General Information
Symbol
Dmel\hop
Species
D. melanogaster
Name
hopscotch
Annotation Symbol
CG1594
Feature Type
FlyBase ID
FBgn0004864
Gene Model Status
Stock Availability
Gene Snapshot
Hopscotch (Hop) is a non-receptor tyrosine kinase for interleukin-like ligands (upd1, upd2, and upd3) and functions in the JAK-STAT signaling pathway. It is involved in embryonic segmentation, cell proliferation, and cell migration. [Date last reviewed: 2016-09-01]
Also Known As
JAK, hopscotch, Tum, DmHD-160, l(1)hop
Genomic Location
Cytogenetic map
Sequence location
X:11,360,930..11,368,098 [-]
Recombination map
1-34
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
GO Summary Ribbons
Families, Domains and Molecular Function
Protein Family (UniProt, Sequence Similarities)
Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. (Q24592)
Molecular Function (see GO section for details)
Summaries
Gene Group Membership
NON-RECEPTOR TYROSINE KINASES -
Non-Receptor Tyrosine kinases (nRTK) are cytoplasmic protein kinases that specifically phosphorylate tyrosine residues. nRTKs are involved in signalling cascades and possess targeting domains such as SH2 domains. (Adapted from FBrf0132098).
JAK-STAT Signaling Pathway Core Components -
The JAK-STAT signaling pathway is initiated by the binding of an extracellular ligand to a cell surface receptor leading to receptor dimerization and the intracellular activation of a Janus kinase (JAK) family member. JAK phosphorylates cytoplasmic STAT family members which dimerize, translocate into the nucleus and regulate target gene expression. In Drosophila, the core pathway is limited to three ligands (the Unpaired family of cytokines), a single receptor (dome), JAK kinase (hop) and STAT (Stat92E). (Adapted from FBrf0225259).
UniProt Contributed Function Data
Tyrosine kinase of the non-receptor type, phosphorylates the marelle protein. Required maternally for the establishment of the normal array of embryonic segments: involved in the control of pair-rule gene transcription in a stripe-specific manner. Together with Hsp83 and piwi, mediates canalization, also known as developmental robustness, likely via epigenetic silencing of existing genetic variants and suppression of transposon-induced new genetic variation.
(UniProt, Q24592)
Phenotypic Description from the Red Book (Lindsley and Zimm 1992)
hop: hopscotch
The wild-type allele of hop is required for the continued cell division of all diploid cells as well as the establishment of the normal array of segments. Most of the mutants are homozygous late zygotic (L-P) lethals; one mutant is a larval lethal; two other mutants have some adult survivors (hemizygous males being morphologaically normal, but 40% of the homzygous females and 85% of the hemizygous females showing major defects). Most of the heteroallelic females are lethal, with the following exceptions:
            
 
            genotype      percent viable 
            ____________________________ 
             
            hop29/hop25   12% 
            hop3/hop25    16% 
            hop14/hop25   40% 
            hop12/hop25   68% 
            hop27/hop25   100% 
            hop32/hop25   100% 
            hop33/hop25   100% 
             
             
             
All viable heteroallelic combinations are female sterile, failing to produce eggs or laying abnormal eggs that are small, with a clear chorion and with chorionic filaments absent or partially fused (Perrimon and Mahowald, 1986a). There is a maternal effect on thoracic and abdominal segments, the most extreme embryos [produced from homozygous l(1)hop germline clones that have not received a paternal copy of hop+] showing defects in the posterior spiracles and in segments T2 (denticle belt deleted). T3, A4, and A5 (segment missing) and A8 (segment reduced in size); the least extreme mutant embryos from germline clones show defects in segment A5. Defects visible in early segmentation stages. The extent of the defects is dependent on the strength of the maternal alleles and the paternal contribution. Wild-type sperm can rescue all defects, except those in A5. A few of the rescued progeny hatch and develop into adults.
Tum: Tumorous
Dominant tumorous gene that is a temperature-sensitive lethal at 29 in hemizygous males and homozygous females; about two-thirds of the hemizygous males survive at 18 and one-quarter of these have melanotic tumors. Males raised at 26 and heterozygous females raised at 29 survive to adulthood, but show melanotic masses in the abdominal cavity or small black specks in the legs, wings, or thorax. Mutant larvae kept at 29 show enlargement of the lymph glands in the late second- or early third-instar larvae, but no melanotic masses. By mid third-instar, the lymph glands are large and diffuse and the gastric caeca have become encapsulated and melanized. By late third-instar, the larvae have melanotic masses in the body cavity, lack lymph glands, and have reduced, encapsulated and melanized gastric caeca as well as encapsulated and melanized muscles and fat bodies. These mutants do not survive beyond the late third-instar or the early pupal stage. When lymph glands from Tum larvae are injected into adult female hosts, transplantable neoplasms are produced. Melanization, at first associated with the leg joints and later with the head, thorax, and abdomen, takes place; also abdominal bloating. The lymph glands become melanotic and the abdomen is filled with encapsulated masses before the premature death of the injected individuals. Injection of Tum tissue other than lymph glands fails to produce these effects. The melanotic neoplasms can be transplanted into a succession of hosts in which they produce the same abnormalities. The neoplastic cells resemble hemocytes; some cell lines are melanotic and others are unpigmented, but in both types, the tissue, when transplanted, grows rapidly in the hosts and kills them.
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\hop or the JBrowse view of Dmel\hop for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.52
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0073457
5055
1177
Additional Transcript Data and Comments
Reported size (kB)
5.4, 5.1 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0073313
135.1
1177
7.25
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)
Forms a complex with Hsp83 and piwi; probably Hop mediates the interaction between piwi and Hsp83.
(UniProt, Q24592)
Domain
Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1 (By similarity).
(UniProt, Q24592)
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\hop using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (49 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
inferred from physical interaction with UniProtKB:M9NE35
inferred from physical interaction with UniProtKB:Q9VWE0
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441
(assigned by InterPro )
traceable author statement
inferred from sequence or structural similarity with HGNC:6190
Biological Process (42 terms)
Terms Based on Experimental Evidence (33 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Stat92E; FB:FBgn0016917
inferred from direct assay
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (11 terms)
CV Term
Evidence
References
Cellular Component (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
inferred from direct assay
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
traceable author statement
inferred from electronic annotation with InterPro:IPR000299
(assigned by InterPro )
Expression Data
Transcript Expression
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\hop in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, Transgenic Constructs and Phenotypes
Classical and Insertion Alleles ( 55 )
For All Classical and Insertion Alleles Show
 
Allele of hop
Class
Mutagen
Associated Insertion
Stocks
Known lesion
    0
    Yes
    Other relevant insertions
    Transgenic Constructs ( 22 )
    For All Alleles Carried on Transgenic Constructs Show
    Transgenic constructs containing/affecting coding region of hop
    Allele of hop
    Mutagen
    Associated Transgenic Construct
    Stocks
    Transgenic constructs containing regulatory region of hop
    Deletions and Duplications ( 47 )
    Not disrupted in
    Summary of Phenotypes
    For more details about a specific phenotype click on the relevant allele symbol.
    Lethality
    Allele
    Sterility
    Allele
    Other Phenotypes
    Allele
    Phenotype manifest in
    Allele
    hindgut & nucleus
    hindgut & nucleus, with Scer\GAL4hs.PB
    Orthologs
    Human Orthologs (via DIOPT v7.1)
    Homo sapiens (Human) (25)
    Species\Gene Symbol
    Score
    Best Score
    Best Reverse Score
    Alignment
    Complementation?
    Transgene?
    11 of 15
    Yes
    Yes
    10 of 15
    No
    Yes
    9 of 15
    No
    Yes
    8 of 15
    No
    Yes
    1 of 15
    No
    No
     
    1 of 15
    No
    No
     
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
     
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
     
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
     
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    Model Organism Orthologs (via DIOPT v7.1)
    Mus musculus (laboratory mouse) (24)
    Species\Gene Symbol
    Score
    Best Score
    Best Reverse Score
    Alignment
    Complementation?
    Transgene?
    12 of 15
    Yes
    Yes
    11 of 15
    No
    Yes
    10 of 15
    No
    Yes
    10 of 15
    No
    Yes
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    Rattus norvegicus (Norway rat) (25)
    8 of 13
    Yes
    Yes
    7 of 13
    No
    Yes
    7 of 13
    No
    Yes
    6 of 13
    No
    Yes
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    1 of 13
    No
    No
    Xenopus tropicalis (Western clawed frog) (14)
    10 of 12
    Yes
    Yes
    6 of 12
    No
    Yes
    6 of 12
    No
    Yes
    4 of 12
    No
    Yes
    1 of 12
    No
    No
    1 of 12
    No
    No
    1 of 12
    No
    No
    1 of 12
    No
    No
    1 of 12
    No
    No
    1 of 12
    No
    No
    1 of 12
    No
    No
    1 of 12
    No
    No
    1 of 12
    No
    No
    1 of 12
    No
    No
    Danio rerio (Zebrafish) (24)
    13 of 15
    Yes
    Yes
    11 of 15
    No
    Yes
    10 of 15
    No
    Yes
    7 of 15
    No
    Yes
    5 of 15
    No
    Yes
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    Caenorhabditis elegans (Nematode, roundworm) (4)
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    Arabidopsis thaliana (thale-cress) (1)
    1 of 9
    Yes
    Yes
    Saccharomyces cerevisiae (Brewer's yeast) (1)
    1 of 15
    Yes
    No
    Schizosaccharomyces pombe (Fission yeast) (1)
    1 of 12
    Yes
    No
    Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919011T )
    Organism
    Common Name
    Gene
    AAA Syntenic Ortholog
    Multiple Dmel Genes in this Orthologous Group
    Drosophila melanogaster
    fruit fly
    Drosophila suzukii
    Spotted wing Drosophila
    Drosophila simulans
    Drosophila sechellia
    Drosophila erecta
    Drosophila yakuba
    Drosophila ananassae
    Drosophila pseudoobscura pseudoobscura
    Drosophila persimilis
    Drosophila willistoni
    Drosophila willistoni
    Drosophila virilis
    Drosophila mojavensis
    Drosophila grimshawi
    Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915015J )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Musca domestica
    House fly
    Glossina morsitans
    Tsetse fly
    Lucilia cuprina
    Australian sheep blowfly
    Mayetiola destructor
    Hessian fly
    Aedes aegypti
    Yellow fever mosquito
    Anopheles darlingi
    American malaria mosquito
    Anopheles darlingi
    American malaria mosquito
    Anopheles gambiae
    Malaria mosquito
    Culex quinquefasciatus
    Southern house mosquito
    Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W011A )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Bombyx mori
    Silkmoth
    Danaus plexippus
    Monarch butterfly
    Heliconius melpomene
    Postman butterfly
    Apis florea
    Little honeybee
    Apis mellifera
    Western honey bee
    Bombus impatiens
    Common eastern bumble bee
    Bombus terrestris
    Buff-tailed bumblebee
    Linepithema humile
    Argentine ant
    Megachile rotundata
    Alfalfa leafcutting bee
    Nasonia vitripennis
    Parasitic wasp
    Dendroctonus ponderosae
    Mountain pine beetle
    Dendroctonus ponderosae
    Mountain pine beetle
    Tribolium castaneum
    Red flour beetle
    Pediculus humanus
    Human body louse
    Rhodnius prolixus
    Kissing bug
    Cimex lectularius
    Bed bug
    Acyrthosiphon pisum
    Pea aphid
    Zootermopsis nevadensis
    Nevada dampwood termite
    Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00ZI )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Strigamia maritima
    European centipede
    Ixodes scapularis
    Black-legged tick
    Stegodyphus mimosarum
    African social velvet spider
    Stegodyphus mimosarum
    African social velvet spider
    Tetranychus urticae
    Two-spotted spider mite
    Daphnia pulex
    Water flea
    Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G01IS )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Strongylocentrotus purpuratus
    Purple sea urchin
    Strongylocentrotus purpuratus
    Purple sea urchin
    Ciona intestinalis
    Vase tunicate
    Ciona intestinalis
    Vase tunicate
    Gallus gallus
    Domestic chicken
    Gallus gallus
    Domestic chicken
    Gallus gallus
    Domestic chicken
    Gallus gallus
    Domestic chicken
    Human Disease Model Data
    FlyBase Human Disease Model Reports
    Alleles Reported to Model Human Disease (Disease Ontology)
    Download
    Models ( 2 )
    Allele
    Disease
    Evidence
    References
    inferred from mutant phenotype
    inferred from mutant phenotype
    Interactions ( 3 )
    Allele
    Disease
    Interaction
    References
    Comments ( 0 )
     
    Human Orthologs (via DIOPT v7.1)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    suppressible
    External Data
    Subunit Structure (UniProtKB)
    Forms a complex with Hsp83 and piwi; probably Hop mediates the interaction between piwi and Hsp83.
    (UniProt, Q24592 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    JAK-STAT Signaling Pathway Core Components -
    The JAK-STAT signaling pathway is initiated by the binding of an extracellular ligand to a cell surface receptor leading to receptor dimerization and the intracellular activation of a Janus kinase (JAK) family member. JAK phosphorylates cytoplasmic STAT family members which dimerize, translocate into the nucleus and regulate target gene expression. In Drosophila, the core pathway is limited to three ligands (the Unpaired family of cytokines), a single receptor (dome), JAK kinase (hop) and STAT (Stat92E). (Adapted from FBrf0225259).
    External Data
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    X
    Recombination map
    1-34
    Cytogenetic map
    Sequence location
    X:11,360,930..11,368,098 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    10B5-10B6
    Limits computationally determined from genome sequence between P{EP}CG11756EP1610 and P{EP}CG32666EP1452
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    10B6-10B6
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Notes
    Stocks and Reagents
    Stocks (19)
    Genomic Clones (19)
    cDNA Clones (26)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for identity of: hop CG1594
    Source for database merge of
    Additional comments
    Identified by PCR fragment; relationship to other protein tyrosine kinase genes not known.
    Other Comments
    hop is required for os-induced Stat92E phosphorylation.
    Treatment of S2-derived S2-NP cells with dsRNA made from templates generated with primers directed against hop results in a 12-24-fold decrease in JAK/STAT activity.
    When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of G1 phase cells is seen.
    dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
    Stat92E is part of an intracellular Jak-Stat signalling pathway and is activated by the hop Jak kinase. Partial loss of hop gene product activity gives a phenotype similar to that of Stat92E mutants, supporting the idea that the Jak-Stat pathway is involved in regulation of oogenesis.
    phl acts downstream of hop during differentiation of lamellocytes in larvae.
    hop is required for the renewal of male germline stem cells and for maintenance of the somatic cyst progenitor cell population in the testis.
    hop is required for cell proliferation/survival in the eye imaginal disc, for the differentiation of photoreceptor cells, and for the establishment of the equator and of ommatidial polarity.
    Candidate gene for testicular atrophy quantitative trait locus.
    Dominant hop mutations cause hop to be a hyperactive kinase that can cause hyperactivation of the hop Stat92E pathway.
    Phylogenetic analysis of the PTK family.
    The hop kinase acts upstream of Stat92E in the JAK/STAT pathway. hop may activate Stat92E to regulate transcription of target genes such as eve. Stat92E is epistatic to hop.
    A mutation in Stat92E has been identified by suppression of a hop mutant phenotype.
    An allele of Stat92E was identified in a screen for second site suppressors of hopTum.
    Mutations in Jak kinase, hop, can cause leukaemia-like abnormalities.
    hop is an example of a maternally provided nonreceptor tyrosine kinase involved in segmentation of embryos. hop has a zygotic role in cellular proliferation.
    Mutants display neoplastic phenotype.
    hop is required for cell division and proper embryonic segmentation.
    Identification: Identified by PCR fragment; relationship to other protein tyrosine kinase genes not known.
    Most of the mutants are homozygous late zygotic (L-P) lethals; one mutant is a larval lethal; two other mutants have some adult survivors (hemizygous males being morphologically normal, but 40% of the homozygous females and 85% of the hemizygous females showing major defects). Heteroallelic females are lethal with the exceptions noted under the alleles. There is a maternal effect on thoracic and abdominal segments, the most extreme embryos <up>produced from homozygous "l(1)hop" germ-line clones that have not received a paternal copy of hop+</up> showing defects in the posterior spiracles and in segments T2 (denticle belt deleted). T3, A4 and A5 (segment missing) and A8 (segment reduced in size); the least extreme mutant embryos from germ-line clones show defects in segment A5. Defects visible in early segmentation stages. The extent of the defects is dependent on the strength of the maternal alleles and the paternal contribution. Wild-type sperm can rescue all defects, except those in A5. A few of the rescued progeny hatch and develop into adults.
    The wild-type allele of hop is required for the continued cell division of all diploid cells as well as the establishment of the normal array of segments.
    hop is dosage compensated. All viable heteroallelic combinations are female sterile, failing to produce eggs or laying abnormal eggs that are small, with a clear chorion and with chorionic filaments absent or partially fused.
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 77 )
    Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
    DPiM - Drosophila Protein interaction map
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    FlyMine - An integrated database for Drosophila genomics
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Synonyms and Secondary IDs (32)
    Reported As
    Symbol Synonym
    HD-160
    JAK
    (Terriente-Félix et al., 2017, Yadav et al., 2016, Thomas et al., 2015, Vlisidou and Wood, 2015, Xu and Cherry, 2014, Ferrandon, 2013, Gonzalez, 2013, Tsurumi et al., 2011, Yan et al., 2011, Gutierrez-Aviño et al., 2009, Ayala and Bach, 2008, Bakal et al., 2008, Baudot et al., 2008, Copf and Preat, 2008, Han and Harrison, 2008, Issigonis et al., 2008, McConnell et al., 2008, Sexton and Harrison, 2008, Shi et al., 2008, Wawersik et al., 2008, Wrobel et al., 2008, Yasugi et al., 2008, Assa-Kunik et al., 2007, Ayala et al., 2007, Eleftherianos et al., 2007, Kimble and Page, 2007, Kronhamn et al., 2007, Krzemien et al., 2007, Sotillos and Castelli-Gair, 2007, Castelli-Gair Hombria, 2006, DEVERGNE and NOSELLI, 2006, Guo and Harrison, 2006, Nystul and Spradling, 2006, Sexton et al., 2006, Sheng et al., 2006, Brown et al., 2005, Ip, 2005, Sheng et al., 2005, Meister, 2004, Ohlstein et al., 2004, Starz-Gaiano and Montell, 2004, Terry et al., 2004, Feix et al., 2003, Lopez-Schier, 2003, Mukherjee and Zeidler, 2003, Seyedoleslami Esfahani et al., 2003, Solnica-Krezel and Eaton, 2003, Xi et al., 2003, Castelli-Gair Hombria and Brown, 2002, Harrison et al., 2002, Harrison et al., 2002, Kisseleva et al., 2002, Lavine and Strand, 2002, Rawlings and Harrison, 2002, Silver and Montell, 2002, Mushegian and Medzhitov, 2001, Wasserman and DiNardo, 2001, Lagueux et al., 2000, Morrison et al., 2000, Morrison et al., 2000, Zeidler and Perrimon, 2000, Blair, 1999, Perrimon and Stern, 1999, Zeidler et al., 1999, Mathey-Prevot et al., 1998, Zeidler and Perrimon, 1998)
    hop
    (Bazzi et al., 2018, Borensztejn et al., 2018, Boulet et al., 2018, Poirier et al., 2018, Tokusumi et al., 2018, Lee et al., 2017, Misra et al., 2017, Recasens-Alvarez et al., 2017, Sousa-Victor et al., 2017, Transgenic RNAi Project members, 2017-, Tsurumi et al., 2017, Bielmeier et al., 2016, Lamiable et al., 2016, Padash Barmchi et al., 2016, Saadin and Starz-Gaiano, 2016, Sarov et al., 2016, Zhimulev et al., 2016, Ayyaz et al., 2015, Katsuyama et al., 2015, Liu et al., 2015, Perkins et al., 2015, Seeds et al., 2015, Thomas et al., 2015, Vlachos et al., 2015, Yamamoto-Hino et al., 2015, Zhai et al., 2015, Bausek and Zeidler, 2014, Doherty et al., 2014, Haelterman et al., 2014, Haelterman et al., 2014.3.25, Kim and Choe, 2014, Sopko et al., 2014, Tipping and Perrimon, 2014, Xu et al., 2014, Gunawan et al., 2013, Guo et al., 2013, Kemp et al., 2013, Kingsolver et al., 2013, Morin-Poulard et al., 2013, Radyuk et al., 2013, Shen et al., 2013, Wang et al., 2013, Wells et al., 2013, Yamamoto et al., 2013-, Zeidler and Bausek, 2013, Zoranovic et al., 2013, Amoyel and Bach, 2012, Awofala et al., 2012, Feng et al., 2012, Garcia et al., 2012, Luo and Sehgal, 2012, Zoller and Schulz, 2012, Copf et al., 2011, Jiang et al., 2011, Kugler et al., 2011, Novakova and Dolezal, 2011, Stec and Zeidler, 2011, Tsurumi et al., 2011, Walker et al., 2011, Wang et al., 2011, Wright et al., 2011, Yan et al., 2011, Yoon et al., 2011, Beebe et al., 2010, Bina et al., 2010, Colodner and Feany, 2010, Ekas et al., 2010, Kallio et al., 2010, Lam et al., 2010, Lin et al., 2010, Liu et al., 2010, Makki et al., 2010, Popodi et al., 2010-, Reddy et al., 2010, Sinenko et al., 2010, Sotillos et al., 2010, Stofanko et al., 2010, Venken et al., 2010, Vidal et al., 2010, Almudi et al., 2009, Bertet et al., 2009, Buchon et al., 2009, Buchon et al., 2009, Classen et al., 2009, Flaherty et al., 2009, Gao et al., 2009, Gutierrez-Aviño et al., 2009, Habayeb et al., 2009, Hill-Burns and Clark, 2009, Jacques et al., 2009, Jiang et al., 2009, Kwon et al., 2009, Obbard et al., 2009, Tokusumi et al., 2009, Tokusumi et al., 2009, Copf and Preat, 2008, Han and Harrison, 2008, Kleino et al., 2008, Kwon et al., 2008, Leatherman and DiNardo, 2008, López-Onieva et al., 2008, Ni et al., 2008, Pastor-Pareja et al., 2008, Shi et al., 2008, Sotillos et al., 2008, Starz-Gaiano et al., 2008, Stofanko et al., 2008, Yasugi et al., 2008, Assa-Kunik et al., 2007, Avila and Erickson, 2007, Ayala-Camargo et al., 2007, Bach et al., 2007, Baeg et al., 2007, Beltran et al., 2007, Colinet et al., 2007, Guo and Harrison, 2007, Jang and Montell, 2007, Krzemień et al., 2007, Schlenke et al., 2007, Shen and Tanda, 2007, Sorrentino et al., 2007, Tsai et al., 2007, Xing et al., 2007, Yasugi et al., 2007, Zeitlinger et al., 2007, Brun et al., 2006, Ekas et al., 2006, Minakhina and Steward, 2006, Oishi et al., 2006, Rehwinkel et al., 2006, Shi et al., 2006, Hombria et al., 2005, Mukherjee et al., 2005, Rehwinkel et al., 2005, Wawersik et al., 2005, Wertheim et al., 2005, Xie et al., 2005, Yamashita et al., 2005, Rawlings et al., 2004, Sinenko and Mathey-Prevot, 2004, Tsai and Sun, 2004, Munier et al., 2002)
    l(1)G18
    msvl
    Name Synonyms
    JAK kinase
    Janus-family kinase
    Tumorous
    Secondary FlyBase IDs
    • FBgn0001211
    • FBgn0003895
    • FBgn0022799
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (561)