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Gene Dmel\otk

General Information
Symbol	Dmel\otk	Species	D. melanogaster
Name	off-track	Annotation symbol	CG8967
Feature type	protein_coding_gene	FlyBase ID	FBgn0004839
Gene Model Status	Current	Stock availability	12 publicly available
Also Known As	Dtrk
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	48D6-48D7	Sequence location	2R:7,888,983..7,907,329 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene off-track is referred to in FlyBase by the symbol Dmel\otk (CG8967, FBgn0004839). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: cell adhesion molecule binding; receptor activity; protein kinase activity. There is experimental evidence that it is involved in the biological process: axon guidance; cell adhesion. 16 alleles are reported. The phenotypes of these alleles are annotated with: intersegmental nerve; abdominal segmental nerve; axon. It has one annotated transcript and one annotated polypeptide. Protein features are: Immunoglobulin I-set; Immunoglobulin subtype; Immunoglobulin subtype 2; Immunoglobulin-like; Immunoglobulin-like fold; Protein kinase, catalytic domain; Protein kinase-like domain; Serine-threonine/tyrosine-protein kinase; Tyrosine-protein kinase, active site; Tyrosine-protein kinase, catalytic domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 06-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1633753_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of otk. Gene sequence location is 2R:7888983..7907329.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Knowles-Barley, 2011.8.24, BrainTrap expression curation.
FB2012_01	References Peradziryi et al., 2011, EMBO J. 30(18): 3729--3740 Sequence features BKN50322 BKN23383 BKN50053 HFA07658
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 48D6-48D7   Limits computationally determined from genome sequence between P{lacW}l(2)k06612k06612 and P{lacW}jebk05644
Experimentally Determined Cytological Location
Cytogenetic map Notes References 48D-48D   (determined by in situ hybridisation)   (Pulido et al., 1992)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\otk for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Has significant BLAST similarity to the upstream gene CG8964.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) otk-RA FBtr0088028  NM_078981   4644   1033
Additional Transcript Data & Comments
Reported size (kB)	5.7 (northern blot) (Pulido et al., 1992)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein otk-PA   FBpp0087135   114.3   1033   6.88     NP_523705   AAF58596
Additional Polypeptide Data & Comments
Reported size (kDa)	1033 (aa); 160 (kD observed) (Pulido et al., 1992)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Immunoglobulin subtype 2 (IPR003598) Immunoglobulin subtype (IPR003599) Immunoglobulin-like (IPR007110) Tyrosine-protein kinase, active site (IPR008266) Protein kinase-like domain (IPR011009) Immunoglobulin-like fold (IPR013783) Tyrosine-protein kinase, catalytic domain (IPR020635) Serine-threonine/tyrosine-protein kinase (IPR001245) Immunoglobulin I-set (IPR013098)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF58596   AI404212   AQ074029   BT015249 AAT94478   BT083425   CK661771   CO184108   CO192175   CO194574   CO305400   CO310470   CO344963   CQ847776   CZ482896   EC053991   EC054489   EC054972   EC062718   EC064675   EC072593   EC203414   EC213736   EC255182   EC255985   ES693787   ES694048   GH752389   GH839082   GH870999   GH879521   GH939725   X63453 CAA45053
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q6AWJ9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage & pupal stage     (Pulido et al., 1992)
Additional Descriptive Data
	Two major peaks of otk expression are seen on northern blots. They occur in early-mid embryos and in early pupae. (Pulido et al., 1992)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage | late   peripheral nervous system | restricted   (Pulido et al., 1992) cell body   (Pulido et al., 1992) anterior commissure   (Pulido et al., 1992) posterior commissure   (Pulido et al., 1992) neuron   • axon (Pulido et al., 1992) embryonic stage 7   cephalic furrow   (Pulido et al., 1992) embryonic stage 7 -- 11   anterior midgut primordium   (Pulido et al., 1992) embryonic stage 11   procephalic segment   (Pulido et al., 1992) posterior midgut primordium   (Pulido et al., 1992) epidermis | restricted   (Pulido et al., 1992) neuroblast   (Pulido et al., 1992) embryonic stage 12   maxillary segment   (Pulido et al., 1992) epidermis | segmentally repeated   (Pulido et al., 1992) proctodeum | precursor   (Pulido et al., 1992) embryonic stage 12 -- 17   neuron   (Pulido et al., 1992) embryonic stage 13   ventral nerve cord   (Pulido et al., 1992) embryonic/larval midgut   (Pulido et al., 1992) embryonic/larval hindgut   (Pulido et al., 1992) visceral mesoderm   (Pulido et al., 1992)
Additional Descriptive Data
	otk protein expression is first detected at embryonic stage 7 in the anterior midgut primordium, cephalic furrow, and along the germ band. At stage 11, expression is observed in 15 stripes corresponding to parasegments 1-15, including external epidermal cells and internalized neuroblasts of the CNS. Within each parasegment, staining is in the posterior compartment. On the epidermis, staining comprises ventral and lateral regions but does not include the midline. Later, staining is observed in the anterior compartment. At the beginni g of germ band retraction, expression is observed in segmentally repeated patches of neuroepithelial cells and more strongly in underlying neuronal cells. It is also detected transiently in the maxillary bud. In stage 13, protein disappears from the epithelium and condenses in the ventral nerve cord. It is also observed in three discontinuous gut areas including the anterior midgut, posterior midgut and hindgut where it is restricted to the visceral mesoderm. At later stages, expression is barely detectable in mesodermal tissues but is strong in the ventral cord. Protein is present throughou the CNS on neuronal cell bodies and their axons. Staining is stronger in anterior commissures than posterior commissures. Protein is also detected on axons leaving the CNS through the segmental and intersegmental nerves, in neurons of a subset of sensory organs of the PNS, and on fasciculating axons growing toward muscle targets. (Pulido et al., 1992)
Marker for
Subcellular Localization
CV Term	plasma membrane (Pulido et al., 1992)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0004839    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0004839 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 06-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0004839 expression level Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr    598 embryo 04-06hr    1201 embryo 06-08hr    2939 embryo 08-10hr    4463 embryo 10-12hr    5703 embryo 12-14hr    5881 embryo 14-16hr    3242 embryo 16-18hr    1487 embryo 18-20hr    988 embryo 20-22hr    554 embryo 22-24hr    694 larva L1    570 larva L2    209 larva L3 12hr old    140 larva L3 puffstage 1-2    396 larva L3 puffstage 3-6    903 larva L3 puffstage 7-9    1281 white prepupae new    1604 white prepupae 12hr    2710 white prepupae 24hr    3234 pupae 2d postWPP    1522 pupae 3d postWPP    216 pupae 4d postWPP    201 adult male 01day    126 adult male 05day    162 adult male 30day    150 adult female 01day    78 adult female 05day    32 adult female 30day    29 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr  (598) embryo 04-06hr  (1201) embryo 06-08hr  (2939) embryo 08-10hr  (4463) embryo 10-12hr  (5703) embryo 12-14hr  (5881) embryo 14-16hr  (3242) embryo 16-18hr  (1487) embryo 18-20hr  (988) embryo 20-22hr  (554) embryo 22-24hr  (694) larva L1  (570) larva L2  (209) larva L3 12hr old  (140) larva L3 puffstage 1-2  (396) larva L3 puffstage 3-6  (903) larva L3 puffstage 7-9  (1281) white prepupae new  (1604) white prepupae 12hr  (2710) white prepupae 24hr  (3234) pupae 2d postWPP  (1522) pupae 3d postWPP  (216) pupae 4d postWPP  (201) adult male 01day  (126) adult male 05day  (162) adult male 30day  (150) adult female 01day    78 adult female 05day    32 adult female 30day    29 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr    598 embryo 04-06hr    1201 embryo 06-08hr  (2939) embryo 08-10hr  (4463) embryo 10-12hr  (5703) embryo 12-14hr  (5881) embryo 14-16hr  (3242) embryo 16-18hr  1487 embryo 18-20hr    988 embryo 20-22hr    554 embryo 22-24hr    694 larva L1    570 larva L2    209 larva L3 12hr old    140 larva L3 puffstage 1-2    396 larva L3 puffstage 3-6    903 larva L3 puffstage 7-9    1281 white prepupae new  (1604) white prepupae 12hr  (2710) white prepupae 24hr  (3234) pupae 2d postWPP  (1522) pupae 3d postWPP    216 pupae 4d postWPP    201 adult male 01day    126 adult male 05day    162 adult male 30day    150 adult female 01day    78 adult female 05day    32 adult female 30day    29 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr    598 embryo 04-06hr    1201 embryo 06-08hr    2939 embryo 08-10hr    4463 embryo 10-12hr    5703 embryo 12-14hr    5881 embryo 14-16hr    3242 embryo 16-18hr    1487 embryo 18-20hr    988 embryo 20-22hr    554 embryo 22-24hr    694 larva L1    570 larva L2    209 larva L3 12hr old    140 larva L3 puffstage 1-2    396 larva L3 puffstage 3-6    903 larva L3 puffstage 7-9    1281 white prepupae new    1604 white prepupae 12hr    2710 white prepupae 24hr    3234 pupae 2d postWPP    1522 pupae 3d postWPP    216 pupae 4d postWPP    201 adult male 01day    126 adult male 05day    162 adult male 30day    150 adult female 01day    78 adult female 05day    32 adult female 30day    29 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr    598 embryo 04-06hr    1201 embryo 06-08hr    2939 embryo 08-10hr    4463 embryo 10-12hr    5703 embryo 12-14hr    5881 embryo 14-16hr    3242 embryo 16-18hr    1487 embryo 18-20hr    988 embryo 20-22hr    554 embryo 22-24hr    694 larva L1    570 larva L2    209 larva L3 12hr old    140 larva L3 puffstage 1-2    396 larva L3 puffstage 3-6    903 larva L3 puffstage 7-9    1281 white prepupae new    1604 white prepupae 12hr    2710 white prepupae 24hr    3234 pupae 2d postWPP    1522 pupae 3d postWPP    216 pupae 4d postWPP    201 adult male 01day    126 adult male 05day    162 adult male 30day    150 adult female 01day    78 adult female 05day    32 adult female 30day    29 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0004839 expression level Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr    598 embryo 04-06hr    1201 embryo 06-08hr    2939 embryo 08-10hr    4463 embryo 10-12hr    5703 embryo 12-14hr    5881 embryo 14-16hr    3242 embryo 16-18hr    1487 embryo 18-20hr    988 embryo 20-22hr    554 embryo 22-24hr    694 larva L1    570 larva L2    209 larva L3 12hr old    140 larva L3 puffstage 1-2    396 larva L3 puffstage 3-6    903 larva L3 puffstage 7-9    1281 white prepupae new    1604 white prepupae 12hr    2710 white prepupae 24hr    3234 pupae 2d postWPP    1522 pupae 3d postWPP    216 pupae 4d postWPP    201 adult male 01day    126 adult male 05day    162 adult male 30day    150 adult female 01day    78 adult female 05day    32 adult female 30day    29 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr  (598) embryo 04-06hr  (1201) embryo 06-08hr  (2939) embryo 08-10hr  (4463) embryo 10-12hr  (5703) embryo 12-14hr  (5881) embryo 14-16hr  (3242) embryo 16-18hr  (1487) embryo 18-20hr  (988) embryo 20-22hr  (554) embryo 22-24hr  (694) larva L1  (570) larva L2  (209) larva L3 12hr old  140 larva L3 puffstage 1-2  (396) larva L3 puffstage 3-6  (903) larva L3 puffstage 7-9  (1281) white prepupae new  (1604) white prepupae 12hr  (2710) white prepupae 24hr  (3234) pupae 2d postWPP  (1522) pupae 3d postWPP  (216) pupae 4d postWPP  (201) adult male 01day  126 adult male 05day  (162) adult male 30day  (150) adult female 01day    78 adult female 05day    32 adult female 30day    29 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr    598 embryo 04-06hr    1201 embryo 06-08hr  (2939) embryo 08-10hr  (4463) embryo 10-12hr  (5703) embryo 12-14hr  (5881) embryo 14-16hr  (3242) embryo 16-18hr  1487 embryo 18-20hr    988 embryo 20-22hr    554 embryo 22-24hr    694 larva L1    570 larva L2    209 larva L3 12hr old    140 larva L3 puffstage 1-2    396 larva L3 puffstage 3-6    903 larva L3 puffstage 7-9    1281 white prepupae new  1604 white prepupae 12hr  (2710) white prepupae 24hr  (3234) pupae 2d postWPP  1522 pupae 3d postWPP    216 pupae 4d postWPP    201 adult male 01day    126 adult male 05day    162 adult male 30day    150 adult female 01day    78 adult female 05day    32 adult female 30day    29 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr    598 embryo 04-06hr    1201 embryo 06-08hr    2939 embryo 08-10hr    4463 embryo 10-12hr    5703 embryo 12-14hr    5881 embryo 14-16hr    3242 embryo 16-18hr    1487 embryo 18-20hr    988 embryo 20-22hr    554 embryo 22-24hr    694 larva L1    570 larva L2    209 larva L3 12hr old    140 larva L3 puffstage 1-2    396 larva L3 puffstage 3-6    903 larva L3 puffstage 7-9    1281 white prepupae new    1604 white prepupae 12hr    2710 white prepupae 24hr    3234 pupae 2d postWPP    1522 pupae 3d postWPP    216 pupae 4d postWPP    201 adult male 01day    126 adult male 05day    162 adult male 30day    150 adult female 01day    78 adult female 05day    32 adult female 30day    29 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr    598 embryo 04-06hr    1201 embryo 06-08hr    2939 embryo 08-10hr    4463 embryo 10-12hr    5703 embryo 12-14hr    5881 embryo 14-16hr    3242 embryo 16-18hr    1487 embryo 18-20hr    988 embryo 20-22hr    554 embryo 22-24hr    694 larva L1    570 larva L2    209 larva L3 12hr old    140 larva L3 puffstage 1-2    396 larva L3 puffstage 3-6    903 larva L3 puffstage 7-9    1281 white prepupae new    1604 white prepupae 12hr    2710 white prepupae 24hr    3234 pupae 2d postWPP    1522 pupae 3d postWPP    216 pupae 4d postWPP    201 adult male 01day    126 adult male 05day    162 adult male 30day    150 adult female 01day    78 adult female 05day    32 adult female 30day    29 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0004839    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0004839 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0004839 expression level Tissue   Expression Level Larval Central Nervous System    592.425 Larval Midgut    26.9 Larval Hindgut    54.5 Larval Malpighian Tubules    7.1 Larval Fat Body    14.3 Larval Salivary Gland    8.7 Larval Trachea    18.1 Larval Carcass    18.05 Adult Head    9.6 Adult Eye    3.175 Adult Brain    48 Adult Thoracic-Abdominal Ganglion    24.2 Adult Crop    19.7 Adult Midgut    14.7 Adult Hindgut    60.1 Adult Malpighian Tubules    21.7 Adult Fat Body    33.4 Adult Salivary Gland no informative data Adult Heart    26.425 Adult VirginFemale Spermatheca    9.1 Adult InseminatedFemale Spermatheca    6.4 Adult Ovary    3.8 Adult Testis    8.7 Adult Male Accessory Gland    6.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (592.425) Larval Midgut    26.9 Larval Hindgut    54.5 Larval Malpighian Tubules    7.1 Larval Fat Body    14.3 Larval Salivary Gland    8.7 Larval Trachea    18.1 Larval Carcass    18.05 Adult Head    9.6 Adult Eye    3.175 Adult Brain    48 Adult Thoracic-Abdominal Ganglion    24.2 Adult Crop    19.7 Adult Midgut    14.7 Adult Hindgut    60.1 Adult Malpighian Tubules    21.7 Adult Fat Body    33.4 Adult Salivary Gland no informative data Adult Heart    26.425 Adult VirginFemale Spermatheca    9.1 Adult InseminatedFemale Spermatheca    6.4 Adult Ovary    3.8 Adult Testis    8.7 Adult Male Accessory Gland    6.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    592.425 Larval Midgut    26.9 Larval Hindgut    54.5 Larval Malpighian Tubules    7.1 Larval Fat Body    14.3 Larval Salivary Gland    8.7 Larval Trachea    18.1 Larval Carcass    18.05 Adult Head    9.6 Adult Eye    3.175 Adult Brain    48 Adult Thoracic-Abdominal Ganglion    24.2 Adult Crop    19.7 Adult Midgut    14.7 Adult Hindgut    60.1 Adult Malpighian Tubules    21.7 Adult Fat Body    33.4 Adult Salivary Gland no informative data Adult Heart    26.425 Adult VirginFemale Spermatheca    9.1 Adult InseminatedFemale Spermatheca    6.4 Adult Ovary    3.8 Adult Testis    8.7 Adult Male Accessory Gland    6.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    592.425 Larval Midgut    26.9 Larval Hindgut    54.5 Larval Malpighian Tubules    7.1 Larval Fat Body    14.3 Larval Salivary Gland    8.7 Larval Trachea    18.1 Larval Carcass    18.05 Adult Head    9.6 Adult Eye    3.175 Adult Brain    48 Adult Thoracic-Abdominal Ganglion    24.2 Adult Crop    19.7 Adult Midgut    14.7 Adult Hindgut    60.1 Adult Malpighian Tubules    21.7 Adult Fat Body    33.4 Adult Salivary Gland no informative data Adult Heart    26.425 Adult VirginFemale Spermatheca    9.1 Adult InseminatedFemale Spermatheca    6.4 Adult Ovary    3.8 Adult Testis    8.7 Adult Male Accessory Gland    6.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0004839 expression level Tissue   Expression Level Larval Central Nervous System    592.425 Larval Midgut    26.9 Larval Hindgut    54.5 Larval Malpighian Tubules    7.1 Larval Fat Body    14.3 Larval Salivary Gland    8.7 Larval Trachea    18.1 Larval Carcass    18.05 Adult Head    9.6 Adult Eye    3.175 Adult Brain    48 Adult Thoracic-Abdominal Ganglion    24.2 Adult Crop    19.7 Adult Midgut    14.7 Adult Hindgut    60.1 Adult Malpighian Tubules    21.7 Adult Fat Body    33.4 Adult Salivary Gland no informative data Adult Heart    26.425 Adult VirginFemale Spermatheca    9.1 Adult InseminatedFemale Spermatheca    6.4 Adult Ovary    3.8 Adult Testis    8.7 Adult Male Accessory Gland    6.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  592.425 Larval Midgut    26.9 Larval Hindgut    54.5 Larval Malpighian Tubules    7.1 Larval Fat Body    14.3 Larval Salivary Gland    8.7 Larval Trachea    18.1 Larval Carcass    18.05 Adult Head    9.6 Adult Eye    3.175 Adult Brain    48 Adult Thoracic-Abdominal Ganglion    24.2 Adult Crop    19.7 Adult Midgut    14.7 Adult Hindgut    60.1 Adult Malpighian Tubules    21.7 Adult Fat Body    33.4 Adult Salivary Gland no informative data Adult Heart    26.425 Adult VirginFemale Spermatheca    9.1 Adult InseminatedFemale Spermatheca    6.4 Adult Ovary    3.8 Adult Testis    8.7 Adult Male Accessory Gland    6.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    592.425 Larval Midgut    26.9 Larval Hindgut    54.5 Larval Malpighian Tubules    7.1 Larval Fat Body    14.3 Larval Salivary Gland    8.7 Larval Trachea    18.1 Larval Carcass    18.05 Adult Head    9.6 Adult Eye    3.175 Adult Brain    48 Adult Thoracic-Abdominal Ganglion    24.2 Adult Crop    19.7 Adult Midgut    14.7 Adult Hindgut    60.1 Adult Malpighian Tubules    21.7 Adult Fat Body    33.4 Adult Salivary Gland no informative data Adult Heart    26.425 Adult VirginFemale Spermatheca    9.1 Adult InseminatedFemale Spermatheca    6.4 Adult Ovary    3.8 Adult Testis    8.7 Adult Male Accessory Gland    6.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    592.425 Larval Midgut    26.9 Larval Hindgut    54.5 Larval Malpighian Tubules    7.1 Larval Fat Body    14.3 Larval Salivary Gland    8.7 Larval Trachea    18.1 Larval Carcass    18.05 Adult Head    9.6 Adult Eye    3.175 Adult Brain    48 Adult Thoracic-Abdominal Ganglion    24.2 Adult Crop    19.7 Adult Midgut    14.7 Adult Hindgut    60.1 Adult Malpighian Tubules    21.7 Adult Fat Body    33.4 Adult Salivary Gland no informative data Adult Heart    26.425 Adult VirginFemale Spermatheca    9.1 Adult InseminatedFemale Spermatheca    6.4 Adult Ovary    3.8 Adult Testis    8.7 Adult Male Accessory Gland    6.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    9.6   NA  Eye    3.175   NA  Brain    48   592.425  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    24.2   NA  Crop    19.7   26.9  Midgut    14.7   54.5  Hindgut    60.1   7.1  Malpighian Tubules    21.7   14.3  Fat Body    33.4   8.7  Salivary Gland    no informative data   NA  Heart    26.425   18.1  Trachea    NA   NA  VirginFemale Spermatheca    9.1   NA  InseminatedFemale Spermatheca    6.4   NA  Ovary    3.8   NA  Testis    8.7   NA  Male Accessory Gland    6.4   18.05  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_11
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004839 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8967-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele semi-lethal, with Scer\GAL4elav.PLu otkEP2017 viable otk2 otk8 viable, with Scer\GAL4pnr-MD237 otkGD66 otkGD2562 otkGD14399 Other Phenotypes Allele wild-type otk2 otk8 Phenotype manifest in Allele abdominal segmental nerve otk1 otk3 abdominal segmental nerve, with Scer\GAL4elav.PLu otkEP2017 axon otk1 otk3 axon, with Scer\GAL4elav.PLu otkEP2017 eye photoreceptor cell & axon & larva | somatic clone otk3 intersegmental nerve otk1 otk3 intersegmental nerve, with Scer\GAL4elav.PLu otkEP2017 lamina & glial cell & larva | somatic clone otk3 medulla | somatic clone otk3 photoreceptor cell R1 & axon & larva | somatic clone otk3 photoreceptor cell R1 & axon | somatic clone otk3 photoreceptor cell R2 & axon & larva (with otk3), with Scer\GAL4[-]: otkEP2017 photoreceptor cell R2 & axon & larva (with otkEP2017), with Scer\GAL4[-]: otk3 photoreceptor cell R2 & axon & larva | somatic clone otk3 photoreceptor cell R2 & axon | somatic clone otk3 photoreceptor cell R3 & axon & larva (with otk3), with Scer\GAL4[-]: otkEP2017 photoreceptor cell R3 & axon & larva (with otkEP2017), with Scer\GAL4[-]: otk3 photoreceptor cell R3 & axon & larva | somatic clone otk3 photoreceptor cell R3 & axon | somatic clone otk3 photoreceptor cell R4 & axon & larva (with otk3), with Scer\GAL4[-]: otkEP2017 photoreceptor cell R4 & axon & larva (with otkEP2017), with Scer\GAL4[-]: otk3 photoreceptor cell R4 & axon & larva | somatic clone otk3 photoreceptor cell R4 & axon | somatic clone otk3 photoreceptor cell R5 & axon & larva (with otk3), with Scer\GAL4[-]: otkEP2017 photoreceptor cell R5 & axon & larva (with otkEP2017), with Scer\GAL4[-]: otk3 photoreceptor cell R5 & axon & larva | somatic clone otk3 photoreceptor cell R5 & axon | somatic clone otk3 photoreceptor cell R6 & axon & larva (with otk3), with Scer\GAL4[-]: otkEP2017 photoreceptor cell R6 & axon & larva (with otkEP2017), with Scer\GAL4[-]: otk3 photoreceptor cell R6 & axon & larva | somatic clone otk3 photoreceptor cell R6 & axon | somatic clone otk3
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of otk Class Mutagen Stocks Known lesion otkEP2017 P-element activity 2 Yes otkf00431 piggyBac transposase 1 -- otkMB06876 1 -- otk1 0 -- otk2 0 Yes otk3 loss of function allele 0 Yes otk8 0 Yes otkCPTI000252 piggyBac transposase 0 Yes
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of otk Class Mutagen Stocks Known lesion otkGD14399 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes otkGD2562 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes otkGD66 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes otkJF01796 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes otkKK103191 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes otkcPa in vitro construct 0 Yes otkHM05127 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes otkScer\UAS.cWa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD66} NA P{GD2562} NA P{GD14399} NA P{KK103191} NA P{TRiP.HM05127} NA P{TRiP.JF01796} NA P{UAS-otk.W} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}otkEP2017 NA miscellaneous insertions PBac{602.P.SVS-1}otkCPTI000252 NA PBac{WH}otkf00431 NA insertion of enhancer trap binary system Mi{ET1}otkMB06876 No
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function
CV term Evidence References
cell adhesion molecule binding inferred from direct assay AND inferred from sequence or structural similarity (Pulido et al., 1992) protein kinase activity inferred from direct assay (Pulido et al., 1992) receptor activity inferred from direct assay AND inferred from sequence or structural similarity (Pulido et al., 1992)
Biological Process
CV term Evidence References
axon guidance inferred from genetic interaction with Sema-1a AND inferred from genetic interaction with plexA AND inferred from mutant phenotype (Winberg et al., 2001) inferred from mutant phenotype (Cafferty et al., 2004) cell adhesion inferred from direct assay AND inferred from sequence or structural similarity (Pulido et al., 1992)
Cellular Component
CV term Evidence References
plasma membrane inferred from direct assay (Pulido et al., 1992)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719 (FlyBase Curators et al., 2004-) protein tyrosine kinase activity inferred from sequence or structural similarity with NCBI_gi:4506273 (FlyBase, 1992-) non-traceable author statement (Morrison et al., 2000) semaphorin receptor binding traceable author statement (Castellani and Rougon, 2002) transmembrane receptor protein tyrosine kinase activity inferred from sequence or structural similarity (Pulido et al., 1992)
Biological Process
CV term Evidence References
protein phosphorylation inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR001245, InterPro:IPR008266, InterPro:IPR020635 (FlyBase Curators et al., 2004-) non-traceable author statement (Morrison et al., 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions otk allele Gene References otk3 Sema-1a (Winberg et al., 2001) unspecified plexA (Winberg et al., 2001)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62067 DroID - A comprehensive database of gene and protein interactions. • FBgn0004839 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36283
Orthologs
Genome-wide drosophilid orthologs	Dana\GF12649 Dere\GG22613 Dgri\GH21048 Dmoj\GI18649 Dper\GL11545 Dpse\GA21443 Dsec\GM20393 Dsim\GD25868 Dvir\GJ21665 Dwil\GK21983 Dyak\GE13482
Curated drosophilid orthologs	Dpse\GA21443
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL007876-PA Aedes aegypti (mosquito) AGAP011489-PA Anopheles gambiae (mosquito) XP_394162.3 Apis mellifera (honey bee) ENSBTAP00000016963 Bos taurus (bovine) ENSCAFP00000002652 Canis familiaris (dog) ENSCPOP00000002759 Cavia porcellus (guinea pig) ENSCSAVP00000016252 Ciona savignyi (sedentary tunicate) 50189 Daphnia pulex (daphnia) ENSDARP00000089233 Danio rerio (zebra fish) ENSECAP00000009553 Equus caballus (horse) ENSGACP00000005294 Gymnopilus aculeatus (mushroom) ENSGALP00000014004 Gallus gallus (chicken) 106742 Hypsipyla robusta (cedar shoot borer) ENSP00000230419 Homo sapiens (human) ISCW015459-PA Ixodes scapularis (deer tick) 71201 Lottia gigantea (owl limpet) ENSMODP00000023690 Monodelphis domestica (gray opossum) ENSMMUP00000033655 Macaca mulatta (rhesus monkey) ENSMUSP00000043703 Mus musculus (house mouse) XP_001602704.1 Nasonia vitripennis (wasp) ENSORLP00000016294 Oryzias latipes (japanese killifish) PHUM004698-PA Pediculus humanus (human body louse) ENSPPYP00000018604 Pongo pygmaeus (orangutan) 77379 Phytophthora ramorum (sudden oak death pathogen) ENSPTRP00000031080 Pan troglodytes (chimpanzee) Smp_173380 Schistosoma mansoni (trematode parasite) XP_795531.2 Strongylocentrotus purpuratus (purple sea urchin) XP_972111.1 Tribolium castaneum (red flour beetle) ENSTNIP00000016415 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000044887 Takifugu rubripes (pufferfish Takifugu) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13609 NV16625 LH14768 ISCW015459 FBgn0231151 FBgn0223968 FBgn0208784 FBgn0197148 FBgn0175276 JGI_V11_33294 JGI_V11_50189 FBgn0081430 FBgn0149154 FBgn0149152 FBgn0141388 FBgn0128510 FBgn0114784 FBgn0089685 CPIJ006028 BGIBMGA000999 GB18159 AGAP011489 AAEL007876 PHUM363300 GLEAN_03353
Stocks & Reagents
Stocks Listed in FlyBase ( 12 )
Bloomington	25334 w1118; Mi{ET1}otkMB06876 17231 w1118; P{EP}otkEP2017/CyO 25790 y1 v1; P{TRiP.JF01796}attP2
Harvard	- PBac{WH}otkf00431
Kyoto	114461 yd2 w1118 P{ey-FLP.N}2; P{neoFRT}42D P{EP}otkEP2017 /CyO y+
VDRC	v104688 P{KK103191}VIE-260B v878 w1118; P{GD66}v878 v879 w1118; P{GD66}v879 v42565 w1118; P{GD2562}v42565 v42566 w1118; P{GD2562}v42566 v30833 w1118; P{GD14399}v30833 v30834 w1118; P{GD14399}v30834
Genomic Clones ( 2 )
	BACR04E21 BACR14L19 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 25 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LP17455
Other clones	RT02641
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH23842 LP21473
Other clones	17207 57559 99149 103560 145876 214411.26 214537.31 EC27129 EC33294 EC38829 EC053991 EC054489 EC054972 EK221760 EK248455 EP21032 RP003142534 RP003278414 RP003404352 RP003520603 RP003613493
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004839 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36283
Antibody Information
	polyclonal (Pulido et al., 1992, Peradziryi et al., 2011)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Phylogenetic analysis of the PTK family. (Suga et al., 1997) The otk gene product promotes cell adhesion in a homophilic calcium- dependent manner and this adhesion process specifically activates its kinase behaviour. (Pulido, 1993) Identification: By sequence similarity to human trk (receptor tyrosine kinase) cDNA probes. (Pulido et al., 1992) otk has been identified, sequence and its expression pattern characterised. (Pulido et al., 1992)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078981 RefSeq (Proteins) • NP_523705 DDBJ / EMBL / GenBank • AAF58596 AAT94478 AQ074029 BT015249 CAA45053 CQ847776 CZ482896 X63453 Entrez Gene - A searchable database of RefSeq genes. • 36283 UniProtKB/TrEMBL • Q6AWJ9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Immunoglobulin subtype 2 (IPR003598) Immunoglobulin subtype (IPR003599) Immunoglobulin-like (IPR007110) Tyrosine-protein kinase, active site (IPR008266) Protein kinase-like domain (IPR011009) Immunoglobulin-like fold (IPR013783) Tyrosine-protein kinase, catalytic domain (IPR020635) Serine-threonine/tyrosine-protein kinase (IPR001245) Immunoglobulin I-set (IPR013098)
Linkouts
	BioGRID - A database of protein and genetic interactions • 62067 DroID - A comprehensive database of gene and protein interactions. • FBgn0004839 DRSC - Results from RNAi screens. • FBgn0004839 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004839 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8967-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004839 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36283 InParanoid A subset of ortholog calls from InParanoid. • AAEL007876-PA Aedes aegypti (mosquito) AGAP011489-PA Anopheles gambiae (mosquito) XP_394162.3 Apis mellifera (honey bee) ENSBTAP00000016963 Bos taurus (bovine) ENSCAFP00000002652 Canis familiaris (dog) ENSCPOP00000002759 Cavia porcellus (guinea pig) ENSCSAVP00000016252 Ciona savignyi (sedentary tunicate) 50189 Daphnia pulex (daphnia) ENSDARP00000089233 Danio rerio (zebra fish) ENSECAP00000009553 Equus caballus (horse) ENSGACP00000005294 Gymnopilus aculeatus (mushroom) ENSGALP00000014004 Gallus gallus (chicken) 106742 Hypsipyla robusta (cedar shoot borer) ENSP00000230419 Homo sapiens (human) ISCW015459-PA Ixodes scapularis (deer tick) 71201 Lottia gigantea (owl limpet) ENSMODP00000023690 Monodelphis domestica (gray opossum) ENSMMUP00000033655 Macaca mulatta (rhesus monkey) ENSMUSP00000043703 Mus musculus (house mouse) XP_001602704.1 Nasonia vitripennis (wasp) ENSORLP00000016294 Oryzias latipes (japanese killifish) PHUM004698-PA Pediculus humanus (human body louse) ENSPPYP00000018604 Pongo pygmaeus (orangutan) 77379 Phytophthora ramorum (sudden oak death pathogen) ENSPTRP00000031080 Pan troglodytes (chimpanzee) Smp_173380 Schistosoma mansoni (trematode parasite) XP_795531.2 Strongylocentrotus purpuratus (purple sea urchin) XP_972111.1 Tribolium castaneum (red flour beetle) ENSTNIP00000016415 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000044887 Takifugu rubripes (pufferfish Takifugu) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /hjmuller/offtrack1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36283 modMine - Data generated by the modENCODE project. • FBgn0004839 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13609 NV16625 LH14768 ISCW015459 FBgn0231151 FBgn0223968 FBgn0208784 FBgn0197148 FBgn0175276 JGI_V11_33294 JGI_V11_50189 FBgn0081430 FBgn0149154 FBgn0149152 FBgn0141388 FBgn0128510 FBgn0114784 FBgn0089685 CPIJ006028 BGIBMGA000999 GB18159 AGAP011489 AAEL007876 PHUM363300 GLEAN_03353
Synonyms & Secondary IDs ( 17 )
Reported As
Symbol Synonym	anon-WO2004063362.81   CG8967 (Morrison et al., 2000, Perkins et al., 1.15.2009, Keleman et al., 2009.8.5, Perkins et al., 2009) CT25769 (Hynes and Zhao, 2000) Dtkr   Dtrk (Hidalgo, 2002, Jaaro et al., 2001, Goodman, 1999.8.19, Suga et al., 1997, Pulido, 1993, Pulido et al., 1991, Gomez-Skarmeta et al., 1993, Steller and Grether, 1994, Bieber, 1994, Perrimon, 1994, Pulido et al., 1992, Barbacid et al., 1991) dTrk (Castellani and Rougon, 2002) DTrk (Bai and Montell, 1999, Bai and Montell, 1998) IGGtyk   OFT/TRK (Morrison et al., 2000) OTK (Terman and Kolodkin, 2004) Otk (Cafferty et al., 2004, Minidorff et al., 2007) otk (Bakal et al., 2008, Zeitlinger et al., 2007) Tk48D   Trk48D
Name Synonym	Off-track (Terman and Kolodkin, 2004) off-track   Tyrosine kinase at 48D
Secondary FlyBase IDs
	FBgn0082205
References ( 54 )
Generate a list of	All references relating to this gene ( 54 )
List References by type	Research paper  ( 9 ) Supplementary material  ( 6 ) Review  ( 14 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 7 ) FlyBase analysis  ( 1 ) Patent  ( 1 ) Computer file  ( 4 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 1 )
	Peradziryi et al., 2011, EMBO J. 30(18): 3729--3740 PTK7/Otk interacts with Wnts and inhibits canonical Wnt signalling. [FBrf0215241] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...