• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\elB

General Information
Symbol	Dmel\elB	Species	D. melanogaster
Name	elbow B	Annotation symbol	CG4220
Feature type	protein_coding_gene	FlyBase ID	FBgn0004858
Gene Model Status	Current	Stock availability	15 publicly available
Also Known As	el, elbow, BG:DS06238.3
Genomic Location
Chromosome (arm)	2L	Recombination map	2-50.0
Cytogenetic map	35B1-35B1	Sequence location	2L:14,390,628..14,409,549 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene elbow B is referred to in FlyBase by the symbol Dmel\elB (CG4220, FBgn0004858). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: wing disc development; eye-antennal disc development; cell proliferation; imaginal disc-derived appendage development; negative regulation of gene expression; Notch signaling pathway; open tracheal system development. 40 alleles are reported. The phenotypes of these alleles are annotated with: adult segment; organ system subdivision; late extended germ band embryo; thoracic segment; tracheal branch primordium; adult; organ system; non-connected developing system; dorsal ectoderm derivative; dorsal branch primordium; external compound sense organ. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Zinc finger C2H2-type/integrase DNA-binding domain; Zinc finger, C2H2; Zinc finger, C2H2-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, adult hindgut, larval/adult salivary gland, larval trachea, adult male accessory gland. Gene sequence location is 2L:14390625..14409547.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03	Polypeptides elB-PD Transcripts elB-RD
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 35B1-35B1   Limits computationally determined from genome sequence between P{lacW}l(2)34Fak00811&P{PZ}wb09437 and P{EP}elBEP2039&P{PZ}osprJ571
Experimentally Determined Cytological Location
Cytogenetic map Notes References 35B1-35B2   (determined by in situ hybridisation)   (Ashburner et al., 1999) 35B1-35B2   (determined by in situ hybridisation)   (Spradling et al., 1999)
Experimentally Determined Recombination Data
Location	2-50.0 (Ashburner, 1992)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\elB for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.51
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) elB-RC FBtr0080637  NM_205990   3323   552 elB-RD FBtr0342915     3326   553
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein elB-PC   FBpp0089383   55.7   552   9.23     NP_995712   AAS64707 elB-PD   FBpp0309706   55.9   553   9.23
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2 (IPR007087) Zinc finger, C2H2-like (IPR015880) Zinc finger C2H2-type/integrase DNA-binding domain (IPR013087)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAS64707   AE003409 AAF44874   AQ025002   AQ025843   AQ074050   AY115567 AAM48283   BI231440   BI484595   BI486943   BT001713 AAN71468   CO179432   CO186685   CO190512   CO262604   CO263810   CO267110   CO267140   CO270043   CO279597   CO279894   CO291376   CO293161   CO296689   CO297469   CO306822   CO307626   CO309358   CO310834   CO313247   CO329502   CO340381   CO341301   CZ466581   CZ467543   CZ483770   CZ483771   DN154254   EC064314   EC072283   EC075204   EC076245   EC080861   EC088982   EC196541   EC198376   EC201335   EC206124   EC206529   EC212112   EC221813   EC223701   EC224899   EC224930   EC231776   EC232770   EC233908   EC236656   EC242379   EC244795   EC247422   EC247799   EC252067   EC252165   EC252256   EC257651
UniProtKB/Swiss-Prot	Q9VJS8
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References regulatory region FBsf0000436237 2L:14,402,991..14,404,898 evidence=Reporter construct (in vivo) (Weiss et al., 2010, Halfon, 2012.6.19)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   dorsal head epidermis primordium   (Fisher et al., 2012) embryonic stage 11   tracheal pit   (Dorfman et al., 2002) embryonic stage 11 -- 12   central brain primordium   (Fisher et al., 2012) dorsal epidermis primordium   (Fisher et al., 2012) dorsal head epidermis primordium   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) posterior spiracle primordium   (Fisher et al., 2012) Comment:reported as posterior spiracle specific anlage tracheal primordium   (Fisher et al., 2012) embryonic stage 12   embryonic/larval dorsal branch   (Dorfman et al., 2002) embryonic stage 12 -- 13   embryonic/larval lateral trunk   (Dorfman et al., 2002) embryonic stage 13 -- 16   dorsal pharyngeal muscle   (Fisher et al., 2012) embryonic brain   (Fisher et al., 2012) embryonic dorsal epidermis   (Fisher et al., 2012) embryonic foregut   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval posterior spiracle   (Fisher et al., 2012) embryonic/larval visceral muscle   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nucleus inferred from direct assay (Dorfman et al., 2002)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, adult hindgut, larval/adult salivary gland, larval trachea, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    9 central nervous system, pupae P8    7 head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    9 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    3 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    3 carcass, larvae L3 wandering    7 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    1 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    9 central nervous system, pupae P8    7 head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    9 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    3 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    3 carcass, larvae L3 wandering    7 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    1 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    9 central nervous system, pupae P8    7 head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    9 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    3 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    3 carcass, larvae L3 wandering    7 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    1 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    9 central nervous system, pupae P8    7 head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    9 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    3 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    3 carcass, larvae L3 wandering    7 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    1 accessory gland, mated 4-day male    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    9 central nervous system, pupae P8    7 head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    9 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    3 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    3 carcass, larvae L3 wandering    7 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    1 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    9 central nervous system, pupae P8    7 head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    9 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    3 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    3 carcass, larvae L3 wandering    7 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    1 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    9 central nervous system, pupae P8    7 head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    9 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    3 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    3 carcass, larvae L3 wandering    7 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    1 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    9 central nervous system, pupae P8    7 head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    9 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    3 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    3 carcass, larvae L3 wandering    7 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    1 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    5 embryo 08-10hr    7 embryo 10-12hr    12 embryo 12-14hr    13 embryo 14-16hr    20 embryo 16-18hr    22 embryo 18-20hr    24 embryo 20-22hr    17 embryo 22-24hr    15 larva L1    10 larva L2    6 larva L3 12hr old    7 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    8 white prepupae 24hr    9 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    7 adult male 30day    6 adult female 01day    4 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    5 embryo 08-10hr    7 embryo 10-12hr    12 embryo 12-14hr    13 embryo 14-16hr    20 embryo 16-18hr    22 embryo 18-20hr    24 embryo 20-22hr    17 embryo 22-24hr    15 larva L1    10 larva L2    6 larva L3 12hr old    7 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    8 white prepupae 24hr    9 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    7 adult male 30day    6 adult female 01day    4 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    5 embryo 08-10hr    7 embryo 10-12hr    12 embryo 12-14hr    13 embryo 14-16hr    20 embryo 16-18hr    22 embryo 18-20hr    24 embryo 20-22hr    17 embryo 22-24hr    15 larva L1    10 larva L2    6 larva L3 12hr old    7 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    8 white prepupae 24hr    9 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    7 adult male 30day    6 adult female 01day    4 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    5 embryo 08-10hr    7 embryo 10-12hr    12 embryo 12-14hr    13 embryo 14-16hr    20 embryo 16-18hr    22 embryo 18-20hr    24 embryo 20-22hr    17 embryo 22-24hr    15 larva L1    10 larva L2    6 larva L3 12hr old    7 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    8 white prepupae 24hr    9 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    7 adult male 30day    6 adult female 01day    4 adult female 05day    2 adult female 30day    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    5 embryo 08-10hr    7 embryo 10-12hr    12 embryo 12-14hr    13 embryo 14-16hr    20 embryo 16-18hr    22 embryo 18-20hr    24 embryo 20-22hr    17 embryo 22-24hr    15 larva L1    10 larva L2    6 larva L3 12hr old    7 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    8 white prepupae 24hr    9 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    7 adult male 30day    6 adult female 01day    4 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    5 embryo 08-10hr    7 embryo 10-12hr    12 embryo 12-14hr    13 embryo 14-16hr    20 embryo 16-18hr    22 embryo 18-20hr    24 embryo 20-22hr    17 embryo 22-24hr    15 larva L1    10 larva L2    6 larva L3 12hr old    7 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    8 white prepupae 24hr    9 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    7 adult male 30day    6 adult female 01day    4 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    5 embryo 08-10hr    7 embryo 10-12hr    12 embryo 12-14hr    13 embryo 14-16hr    20 embryo 16-18hr    22 embryo 18-20hr    24 embryo 20-22hr    17 embryo 22-24hr    15 larva L1    10 larva L2    6 larva L3 12hr old    7 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    8 white prepupae 24hr    9 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    7 adult male 30day    6 adult female 01day    4 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    5 embryo 08-10hr    7 embryo 10-12hr    12 embryo 12-14hr    13 embryo 14-16hr    20 embryo 16-18hr    22 embryo 18-20hr    24 embryo 20-22hr    17 embryo 22-24hr    15 larva L1    10 larva L2    6 larva L3 12hr old    7 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    8 white prepupae 24hr    9 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    7 adult male 30day    6 adult female 01day    4 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    10 embryonic 1182-4H    0 embryonic GM2    3 embryonic Kc167    1 embryonic S1    1 embryonic S3    0 leg disc CME L1    6 wing disc CME-W2    0 wing disc ML-DmD8    9 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    0 ovary fGS/OSS    19 ovary OSC    20 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    10 embryonic 1182-4H    0 embryonic GM2    3 embryonic Kc167    1 embryonic S1    1 embryonic S3    0 leg disc CME L1    6 wing disc CME-W2    0 wing disc ML-DmD8    9 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    0 ovary fGS/OSS    19 ovary OSC    20 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    10 embryonic 1182-4H    0 embryonic GM2    3 embryonic Kc167    1 embryonic S1    1 embryonic S3    0 leg disc CME L1    6 wing disc CME-W2    0 wing disc ML-DmD8    9 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    0 ovary fGS/OSS    19 ovary OSC    20 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    10 embryonic 1182-4H    0 embryonic GM2    3 embryonic Kc167    1 embryonic S1    1 embryonic S3    0 leg disc CME L1    6 wing disc CME-W2    0 wing disc ML-DmD8    9 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    0 ovary fGS/OSS    19 ovary OSC    20 ovary OSS    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    10 embryonic 1182-4H    0 embryonic GM2    3 embryonic Kc167    1 embryonic S1    1 embryonic S3    0 leg disc CME L1    6 wing disc CME-W2    0 wing disc ML-DmD8    9 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    0 ovary fGS/OSS    19 ovary OSC    20 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    10 embryonic 1182-4H    0 embryonic GM2    3 embryonic Kc167    1 embryonic S1    1 embryonic S3    0 leg disc CME L1    6 wing disc CME-W2    0 wing disc ML-DmD8    9 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    0 ovary fGS/OSS    19 ovary OSC    20 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    10 embryonic 1182-4H    0 embryonic GM2    3 embryonic Kc167    1 embryonic S1    1 embryonic S3    0 leg disc CME L1    6 wing disc CME-W2    0 wing disc ML-DmD8    9 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    0 ovary fGS/OSS    19 ovary OSC    20 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    10 embryonic 1182-4H    0 embryonic GM2    3 embryonic Kc167    1 embryonic S1    1 embryonic S3    0 leg disc CME L1    6 wing disc CME-W2    0 wing disc ML-DmD8    9 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    0 ovary fGS/OSS    19 ovary OSC    20 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_29 mE1_20_mRNA_expression_cluster_14
External Data & Images
Linkouts	BDGP expression data • RE67722 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004858 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4220-RA;CG4220-RA;CG4220-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal elBd47 lethal, with Scer\GAL4btl.PS elBEP2039 lethal, with Scer\GAL4en-e16E elBEP2039 lethal (with Df(2L)A400) elB2 lethal (with Df(2L)el28) elB2 lethal (with Df(2L)TE35B-1) elB2 lethal (with Df(2L)TE35B-6) elB2 lethal (with Df(2L)TE35B-7) elB2 lethal (with Df(2L)TE35BC-8) elB2 lethal (with In(2L)TE35B-13) elB2 lethal | pupal stage, with Scer\GAL4pnr-MD237 elBGD1143 viable elB3.3.1 elBc01007 viable, with Scer\GAL4[-]: elBEP2039 viable | poor elB2 Sterility Allele fertile elBc01007 Other Phenotypes Allele visible elB2 visible, with Scer\GAL4ap-md544 elBEP965 visible, with Scer\GAL4en-e16E elBEP965 visible, with Scer\GAL4ey.PH elBEP965 elBEP2039 visible, with Scer\GAL4sca-537.4 elBEP965 visible | heat sensitive elB3 visible | recessive elB4 elB5 elB6 elB7 elB9 visible | recessive, with Scer\GAL4[-]: elBEP2039 Phenotype manifest in Allele 2nd posterior cell elB9 adult thorax, with Scer\GAL4ap-md544 elBEP965 alula elB4 elB6 alula & macrochaeta elB5 elB7 elB9 dorsal branch primordium elBd47 dorsal branch primordium, with Scer\GAL4btl.PS elBEP2039 elBScer\UAS.cDa dorsocentral bristle, with Scer\GAL4ap-md544 elBEP965 dorsocentral bristle | ectopic, with Scer\GAL4sca-537.4 elBEP965 dorsocentral bristle | supernumerary, with Scer\GAL4ap-md544 elBEP965 eye, with Scer\GAL4ey.PH elBEP2039 elBEP965 ganglionic branch primordium elBd47 lateral trunk anterior branch elBd47 scutellar bristle, with Scer\GAL4ap-md544 elBEP965 scutellar bristle | ectopic, with Scer\GAL4sca-537.4 elBEP965 scutellar bristle | supernumerary, with Scer\GAL4ap-md544 elBEP965 transverse connective primordium elBd47 transverse connective primordium, with Scer\GAL4btl.PS elBEP2039 visceral branch primordium, with Scer\GAL4btl.PS elBEP2039 elBScer\UAS.cDa wing elB4 elB6 wing | posterior elB5 elB7 elB9 wing vein, with Scer\GAL4en-e16E elBEP965 wing vein L5 elB5 elB7 elB9
Classical Alleles ( 35 )
For All Classical Alleles Show
Allele of elB Class Mutagen Stocks Known lesion elB9 gamma ray X ray 2 Yes elBc01007 piggyBac transposase 2 -- elB3 ethyl methanesulfonate 1 -- elB6 ethyl methanesulfonate X ray 1 Yes elBc00589 piggyBac transposase 1 -- elBc03049 1 -- elBf01298 piggyBac transposase 1 -- elBf05651a 1 -- elBf05651b 1 -- elBMI03746 1 -- elBd47 amorphic allele - genetic evidence Delta2-3 0 Yes elB10 gamma ray 0 -- elB11 gamma ray 0 -- elB12 gamma ray 0 -- elB13 gamma ray 0 -- elB21 ethyl methanesulfonate 0 -- elB22 ethyl methanesulfonate 0 -- elB23 ethyl methanesulfonate 0 -- elB25 ethyl methanesulfonate 0 -- elB26 ethyl methanesulfonate 0 -- elB27 ethyl methanesulfonate 0 -- elB29 gamma ray 0 -- elB2 ethyl methanesulfonate 0 -- elB3.3.1 ethyl methanesulfonate 0 Yes elB30 ethyl methanesulfonate 0 -- elB4 ethyl methanesulfonate X ray 0 Yes elB5 gamma ray X ray 0 Yes elB7 gamma ray X ray 0 Yes elB8 gamma ray 0 -- elBc01895 piggyBac transposase 0 -- elBel-1 0 -- elBEP2039 hypomorphic allele - genetic evidence P-element activity 0 Yes elBEP965 P-element activity 0 Yes elBGAL4 0 Yes elBk07706 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of elB Class Mutagen Stocks Known lesion elBGD1143 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes elBHMS02357 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes elBKK111245 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes elBdsRNA.cTa in vitro construct - RNAi 0 Yes elBScer\UAS.cDa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)A47 (Fossett et al., 1994, Roote et al., 1996) Df(2L)A215 (Fossett et al., 1994) Df(2L)A217 (Roote, 1998.11.16, Fossett et al., 1994) Df(2L)A246 (Fossett et al., 1994) Df(2L)A337 (Fossett et al., 1994) Df(2L)A376 (Fossett et al., 1994) Df(2L)A400 (Davis et al., 1990, Fossett et al., 1994, Roote et al., 1996, Davis et al., 1997) Df(2L)Adh-nBR100 (Fossett et al., 1994) Df(2L)Adh-nBR101 (Fossett et al., 1994) Df(2L)Adh-nBR103 (Fossett et al., 1994) Df(2L)Adh-nBR117 (Fossett et al., 1994) Df(2L)Adh-nBR120 (Fossett et al., 1994) Df(2L)Adh-nBR125 (Fossett et al., 1994) Df(2L)Adh-nBR130 (Fossett et al., 1994) Df(2L)Adh-nBR131 (Fossett et al., 1994) Df(2L)b81a1 (Roote et al., 1996) Df(2L)b83d29a (Davis et al., 1990, Roote et al., 1996, Davis et al., 1997) Df(2L)b84a2 (Davis et al., 1990, Roote et al., 1996, Davis et al., 1997) Df(2L)b84a4 (Roote et al., 1996) Df(2L)b88h49 (Roote et al., 1996, Roote, 1996.8) Df(2L)el16 (Davis et al., 1990) Df(2L)el94 (Roote, 1996.1.11, Roote, 1996.8) Df(2L)EP(2)2039-rv3 (Roote, 2000.6.13) Df(2L)EP(2)2039-rv4 (Roote, 2000.6.13) Df(2L)Exel6035 (Ryder, 2004.4.26) Df(2L)fn1 (Grau et al., 1984) Df(2L)fn2 (Dorfman et al., 2002) Df(2L)noc10 (Dorfman et al., 2002) Df(2L)ppkESB (Boiko et al., 2012) Df(2L)Scorv23 (Grau et al., 1984) Df(2L)TE35B-1 (Gubb et al., 1985) Df(2L)TE35B-2 (Gubb et al., 1985) Df(2L)TE35B-3 (Gubb et al., 1985) Df(2L)TE35B-4 (Gubb et al., 1985) Df(2L)TE35B-5 (Gubb et al., 1985) Df(2L)TE35B-6 (Gubb et al., 1985) Df(2L)TE35B-7 (Gubb et al., 1985, Davis et al., 1990, Roote et al., 1996, Davis et al., 1997) Df(2L)TE35B-8 (Gubb et al., 1985, Roote et al., 1996) Df(2L)TE35B-9 (Gubb et al., 1985) Df(2L)TE35B-10 (Gubb et al., 1985) Df(2L)TE35B-12 (Gubb et al., 1985) Df(2L)TE35B-15 (Gubb et al., 1985) Df(2L)TE35B-300 (Roote et al., 1996) In(2L)75c (Grau et al., 1984) In(2L)el94 (Roote, 1998.3.17) In(2L)el9 (Davis et al., 1990, Roote et al., 1996, Davis et al., 1997) In(2L)TE35B-13 (Gubb et al., 1985, Roote et al., 1996, Roote, 1996.8, Davis et al., 1997) In(2LR)D20Lnoc4R (Roote et al., 1996) In(2LR)el6 (Davis et al., 1990, Davis et al., 1997) In(2LR)el6LA379R (Roote, 1996.1.11) T(2;3)dpps19 (Davis et al., 1990, Roote et al., 1996, Davis et al., 1997) T(Y;2)a15 (Davis et al., 1990, Roote et al., 1996, Davis et al., 1997) T(Y;2)el4 (Davis et al., 1990, Roote et al., 1996, Davis et al., 1997) T(Y;2)GT2 (Davis et al., 1990) Ts(2Lt;3Lt)dpps19+Ts(2Rt;3Rt)el24 (Roote, 1995.3.27, Roote, 1996.1.11, Roote et al., 1996) Ts(2Lt;3Rt)GT10+Ts(2Rt;3Lt)TE35B-209 (Roote et al., 1996) Ts(Y;2Lt)a15+Ts(YSt;2Rt)A80 (Roote, 1995.3.27, Roote, 1996.1.11, Roote et al., 1996) Ts(Y;2Lt)el4+Ts(YSt;2Rt)A80 (Roote, 1996.1.11, Roote et al., 1996) Ts(Y;2Lt)el4+Ts(YSt;2Rt)R15 (Roote, 1996.1.11, Roote et al., 1996) Ts(Y;2Lt)GT2+Ts(YSt;2Rt)A80 (Roote, 1996.1.11, Roote et al., 1996, Roote, 1996.8, Davis et al., 1997)
Not disrupted in	Df(2L)A48 (Grau et al., 1984, BDGP Project Members, 1994-1999, Fossett et al., 1994, Roote et al., 1996) Df(2L)A63 (Fossett et al., 1994, Roote et al., 1996) Df(2L)A72 (Fossett et al., 1994) Df(2L)A178 (Fossett et al., 1994, Roote et al., 1996, Davis et al., 1997) Df(2L)A220 (Fossett et al., 1994) Df(2L)A245 (Davis et al., 1990, Fossett et al., 1994, Roote et al., 1996) Df(2L)A260 (Davis et al., 1990) Df(2L)A264 (Fossett et al., 1994) Df(2L)A266 (Davis et al., 1990, Fossett et al., 1994) Df(2L)A267 (Fossett et al., 1994, Roote et al., 1996) Df(2L)A379 (Fossett et al., 1994) Df(2L)A445 (Fossett et al., 1994, Roote et al., 1996) Df(2L)Adh-nBR102 (Fossett et al., 1994, Roote et al., 1996) Df(2L)Adh-nBR105 (Fossett et al., 1994) Df(2L)Adh-nBR106 (Fossett et al., 1994) Df(2L)Adh-nBR107 (Fossett et al., 1994) Df(2L)Adh-nBR118 (Fossett et al., 1994) Df(2L)Adh-nBR119 (Fossett et al., 1994) Df(2L)Adh-nBR121 (Fossett et al., 1994) Df(2L)Adh-nBR122 (Fossett et al., 1994) Df(2L)Adh-nBR126 (Fossett et al., 1994) Df(2L)Adh-nBR127 (Fossett et al., 1994) Df(2L)Adh-nBR128 (Fossett et al., 1994) Df(2L)Adh-nBR129 (Fossett et al., 1994) Df(2L)ARR1 (Davis et al., 1990, Roote et al., 1996) Df(2L)b80e3 (Roote et al., 1996) Df(2L)ED3 (Roote, 2002.2.6, Ryder and Roote, 2004.11.10) Df(2L)el14 (Roote et al., 1996, Davis et al., 1997) Df(2L)el16 (Davis et al., 1997) Df(2L)el28 (Davis et al., 1990, Davis et al., 1997) Df(2L)fn2 (Roote et al., 1996, Davis et al., 1997) Df(2L)fn3 (Davis et al., 1990, Davis et al., 1997) Df(2L)fn27 (Davis et al., 1997) Df(2L)n78l3 (Davis et al., 1997) Df(2L)osp29 (Grau et al., 1984, Roote et al., 1996) Df(2L)osp144 (Roote et al., 1996) Df(2L)ppkESB (Boiko et al., 2012) Df(2L)Scorv10 (Grau et al., 1984) Df(2L)Scorv16 (Grau et al., 1984) Df(2L)Scorv19 (Grau et al., 1984) Df(2L)Scorv25 (Grau et al., 1984) Df(2L)SS1 (Grau et al., 1984) Df(2L)TE35B-1 (Davis et al., 1990, Davis et al., 1997) Df(2L)TE35B-6 (Davis et al., 1990, Davis et al., 1997) Df(2L)TE35B-11 (Gubb et al., 1985, Roote et al., 1996) Df(2L)TE35B-12 (Roote et al., 1996, Roote, 1996.8) Df(2L)TE35B-54L (Roote et al., 1996) Df(2L)TE35BC-3 (Grau et al., 1984) Df(2L)TE35BC-4 (Roote et al., 1996) Df(2L)TE35BC-8 (Davis et al., 1990, Davis et al., 1997) Dp(2;2)Cam12 (Roote et al., 1996) In(2L)75c (BDGP Project Members, 1994-1999) In(2LR)DTD128 (Davis et al., 1990) In(2LR)el6LA379R (Roote et al., 1996) T(2;3)el24 (Davis et al., 1990) T(2;3)GT8 (Davis et al., 1990) T(2;3)GT10 (Davis et al., 1990) T(2;3)Scorv7 (Grau et al., 1984) T(Y;2)A80 (Davis et al., 1990) T(Y;2)GT2 (Roote et al., 1996) Tp(2;2)A446 (Fossett et al., 1994, Roote et al., 1996, Davis et al., 1997) Tp(2;3)GT3 (Davis et al., 1990, Roote et al., 1996) Ts(2Lt;3Lt)TE35B-28+Ts(2Rt;3Rt)osp90 (Roote et al., 1996) Ts(Y;2Lt)TE35B-18+Ts(YSt;2Rt)R15 (Davis et al., 1990)
Duplicated in	Dp(2;1)Scorv23 (Grau et al., 1984) Ts(2Lt;4Lt)TE35B-101+Ts(2Rt;4Rt)GT6 (Roote et al., 1996) Ts(YLt;2Lt)A80+Ts(YLt;2Rt)G74 (Roote et al., 1996)
Not duplicated in	Dp(2;2)TE35B-54L (Roote et al., 1996) Dp(2;3)osp3 (Roote et al., 1996) In(2L)C163.41LC158R (Roote et al., 1996) In(2LR)TE35B-226LDTD128R (Roote et al., 1996) Ts(Y;2Lt)TE35B-18+Ts(YSt;2Rt)A80 (Roote et al., 1996) Ts(YLt;2Lt)R15+Ts(Y;2Rt)TE35B-18 (Roote et al., 1996) Ts(YLt;2Lt)R15+Ts(YSt;2Rt)A80 (Roote et al., 1996)
Partially disrupted in	In(2LR)el6LA379R (Roote, 1996.8) Ts(2Lt;3Lt)dpps19+Ts(2Rt;3Rt)el24 (Roote, 1996.8) Ts(Y;2Lt)a15+Ts(YSt;2Rt)A80 (Roote, 1996.8) Ts(Y;2Lt)el4+Ts(YSt;2Rt)A80 (Roote, 1996.8) Ts(Y;2Lt)el4+Ts(YSt;2Rt)R15 (Roote, 1996.8)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1143} NA P{KK111245} NA P{TRiP.HMS02357} NA P{UAS-elB.D} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}elBEP965 NA P{EP}elBEP2039 NA miscellaneous insertions Mi{MIC}elBMI03746 NA PBac{PB}elBc00589 NA PBac{PB}elBc01007 NA PBac{PB}elBc01895 NA PBac{PB}elBc03049 NA PBac{WH}elBf01298 NA PBac{WH}elBf05651a NA PBac{WH}elBf05651b NA insertion of enhancer trap P{lacW}elBk07706 No insertion of enhancer trap binary system P{GAL4}elBGAL4 No P{GAL4}elB-Gal4 No P{GalW}ND115 No
Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
Terms Based on Experimental Evidence ( 10 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with gro (Dorfman et al., 2002) inferred from physical interaction with noc (Dorfman et al., 2002)
Biological Process
CV term Evidence References
cell proliferation inferred from genetic interaction with noc (Luque and Milan, 2007) eye-antennal disc development inferred from mutant phenotype (assigned by UniProtKB) (Luque and Milan, 2007) imaginal disc-derived appendage development inferred from mutant phenotype (assigned by UniProtKB) (Weihe et al., 2004) NOT leg disc development inferred from mutant phenotype (assigned by UniProtKB) (Weihe et al., 2004) negative regulation of gene expression inferred from mutant phenotype (Dorfman et al., 2002) Notch signaling pathway inferred from mutant phenotype (assigned by UniProtKB) (Luque and Milan, 2007) open tracheal system development inferred from mutant phenotype (Dorfman et al., 2002) wing disc development inferred from mutant phenotype (assigned by UniProtKB) (Weihe et al., 2004)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Dorfman et al., 2002)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
nucleic acid binding inferred from electronic annotation with InterPro:IPR013087 (FlyBase Curators et al., 2004-) zinc ion binding inferred from electronic annotation with InterPro:IPR007087, InterPro:IPR015880 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity (Ashburner et al., 1999)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
elB - Atx2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) elB - B52 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) elB - CG10077 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) elB - CG10418 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) elB - CG15735 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) elB - CG16935 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) elB - CG17768 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) elB - CG31075 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) elB - CG3224 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) elB - CG6617 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) elB - CG6724 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) elB - CG6937 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) elB - Cbp20 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) elB - Cbp80 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) elB - Cp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) elB - Cypl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) elB - Dp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) elB - Prosβ7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) elB - RpLP0 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) elB - RpS12 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) elB - Rrp4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) elB - Rrp40 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) elB - Rrp46 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) elB - SmD2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) elB - SmD3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) elB - SmG anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) elB - Thiolase anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) elB - Tim8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) elB - bsf anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) elB - btz anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) elB - ctp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) elB - drk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) elB - isoQC anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) elB - kst anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) elB - mRpS28 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) elB - snf anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) elB - tsu anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions elB allele Gene References elB3.3.1 noc (Weihe et al., 2004) elB12 noc (Davis et al., 1997) elB23 noc (Davis et al., 1997) elB26 noc (Davis et al., 1997) elB27 noc (Davis et al., 1997) elBEP965 CycE (Tseng and Hariharan, 2002) pnr (Pena-Rangel et al., 2002) elBEP2039 CycE (Tseng and Hariharan, 2002) noc (Ashburner et al., 1999) unspecified elA (Davis et al., 1997) H (Mueller et al., 2005) noc (Davis et al., 1997) p53 (Mueller et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60868 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0004858 DroID - A comprehensive database of gene and protein interactions. • FBgn0004858 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34844
Orthologs
OrthoDB Orthologs (16) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6D7ZR7 Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6D7ZR7)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\elB     Drosophila melanogaster fruit fly  Dmel\CG11873     Drosophila sechellia   Dsec\GM21638   Y Drosophila sechellia   Dsec\GM20506   Y Drosophila sechellia   Dsec\GM12764   Y Drosophila erecta   Dere\GG11641   Y Drosophila yakuba   Dyak\GE23832   Y Drosophila yakuba   Dyak\GE25477   Y Drosophila ananassae   Dana\GF16276   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA15009   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA11249   Y Drosophila persimilis   Dper\GL24478   Y Drosophila virilis   Dvir\GJ10539   Y Drosophila virilis   Dvir\GJ15458   Y Drosophila mojavensis   Dmoj\GI24192   Y Drosophila grimshawi   Dgri\GH18682   Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD22008 Drosophila sechellia Dsec\GM14828 Drosophila erecta Dere\GG24258 Drosophila yakuba Dyak\GE25015 Drosophila ananassae Dana\GF15014 Drosophila pseudoobscura pseudoobscura Dpse\GA18043 Drosophila persimilis Dper\GL25769 Drosophila willistoni Dwil\GK18091 Drosophila virilis Dvir\GJ18215 Drosophila mojavensis Dmoj\GI17650 Drosophila grimshawi Dgri\GH13412
Stocks & Reagents
Stocks Listed in FlyBase ( 15 )
Bloomington	4001 elB3/CyO 10332 w1118; PBac{PB}elBc01007 42961 y1 w*; Mi{MIC}elBMI03746 41960 y1 sc* v1; P{TRiP.HMS02357}attP2
Harvard	- PBac{PB}elBc00589 - PBac{PB}elBc01007 - PBac{PB}elBc03049 - PBac{WH}elBf01298 - PBac{WH}elBf05651a, PBac{WH}elBf05651b
VDRC	v104620 P{KK111245}VIE-260B v11763 w1118 P{GD1143}v11763 v42813 w1118; P{GD1143}v42813
	More stocks available...
Genomic Clones ( 2 )
	BACR21J17 BACR37K07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 50 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE67722
Other clones	DPiM_RE67722
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE21910 RE70432
Other clones	21215 28551 34029 34308 64796 65635 73224 74672 77874 81187 82748 83193 83316 100162 102155 149006 214411.3 214413.4 214511.3 CK01.33D.F9 CK01.59D.H11 CK01.101D.D9 CK01.127A.G9 EK022209 EK048430 EK059360 EK078115 EK085913 EK097227 EK135447 EK136332 EK136522 EK148741 EK148828 EK201946 EK204441 EK214639 EK217037 EK217422 EK222758 EK232005 EK252505 EK255124 EK293001 EP10534 EP12225
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004858 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34844
Antibody Information
Other Information
Discoverer
	E. M. Wallace, 1st April 1935. (Ashburner, 1992)
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: elB CG4220 (Kodira, 1999.11) Source for identity of: elB P10 (Wernet, 2001.3.5)
Source for database merge of
Additional comments
Other Comments
	Loss of elB and noc activities induce extensive outgrowths, in a N-dependent way. These overgrowths are not linked to ectopic production of os. (Luque and Milan, 2007) elB appears, with noc, to regulate the growth of the highly proliferative tissue of the eye-head primordium. (Luque and Milan, 2007) elB over-expression nearly perfectly mimics the loss-of-function phenotype of oc, one of the few mutants known to affect opsin regulation. (Wernet et al., 2001) Identification: screen for mutants in opsin regulation and photoreceptor cell type specification. (Wernet et al., 2001) Regulator of inner photoreceptor opsin genes. (Wernet et al., 2001) The elbow locus is made up of two genes, elA and elB, each of which has a distinct phenotype when mutant. Mutations in elA have a strong phenotype with marked disruptions of the wing. Mutations in elB are weak, mainly affecting the alula and wing bristles. elA and elB are dominant enhancers of each other. (Davis et al., 1997) Part of the "elbow-noc" complex. (Ashburner, 1992) Wings extended and bent backward, often warped and shortened; sometimes blistered and nicked. Alulae reduced in size with reduced number of marginal bristles -- may fuse with wing blade. Venation reduced by terminal shortening of L5 and of crossveins. Halteres reduced, often to stubs. Eye size decreased (variable, even with strong alleles). Weak alleles may overlap wild type and show only a reduction in number of marginal bristles on alulae. Some alleles may be semi-lethal when hemizygous. Class (i) alleles enhance nocSco, are semi-lethal with 35Ba alleles of noc and show a weak noc phenotype when heterozygous with strong noc alleles or noc deletions. Class (ii) alleles do not interact with these loci. All alleles more extreme when hemizygous; strong alleles nearly apterous. (Ashburner, 1992)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_205990 RefSeq (Proteins) • NP_995712 DDBJ / EMBL / GenBank • AAF44874 AAF53395 AAM48283 AAN71468 AAO41196 AAS64707 AE003409 AQ025002 AQ025843 AQ074050 AY115567 BI484595 BT001713 CZ466581 CZ467543 CZ483770 CZ483771 Entrez Gene - A searchable database of RefSeq genes. • 34844 UniProtKB/Swiss-Prot • Q9VJS8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2 (IPR007087) Zinc finger, C2H2-like (IPR015880) Zinc finger C2H2-type/integrase DNA-binding domain (IPR013087) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE67722
Linkouts
	BioGRID - A database of protein and genetic interactions • 60868 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0004858 DroID - A comprehensive database of gene and protein interactions. • FBgn0004858 DRSC - Results from RNAi screens. • FBgn0004858 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004858 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4220-RA;CG4220-RA;CG4220-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004858 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34844 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /dbzhnsky/elbow1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34844 modMine - Data generated by the modENCODE project. • FBgn0004858
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	BG:DS06238.3 (Ashburner et al., 1999.10.12, Ashburner et al., 1999) CG4220 (Hadar et al., 2012, Keleman et al., 2009.8.5, Macdonald and Long, 2006, Ni et al., 2010.12.1) el (Weihe et al., 2004, Fuse et al., 1999, Grau et al., 1984, Ashburner, 1992, Gubb et al., 1985, Ashburner et al., 1981, Ashburner et al., 1980, Luque and Milan, 2007, Terriente et al., 2008, Perea et al., 2009) elB (Davis, 2003) elB (Cao et al., 2008, Moorman et al., 2006, Hadar et al., 2012, Negre et al., 2006, Dubruille et al., 2009, Engström et al., 2007, Zhong et al., 2010, Gutiérrez et al., 2012, Tan et al., 2012) elb (Dorfman et al., 2001, Weiss et al., 2010) Elb (Tan et al., 2012) elbow (Ghabrial et al., 2003, Glazer et al., 2000, Palsson and Gibson, 2000, Greaves et al., 1999, Fossett et al., 1994) P10 (Wernet et al., 2001)
Name Synonym	elbow (Luque and Milan, 2007, Terriente et al., 2008, Perea et al., 2009) elbow B (Negre et al., 2006, Morozova et al., 2006, Weiss et al., 2010) elbowB (Zhong et al., 2010) Elbow B (Tan et al., 2012)
Secondary FlyBase IDs
	FBgn0000569
References ( 93 )
Generate a list of	All references relating to this gene ( 93 )
List References by type	Research paper  ( 43 ) Supplementary material  ( 7 ) Review  ( 2 ) Personal communication to FlyBase  ( 25 ) Abstract  ( 7 ) FlyBase analysis  ( 2 ) Curated genome annotation  ( 3 ) Website  ( 1 ) Book  ( 3 )
Recent research papers ( 5 )
	Boiko et al., 2012, J. Biol. Chem. 287(47): 39878--39886 Pickpocket1 is an ionotropic molecular sensory transducer. [FBrf0219990] Gutiérrez et al., 2012, Development 139(1): 117--127 The role of the histone H2A ubiquitinase Sce in Polycomb repression. [FBrf0216868] Hadar et al., 2012, Gene 494(1): 65--72 A screen identifying genes responsive to Dpp and Wg signaling in the Drosophila developing wing. [FBrf0217293] Tan et al., 2012, PLoS Genet. 8(5): e1002681 MicroRNA-277 Modulates the Neurodegeneration Caused by Fragile X Premutation rCGG Repeats. [FBrf0218227] Gabilondo et al., 2011, Mech. Dev. 128(3-4): 208--221 A targeted genetic screen identifies crucial players in the specification of the Drosophila abdominal Capaergic neurons. [FBrf0213290] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...