A Database of Drosophila Genes & Genomes

FB2012_01, released January 20th, 2012
 

Gene Dmel\hop

General Information
SymbolDmel\hopSpeciesD. melanogaster
NamehopscotchAnnotation symbolCG1594
Feature typeprotein_coding_geneFlyBase IDFBgn0004864
Gene Model StatusCurrent Stock availability 15 publicly available
Also Known AsJAK, DmHD-160, l(1)hop, Tum, 4
Genomic Location
Chromosome (arm)XRecombination map1-34.6
Cytogenetic map10B5-10B6Sequence locationX:11,254,932..11,262,130 [-]

Genomic Maps

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Automatically generated summary

See sections below for more information
The gene hopscotch is referred to in FlyBase by the symbol Dmel\hop (CG1594, FBgn0004864). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: protein tyrosine kinase activity. There is experimental evidence for 28 unique biological process terms, many of which group under: anatomical structure development; biological regulation; sensory organ development; cellular process involved in reproduction; regulation of developmental process; cellular component organization or biogenesis; organ morphogenesis; embryonic pattern specification; multicellular organismal reproductive process; establishment of planar polarity. 77 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; female germline cyst; abdominal ventral denticle belt; hemocyte; external compound sense organ; embryonic/larval hemocoel; adult segment; podocyte; non-connected developing system. It has one annotated transcript and one annotated polypeptide. Protein features are: Band 4.1 domain; FERM domain; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; SH2 motif; Serine-threonine/tyrosine-protein kinase; Tyrosine-protein kinase, active site; Tyrosine-protein kinase, catalytic domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1639072_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of hop. Gene sequence location is X:11254932..11262130.

External Summaries
hide Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage
hop: hopscotch
The wild-type allele of hop is required for the continued cell division of all diploid cells as well as the establishment of the normal array of segments. Most of the mutants are homozygous late zygotic (L-P) lethals; one mutant is a larval lethal; two other mutants have some adult survivors (hemizygous males being morphologaically normal, but 40% of the homzygous females and 85% of the hemizygous females showing major defects). Most of the heteroallelic females are lethal, with the following exceptions:
            
 
            genotype      percent viable 
            ____________________________ 
             
            hop29/hop25   12% 
            hop3/hop25    16% 
            hop14/hop25   40% 
            hop12/hop25   68% 
            hop27/hop25   100% 
            hop32/hop25   100% 
            hop33/hop25   100% 
             
             
             
All viable heteroallelic combinations are female sterile, failing to produce eggs or laying abnormal eggs that are small, with a clear chorion and with chorionic filaments absent or partially fused (Perrimon and Mahowald, 1986a). There is a maternal effect on thoracic and abdominal segments, the most extreme embryos [produced from homozygous l(1)hop germline clones that have not received a paternal copy of hop+] showing defects in the posterior spiracles and in segments T2 (denticle belt deleted). T3, A4, and A5 (segment missing) and A8 (segment reduced in size); the least extreme mutant embryos from germline clones show defects in segment A5. Defects visible in early segmentation stages. The extent of the defects is dependent on the strength of the maternal alleles and the paternal contribution. Wild-type sperm can rescue all defects, except those in A5. A few of the rescued progeny hatch and develop into adults.
Tum: Tumorous
Dominant tumorous gene that is a temperature-sensitive lethal at 29 in hemizygous males and homozygous females; about two-thirds of the hemizygous males survive at 18 and one-quarter of these have melanotic tumors. Males raised at 26 and heterozygous females raised at 29 survive to adulthood, but show melanotic masses in the abdominal cavity or small black specks in the legs, wings, or thorax. Mutant larvae kept at 29 show enlargement of the lymph glands in the late second- or early third-instar larvae, but no melanotic masses. By mid third-instar, the lymph glands are large and diffuse and the gastric caeca have become encapsulated and melanized. By late third-instar, the larvae have melanotic masses in the body cavity, lack lymph glands, and have reduced, encapsulated and melanized gastric caeca as well as encapsulated and melanized muscles and fat bodies. These mutants do not survive beyond the late third-instar or the early pupal stage. When lymph glands from Tum larvae are injected into adult female hosts, transplantable neoplasms are produced. Melanization, at first associated with the leg joints and later with the head, thorax, and abdomen, takes place; also abdominal bloating. The lymph glands become melanotic and the abdomen is filled with encapsulated masses before the premature death of the injected individuals. Injection of Tum tissue other than lymph glands fails to produce these effects. The melanotic neoplasms can be transplanted into a succession of hosts in which they produce the same abnormalities. The neoplastic cells resemble hemocytes; some cell lines are melanotic and others are unpigmented, but in both types, the tissue, when transplanted, grows rapidly in the hosts and kills them.
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Description
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FB2012_01
Transgenic Constructs
Sequence features
References
Alleles
FB2011_10
References
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
10B5-10B6  
Limits computationally determined from genome sequence between P{EP}CG11756EP1610 and P{EP}CG32666EP1452  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
10B6-10B6  
(determined by in situ hybridisation)  
10B6-10B6  
(determined by in situ hybridisation)  
Experimentally Determined Recombination Data
Location
1-34.6
 
Left of (cM)
Right of (cM)
Notes
hide Gene Model & Products
Please see the GBrowse view of Dmel\hop for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
detailed view FBtr0073456 FBtr0073457 FBtr0073482 FBtr0073490 FBtr0112813 FBtr0073491 FBtr0073488 FBtr0073483 FBtr0073492 FBpp0073312 FBpp0073313 FBpp0073338 FBti0071723 FBti0024932 FBti0052587 FBti0068320
Comments on Gene Model
DGC clone HL03036 appears problematic: incomplete CDS
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
FBtr0073457
  5085
  1177
Additional Transcript Data & Comments
Reported size (kB)
5.4, 5.1 (northern blot)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
hop-PA  
FBpp0073313  
135.1  
1177  
7.25  
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
hide Mapped Features
Mapped Features have been reorganized, please see this article for details.
Additional mapped features and mutations can be found on GBrowse or related reports.
Type
Symbol & Location
Additional Notes
References
hide External Data
Linkouts
Crossreferences
hide Expression Data
hideTranscript Expression
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
hidePolypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
hide High-Throughput Expression Data
or
Untitled Document detailed view CG11750-RA hop-RA Tim8-RA
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

modENCODE Temporal Expression Data for FBgn0004864


   Styles
Linear
Logarithmic
Heatmap
   Scales
max expr for FBgn0004864
Very low expression bin max
Moderate expression bin max
High expression bin max
Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages.
[download data (TSV)]

Guide to modENCODE expression level colors
 
No expression (0 - 0)
 
Extremely low expression (1 - 10)
 
Very low expression (11 - 100)
 
Low expression (101 - 400)
 
Moderate expression (401 - 1400)
 
Moderately high expression (1401 - 4000)
 
High expression (4001 - 10000)
 
Very high expression (10001 - 100000)
 
Extremely high expression (100001 - 2000000)

Linear, scaled to maximum FBgn0004864 expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 3936
embryo 02-04hr
 
 3608
embryo 04-06hr
 
 2186
embryo 06-08hr
 
 2001
embryo 08-10hr
 
 1972
embryo 10-12hr
 
 1113
embryo 12-14hr
 
 1278
embryo 14-16hr
 
 1345
embryo 16-18hr
 
 993
embryo 18-20hr
 
 761
embryo 20-22hr
 
 768
embryo 22-24hr
 
 819
larva L1
 
 781
larva L2
 
 616
larva L3 12hr old
 
 509
larva L3 puffstage 1-2
 
 538
larva L3 puffstage 3-6
 
 869
larva L3 puffstage 7-9
 
 1027
white prepupae new
 
 1138
white prepupae 12hr
 
 901
white prepupae 24hr
 
 1157
pupae 2d postWPP
 
 855
pupae 3d postWPP
 
 561
pupae 4d postWPP
 
 494
adult male 01day
 
 562
adult male 05day
 
 645
adult male 30day
 
 695
adult female 01day
 
 1520
adult female 05day
 
 2269
adult female 30day
 
 2332
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
Linear, scaled to Very low expression
Developmental Stage   Expression Level
embryo 00-02hr
 (3936)
embryo 02-04hr
 (3608)
embryo 04-06hr
 (2186)
embryo 06-08hr
 (2001)
embryo 08-10hr
 (1972)
embryo 10-12hr
 (1113)
embryo 12-14hr
 (1278)
embryo 14-16hr
 (1345)
embryo 16-18hr
 (993)
embryo 18-20hr
 (761)
embryo 20-22hr
 (768)
embryo 22-24hr
 (819)
larva L1
 (781)
larva L2
 (616)
larva L3 12hr old
 (509)
larva L3 puffstage 1-2
 (538)
larva L3 puffstage 3-6
 (869)
larva L3 puffstage 7-9
 (1027)
white prepupae new
 (1138)
white prepupae 12hr
 (901)
white prepupae 24hr
 (1157)
pupae 2d postWPP
 (855)
pupae 3d postWPP
 (561)
pupae 4d postWPP
 (494)
adult male 01day
 (562)
adult male 05day
 (645)
adult male 30day
 (695)
adult female 01day
 (1520)
adult female 05day
 (2269)
adult female 30day
 (2332)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
Linear, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 (3936)
embryo 02-04hr
 (3608)
embryo 04-06hr
 (2186)
embryo 06-08hr
 (2001)
embryo 08-10hr
 (1972)
embryo 10-12hr
 
 1113
embryo 12-14hr
 
 1278
embryo 14-16hr
 
 1345
embryo 16-18hr
 
 993
embryo 18-20hr
 
 761
embryo 20-22hr
 
 768
embryo 22-24hr
 
 819
larva L1
 
 781
larva L2
 
 616
larva L3 12hr old
 
 509
larva L3 puffstage 1-2
 
 538
larva L3 puffstage 3-6
 
 869
larva L3 puffstage 7-9
 
 1027
white prepupae new
 
 1138
white prepupae 12hr
 
 901
white prepupae 24hr
 
 1157
pupae 2d postWPP
 
 855
pupae 3d postWPP
 
 561
pupae 4d postWPP
 
 494
adult male 01day
 
 562
adult male 05day
 
 645
adult male 30day
 
 695
adult female 01day
 (1520)
adult female 05day
 (2269)
adult female 30day
 (2332)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 3936
embryo 02-04hr
 
 3608
embryo 04-06hr
 
 2186
embryo 06-08hr
 
 2001
embryo 08-10hr
 
 1972
embryo 10-12hr
 
 1113
embryo 12-14hr
 
 1278
embryo 14-16hr
 
 1345
embryo 16-18hr
 
 993
embryo 18-20hr
 
 761
embryo 20-22hr
 
 768
embryo 22-24hr
 
 819
larva L1
 
 781
larva L2
 
 616
larva L3 12hr old
 
 509
larva L3 puffstage 1-2
 
 538
larva L3 puffstage 3-6
 
 869
larva L3 puffstage 7-9
 
 1027
white prepupae new
 
 1138
white prepupae 12hr
 
 901
white prepupae 24hr
 
 1157
pupae 2d postWPP
 
 855
pupae 3d postWPP
 
 561
pupae 4d postWPP
 
 494
adult male 01day
 
 562
adult male 05day
 
 645
adult male 30day
 
 695
adult female 01day
 
 1520
adult female 05day
 
 2269
adult female 30day
 
 2332
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 3936
embryo 02-04hr
 
 3608
embryo 04-06hr
 
 2186
embryo 06-08hr
 
 2001
embryo 08-10hr
 
 1972
embryo 10-12hr
 
 1113
embryo 12-14hr
 
 1278
embryo 14-16hr
 
 1345
embryo 16-18hr
 
 993
embryo 18-20hr
 
 761
embryo 20-22hr
 
 768
embryo 22-24hr
 
 819
larva L1
 
 781
larva L2
 
 616
larva L3 12hr old
 
 509
larva L3 puffstage 1-2
 
 538
larva L3 puffstage 3-6
 
 869
larva L3 puffstage 7-9
 
 1027
white prepupae new
 
 1138
white prepupae 12hr
 
 901
white prepupae 24hr
 
 1157
pupae 2d postWPP
 
 855
pupae 3d postWPP
 
 561
pupae 4d postWPP
 
 494
adult male 01day
 
 562
adult male 05day
 
 645
adult male 30day
 
 695
adult female 01day
 
 1520
adult female 05day
 
 2269
adult female 30day
 
 2332
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
log, scaled to maximum FBgn0004864 expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 3936
embryo 02-04hr
 
 3608
embryo 04-06hr
 
 2186
embryo 06-08hr
 
 2001
embryo 08-10hr
 
 1972
embryo 10-12hr
 
 1113
embryo 12-14hr
 
 1278
embryo 14-16hr
 
 1345
embryo 16-18hr
 
 993
embryo 18-20hr
 
 761
embryo 20-22hr
 
 768
embryo 22-24hr
 
 819
larva L1
 
 781
larva L2
 
 616
larva L3 12hr old
 
 509
larva L3 puffstage 1-2
 
 538
larva L3 puffstage 3-6
 
 869
larva L3 puffstage 7-9
 
 1027
white prepupae new
 
 1138
white prepupae 12hr
 
 901
white prepupae 24hr
 
 1157
pupae 2d postWPP
 
 855
pupae 3d postWPP
 
 561
pupae 4d postWPP
 
 494
adult male 01day
 
 562
adult male 05day
 
 645
adult male 30day
 
 695
adult female 01day
 
 1520
adult female 05day
 
 2269
adult female 30day
 
 2332
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
log, scaled to Very low expression
Developmental Stage   Expression Level
embryo 00-02hr
 (3936)
embryo 02-04hr
 (3608)
embryo 04-06hr
 (2186)
embryo 06-08hr
 (2001)
embryo 08-10hr
 (1972)
embryo 10-12hr
 (1113)
embryo 12-14hr
 (1278)
embryo 14-16hr
 (1345)
embryo 16-18hr
 (993)
embryo 18-20hr
 (761)
embryo 20-22hr
 (768)
embryo 22-24hr
 (819)
larva L1
 (781)
larva L2
 (616)
larva L3 12hr old
 (509)
larva L3 puffstage 1-2
 (538)
larva L3 puffstage 3-6
 (869)
larva L3 puffstage 7-9
 (1027)
white prepupae new
 (1138)
white prepupae 12hr
 (901)
white prepupae 24hr
 (1157)
pupae 2d postWPP
 (855)
pupae 3d postWPP
 (561)
pupae 4d postWPP
 (494)
adult male 01day
 (562)
adult male 05day
 (645)
adult male 30day
 (695)
adult female 01day
 (1520)
adult female 05day
 (2269)
adult female 30day
 (2332)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
log, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 (3936)
embryo 02-04hr
 (3608)
embryo 04-06hr
 2186
embryo 06-08hr
 2001
embryo 08-10hr
 1972
embryo 10-12hr
 
 1113
embryo 12-14hr
 
 1278
embryo 14-16hr
 
 1345
embryo 16-18hr
 
 993
embryo 18-20hr
 
 761
embryo 20-22hr
 
 768
embryo 22-24hr
 
 819
larva L1
 
 781
larva L2
 
 616
larva L3 12hr old
 
 509
larva L3 puffstage 1-2
 
 538
larva L3 puffstage 3-6
 
 869
larva L3 puffstage 7-9
 
 1027
white prepupae new
 
 1138
white prepupae 12hr
 
 901
white prepupae 24hr
 
 1157
pupae 2d postWPP
 
 855
pupae 3d postWPP
 
 561
pupae 4d postWPP
 
 494
adult male 01day
 
 562
adult male 05day
 
 645
adult male 30day
 
 695
adult female 01day
 1520
adult female 05day
 2269
adult female 30day
 2332
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 3936
embryo 02-04hr
 
 3608
embryo 04-06hr
 
 2186
embryo 06-08hr
 
 2001
embryo 08-10hr
 
 1972
embryo 10-12hr
 
 1113
embryo 12-14hr
 
 1278
embryo 14-16hr
 
 1345
embryo 16-18hr
 
 993
embryo 18-20hr
 
 761
embryo 20-22hr
 
 768
embryo 22-24hr
 
 819
larva L1
 
 781
larva L2
 
 616
larva L3 12hr old
 
 509
larva L3 puffstage 1-2
 
 538
larva L3 puffstage 3-6
 
 869
larva L3 puffstage 7-9
 
 1027
white prepupae new
 
 1138
white prepupae 12hr
 
 901
white prepupae 24hr
 
 1157
pupae 2d postWPP
 
 855
pupae 3d postWPP
 
 561
pupae 4d postWPP
 
 494
adult male 01day
 
 562
adult male 05day
 
 645
adult male 30day
 
 695
adult female 01day
 
 1520
adult female 05day
 
 2269
adult female 30day
 
 2332
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 3936
embryo 02-04hr
 
 3608
embryo 04-06hr
 
 2186
embryo 06-08hr
 
 2001
embryo 08-10hr
 
 1972
embryo 10-12hr
 
 1113
embryo 12-14hr
 
 1278
embryo 14-16hr
 
 1345
embryo 16-18hr
 
 993
embryo 18-20hr
 
 761
embryo 20-22hr
 
 768
embryo 22-24hr
 
 819
larva L1
 
 781
larva L2
 
 616
larva L3 12hr old
 
 509
larva L3 puffstage 1-2
 
 538
larva L3 puffstage 3-6
 
 869
larva L3 puffstage 7-9
 
 1027
white prepupae new
 
 1138
white prepupae 12hr
 
 901
white prepupae 24hr
 
 1157
pupae 2d postWPP
 
 855
pupae 3d postWPP
 
 561
pupae 4d postWPP
 
 494
adult male 01day
 
 562
adult male 05day
 
 645
adult male 30day
 
 695
adult female 01day
 
 1520
adult female 05day
 
 2269
adult female 30day
 
 2332
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
Heatmap
Developmental Stage   Expression Level
embryo 00-02hr
 
 
embryo 02-04hr
 
 
embryo 04-06hr
 
 
embryo 06-08hr
 
 
embryo 08-10hr
 
 
embryo 10-12hr
 
 
embryo 12-14hr
 
 
embryo 14-16hr
 
 
embryo 16-18hr
 
 
embryo 18-20hr
 
 
embryo 20-22hr
 
 
embryo 22-24hr
 
 
larva L1
 
 
larva L2
 
 
larva L3 12hr old
 
 
larva L3 puffstage 1-2
 
 
larva L3 puffstage 3-6
 
 
larva L3 puffstage 7-9
 
 
white prepupae new
 
 
white prepupae 12hr
 
 
white prepupae 24hr
 
 
pupae 2d postWPP
 
 
pupae 3d postWPP
 
 
pupae 4d postWPP
 
 
adult male 01day
 
 
adult male 05day
 
 
adult male 30day
 
 
adult female 01day
 
 
adult female 05day
 
 
adult female 30day
 
 

FlyAtlas Anatomical Expression Data for FBgn0004864


   Styles
Linear
Logarithmic
Heatmap
Back-to-back
   Scales
max expr for FBgn0004864
Moderate expression bin max
High level expression bin max
Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass.
[download data (TSV)]

Guide to FlyAtlas expression level colors
 
No expression (0 - 9.999)
 
Low expression (10 - 99.999)
 
Moderate expression (100 - 499.999)
 
High level expression (500 - 999.999)
 
Very high expression (1000 - 25000)

Linear, scaled to maximum FBgn0004864 expression level
Tissue   Expression Level
Larval Central Nervous System
 
 289.425
Larval Midgut
 
 181.2
Larval Hindgut
 
 218
Larval Malpighian Tubules
 
 215
Larval Fat Body
 
 195.6
Larval Salivary Gland
 
 471.2
Larval Trachea
 
 242.275
Larval Carcass
 
 218.25
Adult Head
 
 127.4
Adult Eye
 
 157.75
Adult Brain
 
 233.8
Adult Thoracic-Abdominal Ganglion
 
 186
Adult Crop
 
 191.6
Adult Midgut
 
 190
Adult Hindgut
 
 157.6
Adult Malpighian Tubules
 
 193
Adult Fat Body
 
 163.1
Adult Salivary Gland
 
 307.4
Adult Heart
 
 143.275
Adult VirginFemale Spermatheca
 
 185.1
Adult InseminatedFemale Spermatheca
 
 217.7
Adult Ovary
 
 286.1
Adult Testis
 
 28.7
Adult Male Accessory Gland
 
 297.3
Adult Carcass
 
 127.8
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
Linear, scaled to Moderate expression
Tissue   Expression Level
Larval Central Nervous System
 
 289.425
Larval Midgut
 
 181.2
Larval Hindgut
 
 218
Larval Malpighian Tubules
 
 215
Larval Fat Body
 
 195.6
Larval Salivary Gland
 
 471.2
Larval Trachea
 
 242.275
Larval Carcass
 
 218.25
Adult Head
 
 127.4
Adult Eye
 
 157.75
Adult Brain
 
 233.8
Adult Thoracic-Abdominal Ganglion
 
 186
Adult Crop
 
 191.6
Adult Midgut
 
 190
Adult Hindgut
 
 157.6
Adult Malpighian Tubules
 
 193
Adult Fat Body
 
 163.1
Adult Salivary Gland
 
 307.4
Adult Heart
 
 143.275
Adult VirginFemale Spermatheca
 
 185.1
Adult InseminatedFemale Spermatheca
 
 217.7
Adult Ovary
 
 286.1
Adult Testis
 
 28.7
Adult Male Accessory Gland
 
 297.3
Adult Carcass
 
 127.8
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
Linear, scaled to High level expression
Tissue   Expression Level
Larval Central Nervous System
 
 289.425
Larval Midgut
 
 181.2
Larval Hindgut
 
 218
Larval Malpighian Tubules
 
 215
Larval Fat Body
 
 195.6
Larval Salivary Gland
 
 471.2
Larval Trachea
 
 242.275
Larval Carcass
 
 218.25
Adult Head
 
 127.4
Adult Eye
 
 157.75
Adult Brain
 
 233.8
Adult Thoracic-Abdominal Ganglion
 
 186
Adult Crop
 
 191.6
Adult Midgut
 
 190
Adult Hindgut
 
 157.6
Adult Malpighian Tubules
 
 193
Adult Fat Body
 
 163.1
Adult Salivary Gland
 
 307.4
Adult Heart
 
 143.275
Adult VirginFemale Spermatheca
 
 185.1
Adult InseminatedFemale Spermatheca
 
 217.7
Adult Ovary
 
 286.1
Adult Testis
 
 28.7
Adult Male Accessory Gland
 
 297.3
Adult Carcass
 
 127.8
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Linear, scaled to Very high expression
Tissue   Expression Level
Larval Central Nervous System
 
 289.425
Larval Midgut
 
 181.2
Larval Hindgut
 
 218
Larval Malpighian Tubules
 
 215
Larval Fat Body
 
 195.6
Larval Salivary Gland
 
 471.2
Larval Trachea
 
 242.275
Larval Carcass
 
 218.25
Adult Head
 
 127.4
Adult Eye
 
 157.75
Adult Brain
 
 233.8
Adult Thoracic-Abdominal Ganglion
 
 186
Adult Crop
 
 191.6
Adult Midgut
 
 190
Adult Hindgut
 
 157.6
Adult Malpighian Tubules
 
 193
Adult Fat Body
 
 163.1
Adult Salivary Gland
 
 307.4
Adult Heart
 
 143.275
Adult VirginFemale Spermatheca
 
 185.1
Adult InseminatedFemale Spermatheca
 
 217.7
Adult Ovary
 
 286.1
Adult Testis
 
 28.7
Adult Male Accessory Gland
 
 297.3
Adult Carcass
 
 127.8
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to maximum FBgn0004864 expression level
Tissue   Expression Level
Larval Central Nervous System
 
 289.425
Larval Midgut
 
 181.2
Larval Hindgut
 
 218
Larval Malpighian Tubules
 
 215
Larval Fat Body
 
 195.6
Larval Salivary Gland
 
 471.2
Larval Trachea
 
 242.275
Larval Carcass
 
 218.25
Adult Head
 
 127.4
Adult Eye
 
 157.75
Adult Brain
 
 233.8
Adult Thoracic-Abdominal Ganglion
 
 186
Adult Crop
 
 191.6
Adult Midgut
 
 190
Adult Hindgut
 
 157.6
Adult Malpighian Tubules
 
 193
Adult Fat Body
 
 163.1
Adult Salivary Gland
 
 307.4
Adult Heart
 
 143.275
Adult VirginFemale Spermatheca
 
 185.1
Adult InseminatedFemale Spermatheca
 
 217.7
Adult Ovary
 
 286.1
Adult Testis
 
 28.7
Adult Male Accessory Gland
 
 297.3
Adult Carcass
 
 127.8
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
log, scaled to Moderate expression
Tissue   Expression Level
Larval Central Nervous System
 
 289.425
Larval Midgut
 
 181.2
Larval Hindgut
 
 218
Larval Malpighian Tubules
 
 215
Larval Fat Body
 
 195.6
Larval Salivary Gland
 
 471.2
Larval Trachea
 
 242.275
Larval Carcass
 
 218.25
Adult Head
 
 127.4
Adult Eye
 
 157.75
Adult Brain
 
 233.8
Adult Thoracic-Abdominal Ganglion
 
 186
Adult Crop
 
 191.6
Adult Midgut
 
 190
Adult Hindgut
 
 157.6
Adult Malpighian Tubules
 
 193
Adult Fat Body
 
 163.1
Adult Salivary Gland
 
 307.4
Adult Heart
 
 143.275
Adult VirginFemale Spermatheca
 
 185.1
Adult InseminatedFemale Spermatheca
 
 217.7
Adult Ovary
 
 286.1
Adult Testis
 
 28.7
Adult Male Accessory Gland
 
 297.3
Adult Carcass
 
 127.8
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
log, scaled to High level expression
Tissue   Expression Level
Larval Central Nervous System
 
 289.425
Larval Midgut
 
 181.2
Larval Hindgut
 
 218
Larval Malpighian Tubules
 
 215
Larval Fat Body
 
 195.6
Larval Salivary Gland
 
 471.2
Larval Trachea
 
 242.275
Larval Carcass
 
 218.25
Adult Head
 
 127.4
Adult Eye
 
 157.75
Adult Brain
 
 233.8
Adult Thoracic-Abdominal Ganglion
 
 186
Adult Crop
 
 191.6
Adult Midgut
 
 190
Adult Hindgut
 
 157.6
Adult Malpighian Tubules
 
 193
Adult Fat Body
 
 163.1
Adult Salivary Gland
 
 307.4
Adult Heart
 
 143.275
Adult VirginFemale Spermatheca
 
 185.1
Adult InseminatedFemale Spermatheca
 
 217.7
Adult Ovary
 
 286.1
Adult Testis
 
 28.7
Adult Male Accessory Gland
 
 297.3
Adult Carcass
 
 127.8
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to Very high expression
Tissue   Expression Level
Larval Central Nervous System
 
 289.425
Larval Midgut
 
 181.2
Larval Hindgut
 
 218
Larval Malpighian Tubules
 
 215
Larval Fat Body
 
 195.6
Larval Salivary Gland
 
 471.2
Larval Trachea
 
 242.275
Larval Carcass
 
 218.25
Adult Head
 
 127.4
Adult Eye
 
 157.75
Adult Brain
 
 233.8
Adult Thoracic-Abdominal Ganglion
 
 186
Adult Crop
 
 191.6
Adult Midgut
 
 190
Adult Hindgut
 
 157.6
Adult Malpighian Tubules
 
 193
Adult Fat Body
 
 163.1
Adult Salivary Gland
 
 307.4
Adult Heart
 
 143.275
Adult VirginFemale Spermatheca
 
 185.1
Adult InseminatedFemale Spermatheca
 
 217.7
Adult Ovary
 
 286.1
Adult Testis
 
 28.7
Adult Male Accessory Gland
 
 297.3
Adult Carcass
 
 127.8
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Heatmap
Tissue   Expression Level
Larval Central Nervous System
 
 
Larval Midgut
 
 
Larval Hindgut
 
 
Larval Malpighian Tubules
 
 
Larval Fat Body
 
 
Larval Salivary Gland
 
 
Larval Trachea
 
 
Larval Carcass
 
 
Adult Head
 
 
Adult Eye
 
 
Adult Brain
 
 
Adult Thoracic-Abdominal Ganglion
 
 
Adult Crop
 
 
Adult Midgut
 
 
Adult Hindgut
 
 
Adult Malpighian Tubules
 
 
Adult Fat Body
 
 
Adult Salivary Gland
 
 
Adult Heart
 
 
Adult VirginFemale Spermatheca
 
 
Adult InseminatedFemale Spermatheca
 
 
Adult Ovary
 
 
Adult Testis
 
 
Adult Male Accessory Gland
 
 
Adult Carcass
 
 

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level Tissue Adult Expression Level
 
NA 
Head
 
 127.4
 
NA 
Eye
 
 157.75
 
NA 
Brain
 
 233.8
 
289.425 
Central Nervous System
 
 NA
 
NA 
Thoracic-Abdominal Ganglion
 
 186
 
NA 
Crop
 
 191.6
 
181.2 
Midgut
 
 190
 
218 
Hindgut
 
 157.6
 
215 
Malpighian Tubules
 
 193
 
195.6 
Fat Body
 
 163.1
 
471.2 
Salivary Gland
 
 307.4
 
NA 
Heart
 
 143.275
 
242.275 
Trachea
 
 NA
 
NA 
VirginFemale Spermatheca
 
 185.1
 
NA 
InseminatedFemale Spermatheca
 
 217.7
 
NA 
Ovary
 
 286.1
 
NA 
Testis
 
 28.7
 
NA 
Male Accessory Gland
 
 297.3
 
218.25 
Carcass
 
 127.8

modENCODE Temporal Expression Data (Graveley et al., 2011)
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
hide Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
hide External Data & Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
hide Alleles & Phenotypes
hide Summary of Allele Phenotypes
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
hindgut & nucleus
hindgut & nucleus, with Scer\GAL4hs.PB
hide Classical Alleles ( 54 )
For All Classical Alleles Show

Allele of hopClassMutagenStocksKnown lesion
hop2loss of function allele, amorphic allele - genetic evidence2 Yes
hopTumneomorphic allele - genetic evidence, gain of function allele2 Yes
hop27amorphic allele - genetic evidence1 Yes
hop3amorphic allele - genetic evidence1 Yes
hop25hypomorphic allele - genetic evidence1 Yes
hopGG01333
1 --
hopKG019901 --
hop12amorphic allele - genetic evidence0 Yes
hop13amorphic allele - genetic evidence0 Yes
hop14amorphic allele - genetic evidence0 Yes
hop15amorphic allele - genetic evidence0 --
hop16amorphic allele - genetic evidence0 --
hop1amorphic allele - genetic evidence0 --
hop29amorphic allele - genetic evidence0 Yes
hop32amorphic allele - genetic evidence0 Yes
hop33amorphic allele - genetic evidence0 --
hop34amorphic allele - genetic evidence0 Yes
hop35amorphic allele - genetic evidence0 --
hop4amorphic allele - genetic evidence0 Yes
hop9amorphic allele - genetic evidence0 Yes
hop100 --
hop110 --
hop170 --
hop180 --
hop190 --
hop200 Yes
hop210 --
hop220 --
hop230 --
hop240 --
hop260 --
hop280 --
hop300 --
hop310 --
hop50 --
hop60 --
hop70 --
hop80 --
hopairloss of function allele0 --
hopF1.1
0 Yes
hopJ1A.1
0 Yes
hopM6370 Yes
hopM637rev10 --
hopr1loss of function allele0 --
hopr2loss of function allele0 --
hopr3loss of function allele0 --
hopr4loss of function allele0 --
hopr5loss of function allele0 --
hopT-r70 --
hopT420 Yes
hopunspecified
0 --
hopX-139-30 --
hopX-170-250 --
hopX-82-360 --
hide Alleles Carried on Transgenic Constructs ( 23 )
For All Alleles Carried on Transgenic Constructs Show

Allele of hopClassMutagenStocksKnown lesion
hopGD91571 Yes
hopGL003051 Yes
hopHMS007611 Yes
hopJF012671 Yes
hopJF012681 Yes
hopKK1051361 Yes
hopAct5C.PH0 Yes
hopAct5C.PK0 Yes
hopAct5C.PY0 Yes
hopAct5C.T:Hsap\MYC0 Yes
hopdsRNA.Scer\UAS.cCa0 Yes
hopdsRNA.Scer\UAS.cMa0 Yes
hophs.PB0 Yes
hophs.PH0 Yes
hopMtnA.T:SV5\V50 Yes
hopScer\UAS.cHa0 Yes
hopT-r7.Act5C0 Yes
hopT42.Act5C0 Yes
hopTum.Act5C0 Yes
hopTum.hs0 Yes
hopTum.Scer\UAS0 Yes
hopTumL.Act5C0 Yes
hopΔJH2.Act5C0 Yes
hide Aneuploid Aberrations
Duplicated in
Not disrupted in
Not duplicated in
Disrupted in
hide Transgenic Constructs & Insertions
Transgenic Constructs
Type of construct
Name
Expression data
heat-shock construct
characterization construct
Insertions
Type of insertions
Name
Expression data
miscellaneous insertions
insertion of mobile activating element
hide Gene Ontology: Function, Process & Cellular Component ( 51 unique terms )
hide Terms Based on Experimental Evidence ( 28 terms )
Molecular Function ( 0 terms)
Biological Process
CV term
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with Stat92E AND inferred from sequence or structural similarity
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
Cellular Component ( 0 terms)
hide Terms Based on Predictions or Assertions ( 26 terms )
Molecular Function
CV term
References
inferred from sequence or structural similarity with human JAK1
inferred from sequence or structural similarity with mouse Jak2
non-traceable author statement
traceable author statement
Biological Process
CV term
References
traceable author statement
non-traceable author statement
traceable author statement
traceable author statement
non-traceable author statement
traceable author statement
Cellular Component
CV term
References
non-traceable author statement
traceable author statement
inferred from electronic annotation with InterPro:IPR000299
hide Sequence Ontology: Class of Gene
hide Interactions & Pathways
hide Summary of Physical Interactions
Protein-protein
Interacting group
Assay
References
hide Summary of Genetic Interactions
Interacts with
Please look at the allele data for full details of the genetic interactions
hop allele
Gene
References
hide External Data
Linkouts
BioGRID - A database of protein and genetic interactions
DPiM - DPiM, Drosophila Protein interaction Map
DroID - A comprehensive database of gene and protein interactions.
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
hide Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs
Linkouts
InParanoid A subset of ortholog calls from InParanoid.
OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs.
hide Stocks & Reagents
hide Stocks Listed in FlyBase ( 15 )
Bloomington
Kyoto
108563
VDRC
hide Genomic Clones ( 2 )
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
hide cDNA Clones ( 29 )
Please Note
This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
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Linkouts
DRSC - Results from RNAi screens.
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Source for database identity of
Source for identity of: hop CG1594
Source for database merge of
Additional comments
Identified by PCR fragment; relationship to other protein tyrosine kinase genes not known.
hide Other Comments
hop is required for os-induced Stat92E phosphorylation.
Treatment of S2-derived S2-NP cells with dsRNA made from templates generated with primers directed against hop results in a 12-24-fold decrease in JAK/STAT activity.
When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of G1 phase cells is seen.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Stat92E is part of an intracellular Jak-Stat signalling pathway and is activated by the hop Jak kinase. Partial loss of hop gene product activity gives a phenotype similar to that of Stat92E mutants, supporting the idea that the Jak-Stat pathway is involved in regulation of oogenesis.
phl acts downstream of hop during differentiation of lamellocytes in larvae.
hop is required for the renewal of male germline stem cells and for maintenance of the somatic cyst progenitor cell population in the testis.
hop is required for cell proliferation/survival in the eye imaginal disc, for the differentiation of photoreceptor cells, and for the establishment of the equator and of ommatidial polarity.
Candidate gene for testicular atrophy quantitative trait locus.
Dominant hop mutations cause hop to be a hyperactive kinase that can cause hyperactivation of the hop Stat92E pathway.
Phylogenetic analysis of the PTK family.
The hop kinase acts upstream of Stat92E in the JAK/STAT pathway. hop may activate Stat92E to regulate transcription of target genes such as eve. Stat92E is epistatic to hop.
A mutation in Stat92E has been identified by suppression of a hop mutant phenotype.
An allele of Stat92E was identified in a screen for second site suppressors of hopTum.
Mutations in Jak kinase, hop, can cause leukaemia-like abnormalities.
hop is an example of a maternally provided nonreceptor tyrosine kinase involved in segmentation of embryos. hop has a zygotic role in cellular proliferation.
Mutants display neoplastic phenotype.
hop is required for cell division and proper embryonic segmentation.
Identification: Identified by PCR fragment; relationship to other protein tyrosine kinase genes not known.
Most of the mutants are homozygous late zygotic (L-P) lethals; one mutant is a larval lethal; two other mutants have some adult survivors (hemizygous males being morphologically normal, but 40% of the homozygous females and 85% of the hemizygous females showing major defects). Heteroallelic females are lethal with the exceptions noted under the alleles. There is a maternal effect on thoracic and abdominal segments, the most extreme embryos <up>produced from homozygous "l(1)hop" germ-line clones that have not received a paternal copy of hop+</up> showing defects in the posterior spiracles and in segments T2 (denticle belt deleted). T3, A4 and A5 (segment missing) and A8 (segment reduced in size); the least extreme mutant embryos from germ-line clones show defects in segment A5. Defects visible in early segmentation stages. The extent of the defects is dependent on the strength of the maternal alleles and the paternal contribution. Wild-type sperm can rescue all defects, except those in A5. A few of the rescued progeny hatch and develop into adults.
The wild-type allele of hop is required for the continued cell division of all diploid cells as well as the establishment of the normal array of segments.
hop is dosage compensated. All viable heteroallelic combinations are female sterile, failing to produce eggs or laying abnormal eggs that are small, with a clear chorion and with chorionic filaments absent or partially fused.
hide External Crossreferences & Linkouts
Sequence Crossreferences
RefSeq (Transcripts)
RefSeq (Proteins)
Entrez Gene - A searchable database of RefSeq genes.
Other Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
Linkouts
BioGRID - A database of protein and genetic interactions
DPiM - DPiM, Drosophila Protein interaction Map
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results from RNAi screens.
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
InParanoid A subset of ortholog calls from InParanoid.
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
modMine - Data generated by the modENCODE project.
OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs.
hide Synonyms & Secondary IDs ( 29 )
Reported As
Symbol Synonym
HD-160
 
hop
(Rehwinkel et al., 2006, Ekas et al., 2006, Minakhina and Steward, 2006, Jang and Montell, 2007, Shen and Tanda, 2007, Yasugi et al., 2007, Guo and Harrison, 2007, Hombria et al., 2005, Tsai and Sun, 2004, Brun et al., 2006, Krzemien et al., 2007, Gao et al., 2009, Kleino et al., 2008, Copf et al., 2011, Bach et al., 2007, Munier et al., 2002, Tokusumi et al., 2009, Yan et al., 2011, Han and Harrison, 2008, Copf and Preat, 2008, Baeg et al., 2007, Assa-Kunik et al., 2007, Yamashita et al., 2005, Xing et al., 2007, Ayala-Camargo et al., 2007, Wawersik et al., 2005, Starz-Gaiano et al., 2008, López-Onieva et al., 2008, Yasugi et al., 2008, Sorrentino et al., 2007, Tsai et al., 2007, Avila and Erickson, 2007, Kwon et al., 2008, Shi et al., 2008, Sotillos et al., 2008, Rawlings et al., 2004, Almudi et al., 2009, Buchon et al., 2009, Xie et al., 2005, Habayeb et al., 2009, Kwon et al., 2009, Buchon et al., 2009, Flaherty et al., 2009, Tokusumi et al., 2009, Jiang et al., 2009, Zeitlinger et al., 2007, Shi et al., 2006, Rehwinkel et al., 2005, Bertet et al., 2009, Oishi et al., 2006, Hill-Burns and Clark, 2009, Sinenko and Mathey-Prevot, 2004, Obbard et al., 2009, Popodi et al., 2010-, Gutierrez-Aviño et al., 2009, Beebe et al., 2010, Sotillos et al., 2010, Wertheim et al., 2005, Lin et al., 2010, Leatherman and DiNardo, 2008, Jacques et al., 2009, Ekas et al., 2010, Reddy et al., 2010, Kallio et al., 2010, Beltran et al., 2007, Mukherjee et al., 2005, Novakova and Dolezal, 2011, Jiang et al., 2011, Pastor-Pareja et al., 2008, Liu et al., 2010, Wright et al., 2011, Vidal et al., 2010, Makki et al., 2010)
l(1)G18
 
msvl
 
Name Synonym
JAK kinase
Janus-family kinase
Tumorous
 
Secondary FlyBase IDs
  • FBgn0001211
  • FBgn0003895
  • FBgn0022799
hide References ( 376 )
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hide Recent research papers ( 21 )
Booker et al., 2011, BMC Genomics 12: 50
False negative rates in Drosophila cell-based RNAi screens: a case study. [FBrf0212969]
Copf et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(19): 8059--8064
Cytokine signaling through the JAK/STAT pathway is required for long-term memory in Drosophila. [FBrf0213703]
Jiang et al., 2011, Cell Stem Cell 8(1): 84--95
EGFR/Ras/MAPK Signaling Mediates Adult Midgut Epithelial Homeostasis and Regeneration in Drosophila. [FBrf0212694]
Minakhina et al., 2011, Dev. Biol. 352(2): 308--316
JAK/STAT and the GATA factor Pannier control hemocyte maturation and differentiation in Drosophila. [FBrf0213300]
Novakova and Dolezal, 2011, PLoS ONE 6(3): e17741
Expression of Drosophila Adenosine Deaminase in Immune Cells during Inflammatory Response. [FBrf0213278]
Richter et al., 2011, Nat. Cell Biol. 13(9): 1029--1039
The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements. [FBrf0215050]
Wright et al., 2011, Cell. Signal. 23(5): 920--927
Differential activities of the Drosophila JAK/STAT pathway ligands Upd, Upd2 and Upd3. [FBrf0213113]
Xu et al., 2011, Dev. Biol. 354(1): 31--43
EGFR, Wingless and JAK/STAT signaling cooperatively maintain Drosophila intestinal stem cells. [FBrf0213634]
Yan et al., 2011, FASEB J. 25(1): 232--241
Unphosphorylated STAT and heterochromatin protect genome stability. [FBrf0212715]
Beebe et al., 2010, Dev. Biol. 338(1): 28--37
JAK/STAT signaling coordinates stem cell proliferation and multilineage differentiation in the Drosophila intestinal stem cell lineage. [FBrf0209772]
Bina et al., 2010, EMBO Rep. 11(3): 201--207
Transcriptional targets of Drosophila JAK/STAT pathway signalling as effectors of haematopoietic tumour formation. [FBrf0210131]
Ekas et al., 2010, Dev. Biol. 344(2): 621--636
Characterization of a dominant-active STAT that promotes tumorigenesis in Drosophila. [FBrf0211400]
Kallio et al., 2010, FASEB J. 24(11): 4467--4479
Eye transformer is a negative regulator of Drosophila JAK/STAT signaling. [FBrf0212202]
Karpowicz et al., 2010, Development 137(24): 4135--4145
The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration. [FBrf0212383]
Lin et al., 2010, J. Mol. Cell. Biol. 2(1): 37--49
Paracrine Unpaired Signaling through the JAK/STAT Pathway Controls Self-renewal and Lineage Differentiation of Drosophila Intestinal Stem Cells. [FBrf0209721]
Liu et al., 2010, J. Cell. Biochem. 109(5): 992--999
JAK-STAT is restrained by Notch to control cell proliferation of the Drosophila intestinal stem cells. [FBrf0210433]
Makki et al., 2010, PLoS Biol. 8(8): e1000441
A short receptor downregulates Jak/STAT signalling to control the Drosophila cellular immune response. [FBrf0211466]
Paddibhatla et al., 2010, PLoS Pathog. 6(12): e1001234
Role for sumoylation in systemic inflammation and immune homeostasis in Drosophila larvae. [FBrf0212643]
Reddy et al., 2010, Development 137(14): 2397--2408
Influence of fat-hippo and notch signaling on the proliferation and differentiation of Drosophila optic neuroepithelia. [FBrf0211109]
Sotillos et al., 2010, Dev. Biol. 340(2): 571--582
An efficient approach to isolate STAT regulated enhancers uncovers STAT92E fundamental role in Drosophila tracheal development. [FBrf0210508]
Vidal et al., 2010, J. Cell Sci. 123(20): 3457--3466
Negative regulation of Drosophila JAK-STAT signalling by endocytic trafficking. [FBrf0211993]
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