NK3, NK-3, bgp
Gene model reviewed during 5.49
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\bap using the Feature Mapper tool.
bap is first expressed in 4-8hr embryos, peaks between 4 and 12 hours of embryogenesis and drops off dramatically subsequently. bap is expressed from embryonic stage 10 in the dorsal-most cells of the mesoderm. The bap expression occurs in patches along the anterior-posterior axis in the region corresponding to parasegments 2-12 of the epidermis which will give rise to the visceral mesoderm. Double staining for bap and en shows that the anterior border of each patch aligns with the anterior parasegmental borders. This expression is transient and disappears during stage 11. bap is also expressed in mesodermal cells at the proctodeum and stomodeum. These will develop into the visceral mesoderm of the hindgut and foregut and they continue bap expression until late embryogenesis. After stage 12, bap is also expressed in a subset of heart progenitors.
GBrowse - Visual display of RNA-Seq signalsView Dmel\bap in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
The suggestion that bap and prd9 are the same is incorrect (Frasch, pers. comm. to FlyBase 24th March 1995)
hh is required for the normal activation of bap and srp in anterior portions of each parasegment, whereas wg is required to suppress bap and srp expression in posterior portions. hh and wg play opposing roles in mesoderm segmentation.
The bap gene product is required for the specification of the visceral mesoderm.
Homeobox gene expressed transiently during embryonic development in some mesodermal cells (foregut and hindgut visceral muscle cells). bap poly(A)+ RNA was not detected in 0-3-hour embryos, but was found in low abundance in RNA from 3-6-hour embryos. The abundance was maximum in RNA from 6-12-hour embryos and then declined during further embryonic development.