NOT dorsal/ventral lineage restriction, imaginal disc non-traceable author statement (McNeill, 2000) hemopoiesis traceable author statement (Evans et al., 2003) lateral inhibition traceable author statement (Martinez Arias, 2002) negative regulation of compound eye cone cell fate specification traceable author statement (Lai, 2002) negative regulation of transcription, DNA-dependent traceable author statement (Lai, 2002) Notch signaling pathway non-traceable author statement (Canon and Banerjee, 2000) traceable author statement (Majumdar et al., 1997, Kumar and Moses, 2000) positive regulation of transcription, DNA-dependent traceable author statement (Lai, 2002) positive regulation of transcription from RNA polymerase II promoter traceable author statement (Kumar and Moses, 2000, Lai et al., 2000)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity (Ashburner et al., 1999) traceable author statement (Majumdar et al., 1997)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Su(H) - Amun experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Su(H) - B52 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Su(H) - CG15220 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Su(H) - CG5746 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Su(H) - CG7911 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Su(H) - Chc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Su(H) - Clc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Su(H) - H two hybrid, anti tag coimmunoprecipitation, peptide massfingerprinting (Kurth et al., 2011, Maier et al., 2011, Mintseris et al., 2009.11.23) Su(H) - N two hybrid (Maier et al., 2011, Kurth et al., 2011) Su(H) - Rbp1-like anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Su(H) - SC35 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Su(H) - btz anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Su(H) - insv pull down, western blot (Duan et al., 2011) Su(H) - pasha anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Su(H) allele Gene References Su(H)2 E(spl)m7-HLH (Klein et al., 2000) E(spl)m8-HLH (Klein et al., 2000) fred (Chandra et al., 2003) N (Fortini and Artavanis-Tsakonas, 1994, Royet et al., 1998, Rollins et al., 1999) sno (Majumdar et al., 1997) vg (Klein and Martinez Arias, 1998) Su(H)6 H (Furukawa et al., 1992) Su(H)8 E(spl)m7-HLH (Klein et al., 2000) E(spl)m8-HLH (Klein et al., 2000) H (Schweisguth and Posakony, 1992) numb (Wang et al., 1997) Src42A (Zhang et al., 1999) Tom (Zaffran and Frasch, 2000) vg (Klein and Martinez Arias, 1998) Su(H)11 H (O'Donnell et al., 1977) Su(H)12 Dl (Jacobsen et al., 1998) H (Furukawa et al., 1992) Su(H)13 H (Furukawa et al., 1992) Su(H)14 H (Furukawa et al., 1992) Su(H)16 E(Egfr)B56 (Price et al., 1997) E(Egfr)C12 (Price et al., 1997) E(Egfr)C22 (Price et al., 1997) gro (Price et al., 1997) H (Price et al., 1997) mam (Fortini and Artavanis-Tsakonas, 1994, Helms et al., 1999) N (Fortini and Artavanis-Tsakonas, 1994, Rollins et al., 1999) vn (Price et al., 1997) Su(H)226.1 N (Rollins et al., 1999) Su(H)+t6.0 H (Schweisguth and Posakony, 1992) Su(H)del47 H (Morel and Schweisguth, 2000) Su(H)eBC11 H (Verheyen et al., 1996) N (Verheyen et al., 1996) Su(H)hs.PS N (Schweisguth et al., 1996) Su(H)IB115 N (Matsuno et al., 1997, Ramain et al., 2001) Su(H)O5 H (Fortini and Artavanis-Tsakonas, 1994) mam (Fortini and Artavanis-Tsakonas, 1994) N (Fortini and Artavanis-Tsakonas, 1994) Su(H)RC-9Xm CtBP (Barolo et al., 2002) gro (Barolo et al., 2002) Su(H)sA21 H (Verheyen et al., 1996) N (Verheyen et al., 1996) Su(H)Scer\UAS.cGa mam (Helms et al., 1999) Su(H)Scer\UAS.cKa Bx42 (Negeri et al., 2002) fred (Chandra et al., 2003) H (Furriols and Bray, 2000) N (Furriols and Bray, 2000) Su(H)Scer\UAS.cNa eyg (Chao et al., 2004) numb (Nagel et al., 2000) Su(H)Scer\UAS.T:SV40\nls2 N (Furriols and Bray, 2000) Su(H)sK2 H (Verheyen et al., 1996) N (Verheyen et al., 1996) Su(H)sO10 H (Verheyen et al., 1996) N (Verheyen et al., 1996) Su(H)T4 H (Fortini and Artavanis-Tsakonas, 1994) M285 (Go and Artavanis-Tsakonas, 1998) mam (Fortini and Artavanis-Tsakonas, 1994, Verheyen et al., 1996) N (Fortini and Artavanis-Tsakonas, 1994, Matsuno et al., 1997) Su(H)unspecified rg (Shamloula et al., 2002) Su(H)ΔH.Scer\UAS N (Furriols and Bray, 2000) unspecified aya (Suzuki et al., 2000) Cir (Nellesen et al., 1998) Dl (Fortini and Artavanis-Tsakonas, 1994, Sun and Artavanis-Tsakonas, 1997, Tsuda et al., 2002) dx (Koelzer and Klein, 2006) grim (Mueller et al., 2005) H (Furukawa et al., 1992, Schweisguth et al., 1996, Mueller et al., 2005) Nle (Royet et al., 1998) p53 (Mueller et al., 2005) Psn (Koelzer and Klein, 2006) Ser (Sun and Artavanis-Tsakonas, 1997)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60899 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0004837 DroID - A comprehensive database of gene and protein interactions. • FBgn0004837 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34881 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P28159
Orthologs
OrthoDB Orthologs (48) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG64TPTJ Dipteran inclusive ortholog search EOG6NP7BX Insect inclusive ortholog search EOG6TDZFF Arthropod inclusive ortholog search EOG6CRJF6 Metazoa inclusive ortholog search EOG6N67Q8
Orthologs in Drosophila Species (EOG64TPTJ)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Su(H)     Drosophila simulans   Dsim\Su(H) Y   Drosophila sechellia   Dsec\GM15894 Y   Drosophila erecta   Dere\GG25142 Y   Drosophila yakuba   Dyak\GE20814 Y   Drosophila ananassae   Dana\GF14905 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA25243     Drosophila pseudoobscura pseudoobscura   Dpse\GA25242 Y   Drosophila persimilis   Dper\GL26026 Y   Drosophila willistoni   Dwil\GK18311 Y   Drosophila virilis   Dvir\GJ11880 Y   Drosophila mojavensis   Dmoj\GI13259 Y   Drosophila grimshawi   Dgri\GH10915 Y
Orthologs in non-Drosophila Dipterans (EOG6NP7BX)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL006419   Anopheles gambiae Malaria mosquito  Agam\AGAP008935   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ004183
Orthologs in non-Dipteran Insects (EOG6TDZFF)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB45655   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG019939   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG020439   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH20674   Atta cephalotes Leafcutter ant  Acep\ACEP17167   Camponotus floridanus Florida carpenter ant  Cflo\CFLO19627   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14375   Linepithema humile Argentine ant  Lhum\LH20421   Pogonomyrmex barbatus Red harvester ant  Pbar\PB18373   Solenopsis invicta Red fire ant  Sinv\SINV15808   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009607   Acyrthosiphon pisum Pea aphid  Apim\ACYPI001225   Bombyx mori Silkmoth  Bmor\BGIBMGA003113   Pediculus humanus Human body louse  Phum\PHUM462870   Tribolium castaneum Red flour beetle  Tcas\Su(H)
Orthologs in non-Insect Arthropods (EOG6CRJF6)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\rbcL   Ixodes scapularis Deer tick  Isca\ISCW010197
Orthologs in non-Arthropod Metazoa (EOG6N67Q8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\lag-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_021566gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016932gn   Danio rerio Zebrafish  Drer\rbpja   Danio rerio Zebrafish  Drer\rbpjl   Danio rerio Zebrafish  Drer\rbpjb   Xenopus tropicalis Western clawed frog  Xtro\rbpj   Gallus gallus Domestic chicken  Ggal\RBPJ   Gallus gallus Domestic chicken  Ggal\RBPJL   Mus musculus House mouse  Mmus\Rbpj   Mus musculus House mouse  Mmus\Rbpjl   Mus musculus House mouse  Mmus\Rbpsuh-rs3   Rattus norvegicus Norway rat  Rnor\Rbpj   Rattus norvegicus Norway rat  Rnor\Rbpjl   Homo sapiens Human  Hsap\ENSG00000124232
Human Orthologs (1)
Gene OMIM HGNC Hsap\ENSG00000124232
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\Su(H) Drosophila sechellia Dsec\GM15894 Drosophila erecta Dere\GG25142 Drosophila yakuba Dyak\GE20814 Drosophila ananassae Dana\GF14905 Drosophila pseudoobscura pseudoobscura Dpse\GA25242 Drosophila persimilis Dper\GL26026 Drosophila willistoni Dwil\GK18311 Drosophila virilis Dvir\GJ11880 Drosophila mojavensis Dmoj\GI13259 Drosophila grimshawi Dgri\GH10915
Stocks & Reagents
Stocks Listed in FlyBase ( 16 )
Bloomington	30477 pr1 cn1 Su(H)2/CyO 418 Su(H)1 whd1 l(2)Su(H)1/SM5 602 P{X6}Su(H)M28/T(2;3)B3, CyO: TM6B, Tb1 17389 y1 w67c23; P{EPgy2}Su(H)EY07695 10689 y1 w67c23; P{lacW}Su(H)k07904/CyO 417 Su(H)1/In(2L)Cy, In(2R)Cy, Cy1 pr1 28900 y1 v1; P{TRiP.HM05110}attP2/TM3, Sb1 26661 Su(H)IB115 fzy1 cn1 bw1 sp1/CyO
Kyoto	105901 Su(H)1 whd1 l(2)Su(H)1/SM5 101508 In(2L)Cy In(2R)Cy Cy1 pr1 / Su(H)1 105900 Su(H)1/In(2L)Cy, In(2R)Cy, Cy1 pr1
VDRC	v103597 P{KK101550}VIE-260B
	More stocks available...
Genomic Clones ( 1 )
	BACR03D18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 32 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH10914
Other clones	DPiM_GH10914
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM10826 LD17227 LD22806 LD24729 LP05527 RE17987 RE51658 RE55138 RE69055 SD13308
Other clones	1562 28837 76388 149905 173400 214351.29 214473.22 CK01.1D.A10 CK01.1D.A12 CK01.54B.F6 CK01.112A.C8 EK044155 EK065848 EK168703 EK173355 EK233102 EK255955 EK277625 EP03415 EP15919
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004837 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34881
Antibody Information
	polyclonal (Gho et al., 1996)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Su(H) CG3497 (Kodira, 1999.11)
Source for database merge of	Source for merge of: Su(H) anon-WO0257455.3 (FlyBase, 1996-)
Additional comments	Source for merge of Su(H) anon-WO0257455.3 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	The Su(H) product has a dual role, both as a N-independent repressor of transcription and as a N-dependent activator of transcription. (Koelzer and Klein, 2006) Mutant analysis suggests that dx signalling is dependent on the activity of Su(H). (Koelzer and Klein, 2006) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Su(H) has a N independent function during the development of bristle sensory organ precursor cells. (Koelzer and Klein, 2003) Neither E(spl) nor Su(H) seem to be involved in the N pathway that directs the neuron/glia choice in the PNS. (van de Bor and Giangrande, 2001) Su(H) has three distinct functions in the development of external mechanosensory organs; N-dependent transcriptional activation, an auto-repression function, both of which direct cell fate decisions, and an auto-activation function required for normal socket cell differentiation. (Barolo et al., 2000) The Su(H) phenotype is epistatic to that of H during wing disc development. (Klein et al., 2000) During wing development Su(H) can activate the expression of some N target genes independently of N. Activation of other N target genes depends on the joint activity of Su(H) and the intracellular fragment of the N protein; without the N fragment Su(H) acts as a repressor of these genes. Su(H) activity is inhibited by H, suggesting that the activation of Su(H) by N involves the release of Su(H) from an inhibitory complex which contains H. (Klein et al., 2000) Su(H) activity is required to upregulate sim expression in the mesectoderm, and to prevent ectopic expression of sim dorsally in the neurectoderm in cellularising embryos. (Morel and Schweisguth, 2000) Su(H) is essential to determine outer but not inner cell fates in the sensory organ cell lineage. (Nagel et al., 2000) N is processed in a ligand-dependent manner to generate a phosphorylated cytoplasmic domain that preferentially associates with Su(H). Localization studies suggest that the relative levels of Su(H), Dl and N regulate nuclear entry of the N/Su(H) complex. (Kidd et al., 1998) Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology. (Roch et al., 1998) N-inducible expression of HLHmδ and HLHmγ both in cultured cells and in vivo is dependent on functional Su(H) protein. (Eastman et al., 1997) Factors, in addition to Su(H), must exist to confer tissue-specific expression of vg and to regulate the spatial and temporal features of vg expression within the wing pouch. Su(H) has differential roles in the dorsal and ventral wing boundary cells. Su(H) represses the vg quadrant enhancer at the D/V boundary. (Kim et al., 1997) Su(H) is required for only a subset of the asymmetric divisions that depend on the function of numb and N. Su(H) appears to act downstream of numb in the same genetic pathway in determining the fates of the IIa daughter cells, the hair cell and the socket cell, and Su(H) is negatively regulated by numb. (Wang et al., 1997) Su(H) is required for all aspects of N function at the wing dorsoventral boundary. (de Celis et al., 1996) The genes of the E(spl) complex mediate only a subset of N activities during imaginal development. Comparisons of mutant phenotypes suggests that the N pathway bifurcates after the activation of Su(H) and that E(spl) activity is not required when the consequence of N function is the transcriptional activation of downstream genes. Transcriptional activation mediated by Su(H) and transcriptional repression mediated by E(spl) could provide greater diversity in the response of individual genes to N activity. (de Celis et al., 1996) Subcellular localisation of Su(H) during N signalling is analysed. (Gho et al., 1996) Su(H) binds to and activates the vg dorsal/ventral boundary enhancer. (Kim et al., 1996) Su(H) directly participates in N lateral signalling during sensory organ precursor (SOP) specification. N, H and Su(H) exhibit dose-dependent genetic interactions. (Schweisguth et al., 1996) The proximal upstream region of E(spl) complex genes contains multiple specific binding sites for Su(H). Integrity of these sites and Su(H) activity are required not only for normal levels of E(spl) complex gene expression in imaginal disc proneural clusters but also for their transcriptional response to hyperactivity of the N receptor. Su(H) is a direct regulatory link between N receptor activity and the expression of E(spl) complex genes, extending the known lineage of the N cell-cell signaling pathway. (Bailey and Posakony, 1995) Activation of N, mediated through Su(H), is sufficient to direct wg expression in the wing. (Diaz-Benjumea and Cohen, 1995) Su(H) protein binds to TGTGGGAA sequence located 616bp upstream of the transcription initiation site of E(spl). (Furukawa et al., 1995) Glutathione-S-transferase (GST) fusion proteins and the yeast two hybrid system demonstrate the H protein can inhibit the in vitro DNA binding activity of Su(H) through direct protein-protein interactions. Co-transfection assays in S2 cells demonstrate transcriptional activation driven by Su(H) is also inhibited by H. (Lecourtois et al., 1995) There is a strict genetic requirement for Su(H) activity for cell fate choices during early neurogenesis. (Lecourtois and Schweisguth, 1995) The dx gene product regulates the subcellular localisation of a transcription factor, Su(H), via antagonistic interactions with the N ankyrin repeats. (Matsuno and Artavanis-Tsakonas, 1995) Notum cells require Su(H) activity for receiving the lateral inhibitory signal. The DNA binding protein encoded by the Su(H) gene may act downstream of the N receptor to implement the epidermal non-sense organ precursor (SOP) fate. (Schweisguth, 1995) Yeast two-hybrid system assays and in vitro interaction studies demonstrate the sub-transmembrane region of N, structurally equivalent to the amino terminal part of mRAM23, is involved in the interaction with Su(H). (Tamura et al., 1995) Mutations can act as dominant modifiers of the activated N eye phenotype (FBrf0064452). (Verheyen et al., 1995) In vitro binding assays demonstrate the H gene product can inhibit the DNA binding of Su(H) through direct protein-protein interactions. Consistent with this, transcriptional activation driven by Su(H) in transfected S2 cells is inhibited by H. These results support a model in which H acts, in part, as a negative regulator of Su(H) activity. (Brou et al., 1994) In cultured Drosophila cells, the Su(H) product is sequestered in the cytoplasm when coexpressed with N protein and is translocated to the nucleus when N protein binds its Dl protein ligand. (Fortini and Artavanis-Tsakonas, 1994) Su(H) shows allele specific interactions with N, Dl, dx and mam. (Fortini and Artavanis-Tsakonas, 1994) N activity may regulate nuclear events by controlling the activity of the Su(H) DNA-binding protein. (Fortini and Artavanis-Tsakonas, 1994) Decreasing or increasing the level of Su(H) function confers mutant phenotypes that closely resemble those associated with gain and loss of H activity, respectively. (Schweisguth and Posakony, 1994) The sequence similarity between Su(H) and the integrase domain is not of functional significance as Tyr315 is not required for gene function in vivo. (Schweisguth et al., 1994) Genetic interactions with H suggest that Su(H) might be involved in cell fate specification in the adult PNS. (Schweisguth and Posakony, 1992) Isolated from a genomic library using the murine RBP-JΚ cDNA as a probe, under low stringency conditions. (Furukawa et al., 1991) Su(H) has been cloned and characterised. (Furukawa et al., 1991) Homozygous lethal; hemizygotes die in the pupal stage, between head eversion and the beginning of eye pigmentation. Heterozygotes in the absence of H are wild type in phenotype. Suppresses H; Su(H)/+; H/+ have 7-10 more bristles that H/+ alone; besides affecting the bristle phenotype of H, all alleles tend to enhance its wing-vein phenotype of shortening L4 and L5. Su(H) is without effect on the lethal phenotype of homozygous H. One homozygous-lethal allele acts as a dominant enhancer of H. Most alleles are amorphic or hypomorphic; heterozygous deficiencies for the locus also suppress and duplications enhance H (Nash, 1970). Enhanced genotypes have 10-15 fewer bristles and a far more extreme loss of microchaetae on the thorax than their unenhanced counterparts. The number of bristles in H/+ flies is inversely related to the dose of Su(H)+, with the number of bristles varying from fewer than ten with four doses to approximately 35 with one dose. Some combinations of hypomorphic alleles produce occasional escapers; survivors have distinctive phenotypes, which are described under entries for specific alleles.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057520 RefSeq (Proteins) • NP_476868 DDBJ / EMBL / GenBank • AA539138 AA817421 AA820823 AAA06211 AAA28919 AAD39698 AAD39699 AAD39700 AAD39701 AAD39702 AAD39703 AAD39704 AAD39705 AAD39706 AAD39707 AAD39708 AAD39709 AAD39710 AAD39711 AAD39712 AAD39713 AAD39714 AAD39715 AAD39716 AAD39717 AAF44914 AAF53434 AAL39236 AC092238 AE003411 AF088255 AF088256 AF088257 AF088258 AF088259 AF088260 AF088261 AF088262 AF088263 AF088264 AF088265 AF088266 AF088267 AF088268 AF088269 AF088270 AF088271 AF088272 AF088273 AF088274 AI114192 AQ025847 AW940393 AX482635 AY069091 CAA41282 CL525941 L26094 L26095 L26096 L26097 M94383 S69213 X58393 Z50244 Z50648 Entrez Gene - A searchable database of RefSeq genes. • 34881 UniProtKB/Swiss-Prot • P28159
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Cell surface receptor IPT/TIG (IPR002909) p53-like transcription factor, DNA-binding (IPR008967) Immunoglobulin-like fold (IPR013783) Immunoglobulin E-set (IPR014756) Beta-trefoil DNA-binding domain (IPR015350) LAG1, DNA binding (IPR015351) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH10914
Linkouts
	BioGRID - A database of protein and genetic interactions • 60899 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0004837 DroID - A comprehensive database of gene and protein interactions. • FBgn0004837 DRSC - Results from RNAi screens. • FBgn0004837 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004837 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3497-RB;CG3497-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004837 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34881 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /neural/suphair.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34881 modMine - Data generated by the modENCODE project. • FBgn0004837 REDfly - A database of transcriptional regulatory elements. • FBgn0004837 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P28159
Synonyms & Secondary IDs ( 38 )
Reported As
Symbol Synonym	anon-WO0257455.3   BG:DS00929.10 (Ashburner et al., 1999.10.12, Ashburner et al., 1999) br7 (Grau et al., 1984, Gubb et al., 1985, Ashburner and Harrington, 1984) C (Schweisguth and Posakony, 1992) CBF1 (Koelzer and Klein, 2006) CG3497 (Moorman et al., 2006, Mohammad et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009, de Wit et al., 2005) CSL (Maier et al., 2011, Kurth et al., 2011) D   dRBP-JΚ (Furukawa et al., 1991) dRBP-JK (Kumar and Moses, 2000) dRBP-Jk (Furukawa, 1991.3.13) E(H)   FTZ-F2 (Kumar and Moses, 2000) l(1)br7   l(2)35Bh (Ashburner et al., 1999, The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Alexandrova et al., 1996, ) l(2)br7 (Kumar and Moses, 2000, The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Gubb et al., 1984, Ashburner et al., 1983, Ashburner, 1982, Ashburner et al., 1982, Ashburner et al., 1982, Woodruff and Ashburner, 1979, ) l(2)k07904 (Chen et al., 1998, ) oss (Kumar and Moses, 2000) RBJK_DROME (Storm and Sonnhammer, 2003) RBP-JΚ (Furukawa et al., 1994) RBP-Jkappa   RBP-J kappa (Furukawa et al., 2005.9.16) Su(H) (Peel et al., 2005, Ward et al., 2006, Gao et al., 2005, Vied and Kalderon, 2007, Jemc and Rebay, 2007, Nagel et al., 2000, Koelzer and Klein, 2006, Joshi et al., 2006, Jafar-Nejad et al., 2006, Herranz and Milan, 2006, Thomas, 2005, Ahimou et al., 2004, Christensen and Cook, 2007.5.8, Giebel and Wodarz, 2006, Wesley and Mok, 2003, Tsuda et al., 2006, Monastirioti et al., 2010, Michellod et al., 2003, Apitz et al., 2005, Arbouzova and McNeill, 2007, Cohen et al., 2006, Ohlstein and Spradling, 2007, Ohlstein and Spradling, 2007, Gao and Laughon, 2006, Edenfeld et al., 2007, Stathopoulos and Levine, 2005, Lee and Lundell, 2007, Miller et al., 2009, San-Juán and Baonza, 2011, Ward et al., 2006, Voas and Rebay, 2004, Jordan et al., 2006, Fuwa et al., 2006, O'Keefe et al., 2011, Cave and Caudy, 2008, Grillenzoni et al., 2007, Terriente Felix and de Celis, 2008.1.16, Mueller et al., 2006, Nagel et al., 2005, Liu and Posakony, 2008, Eastman and Maeder, 2008, Yamada et al., 2008, Jafar-Nejad et al., 2005, Hutterer et al., 2006, Krejci and Bray, 2007, Giagtzoglou et al., 2012, Kaspar and Klein, 2006, Langdon et al., 2006, Tang et al., 2005, Philippakis et al., 2006, Maier et al., 2008, Tong et al., 2011, Zhang et al., 2011, Zeitouni et al., 2007, Firth and Baker, 2005, Hayward et al., 2006, David et al., 2005, Maier et al., 2011, Duan et al., 2011, Tokusumi et al., 2010, Kurth et al., 2011, Peng et al., 2012, Furriols et al., 2007, Kelly et al., 2007, Herranz et al., 2008, Gallagher and Knoblich, 2006, Jaekel and Klein, 2006, Zinzen et al., 2006, Sun and Deng, 2007, Goodfellow et al., 2007, Prince et al., 2008, Hayashi et al., 2008, del Alamo and Mlodzik, 2008, Wheeler et al., 2008, Tanaka et al., 2007, Le Gall et al., 2008, Parks et al., 2008, Remaud et al., 2008, Becam and Milán, 2008, Firth and Baker, 2009, Bhattacharya and Baker, 2009, Kaspar et al., 2008, Crocker et al., 2008, Mao and Freeman, 2009, Ayroles et al., 2009, Jin et al., 2009, Krejcí et al., 2009, Sukhanova and Du, 2008, Wang et al., 2008, Roegiers et al., 2009, Cai and Laughon, 2009, Li et al., 2009, Andrews et al., 2009, Vied and Kalderon, 2009, Schaaf et al., 2009, Zeitlinger et al., 2007, Patel et al., 2009, Boyle and Berg, 2009, Twombly et al., 2009, Shyu et al., 2009, Baonza and Freeman, 2005, Mummery-Widmer et al., 2009, Sanders et al., 2009, Martinez et al., 2009, Babaoglan et al., 2009, Birch-Machin et al., 2005, Moshkin et al., 2009, Ma et al., 2009, Song et al., 2009, Simon et al., 2009, de Wit et al., 2005, Beebe et al., 2010, Saj et al., 2010, Swanson et al., 2010, Liefke et al., 2010, Tong et al., 2010, Rebeiz et al., 2011, Pierce et al., 2010.8.10, Terriente-Félix et al., 2010, Weinmaster, 1997, Bardin et al., 2010, Bernard et al., 2010, Mourikis et al., 2010, Nicholson et al., 2011, Di Stefano et al., 2011, Cave et al., 2011, Kim et al., 2010, Aerts et al., 2010, Talora et al., 2008, Wang et al., 2011, Perdigoto et al., 2011, Jiang et al., 2011, Kuzina et al., 2011, Benhra et al., 2011, Ren et al., 2011, Park et al., 2011, Rand et al., 2008, Balakireva et al., 2006, Tokusumi et al., 2012, Rincon-Arano et al., 2012, Heck et al., 2012, Popkova et al., 2012, Bhattacharya and Baker, 2011, Ozdemir et al., 2011, Quijano et al., 2011, Zacharioudaki et al., 2012, Rebeiz et al., 2012, Aboukhalil and Bulyk, 2012, Liu and Posakony, 2012, Chang et al., 2008) SU(H) (Shilo, 2005, Kim et al., 2010, Marygold et al., 2011) Su(h) (Gravot et al., 2004) su(H) (Ruvkun and Hobert, 1998, Wesley and Mok, 2003, Djiane et al., 2011) SuH (Armstrong et al., 2005, Chinnadurai, 2002, Manning and Doe, 1999, Fagotto and Gumbiner, 1996, Woodruff and Ashburner, 1979, Axelson, 2006, LeComte et al., 2006) SUH (Wesley and Mok, 2003)
Name Synonym	lethal 7 in the black-reduced region (Woodruff and Ashburner, 1979) lethal group D   suppressor of hairless (Li and White, 2003) Suppressor of Hairless (Rogers and Barolo, 2006, Wesley and Mok, 2003, Fuwa et al., 2006, Cave and Caudy, 2008, Mueller et al., 2006, Nagel et al., 2005, Liu and Posakony, 2008, Yamada et al., 2008, Hutterer et al., 2006, Kaspar and Klein, 2006, Langdon et al., 2006, LeComte et al., 2006, Philippakis et al., 2006, Zeitouni et al., 2007, Hayward et al., 2006, Tokusumi et al., 2010, Kurth et al., 2011, Herranz et al., 2008, Hayashi et al., 2008, Wheeler et al., 2008, Parks et al., 2008, Jin et al., 2009, Cai and Laughon, 2009, Miller et al., 2009, Schaaf et al., 2009, Boyle and Berg, 2009, Baonza and Freeman, 2005, Mummery-Widmer et al., 2009, Song et al., 2009, Simon et al., 2009, Swanson et al., 2010, Liefke et al., 2010, Tong et al., 2010, Terriente-Félix et al., 2010, Weinmaster, 1997, Bardin et al., 2010, Bernard et al., 2010, Mourikis et al., 2010, Aerts et al., 2010, Talora et al., 2008, Bhattacharya and Baker, 2011, Endo et al., 2011, Aboukhalil and Bulyk, 2012, Chang et al., 2008) Suppressor of hairless (Radtke et al., 2005, Garcia and Stathopoulos, 2011, Felix et al., 2012) suppressor-of-hairless (Ishihara and Shibata, 2008) Suppressor-of-Hairless (Bhattacharya and Baker, 2009) suppressor of Hairless (Patel et al., 2009) Supressor of Hairless (Herranz and Milan, 2006, Axelson, 2006, Maier et al., 2008, Mok et al., 2005) transcription unit C (Schweisguth and Posakony, 1992)
Secondary FlyBase IDs
	FBgn0003566 FBgn0004467 FBgn0021969 FBgn0022068 FBgn0063792
References ( 626 )
Generate a list of	All references relating to this gene ( 626 )
List References by type	Research paper  ( 359 ) Supplementary material  ( 12 ) Review  ( 110 ) Personal communication to FlyBase  ( 22 ) Abstract  ( 105 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Stock list  ( 1 ) Curated genome annotation  ( 3 ) Website  ( 1 ) Book  ( 1 ) Letter  ( 3 ) Patent  ( 1 ) Conference report  ( 4 )
Recent research papers ( 45 )
	Djiane et al., 2013, EMBO J. 32(1): 60--71 Dissecting the mechanisms of Notch induced hyperplasia. [FBrf0220483] Housden et al., 2013, PLoS Genet. 9(1): e1003162 Transcriptional Dynamics Elicited by a Short Pulse of Notch Activation Involves Feed-Forward Regulation by E(spl)/Hes Genes. [FBrf0220474] Aboukhalil and Bulyk, 2012, Bioinformatics 28(11): 1446--1454 LOESS correction for length variation in gene set-based genomic sequence analysis. [FBrf0218376] Felix et al., 2012, Genetics 191(3): 989--1002 Age-Specific Variation in Immune Response in Drosophila melanogaster Has a Genetic Basis. [FBrf0218944] Giagtzoglou et al., 2012, J. Cell Biol. 196(1): 65--83 dEHBP1 Controls Exocytosis and Recycling of Delta During Asymmetric Divisions. [FBrf0217836] Goulas et al., 2012, Cell Stem Cell 11(4): 529--540 The par complex and integrins direct asymmetric cell division in adult intestinal stem cells. [FBrf0219511] Heck et al., 2012, Biol. Open 1(3): 182--196 The transcriptional corepressor SMRTER influences both Notch and ecdysone signaling during Drosophila development. [FBrf0220179] Lin et al., 2012, PLoS Biol. 10(11): e1001425 Lineage analysis of Drosophila lateral antennal lobe neurons reveals notch-dependent binary temporal fate decisions. [FBrf0219980] Liu and Posakony, 2012, PLoS Genet. 8(7): e1002796 Role of architecture in the function and specificity of two notch-regulated transcriptional enhancer modules. [FBrf0218891] Peng et al., 2012, Dev. Cell 23(3): 507--518 Planar Polarized Protrusions Break the Symmetry of EGFR Signaling during Drosophila Bract Cell Fate Induction. [FBrf0219458] Popkova et al., 2012, PLoS Genet. 8(12): e1003159 Polycomb controls gliogenesis by regulating the transient expression of the gcm/glide fate determinant. [FBrf0220515] Rebeiz et al., 2012, Dev. Biol. 362(2): 282--294 Ancestral and conserved cis-regulatory architectures in developmental control genes. [FBrf0217764] Rincon-Arano et al., 2012, Cell 151(6): 1214--1228 UpSET Recruits HDAC Complexes and Restricts Chromatin Accessibility and Acetylation at Promoter Regions. [FBrf0220189] Tokusumi et al., 2012, PLoS ONE 7(7): e41604 Gene regulatory networks controlling hematopoietic progenitor niche cell production and differentiation in the Drosophila lymph gland. [FBrf0219204] Ulvklo et al., 2012, Development 139(4): 678--689 Control of neuronal cell fate and number by integration of distinct daughter cell proliferation modes with temporal progression. [FBrf0217281] Zacharioudaki et al., 2012, Development 139(7): 1258--1269 bHLH-O proteins are crucial for Drosophila neuroblast self-renewal and mediate Notch-induced overproliferation. [FBrf0217605] Benhra et al., 2011, Curr. Biol. 21(1): 87--95 AP-1 Controls the Trafficking of Notch and Sanpodo toward E-Cadherin Junctions in Sensory Organ Precursors. [FBrf0212697] Bhattacharya and Baker, 2011, Cell 147(4): 881--892 A Network of Broadly Expressed HLH Genes Regulates Tissue-Specific Cell Fates. [FBrf0216641] Cave et al., 2011, Mol. Cell. Biol. 31(1): 22--29 Differential Regulation of Transcription through Distinct Suppressor of Hairless DNA Binding Site Architectures during Notch Signaling in Proneural Clusters. [FBrf0212524] Di Stefano et al., 2011, Genes Dev. 25(1): 17--28 Functional antagonism between histone H3K4 demethylases in vivo. [FBrf0212709] Djiane et al., 2011, J. Cell Biol. 192(1): 189--200 Su(dx) E3 ubiquitin ligase-dependent and -independent functions of Polychaetoid, the Drosophila ZO-1 homologue. [FBrf0212737] Duan et al., 2011, EMBO J. 30(15): 3120--3133 Insensitive is a corepressor for Suppressor of Hairless and regulates Notch signalling during neural development. [FBrf0214638] Endo et al., 2011, Nat. Neurosci. 15(2): 224--233 Chromatin modification of Notch targets in olfactory receptor neuron diversification. [FBrf0217319] Garcia and Stathopoulos, 2011, PLoS ONE 6(12): e29172 Lateral gene expression in Drosophila early embryos is supported by grainyhead-mediated activation and tiers of dorsally-localized repression. [FBrf0217082] Hori et al., 2011, J. Cell Biol. 195(6): 1005--1015 Synergy between the ESCRT-III complex and Deltex defines a ligand-independent Notch signal. [FBrf0216916] Janody and Treisman, 2011, Dev. Dyn. 240(9): 2051--2059 Requirements for mediator complex subunits distinguish three classes of notch target genes at the Drosophila wing margin. [FBrf0216388] Jiang et al., 2011, Cell Stem Cell 8(1): 84--95 EGFR/Ras/MAPK Signaling Mediates Adult Midgut Epithelial Homeostasis and Regeneration in Drosophila. [FBrf0212694] Kurth et al., 2011, PLoS ONE 6(11): e27986 Molecular analysis of the notch repressor-complex in Drosophila: characterization of potential hairless binding sites on suppressor of hairless. [FBrf0216786] Kuzina et al., 2011, Development 138(9): 1839--1849 How Notch establishes longitudinal axon connections between successive segments of the Drosophila CNS. [FBrf0213493] Maier et al., 2011, Mol. Biol. Cell 22(17): 3242--3252 Structural and functional analysis of the repressor complex in the Notch signaling pathway of Drosophila melanogaster. [FBrf0215044] Marygold et al., 2011, Fly 5(4): 291--303 Genetic characterization of ebi reveals its critical role in Drosophila wing growth. [FBrf0216882] Mulligan et al., 2011, Mol. Cell 42(5): 689--699 A SIRT1-LSD1 Corepressor Complex Regulates Notch Target Gene Expression and Development. [FBrf0213865] Nicholson et al., 2011, Development 138(2): 251--260 Notch-dependent expression of the archipelago ubiquitin ligase subunit in the Drosophila eye. [FBrf0212669] O'Keefe et al., 2011, Mech. Dev. 128(1-2): 59--70 EndoGI modulates Notch signaling and axon guidance in Drosophila. [FBrf0213012] Ozdemir et al., 2011, Genome Res. 21(4): 566--577 High resolution mapping of Twist to DNA in Drosophila embryos: Efficient functional analysis and evolutionary conservation. [FBrf0213359] Park et al., 2011, PLoS Genet. 7(8): e1002241 Specification of Drosophila corpora cardiaca neuroendocrine cells from mesoderm is regulated by Notch signaling. [FBrf0215231] Perdigoto et al., 2011, Development 138(21): 4585--4595 Distinct levels of Notch activity for commitment and terminal differentiation of stem cells in the adult fly intestine. [FBrf0216374] Quijano et al., 2011, Genetics 189(3): 809--824 Wg Signaling via Zw3 and Mad Restricts Self-Renewal of Sensory Organ Precursor Cells in Drosophila. [FBrf0216675] Rebeiz et al., 2011, Development 138(2): 215--225 Notch regulates numb: integration of conditional and autonomous cell fate specification. [FBrf0212636] Ren et al., 2011, Hum. Mol. Genet. 20(17): 3424--3436 A Drosophila model of the neurodegenerative disease SCA17 reveals a role of RBP-J/Su(H) in modulating the pathological outcome. [FBrf0214639] San-Juán and Baonza, 2011, Dev. Biol. 352(1): 70--82 The bHLH factor deadpan is a direct target of Notch signaling and regulates neuroblast self-renewal in Drosophila. [FBrf0213150] Swanson et al., 2011, Curr. Biol. 21(14): 1186--1196 Rapid evolutionary rewiring of a structurally constrained eye enhancer. [FBrf0214461] Tong et al., 2011, EMBO Rep. 12(5): 428--435 Ataxin-1 and Brother of ataxin-1 are components of the Notch signalling pathway. [FBrf0213567] Wang et al., 2011, Dev. Biol. 350(2): 414--428 Notch signaling regulates neuroepithelial stem cell maintenance and neuroblast formation in Drosophila optic lobe development. [FBrf0212909] Zhang et al., 2011, PLoS ONE 6(10): e26197 Mastermind Mutations Generate a Unique Constellation of Midline Cells within the Drosophila CNS. [FBrf0216654] Show all research papers ...
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