FlyBase Gene Report: Dmel\Ac76E

General Information

Symbol

Dmel\Ac76E

Species

D. melanogaster

Name

Adenylyl cyclase 76E

Annotation Symbol

CG7978

Feature Type

protein_coding_gene

FlyBase ID

FBgn0004852

Gene Model Status

Current

Stock Availability

11 publicly available

Enzyme Name (EC)

adenylate cyclase (4.6.1.1)

Gene Summary

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (UniProt, Q9VW60)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

DAC76E

Key Links

Genomic Location

Cytogenetic map

76D6-76D7

Sequence location

3L:19,939,287..19,977,960 [+]

Recombination map

3-46

RefSeq locus

NT_037436 REGION:19939287..19977960

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables adenylate cyclase activity

inferred from direct assay

(Mattila et al., 2009)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables adenylate cyclase activity

inferred from biological aspect of ancestor with PANTHER:PTN002899368

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR030672

(InterPro Project Members, 2004-)

enables phosphorus-oxygen lyase activity

inferred from electronic annotation with InterPro:IPR018297

(InterPro Project Members, 2004-)

Biological Process (7 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in instar larval or pupal development

inferred from mutant phenotype

(Mattila et al., 2009)

involved_in negative regulation of multicellular organism growth

inferred from mutant phenotype

(Mattila et al., 2009)

involved_in response to starvation

inferred from direct assay

(Mattila et al., 2009)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN002899368

(GO Reference Genome Project, 2011-)

involved_in cAMP biosynthetic process

inferred from electronic annotation with InterPro:IPR030672

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000229373

(GO Reference Genome Project, 2011-)

involved_in cyclic nucleotide biosynthetic process

inferred from electronic annotation with InterPro:IPR001054, InterPro:IPR018297

(InterPro Project Members, 2004-)

involved_in intracellular signal transduction

inferred from electronic annotation with InterPro:IPR001054, InterPro:IPR018297

(InterPro Project Members, 2004-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN002899368

(GO Reference Genome Project, 2011-)

located_in plasma membrane

inferred from electronic annotation with InterPro:IPR030672

(InterPro Project Members, 2004-)

Gene Group (FlyBase)

ADENYLATE CYCLASES

Protein Family (UniProt)

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (Q9VW60)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

adenylate cyclase activity

ATP = 3',5'-cyclic AMP + diphosphate (4.6.1.1)

RHEA 15389:

Summaries

Gene Group (FlyBase)

ADENYLATE CYCLASES -: Adenylate cyclases catalyze the synthesis of cAMP from ATP, yielding diphosphate as a by-product. (Adapted from FBrf0238856).

Protein Function (UniProtKB)

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.

(UniProt, Q9VW60)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Ac76E for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VW60)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Ac76E-RA

FBtr0074897

NM_079449

5305

1307

Ac76E-RB

FBtr0304746

NM_001259909

5320

1312

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Ac76E-PA

FBpp0074666

142.8

1307

6.04

FBpp0293288

143.4

1312

6.10

M9NDD2

NP_001246838

AFH04509

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Domain

The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.

(UniProt, Q9VW60)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ac76E using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ac76E_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.03

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 16 -- 17

embryonic/larval hindgut | restricted

(Mattila et al., 2009)

third instar larval stage

embryonic/larval corpus allatum

(Mattila et al., 2009)

gastric caecum

(Mattila et al., 2009)

embryonic/larval ureter

(Mattila et al., 2009)

imaginal disc

(Mattila et al., 2009)

embryonic/larval salivary gland

(Mattila et al., 2009)

adult stage | male

adult corpus allatum

(Mattila et al., 2009)

male reproductive system

(Mattila et al., 2009)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Mattila et al., 2009)

Additional Descriptive Data

Ac76E is detected in all developmental stages by qRT-PCR and the level is three-fold higher in adult males relative to adult females. Expression is detected by in situ hybridization in embryos from stage 16 on in four tubule-like structures and in a spot in the hindgut region. In third instar larvae, Ac76E is detected in the gastric caecum, the corpus allatum, and in the lower ureter of the Malpighian tubules. Weak expression is also observed in imaginal discs and salivary glands. In adults, expression is seen in the corpus allatum and in the male reproductive system.

(Mattila et al., 2009)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 5 of adulthood & male -- day 7 of adulthood & male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Ac76E in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Ac76E

View exonic expression by tissue for Dmel\Ac76E

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40180/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0004852

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004852

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0004852

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7978

Flygut - An atlas of the Drosophila adult midgut

FBgn0004852

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 7 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Ac76E

Transgenic constructs containing regulatory region of Ac76E

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Ac76E^GD2737

viable, with Scer\GAL4^tin.CΔ4

Ac76E^GD2737

Other Phenotypes

Allele

abnormal body size | adult stage, with Scer\GAL4^Hmgcr.B

Ac76E^UAS.Tag:HA

abnormal body size | wandering third instar larval stage, with Scer\GAL4^Hmgcr.B

Ac76E^UAS.Tag:HA

abnormal developmental rate, with Scer\GAL4^Hmgcr.B

Ac76E^UAS.Tag:HA

abnormal starvation stress response | female limited, with Scer\GAL4^Hmgcr.B

Ac76E^UAS.Tag:HA

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (23)

Hsap\ADCY2

11 of 14

Yes

Hsap\ADCY4

10 of 14

Yes

Hsap\ADCY7

9 of 14

Yes

5 of 14

5 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (23)

Rnor\Adcy2

11 of 14

Yes

Rnor\Adcy4

10 of 14

Yes

Rnor\Adcy7

10 of 14

Yes

5 of 14

4 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (24)

Mmus\Adcy2

11 of 14

Yes

Mmus\Adcy4

10 of 14

Yes

Mmus\Adcy7

9 of 14

Yes

5 of 14

5 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (11)

Xtro\adcy7

9 of 13

Yes

Xtro\adcy4

8 of 13

Yes

Xtro\adcy1

1 of 13

Xtro\adcy6

1 of 13

Xtro\avp

1 of 13

Yes

Xtro\grn

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (31)

Drer\adcy2a

11 of 14

Yes

Drer\adcy2b

11 of 14

Yes

Drer\adcy7

10 of 14

Yes

5 of 14

5 of 14

5 of 14

3 of 14

3 of 14

3 of 14

Drer\si:ch211-132f19.7

3 of 14

Drer\si:dkey-206f10.1

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (38)

Cele\acy-2

9 of 14

Yes

4 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (25)

Agam\AgaP_AGAP010436

12 of 12

Yes

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\CYR1

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\cyr1

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Ac76E. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (27)

Ac3

6 of 13

6 of 13

6 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

4 of 13

4 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ADCY2; adenylate cyclase 2

11 of 14

103071

ADCY4; adenylate cyclase 4

10 of 14

600292

ADCY7; adenylate cyclase 7

9 of 14

600385

ADCY5; adenylate cyclase 5

5 of 14

600293

ADCY6; adenylate cyclase 6

5 of 14

600294

LETHAL CONGENITAL CONTRACTURE SYNDROME 8; LCCS8

ADCY1; adenylate cyclase 1

3 of 14

103072

DEAFNESS, AUTOSOMAL RECESSIVE 44; DFNB44

autosomal recessive nonsyndromic deafness 44

ADCY3; adenylate cyclase 3

3 of 14

600291

BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 19; BMIQ19

ADCY8; adenylate cyclase 8

3 of 14

103070

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0004852

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-46

Cytogenetic map

76D6-76D7

Sequence location

3L:19,939,287..19,977,960 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

76D6-76D7

Limits computationally determined from genome sequence between P{lacW}l(3)L1243^L1243&P{lacW}Mi-2^j3D4 and P{PZ}eRF1⁰⁰¹⁰³

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

76E-76E

(Chung, 1998.9.21)

Experimentally Determined Recombination Data

Location

3-46

(FlyBase, 2016)

3-43.5

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (11)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

68217

w^*; P{UAS-Ac76E.D}2

37548

y¹ w^*; Mi{MIC}Ac76E^MI00926

23326

y¹ w^67c23; Mi{ET1}Ac76E^MB01510

30649

y¹ w^*; Mi{MIC}Ac76E^MI00178/TM6B, Tb¹

59400

y¹ w^*; Mi{PT-GFSTF.1}Ac76E^{MI00178-GFSTF.1}/TM6C, Sb¹ Tb¹

66822

y¹ w^*; Mi{Trojan-GAL4.1}Ac76E^{MI00178-TG4.1}/TM3, Sb¹ Ser¹

7978R-1

7978R-3

v106232

v51974

w¹¹¹⁸ P{GD2737}v51974

v51975

w¹¹¹⁸; P{GD2737}v51975

Genomic Clones (26)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (32)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH26260

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0004852

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0004852

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

AC 76E

(Morrison et al., 2000)

AC76E

(Duvall and Taghert, 2013, Duvall and Taghert, 2012, Ueno and Kidokoro, 2008)

Ac76E

(Meyer et al., 2024, Corthals et al., 2023, Noyes and Davis, 2023, Pang et al., 2021, Gene Disruption Project members, 2016-, Calap-Quintana et al., 2015, Gene Disruption Project members, 2015-, Nagarkar-Jaiswal et al., 2015, Ashwal-Fluss et al., 2014, Liang et al., 2014, Sen et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Wasbrough et al., 2010)

CG7978

(Keleman et al., 2009.8.5, Morrison et al., 2000)

DAC2

(Levin, 1997.12.23)

DAC76E

(Cann and Levin, 2000, Cann et al., 2000, Iourgenko and Levin, 2000)

ac76e

(Naganos et al., 2016, Mattila et al., 2009)

dADCY2

(Yoon et al., 2022)

Name Synonyms

AdenylateCyclase E

(Zhan et al., 2013)

Adenylyl cyclase 76E

adenylyl cyclase

(Yovell et al., 1992)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 49 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40180

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VW60

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VW60

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

M9NDD2

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VW60

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40180/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0004852

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0004852

FlyMine - An integrated database for Drosophila genomics

FBgn0004852

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG7978

MARRVEL_MODEL - MARRVEL (model organism gene)

40180

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0004852

DroID - A comprehensive database of gene and protein interactions.

FBgn0004852

DRSC - Results frm RNAi screens

FBgn0004852

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ac76E_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004852

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0004852

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7978

Flygut - An atlas of the Drosophila adult midgut

FBgn0004852

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0004852

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC032331

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (59)

The following external sites may use different assemblies or annotations than FlyBase.

-1.03

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