AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.45
None of the polypeptides share 100% sequence identity.
The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ac76E using the Feature Mapper tool.
Ac76E is detected in all developmental stages by qRT-PCR and the level is three-fold higher in adult males relative to adult females. Expression is detected by in situ hybridization in embryos from stage 16 on in four tubule-like structures and in a spot in the hindgut region. In third instar larvae, Ac76E is detected in the gastric caecum, the corpus allatum, and in the lower ureter of the Malpighian tubules. Weak expression is also observed in imaginal discs and salivary glands. In adults, expression is seen in the corpus allatum and in the male reproductive system.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Ac76E in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.