• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\hop

General Information
Symbol	Dmel\hop	Species	D. melanogaster
Name	hopscotch	Annotation symbol	CG1594
Feature type	protein_coding_gene	FlyBase ID	FBgn0004864
Gene Model Status	Current	Stock availability	15 publicly available
Also Known As	JAK, DmHD-160, l(1)hop, Tum, 4
Genomic Location
Chromosome (arm)	X	Recombination map	1-34.6
Cytogenetic map	10B5-10B6	Sequence location	X:11,254,932..11,262,130 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene hopscotch is referred to in FlyBase by the symbol Dmel\hop (CG1594, FBgn0004864). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: protein tyrosine kinase activity. There is experimental evidence for 28 unique biological process terms, many of which group under: anatomical structure development; biological regulation; sensory organ development; cellular process involved in reproduction; regulation of developmental process; cellular component organization or biogenesis; organ morphogenesis; embryonic pattern specification; multicellular organismal reproductive process; establishment of planar polarity. 77 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; female germline cyst; abdominal ventral denticle belt; hemocyte; external compound sense organ; embryonic/larval hemocoel; adult segment; podocyte; non-connected developing system. It has one annotated transcript and one annotated polypeptide. Protein features are: Band 4.1 domain; FERM domain; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; SH2 motif; Serine-threonine/tyrosine-protein kinase; Tyrosine-protein kinase, active site; Tyrosine-protein kinase, catalytic domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1639072_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of hop. Gene sequence location is X:11254932..11262130.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	hop: hopscotch The wild-type allele of hop is required for the continued cell division of all diploid cells as well as the establishment of the normal array of segments. Most of the mutants are homozygous late zygotic (L-P) lethals; one mutant is a larval lethal; two other mutants have some adult survivors (hemizygous males being morphologaically normal, but 40% of the homzygous females and 85% of the hemizygous females showing major defects). Most of the heteroallelic females are lethal, with the following exceptions: genotype percent viable ____________________________ hop29/hop25 12% hop3/hop25 16% hop14/hop25 40% hop12/hop25 68% hop27/hop25 100% hop32/hop25 100% hop33/hop25 100% All viable heteroallelic combinations are female sterile, failing to produce eggs or laying abnormal eggs that are small, with a clear chorion and with chorionic filaments absent or partially fused (Perrimon and Mahowald, 1986a). There is a maternal effect on thoracic and abdominal segments, the most extreme embryos [produced from homozygous l(1)hop germline clones that have not received a paternal copy of hop+] showing defects in the posterior spiracles and in segments T2 (denticle belt deleted). T3, A4, and A5 (segment missing) and A8 (segment reduced in size); the least extreme mutant embryos from germline clones show defects in segment A5. Defects visible in early segmentation stages. The extent of the defects is dependent on the strength of the maternal alleles and the paternal contribution. Wild-type sperm can rescue all defects, except those in A5. A few of the rescued progeny hatch and develop into adults. Tum: Tumorous Dominant tumorous gene that is a temperature-sensitive lethal at 29 in hemizygous males and homozygous females; about two-thirds of the hemizygous males survive at 18 and one-quarter of these have melanotic tumors. Males raised at 26 and heterozygous females raised at 29 survive to adulthood, but show melanotic masses in the abdominal cavity or small black specks in the legs, wings, or thorax. Mutant larvae kept at 29 show enlargement of the lymph glands in the late second- or early third-instar larvae, but no melanotic masses. By mid third-instar, the lymph glands are large and diffuse and the gastric caeca have become encapsulated and melanized. By late third-instar, the larvae have melanotic masses in the body cavity, lack lymph glands, and have reduced, encapsulated and melanized gastric caeca as well as encapsulated and melanized muscles and fat bodies. These mutants do not survive beyond the late third-instar or the early pupal stage. When lymph glands from Tum larvae are injected into adult female hosts, transplantable neoplasms are produced. Melanization, at first associated with the leg joints and later with the head, thorax, and abdomen, takes place; also abdominal bloating. The lymph glands become melanotic and the abdomen is filled with encapsulated masses before the premature death of the injected individuals. Injection of Tum tissue other than lymph glands fails to produce these effects. The melanotic neoplasms can be transplanted into a succession of hosts in which they produce the same abnormalities. The neoplastic cells resemble hemocytes; some cell lines are melanotic and others are unpigmented, but in both types, the tissue, when transplanted, grows rapidly in the hosts and kills them.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Transgenic Constructs P{UAS-hop.dsRNA.M} Sequence features BKN50850 HFA20340 BKN24272 BKN50818 References Richter et al., 2011, Nat. Cell Biol. 13(9): 1029--1039 Minakhina et al., 2011, Dev. Biol. 352(2): 308--316 Makki et al., 2010, PLoS Biol. 8(8): e1000441 Alleles hop[dsRNA.Scer\UAS.cMa]
FB2011_10	References Vidal et al., 2010, J. Cell Sci. 123(20): 3457--3466
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 10B5-10B6   Limits computationally determined from genome sequence between P{EP}CG11756EP1610 and P{EP}CG32666EP1452
Experimentally Determined Cytological Location
Cytogenetic map Notes References 10B6-10B6   (determined by in situ hybridisation)   (Dearolf, 1993) 10B6-10B6   (determined by in situ hybridisation)   (Binari and Perrimon, 1991)
Experimentally Determined Recombination Data
Location	1-34.6   1-34.61 (Geer et al., 1983, Perrimon and Mahowald, 1986, Binari and Perrimon, 1994)
Left of (cM)	dlg1 (Perrimon and Mahowald, 1986, Binari and Perrimon, 1994)
Right of (cM)	dsh (Perrimon and Mahowald, 1986, Binari and Perrimon, 1994)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\hop for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	DGC clone HL03036 appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) hop-RA FBtr0073457  NM_078564   5085   1177
Additional Transcript Data & Comments
Reported size (kB)	5.4, 5.1 (northern blot) (Binari and Perrimon, 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein hop-PA   FBpp0073313   135.1   1177   7.25     NP_511119   AAF48035
Additional Polypeptide Data & Comments
Reported size (kDa)	1177 (aa) (Binari and Perrimon, 1994)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • FERM domain (IPR000299) Protein kinase, catalytic domain (IPR000719) SH2 motif (IPR000980) Tyrosine-protein kinase, active site (IPR008266) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Band 4.1 domain (IPR019749) Tyrosine-protein kinase, catalytic domain (IPR020635) Serine-threonine/tyrosine-protein kinase (IPR001245)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA697717   AA990624   AE014298 AAF48035   AJ002915 CAA05750   AJ569571   AJ569572   AJ569573   AJ569574   AJ569575   AJ569576   AJ569577   AJ569579   AJ569580   AJ569581   AJ569582   AJ569583   AJ569584   AJ569585   AJ569586   AJ569587   AJ569588   AJ569590   AJ569591   AJ569592   AJ569593   AJ569594   AJ569595   AW941430   AY070869 AAL48491   BF501913   BI165621   BI573881   BI608797   BI617608   BT006331 AAP20030   BZ665584   CO188668   CO263348   CO277895   CO283349   CO318517   CO331723   CO340394   EC051512   EC051534   EC054991   EC072192   EC085193   EC195313   EC208438   EC211225   EC234480   EC245354   EC250158   EC254618   EV576193   GH912676   L26975 AAA62441
UniProtKB/Swiss-Prot	Q24592
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early     (Binari and Perrimon, 1994) embryonic stage -- adult stage     (Binari and Perrimon, 1994)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0004864    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0004864 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0004864 expression level Developmental Stage   Expression Level embryo 00-02hr    3936 embryo 02-04hr    3608 embryo 04-06hr    2186 embryo 06-08hr    2001 embryo 08-10hr    1972 embryo 10-12hr    1113 embryo 12-14hr    1278 embryo 14-16hr    1345 embryo 16-18hr    993 embryo 18-20hr    761 embryo 20-22hr    768 embryo 22-24hr    819 larva L1    781 larva L2    616 larva L3 12hr old    509 larva L3 puffstage 1-2    538 larva L3 puffstage 3-6    869 larva L3 puffstage 7-9    1027 white prepupae new    1138 white prepupae 12hr    901 white prepupae 24hr    1157 pupae 2d postWPP    855 pupae 3d postWPP    561 pupae 4d postWPP    494 adult male 01day    562 adult male 05day    645 adult male 30day    695 adult female 01day    1520 adult female 05day    2269 adult female 30day    2332 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3936) embryo 02-04hr  (3608) embryo 04-06hr  (2186) embryo 06-08hr  (2001) embryo 08-10hr  (1972) embryo 10-12hr  (1113) embryo 12-14hr  (1278) embryo 14-16hr  (1345) embryo 16-18hr  (993) embryo 18-20hr  (761) embryo 20-22hr  (768) embryo 22-24hr  (819) larva L1  (781) larva L2  (616) larva L3 12hr old  (509) larva L3 puffstage 1-2  (538) larva L3 puffstage 3-6  (869) larva L3 puffstage 7-9  (1027) white prepupae new  (1138) white prepupae 12hr  (901) white prepupae 24hr  (1157) pupae 2d postWPP  (855) pupae 3d postWPP  (561) pupae 4d postWPP  (494) adult male 01day  (562) adult male 05day  (645) adult male 30day  (695) adult female 01day  (1520) adult female 05day  (2269) adult female 30day  (2332) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3936) embryo 02-04hr  (3608) embryo 04-06hr  (2186) embryo 06-08hr  (2001) embryo 08-10hr  (1972) embryo 10-12hr    1113 embryo 12-14hr    1278 embryo 14-16hr    1345 embryo 16-18hr    993 embryo 18-20hr    761 embryo 20-22hr    768 embryo 22-24hr    819 larva L1    781 larva L2    616 larva L3 12hr old    509 larva L3 puffstage 1-2    538 larva L3 puffstage 3-6    869 larva L3 puffstage 7-9    1027 white prepupae new    1138 white prepupae 12hr    901 white prepupae 24hr    1157 pupae 2d postWPP    855 pupae 3d postWPP    561 pupae 4d postWPP    494 adult male 01day    562 adult male 05day    645 adult male 30day    695 adult female 01day  (1520) adult female 05day  (2269) adult female 30day  (2332) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3936 embryo 02-04hr    3608 embryo 04-06hr    2186 embryo 06-08hr    2001 embryo 08-10hr    1972 embryo 10-12hr    1113 embryo 12-14hr    1278 embryo 14-16hr    1345 embryo 16-18hr    993 embryo 18-20hr    761 embryo 20-22hr    768 embryo 22-24hr    819 larva L1    781 larva L2    616 larva L3 12hr old    509 larva L3 puffstage 1-2    538 larva L3 puffstage 3-6    869 larva L3 puffstage 7-9    1027 white prepupae new    1138 white prepupae 12hr    901 white prepupae 24hr    1157 pupae 2d postWPP    855 pupae 3d postWPP    561 pupae 4d postWPP    494 adult male 01day    562 adult male 05day    645 adult male 30day    695 adult female 01day    1520 adult female 05day    2269 adult female 30day    2332 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3936 embryo 02-04hr    3608 embryo 04-06hr    2186 embryo 06-08hr    2001 embryo 08-10hr    1972 embryo 10-12hr    1113 embryo 12-14hr    1278 embryo 14-16hr    1345 embryo 16-18hr    993 embryo 18-20hr    761 embryo 20-22hr    768 embryo 22-24hr    819 larva L1    781 larva L2    616 larva L3 12hr old    509 larva L3 puffstage 1-2    538 larva L3 puffstage 3-6    869 larva L3 puffstage 7-9    1027 white prepupae new    1138 white prepupae 12hr    901 white prepupae 24hr    1157 pupae 2d postWPP    855 pupae 3d postWPP    561 pupae 4d postWPP    494 adult male 01day    562 adult male 05day    645 adult male 30day    695 adult female 01day    1520 adult female 05day    2269 adult female 30day    2332 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0004864 expression level Developmental Stage   Expression Level embryo 00-02hr    3936 embryo 02-04hr    3608 embryo 04-06hr    2186 embryo 06-08hr    2001 embryo 08-10hr    1972 embryo 10-12hr    1113 embryo 12-14hr    1278 embryo 14-16hr    1345 embryo 16-18hr    993 embryo 18-20hr    761 embryo 20-22hr    768 embryo 22-24hr    819 larva L1    781 larva L2    616 larva L3 12hr old    509 larva L3 puffstage 1-2    538 larva L3 puffstage 3-6    869 larva L3 puffstage 7-9    1027 white prepupae new    1138 white prepupae 12hr    901 white prepupae 24hr    1157 pupae 2d postWPP    855 pupae 3d postWPP    561 pupae 4d postWPP    494 adult male 01day    562 adult male 05day    645 adult male 30day    695 adult female 01day    1520 adult female 05day    2269 adult female 30day    2332 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3936) embryo 02-04hr  (3608) embryo 04-06hr  (2186) embryo 06-08hr  (2001) embryo 08-10hr  (1972) embryo 10-12hr  (1113) embryo 12-14hr  (1278) embryo 14-16hr  (1345) embryo 16-18hr  (993) embryo 18-20hr  (761) embryo 20-22hr  (768) embryo 22-24hr  (819) larva L1  (781) larva L2  (616) larva L3 12hr old  (509) larva L3 puffstage 1-2  (538) larva L3 puffstage 3-6  (869) larva L3 puffstage 7-9  (1027) white prepupae new  (1138) white prepupae 12hr  (901) white prepupae 24hr  (1157) pupae 2d postWPP  (855) pupae 3d postWPP  (561) pupae 4d postWPP  (494) adult male 01day  (562) adult male 05day  (645) adult male 30day  (695) adult female 01day  (1520) adult female 05day  (2269) adult female 30day  (2332) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3936) embryo 02-04hr  (3608) embryo 04-06hr  2186 embryo 06-08hr  2001 embryo 08-10hr  1972 embryo 10-12hr    1113 embryo 12-14hr    1278 embryo 14-16hr    1345 embryo 16-18hr    993 embryo 18-20hr    761 embryo 20-22hr    768 embryo 22-24hr    819 larva L1    781 larva L2    616 larva L3 12hr old    509 larva L3 puffstage 1-2    538 larva L3 puffstage 3-6    869 larva L3 puffstage 7-9    1027 white prepupae new    1138 white prepupae 12hr    901 white prepupae 24hr    1157 pupae 2d postWPP    855 pupae 3d postWPP    561 pupae 4d postWPP    494 adult male 01day    562 adult male 05day    645 adult male 30day    695 adult female 01day  1520 adult female 05day  2269 adult female 30day  2332 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3936 embryo 02-04hr    3608 embryo 04-06hr    2186 embryo 06-08hr    2001 embryo 08-10hr    1972 embryo 10-12hr    1113 embryo 12-14hr    1278 embryo 14-16hr    1345 embryo 16-18hr    993 embryo 18-20hr    761 embryo 20-22hr    768 embryo 22-24hr    819 larva L1    781 larva L2    616 larva L3 12hr old    509 larva L3 puffstage 1-2    538 larva L3 puffstage 3-6    869 larva L3 puffstage 7-9    1027 white prepupae new    1138 white prepupae 12hr    901 white prepupae 24hr    1157 pupae 2d postWPP    855 pupae 3d postWPP    561 pupae 4d postWPP    494 adult male 01day    562 adult male 05day    645 adult male 30day    695 adult female 01day    1520 adult female 05day    2269 adult female 30day    2332 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3936 embryo 02-04hr    3608 embryo 04-06hr    2186 embryo 06-08hr    2001 embryo 08-10hr    1972 embryo 10-12hr    1113 embryo 12-14hr    1278 embryo 14-16hr    1345 embryo 16-18hr    993 embryo 18-20hr    761 embryo 20-22hr    768 embryo 22-24hr    819 larva L1    781 larva L2    616 larva L3 12hr old    509 larva L3 puffstage 1-2    538 larva L3 puffstage 3-6    869 larva L3 puffstage 7-9    1027 white prepupae new    1138 white prepupae 12hr    901 white prepupae 24hr    1157 pupae 2d postWPP    855 pupae 3d postWPP    561 pupae 4d postWPP    494 adult male 01day    562 adult male 05day    645 adult male 30day    695 adult female 01day    1520 adult female 05day    2269 adult female 30day    2332 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0004864    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0004864 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0004864 expression level Tissue   Expression Level Larval Central Nervous System    289.425 Larval Midgut    181.2 Larval Hindgut    218 Larval Malpighian Tubules    215 Larval Fat Body    195.6 Larval Salivary Gland    471.2 Larval Trachea    242.275 Larval Carcass    218.25 Adult Head    127.4 Adult Eye    157.75 Adult Brain    233.8 Adult Thoracic-Abdominal Ganglion    186 Adult Crop    191.6 Adult Midgut    190 Adult Hindgut    157.6 Adult Malpighian Tubules    193 Adult Fat Body    163.1 Adult Salivary Gland    307.4 Adult Heart    143.275 Adult VirginFemale Spermatheca    185.1 Adult InseminatedFemale Spermatheca    217.7 Adult Ovary    286.1 Adult Testis    28.7 Adult Male Accessory Gland    297.3 Adult Carcass    127.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    289.425 Larval Midgut    181.2 Larval Hindgut    218 Larval Malpighian Tubules    215 Larval Fat Body    195.6 Larval Salivary Gland    471.2 Larval Trachea    242.275 Larval Carcass    218.25 Adult Head    127.4 Adult Eye    157.75 Adult Brain    233.8 Adult Thoracic-Abdominal Ganglion    186 Adult Crop    191.6 Adult Midgut    190 Adult Hindgut    157.6 Adult Malpighian Tubules    193 Adult Fat Body    163.1 Adult Salivary Gland    307.4 Adult Heart    143.275 Adult VirginFemale Spermatheca    185.1 Adult InseminatedFemale Spermatheca    217.7 Adult Ovary    286.1 Adult Testis    28.7 Adult Male Accessory Gland    297.3 Adult Carcass    127.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    289.425 Larval Midgut    181.2 Larval Hindgut    218 Larval Malpighian Tubules    215 Larval Fat Body    195.6 Larval Salivary Gland    471.2 Larval Trachea    242.275 Larval Carcass    218.25 Adult Head    127.4 Adult Eye    157.75 Adult Brain    233.8 Adult Thoracic-Abdominal Ganglion    186 Adult Crop    191.6 Adult Midgut    190 Adult Hindgut    157.6 Adult Malpighian Tubules    193 Adult Fat Body    163.1 Adult Salivary Gland    307.4 Adult Heart    143.275 Adult VirginFemale Spermatheca    185.1 Adult InseminatedFemale Spermatheca    217.7 Adult Ovary    286.1 Adult Testis    28.7 Adult Male Accessory Gland    297.3 Adult Carcass    127.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    289.425 Larval Midgut    181.2 Larval Hindgut    218 Larval Malpighian Tubules    215 Larval Fat Body    195.6 Larval Salivary Gland    471.2 Larval Trachea    242.275 Larval Carcass    218.25 Adult Head    127.4 Adult Eye    157.75 Adult Brain    233.8 Adult Thoracic-Abdominal Ganglion    186 Adult Crop    191.6 Adult Midgut    190 Adult Hindgut    157.6 Adult Malpighian Tubules    193 Adult Fat Body    163.1 Adult Salivary Gland    307.4 Adult Heart    143.275 Adult VirginFemale Spermatheca    185.1 Adult InseminatedFemale Spermatheca    217.7 Adult Ovary    286.1 Adult Testis    28.7 Adult Male Accessory Gland    297.3 Adult Carcass    127.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0004864 expression level Tissue   Expression Level Larval Central Nervous System    289.425 Larval Midgut    181.2 Larval Hindgut    218 Larval Malpighian Tubules    215 Larval Fat Body    195.6 Larval Salivary Gland    471.2 Larval Trachea    242.275 Larval Carcass    218.25 Adult Head    127.4 Adult Eye    157.75 Adult Brain    233.8 Adult Thoracic-Abdominal Ganglion    186 Adult Crop    191.6 Adult Midgut    190 Adult Hindgut    157.6 Adult Malpighian Tubules    193 Adult Fat Body    163.1 Adult Salivary Gland    307.4 Adult Heart    143.275 Adult VirginFemale Spermatheca    185.1 Adult InseminatedFemale Spermatheca    217.7 Adult Ovary    286.1 Adult Testis    28.7 Adult Male Accessory Gland    297.3 Adult Carcass    127.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    289.425 Larval Midgut    181.2 Larval Hindgut    218 Larval Malpighian Tubules    215 Larval Fat Body    195.6 Larval Salivary Gland    471.2 Larval Trachea    242.275 Larval Carcass    218.25 Adult Head    127.4 Adult Eye    157.75 Adult Brain    233.8 Adult Thoracic-Abdominal Ganglion    186 Adult Crop    191.6 Adult Midgut    190 Adult Hindgut    157.6 Adult Malpighian Tubules    193 Adult Fat Body    163.1 Adult Salivary Gland    307.4 Adult Heart    143.275 Adult VirginFemale Spermatheca    185.1 Adult InseminatedFemale Spermatheca    217.7 Adult Ovary    286.1 Adult Testis    28.7 Adult Male Accessory Gland    297.3 Adult Carcass    127.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    289.425 Larval Midgut    181.2 Larval Hindgut    218 Larval Malpighian Tubules    215 Larval Fat Body    195.6 Larval Salivary Gland    471.2 Larval Trachea    242.275 Larval Carcass    218.25 Adult Head    127.4 Adult Eye    157.75 Adult Brain    233.8 Adult Thoracic-Abdominal Ganglion    186 Adult Crop    191.6 Adult Midgut    190 Adult Hindgut    157.6 Adult Malpighian Tubules    193 Adult Fat Body    163.1 Adult Salivary Gland    307.4 Adult Heart    143.275 Adult VirginFemale Spermatheca    185.1 Adult InseminatedFemale Spermatheca    217.7 Adult Ovary    286.1 Adult Testis    28.7 Adult Male Accessory Gland    297.3 Adult Carcass    127.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    289.425 Larval Midgut    181.2 Larval Hindgut    218 Larval Malpighian Tubules    215 Larval Fat Body    195.6 Larval Salivary Gland    471.2 Larval Trachea    242.275 Larval Carcass    218.25 Adult Head    127.4 Adult Eye    157.75 Adult Brain    233.8 Adult Thoracic-Abdominal Ganglion    186 Adult Crop    191.6 Adult Midgut    190 Adult Hindgut    157.6 Adult Malpighian Tubules    193 Adult Fat Body    163.1 Adult Salivary Gland    307.4 Adult Heart    143.275 Adult VirginFemale Spermatheca    185.1 Adult InseminatedFemale Spermatheca    217.7 Adult Ovary    286.1 Adult Testis    28.7 Adult Male Accessory Gland    297.3 Adult Carcass    127.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    127.4   NA  Eye    157.75   NA  Brain    233.8   289.425  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    186   NA  Crop    191.6   181.2  Midgut    190   218  Hindgut    157.6   215  Malpighian Tubules    193   195.6  Fat Body    163.1   471.2  Salivary Gland    307.4   NA  Heart    143.275   242.275  Trachea    NA   NA  VirginFemale Spermatheca    185.1   NA  InseminatedFemale Spermatheca    217.7   NA  Ovary    286.1   NA  Testis    28.7   NA  Male Accessory Gland    297.3   218.25  Carcass    127.8 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004864 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1594-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal hop1 hop18 hop19 hop20 hop21 hop22 hop23 hop24 lethal, with Scer\GAL4dpp.blk1 hopTum.Scer\UAS lethal, with Scer\GAL4en-e16E hopScer\UAS.cHa lethal, with Scer\GAL4hs.PB hopScer\UAS.cHa hopTum.Scer\UAS lethal (with hop25) hop29 hopM637 lethal (with hop29) hop25 lethal (with hopM637) hop25 lethal | dominant | heat sensitive hophs.PH hopTum.hs lethal | dominant | larval stage hop2 lethal | embryonic stage | germline clone | recessive | rescuable maternal effect hopX-82-36 hopX-139-3 hopX-170-25 lethal | embryonic stage | recessive | rescuable maternal effect hop2 hop25 lethal | germline clone | recessive | rescuable maternal effect hop12 lethal | heat sensitive hop1 hopTum lethal | larval stage hop20 hopTum.Act5C lethal | larval stage, with Scer\GAL4dome-PG125 hopTum.Scer\UAS lethal | larval stage | heat sensitive hopTum lethal | larval stage | maternal effect hop12 lethal | larval stage | recessive hop12 hopair lethal | maternal effect | polyphasic hop25 lethal | maternal effect | pupal stage hop12 lethal | partially hopTum lethal | partially (with hop25) hop32 hop33 lethal | partially (with hop32) hop25 lethal | partially (with hop33) hop25 lethal | partially | recessive hop25 lethal | polyphasic | recessive hopair lethal | recessive hop1 hop2 hop18 hop19 hop21 hop22 hop23 hop24 hopM637 hopr1 hopr2 hopr3 hopr4 hopr5 hopX-82-36 hopX-139-3 hopX-170-25 lethal | recessive | heat sensitive hopTum lethal | rescuable maternal effect hop1 hop2 hop3 hop4 hop9 hop13 hop14 hop15 hop16 hop27 hop29 hop32 hop33 hop34 hop35 lethal | semidominant hopTum semi-lethal (with Df(3L)ED4238) hopTum semi-lethal | dominant | heat sensitive hopTum semi-lethal | embryonic stage | maternal effect hop25 viable hopM637rev1 hopT-r7 viable, with Scer\GAL4pnr-MD237 hopGD9157 viable (with hop3) hop25 viable (with hop12) hop25 viable (with hop14) hop25 viable (with hop25) hop3 hop12 hop14 hop27 viable (with hop27) hop25 Sterility Allele female sterile hop25 fertile | female | reduced (with hop3) hop25 fertile | female | reduced (with hop25) hop3 male sterile hop25 hop26 Other Phenotypes Allele cell shape defective | extended germ band stage | germline clone hop2 hyperplasia hopTum hyperplasia | third instar larval stage hopTum immune response defective (with hop25) hop32 immune response defective (with hop32) hop25 immune response defective | heat sensitive hopTum increased cell number hopTum increased cell number | third instar larval stage hopTum melanotic mass phenotype hopTum melanotic mass phenotype, with Scer\GAL4Cg.PA hopTum.Scer\UAS melanotic mass phenotype, with Scer\GAL4Dot.PK hopScer\UAS.cHa hopTum.Scer\UAS melanotic mass phenotype | dominant hopTum melanotic mass phenotype | dominant | heat sensitive hopT42 hopTum melanotic mass phenotype | heat sensitive hopTum melanotic mass phenotype | larval stage hopTum melanotic mass phenotype | somatic clone, with Scer\GAL4Act5C.PI hopScer\UAS.cHa memory defective | adult stage, with Scer\GAL4c739 hopdsRNA.Scer\UAS.cCa memory defective | adult stage | heat sensitive, with Scer\GAL4ey-OK107, Scer\GAL80ts.αTub84B hopdsRNA.Scer\UAS.cCa memory defective | adult stage | RU486 conditional, with Scer\GAL4Mef2.247.Switch hopdsRNA.Scer\UAS.cCa neuroanatomy defective | larval stage hopTum.Scer\UAS planar polarity defective hop3 planar polarity defective | cell autonomous | somatic clone hop2 hop29 planar polarity defective | cell non-autonomous | recessive | somatic clone hop2 planar polarity defective | cell non-autonomous | somatic clone hop2 hop29 planar polarity defective | heat sensitive hop25 tumorigenic hopTum tumorigenic (with Df(3L)ED4238) hopTum visible hop3 hopTum visible, with Scer\GAL4dpp.blk1 hopScer\UAS.cHa visible, with Scer\GAL4elav.PLu hopScer\UAS.cHa hopTum.Scer\UAS visible, with Scer\GAL4en-e16E hopScer\UAS.cHa visible, with Scer\GAL4ey.PH hopScer\UAS.cHa hopTum.Scer\UAS visible, with Scer\GAL4ey.PU hopTum.Scer\UAS visible, with Scer\GAL4GMR.PF hopScer\UAS.cHa hopTum.Scer\UAS visible, with Scer\GAL4hs.PB hopScer\UAS.cHa hopTum.Scer\UAS visible (with hop25) hop32 visible (with hop32) hop25 visible | dominant hopTum visible | dominant | heat sensitive hophs.PH hopTum.hs hopTum visible | heat sensitive hop25 hopTum visible | recessive hopair wild-type hopT-r7.Act5C Phenotype manifest in Allele abdomen hopTum abdominal 4 ventral denticle belt hop2 abdominal 4 ventral denticle belt | germline clone | maternal effect hop2 hop25 abdominal 5 ventral denticle belt hop2 abdominal 5 ventral denticle belt | germline clone | maternal effect hop2 hop25 abdominal 6 ventral denticle belt hop2 abdominal 7 ventral denticle belt hop2 abdominal 7 ventral denticle belt | germline clone | maternal effect hop25 abdominal 8 ventral denticle belt hop2 axon hopTum axon, with Scer\GAL4hs.PB hopScer\UAS.cHa axoneme hop25 border follicle cell hop2 border follicle cell, with Scer\GAL4c306 hopTum.Scer\UAS border follicle cell, with Scer\GAL4slbo.2.6 hopScer\UAS.cHa border follicle cell (with hop2) hop25 border follicle cell (with hop25) hop2 border follicle cell | ectopic, with Scer\GAL4c306 hopScer\UAS.cHa hopTum.Scer\UAS border follicle cell | ectopic, with Scer\GAL4slbo.2.6 hopTum.Scer\UAS border follicle cell | ectopic | somatic clone, with Scer\GAL4Act5C.PP hopScer\UAS.cHa border follicle cell | somatic clone hop2 centripetally migrating follicle cell (with hop2) hop25 centripetally migrating follicle cell (with hop25) hop2 centripetally migrating follicle cell | somatic clone, with Scer\GAL4Act5C.PP hopScer\UAS.cHa crystal cell hopTum cyst progenitor cell hop25 denticle belt | germline clone | rescuable maternal effect hop2 dorsal trunk primordium | germline clone | maternal effect hop2 ectoderm | extended germ band stage | germline clone hop2 egg chamber (with hop3) hop25 egg chamber (with hop25) hop27 hop3 hop32 egg chamber (with hop27) hop25 egg chamber (with hop32) hop25 embryonic/larval anterior spiracle hopT42 embryonic/larval brain hopT42 embryonic/larval fat body hopT42 embryonic/larval foregut | embryonic stage hopT42 embryonic/larval hemocyte hopT42 hopTum embryonic/larval hemocyte | supernumerary hopTum embryonic/larval hemocyte | supernumerary, with Scer\GAL4stop.Hml hopTum.Scer\UAS embryonic/larval hindgut | embryonic stage hopT42 embryonic/larval lymph gland hopT42 hopTum embryonic/larval lymph gland | third instar larval stage hopTum embryonic/larval midgut | embryonic stage hopT42 embryonic/larval proventriculus hop2 embryonic abdominal segment 4 hop2 embryonic abdominal segment 4 | non-rescuable maternal effect hop2 embryonic abdominal segment 5 hop2 embryonic abdominal segment 5 | non-rescuable maternal effect hop2 embryonic abdominal segment | germline clone | maternal effect hopX-139-3 hopX-170-25 hopX-82-36 embryonic head hop2 embryonic hindgut, with Scer\GAL4byn-Gal4 hopTum.Scer\UAS embryonic hindgut | germline clone hop2 eye hop25 hop3 hop32 eye, with Scer\GAL4dpp.blk1 hopScer\UAS.cHa eye, with Scer\GAL4elav.PLu hopScer\UAS.cHa hopTum.Scer\UAS eye, with Scer\GAL4ey.PH hopScer\UAS.cHa hopTum.Scer\UAS eye, with Scer\GAL4ey.PU hopTum.Scer\UAS eye, with Scer\GAL4GMR.PF hopScer\UAS.cHa hopTum.Scer\UAS eye, with Scer\GAL4T13 hopScer\UAS.cHa eye | somatic clone hop2 hop29 eye equator | ectopic hop2 hop29 eye photoreceptor cell hop25 eye photoreceptor cell | somatic clone hop2 hop29 filzkorper | germline clone | maternal effect hopX-139-3 hopX-170-25 hopX-82-36 follicle cell | posterior (with hop2) hop25 follicle cell | posterior (with hop25) hop2 gastric caecum hopT42 gonad | maternal effect hop2 hemocyte hopTum hemocyte | precursor hopTum hemocyte | supernumerary hopTum hindgut hopTum hindgut, with Scer\GAL4hs.PB hopScer\UAS.cHa hindgut & nucleus hopTum hindgut & nucleus, with Scer\GAL4hs.PB hopScer\UAS.cHa interfollicle cell (with hop3) hop25 interfollicle cell (with hop25) hop3 hop32 hop33 interfollicle cell (with hop32) hop25 interfollicle cell (with hop33) hop25 interommatidial bristle hop25 hop3 hop32 lamellocyte hopTum lamellocyte, with Scer\GAL4He.PZ hopTum.Scer\UAS lamellocyte | ectopic hopTum lamellocyte | supernumerary hopTum lamellocyte | supernumerary, with Scer\GAL4Cg.PA hopTum.Scer\UAS lamellocyte | third instar larval stage hopTum larval outer optic anlage, with Scer\GAL4C855a hopTum.Scer\UAS male germline stem cell hop2 hop25 melanotic mass hopTum melanotic mass, with Scer\GAL4Cg.PA hopTum.Scer\UAS melanotic mass, with Scer\GAL4Dot.PK hopScer\UAS.cHa hopTum.Scer\UAS melanotic mass, with Scer\GAL4He.PZ hopTum.Scer\UAS melanotic mass | heat sensitive hopTum melanotic mass | somatic clone, with Scer\GAL4Act5C.PI hopScer\UAS.cHa mesothoracic ventral denticle belt hop2 nurse follicle cell (with hop2) hop25 nurse follicle cell (with hop25) hop2 nurse follicle cell | somatic clone hop2 ommatidium hop25 hop3 hop32 hopunspecified ommatidium | cell non-autonomous | somatic clone hop2 ommatidium | somatic clone hop2 hop29 oocyte associated follicle cell (with hop2) hop25 oocyte associated follicle cell (with hop25) hop2 ovary hopT-r7 peripheral nervous system hopTum peripheral nervous system, with Scer\GAL4hs.PB hopScer\UAS.cHa plasmatocyte hopTum plasmatocyte | supernumerary hopTum plasmatocyte | supernumerary, with Scer\GAL4Cg.PA hopTum.Scer\UAS podocyte hopTum polar follicle cell | supernumerary (with hop3) hop25 polar follicle cell | supernumerary (with hop25) hop27 hop3 hop33 polar follicle cell | supernumerary (with hop27) hop25 polar follicle cell | supernumerary (with hop33) hop25 pole cell | ectopic hopTum pole cell | maternal effect hop2 pole cell | supernumerary hopTum presumptive embryonic/larval tracheal system hop2 scutellum, with Scer\GAL4T59 hopScer\UAS.cHa scutum, with Scer\GAL4c754 hopScer\UAS.cHa segment | germline clone hop12 spermatogonium hop2 hop25 telson hop2 testis hop2 hop25 tracheal branch primordium | germline clone | maternal effect hop2 tracheal pit hopTum tracheal pit, with Scer\GAL4hs.PB hopScer\UAS.cHa wing, with Scer\GAL4T59 hopScer\UAS.cHa wing vein, with Scer\GAL4en-e16E hopScer\UAS.cHa wing vein, with Scer\GAL4T59 hopScer\UAS.cHa wing vein | ectopic (with hop25) hop32 wing vein | ectopic (with hop32) hop25
Classical Alleles ( 54 )
For All Classical Alleles Show
Allele of hop Class Mutagen Stocks Known lesion hop2 loss of function allele, amorphic allele - genetic evidence X ray 2 Yes hopTum neomorphic allele - genetic evidence, gain of function allele ethyl methanesulfonate 2 Yes hop27 amorphic allele - genetic evidence ethyl nitrosourea 1 Yes hop3 amorphic allele - genetic evidence X ray 1 Yes hop25 hypomorphic allele - genetic evidence ethyl methanesulfonate 1 Yes hopGG01333 1 -- hopKG01990 P-element activity 1 -- hop12 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes hop13 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes hop14 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes hop15 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- hop16 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- hop1 amorphic allele - genetic evidence X ray ethyl methanesulfonate 0 -- hop29 amorphic allele - genetic evidence ethyl nitrosourea 0 Yes hop32 amorphic allele - genetic evidence ethyl nitrosourea 0 Yes hop33 amorphic allele - genetic evidence ethyl nitrosourea 0 -- hop34 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes hop35 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- hop4 amorphic allele - genetic evidence X ray 0 Yes hop9 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes hop10 ethyl methanesulfonate 0 -- hop11 ethyl methanesulfonate 0 -- hop17 ethyl methanesulfonate 0 -- hop18 ethyl methanesulfonate 0 -- hop19 ethyl methanesulfonate 0 -- hop20 ethyl methanesulfonate 0 Yes hop21 ethyl methanesulfonate 0 -- hop22 ethyl methanesulfonate 0 -- hop23 ethyl methanesulfonate 0 -- hop24 ethyl methanesulfonate 0 -- hop26 ethyl methanesulfonate 0 -- hop28 ethyl nitrosourea 0 -- hop30 ethyl nitrosourea 0 -- hop31 ethyl nitrosourea 0 -- hop5 X ray 0 -- hop6 X ray 0 -- hop7 X ray 0 -- hop8 ethyl methanesulfonate 0 -- hopair loss of function allele P-element activity PM hybrid dysgenesis 0 -- hopF1.1 0 Yes hopJ1A.1 0 Yes hopM637 PM hybrid dysgenesis 0 Yes hopM637rev1 PM hybrid dysgenesis 0 -- hopr1 loss of function allele gamma ray 0 -- hopr2 loss of function allele gamma ray 0 -- hopr3 loss of function allele gamma ray 0 -- hopr4 loss of function allele gamma ray 0 -- hopr5 loss of function allele gamma ray 0 -- hopT-r7 ethyl methanesulfonate 0 -- hopT42 ethyl methanesulfonate 0 Yes hopunspecified 0 -- hopX-139-3 ethyl methanesulfonate 0 -- hopX-170-25 ethyl methanesulfonate 0 -- hopX-82-36 ethyl methanesulfonate 0 --
Alleles Carried on Transgenic Constructs ( 23 )
For All Alleles Carried on Transgenic Constructs Show
Allele of hop Class Mutagen Stocks Known lesion hopGD9157 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes hopGL00305 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes hopHMS00761 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes hopJF01267 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes hopJF01268 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes hopKK105136 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes hopAct5C.PH in vitro construct - minigene in vitro construct - regulatory fusion 0 Yes hopAct5C.PK in vitro construct - regulatory fusion 0 Yes hopAct5C.PY in vitro construct - regulatory fusion 0 Yes hopAct5C.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes hopdsRNA.Scer\UAS.cCa in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes hopdsRNA.Scer\UAS.cMa in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes hophs.PB in vitro construct - regulatory fusion 0 Yes hophs.PH in vitro construct - minigene in vitro construct - regulatory fusion 0 Yes hopMtnA.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes hopScer\UAS.cHa in vitro construct - minigene in vitro construct - regulatory fusion 0 Yes hopT-r7.Act5C in vitro construct - minigene in vitro construct - regulatory fusion 0 Yes hopT42.Act5C in vitro construct - regulatory fusion 0 Yes hopTum.Act5C in vitro construct - minigene in vitro construct - regulatory fusion 0 Yes hopTum.hs in vitro construct - minigene in vitro construct - regulatory fusion 0 Yes hopTum.Scer\UAS in vitro construct - minigene in vitro construct - regulatory fusion 0 Yes hopTumL.Act5C in vitro construct - regulatory fusion 0 Yes hopΔJH2.Act5C in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Duplicated in	Dp(1;2)v+65b (Geer et al., 1983, Eeken et al., 1985, Zhimulev et al., 1987, Watson et al., 1991, Hanratty and Dearolf, 1993) Dp(1;2)v+75d (Geer et al., 1983, Eeken et al., 1985, Hanratty and Dearolf, 1993) Dp(1;3)DC238 (Popodi et al., 2010-) Dp(1;3)v+74c (Eeken et al., 1985) Dp(1;Y)dsh+y+ (Zhimulev et al., 1987) Dp(1;Y)v+y+ (Geer et al., 1983, Zhimulev et al., 1987, Woods and Bryant, 1989, Watson et al., 1991, Hanratty and Dearolf, 1993) Dp(1;Y)v+y+366 (Zhimulev et al., 1987) Dp(1;Y)y+v+#3 (Eeken et al., 1985, Watson et al., 1991, Hanratty and Dearolf, 1993)
Not disrupted in	Df(1)59D3 (Zhimulev et al., 1987) Df(1)203C10 (Zhimulev et al., 1987) Df(1)DA622 (Woods and Bryant, 1989, Hanratty and Dearolf, 1993, Binari and Perrimon, 1994, Caggese et al., 1994) Df(1)HA85 (Hanratty and Dearolf, 1993) Df(1)HC133 (Zhimulev et al., 1987) Df(1)HF368 (Eeken et al., 1985) Df(1)m13 (Woods and Bryant, 1989, Hanratty and Dearolf, 1993, Caggese et al., 1994) Df(1)m259-4 (Eeken et al., 1985, Hanratty and Dearolf, 1993) Df(1)N71 (Eeken et al., 1985) Df(1)ras-P14 (Zhimulev et al., 1987) Df(1)ras-v17 (Zhimulev et al., 1987, Hanratty and Dearolf, 1993) Df(1)ras-v-P26 (Zhimulev et al., 1987) Df(1)sbr1 (Zhimulev et al., 1987) Df(1)sbr8 (Zhimulev et al., 1987) Df(1)sbr9 (Zhimulev et al., 1987) Df(1)sbr10 (Zhimulev et al., 1987) Df(1)v64f (Zhimulev et al., 1987, Hanratty and Dearolf, 1993) Df(1)v-B151 (Zhimulev et al., 1987) Df(1)v-L1 (Geer et al., 1983, Zhimulev et al., 1987) Df(1)v-L2 (Geer et al., 1983, Zhimulev et al., 1987, Hanratty and Dearolf, 1993) Df(1)v-L3 (Geer et al., 1983, Eeken et al., 1985, Zhimulev et al., 1987, Hanratty and Dearolf, 1993) Df(1)v-L4 (Geer et al., 1983, Eeken et al., 1985, Zhimulev et al., 1987) Df(1)v-L7 (Zhimulev et al., 1987) Df(1)v-L11 (Zhimulev et al., 1987) Df(1)v-L15 (Eeken et al., 1985, Zhimulev et al., 1987, Hanratty and Dearolf, 1993) Df(1)v-M1 (Zhimulev et al., 1987) Df(1)v-M5 (Zhimulev et al., 1987) Df(1)v-M6 (Zhimulev et al., 1987) Df(1)v-M7 (Zhimulev et al., 1987) Df(1)v-P5 (Zhimulev et al., 1987) Df(1)v-P16 (Zhimulev et al., 1987) Df(1)v-P22 (Zhimulev et al., 1987)
Not duplicated in	Dp(1;2)r+75c (Watson et al., 1991) Dp(1;2)v+63i (Geer et al., 1983, Eeken et al., 1985, Zhimulev et al., 1987, Watson et al., 1991, Hanratty and Dearolf, 1993) Dp(1;3)f+71b (Watson et al., 1991) Dp(1;Y)v+y+U15 (Zhimulev et al., 1987)
Disrupted in	Df(1)GA112 (Hanratty and Dearolf, 1993) Df(1)KA7 (Zhimulev et al., 1987, Hanratty and Dearolf, 1993) Df(1)N71 (Zhimulev et al., 1987, Woods and Bryant, 1989, Hanratty and Dearolf, 1993, Binari and Perrimon, 1994, Caggese et al., 1994, Harbecke and Lengyel, 1995) Df(1)RA37 (Zhimulev et al., 1987, Woods and Bryant, 1989, Hanratty and Dearolf, 1993, Caggese et al., 1994)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9157} NA P{KK105136} NA P{TRiP.GL00305} NA P{TRiP.HMS00761} NA P{TRiP.JF01267} NA P{TRiP.JF01268} NA P{UAS-hop.dsRNA.M} NA P{UAS-hop.H} NA P{UAS-hop.RNAi} NA P{UAS-hop.Tum} NA heat-shock construct P{hs-hop} NA P{hsp-hop} NA P{hs-Tum} NA characterization construct P{Act/T-r7} NA P{Act/Tum-l} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{}hopair NA P{}hopM637 NA P{SUPor-P}hopKG01990 NA insertion of mobile activating element P{Mae-UAS.6.11}hopGG01333 NA
Gene Ontology: Function, Process & Cellular Component ( 51 unique terms )
Terms Based on Experimental Evidence ( 28 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
apical constriction inferred from mutant phenotype (Bertet et al., 2009) blastoderm segmentation inferred from mutant phenotype (Chen et al., 2003) border follicle cell migration inferred from mutant phenotype (Xi et al., 2003) cell proliferation inferred from mutant phenotype (Binari and Perrimon, 1994) compound eye development inferred from mutant phenotype (Luo et al., 1999, Luo and Dearolf, 2001) compound eye morphogenesis inferred from mutant phenotype (Tsai and Sun, 2004) compound eye photoreceptor cell differentiation inferred from mutant phenotype (Luo et al., 1999) defense response to virus inferred from mutant phenotype (Dostert et al., 2005) equator specification inferred from mutant phenotype (Luo et al., 1999, Luo and Dearolf, 2001) establishment of ommatidial planar polarity inferred from mutant phenotype (Luo et al., 1999) eye-antennal disc morphogenesis inferred from mutant phenotype (Ekas et al., 2006) hemocyte differentiation inferred from mutant phenotype (Luo et al., 2002) hindgut morphogenesis inferred from mutant phenotype (Johansen et al., 2003, Li et al., 2003) JAK-STAT cascade inferred from genetic interaction with Stat92E AND inferred from sequence or structural similarity (Hou et al., 1996) larval lymph gland hemopoiesis inferred from mutant phenotype (Sorrentino et al., 2007) long-term memory inferred from mutant phenotype (Copf et al., 2011) mediolateral intercalation inferred from mutant phenotype (Bertet et al., 2009) nervous system development inferred from mutant phenotype (Li et al., 2003) ommatidial rotation inferred from mutant phenotype (Luo and Dearolf, 2001) open tracheal system development inferred from mutant phenotype (Chen et al., 2003, Li et al., 2003) ovarian follicle cell development inferred from mutant phenotype (Xi et al., 2003) ovarian follicle cell stalk formation inferred from mutant phenotype (Assa-Kunik et al., 2007) periodic partitioning inferred from mutant phenotype (Binari and Perrimon, 1994) primary sex determination inferred from mutant phenotype (Jinks et al., 2000) regulation of embryonic cell shape inferred from mutant phenotype (Bertet et al., 2009) regulation of hemocyte differentiation inferred from mutant phenotype (Zettervall et al., 2004) regulation of JAK-STAT cascade inferred from mutant phenotype (Kallio et al., 2010) stem cell maintenance inferred from mutant phenotype (Kiger et al., 2001)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 26 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441 (FlyBase Curators et al., 2004-) non-membrane spanning protein tyrosine kinase activity non-traceable author statement (Swiss-Prot Project Members, 1997.2.1) protein tyrosine kinase activity inferred from sequence or structural similarity with human JAK1 (Binari and Perrimon, 1994) inferred from sequence or structural similarity with mouse Jak2 (FlyBase, 1992-) non-traceable author statement (Oates, 1997.11.10, Morrison et al., 2000, Luo and Dearolf, 2001) traceable author statement (Castelli-Gair Hombria and Brown, 2002, Agaisse and Perrimon, 2004)
Biological Process
CV term Evidence References
blastoderm segmentation traceable author statement (Hanratty and Dearolf, 1993, Luo and Dearolf, 2001) border follicle cell migration traceable author statement (Castelli-Gair Hombria and Brown, 2002) cellular defense response non-traceable author statement (Agaisse and Perrimon, 2004) cytokinesis traceable author statement (Hanratty and Dearolf, 1993) defense response non-traceable author statement (Lemaitre, 2000.12.20) encapsulation of foreign target non-traceable author statement (Agaisse and Perrimon, 2004) germ-line stem cell division traceable author statement (Lin, 2002) hemocyte proliferation traceable author statement (Agaisse and Perrimon, 2004) hemopoiesis traceable author statement (Meister et al., 2000, Luo and Dearolf, 2001, Evans et al., 2003) humoral immune response traceable author statement (Agaisse and Perrimon, 2004) imaginal disc-derived leg morphogenesis non-traceable author statement (Luo and Dearolf, 2001) imaginal disc-derived wing morphogenesis non-traceable author statement (Luo and Dearolf, 2001) immune response traceable author statement (Kimbrell and Beutler, 2001) JAK-STAT cascade non-traceable author statement (Lemaitre, 2000.12.20) traceable author statement (Castelli-Gair Hombria and Brown, 2002, Jinks et al., 2000, Agaisse and Perrimon, 2004) lamellocyte differentiation traceable author statement (Agaisse and Perrimon, 2004) oogenesis traceable author statement (Castelli-Gair Hombria and Brown, 2002) protein phosphorylation inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR001245, InterPro:IPR008266, InterPro:IPR020635 (FlyBase Curators et al., 2004-) non-traceable author statement (Morrison et al., 2000, Swiss-Prot Project Members, 1997.2.1) sex determination non-traceable author statement (Luo and Dearolf, 2001) somatic stem cell division traceable author statement (Lin, 2002) STAT protein import into nucleus traceable author statement (Agaisse and Perrimon, 2004) tyrosine phosphorylation of STAT protein traceable author statement (Luo and Dearolf, 2001, Agaisse and Perrimon, 2004)
Cellular Component
CV term Evidence References
cytoplasm non-traceable author statement (Swiss-Prot Project Members, 1997.2.1) traceable author statement (Hou and Perrimon, 1997) cytoskeleton inferred from electronic annotation with InterPro:IPR000299 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions hop allele Gene References hop2 Cdk4 (Chen et al., 2003) CycE (Chen et al., 2003) os (Chen et al., 2002, Bach et al., 2003) hop12 os (Harrison et al., 1998) hop14 os (Harrison et al., 1998) hop25 Cdk4 (Chen et al., 2003) os (Harrison et al., 1998, Kiger et al., 2001, McGregor et al., 2002) hop27 os (Harrison et al., 1998, McGregor et al., 2002) hopair CycE (Brumby et al., 2004) hopScer\UAS.cHa os (Bach et al., 2003) hopT42 Stat92E (Luo et al., 1997) hopTum awd (Zinyk et al., 1993) brm (Remillieux-Leschelle et al., 2002) BRWD3 (Muller et al., 2005) Cdk4 (Chen et al., 2003) CycE (Chen et al., 2003) dome (Chen et al., 2002) Dsor1 (Luo et al., 2002) E(bx) (Badenhorst et al., 2002) E(hopTum) (Zinyk et al., 1993) ecd (Sorrentino et al., 2002) phl (Luo et al., 2002) Ptp61F (Muller et al., 2005) Stat92E (Hou et al., 1996, Yan et al., 1996, Yan et al., 1996, Luo et al., 1997, Remillieux-Leschelle et al., 2002, Muller et al., 2005) Su(var)2-10 (Betz et al., 2001) hopunspecified dome (Brown et al., 2001) Stat92E (Zeidler et al., 1999) unspecified os (Harrison et al., 1998) Rac1 (Silver, 2005) Socs36E (Callus and Mathey-Prevot, 2002) Stat92E (Silver and Montell, 2001)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58492 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0004864 DroID - A comprehensive database of gene and protein interactions. • FBgn0004864 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32080
Orthologs
Genome-wide drosophilid orthologs	Dana\GF21804 Dere\GG18859 Dgri\GH12542 Dmoj\GI14899 Dper\GL14993 Dpse\GA14036 Dsim\hop Dvir\GJ15330 Dwil\GK25609 Dyak\GE17301
Curated drosophilid orthologs	Dpse\GA14036   Dsim\hop
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AGAP008354-PA Anopheles gambiae (mosquito) XP_001121783.1 Apis mellifera (honey bee) XP_001948047.1 Acyrthosiphon pisum (pea aphid) 90761 Branchiostoma floridae (lancelet) BGIBMGA004082-PA Bombyx mori (silk worm) ENSBTAP00000015986 Bos taurus (bovine) ENSCAFP00000003097 Canis familiaris (dog) ENSCINP00000010889 Ciona intestinalis (sea squirt) ENSCPOP00000013203 Cavia porcellus (guinea pig) 299747 Daphnia pulex (daphnia) ENSDARP00000049468 Danio rerio (zebra fish) ENSECAP00000008048 Equus caballus (horse) ENSGACP00000018113 Gymnopilus aculeatus (mushroom) ENSGALP00000037587 Gallus gallus (chicken) ENSP00000371067 Homo sapiens (human) ISCW016158-PA Ixodes scapularis (deer tick) ENSMODP00000019196 Monodelphis domestica (gray opossum) ENSMMUP00000019119 Macaca mulatta (rhesus monkey) ENSMUSP00000025705 Mus musculus (house mouse) XP_001602854.1 Nasonia vitripennis (wasp) ENSOANP00000015999 Ornithorynchus anatinus (platypus) ENSORLP00000001864 Oryzias latipes (japanese killifish) LOC_Os04g52140.1 Oryza sativa (asian rice) PHUM005044-PA Pediculus humanus (human body louse) ENSPPYP00000021551 Pongo pygmaeus (orangutan) ENSPTRP00000035490 Pan troglodytes (chimpanzee) ENSRNOP00000021218 Rattus norvegicus (norway rat) XP_974422.2 Tribolium castaneum (red flour beetle) ENSTNIP00000007608 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000009730 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000001294 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11610 NV16630 LH23786 ISCW016158 FBgn0234774 FBgn0227759 FBgn0227568 FBgn0202524 FBgn0068592 FBgn0166189 FBgn0166188 JGI_V11_299747 FBgn0074067 FBgn0152597 FBgn0137650 FBgn0120021 FBgn0111066 FBgn0098804 CPIJ001760 BGIBMGA004082 ACYPI008118 GB16422 AGAP008354 HOP PHUM202560 GLEAN_08648
Stocks & Reagents
Stocks Listed in FlyBase ( 15 )
Bloomington	6032 hop2/FM7a 8493 y1 hop27/FM7c 8494 y1 hop25/Basc 15097 y1 P{SUPor-P}hopKG01990 8495 y1 w* hop3/Basc 8492 y1 v1 hopTum/FM7c 31319 y1 v1; P{TRiP.JF01268}attP2 31699 y1 v1; P{TRiP.JF01267}attP2 35386 y1 sc* v1; P{TRiP.GL00305}attP2
Kyoto	108563 hop2/FM7a
VDRC	v102830 P{KK105136}VIE-260B v40037 w1118; P{GD9157}v40037/CyO
	More stocks available...
Genomic Clones ( 2 )
	BACR07P15 BACR28L07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 29 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	HL03036 RH47993
Other clones	DPiM_RH47993
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT17492 LD34422 RE05551 RH13495
Other clones	16348 43585 50358 53025 55058 172618 214437.5 CK01.49B.H3 CK01.110B.E8 Dmel_dig_015836_0607_0446 EC051512 EC051534 EC054991 EK041430 EK088304 EK127441 EK162919 EK272564 EK301503 EP10548 RH09358 RP003199276
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004864 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32080
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: hop CG1594 (Zhong, 1999.11)
Source for database merge of
Additional comments	Identified by PCR fragment; relationship to other protein tyrosine kinase genes not known. (Oates, 1997.11.10)
Other Comments
	hop is required for os-induced Stat92E phosphorylation. (Baeg et al., 2005) Treatment of S2-derived S2-NP cells with dsRNA made from templates generated with primers directed against hop results in a 12-24-fold decrease in JAK/STAT activity. (Baeg et al., 2005) When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of G1 phase cells is seen. (Bettencourt-Dias et al., 2004) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Stat92E is part of an intracellular Jak-Stat signalling pathway and is activated by the hop Jak kinase. Partial loss of hop gene product activity gives a phenotype similar to that of Stat92E mutants, supporting the idea that the Jak-Stat pathway is involved in regulation of oogenesis. (Baksa et al., 2002) phl acts downstream of hop during differentiation of lamellocytes in larvae. (Luo et al., 2002) hop is required for the renewal of male germline stem cells and for maintenance of the somatic cyst progenitor cell population in the testis. (Kiger et al., 2001) hop is required for cell proliferation/survival in the eye imaginal disc, for the differentiation of photoreceptor cells, and for the establishment of the equator and of ommatidial polarity. (Luo et al., 1999) Candidate gene for testicular atrophy quantitative trait locus. (Macdonald and Goldstein, 1999) Dominant hop mutations cause hop to be a hyperactive kinase that can cause hyperactivation of the hop Stat92E pathway. (Luo et al., 1997) Phylogenetic analysis of the PTK family. (Suga et al., 1997) The hop kinase acts upstream of Stat92E in the JAK/STAT pathway. hop may activate Stat92E to regulate transcription of target genes such as eve. Stat92E is epistatic to hop. (Hou et al., 1996) A mutation in Stat92E has been identified by suppression of a hop mutant phenotype. (Yan et al., 1996) An allele of Stat92E was identified in a screen for second site suppressors of hopTum. (Yan et al., 1996) Mutations in Jak kinase, hop, can cause leukaemia-like abnormalities. (Luo et al., 1995) hop is an example of a maternally provided nonreceptor tyrosine kinase involved in segmentation of embryos. hop has a zygotic role in cellular proliferation. (Binari and Perrimon, 1994) Mutants display neoplastic phenotype. (Mechler, 1994) hop is required for cell division and proper embryonic segmentation. (Hanratty and Dearolf, 1993) Identification: Identified by PCR fragment; relationship to other protein tyrosine kinase genes not known. (Lindsley and Zimm, 1992) Most of the mutants are homozygous late zygotic (L-P) lethals; one mutant is a larval lethal; two other mutants have some adult survivors (hemizygous males being morphologically normal, but 40% of the homozygous females and 85% of the hemizygous females showing major defects). Heteroallelic females are lethal with the exceptions noted under the alleles. There is a maternal effect on thoracic and abdominal segments, the most extreme embryos <up>produced from homozygous "l(1)hop" germ-line clones that have not received a paternal copy of hop+</up> showing defects in the posterior spiracles and in segments T2 (denticle belt deleted). T3, A4 and A5 (segment missing) and A8 (segment reduced in size); the least extreme mutant embryos from germ-line clones show defects in segment A5. Defects visible in early segmentation stages. The extent of the defects is dependent on the strength of the maternal alleles and the paternal contribution. Wild-type sperm can rescue all defects, except those in A5. A few of the rescued progeny hatch and develop into adults. (Lindsley and Zimm, 1992) The wild-type allele of hop is required for the continued cell division of all diploid cells as well as the establishment of the normal array of segments. (Lindsley and Zimm, 1992) hop is dosage compensated. All viable heteroallelic combinations are female sterile, failing to produce eggs or laying abnormal eggs that are small, with a clear chorion and with chorionic filaments absent or partially fused. (Perrimon and Mahowald, 1986)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078564 RefSeq (Proteins) • NP_511119 DDBJ / EMBL / GenBank • AA697717 AAA62441 AAF48035 AAL48491 AAP20030 AJ002915 AJ569571 AJ569572 AJ569573 AJ569574 AJ569575 AJ569576 AJ569577 AJ569579 AJ569580 AJ569581 AJ569582 AJ569583 AJ569584 AJ569585 AJ569586 AJ569587 AJ569588 AJ569590 AJ569591 AJ569592 AJ569593 AJ569594 AJ569595 AW941430 AY070869 BI617608 BT006331 BZ665584 CAA05750 L26975 Entrez Gene - A searchable database of RefSeq genes. • 32080 UniProtKB/Swiss-Prot • Q24592
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • FERM domain (IPR000299) Protein kinase, catalytic domain (IPR000719) SH2 motif (IPR000980) Tyrosine-protein kinase, active site (IPR008266) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Band 4.1 domain (IPR019749) Tyrosine-protein kinase, catalytic domain (IPR020635) Serine-threonine/tyrosine-protein kinase (IPR001245)
Linkouts
	BioGRID - A database of protein and genetic interactions • 58492 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0004864 DroID - A comprehensive database of gene and protein interactions. • FBgn0004864 DRSC - Results from RNAi screens. • FBgn0004864 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004864 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1594-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004864 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 93495 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32080 InParanoid A subset of ortholog calls from InParanoid. • AGAP008354-PA Anopheles gambiae (mosquito) XP_001121783.1 Apis mellifera (honey bee) XP_001948047.1 Acyrthosiphon pisum (pea aphid) 90761 Branchiostoma floridae (lancelet) BGIBMGA004082-PA Bombyx mori (silk worm) ENSBTAP00000015986 Bos taurus (bovine) ENSCAFP00000003097 Canis familiaris (dog) ENSCINP00000010889 Ciona intestinalis (sea squirt) ENSCPOP00000013203 Cavia porcellus (guinea pig) 299747 Daphnia pulex (daphnia) ENSDARP00000049468 Danio rerio (zebra fish) ENSECAP00000008048 Equus caballus (horse) ENSGACP00000018113 Gymnopilus aculeatus (mushroom) ENSGALP00000037587 Gallus gallus (chicken) ENSP00000371067 Homo sapiens (human) ISCW016158-PA Ixodes scapularis (deer tick) ENSMODP00000019196 Monodelphis domestica (gray opossum) ENSMMUP00000019119 Macaca mulatta (rhesus monkey) ENSMUSP00000025705 Mus musculus (house mouse) XP_001602854.1 Nasonia vitripennis (wasp) ENSOANP00000015999 Ornithorynchus anatinus (platypus) ENSORLP00000001864 Oryzias latipes (japanese killifish) LOC_Os04g52140.1 Oryza sativa (asian rice) PHUM005044-PA Pediculus humanus (human body louse) ENSPPYP00000021551 Pongo pygmaeus (orangutan) ENSPTRP00000035490 Pan troglodytes (chimpanzee) ENSRNOP00000021218 Rattus norvegicus (norway rat) XP_974422.2 Tribolium castaneum (red flour beetle) ENSTNIP00000007608 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000009730 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000001294 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /gene/hopscotc.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32080 modMine - Data generated by the modENCODE project. • FBgn0004864 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11610 NV16630 LH23786 ISCW016158 FBgn0234774 FBgn0227759 FBgn0227568 FBgn0202524 FBgn0068592 FBgn0166189 FBgn0166188 JGI_V11_299747 FBgn0074067 FBgn0152597 FBgn0137650 FBgn0120021 FBgn0111066 FBgn0098804 CPIJ001760 BGIBMGA004082 ACYPI008118 GB16422 AGAP008354 HOP PHUM202560 GLEAN_08648
Synonyms & Secondary IDs ( 29 )
Reported As
Symbol Synonym	4 (Lefevre and Watkins, 1986, Lefevre, 1981) CG1594 (Morrison et al., 2000, Keleman et al., 2009.8.5, Wertheim et al., 2005, Ni et al., 2008, Ni et al., 2010.12.1, Ni et al., 2011.7.19) d-jak (Callus and Mathey-Prevot, 2002) DmHD-160 (Oates, 1997.11.10, Oates et al., 1998, ) Dm JAK (Gibson and Spring, 1998) HD-160   Hop (Waterhouse et al., 2007, Farkas et al., 2007, Hoffmann and Reichhart, 1997, Muller et al., 2005, Richter et al., 2011, Rodrigues and Bach, 2007, Han and Harrison, 2007, Yasugi et al., 2007, Keller, 2006, Karsten et al., 2006, Jang et al., 2009, Rivas et al., 2008, Bina et al., 2010) hop (Rehwinkel et al., 2006, Ekas et al., 2006, Minakhina and Steward, 2006, Jang and Montell, 2007, Shen and Tanda, 2007, Yasugi et al., 2007, Guo and Harrison, 2007, Hombria et al., 2005, Tsai and Sun, 2004, Brun et al., 2006, Krzemien et al., 2007, Gao et al., 2009, Kleino et al., 2008, Copf et al., 2011, Bach et al., 2007, Munier et al., 2002, Tokusumi et al., 2009, Yan et al., 2011, Han and Harrison, 2008, Copf and Preat, 2008, Baeg et al., 2007, Assa-Kunik et al., 2007, Yamashita et al., 2005, Xing et al., 2007, Ayala-Camargo et al., 2007, Wawersik et al., 2005, Starz-Gaiano et al., 2008, López-Onieva et al., 2008, Yasugi et al., 2008, Sorrentino et al., 2007, Tsai et al., 2007, Avila and Erickson, 2007, Kwon et al., 2008, Shi et al., 2008, Sotillos et al., 2008, Rawlings et al., 2004, Almudi et al., 2009, Buchon et al., 2009, Xie et al., 2005, Habayeb et al., 2009, Kwon et al., 2009, Buchon et al., 2009, Flaherty et al., 2009, Tokusumi et al., 2009, Jiang et al., 2009, Zeitlinger et al., 2007, Shi et al., 2006, Rehwinkel et al., 2005, Bertet et al., 2009, Oishi et al., 2006, Hill-Burns and Clark, 2009, Sinenko and Mathey-Prevot, 2004, Obbard et al., 2009, Popodi et al., 2010-, Gutierrez-Aviño et al., 2009, Beebe et al., 2010, Sotillos et al., 2010, Wertheim et al., 2005, Lin et al., 2010, Leatherman and DiNardo, 2008, Jacques et al., 2009, Ekas et al., 2010, Reddy et al., 2010, Kallio et al., 2010, Beltran et al., 2007, Mukherjee et al., 2005, Novakova and Dolezal, 2011, Jiang et al., 2011, Pastor-Pareja et al., 2008, Liu et al., 2010, Wright et al., 2011, Vidal et al., 2010, Makki et al., 2010) HOP (Arbouzova and Zeidler, 2006) Hop1 (Oates et al., 1998) hopscotch (Brown et al., 2006) JAK (Ip, 2005, Ohlstein et al., 2004, Sheng et al., 2005, Brown et al., 2005, Seyedoleslami Esfahani et al., 2003, Mukherjee and Zeidler, 2003, Meister, 2004, Terry et al., 2004, Solnica-Krezel and Eaton, 2003, Lopez-Schier, 2003, Lavine and Strand, 2002, Mushegian and Medzhitov, 2001, Feix et al., 2003, Xi et al., 2003, Castelli-Gair Hombria and Brown, 2002, Harrison et al., 2002, Silver and Montell, 2002, Kisseleva et al., 2002, Rawlings and Harrison, 2002, Harrison et al., 2002, Wasserman and DiNardo, 2001, Morrison et al., 2000, Zeidler and Perrimon, 2000, Morrison et al., 2000, Lagueux et al., 2000, Perrimon and Stern, 1999, Zeidler et al., 1999, Blair, 1999, Mathey-Prevot et al., 1998, Zeidler and Perrimon, 1998, Sheng et al., 2006, Sexton et al., 2006, Guo and Harrison, 2006, DEVERGNE and NOSELLI, 2006, Ayala et al., 2007, Nystul and Spradling, 2006, Starz-Gaiano and Montell, 2004, Castelli-Gair Hombria, 2006, Sotillos and Castelli-Gair, 2007, KrzemieÅ„ et al., 2007, Kronhamn et al., 2007, Eleftherianos et al., 2007, Kimble and Page, 2007, Yan et al., 2011, Sexton and Harrison, 2008, Issigonis et al., 2008, Wrobel et al., 2008, Wawersik et al., 2008, Han and Harrison, 2008, Yasugi et al., 2008, Copf and Preat, 2008, McConnell et al., 2008, Assa-Kunik et al., 2007, Ayala and Bach, 2008, Bakal et al., 2008, Shi et al., 2008, Gutierrez-Aviño et al., 2009) Jak (Beachy et al., 2004, Rorth, 2002, Kockel et al., 2001, Bruckner et al., 2003, Barolo and Posakony, 2004, Peifer and McEwen, 2002, Luo and Dearolf, 1997, Bach and Perrimon, 2002, Matunis and Tulina, 2001, Lee et al., 2008, Jiang et al., 2011) jak (Bertet et al., 2009) L4 (Eeken et al., 1985) l(1)10Be (Caggese et al., 1994, ) l(1)G18   l(1)hop (Binnari and Perrimon, 1990, Perrimon and Mahowald, 1986, ) l(1)L4 (Zhimulev et al., 1987) msvl   Tum (Mechler, 1990, Gateff and Mechler, 1989, ) Tum-1 (Kisseleva et al., 2002)
Name Synonym	hopscotch (Starz-Gaiano and Montell, 2004, Gao et al., 2009, Kleino et al., 2008, Bach et al., 2007, Tanda et al., 2008, Yamashita et al., 2005, Avila and Erickson, 2007, Bertet et al., 2009, Hill-Burns and Clark, 2009, Beebe et al., 2010, Ekas et al., 2010, Kallio et al., 2010, Paddibhatla et al., 2010, Mukherjee et al., 2005) Hopscotch (Yasugi et al., 2007, Ayala et al., 2007, Arbouzova and Zeidler, 2006, Montell, 2006, Ekas et al., 2008, Kim et al., 2007, Sorrentino et al., 2007, Sotillos et al., 2008, Classen et al., 2009, Bina et al., 2010) Hopskotch (Zhao and Garbers, 2002, Payne and Braun, 2006) JAK kinase (Shi et al., 2007) Janus-family kinase (Nystul and Spradling, 2006) Janus kinase (Gutierrez-Aviño et al., 2009) locus 18 (Dybas et al., 1983) Tumorous
Secondary FlyBase IDs
	FBgn0001211 FBgn0003895 FBgn0022799
References ( 376 )
Generate a list of	All references relating to this gene ( 376 )
List References by type	Research paper  ( 169 ) Supplementary material  ( 8 ) Review  ( 66 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 111 ) FlyBase analysis  ( 2 ) Conference report  ( 1 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 2 ) Book  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 2 ) Automatic genome annotation  ( 1 )
Recent research papers ( 21 )
	Booker et al., 2011, BMC Genomics 12: 50 False negative rates in Drosophila cell-based RNAi screens: a case study. [FBrf0212969] Copf et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(19): 8059--8064 Cytokine signaling through the JAK/STAT pathway is required for long-term memory in Drosophila. [FBrf0213703] Jiang et al., 2011, Cell Stem Cell 8(1): 84--95 EGFR/Ras/MAPK Signaling Mediates Adult Midgut Epithelial Homeostasis and Regeneration in Drosophila. [FBrf0212694] Minakhina et al., 2011, Dev. Biol. 352(2): 308--316 JAK/STAT and the GATA factor Pannier control hemocyte maturation and differentiation in Drosophila. [FBrf0213300] Novakova and Dolezal, 2011, PLoS ONE 6(3): e17741 Expression of Drosophila Adenosine Deaminase in Immune Cells during Inflammatory Response. [FBrf0213278] Richter et al., 2011, Nat. Cell Biol. 13(9): 1029--1039 The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements. [FBrf0215050] Wright et al., 2011, Cell. Signal. 23(5): 920--927 Differential activities of the Drosophila JAK/STAT pathway ligands Upd, Upd2 and Upd3. [FBrf0213113] Xu et al., 2011, Dev. Biol. 354(1): 31--43 EGFR, Wingless and JAK/STAT signaling cooperatively maintain Drosophila intestinal stem cells. [FBrf0213634] Yan et al., 2011, FASEB J. 25(1): 232--241 Unphosphorylated STAT and heterochromatin protect genome stability. [FBrf0212715] Beebe et al., 2010, Dev. Biol. 338(1): 28--37 JAK/STAT signaling coordinates stem cell proliferation and multilineage differentiation in the Drosophila intestinal stem cell lineage. [FBrf0209772] Bina et al., 2010, EMBO Rep. 11(3): 201--207 Transcriptional targets of Drosophila JAK/STAT pathway signalling as effectors of haematopoietic tumour formation. [FBrf0210131] Ekas et al., 2010, Dev. Biol. 344(2): 621--636 Characterization of a dominant-active STAT that promotes tumorigenesis in Drosophila. [FBrf0211400] Kallio et al., 2010, FASEB J. 24(11): 4467--4479 Eye transformer is a negative regulator of Drosophila JAK/STAT signaling. [FBrf0212202] Karpowicz et al., 2010, Development 137(24): 4135--4145 The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration. [FBrf0212383] Lin et al., 2010, J. Mol. Cell. Biol. 2(1): 37--49 Paracrine Unpaired Signaling through the JAK/STAT Pathway Controls Self-renewal and Lineage Differentiation of Drosophila Intestinal Stem Cells. [FBrf0209721] Liu et al., 2010, J. Cell. Biochem. 109(5): 992--999 JAK-STAT is restrained by Notch to control cell proliferation of the Drosophila intestinal stem cells. [FBrf0210433] Makki et al., 2010, PLoS Biol. 8(8): e1000441 A short receptor downregulates Jak/STAT signalling to control the Drosophila cellular immune response. [FBrf0211466] Paddibhatla et al., 2010, PLoS Pathog. 6(12): e1001234 Role for sumoylation in systemic inflammation and immune homeostasis in Drosophila larvae. [FBrf0212643] Reddy et al., 2010, Development 137(14): 2397--2408 Influence of fat-hippo and notch signaling on the proliferation and differentiation of Drosophila optic neuroepithelia. [FBrf0211109] Sotillos et al., 2010, Dev. Biol. 340(2): 571--582 An efficient approach to isolate STAT regulated enhancers uncovers STAT92E fundamental role in Drosophila tracheal development. [FBrf0210508] Vidal et al., 2010, J. Cell Sci. 123(20): 3457--3466 Negative regulation of Drosophila JAK-STAT signalling by endocytic trafficking. [FBrf0211993] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...