Gene Dmel\hop

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General Information

Symbol

Dmel\hop

Species

D. melanogaster

Name

hopscotch

Annotation symbol

CG1594

Feature type

protein_coding_gene

FlyBase ID

FBgn0004864

Gene Model Status

Current

Stock availability

14 publicly available

Also Known As

JAK, DmHD-160, l(1)hop, Tum, 4

Genomic Location

Chromosome (arm)

Recombination map

1-34.6

Cytogenetic map

10B5-10B6

Sequence location

X:11,254,932..11,262,130 [-]

Genomic Maps

Select View:

Summary Information

Automatically generated summary

See sections below for more information

The gene hopscotch is referred to in FlyBase by the symbol Dmel\hop (CG1594, FBgn0004864). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: protein tyrosine kinase activity. There is experimental evidence for 30 unique biological process terms, many of which group under: single-organism developmental process; biological regulation; sensory organ development; regulation of developmental process; immune system process; cellular component movement; cellular component organization or biogenesis; localization; establishment of planar polarity; embryonic pattern specification. 77 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; multicellular structure; embryonic/larval hemocoel; external compound sense organ; adult segment; larval abdominal segment; portion of tissue; non-connected developing system; peripheral nervous system. It has one annotated transcript and one annotated polypeptide. Protein features are: Band 4.1 domain; FERM domain; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; SH2 domain; Serine-threonine/tyrosine-protein kinase catalytic domain; Tyrosine-protein kinase, active site; Tyrosine-protein kinase, catalytic domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1639072_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of hop. Gene sequence location is X:11254932..11262130.

User Contributed Data

Beta version, feedback welcome

External Summaries

Phenotypic Description from the Red Book (Lindsley & Zimm 1992)

Gene/Allele symbols may differ from current usage

hop: hopscotch

The wild-type allele of hop is required for the continued cell division of all diploid cells as well as the establishment of the normal array of segments. Most of the mutants are homozygous late zygotic (L-P) lethals; one mutant is a larval lethal; two other mutants have some adult survivors (hemizygous males being morphologaically normal, but 40% of the homzygous females and 85% of the hemizygous females showing major defects). Most of the heteroallelic females are lethal, with the following exceptions:

            
 
            genotype      percent viable 
            ____________________________ 
             
            hop29/hop25   12% 
            hop3/hop25    16% 
            hop14/hop25   40% 
            hop12/hop25   68% 
            hop27/hop25   100% 
            hop32/hop25   100% 
            hop33/hop25   100%

All viable heteroallelic combinations are female sterile, failing to produce eggs or laying abnormal eggs that are small, with a clear chorion and with chorionic filaments absent or partially fused (Perrimon and Mahowald, 1986a). There is a maternal effect on thoracic and abdominal segments, the most extreme embryos [produced from homozygous l(1)hop germline clones that have not received a paternal copy of hop+] showing defects in the posterior spiracles and in segments T2 (denticle belt deleted). T3, A4, and A5 (segment missing) and A8 (segment reduced in size); the least extreme mutant embryos from germline clones show defects in segment A5. Defects visible in early segmentation stages. The extent of the defects is dependent on the strength of the maternal alleles and the paternal contribution. Wild-type sperm can rescue all defects, except those in A5. A few of the rescued progeny hatch and develop into adults.

Tum: Tumorous

Dominant tumorous gene that is a temperature-sensitive lethal at 29 in hemizygous males and homozygous females; about two-thirds of the hemizygous males survive at 18 and one-quarter of these have melanotic tumors. Males raised at 26 and heterozygous females raised at 29 survive to adulthood, but show melanotic masses in the abdominal cavity or small black specks in the legs, wings, or thorax. Mutant larvae kept at 29 show enlargement of the lymph glands in the late second- or early third-instar larvae, but no melanotic masses. By mid third-instar, the lymph glands are large and diffuse and the gastric caeca have become encapsulated and melanized. By late third-instar, the larvae have melanotic masses in the body cavity, lack lymph glands, and have reduced, encapsulated and melanized gastric caeca as well as encapsulated and melanized muscles and fat bodies. These mutants do not survive beyond the late third-instar or the early pupal stage. When lymph glands from Tum larvae are injected into adult female hosts, transplantable neoplasms are produced. Melanization, at first associated with the leg joints and later with the head, thorax, and abdomen, takes place; also abdominal bloating. The lymph glands become melanotic and the abdomen is filled with encapsulated masses before the premature death of the injected individuals. Injection of Tum tissue other than lymph glands fails to produce these effects. The melanotic neoplasms can be transplanted into a succession of hosts in which they produce the same abnormalities. The neoplastic cells resemble hemocytes; some cell lines are melanotic and others are unpigmented, but in both types, the tissue, when transplanted, grows rapidly in the hosts and kills them.

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

FB2013_02

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Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

10B5-10B6

Limits computationally determined from genome sequence between P{EP}CG11756^EP1610 and P{EP}CG32666^EP1452

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

10B6-10B6

(determined by in situ hybridisation)

(Dearolf, 1993)

10B6-10B6

(determined by in situ hybridisation)

(Binari and Perrimon, 1991)

Experimentally Determined Recombination Data

Location

1-34.6

1-34.61

(Geer et al., 1983, Perrimon and Mahowald, 1986, Binari and Perrimon, 1994)

Left of (cM)

dlg1

(Perrimon and Mahowald, 1986, Binari and Perrimon, 1994)

Right of (cM)

(Perrimon and Mahowald, 1986, Binari and Perrimon, 1994)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\hop for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

DGC clone HL03036 appears problematic: incomplete CDS

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

hop-RA

FBtr0073457

NM_078564

5085

1177

Additional Transcript Data & Comments

Reported size (kB)

5.4, 5.1 (northern blot)

(Binari and Perrimon, 1994)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

hop-PA

FBpp0073313

135.1

1177

7.25

NP_511119

AAF48035

Additional Polypeptide Data & Comments

Reported size (kDa)

1177 (aa)

(Binari and Perrimon, 1994)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

FERM domain (IPR000299)

Protein kinase, catalytic domain (IPR000719)

SH2 domain (IPR000980)

Tyrosine-protein kinase, active site (IPR008266)

Protein kinase-like domain (IPR011009)

Protein kinase, ATP binding site (IPR017441)

Band 4.1 domain (IPR019749)

Tyrosine-protein kinase, catalytic domain (IPR020635)

Serine-threonine/tyrosine-protein kinase catalytic domain (IPR001245)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Q24592

UniProtKB/TrEMBL

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage | early

(Binari and Perrimon, 1994)

embryonic stage -- adult stage

(Binari and Perrimon, 1994)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	gene max expression
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		289.425
Larval Midgut		181.2
Larval Hindgut		218
Larval Malpighian Tubules		215
Larval Fat Body		195.6
Larval Salivary Gland		471.2
Larval Trachea		242.275
Larval Carcass		218.25
Adult Head		127.4
Adult Eye		157.75
Adult Brain		233.8
Adult Thoracic-Abdominal Ganglion		186
Adult Crop		191.6
Adult Midgut		190
Adult Hindgut		157.6
Adult Malpighian Tubules		193
Adult Fat Body		163.1
Adult Salivary Gland		307.4
Adult Heart		143.275
Adult VirginFemale Spermatheca		185.1
Adult InseminatedFemale Spermatheca		217.7
Adult Ovary		286.1
Adult Testis		28.7
Adult Male Accessory Gland		297.3
Adult Carcass		127.8
Expression Level Scale		None Low Moderate High

Linear, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		289.425
Larval Midgut		181.2
Larval Hindgut		218
Larval Malpighian Tubules		215
Larval Fat Body		195.6
Larval Salivary Gland		471.2
Larval Trachea		242.275
Larval Carcass		218.25
Adult Head		127.4
Adult Eye		157.75
Adult Brain		233.8
Adult Thoracic-Abdominal Ganglion		186
Adult Crop		191.6
Adult Midgut		190
Adult Hindgut		157.6
Adult Malpighian Tubules		193
Adult Fat Body		163.1
Adult Salivary Gland		307.4
Adult Heart		143.275
Adult VirginFemale Spermatheca		185.1
Adult InseminatedFemale Spermatheca		217.7
Adult Ovary		286.1
Adult Testis		28.7
Adult Male Accessory Gland		297.3
Adult Carcass		127.8
Expression Level Scale		None Low Moderate High

Linear, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		289.425
Larval Midgut		181.2
Larval Hindgut		218
Larval Malpighian Tubules		215
Larval Fat Body		195.6
Larval Salivary Gland		471.2
Larval Trachea		242.275
Larval Carcass		218.25
Adult Head		127.4
Adult Eye		157.75
Adult Brain		233.8
Adult Thoracic-Abdominal Ganglion		186
Adult Crop		191.6
Adult Midgut		190
Adult Hindgut		157.6
Adult Malpighian Tubules		193
Adult Fat Body		163.1
Adult Salivary Gland		307.4
Adult Heart		143.275
Adult VirginFemale Spermatheca		185.1
Adult InseminatedFemale Spermatheca		217.7
Adult Ovary		286.1
Adult Testis		28.7
Adult Male Accessory Gland		297.3
Adult Carcass		127.8
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		289.425
Larval Midgut		181.2
Larval Hindgut		218
Larval Malpighian Tubules		215
Larval Fat Body		195.6
Larval Salivary Gland		471.2
Larval Trachea		242.275
Larval Carcass		218.25
Adult Head		127.4
Adult Eye		157.75
Adult Brain		233.8
Adult Thoracic-Abdominal Ganglion		186
Adult Crop		191.6
Adult Midgut		190
Adult Hindgut		157.6
Adult Malpighian Tubules		193
Adult Fat Body		163.1
Adult Salivary Gland		307.4
Adult Heart		143.275
Adult VirginFemale Spermatheca		185.1
Adult InseminatedFemale Spermatheca		217.7
Adult Ovary		286.1
Adult Testis		28.7
Adult Male Accessory Gland		297.3
Adult Carcass		127.8
Expression Level Scale		Very high

log, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		289.425
Larval Midgut		181.2
Larval Hindgut		218
Larval Malpighian Tubules		215
Larval Fat Body		195.6
Larval Salivary Gland		471.2
Larval Trachea		242.275
Larval Carcass		218.25
Adult Head		127.4
Adult Eye		157.75
Adult Brain		233.8
Adult Thoracic-Abdominal Ganglion		186
Adult Crop		191.6
Adult Midgut		190
Adult Hindgut		157.6
Adult Malpighian Tubules		193
Adult Fat Body		163.1
Adult Salivary Gland		307.4
Adult Heart		143.275
Adult VirginFemale Spermatheca		185.1
Adult InseminatedFemale Spermatheca		217.7
Adult Ovary		286.1
Adult Testis		28.7
Adult Male Accessory Gland		297.3
Adult Carcass		127.8
Expression Level Scale		None Low Moderate High

log, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		289.425
Larval Midgut		181.2
Larval Hindgut		218
Larval Malpighian Tubules		215
Larval Fat Body		195.6
Larval Salivary Gland		471.2
Larval Trachea		242.275
Larval Carcass		218.25
Adult Head		127.4
Adult Eye		157.75
Adult Brain		233.8
Adult Thoracic-Abdominal Ganglion		186
Adult Crop		191.6
Adult Midgut		190
Adult Hindgut		157.6
Adult Malpighian Tubules		193
Adult Fat Body		163.1
Adult Salivary Gland		307.4
Adult Heart		143.275
Adult VirginFemale Spermatheca		185.1
Adult InseminatedFemale Spermatheca		217.7
Adult Ovary		286.1
Adult Testis		28.7
Adult Male Accessory Gland		297.3
Adult Carcass		127.8
Expression Level Scale		None Low Moderate High

log, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		289.425
Larval Midgut		181.2
Larval Hindgut		218
Larval Malpighian Tubules		215
Larval Fat Body		195.6
Larval Salivary Gland		471.2
Larval Trachea		242.275
Larval Carcass		218.25
Adult Head		127.4
Adult Eye		157.75
Adult Brain		233.8
Adult Thoracic-Abdominal Ganglion		186
Adult Crop		191.6
Adult Midgut		190
Adult Hindgut		157.6
Adult Malpighian Tubules		193
Adult Fat Body		163.1
Adult Salivary Gland		307.4
Adult Heart		143.275
Adult VirginFemale Spermatheca		185.1
Adult InseminatedFemale Spermatheca		217.7
Adult Ovary		286.1
Adult Testis		28.7
Adult Male Accessory Gland		297.3
Adult Carcass		127.8
Expression Level Scale		None Low Moderate High Very high

log, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		289.425
Larval Midgut		181.2
Larval Hindgut		218
Larval Malpighian Tubules		215
Larval Fat Body		195.6
Larval Salivary Gland		471.2
Larval Trachea		242.275
Larval Carcass		218.25
Adult Head		127.4
Adult Eye		157.75
Adult Brain		233.8
Adult Thoracic-Abdominal Ganglion		186
Adult Crop		191.6
Adult Midgut		190
Adult Hindgut		157.6
Adult Malpighian Tubules		193
Adult Fat Body		163.1
Adult Salivary Gland		307.4
Adult Heart		143.275
Adult VirginFemale Spermatheca		185.1
Adult InseminatedFemale Spermatheca		217.7
Adult Ovary		286.1
Adult Testis		28.7
Adult Male Accessory Gland		297.3
Adult Carcass		127.8
Expression Level Scale		None Low Moderate High Very high

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level	Tissue	Adult Expression Level
NA	Head	127.4
NA	Eye	157.75
NA	Brain	233.8
289.425	Central Nervous System	NA
NA	Thoracic-Abdominal Ganglion	186
NA	Crop	191.6
181.2	Midgut	190
218	Hindgut	157.6
215	Malpighian Tubules	193
195.6	Fat Body	163.1
471.2	Salivary Gland	307.4
NA	Heart	143.275
242.275	Trachea	NA
NA	VirginFemale Spermatheca	185.1
NA	InseminatedFemale Spermatheca	217.7
NA	Ovary	286.1
NA	Testis	28.7
NA	Male Accessory Gland	297.3
218.25	Carcass	127.8

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		14
central nervous system, larvae L3		10
central nervous system, pupae P8		7
head, virgin 1-day female		4
head, virgin 4-day female		4
head, virgin 20-day female		4
head, mated 1-day female		4
head, mated 4-day female		3
head, mated 20-day female		4
head, mated 1-day male		5
head, mated 4-day male		6
head, mated 20-day male		7
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		7
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		3
digestive system, 4-day adult		4
digestive system, 20-day adult		5
fat body, larvae L3 wandering		2
fat body, white prepupae		7
fat body, pupae P8		4
carcass, larvae L3 wandering		10
carcass, 1-day adult		3
carcass, 4-day adult		4
carcass, 20-day adult		5
ovary, virgin 4-day female		33
ovary, mated 4-day female		30
testis, mated 4-day male		3
accessory gland, mated 4-day male		4
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		14
central nervous system, larvae L3		10
central nervous system, pupae P8		7
head, virgin 1-day female		4
head, virgin 4-day female		4
head, virgin 20-day female		4
head, mated 1-day female		4
head, mated 4-day female		3
head, mated 20-day female		4
head, mated 1-day male		5
head, mated 4-day male		6
head, mated 20-day male		7
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		7
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		3
digestive system, 4-day adult		4
digestive system, 20-day adult		5
fat body, larvae L3 wandering		2
fat body, white prepupae		7
fat body, pupae P8		4
carcass, larvae L3 wandering		10
carcass, 1-day adult		3
carcass, 4-day adult		4
carcass, 20-day adult		5
ovary, virgin 4-day female		(33)
ovary, mated 4-day female		(30)
testis, mated 4-day male		3
accessory gland, mated 4-day male		4
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		14
central nervous system, larvae L3		10
central nervous system, pupae P8		7
head, virgin 1-day female		4
head, virgin 4-day female		4
head, virgin 20-day female		4
head, mated 1-day female		4
head, mated 4-day female		3
head, mated 20-day female		4
head, mated 1-day male		5
head, mated 4-day male		6
head, mated 20-day male		7
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		7
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		3
digestive system, 4-day adult		4
digestive system, 20-day adult		5
fat body, larvae L3 wandering		2
fat body, white prepupae		7
fat body, pupae P8		4
carcass, larvae L3 wandering		10
carcass, 1-day adult		3
carcass, 4-day adult		4
carcass, 20-day adult		5
ovary, virgin 4-day female		33
ovary, mated 4-day female		30
testis, mated 4-day male		3
accessory gland, mated 4-day male		4
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		14
central nervous system, larvae L3		10
central nervous system, pupae P8		7
head, virgin 1-day female		4
head, virgin 4-day female		4
head, virgin 20-day female		4
head, mated 1-day female		4
head, mated 4-day female		3
head, mated 20-day female		4
head, mated 1-day male		5
head, mated 4-day male		6
head, mated 20-day male		7
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		7
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		3
digestive system, 4-day adult		4
digestive system, 20-day adult		5
fat body, larvae L3 wandering		2
fat body, white prepupae		7
fat body, pupae P8		4
carcass, larvae L3 wandering		10
carcass, 1-day adult		3
carcass, 4-day adult		4
carcass, 20-day adult		5
ovary, virgin 4-day female		33
ovary, mated 4-day female		30
testis, mated 4-day male		3
accessory gland, mated 4-day male		4
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		14
central nervous system, larvae L3		10
central nervous system, pupae P8		7
head, virgin 1-day female		4
head, virgin 4-day female		4
head, virgin 20-day female		4
head, mated 1-day female		4
head, mated 4-day female		3
head, mated 20-day female		4
head, mated 1-day male		5
head, mated 4-day male		6
head, mated 20-day male		7
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		7
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		3
digestive system, 4-day adult		4
digestive system, 20-day adult		5
fat body, larvae L3 wandering		2
fat body, white prepupae		7
fat body, pupae P8		4
carcass, larvae L3 wandering		10
carcass, 1-day adult		3
carcass, 4-day adult		4
carcass, 20-day adult		5
ovary, virgin 4-day female		33
ovary, mated 4-day female		30
testis, mated 4-day male		3
accessory gland, mated 4-day male		4
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		14
central nervous system, larvae L3		10
central nervous system, pupae P8		7
head, virgin 1-day female		4
head, virgin 4-day female		4
head, virgin 20-day female		4
head, mated 1-day female		4
head, mated 4-day female		3
head, mated 20-day female		4
head, mated 1-day male		5
head, mated 4-day male		6
head, mated 20-day male		7
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		7
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		3
digestive system, 4-day adult		4
digestive system, 20-day adult		5
fat body, larvae L3 wandering		2
fat body, white prepupae		7
fat body, pupae P8		4
carcass, larvae L3 wandering		10
carcass, 1-day adult		3
carcass, 4-day adult		4
carcass, 20-day adult		5
ovary, virgin 4-day female		(33)
ovary, mated 4-day female		30
testis, mated 4-day male		3
accessory gland, mated 4-day male		4
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		14
central nervous system, larvae L3		10
central nervous system, pupae P8		7
head, virgin 1-day female		4
head, virgin 4-day female		4
head, virgin 20-day female		4
head, mated 1-day female		4
head, mated 4-day female		3
head, mated 20-day female		4
head, mated 1-day male		5
head, mated 4-day male		6
head, mated 20-day male		7
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		7
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		3
digestive system, 4-day adult		4
digestive system, 20-day adult		5
fat body, larvae L3 wandering		2
fat body, white prepupae		7
fat body, pupae P8		4
carcass, larvae L3 wandering		10
carcass, 1-day adult		3
carcass, 4-day adult		4
carcass, 20-day adult		5
ovary, virgin 4-day female		33
ovary, mated 4-day female		30
testis, mated 4-day male		3
accessory gland, mated 4-day male		4
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		14
central nervous system, larvae L3		10
central nervous system, pupae P8		7
head, virgin 1-day female		4
head, virgin 4-day female		4
head, virgin 20-day female		4
head, mated 1-day female		4
head, mated 4-day female		3
head, mated 20-day female		4
head, mated 1-day male		5
head, mated 4-day male		6
head, mated 20-day male		7
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		7
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		3
digestive system, 4-day adult		4
digestive system, 20-day adult		5
fat body, larvae L3 wandering		2
fat body, white prepupae		7
fat body, pupae P8		4
carcass, larvae L3 wandering		10
carcass, 1-day adult		3
carcass, 4-day adult		4
carcass, 20-day adult		5
ovary, virgin 4-day female		33
ovary, mated 4-day female		30
testis, mated 4-day male		3
accessory gland, mated 4-day male		4
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		52
embryo 02-04hr		47
embryo 04-06hr		29
embryo 06-08hr		26
embryo 08-10hr		26
embryo 10-12hr		15
embryo 12-14hr		17
embryo 14-16hr		18
embryo 16-18hr		13
embryo 18-20hr		10
embryo 20-22hr		10
embryo 22-24hr		11
larva L1		10
larva L2		8
larva L3 12hr old		7
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		11
larva L3 puffstage 7-9		13
white prepupae new		15
white prepupae 12hr		12
white prepupae 24hr		15
pupae 2d postWPP		11
pupae 3d postWPP		7
pupae 4d postWPP		6
adult male 01day		7
adult male 05day		8
adult male 30day		9
adult female 01day		20
adult female 05day		30
adult female 30day		31
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(52)
embryo 02-04hr		(47)
embryo 04-06hr		(29)
embryo 06-08hr		26
embryo 08-10hr		26
embryo 10-12hr		15
embryo 12-14hr		17
embryo 14-16hr		18
embryo 16-18hr		13
embryo 18-20hr		10
embryo 20-22hr		10
embryo 22-24hr		11
larva L1		10
larva L2		8
larva L3 12hr old		7
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		11
larva L3 puffstage 7-9		13
white prepupae new		15
white prepupae 12hr		12
white prepupae 24hr		15
pupae 2d postWPP		11
pupae 3d postWPP		7
pupae 4d postWPP		6
adult male 01day		7
adult male 05day		8
adult male 30day		9
adult female 01day		20
adult female 05day		(30)
adult female 30day		(31)
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		52
embryo 02-04hr		47
embryo 04-06hr		29
embryo 06-08hr		26
embryo 08-10hr		26
embryo 10-12hr		15
embryo 12-14hr		17
embryo 14-16hr		18
embryo 16-18hr		13
embryo 18-20hr		10
embryo 20-22hr		10
embryo 22-24hr		11
larva L1		10
larva L2		8
larva L3 12hr old		7
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		11
larva L3 puffstage 7-9		13
white prepupae new		15
white prepupae 12hr		12
white prepupae 24hr		15
pupae 2d postWPP		11
pupae 3d postWPP		7
pupae 4d postWPP		6
adult male 01day		7
adult male 05day		8
adult male 30day		9
adult female 01day		20
adult female 05day		30
adult female 30day		31
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		52
embryo 02-04hr		47
embryo 04-06hr		29
embryo 06-08hr		26
embryo 08-10hr		26
embryo 10-12hr		15
embryo 12-14hr		17
embryo 14-16hr		18
embryo 16-18hr		13
embryo 18-20hr		10
embryo 20-22hr		10
embryo 22-24hr		11
larva L1		10
larva L2		8
larva L3 12hr old		7
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		11
larva L3 puffstage 7-9		13
white prepupae new		15
white prepupae 12hr		12
white prepupae 24hr		15
pupae 2d postWPP		11
pupae 3d postWPP		7
pupae 4d postWPP		6
adult male 01day		7
adult male 05day		8
adult male 30day		9
adult female 01day		20
adult female 05day		30
adult female 30day		31
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		52
embryo 02-04hr		47
embryo 04-06hr		29
embryo 06-08hr		26
embryo 08-10hr		26
embryo 10-12hr		15
embryo 12-14hr		17
embryo 14-16hr		18
embryo 16-18hr		13
embryo 18-20hr		10
embryo 20-22hr		10
embryo 22-24hr		11
larva L1		10
larva L2		8
larva L3 12hr old		7
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		11
larva L3 puffstage 7-9		13
white prepupae new		15
white prepupae 12hr		12
white prepupae 24hr		15
pupae 2d postWPP		11
pupae 3d postWPP		7
pupae 4d postWPP		6
adult male 01day		7
adult male 05day		8
adult male 30day		9
adult female 01day		20
adult female 05day		30
adult female 30day		31
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(52)
embryo 02-04hr		(47)
embryo 04-06hr		29
embryo 06-08hr		26
embryo 08-10hr		26
embryo 10-12hr		15
embryo 12-14hr		17
embryo 14-16hr		18
embryo 16-18hr		13
embryo 18-20hr		10
embryo 20-22hr		10
embryo 22-24hr		11
larva L1		10
larva L2		8
larva L3 12hr old		7
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		11
larva L3 puffstage 7-9		13
white prepupae new		15
white prepupae 12hr		12
white prepupae 24hr		15
pupae 2d postWPP		11
pupae 3d postWPP		7
pupae 4d postWPP		6
adult male 01day		7
adult male 05day		8
adult male 30day		9
adult female 01day		20
adult female 05day		30
adult female 30day		31
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		52
embryo 02-04hr		47
embryo 04-06hr		29
embryo 06-08hr		26
embryo 08-10hr		26
embryo 10-12hr		15
embryo 12-14hr		17
embryo 14-16hr		18
embryo 16-18hr		13
embryo 18-20hr		10
embryo 20-22hr		10
embryo 22-24hr		11
larva L1		10
larva L2		8
larva L3 12hr old		7
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		11
larva L3 puffstage 7-9		13
white prepupae new		15
white prepupae 12hr		12
white prepupae 24hr		15
pupae 2d postWPP		11
pupae 3d postWPP		7
pupae 4d postWPP		6
adult male 01day		7
adult male 05day		8
adult male 30day		9
adult female 01day		20
adult female 05day		30
adult female 30day		31
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		52
embryo 02-04hr		47
embryo 04-06hr		29
embryo 06-08hr		26
embryo 08-10hr		26
embryo 10-12hr		15
embryo 12-14hr		17
embryo 14-16hr		18
embryo 16-18hr		13
embryo 18-20hr		10
embryo 20-22hr		10
embryo 22-24hr		11
larva L1		10
larva L2		8
larva L3 12hr old		7
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		11
larva L3 puffstage 7-9		13
white prepupae new		15
white prepupae 12hr		12
white prepupae 24hr		15
pupae 2d postWPP		11
pupae 3d postWPP		7
pupae 4d postWPP		6
adult male 01day		7
adult male 05day		8
adult male 30day		9
adult female 01day		20
adult female 05day		30
adult female 30day		31
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		10
Schneider line 2 Sg4		6
embryonic 1182-4H		11
embryonic GM2		13
embryonic Kc167		8
embryonic S1		12
embryonic S3		8
leg disc CME L1		9
wing disc CME-W2		5
wing disc ML-DmD8		9
wing disc ML-DmD9		14
wing disc ML-DmD16-c3		13
wing disc ML-DmD21		4
wing disc ML-DmD32		8
haltere disc ML-DmD17-c3		11
eye-antennal disc ML-DmD11		8
antennal disc ML-DmD20-c5		5
mixed discs ML-DmD4-c1		8
CNS ML-DmBG1-c1		11
CNS ML-DmBG2-c2		9
tumorous blood cells mbn2		12
ovary fGS/OSS		16
ovary OSC		12
ovary OSS		8
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		10
Schneider line 2 Sg4		6
embryonic 1182-4H		11
embryonic GM2		13
embryonic Kc167		8
embryonic S1		12
embryonic S3		8
leg disc CME L1		9
wing disc CME-W2		5
wing disc ML-DmD8		9
wing disc ML-DmD9		14
wing disc ML-DmD16-c3		13
wing disc ML-DmD21		4
wing disc ML-DmD32		8
haltere disc ML-DmD17-c3		11
eye-antennal disc ML-DmD11		8
antennal disc ML-DmD20-c5		5
mixed discs ML-DmD4-c1		8
CNS ML-DmBG1-c1		11
CNS ML-DmBG2-c2		9
tumorous blood cells mbn2		12
ovary fGS/OSS		16
ovary OSC		12
ovary OSS		8
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		10
Schneider line 2 Sg4		6
embryonic 1182-4H		11
embryonic GM2		13
embryonic Kc167		8
embryonic S1		12
embryonic S3		8
leg disc CME L1		9
wing disc CME-W2		5
wing disc ML-DmD8		9
wing disc ML-DmD9		14
wing disc ML-DmD16-c3		13
wing disc ML-DmD21		4
wing disc ML-DmD32		8
haltere disc ML-DmD17-c3		11
eye-antennal disc ML-DmD11		8
antennal disc ML-DmD20-c5		5
mixed discs ML-DmD4-c1		8
CNS ML-DmBG1-c1		11
CNS ML-DmBG2-c2		9
tumorous blood cells mbn2		12
ovary fGS/OSS		16
ovary OSC		12
ovary OSS		8
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		10
Schneider line 2 Sg4		6
embryonic 1182-4H		11
embryonic GM2		13
embryonic Kc167		8
embryonic S1		12
embryonic S3		8
leg disc CME L1		9
wing disc CME-W2		5
wing disc ML-DmD8		9
wing disc ML-DmD9		14
wing disc ML-DmD16-c3		13
wing disc ML-DmD21		4
wing disc ML-DmD32		8
haltere disc ML-DmD17-c3		11
eye-antennal disc ML-DmD11		8
antennal disc ML-DmD20-c5		5
mixed discs ML-DmD4-c1		8
CNS ML-DmBG1-c1		11
CNS ML-DmBG2-c2		9
tumorous blood cells mbn2		12
ovary fGS/OSS		16
ovary OSC		12
ovary OSS		8
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		10
Schneider line 2 Sg4		6
embryonic 1182-4H		11
embryonic GM2		13
embryonic Kc167		8
embryonic S1		12
embryonic S3		8
leg disc CME L1		9
wing disc CME-W2		5
wing disc ML-DmD8		9
wing disc ML-DmD9		14
wing disc ML-DmD16-c3		13
wing disc ML-DmD21		4
wing disc ML-DmD32		8
haltere disc ML-DmD17-c3		11
eye-antennal disc ML-DmD11		8
antennal disc ML-DmD20-c5		5
mixed discs ML-DmD4-c1		8
CNS ML-DmBG1-c1		11
CNS ML-DmBG2-c2		9
tumorous blood cells mbn2		12
ovary fGS/OSS		16
ovary OSC		12
ovary OSS		8
Expression Level Scale		Very low Low Moderate

log, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		10
Schneider line 2 Sg4		6
embryonic 1182-4H		11
embryonic GM2		13
embryonic Kc167		8
embryonic S1		12
embryonic S3		8
leg disc CME L1		9
wing disc CME-W2		5
wing disc ML-DmD8		9
wing disc ML-DmD9		14
wing disc ML-DmD16-c3		13
wing disc ML-DmD21		4
wing disc ML-DmD32		8
haltere disc ML-DmD17-c3		11
eye-antennal disc ML-DmD11		8
antennal disc ML-DmD20-c5		5
mixed discs ML-DmD4-c1		8
CNS ML-DmBG1-c1		11
CNS ML-DmBG2-c2		9
tumorous blood cells mbn2		12
ovary fGS/OSS		16
ovary OSC		12
ovary OSS		8
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		10
Schneider line 2 Sg4		6
embryonic 1182-4H		11
embryonic GM2		13
embryonic Kc167		8
embryonic S1		12
embryonic S3		8
leg disc CME L1		9
wing disc CME-W2		5
wing disc ML-DmD8		9
wing disc ML-DmD9		14
wing disc ML-DmD16-c3		13
wing disc ML-DmD21		4
wing disc ML-DmD32		8
haltere disc ML-DmD17-c3		11
eye-antennal disc ML-DmD11		8
antennal disc ML-DmD20-c5		5
mixed discs ML-DmD4-c1		8
CNS ML-DmBG1-c1		11
CNS ML-DmBG2-c2		9
tumorous blood cells mbn2		12
ovary fGS/OSS		16
ovary OSC		12
ovary OSS		8
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		10
Schneider line 2 Sg4		6
embryonic 1182-4H		11
embryonic GM2		13
embryonic Kc167		8
embryonic S1		12
embryonic S3		8
leg disc CME L1		9
wing disc CME-W2		5
wing disc ML-DmD8		9
wing disc ML-DmD9		14
wing disc ML-DmD16-c3		13
wing disc ML-DmD21		4
wing disc ML-DmD32		8
haltere disc ML-DmD17-c3		11
eye-antennal disc ML-DmD11		8
antennal disc ML-DmD20-c5		5
mixed discs ML-DmD4-c1		8
CNS ML-DmBG1-c1		11
CNS ML-DmBG2-c2		9
tumorous blood cells mbn2		12
ovary fGS/OSS		16
ovary OSC		12
ovary OSS		8
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Cell Line		Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		5
heat shock, 4-day adult		10
Cadmium 50 mM 6 hrs, larvae L3		3
Cadmium 50 mM 12 hrs, larvae L3		3
Cadmium 50 mM 48 hrs, 4-day adult		9
Cadmium 100 mM 48 hrs, 4-day adult		20
Copper 0.5 mM 12 hrs, larvae L3		2
Copper 15 mM 48 hrs, 4-day adult		10
Zinc 5 mM 12 hrs, larvae L3		2
Zinc 4.5 mM 48 hrs, 4-day adult		5
Ethanol 2.5% 3 hrs, larvae L3		25
Ethanol 5% 3 hrs, larvae L3		4
Ethanol 10% 3 hrs, larvae L3		3
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		19
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		16
Paraquat 10 mM 48 hrs, 4-day adult		18
Rotenone 2 μg 12 hrs, larvae L3		4
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		5
heat shock, 4-day adult		10
Cadmium 50 mM 6 hrs, larvae L3		3
Cadmium 50 mM 12 hrs, larvae L3		3
Cadmium 50 mM 48 hrs, 4-day adult		9
Cadmium 100 mM 48 hrs, 4-day adult		20
Copper 0.5 mM 12 hrs, larvae L3		2
Copper 15 mM 48 hrs, 4-day adult		10
Zinc 5 mM 12 hrs, larvae L3		2
Zinc 4.5 mM 48 hrs, 4-day adult		5
Ethanol 2.5% 3 hrs, larvae L3		25
Ethanol 5% 3 hrs, larvae L3		4
Ethanol 10% 3 hrs, larvae L3		3
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		19
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		16
Paraquat 10 mM 48 hrs, 4-day adult		18
Rotenone 2 μg 12 hrs, larvae L3		4
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		5
heat shock, 4-day adult		10
Cadmium 50 mM 6 hrs, larvae L3		3
Cadmium 50 mM 12 hrs, larvae L3		3
Cadmium 50 mM 48 hrs, 4-day adult		9
Cadmium 100 mM 48 hrs, 4-day adult		20
Copper 0.5 mM 12 hrs, larvae L3		2
Copper 15 mM 48 hrs, 4-day adult		10
Zinc 5 mM 12 hrs, larvae L3		2
Zinc 4.5 mM 48 hrs, 4-day adult		5
Ethanol 2.5% 3 hrs, larvae L3		25
Ethanol 5% 3 hrs, larvae L3		4
Ethanol 10% 3 hrs, larvae L3		3
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		19
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		16
Paraquat 10 mM 48 hrs, 4-day adult		18
Rotenone 2 μg 12 hrs, larvae L3		4
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		5
heat shock, 4-day adult		10
Cadmium 50 mM 6 hrs, larvae L3		3
Cadmium 50 mM 12 hrs, larvae L3		3
Cadmium 50 mM 48 hrs, 4-day adult		9
Cadmium 100 mM 48 hrs, 4-day adult		20
Copper 0.5 mM 12 hrs, larvae L3		2
Copper 15 mM 48 hrs, 4-day adult		10
Zinc 5 mM 12 hrs, larvae L3		2
Zinc 4.5 mM 48 hrs, 4-day adult		5
Ethanol 2.5% 3 hrs, larvae L3		25
Ethanol 5% 3 hrs, larvae L3		4
Ethanol 10% 3 hrs, larvae L3		3
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		19
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		16
Paraquat 10 mM 48 hrs, 4-day adult		18
Rotenone 2 μg 12 hrs, larvae L3		4
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		5
heat shock, 4-day adult		10
Cadmium 50 mM 6 hrs, larvae L3		3
Cadmium 50 mM 12 hrs, larvae L3		3
Cadmium 50 mM 48 hrs, 4-day adult		9
Cadmium 100 mM 48 hrs, 4-day adult		20
Copper 0.5 mM 12 hrs, larvae L3		2
Copper 15 mM 48 hrs, 4-day adult		10
Zinc 5 mM 12 hrs, larvae L3		2
Zinc 4.5 mM 48 hrs, 4-day adult		5
Ethanol 2.5% 3 hrs, larvae L3		25
Ethanol 5% 3 hrs, larvae L3		4
Ethanol 10% 3 hrs, larvae L3		3
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		19
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		16
Paraquat 10 mM 48 hrs, 4-day adult		18
Rotenone 2 μg 12 hrs, larvae L3		4
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		5
heat shock, 4-day adult		10
Cadmium 50 mM 6 hrs, larvae L3		3
Cadmium 50 mM 12 hrs, larvae L3		3
Cadmium 50 mM 48 hrs, 4-day adult		9
Cadmium 100 mM 48 hrs, 4-day adult		20
Copper 0.5 mM 12 hrs, larvae L3		2
Copper 15 mM 48 hrs, 4-day adult		10
Zinc 5 mM 12 hrs, larvae L3		2
Zinc 4.5 mM 48 hrs, 4-day adult		5
Ethanol 2.5% 3 hrs, larvae L3		25
Ethanol 5% 3 hrs, larvae L3		4
Ethanol 10% 3 hrs, larvae L3		3
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		19
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		16
Paraquat 10 mM 48 hrs, 4-day adult		18
Rotenone 2 μg 12 hrs, larvae L3		4
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		5
heat shock, 4-day adult		10
Cadmium 50 mM 6 hrs, larvae L3		3
Cadmium 50 mM 12 hrs, larvae L3		3
Cadmium 50 mM 48 hrs, 4-day adult		9
Cadmium 100 mM 48 hrs, 4-day adult		20
Copper 0.5 mM 12 hrs, larvae L3		2
Copper 15 mM 48 hrs, 4-day adult		10
Zinc 5 mM 12 hrs, larvae L3		2
Zinc 4.5 mM 48 hrs, 4-day adult		5
Ethanol 2.5% 3 hrs, larvae L3		25
Ethanol 5% 3 hrs, larvae L3		4
Ethanol 10% 3 hrs, larvae L3		3
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		19
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		16
Paraquat 10 mM 48 hrs, 4-day adult		18
Rotenone 2 μg 12 hrs, larvae L3		4
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		5
heat shock, 4-day adult		10
Cadmium 50 mM 6 hrs, larvae L3		3
Cadmium 50 mM 12 hrs, larvae L3		3
Cadmium 50 mM 48 hrs, 4-day adult		9
Cadmium 100 mM 48 hrs, 4-day adult		20
Copper 0.5 mM 12 hrs, larvae L3		2
Copper 15 mM 48 hrs, 4-day adult		10
Zinc 5 mM 12 hrs, larvae L3		2
Zinc 4.5 mM 48 hrs, 4-day adult		5
Ethanol 2.5% 3 hrs, larvae L3		25
Ethanol 5% 3 hrs, larvae L3		4
Ethanol 10% 3 hrs, larvae L3		3
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		19
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		16
Paraquat 10 mM 48 hrs, 4-day adult		18
Rotenone 2 μg 12 hrs, larvae L3		4
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010, Graveley et al., 2011)

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0004864

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG1594-RA

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

lethal

lethal, with Scer\GAL4^dpp.blk1

hop^Tum.Scer\UAS

lethal, with Scer\GAL4^en-e16E

hop^Scer\UAS.cHa

lethal, with Scer\GAL4^hs.PB

lethal (with hop²⁵)

lethal (with hop²⁹)

hop²⁵

lethal (with hop^M637)

hop²⁵

lethal | dominant | heat sensitive

lethal | dominant | larval stage

hop²

lethal | embryonic stage | germline clone | recessive | rescuable maternal effect

lethal | embryonic stage | recessive | rescuable maternal effect

lethal | germline clone | recessive | rescuable maternal effect

hop¹²

lethal | heat sensitive

lethal | larval stage

lethal | larval stage, with Scer\GAL4^dome-PG125

hop^Tum.Scer\UAS

lethal | larval stage | heat sensitive

hop^Tum

lethal | larval stage | maternal effect

hop¹²

lethal | larval stage | recessive

lethal | maternal effect | polyphasic

hop²⁵

lethal | maternal effect | pupal stage

hop¹²

lethal | partially

hop^Tum

lethal | partially (with hop²⁵)

lethal | partially (with hop³²)

hop²⁵

lethal | partially (with hop³³)

hop²⁵

lethal | partially | recessive

hop²⁵

lethal | polyphasic | recessive

hop^air

lethal | recessive

lethal | recessive | heat sensitive

hop^Tum

lethal | rescuable maternal effect

lethal | semidominant

hop^Tum

partially lethal - majority die (with Df(3L)ED4238)

hop^Tum

partially lethal - majority die | dominant | heat sensitive

hop^Tum

partially lethal - majority die | embryonic stage | maternal effect

hop²⁵

viable

viable, with Scer\GAL4^pnr-MD237

hop^GD9157

viable (with hop³)

hop²⁵

viable (with hop¹²)

hop²⁵

viable (with hop¹⁴)

hop²⁵

viable (with hop²⁵)

viable (with hop²⁷)

hop²⁵

Sterility

Allele

female sterile

hop²⁵

fertile | female | reduced (with hop³)

hop²⁵

fertile | female | reduced (with hop²⁵)

hop³

male sterile

Other Phenotypes

Allele

cell shape defective | extended germ band stage | germline clone

hop²

hyperplasia

hop^Tum

hyperplasia | third instar larval stage

hop^Tum

immune response defective (with hop²⁵)

hop³²

immune response defective (with hop³²)

hop²⁵

immune response defective | heat sensitive

hop^Tum

increased cell number

hop^Tum

increased cell number | third instar larval stage

hop^Tum

locomotor rhythm defective

hop²⁵

locomotor rhythm defective | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

hop^Tum.Scer\UAS

melanotic mass phenotype

hop^Tum

melanotic mass phenotype, with Scer\GAL4^Cg.PA

hop^Tum.Scer\UAS

melanotic mass phenotype, with Scer\GAL4^Dot.PK

melanotic mass phenotype | adult stage | dominant

hop^Tum

melanotic mass phenotype | dominant

hop^Tum

melanotic mass phenotype | dominant | heat sensitive

melanotic mass phenotype | heat sensitive

hop^Tum

melanotic mass phenotype | larval stage

hop^Tum

melanotic mass phenotype | somatic clone, with Scer\GAL4^Act5C.PI

hop^Scer\UAS.cHa

memory defective | adult stage, with Scer\GAL4^c739

hop^{dsRNA.Scer\UAS.cCa}

memory defective | adult stage | heat sensitive, with Scer\GAL4^ey-OK107, Scer\GAL80^ts.αTub84B

hop^{dsRNA.Scer\UAS.cCa}

memory defective | adult stage | RU486 conditional, with Scer\GAL4^{Mef2.247.Switch}

hop^{dsRNA.Scer\UAS.cCa}

neuroanatomy defective | larval stage

hop^Tum.Scer\UAS

planar polarity defective

hop³

planar polarity defective | cell autonomous | somatic clone

planar polarity defective | cell non-autonomous | recessive | somatic clone

hop²

planar polarity defective | cell non-autonomous | somatic clone

planar polarity defective | heat sensitive

hop²⁵

tumorigenic

hop^Tum

tumorigenic (with Df(3L)ED4238)

hop^Tum

visible

visible, with Scer\GAL4^dpp.blk1

hop^Scer\UAS.cHa

visible, with Scer\GAL4^elav.PLu

visible, with Scer\GAL4^en-e16E

hop^Scer\UAS.cHa

visible, with Scer\GAL4^ey.PH

visible, with Scer\GAL4^ey.PU

hop^Tum.Scer\UAS

visible, with Scer\GAL4^GMR.PF

visible, with Scer\GAL4^hs.PB

visible (with hop²⁵)

hop³²

visible (with hop³²)

hop²⁵

visible | adult stage, with Scer\GAL4^en-e16E

visible | dominant

hop^Tum

visible | dominant | heat sensitive

visible | heat sensitive

visible | recessive

hop^air

wild-type

hop^T-r7.Act5C

Phenotype manifest in

Allele

abdomen

hop^Tum

abdominal 4 ventral denticle belt

hop²

abdominal 4 ventral denticle belt | germline clone | maternal effect

abdominal 5 ventral denticle belt

hop²

abdominal 5 ventral denticle belt | germline clone | maternal effect

abdominal 6 ventral denticle belt

hop²

abdominal 7 ventral denticle belt

hop²

abdominal 7 ventral denticle belt | germline clone | maternal effect

hop²⁵

abdominal 8 ventral denticle belt

hop²

axon

hop^Tum

axon, with Scer\GAL4^hs.PB

hop^Scer\UAS.cHa

axoneme

hop²⁵

border follicle cell

hop²

border follicle cell, with Scer\GAL4^c306

hop^Tum.Scer\UAS

border follicle cell, with Scer\GAL4^slbo.2.6

hop^Scer\UAS.cHa

border follicle cell (with hop²)

hop²⁵

border follicle cell (with hop²⁵)

hop²

border follicle cell | ectopic, with Scer\GAL4^c306

border follicle cell | ectopic, with Scer\GAL4^slbo.2.6

hop^Tum.Scer\UAS

border follicle cell | ectopic | somatic clone, with Scer\GAL4^Act5C.PP

hop^Scer\UAS.cHa

border follicle cell | somatic clone

hop²

centripetally migrating follicle cell (with hop²)

hop²⁵

centripetally migrating follicle cell (with hop²⁵)

hop²

centripetally migrating follicle cell | somatic clone, with Scer\GAL4^Act5C.PP

hop^Scer\UAS.cHa

crystal cell

hop^Tum

cyst progenitor cell

hop²⁵

cyst progenitor cell | supernumerary, with Scer\GAL4^A3.eya

hop^Tum.Scer\UAS

denticle belt | germline clone | rescuable maternal effect

hop²

dorsal trunk primordium | germline clone | maternal effect

hop²

ectoderm | extended germ band stage | germline clone

hop²

egg chamber (with hop³)

hop²⁵

egg chamber (with hop²⁵)

egg chamber (with hop²⁷)

hop²⁵

egg chamber (with hop³²)

hop²⁵

embryonic/larval anterior spiracle

hop^T42

embryonic/larval brain

hop^T42

embryonic/larval fat body

hop^T42

embryonic/larval foregut | embryonic stage

hop^T42

embryonic/larval hemocyte

embryonic/larval hemocyte | supernumerary

hop^Tum

embryonic/larval hemocyte | supernumerary, with Scer\GAL4^stop.Hml

hop^Tum.Scer\UAS

embryonic/larval hemocyte | third instar larval stage

hop^Tum

embryonic/larval hindgut | embryonic stage

hop^T42

embryonic/larval lymph gland

embryonic/larval lymph gland | third instar larval stage

hop^Tum

embryonic/larval midgut | embryonic stage

hop^T42

embryonic/larval proventriculus

hop²

embryonic abdominal segment 4

hop²

embryonic abdominal segment 4 | non-rescuable maternal effect

hop²

embryonic abdominal segment 5

hop²

embryonic abdominal segment 5 | non-rescuable maternal effect

hop²

embryonic abdominal segment | germline clone | maternal effect

embryonic head

hop²

embryonic hindgut, with Scer\GAL4^byn-Gal4

hop^Tum.Scer\UAS

embryonic hindgut | germline clone

hop²

eye

eye, with Scer\GAL4^dpp.blk1

hop^Scer\UAS.cHa

eye, with Scer\GAL4^elav.PLu

eye, with Scer\GAL4^ey.PH

eye, with Scer\GAL4^ey.PU

hop^Tum.Scer\UAS

eye, with Scer\GAL4^GMR.PF

eye, with Scer\GAL4^T13

hop^Scer\UAS.cHa

eye | somatic clone

eye equator | ectopic

eye photoreceptor cell

hop²⁵

eye photoreceptor cell | somatic clone

filzkorper | germline clone | maternal effect

follicle cell | posterior (with hop²)

hop²⁵

follicle cell | posterior (with hop²⁵)

hop²

gastric caecum

hop^T42

gonad | maternal effect

hop²

hemocyte

hop^Tum

hemocyte | precursor

hop^Tum

hemocyte | supernumerary

hop^Tum

hindgut

hop^Tum

hindgut, with Scer\GAL4^hs.PB

hop^Scer\UAS.cHa

hindgut & nucleus

hop^Tum

hindgut & nucleus, with Scer\GAL4^hs.PB

hop^Scer\UAS.cHa

interfollicle cell (with hop³)

hop²⁵

interfollicle cell (with hop²⁵)

interfollicle cell (with hop³²)

hop²⁵

interfollicle cell (with hop³³)

hop²⁵

interommatidial bristle

lamellocyte

hop^Tum

lamellocyte, with Scer\GAL4^He.PZ

hop^Tum.Scer\UAS

lamellocyte | ectopic

hop^Tum

lamellocyte | larval stage | supernumerary

hop^Tum

lamellocyte | supernumerary

hop^Tum

lamellocyte | supernumerary, with Scer\GAL4^Cg.PA

hop^Tum.Scer\UAS

lamellocyte | third instar larval stage

hop^Tum

larval outer optic anlage, with Scer\GAL4^C855a

hop^Tum.Scer\UAS

male germline cell | supernumerary, with Scer\GAL4^{nos.UTR.T:Hsim\VP16}

hop^Tum.Scer\UAS

male germline stem cell

male germline stem cell | supernumerary, with Scer\GAL4^A3.eya

hop^Tum.Scer\UAS

melanotic mass

hop^Tum

melanotic mass, with Scer\GAL4^Cg.PA

hop^Tum.Scer\UAS

melanotic mass, with Scer\GAL4^Dot.PK

melanotic mass, with Scer\GAL4^He.PZ

hop^Tum.Scer\UAS

melanotic mass | adult stage

hop^Tum

melanotic mass | heat sensitive

hop^Tum

melanotic mass | somatic clone, with Scer\GAL4^Act5C.PI

hop^Scer\UAS.cHa

mesothoracic ventral denticle belt

hop²

nurse follicle cell (with hop²)

hop²⁵

nurse follicle cell (with hop²⁵)

hop²

nurse follicle cell | somatic clone

hop²

ommatidium

ommatidium | cell non-autonomous | somatic clone

hop²

ommatidium | somatic clone

oocyte associated follicle cell (with hop²)

hop²⁵

oocyte associated follicle cell (with hop²⁵)

hop²

ovary

hop^T-r7

peripheral nervous system

hop^Tum

peripheral nervous system, with Scer\GAL4^hs.PB

hop^Scer\UAS.cHa

plasmatocyte

hop^Tum

plasmatocyte | supernumerary

hop^Tum

plasmatocyte | supernumerary, with Scer\GAL4^Cg.PA

hop^Tum.Scer\UAS

podocyte

hop^Tum

polar follicle cell | supernumerary (with hop³)

hop²⁵

polar follicle cell | supernumerary (with hop²⁵)

polar follicle cell | supernumerary (with hop²⁷)

hop²⁵

polar follicle cell | supernumerary (with hop³³)

hop²⁵

pole cell | ectopic

hop^Tum

pole cell | maternal effect

hop²

pole cell | supernumerary

hop^Tum

presumptive embryonic/larval tracheal system

hop²

scutellum, with Scer\GAL4^T59

hop^Scer\UAS.cHa

scutum, with Scer\GAL4^c754

hop^Scer\UAS.cHa

segment | germline clone

hop¹²

spermatogonium

telson

hop²

testis

testis, with Scer\GAL4^A3.eya

hop^Tum.Scer\UAS

testis, with Scer\GAL4^{nos.UTR.T:Hsim\VP16}

hop^Tum.Scer\UAS

tracheal branch primordium | germline clone | maternal effect

hop²

tracheal pit

hop^Tum

tracheal pit, with Scer\GAL4^hs.PB

hop^Scer\UAS.cHa

wing, with Scer\GAL4^T59

hop^Scer\UAS.cHa

wing vein, with Scer\GAL4^en-e16E

hop^Scer\UAS.cHa

wing vein, with Scer\GAL4^T59

hop^Scer\UAS.cHa

wing vein | ectopic, with Scer\GAL4^en-e16E

wing vein | ectopic (with hop²⁵)

hop³²

wing vein | ectopic (with hop³²)

hop²⁵

Classical Alleles ( 54 )

For All Classical Alleles Show

Allele of hop	Class	Mutagen	Stocks	Known lesion
hop²	loss of function allele, amorphic allele - genetic evidence	X ray	2	Yes
hop²⁷	amorphic allele - genetic evidence	ethyl nitrosourea	1	Yes
hop³	amorphic allele - genetic evidence	X ray	1	Yes
hop²⁵	hypomorphic allele - genetic evidence	ethyl methanesulfonate	1	Yes
hop^GG01333			1	--
hop^KG01990		P-element activity	1	--
hop^Tum	heat sensitive neomorphic allele - genetic evidence	ethyl methanesulfonate	1	Yes
hop¹²	amorphic allele - genetic evidence	ethyl methanesulfonate	0	Yes
hop¹³	amorphic allele - genetic evidence	ethyl methanesulfonate	0	Yes
hop¹⁴	amorphic allele - genetic evidence	ethyl methanesulfonate	0	Yes
hop¹⁵	amorphic allele - genetic evidence	ethyl methanesulfonate	0	--
hop¹⁶	amorphic allele - genetic evidence	ethyl methanesulfonate	0	--
hop¹	amorphic allele - genetic evidence	X ray ethyl methanesulfonate	0	--
hop²⁹	amorphic allele - genetic evidence	ethyl nitrosourea	0	Yes
hop³²	amorphic allele - genetic evidence	ethyl nitrosourea	0	Yes
hop³³	amorphic allele - genetic evidence	ethyl nitrosourea	0	--
hop³⁴	amorphic allele - genetic evidence	ethyl methanesulfonate	0	Yes
hop³⁵	amorphic allele - genetic evidence	ethyl methanesulfonate	0	--
hop⁴	amorphic allele - genetic evidence	X ray	0	Yes
hop⁹	amorphic allele - genetic evidence	ethyl methanesulfonate	0	Yes
hop¹⁰		ethyl methanesulfonate	0	--
hop¹¹		ethyl methanesulfonate	0	--
hop¹⁷		ethyl methanesulfonate	0	--
hop¹⁸		ethyl methanesulfonate	0	--
hop¹⁹		ethyl methanesulfonate	0	--
hop²⁰		ethyl methanesulfonate	0	Yes
hop²¹		ethyl methanesulfonate	0	--
hop²²		ethyl methanesulfonate	0	--
hop²³		ethyl methanesulfonate	0	--
hop²⁴		ethyl methanesulfonate	0	--
hop²⁶		ethyl methanesulfonate	0	--
hop²⁸		ethyl nitrosourea	0	--
hop³⁰		ethyl nitrosourea	0	--
hop³¹		ethyl nitrosourea	0	--
hop⁵		X ray	0	--
hop⁶		X ray	0	--
hop⁷		X ray	0	--
hop⁸		ethyl methanesulfonate	0	--
hop^air	loss of function allele	P-element activity PM hybrid dysgenesis	0	--
hop^F1.1			0	Yes
hop^J1A.1			0	Yes
hop^M637		PM hybrid dysgenesis	0	Yes
hop^M637rev1		PM hybrid dysgenesis	0	--
hop^r1	loss of function allele	gamma ray	0	--
hop^r2	loss of function allele	gamma ray	0	--
hop^r3	loss of function allele	gamma ray	0	--
hop^r4	loss of function allele	gamma ray	0	--
hop^r5	loss of function allele	gamma ray	0	--
hop^T-r7		ethyl methanesulfonate	0	--
hop^T42		ethyl methanesulfonate	0	Yes
hop^unspecified			0	--
hop^X-139-3		ethyl methanesulfonate	0	--
hop^X-170-25		ethyl methanesulfonate	0	--
hop^X-82-36		ethyl methanesulfonate	0	--

Alleles Carried on Transgenic Constructs ( 23 )

For All Alleles Carried on Transgenic Constructs Show

Allele of hop	Mutagen	Stocks	Known lesion
hop^GD9157	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
hop^GL00305	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
hop^HMS00761	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
hop^JF01267	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
hop^JF01268	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
hop^KK105136	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
hop^Act5C.PH	in vitro construct - minigene in vitro construct - regulatory fusion	0	Yes
hop^Act5C.PK	in vitro construct - regulatory fusion	0	Yes
hop^Act5C.PY	in vitro construct - regulatory fusion	0	Yes
hop^{Act5C.T:Hsap\MYC}	in vitro construct - regulatory fusion in vitro construct - coding region fusion	0	Yes
hop^{dsRNA.Scer\UAS.cCa}	in vitro construct - regulatory fusion in vitro construct - RNAi	0	Yes
hop^{dsRNA.Scer\UAS.cMa}	in vitro construct - regulatory fusion in vitro construct - RNAi	0	Yes
hop^hs.PB	in vitro construct - regulatory fusion	0	Yes
hop^hs.PH	in vitro construct - minigene in vitro construct - regulatory fusion	0	Yes
hop^{MtnA.T:SV5\V5}	in vitro construct - regulatory fusion in vitro construct - coding region fusion	0	Yes
hop^Scer\UAS.cHa	in vitro construct - minigene in vitro construct - regulatory fusion	0	Yes
hop^T-r7.Act5C	in vitro construct - minigene in vitro construct - regulatory fusion	0	Yes
hop^T42.Act5C	in vitro construct - regulatory fusion	0	Yes
hop^Tum.Act5C	in vitro construct - minigene in vitro construct - regulatory fusion	0	Yes
hop^Tum.hs	in vitro construct - minigene in vitro construct - regulatory fusion	0	Yes
hop^Tum.Scer\UAS	in vitro construct - minigene in vitro construct - regulatory fusion	0	Yes
hop^TumL.Act5C	in vitro construct - regulatory fusion	0	Yes
hop^ΔJH2.Act5C	in vitro construct - deletion	0	Yes

Aneuploid Aberrations

Duplicated in

Dp(1;2)v⁺65b

(Geer et al., 1983, Eeken et al., 1985, Zhimulev et al., 1987, Watson et al., 1991, Hanratty and Dearolf, 1993)

Dp(1;2)v⁺75d

(Geer et al., 1983, Eeken et al., 1985, Hanratty and Dearolf, 1993)

Dp(1;3)DC238

(Popodi et al., 2010-, Venken et al., 2010)

Dp(1;3)v⁺74c

(Eeken et al., 1985)

Dp(1;Y)dsh⁺y⁺

(Zhimulev et al., 1987)

Dp(1;Y)v⁺y⁺

(Geer et al., 1983, Zhimulev et al., 1987, Woods and Bryant, 1989, Watson et al., 1991, Hanratty and Dearolf, 1993)

Dp(1;Y)v⁺y⁺366

(Zhimulev et al., 1987)

Dp(1;Y)y⁺v⁺#3

(Eeken et al., 1985, Watson et al., 1991, Hanratty and Dearolf, 1993)

Not disrupted in

Df(1)59D3

(Zhimulev et al., 1987)

Df(1)203C10

(Zhimulev et al., 1987)

Df(1)DA622

(Woods and Bryant, 1989, Hanratty and Dearolf, 1993, Binari and Perrimon, 1994, Caggese et al., 1994)

Df(1)HA85

(Hanratty and Dearolf, 1993)

Df(1)HC133

(Zhimulev et al., 1987)

Df(1)HF368

(Eeken et al., 1985)

Df(1)m13

(Woods and Bryant, 1989, Hanratty and Dearolf, 1993, Caggese et al., 1994)

Df(1)m259-4

(Eeken et al., 1985, Hanratty and Dearolf, 1993)

Df(1)N71

(Eeken et al., 1985)

Df(1)ras-P14

(Zhimulev et al., 1987)

Df(1)ras-v17

(Zhimulev et al., 1987, Hanratty and Dearolf, 1993)

Df(1)ras-v-P26

(Zhimulev et al., 1987)

Df(1)sbr1

(Zhimulev et al., 1987)

Df(1)sbr8

(Zhimulev et al., 1987)

Df(1)sbr9

(Zhimulev et al., 1987)

Df(1)sbr10

(Zhimulev et al., 1987)

Df(1)v64f

(Zhimulev et al., 1987, Hanratty and Dearolf, 1993)

Df(1)v-B151

(Zhimulev et al., 1987)

Df(1)v-L1

(Geer et al., 1983, Zhimulev et al., 1987)

Df(1)v-L2

(Geer et al., 1983, Zhimulev et al., 1987, Hanratty and Dearolf, 1993)

Df(1)v-L3

(Geer et al., 1983, Eeken et al., 1985, Zhimulev et al., 1987, Hanratty and Dearolf, 1993)

Df(1)v-L4

(Geer et al., 1983, Eeken et al., 1985, Zhimulev et al., 1987)

Df(1)v-L7

(Zhimulev et al., 1987)

Df(1)v-L11

(Zhimulev et al., 1987)

Df(1)v-L15

(Eeken et al., 1985, Zhimulev et al., 1987, Hanratty and Dearolf, 1993)

Df(1)v-M1

(Zhimulev et al., 1987)

Df(1)v-M5

(Zhimulev et al., 1987)

Df(1)v-M6

(Zhimulev et al., 1987)

Df(1)v-M7

(Zhimulev et al., 1987)

Df(1)v-P5

(Zhimulev et al., 1987)

Df(1)v-P16

(Zhimulev et al., 1987)

Df(1)v-P22

(Zhimulev et al., 1987)

Not duplicated in

Dp(1;2)r⁺75c

(Watson et al., 1991)

Dp(1;2)v⁺63i

(Geer et al., 1983, Eeken et al., 1985, Zhimulev et al., 1987, Watson et al., 1991, Hanratty and Dearolf, 1993)

Dp(1;3)f⁺71b

(Watson et al., 1991)

Dp(1;Y)v⁺y⁺U15

(Zhimulev et al., 1987)

Disrupted in

Df(1)GA112

(Hanratty and Dearolf, 1993)

Df(1)KA7

(Zhimulev et al., 1987, Hanratty and Dearolf, 1993)

Df(1)N71

(Zhimulev et al., 1987, Woods and Bryant, 1989, Hanratty and Dearolf, 1993, Binari and Perrimon, 1994, Caggese et al., 1994, Harbecke and Lengyel, 1995)

Df(1)RA37

(Zhimulev et al., 1987, Woods and Bryant, 1989, Hanratty and Dearolf, 1993, Caggese et al., 1994)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

heat-shock construct

characterization construct

P{Act/T-r7}

P{Act/Tum-l}

Insertions

Type of insertions

Name

Expression data

miscellaneous insertions

P{}hop^air

P{}hop^M637

P{SUPor-P}hop^KG01990

insertion of mobile activating element

P{Mae-UAS.6.11}hop^GG01333

Gene Ontology: Function, Process & Cellular Component ( 54 unique terms )

Terms Based on Experimental Evidence ( 30 terms )

Molecular Function ( 0 terms)

Biological Process

CV term

Evidence

References

apical constriction